Zidovudine

Catalog No.S2579 Synonyms: Azidothymidine, NSC 602670

Zidovudine  Chemical Structure

Molecular Weight(MW): 267.24

Zidovudine (ZDV) is a nucleoside analogue reverse transcriptase inhibitor, used to treat HIV.

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Biological Activity

Description Zidovudine (ZDV) is a nucleoside analogue reverse transcriptase inhibitor, used to treat HIV.
Targets
Reverse transcriptase [1]
In vitro

Zidovudine pretreatment has potent anti-HIV-1 activity in the newly infected T and monocytic cells but not in chronically infected cells. [1] Inhibition of reverse transcription by Zidovudine decreases p24 antigen levels modestly, decreased HIV-1 gag by 19-fold, and inhibits detection of 2-LTR HIV-1 DNA. [2] Zidovudine and dideoxynucleosides deplete wild-type mitochondrial DNA levels and increase deletedmitochondrial DNA levels in cultured Kearns-Sayre syndrome fibroblasts. [3] Zidovudine (AZT, 0.1-50 mM) has a concentration dependent suppressive effect on the growth of granulocyte-monocyte colony forming unit (CFU-GM) derived colonies. Zidovudine exposure also induces a concentration dependent suppressive effect (35-90%) on GM-CSF receptor type alpha (GM-CSFR alpha) gene expression. Zidovudine causes a much lower decrease (15-22%) on the IL-3 receptor type alpha (IL-3R alpha) message level, and has an insignificant effect on glyceraldehyde 3-phosphate dehydrogenase (GAPDH) and c-myc message levels. [4] Zidovudine causes a concentration-dependent inhibition in the levels of the mRNA of Epo receptors and c-fos, whereas the level of c-myc mRNA is unaffected. Zidovudine also inhibits protein kinase C (PKC) activity in a concentration- and time-dependent manner, causing 50% inhibition at 10 mM within 3 hours. Zidovudine-induced down-regulation of Epo receptors and c-fos expression coupled with inhibition of Epo receptor-mediated signal transduction through PKC are significant contributory factors to AZT-induced erythroid toxicity. [5]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
human C8166 cells MW\GeY5kfGmxbjDhd5NigQ>? Mly0RY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTJVu[W5iaX3teY5w\GWoaXPp[Y5kgSC4aYL1d{AyKGmwZnXjeIVlKGmwIHj1cYFvKEN6MU[2JINmdGy|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZidnnyeZMucW6mdXPl[EBkgXSxcHH0bIlkKGWoZnXjeEwhTUN3ME20[U0xPiEQvF2= MVqyNVU{PDV2MB?=
PBMC M1LqfGZ2dmO2aX;uJIF{e2G7 NY\wWllzOSEQvF2= M4LY[mFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGhKXjFiVFXLTUBz\XCuaXPheIlwdiCrbjDQRm1EKGG2IEGgeW0tKEmFNUC9NE4xODBzNDFOwG0> NE[1bHAyPjR{MECyOy=>
human H9 cells MU\GeY5kfGmxbjDhd5NigQ>? MoW5OkBl[Xm| MV;BcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDIeY1idiCrbX31co9l\W[rY3nlcoN6KH[rcoXzJFEhO0JiaX7m[YN1\WRiaX6gbJVu[W5iSEmgZ4VtdHNiaX7m[YN1\WRid3n0bEA3NjJ3IIXMJI9nKH[rcoXzJJN1d2OtIHHzd4V{e2WmIHHzJIV5eHKnc4Ppc44hd2ZicEK0JIFvfGmpZX6gZYZ1\XJiNjDkZZl{KHCxc4TpcoZm[3Srb36gZpkhTUyLU1GsJGlEPTB;MD6zJI5O NY\SboxuOjByOE[xOFk>
AA5 cells NEXpb3ZHfW6ldHnvckBie3OjeR?= MUPBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDv[kBJfW2jbjDpcY12dm:mZX\pZ4lmdmO7II\pdpV{KDFiM1KgbY5n\WO2ZXSgbY4hSUF3IHPlcIx{KGmwZnXjeIVlKHerdHigNU42PiC3TDDv[kB3cXK3czDzeI9kcyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKH[rcnHsJHJmfmW{c3WgeJJidnOlcnnweIF{\SCkeTDbN2heXFSSIHnuZ49zeG:{YYTpc44h[XO|YYmsJGlEPTB;MD6zJI5O NXP0R4JpOjByOE[xOFk>
CEM cells MoHoSpVv[3Srb36gZZN{[Xl? MWHDc45k\W62cnH0bY9vKG:oIITo[UBlenWpIILld5VtfGmwZzDpckA2OCVicnXkeYN1cW:wIH;mJJRp\SC4aYLhcEBkgXSxcHH0bIlkKGWoZnXjeEBi\2GrboP0JGhKXi1zIILldIxq[2G2aX;uJIlvKEOHTTDj[YxteyxiRVO1NF0xNjN{IH7N MVSyNVU{OjB4
MT4 cells MXLGeY5kfGmxbjDhd5NigQ>? NUfZR4dTPCCmYYnz M{[1Z2FvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGhKXjFiM1KgZZN{\XO|ZXSgZZMhcW6qaXLpeIlwdiCxZjD2bZJ2ey2rbnT1Z4VlKGO7dH;wZZRpd2enbnnjbZR6KGmwIF3UOEBk\WyuczDh[pRmeiB2IHThfZMh[nliTWTUJIF{e2G7LDDFR|UxRTBwNzDuUS=> MkTWNVc6PjR5OU[=
human MT2 cells MUXGeY5kfGmxbjDhd5NigQ>? NWDVbXgyOSCq NGjMV4tCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJUVZzIIP1ZpR6eGViQj2zRkBqdm[nY4Tl[EBqdiBzIHjyMZBz\XS{ZXH0[YQhcHWvYX6gUXQzKGOnbHzzJIF{e2W|c3XkJIF{KGmwaHnibZRqd25ib3[gcZVtfGmleXPs[UBz\XCuaXPheIlwdiCvZXHzeZJm\CCxbjDkZZkhPSCyb4P0bY5n\WO2aX;uJIJ6KFKWIGPQRUwhTUN3ME2xMlIhdk1? NVHCPJNbOTh|MU[1NlE>
C8166 cells M{XqbmZ2dmO2aX;uJIF{e2G7 NHmxbHFKdmirYnn0bY9vKG:oIFjJWlEuO0JicnXwcIlk[XSrb36gbY4hSzhzNk[gZ4VtdHNuIFXDOVA:OS57IH7N MoHaNVYzPzl5N{O=
CEM-SS cell MVvGeY5kfGmxbjDhd5NigQ>? M{TjNmlvcGmkaYTvdpkh[WO2aY\peJkh[WejaX7zeEB1cGViSFnWMVEucW6mdXPl[EBkgXSxcHH0bIlkKGWoZnXjeEBqdiCFRV2tV3Mh[2WubDDsbY5mNCCLQ{WwQVAvODB{IN88US=> M1K2cFc3PTB4N{i=
PBLs M4TORWZ2dmO2aX;uJIF{e2G7 NGXvUGNCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEB{fWK2eYDlJIl{d2yjdHWgS{B{fHKjaX6gbY4hWEKOczCodIVzcXCqZYLhcEBjdG:xZDDsfY1xcG:leYTld{ktKEmFNUC9NE4xODJizszN NVq5e2ZQOTF5MEi5NVM>
human lymphocyte CEM/0 cell line MYTGeY5kfGmxbjDhd5NigQ>? NVXIfJlzSW62aTDITXYuOSCjY4Tpeol1gSCrbjDoeY1idiCueX3wbI9kgXSnIFPFUU8xKGOnbHygcIlv\SxiRVO1NF0xNjByMzFOwG0> M4n3Nlg1Pzh7MES=
Jurkat cell NWr6R4RxTnWwY4Tpc44h[XO|YYm= NEK0VFVKdmirYnn0c5J6KGOxbnPlcpRz[XSrb36gZYdicW6|dDDITXYuOSCrbn\lZ5Rm\CCMdYLrZZQh[2WubDDsbY5meyxiSVO1NF0xNjBzIN88US=> NXfiO4xWPzh|N{KyNC=>
human H9 cells NImzbJNEgXSxdH;4bYNqfHliYYPzZZk> NH35VIc3KGSjeYO= NVTEfodXS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUDliY3XscJMh[W[2ZYKgOkBl[Xm|IHL5JG1VXCCjc4PhfUwhTUN3ME2wMlAyKM7:TR?= MVmyNFg1Pjh4OB?=
C3H/3T3 cells MoHtSpVv[3Srb36gZZN{[Xl? NE[1dXhEd26lZX70doF1cW:wIH;mJINwdXCxdX7kJJJmeXWrcnXkJJRwKGmwaHnibZQhUEmYLUGgbY5lfWOnZDDjfZRweGG2aH;n[Y5q[2m2eTDv[kBOW1ZvaX7keYNm\CC2cnHud4Zwem2jdHnvckBw\iCFM1ivN3Q{KGOnbHzzJIJ6KDVyJTygSWM2OD1yLkCyJO69VQ>? NGPMcZEzODF4N{G4
U937 cells NF3neJZHfW6ldHnvckBie3OjeR?= MWfF[oZm[3SrdnWgZ49v[2WwdILheIlwdiC{ZYH1bZJm\CCob4KgZY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgUYFkem:yaHHn[UBk\WyuIHzpcoUhd2ZiVUmzO{Bk\WyuczDv[kBJfW2jbjDifUBZXFRiYYPzZZktKEWFNUC9NE4xOyEQvF2= M3TWcFc6OzJ3Mk[=

... Click to View More Cell Line Experimental Data

Protocol

Solubility (25°C)

In vitro DMSO 53 mg/mL (198.32 mM)
Water 53 mg/mL warmed (198.32 mM)
Ethanol 18 mg/mL warmed (67.35 mM)

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 267.24
Formula

C10H13N5O4

CAS No. 30516-87-1
Storage powder
Synonyms Azidothymidine, NSC 602670

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
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Molecular Weight Calculator

Molecular Weight Calculator

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Total Molecular Weight: g/mol

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Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT01441063 Recruiting Castleman Disease|Castlemans Disease|Giant Lymph Node Hyperplasia National Cancer Institute (NCI)|National Institutes of Health Clinical Center (CC) August 6, 2011 Phase 2
NCT00001644 Completed HIV Infection National Institute of Allergy and Infectious Diseases (NIAID)|National Institutes of Health Clinical Center (CC) March 3, 1997 Phase 1
NCT02437110 Enrolling by invitation Amyotrophic Lateral Sclerosis National Institute of Neurological Disorders and Stroke (NINDS)|National Institutes of Health Clinical Center (CC) April 23, 2015 Phase 1
NCT02737046 Recruiting Adult T-cell Leukemia-Lymphoma|ATLL University of Miami November 2016 Phase 2
NCT02832778 Recruiting HIV St Stephens Aids Trust|Mylan Inc.|United States Agency for International Development (USAID) September 2016 Phase 1
NCT02712801 Recruiting HIV/AIDS and Infections National Center for Women and Childrens Health, China CDC|National Center for AIDS/STD Control and Prevention, China CDC|Maternal and Child Health Hospital of Yunan Province|Maternal and Child Health Hospital of Sichuan Province|Maternal and Child Health Hospital of Guangxi Province|Maternal and Child Health Hospital of Xinjiang Uygur Autonomous Region|Guangdong Provincial Maternal and Child Health Hospital April 2016 Phase 4

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

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Frequently Asked Questions

  • Question 1:

    Do you happen to have any information regarding the half-life of AZT?

  • Answer:

    The Half-life of S2579 in human is available (http://www.rxlist.com/retrovir-drug/clinical-pharmacology.htm), about 0.5-3 hours in adult subjects.

Reverse Transcriptase Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID