Molecular Weight(MW): 329.4
Dapivirine (TMC120) is a non-nucleoside inhibitor for HIV reverse transcriptase with IC50 of 24 nM, inhibits a broad panel of HIV-1 isolates from different classes, inclucing a wide range of NNRTI-resistant isolates. Phase 3.
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|Description||Dapivirine (TMC120) is a non-nucleoside inhibitor for HIV reverse transcriptase with IC50 of 24 nM, inhibits a broad panel of HIV-1 isolates from different classes, inclucing a wide range of NNRTI-resistant isolates. Phase 3.|
Dapivirine prevents HIV-induced syncytium formation in the nanomolar range and shows a low cytostatic activity. Dapivirine apparently blocks HIV-1 infection in the primary cultures at a 10 nM concentration, but secondary cultures reveals that a 100 nM concentration is needed to completely prevent proviral integration.  Dapivirine is well tolerated by epithelial cells, T cells, macrophages, and cervical tissue explants with CC50 (50% cytotoxic concentration) of 10 μM to 20 μM. Dapivirine potently inhibits infection by both X4- and R5-utilizing HIV-1 strains with IC50 of 1.46 nM in cell-based assays. Dapivirine potently inhibits HIV-1BaL infection of human ectocervical explant tissue in a dose-dependent manner, as evaluated by the reduction in both p24 release and provirus content in cultured explants. Dapivirine inhibits the transmission of virus to permissive T cells in a dose-dependent manner, with an IC50 of 0.1 nM. Dapivirine results in significant inhibition of HIV infection when explants are challenged with virus immediately with IC90 of 100 nM. Dapivirine is also able to inhibit viral dissemination by migratory cells. 
|In vivo||Dapivirine-containing gel at vaginal level inhibits cell-associated HIV infection in mice.  More placebo (7 of 12) than Dapivirine (3 of 24) gel users has positive vaginal swab results, with white blood cells being the most common finding. Dapivirine (0.05%) results in Cmax of 715 pg/mL, AUC of 15 ng×h/mL and T1/2 of 89.87 hours in plasma after 14 days post-dose. Mean Dapivirine (0.05%) concentrations in vaginal fluids collected at the introitus, mid vagina, and cervix are in the range of 62-265 μg/g on day 1. |
|In vitro||DMSO||34 mg/mL (103.21 mM)|
* 1 mg/ml means slightly soluble or insoluble.
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Clinical Trial Information
|NCT Number||Recruitment||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT02658227||Not yet recruiting||HIV Infections||International Partnership for Microbicides, Inc.||February 2016||Phase 1|
|NCT02847286||Active, not recruiting||HIV- Prevention||International Partnership for Microbicides, Inc.||September 2015||Phase 1|
|NCT02808949||Active, not recruiting||Human Immunodeficiency Virus||International Partnership for Microbicides, Inc.||February 2015||Phase 1|
|NCT02028338||Enrolling by invitation||HIV Prevention||International Partnership for Microbicides, Inc.|Microbicide Trials Network|National Institutes of Health (NIH)||March 2014||Phase 2|
|NCT02010593||Completed||Safety/PK and Adherence/Acceptability||International Partnership for Microbicides, Inc.|National Institute of Allergy and Infectious Diseases (NIAID)||December 2013||Phase 2|
|NCT01952561||Not yet recruiting||Pharmacokinetics||International Partnership for Microbicides, Inc.||November 2013||Phase 1|
Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.
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