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Abacavir sulfate

Name: Abacavir sulfate
Brand: Selleck Chemicals
SKU: S3165
Rating: 5 (6 reviews)

Synonyms: 1592U89

Catalog No.S3165 Purity: 99.85%

Abacavir (1592U89) is a commonly used nucleoside analogue with potent antiviral activity against HIV-1.

Abacavir sulfate Chemical Structure

CAS: 188062-50-2

Selleck's Abacavir sulfate has been cited by 6 publications

Purity & Quality Control

Batch: Purity: 99.85%

99.85

Abacavir sulfate Related Products

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Signaling Pathway

Reverse Transcriptase Signaling Pathway

Choose Selective Reverse Transcriptase Inhibitors

Biological Activity

Description

Abacavir (1592U89) is a commonly used nucleoside analogue with potent antiviral activity against HIV-1.

Targets

HIV-1 reverse-transcriptase ^[1]

In vitro
In vitro	Abacavir is an analog of guanosine (a purine). Its target is the viral reverse transcriptase enzyme.

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2024-01-11)
NCT04133012	Completed	HIV-1 Infection	ANRS Emerging Infectious Diseases\|ViiV Healthcare	February 10 2020	Not Applicable
NCT02708342	Completed	HIV	Ospedale San Raffaele\|Merck Sharp & Dohme LLC	April 2016	--

References

Chemical Information & Solubility

Molecular Weight	335.35	Formula	C₁₄H₁₈N₆O.1/2 H₂SO₄
CAS No.	188062-50-2	SDF	Download Abacavir sulfate SDF
Smiles	C1CC1NC2=C3C(=NC(=N2)N)N(C=N3)C4CC(C=C4)CO.C1CC1NC2=C3C(=NC(=N2)N)N(C=N3)C4CC(C=C4)CO.OS(=O)(=O)O
Storage (From the date of receipt)	3 years-20°Cpowder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years-20°Cpowder		1 month-20°Cin solvent

In vitro
Batch:

Water : 67 mg/mL

DMSO : Insoluble ( Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : Insoluble

Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.

In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

Dilution Calculator Molecular Weight Calculator

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg Average weight of animals: g Dosing volume per animal:μL Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO + % + % Tween 80 + % ddH₂O

%DMSO+ %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3
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