Sirtuin

Sigaling Pathway Map

Research Area

  • Inhibitory Selectivity
  • Solubility
Catalog No. Product Name Solubility(25°C)
Water DMSO Alcohol
S1129 SRT1720 HCl <1 mg/mL 38 mg/mL <1 mg/mL
S1541 Selisistat (EX 527) <1 mg/mL 49 mg/mL 18 mg/mL
S2804 Sirtinol <1 mg/mL 23 mg/mL <1 mg/mL
S1899 Nicotinamide (Vitamin B3) 24 mg/mL 24 mg/mL 24 mg/mL
S7845 SirReal2 <1 mg/mL 84 mg/mL <1 mg/mL
S8481 SRT3025 HCl <1 mg/mL 100 mg/mL 5 mg/mL
S8245 Thiomyristoyl <1 mg/mL 100 mg/mL 100 mg/mL
S8460 Salermide <1 mg/mL 78 mg/mL 7 mg/mL
S8270 SRT2183 <1 mg/mL 93 mg/mL 3 mg/mL
S4735 Salvianolic acid B 100 mg/mL 100 mg/mL 100 mg/mL
S4900 Tenovin-6 98 mg/mL 98 mg/mL <1 mg/mL
S7792 SRT2104 (GSK2245840) <1 mg/mL 16 mg/mL <1 mg/mL
S2391 Quercetin <1 mg/mL 61 mg/mL 10 mg/mL
S7577 AGK2 <1 mg/mL 10 mg/mL <1 mg/mL
S2298 Fisetin <1 mg/mL 57 mg/mL 3 mg/mL

Isoform-specific Inhibitors

Catalog No. Information Product Use Citations Product Validations
S1541

Selisistat (EX 527)

Selisistat (EX 527) is a potent and selective SIRT1 inhibitor with IC50 of 38 nM in a cell-free assay, exhibits >200-fold selectivity against SIRT2 and SIRT3. Phase 2.

S2804

Sirtinol

Sirtinol is a specific SIRT1 and SIRT2 inhibitor with IC50 of 131 μM and 38 μM in cell-free assays, respectively.

S1899

Nicotinamide (Vitamin B3)

Nicotinamide (Vitamin B3), a water-soluble vitamin, is an active component of coenzymes NAD and NADP, and also act as an inhibitor of sirtuins.

S7845

SirReal2

SirReal2 is a potent and selective Sirt2 inhibitor with IC50 of 140 nM.

S8245New

Thiomyristoyl

Thiomyristoyl is a potent and specific SIRT2 inhibitor with an IC50 of 28 nM. It inhibits SIRT1 with an IC50 value of 98 μM and does not inhibit SIRT3 even at 200 μM.

S8460New

Salermide

Salermide is a reverse amide with a strong in vitro inhibitory effect on Sirt1 and Sirt2. Compared with Sirt1, Salermide is even more efficient at inhibiting Sirt2.

S4900

Tenovin-6

Tenovin-6 is a small molecule activator of p53 transcriptional activity.

S7577

AGK2

AGK2 is a potent, and selective SIRT2 inhibitor with IC50 of 3.5 μM that minimally affects either SIRT1 or SIRT3 at 10-fold higher levels.

S1129

SRT1720 HCl

SRT1720 HCl is a selective SIRT1 activator with EC50 of 0.16 μM in a cell-free assay, but is >230-fold less potent for SIRT2 and SIRT3.

S8481New

SRT3025 HCl

SRT3025 is an orally available small molecule activator of the SIRT1 enzyme.

S8270New

SRT2183

SRT2183 is a small-molecule activator of the sirtuin subtype SIRT1, currently being developed by Sirtris Pharmaceuticals.

S4735New

Salvianolic acid B

Salvianolic acid B (Sal B), an antioxidant and free radical scavenging compound, is the most abundant bioactive compound extracted from the root of Salvia miltiorrhiza Bunge.

S7792

SRT2104 (GSK2245840)

SRT2104 (GSK2245840) is a selective SIRT1 activator involved in the regulation of energy homeostasis. Phase 2.

S2391

Quercetin

Quercetin, a natural flavonoid present in vegetables, fruit and wine, is a stimulator of recombinant SIRT1 and also a PI3K inhibitor with IC50 of 2.4-5.4 μM. Phase 4.

S2298

Fisetin

Fisetin (Fustel) is a potent sirtuin activating compound (STAC) and an agent that modulates sirtuins.

Catalog No. Information Product Use Citations Product Validations
S1541

Selisistat (EX 527)

Selisistat (EX 527) is a potent and selective SIRT1 inhibitor with IC50 of 38 nM in a cell-free assay, exhibits >200-fold selectivity against SIRT2 and SIRT3. Phase 2.

S2804

Sirtinol

Sirtinol is a specific SIRT1 and SIRT2 inhibitor with IC50 of 131 μM and 38 μM in cell-free assays, respectively.

S1899

Nicotinamide (Vitamin B3)

Nicotinamide (Vitamin B3), a water-soluble vitamin, is an active component of coenzymes NAD and NADP, and also act as an inhibitor of sirtuins.

S7845

SirReal2

SirReal2 is a potent and selective Sirt2 inhibitor with IC50 of 140 nM.

S8245New

Thiomyristoyl

Thiomyristoyl is a potent and specific SIRT2 inhibitor with an IC50 of 28 nM. It inhibits SIRT1 with an IC50 value of 98 μM and does not inhibit SIRT3 even at 200 μM.

S8460New

Salermide

Salermide is a reverse amide with a strong in vitro inhibitory effect on Sirt1 and Sirt2. Compared with Sirt1, Salermide is even more efficient at inhibiting Sirt2.

S4900

Tenovin-6

Tenovin-6 is a small molecule activator of p53 transcriptional activity.

S7577

AGK2

AGK2 is a potent, and selective SIRT2 inhibitor with IC50 of 3.5 μM that minimally affects either SIRT1 or SIRT3 at 10-fold higher levels.

Catalog No. Information Product Use Citations Product Validations
S1129

SRT1720 HCl

SRT1720 HCl is a selective SIRT1 activator with EC50 of 0.16 μM in a cell-free assay, but is >230-fold less potent for SIRT2 and SIRT3.

2015, 10.1038/nm.3821

2013, 32(6):791-804

2013, 74(1):298-308

S8481New

SRT3025 HCl

SRT3025 is an orally available small molecule activator of the SIRT1 enzyme.

S8270New

SRT2183

SRT2183 is a small-molecule activator of the sirtuin subtype SIRT1, currently being developed by Sirtris Pharmaceuticals.

S4735New

Salvianolic acid B

Salvianolic acid B (Sal B), an antioxidant and free radical scavenging compound, is the most abundant bioactive compound extracted from the root of Salvia miltiorrhiza Bunge.

S7792

SRT2104 (GSK2245840)

SRT2104 (GSK2245840) is a selective SIRT1 activator involved in the regulation of energy homeostasis. Phase 2.

S2391

Quercetin

Quercetin, a natural flavonoid present in vegetables, fruit and wine, is a stimulator of recombinant SIRT1 and also a PI3K inhibitor with IC50 of 2.4-5.4 μM. Phase 4.

S2298

Fisetin

Fisetin (Fustel) is a potent sirtuin activating compound (STAC) and an agent that modulates sirtuins.

2016, 40(10):2076-2084

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