Catalog No.S1704

Emtricitabine  Chemical Structure

Molecular Weight(MW): 247.25

Emtricitabine (FTC) is a new nucleoside agent that has activity against both human immunodeficiency virus (HIV) and hepatitis B virus. It is a reverse transcriptase inhibitor. Intracellular half-life is 39 h.

Size Price Stock Quantity  
In DMSO USD 160 In stock
USD 120 In stock
USD 370 In stock
USD 747 In stock
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Biological Activity

Description Emtricitabine (FTC) is a new nucleoside agent that has activity against both human immunodeficiency virus (HIV) and hepatitis B virus. It is a reverse transcriptase inhibitor. Intracellular half-life is 39 h.
Reverse transcriptase [1]
In vitro

Emtricitabine moderately reduces hepatocyte proliferation independent of effects on mtDNA in HepG2 human hepatoma cells. Emtricitabine plus tenofovir slightly reduced cell proliferation without affecting mitochondrial parameters. [1] Emtricitabine efficiently converts to their active metabolites in PBMCs and CEM cells. Emtricitabine combined with Tenofovir displays additive to synergistic activity against HIV replication in PBMCs and results in strongly synergistic anti-HIV activity in MT-2 cells against both wild-type and mutant virus. [2] Emtricitabine demonstrates antiviral activity against laboratory adapted strains of HIV-1 and HIV-2 in various cell system. Emtricitabine also exhibits antiviral activity in cell culture against feline and simian immuno-deficiency viruses (SIVs). Emtricitabine consistently exhibits up to 10-fold greater activity than lamivudine against all viruses tested in all T-cell lines. Emtricitabine generally demonstrates greater potency in vitro in human PBMCs than in MT-4 lines. [3] Emtricitabine also exhibits anti-HBV activity in vitro (EC50, 0.01–0.04 µM) that is comparable to the anti-HBV activity of 3TC. [4] Emtricitabine is approximately fourfold more active than 3TC in assays in the transformed T-cell line MT-4 infected with HIV-(1IIIB), whereas Zidovudine is more active than Emtricitabine. Emtricitabine, Lamivudine and Zidovudine are equally active against a panel of eight primary HIV-1 isolates from antiretroviral-naive subjects in PBMCs. [5]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
HepAD38 cell NU[wc|JmTnWwY4Tpc44h[XO|YYm= Mn2yTY5pcWKrdHnvckBw\iCqZYDheIl1cXNiQjD2bZJ2eyC{ZYDsbYNifGmxbjDpckB1cGViSHXwRWQ{QCClZXzsJIxqdmVuIFXEOVA:OC5yMzFOwG0> MVixNVEzQDZ3Mh?=
MT2 cells Ml3oSpVv[3Srb36gZZN{[Xl? NFvrZ5JCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJUVZzIHnu[oVkfGWmIHnuJIh2dWGwIF3UNkBk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oII\pdoFtKHKncHzpZ4F1cW:wLDDJR|UxRTBwMES0JO69VQ>? MWixPVU6Pjh6NR?=
HeLa P4/R5 cells MmHsSpVv[3Srb36gZZN{[Xl? NXjjeYsxSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUEmYMTDpcoZm[3SnZDDpckBpfW2jbjDI[WxiKFB2L2K1JINmdGy|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZidnnyZYwhemWybHnjZZRqd25uIFnDOVA:OC5zNzFOwG0> NEXCb2IyQTV7Nki4OS=>
HepG2 cells NXi0Rod1S3m2b4TvfIlkcXS7IHHzd4F6 MojpPUBl[Xm| MVvDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDI[ZBIOiClZXzsd{Bi\nSncjC5JIRigXNiYomgUXRVKGG|c3H5MEBKSzVyPUK3Mlch|ryP M17I[FE4QDh6Nk[y
MDCK2 cells M4\Ke2Z2dmO2aX;uJIF{e2G7 NGns[XEyOCEQvF2= MknqTY5pcWKrdHnvckBw\iCqdX3hckBOWlB|IHX4dJJme3OnZDDpckBOTEONMjDj[YxteyCjc4Pld5Nm\CCjczDpcoNz\WG|ZTDpckBqdnS{YXPlcIx2dGG{IFPNSkBndHWxcnXzZ4Vv[2ViYYSgNVAhfU1iYomgR21HTEFiYYPzZZk> NHOxb5IyPzF5MkOxNS=>

... Click to View More Cell Line Experimental Data


Solubility (25°C)

In vitro DMSO 49 mg/mL (198.17 mM)
Water 49 mg/mL (198.17 mM)
Ethanol 9 mg/mL (36.4 mM)

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 247.25


CAS No. 143491-57-0
Storage powder
in solvent
Synonyms N/A

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03048422 Not yet recruiting HIV Infections National Institute of Allergy and Infectious Diseases (NIAID) April 30, 2017 Phase 3
NCT00524173 Recruiting Hepatitis B National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)|National Institutes of Health Clinical Center (CC) August 29, 2007 Phase 2
NCT03043326 Recruiting HIV Prevention Asociación Civil Impacta Salud y Educación, Peru|Gilead Sciences January 23, 2017 --
NCT02987530 Not yet recruiting HIV-1 Infection French National Institute for Health and Medical Research-French National Agency for Research on AIDS and Viral Hepatitis (Inserm-ANRS)|Institut National de la Santé Et de la Recherche Médicale, France January 2017 Phase 3
NCT02968576 Not yet recruiting Healthy Volunteers|Pharmacokinetics University of Colorado, Denver December 2016 --
NCT02984852 Recruiting Healthy Janssen Scientific Affairs, LLC December 2016 Phase 1

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Reverse Transcriptase Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID