AZD5363

Catalog No.S8019

AZD5363 Chemical Structure

Molecular Weight(MW): 428.92

AZD5363 potently inhibits all isoforms of Akt(Akt1/Akt2/Akt3) with IC50 of 3 nM/8 nM/8 nM in cell-free assays, similar to P70S6K/PKA and lower activity towards ROCK1/2. Phase 2.

Size Price Stock Quantity  
In DMSO USD 235 In stock
USD 147 In stock
USD 470 In stock
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4 Customer Reviews

  • G-H. Analysis of cells treated with AZD5363 (500 nM) for 24 hrs. G.Western analysis of whole cell lysates. H. Cells labeled with Annexin V-FITC for 6h were imaged. Individual points are average for replicates assessed in duplicate. Midlines are the average ± S.D. Student’s T-test.

    Cancer Res, 2016, 76(16):4752-64.. AZD5363 purchased from Selleck.

    (A) 239 cells stably expressing Flag-IL-17RA (293-IL-17RA cell line) were treated with 2 μM AZD5363 (a pan-Akt inhibitor) and/or 50 ng/ml insulin for the indicated time periods; Western blot analysis was performed for the indicated proteins; exogenous, IL-17RA transfected into 293 cells; endogenous, endogenous IL-17RA expressed in 293 cells.

    Oncotarget, 2016, 7(12):13651-66. AZD5363 purchased from Selleck.

  • Inhibition of PI3K and Akt by LY294002 and AZD5363 was confirmed by analyzing expression and activation status of the ribosomal protein S6 by Western blot analysis of PC-3 clone #14 cells treated with 0.5 or 5 uM AZD5363 (AZD) and 10 uM LY294002 (LY). Tubulin was used as a loading control.

    Cell Commun Signal 2014 12(1), 61. AZD5363 purchased from Selleck.

    LNCaP, LNCaP95, VCaP and 22Rv1 cells were transfected with control or pooled siRNA for AKT 1–3 isoforms for 36 hours. Cells were then further treated with 5 uM AZD5363 (B) for another 18 hours. Protein lysates were immunoblotted with AR (N-20), AR-V7, Pan-AKT, p-AKT(ser473) and β-Actin antibodies. Results were repeated in more than three independent experiments.

    PLoS One 2014 9(10), e108780. AZD5363 purchased from Selleck.

Purity & Quality Control

Choose Selective Akt Inhibitors

Biological Activity

Description AZD5363 potently inhibits all isoforms of Akt(Akt1/Akt2/Akt3) with IC50 of 3 nM/8 nM/8 nM in cell-free assays, similar to P70S6K/PKA and lower activity towards ROCK1/2. Phase 2.
Features Moderate preclinical tolerability, and PD characteristics of an AKT inhibitor. Distinct profile from other AKT inhibitors in clinical development.
Targets
Akt1 [1]
(Cell-free assay)
Akt2 [1]
(Cell-free assay)
Akt3 [1]
(Cell-free assay)
ROCK2 [1]
(Cell-free assay)
3 nM 8 nM 8 nM 56 nM
In vitro

AZD5363 is a potent Akt inhibitor with IC50 of 3 nM, 8 nM and 8 nM for Akt1, Akt2 and Akt3, respectively. [1] AZD5363 inhibits phosphorylation of AKT substrates in cells with a potency of approximately 0.3 to 0.8 μM. AZD5363 inhibits the proliferation of 41 of 182 solid and hematologic tumor cell lines with a potency of < 3 μM. [2] Activating mutations in PIK3CA, loss or inactivation of tumor suppressor PTEN, or HER2 amplification all are significantly predictive of responsiveness to AZD5363. Additionally, correlation is also seen between the RAS mutation status of cell lines and resistance to AZD5363. [1]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
MCF7 Mn7lS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkfTNlAxKG6P M{DtelYh\A>? MWfpcoNz\WG|ZXSg[JJ2\yC|ZX7zbZRqfmm2eTDv[kA1NU:KVDDhcoQh\nWudnXzeJJidnR? MknSNlY{PTF|MkO=
ZR75 MlTzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mk\3NVAxKG6P M2PKfFYh\A>? M4LYbYlv[3KnYYPl[EBlenWpIIPlcpNqfGm4aYT5JI9nKDRvT1jUJIFv\CCodXz2[ZN1emGwdB?= NGj0WlczPjN3MUOyNy=>
T74D Mmr2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1LsSFExOCCwTR?= MXm2JIQ> Mlq2bY5kemWjc3XkJIRzfWdic3Xud4l1cX[rdImgc4YhPC2RSGSgZY5lKG[3bI\ld5Rz[W62 MWOyOlM2OTN{Mx?=
1%MCF7 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mmq3OFAxKG6P M1;nO|Yh\A>? NGP2fohqdmO{ZXHz[YQh\HK3ZzDz[Y5{cXSrdnn0fUBw\iB2LV;IWEBidmRiZoXseoV{fHKjboS= NH[xUYgzPjN3MUOyNy=>
MCF7 LTED MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUmyNFAhdk1? Mn7nOkBl MUjpcoNz\WG|ZXSg[JJ2\yC|ZX7zbZRqfmm2eTDv[kA1NU:KVDDhcoQh\nWudnXzeJJidnR? Ml\WNlY{PTF|MkO=
ZR75 LTED NELiWGRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M324XFExOCCwTR?= NEW4UnA3KGR? MnTibY5kemWjc3XkJIRzfWdic3Xud4l1cX[rdImgc4YhPC2RSGSgZY5lKG[3bI\ld5Rz[W62 NHy2bWQzPjN3MUOyNy=>
T74D LTED NWX4NXdWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnnuNVAxKG6P NWDCZmdKPiCm MYPpcoNz\WG|ZXSg[JJ2\yC|ZX7zbZRqfmm2eTDv[kA1NU:KVDDhcoQh\nWudnXzeJJidnR? MUKyOlM2OTN{Mx?=
TamR NE\YeGxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MorBOFAxKG6P MYe2JIQ> MX\pcoNz\WG|ZXSg[JJ2\yC|ZX7zbZRqfmm2eTDv[kA1NU:KVDDhcoQh\nWudnXzeJJidnR? Mn7rNlY{PTF|MkO=
HCC1954 NVrZXoRNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF3Gb4oxNTFwM{Wg{txO MWe1JIQ> NHjIPXlmdmijbnPld{B1cGViZ4Lve5RpKGmwaHnibZRqd25ib3[gRXpFQDl|MR?= NVTxPG1xOjZyOUW0O|U>
BT474c NULWbJB1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmDNNE0yNjN3IN88US=> MVm1JIQ> NH7a[nNmdmijbnPld{B1cGViZ4Lve5RpKGmwaHnibZRqd25ib3[gRXpFQDl|MR?= NYfLc|BkOjZyOUW0O|U>
KPL4 NWPrNXJyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4PpR|AuOS5|NTFOwG0> MlHtOUBl NIDi[nlmdmijbnPld{B1cGViZ4Lve5RpKGmwaHnibZRqd25ib3[gRXpFQDl|MR?= NV7ZcHYzOjZyOUW0O|U>
SKBR3 MojiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NU\YOIREOC1zLkO1JO69VQ>? NH\IeFc2KGR? MnKx[Y5p[W6lZYOgeIhmKGe{b4f0bEBqdmirYnn0bY9vKG:oIFHaSFg6OzF? NHrUWlgzPjB7NUS3OS=>
MR49C M3rnXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3HwTFAuPSEQvF2= Ml65OFghcA>? NGeydFZqdmirYnn0d{Bk\WyuIHfyc5d1cCCrbjDhJIRwe2ViZHXw[Y5l\W62IH3hco5meg>? MXeyOVE2OTBzMh?=
MR49F MkjSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{\SSFAuPSEQvF2= MkfSOFghcA>? M2LLcIlvcGmkaYTzJINmdGxiZ4Lve5RpKGmwIHGg[I9{\SCmZYDlcoRmdnRibXHucoVz NXm4W|J{OjVzNUGwNVI>
NCI-H522 NWHFXlVRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX;jdJZoUUN3ME2xNU4{KCkEsUKuO{kh|ryP MVyyOFk2PzZ6Mh?=
PC-9 NVPadXVFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVfJR|UxRTlwMzCoxtEyNjJrIN88US=> NFnu[HQzPDl3N{[4Ni=>
NCI-H522 NXTLXYNETnWwY4Tpc44hSXO|YYm= NXnC[mw2OS93L{GwJO69VQ>? MXm0M|I1KGh? Mn;2bY5kemWjc3XzJGFMXCCyaH;zdIhwenmuYYTpc44> NWPHb2tXOjR7NUe2PFI>
PC-9 M{jo[GZ2dmO2aX;uJGF{e2G7 NI\JfVEyNzVxMUCg{txO M3ricVQwOjRiaB?= MXrpcoNz\WG|ZYOgRWtVKHCqb4PwbI9zgWyjdHnvci=> NFLReZMzPDl3N{[4Ni=>
HGC27 NGHBXFhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEnMN3FKSzVyPUCuOFQ2KM7:TR?= MXqyOFA5QDN6Mh?=
IM95m MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mkm3TWM2OD1yLkWxJO69VQ>? M{XwflI1ODh6M{iy
AGS M4PRc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2TpVGlEPTB;MD61OVIh|ryP Ml7SNlQxQDh|OEK=
NCI-N87 NUnZRXhQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3XHSmlEPTB;MT6wN|ch|ryP M4THNFI1ODh6M{iy
23132/87 NXTtd3JLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYO1V3M2UUN3ME2xMlY4OSEQvF2= M4PuVlI1ODh6M{iy
MKN1 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXLJR|UxRTJwNEKxJO69VQ>? NIrvO3EzPDB6OEO4Ni=>
SNU-620 MlLrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mm\DTWM2OD1|LkO4OEDPxE1? MkizNlQxQDh|OEK=
SNU-638 NVzLfZZET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M13y[2lEPTB;ND61NlMh|ryP MWWyOFA5QDN6Mh?=
SNU-1 NH\TT5BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn3HTWM2OD13LkK1PEDPxE1? Mk\lNlQxQDh|OEK=
SNU-601 MkPCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUjJR|UxRTVwOUO4JO69VQ>? NGH2OFYzPDB6OEO4Ni=>
SNU-668 Mlf0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVPNWlNRUUN3ME22MlAxOyEQvF2= MWGyOFA5QDN6Mh?=
HS746T MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn2wTWM2OD14LkC4OEDPxE1? MoLoNlQxQDh|OEK=
KATO III MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnjFTWM2OD15LkK2O{DPxE1? NX7BUGU6OjRyOEizPFI>
SNU-484 MoP0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2[0OGlEPTB;Nz6zPVIh|ryP MlnhNlQxQDh|OEK=
SNU-16 M3vXTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFXHW5NKSzVyPUGxMlA6PyEQvF2= M2HnRlI1ODh6M{iy
OCUM-1 Mm\0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWTwcnN6UUN3ME2xOE42OTVizszN M4DRZVI1ODh6M{iy
NUGC-3 M2XKfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1\VdGlEPTB;MkGuPFc{KM7:TR?= MmjsNlQxQDh|OEK=
AZ521 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHLOdnNKSzVyPUK1MlQ1QCEQvF2= M2KxRVI1ODh6M{iy
SNU-216 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWfCSZhvUUN3ME2zNEDPxE1? NEDWZ5gzPDB6OEO4Ni=>
NUGC-4 NXK5co55T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4XGXWlEPTB;M{Cg{txO MoPPNlQxQDh|OEK=
SNU-5 NITVSFRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MW\JR|UxRTNyIN88US=> M1fwRlI1ODh6M{iy
GTL-16 M1q4cmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NInjb4dKSzVyPUOwJO69VQ>? NE[yRoMzPDB6OEO4Ni=>
MKN74 NWntNmlXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWnJR|UxRTNyIN88US=> MmPFNlQxQDh|OEK=
PAMC82 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYjJR|UxRTNyIN88US=> NID0VGwzPDB6OEO4Ni=>
LNCaP MlX3SpVv[3Srb36gRZN{[Xl? NE\wZpM2KM7:TR?= MVewMVI1KGh? MnH1bY5lfWOnczDBT3RUPDd|IHHu[EBCU1SWM{C4JJBpd3OyaH;yfYxifGmxbjDpckBiKHSrbXWg[IVx\W6mZX70JI1idm6nch?= NILuTmIzOzl4Nk[yNS=>
C4-2  NXXVXnA6TnWwY4Tpc44hSXO|YYm= MoHzOUDPxE1? MYKwMVI1KGh? NFXDW5RqdmS3Y3XzJGFMXFN2N{OgZY5lKEGNVGSzNFgheGixc4Doc5J6dGG2aX;uJIlvKGFidHnt[UBl\XCnbnTlcpQhdWGwbnXy MX2yN|k3PjZ{MR?=
LNCaP NV;Fb3p6TnWwY4Tpc44hSXO|YYm= NWXDUGFmPSEQvF2= MUWwMVI1KGh? NFK3OZNqdmirYnn0d{BxcG:|cHjvdplt[XSrb36gc4YhfGinIHTpd5RidCCDS2StdIF1cHejeTDibY9u[XKtZYLzJIlv[2y3ZHnu[{BRWkGVNECsJIVKTjSHLDC0SU1DWDFuIH3UU3ItKGGwZDDQO|AhWzZia3nuZZNmKGmwIHGgeIlu\S2mZYDlcoRmdnRibXHucoVz NV;MN|YyOjN7Nk[2NlE>
C4-2  NGn3fYxHfW6ldHnvckBCe3OjeR?= NWD4UmRmPSEQvF2= MkLtNE0zPCCq M2fNOYlvcGmkaYTzJJBpd3OyaH;yfYxifGmxbjDv[kB1cGViZHnzeIFtKEGNVD3wZZRpf2G7IHLpc41iemuncoOgbY5kdHWmaX7nJHBTSVN2MDyg[WlHPEVuIETFMWJROSxibWTPVkwh[W6mIGC3NEBUPiCtaX7hd4UhcW5iYTD0bY1mNWSncHXu[IVvfCCvYX7u[ZI> MUOyN|k3PjZ{MR?=
LNCaP NVjxbmZrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWexMVExODByIH7N NHnL[5oxNTNiZB?= MkOybY5pcWKrdIOgZ4VtdCC4aXHibYxqfHliZH;z[UBl\XCnbnTlcpRtgQ>? MVKyN|k3PjZ{MR?=
C4-2  M3XYWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2HYcVEuOTByMECgcm0> NEDBZ5cxNTNiZB?= MnvGbY5pcWKrdIOgZ4VtdCC4aXHibYxqfHliZH;z[UBl\XCnbnTlcpRtgQ>? MnvFNlM6PjZ4MkG=
LNCaP NEewTI5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MU[xNFAuPTByMDDuUS=> M{\Md|czKGh? NI\VWFZqdmO{ZXHz[ZMhfGinIH\yZYN1cW:wIH;mJINmdGy|IIXu[IVz\2:rbnegZ4VtdCCmZXH0bC=> NHTteZIzOzl4Nk[yNS=>
C4-2  M2LESWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF22fZAyODBvNUCwNEBvVQ>? NEHH[484OiCq M3jYW4lv[3KnYYPld{B1cGViZoLhZ5Rqd25ib3[gZ4VtdHNidX7k[ZJod2mwZzDj[YxtKGSnYYTo NF;yN3kzOzl4Nk[yNS=>
PC-3 NFSwUnFHfW6ldHnvckBCe3OjeR?= MoP0NE42NzFxMUCg{txO NYT6eoFjPDhiaB?= MXfkc5dvemWpdXzheIV{KHSqZTDwbI9{eGixconsZZRqd25ib3[g[I94dnO2cnXhcUBx[XSqd3H5JJBzd3SnaX7zJIlvKGFiZH;z[U1l\XCnbnTlcpQhdWGwbnXy M3nOelI{OjV6N{Sw
DU145  MVXGeY5kfGmxbjDBd5NigQ>? Mlm0NE42NzFxMUCg{txO Mn\zOFghcA>? NIPsclBld3ewcnXneYxifGW|IITo[UBxcG:|cHjvdplt[XSrb36gc4Yh\G:5boP0doVidSCyYYToe4F6KHC{b4TlbY5{KGmwIHGg[I9{\S2mZYDlcoRmdnRibXHucoVz NHPCcmszOzJ3OEe0NC=>
LNCaP Ml[zR4VtdCCYaXHibYxqfHliQYPzZZk> NH7ydIQxNTFyMECgcm0> MW[wMVQh\A>? M1jkTpJm\HWlZXSgUG5E[VBiY3XscEB3cWGkaXzpeJkhcW5iYTDkc5NmNSCjbnSgeIlu\S2mZYDlcoRmdnRibXHucoVzyqB? M3;NVFI{OjV6N{Sw
PC-3  NIjXR3VHfW6ldHnvckBCe3OjeR?= NX\hWGtKOTBizszN MlvtNVIhcA>? NHv3ZXhqdmS3Y3XzJIF2fG:yaHHnfS=> NIO1TWwzOzJ3OEe0NC=>

... Click to View More Cell Line Experimental Data

In vivo Oral dosing of AZD5363 (100, 300 mg/kg) to nude mice causes dose- and time-dependent reduction of PRAS40, GSK3β, and S6 phosphorylation in BT474c xenografts, reversible increases in blood glucose concentrations, and dose-dependent decreases in 2[18F]fluoro-2-deoxy-d-glucose (18F-FDG) uptake in U87-MG xenografts. Chronic oral dosing of AZD5363 (130, 200, and 300 mg/kg) causes dose-dependent growth inhibition of xenografts derived from various tumor types, including HER2+ breast cancer models that are resistant to trastuzumab. AZD5363 also significantly enhances the antitumor activity of docetaxel, lapatinib, and trastuzumab in breast cancer xenografts. [2]

Protocol

Kinase Assay:[1]
+ Expand

Caliper Off-Chip Incubation Mobility Shift assay:

The ability of AZD5363 and other compounds to inhibit the activity of AKT1, AKT2, and AKT3 is evaluated by the Caliper Off-Chip Incubation Mobility Shift assay. Active recombinant AKT1, AKT2, or AKT3 are incubated with a 5-FAM-labeled custom-synthesized peptide substrate together with increasing concentrations of inhibitor. Final reactions contained 1 to 3 nM AKT1, AKT2, or AKT3 enzymes; 1.5 mM peptide substrate; ATP at K m for each AKT isoform; 10 mM MgCl2, 4 mM DTT, 100 mM HEPES, and 0.015% Brij-35. The reactions are incubated at room temperature for 1 hour and stopped by the addition of buffer containing 100 mM HEPES, 0.015% Brij-35 solution, 0.1% coating reagent, 40 mM EDTA, and 5% DMSO. Plates are then analyzed using a Caliper LC3000, allowing for separation of peptide substrate and phosphorylated product by electrophoresis with subsequent detection and quantification of laser induced fluorescence.
Cell Research: [2]
+ Expand
  • Cell lines: 182 solid and hematologic tumor cell lines
  • Concentrations: ~30 μM
  • Incubation Time: 72 hours
  • Method: Cell proliferation assay is determined by 2 methods, MTS and Sytox Green. Briefly, cells are seeded in 96-well plates and incubated overnight at 37 ℃, 5% CO2. Cells are then exposed to concentrations of AZD5363 ranging from 30 to 0.003μM for 72 hours. For the MTS endpoint, cell proliferation is measured by the CellTiter AQueous Non-Radioactive Cell Proliferation Assay reagent in accordance with the manufacturer's protocol. For the Sytox Green endpoint, Sytox Green nucleic acid dye diluted in TBS-EDTA buffer is added to cells (final concentration of 0.13 μM) and the number of dead cells detected using an Acumen Explorer. Cells are then permeabilized by the addition of saponin (0.03% final concentration, diluted in TBS-EDTA buffer), incubated overnight and a total cell count measured. Predose measurements are made for both MTS and Sytox Green endpoints, and concentration needed to reduce the growth of treated cells to half that of untreated cells values are determined using absorbance readings (MTS) or live cell counts.
    (Only for Reference)
Animal Research:[2]
+ Expand
  • Animal Models: Female nude mice and male SCID mice with BT474c, U87MG, KPL-4, HCC-1187 xenografts.
  • Formulation: In 10% DMSO 25% w/v Kleptose HPB
  • Dosages: 130 mg/Kg - 300 mg/Kg
  • Administration: p.o.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 86 mg/mL (200.5 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
1% CMC Na
For best results, use promptly after mixing.
30mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 428.92
Formula

C21H25ClN6O2

CAS No. 1143532-39-1
Storage powder
in solvent
Synonyms N/A

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02576444 Recruiting Cancer Joseph Paul Eder|Dana-Farber Cancer Institute|Vanderbilt-Ingram Cancer Center|Yale University November 2015 Phase 2
NCT02465060 Recruiting Advanced Malignant Neoplasm|Lymphoma|Recurrent Plasma Cell Myeloma|Recurrent Solid Neoplasm|Refractory Malignant Neoplasm|Refractory Plasma Cell Myeloma National Cancer Institute (NCI) August 2015 Phase 2
NCT02664935 Recruiting Non-Small Cell Lung Cancer|Carcinoma, Squamous Cell|Adenocarcinoma University of Birmingham|Cancer Research UK|AstraZeneca|Pfizer|Experimental Cancer Medicine Centre Network March 2015 Phase 2
NCT02451956 Recruiting Advanced Gastric Cancer Samsung Medical Center January 2015 Phase 2
NCT02525068 Recruiting Adenocarcinoma of the Prostate Institute of Cancer Research, United Kingdom|Royal Marsden NHS Foundation Trust December 2014 Phase 2
NCT02208375 Recruiting Breast Cancer|Malignant Female Reproductive System Neoplasm M.D. Anderson Cancer Center|AstraZeneca|National Cancer Institute (NCI) November 2014 Phase 1|Phase 2

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID