Tenofovir Alafenamide (GS-7340)
Catalog No.S7856
Molecular Weight(MW): 476.47
Tenofovir Alafenamide (GS-7340) is a prodrug of tenofovir, which is a reverse transcriptase inhibitor, used to treat HIV and Hepatitis B.
Purity & Quality Control
Choose Selective Reverse Transcriptase Inhibitors
Biological Activity
| Description | Tenofovir Alafenamide (GS-7340) is a prodrug of tenofovir, which is a reverse transcriptase inhibitor, used to treat HIV and Hepatitis B. | ||||||||||||||||
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| Targets |
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| In vitro |
GS-7340 has a potent anti-HIV activity with IC50 of 0.005 μM. [1] GS 7340 has a half-life of 90 min in human plasma and a half-life of 28.3 min in an MT-2 cell extract at 37°C. [2] the hepatic uptake of GS-7340 isfacilitated by OATP1B1 and OATP1B3, respectively. GS-7340 inhibits HBV reverse transcriptase after being converted to the pharmacologically active form, TFV-DP. [3] |
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| Cell Data |
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| In vivo | In male beagle dogs, GS 7340 (10 mg/kg, p.o.) results in an enhanced distribution to lymphatic tissue. [2] |
Protocol
Solubility (25°C)
| In vitro | DMSO | 95 mg/mL (199.38 mM) |
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| Ethanol | 95 mg/mL (199.38 mM) | |
| Water | Insoluble |
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Chemical Information
| Molecular Weight | 476.47 |
|---|---|
| Formula | C21H29N6O5P |
| CAS No. | 379270-37-8 |
| Storage | powder |
| in solvent | |
| Synonyms | N/A |
Bio Calculators
Molarity Calculator
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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).
Dilution Calculator
Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )
* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).
Molecular Weight Calculator
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Definitions of molecular mass, molecular weight, molar mass and molar weight:
Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.
Molarity Calculator
Clinical Trial Information
| NCT Number | Recruitment | Conditions | Sponsor/Collaborators | Start Date | Phases |
|---|---|---|---|---|---|
| NCT02904369 | Completed | HIV | CONRAD|United States Agency for International Development (USAID)|Agility Clinical Inc. | October 6 2016 | Phase 1 |
| NCT02431247 | Active not recruiting | Immunodeficiency Virus Type 1 Human | Janssen Sciences Ireland UC | July 6 2015 | Phase 3 |
| NCT03241641 | Recruiting | Chronic Hepatitis b | Young-Suk Lim|Samsung Medical Center|Korea University Guro Hospital|Konkuk University Medical Center|Seoul National University Hospital|Asan Medical Center | October 26 2017 | Phase 4 |
| NCT03646370 | Recruiting | HIV-1-infection|Metabolic Syndrome|Cardiovascular Diseases|Weight Gain|Renal Function Abnormal|Hyperglycemia | Thomas Jefferson University | July 25 2018 | -- |
| NCT03604016 | Not yet recruiting | Hepatitis B | IlDong Pharmaceutical Co Ltd | September 23 2018 | Phase 4 |
| NCT03115736 | Recruiting | HIV and Hepatitis B Coinfection | University Hospital Inselspital Berne | May 23 2017 | Phase 2 |
Tech Support
Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.
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