Tenofovir Alafenamide (GS-7340)
Catalog No.S7856

Molecular Weight(MW): 476.47
Tenofovir Alafenamide (GS-7340) is a prodrug of tenofovir, which is a reverse transcriptase inhibitor, used to treat HIV and Hepatitis B.
Purity & Quality Control
Choose Selective Reverse Transcriptase Inhibitors
Biological Activity
Description | Tenofovir Alafenamide (GS-7340) is a prodrug of tenofovir, which is a reverse transcriptase inhibitor, used to treat HIV and Hepatitis B. | ||||||||||||||||
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Targets |
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In vitro |
GS-7340 has a potent anti-HIV activity with IC50 of 0.005 μM. [1] GS 7340 has a half-life of 90 min in human plasma and a half-life of 28.3 min in an MT-2 cell extract at 37°C. [2] the hepatic uptake of GS-7340 isfacilitated by OATP1B1 and OATP1B3, respectively. GS-7340 inhibits HBV reverse transcriptase after being converted to the pharmacologically active form, TFV-DP. [3] |
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Cell Data |
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In vivo | In male beagle dogs, GS 7340 (10 mg/kg, p.o.) results in an enhanced distribution to lymphatic tissue. [2] |
Protocol
Solubility (25°C)
In vitro | DMSO | 95 mg/mL (199.38 mM) |
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Ethanol | 95 mg/mL (199.38 mM) | |
Water | Insoluble |
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Chemical Information
Molecular Weight | 476.47 |
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Formula | C21H29N6O5P |
CAS No. | 379270-37-8 |
Storage | powder |
Synonyms | N/A |
Bio Calculators
Molarity Calculator
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Molarity Calculator
Clinical Trial Information
NCT Number | Recruitment | Conditions | Sponsor/Collaborators | Start Date | Phases |
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NCT03048422 | Not yet recruiting | HIV Infections | National Institute of Allergy and Infectious Diseases (NIAID) | April 30, 2017 | Phase 3 |
NCT02957994 | Not yet recruiting | Hepatitis B | Asian Pacific Liver Center at St. Vincent Medical Center | February 2017 | Phase 4 |
NCT02984852 | Recruiting | Healthy | Janssen Scientific Affairs, LLC | December 2016 | Phase 1 |
NCT02962739 | Not yet recruiting | Healthy Volunteers | University of Colorado, Denver | December 2016 | Phase 1 |
NCT02957864 | Recruiting | Renal Insufficiency,Chronic|Hiv|Therapeutic Agent Toxicity | Erasmus Medical Center|Gilead Sciences | October 2016 | Phase 4 |
NCT02904369 | Recruiting | HIV | CONRAD|United States Agency for International Development (USAID)|Agility Clinical, Inc. | October 2016 | Phase 1 |
Tech Support
Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.
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