Tenofovir Alafenamide (GS-7340)

Catalog No.S7856

Tenofovir Alafenamide (GS-7340) Chemical Structure

Molecular Weight(MW): 476.47

Tenofovir Alafenamide (GS-7340) is a prodrug of tenofovir, which is a reverse transcriptase inhibitor, used to treat HIV and Hepatitis B.

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Biological Activity

Description Tenofovir Alafenamide (GS-7340) is a prodrug of tenofovir, which is a reverse transcriptase inhibitor, used to treat HIV and Hepatitis B.
Targets
Reverse transcriptase [1]
In vitro

GS-7340 has a potent anti-HIV activity with IC50 of 0.005 μM. [1] GS 7340 has a half-life of 90 min in human plasma and a half-life of 28.3 min in an MT-2 cell extract at 37°C. [2] the hepatic uptake of GS-7340 isfacilitated by OATP1B1 and OATP1B3, respectively. GS-7340 inhibits HBV reverse transcriptase after being converted to the pharmacologically active form, TFV-DP. [3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
MT2 cells Ml7MR5l1d3SxeHnjbZR6KGG|c3H5 M3XVeGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG1VOiClZXzsd{whS0N3ME20NEDPxE1? NGH3OWszPDZ6NkCxNi=>

... Click to View More Cell Line Experimental Data

In vivo In male beagle dogs, GS 7340 (10 mg/kg, p.o.) results in an enhanced distribution to lymphatic tissue. [2]

Protocol

Solubility (25°C)

In vitro DMSO 95 mg/mL (199.38 mM)
Ethanol 95 mg/mL (199.38 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 476.47
Formula

C21H29N6O5P

CAS No. 379270-37-8
Storage powder
in solvent
Synonyms N/A

Bio Calculators

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02904369 Completed HIV CONRAD|United States Agency for International Development (USAID)|Agility Clinical Inc. October 6 2016 Phase 1
NCT02431247 Active not recruiting Immunodeficiency Virus Type 1 Human Janssen Sciences Ireland UC July 6 2015 Phase 3
NCT03241641 Recruiting Chronic Hepatitis b Young-Suk Lim|Samsung Medical Center|Korea University Guro Hospital|Konkuk University Medical Center|Seoul National University Hospital|Asan Medical Center October 26 2017 Phase 4
NCT03646370 Recruiting HIV-1-infection|Metabolic Syndrome|Cardiovascular Diseases|Weight Gain|Renal Function Abnormal|Hyperglycemia Thomas Jefferson University July 25 2018 --
NCT03604016 Not yet recruiting Hepatitis B IlDong Pharmaceutical Co Ltd September 23 2018 Phase 4
NCT03115736 Recruiting HIV and Hepatitis B Coinfection University Hospital Inselspital Berne May 23 2017 Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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Reverse Transcriptase Signaling Pathway Map

Related Reverse Transcriptase Products

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID