Tenofovir
Catalog No.S1401 Synonyms: GS-1278
Molecular Weight(MW): 287.21
Tenofovir blocks reverse transcriptase and hepatitis B virus infections.
Purity & Quality Control
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Biological Activity
| Description | Tenofovir blocks reverse transcriptase and hepatitis B virus infections. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| Features | Tenofovir disoproxil fumarate is the prodrug form of tenofovir. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Targets |
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| In vitro |
Tenofovir reduces the viral cytopathic effect of HIV-1(IIIB), HIV-2(ROD) and HIV(EHO) with EC50 of 1.15 μg/mL, 1.12 μg/mL and 1.05 μg/mL in MT-4 cells. Tenofovir also reduces the viral cytopathic effect of SIV(mac251) , SIV(B670) ,SHIV(89.6) and SHIV(RTSHIV). [1] Tenofovir is uniquely active against multinucleoside-resistant HIV expressing the Q151M mutation, but shows reduced susceptibility to the T69S insertion mutations. [2] Tenofovir inhibits hepatitis B virus (HBV) activity in HepG2 2.2.15, HepAD38 and HepAD79 cells. [3] Tenofovir (4 μM) completely inhibits the growth of HIVIIIB in MT-2 cells. Tenofovir inhibits synthesis of negative strand strong-stop DNA with IC50 of 9 µM for wild-type RT, 6 µM for M184V RT and 50 µM for K65R RT. [4] |
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| Cell Data |
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| In vivo | Tenofovir (30 mg/kg) completely prevents SIV infection in all macaques without toxicity. Tenofovir treatment reduces plasma viral RNA levels to undetectable, with parallel decreases in the infectivity of plasma and infectious cells in peripheral blood mononuclear cells and cerebrospinal fluid (CSF) and stabilization of CD4+ T-cell numbers. Tenofovir (30 mg/kg, s.c.) completely abrogates HIV infection via intravaginal exposure in pig-tailed macaques. [5] |
Protocol
| Animal Research:[1] |
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Solubility (25°C)
| In vitro | DMSO | 4 mg/mL warmed (13.92 mM) |
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| Water | 2 mg/mL (6.96 mM) | |
| Ethanol | Insoluble | |
| In vivo | Add solvents individually and in order: 30% propylene glycol, 5% Tween 80, 65% D5W |
30 mg/mL |
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Chemical Information
| Molecular Weight | 287.21 |
|---|---|
| Formula | C9H14N5O4P |
| CAS No. | 147127-20-6 |
| Storage | powder |
| in solvent | |
| Synonyms | GS-1278 |
Bio Calculators
Molarity Calculator
Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)
*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).
Dilution Calculator
Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )
* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).
Molecular Weight Calculator
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Definitions of molecular mass, molecular weight, molar mass and molar weight:
Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.
Molarity Calculator
Clinical Trial Information
| NCT Number | Recruitment | Conditions | Sponsor/Collaborators | Start Date | Phases |
|---|---|---|---|---|---|
| NCT03032536 | Recruiting | Hepatitis B|Chronic Hepatitis B|Viral Hepatitis B | Alios Biopharma Inc. | January 31, 2017 | Phase 1 |
| NCT03048422 | Not yet recruiting | HIV Infections | National Institute of Allergy and Infectious Diseases (NIAID) | April 30, 2017 | Phase 3 |
| NCT00524173 | Recruiting | Hepatitis B | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)|National Institutes of Health Clinical Center (CC) | August 29, 2007 | Phase 2 |
| NCT03043326 | Recruiting | HIV Prevention | Asociación Civil Impacta Salud y Educación, Peru|Gilead Sciences | January 23, 2017 | -- |
| NCT02454764 | Not yet recruiting | HBV | Institute of Liver and Biliary Sciences, India | May 2017 | -- |
| NCT02937779 | Not yet recruiting | Hepatitis B Chronic Infection|Pregnancy | French National Institute for Health and Medical Research-French National Agency for Research on AIDS and Viral Hepatitis (Inserm-ANRS) | April 2017 | Phase 4 |
Tech Support
Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.
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