AZD5363

Catalog No.S8019

AZD5363 Chemical Structure

Molecular Weight(MW): 428.92

AZD5363 potently inhibits all isoforms of Akt(Akt1/Akt2/Akt3) with IC50 of 3 nM/8 nM/8 nM in cell-free assays, similar to P70S6K/PKA and lower activity towards ROCK1/2. Phase 2.

Size Price Stock Quantity  
In DMSO USD 235 In stock
USD 147 In stock
USD 470 In stock
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4 Customer Reviews

  • G-H. Analysis of cells treated with AZD5363 (500 nM) for 24 hrs. G.Western analysis of whole cell lysates. H. Cells labeled with Annexin V-FITC for 6h were imaged. Individual points are average for replicates assessed in duplicate. Midlines are the average ± S.D. Student’s T-test.

    Cancer Res, 2016, 76(16):4752-64.. AZD5363 purchased from Selleck.

    (A) 239 cells stably expressing Flag-IL-17RA (293-IL-17RA cell line) were treated with 2 μM AZD5363 (a pan-Akt inhibitor) and/or 50 ng/ml insulin for the indicated time periods; Western blot analysis was performed for the indicated proteins; exogenous, IL-17RA transfected into 293 cells; endogenous, endogenous IL-17RA expressed in 293 cells.

    Oncotarget, 2016, 7(12):13651-66. AZD5363 purchased from Selleck.

  • Inhibition of PI3K and Akt by LY294002 and AZD5363 was confirmed by analyzing expression and activation status of the ribosomal protein S6 by Western blot analysis of PC-3 clone #14 cells treated with 0.5 or 5 uM AZD5363 (AZD) and 10 uM LY294002 (LY). Tubulin was used as a loading control.

    Cell Commun Signal 2014 12(1), 61. AZD5363 purchased from Selleck.

    LNCaP, LNCaP95, VCaP and 22Rv1 cells were transfected with control or pooled siRNA for AKT 1–3 isoforms for 36 hours. Cells were then further treated with 5 uM AZD5363 (B) for another 18 hours. Protein lysates were immunoblotted with AR (N-20), AR-V7, Pan-AKT, p-AKT(ser473) and β-Actin antibodies. Results were repeated in more than three independent experiments.

    PLoS One 2014 9(10), e108780. AZD5363 purchased from Selleck.

Purity & Quality Control

Choose Selective Akt Inhibitors

Biological Activity

Description AZD5363 potently inhibits all isoforms of Akt(Akt1/Akt2/Akt3) with IC50 of 3 nM/8 nM/8 nM in cell-free assays, similar to P70S6K/PKA and lower activity towards ROCK1/2. Phase 2.
Features Moderate preclinical tolerability, and PD characteristics of an AKT inhibitor. Distinct profile from other AKT inhibitors in clinical development.
Targets
Akt1 [1]
(Cell-free assay)
Akt2 [1]
(Cell-free assay)
Akt3 [1]
(Cell-free assay)
ROCK2 [1]
(Cell-free assay)
3 nM 8 nM 8 nM 56 nM
In vitro

AZD5363 is a potent Akt inhibitor with IC50 of 3 nM, 8 nM and 8 nM for Akt1, Akt2 and Akt3, respectively. [1] AZD5363 inhibits phosphorylation of AKT substrates in cells with a potency of approximately 0.3 to 0.8 μM. AZD5363 inhibits the proliferation of 41 of 182 solid and hematologic tumor cell lines with a potency of < 3 μM. [2] Activating mutations in PIK3CA, loss or inactivation of tumor suppressor PTEN, or HER2 amplification all are significantly predictive of responsiveness to AZD5363. Additionally, correlation is also seen between the RAS mutation status of cell lines and resistance to AZD5363. [1]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
MCF7 NVrmdHc5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHPHcmszODBibl2= M3G0dlYh\A>? NID2cFRqdmO{ZXHz[YQh\HK3ZzDz[Y5{cXSrdnn0fUBw\iB2LV;IWEBidmRiZoXseoV{fHKjboS= NWH3XmhWOjZ|NUGzNlM>
ZR75 MkLtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEixb3QyODBibl2= M17XSFYh\A>? MYHpcoNz\WG|ZXSg[JJ2\yC|ZX7zbZRqfmm2eTDv[kA1NU:KVDDhcoQh\nWudnXzeJJidnR? M2C1OVI3OzVzM{Kz
T74D M3Tudmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXyxNFAhdk1? NFv2Z2k3KGR? M2\Cd4lv[3KnYYPl[EBlenWpIIPlcpNqfGm4aYT5JI9nKDRvT1jUJIFv\CCodXz2[ZN1emGwdB?= MXGyOlM2OTN{Mx?=
1%MCF7 NUDhe41GT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mlm5OFAxKG6P MUS2JIQ> NEjQcG1qdmO{ZXHz[YQh\HK3ZzDz[Y5{cXSrdnn0fUBw\iB2LV;IWEBidmRiZoXseoV{fHKjboS= MYmyOlM2OTN{Mx?=
MCF7 LTED MnO3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkHyNlAxKG6P NWPaR|hoPiCm NEPkeJNqdmO{ZXHz[YQh\HK3ZzDz[Y5{cXSrdnn0fUBw\iB2LV;IWEBidmRiZoXseoV{fHKjboS= MWSyOlM2OTN{Mx?=
ZR75 LTED MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4XqU|ExOCCwTR?= NWrZfYJEPiCm NUTqWVNzcW6lcnXhd4VlKGS{dXegd4Vve2m2aY\peJkhd2ZiND3PTHQh[W6mIH\1cJZme3S{YX70 MVSyOlM2OTN{Mx?=
T74D LTED NGW5UJlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml3zNVAxKG6P NUC2[mtsPiCm NXrz[pY6cW6lcnXhd4VlKGS{dXegd4Vve2m2aY\peJkhd2ZiND3PTHQh[W6mIH\1cJZme3S{YX70 M2G3NFI3OzVzM{Kz
TamR M1nOcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHTleGY1ODBibl2= M{\lblYh\A>? NXHtfpNLcW6lcnXhd4VlKGS{dXegd4Vve2m2aY\peJkhd2ZiND3PTHQh[W6mIH\1cJZme3S{YX70 NEjLdmYzPjN3MUOyNy=>
HCC1954 M3fnPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVmwMVEvOzVizszN NF;nS|A2KGR? NFn6XmNmdmijbnPld{B1cGViZ4Lve5RpKGmwaHnibZRqd25ib3[gRXpFQDl|MR?= M{HLe|I3ODl3NEe1
BT474c NX24dXBvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3nhZVAuOS5|NTFOwG0> MX[1JIQ> NYDiVYNq\W6qYX7j[ZMhfGinIHfyc5d1cCCrbnjpZol1cW:wIH;mJGFbTDh7M{G= NUDqe2xPOjZyOUW0O|U>
KPL4 NX3hUIN[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2f2TlAuOS5|NTFOwG0> NF\MR2s2KGR? M37sXIVvcGGwY3XzJJRp\SCpcn;3eIghcW6qaXLpeIlwdiCxZjDBXmQ5QTNz MkP2NlYxQTV2N{W=
SKBR3 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIj3fHMxNTFwM{Wg{txO M1HZSVUh\A>? NWn1dZUy\W6qYX7j[ZMhfGinIHfyc5d1cCCrbnjpZol1cW:wIH;mJGFbTDh7M{G= MlXtNlYxQTV2N{W=
MR49C MlrMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHSwTHoxNTVizszN NYKzbZJwPDhiaB?= NXvlRmVkcW6qaXLpeJMh[2WubDDndo94fGhiaX6gZUBld3OnIHTldIVv\GWwdDDtZY5v\XJ? NEDOPIIzPTF3MUCxNi=>
MR49F NI\GcZJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmjqNE02KM7:TR?= MX20PEBp M4XCdIlvcGmkaYTzJINmdGxiZ4Lve5RpKGmwIHGg[I9{\SCmZYDlcoRmdnRibXHucoVz NFO4fJYzPTF3MUCxNi=>
NCI-H522 Mn25S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIC3[GlKSzVyPUGxMlMhMMLzMj63LUDPxE1? NEDGdGgzPDl3N{[4Ni=>
PC-9 MlrnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHL4eYlKSzVyPUmuN{ApyrFzLkKpJO69VQ>? M17C[lI1QTV5Nkiy
NCI-H522 M4fXS2Z2dmO2aX;uJGF{e2G7 NXjQcI5lOS93L{GwJO69VQ>? M1PpPVQwOjRiaB?= NWDPe41qcW6lcnXhd4V{KEGNVDDwbI9{eGixconsZZRqd25? NFfpUYMzPDl3N{[4Ni=>
PC-9 NWCzXnZbTnWwY4Tpc44hSXO|YYm= NEmzOpUyNzVxMUCg{txO MlPMOE8zPCCq M2X3SYlv[3KnYYPld{BCU1RicHjvd5Bpd3K7bHH0bY9v NWPv[oltOjR7NUe2PFI>
HGC27 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHrRSJNKSzVyPUCuOFQ2KM7:TR?= M1vJVVI1ODh6M{iy
IM95m M4HTZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2rQ[WlEPTB;MD61NUDPxE1? NUfJfFQ{OjRyOEizPFI>
AGS MoHkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmXpTWM2OD1yLkW1NkDPxE1? M3m3XFI1ODh6M{iy
NCI-N87 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEn3T2FKSzVyPUGuNFM4KM7:TR?= MWCyOFA5QDN6Mh?=
23132/87 MlHzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFXpZXJKSzVyPUGuOlcyKM7:TR?= NILqcYczPDB6OEO4Ni=>
MKN1 MoTWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWDNdHRJUUN3ME2yMlQzOSEQvF2= NULofHlSOjRyOEizPFI>
SNU-620 MorGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGnwbXFKSzVyPUOuN|g1KM7:TR?= MnH5NlQxQDh|OEK=
SNU-638 NWnnbVF4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGXhcmJKSzVyPUSuOVI{KM7:TR?= M{jOS|I1ODh6M{iy
SNU-1 NXHPSYdWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYfIUnA2UUN3ME21MlI2QCEQvF2= NFXJfY8zPDB6OEO4Ni=>
SNU-601 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXXJR|UxRTVwOUO4JO69VQ>? NUnQO4w1OjRyOEizPFI>
SNU-668 NVy1e3o5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV7aN3NrUUN3ME22MlAxOyEQvF2= MVSyOFA5QDN6Mh?=
HS746T NEfEZphIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV\JR|UxRTZwMEi0JO69VQ>? MYqyOFA5QDN6Mh?=
KATO III NVzBZ3RsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX7JR|UxRTdwMk[3JO69VQ>? M17tTVI1ODh6M{iy
SNU-484 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVHEV211UUN3ME23MlM6OiEQvF2= MXOyOFA5QDN6Mh?=
SNU-16 M13WNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkT1TWM2OD1zMT6wPVch|ryP NGqwW|IzPDB6OEO4Ni=>
OCUM-1 NHvOOIxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYjlVlZtUUN3ME2xOE42OTVizszN NGHoOmIzPDB6OEO4Ni=>
NUGC-3 NXe4XZJYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlTjTWM2OD1{MT64O|Mh|ryP NHLGOlAzPDB6OEO4Ni=>
AZ521 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnT5TWM2OD1{NT60OFgh|ryP MVuyOFA5QDN6Mh?=
SNU-216 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVzJR|UxRTNyIN88US=> NVf4SmR7OjRyOEizPFI>
NUGC-4 MlzkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2PuXmlEPTB;M{Cg{txO M1\qUVI1ODh6M{iy
SNU-5 NX7hZ25yT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnvhTWM2OD1|MDFOwG0> NWHveI8yOjRyOEizPFI>
GTL-16 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVTFXW5{UUN3ME2zNEDPxE1? MVmyOFA5QDN6Mh?=
MKN74 M1zwc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3\RVmlEPTB;M{Cg{txO NYXQ[GNMOjRyOEizPFI>
PAMC82 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkHCTWM2OD1|MDFOwG0> M3nkcFI1ODh6M{iy
LNCaP Mnn1SpVv[3Srb36gRZN{[Xl? Ml\WOUDPxE1? MVqwMVI1KGh? NYLyTYlCcW6mdXPld{BCU1SVNEezJIFv\CCDS2TUN|A5KHCqb4PwbI9zgWyjdHnvckBqdiCjIITpcYUh\GWyZX7k[Y51KG2jbn7ldi=> MorhNlM6PjZ4MkG=
C4-2  MVXGeY5kfGmxbjDBd5NigQ>? NEixbFM2KM7:TR?= NWDl[3Y5OC1{NDDo MXLpcoR2[2W|IFHLWHM1PzNiYX7kJGFMXFR|MEigdIhwe3Cqb4L5cIF1cW:wIHnuJIEhfGmvZTDk[ZBmdmSnboSgcYFvdmW{ MmfTNlM6PjZ4MkG=
LNCaP NI\welJHfW6ldHnvckBCe3OjeR?= MknBOUDPxE1? NFvVT48xNTJ2IHi= MkXrbY5pcWKrdIOgdIhwe3Cqb4L5cIF1cW:wIH;mJJRp\SCmaYP0ZYwhSUuWLYDheIh4[XliYnnvcYFzc2W{czDpcoNtfWSrbnegVHJCWzRyLDDlTWY1TSxiNFWtRnAyNCCvVF;SMEBidmRiUEewJHM3KGurbnHz[UBqdiCjIITpcYUu\GWyZX7k[Y51KG2jbn7ldi=> NXzMcZNoOjN7Nk[2NlE>
C4-2  NVTGUnYzTnWwY4Tpc44hSXO|YYm= NXLM[ZBsPSEQvF2= NFfySogxNTJ2IHi= NV;PVWM6cW6qaXLpeJMheGixc4Doc5J6dGG2aX;uJI9nKHSqZTDkbZN1[WxiQVvUMZBifGi5YYmgZolwdWG{a3Xyd{BqdmOudXTpcochWFKDU{SwMEBmUUZ2RTygOGUuSlBzLDDtWG9TNCCjbnSgVFcxKFN4IHvpcoF{\SCrbjDhJJRqdWVvZHXw[Y5l\W62IH3hco5meg>? MUGyN|k3PjZ{MR?=
LNCaP NXf0WHBST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGnzSFcyNTFyMECwJI5O MUmwMVMh\A>? NWTTcnJPcW6qaXLpeJMh[2WubDD2bYFjcWyrdImg[I9{\SCmZYDlcoRmdnSueR?= MoLsNlM6PjZ4MkG=
C4-2  NVuw[2hST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmrhNU0yODByMDDuUS=> NX3zRWhJOC1|IHS= M17JPIlvcGmkaYTzJINmdGxidnnhZoltcXS7IHTvd4Uh\GWyZX7k[Y51dHl? NYXEc3RJOjN7Nk[2NlE>
LNCaP M3H3SWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX6xNFAuPTByMDDuUS=> MoCwO|IhcA>? NHv6TnlqdmO{ZXHz[ZMhfGinIH\yZYN1cW:wIH;mJINmdGy|IIXu[IVz\2:rbnegZ4VtdCCmZXH0bC=> MXiyN|k3PjZ{MR?=
C4-2  MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGHLfHAyODBvNUCwNEBvVQ>? NVrxcGNWPzJiaB?= NFXCcWVqdmO{ZXHz[ZMhfGinIH\yZYN1cW:wIH;mJINmdGy|IIXu[IVz\2:rbnegZ4VtdCCmZXH0bC=> M2XoPVI{QTZ4NkKx
PC-3 MoTJSpVv[3Srb36gRZN{[Xl? NYPzc4dVOC53L{GvNVAh|ryP NGroRVY1QCCq NIfGTXRld3ewcnXneYxifGW|IITo[UBxcG:|cHjvdplt[XSrb36gc4Yh\G:5boP0doVidSCyYYToe4F6KHC{b4TlbY5{KGmwIHGg[I9{\S2mZYDlcoRmdnRibXHucoVz M3OycVI{OjV6N{Sw
DU145  MUPGeY5kfGmxbjDBd5NigQ>? NIW3S44xNjVxMT:xNEDPxE1? NULyT2Y2PDhiaB?= MV7kc5dvemWpdXzheIV{KHSqZTDwbI9{eGixconsZZRqd25ib3[g[I94dnO2cnXhcUBx[XSqd3H5JJBzd3SnaX7zJIlvKGFiZH;z[U1l\XCnbnTlcpQhdWGwbnXy MXqyN|I2QDd2MB?=
LNCaP NXjsS3dMS2WubDDWbYFjcWyrdImgRZN{[Xl? NFvWWpAxNTFyMECgcm0> MUSwMVQh\A>? NFXzUpRz\WS3Y3XkJGxPS2GSIHPlcIwhfmmjYnnsbZR6KGmwIHGg[I9{\S1iYX7kJJRqdWVvZHXw[Y5l\W62IH3hco5mesLi NWDSTHJuOjN{NUi3OFA>
PC-3  NFz5ZYJHfW6ldHnvckBCe3OjeR?= MnXFNVAh|ryP NGLOT2EyOiCq MUjpcoR2[2W|IHH1eI9xcGGpeR?= NGDESVEzOzJ3OEe0NC=>

... Click to View More Cell Line Experimental Data

In vivo Oral dosing of AZD5363 (100, 300 mg/kg) to nude mice causes dose- and time-dependent reduction of PRAS40, GSK3β, and S6 phosphorylation in BT474c xenografts, reversible increases in blood glucose concentrations, and dose-dependent decreases in 2[18F]fluoro-2-deoxy-d-glucose (18F-FDG) uptake in U87-MG xenografts. Chronic oral dosing of AZD5363 (130, 200, and 300 mg/kg) causes dose-dependent growth inhibition of xenografts derived from various tumor types, including HER2+ breast cancer models that are resistant to trastuzumab. AZD5363 also significantly enhances the antitumor activity of docetaxel, lapatinib, and trastuzumab in breast cancer xenografts. [2]

Protocol

Kinase Assay:[1]
+ Expand

Caliper Off-Chip Incubation Mobility Shift assay:

The ability of AZD5363 and other compounds to inhibit the activity of AKT1, AKT2, and AKT3 is evaluated by the Caliper Off-Chip Incubation Mobility Shift assay. Active recombinant AKT1, AKT2, or AKT3 are incubated with a 5-FAM-labeled custom-synthesized peptide substrate together with increasing concentrations of inhibitor. Final reactions contained 1 to 3 nM AKT1, AKT2, or AKT3 enzymes; 1.5 mM peptide substrate; ATP at K m for each AKT isoform; 10 mM MgCl2, 4 mM DTT, 100 mM HEPES, and 0.015% Brij-35. The reactions are incubated at room temperature for 1 hour and stopped by the addition of buffer containing 100 mM HEPES, 0.015% Brij-35 solution, 0.1% coating reagent, 40 mM EDTA, and 5% DMSO. Plates are then analyzed using a Caliper LC3000, allowing for separation of peptide substrate and phosphorylated product by electrophoresis with subsequent detection and quantification of laser induced fluorescence.
Cell Research: [2]
+ Expand
  • Cell lines: 182 solid and hematologic tumor cell lines
  • Concentrations: ~30 μM
  • Incubation Time: 72 hours
  • Method: Cell proliferation assay is determined by 2 methods, MTS and Sytox Green. Briefly, cells are seeded in 96-well plates and incubated overnight at 37 ℃, 5% CO2. Cells are then exposed to concentrations of AZD5363 ranging from 30 to 0.003μM for 72 hours. For the MTS endpoint, cell proliferation is measured by the CellTiter AQueous Non-Radioactive Cell Proliferation Assay reagent in accordance with the manufacturer's protocol. For the Sytox Green endpoint, Sytox Green nucleic acid dye diluted in TBS-EDTA buffer is added to cells (final concentration of 0.13 μM) and the number of dead cells detected using an Acumen Explorer. Cells are then permeabilized by the addition of saponin (0.03% final concentration, diluted in TBS-EDTA buffer), incubated overnight and a total cell count measured. Predose measurements are made for both MTS and Sytox Green endpoints, and concentration needed to reduce the growth of treated cells to half that of untreated cells values are determined using absorbance readings (MTS) or live cell counts.
    (Only for Reference)
Animal Research:[2]
+ Expand
  • Animal Models: Female nude mice and male SCID mice with BT474c, U87MG, KPL-4, HCC-1187 xenografts.
  • Formulation: In 10% DMSO 25% w/v Kleptose HPB
  • Dosages: 130 mg/Kg - 300 mg/Kg
  • Administration: p.o.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 86 mg/mL (200.5 mM)
Water Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 428.92
Formula

C21H25ClN6O2

CAS No. 1143532-39-1
Storage powder
Synonyms N/A

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02576444 Recruiting Cancer Joseph Paul Eder|Dana-Farber Cancer Institute|Vanderbilt-Ingram Cancer Center|Yale University November 2015 Phase 2
NCT02465060 Recruiting Advanced Malignant Neoplasm|Lymphoma|Recurrent Plasma Cell Myeloma|Recurrent Solid Neoplasm|Refractory Malignant Neoplasm|Refractory Plasma Cell Myeloma National Cancer Institute (NCI) August 2015 Phase 2
NCT02664935 Recruiting Non-Small Cell Lung Cancer|Carcinoma, Squamous Cell|Adenocarcinoma University of Birmingham|Cancer Research UK|AstraZeneca|Pfizer|Experimental Cancer Medicine Centre Network March 2015 Phase 2
NCT02451956 Recruiting Advanced Gastric Cancer Samsung Medical Center January 2015 Phase 2
NCT02525068 Recruiting Adenocarcinoma of the Prostate Institute of Cancer Research, United Kingdom|Royal Marsden NHS Foundation Trust December 2014 Phase 2
NCT02208375 Recruiting Breast Cancer|Malignant Female Reproductive System Neoplasm M.D. Anderson Cancer Center|AstraZeneca|National Cancer Institute (NCI) November 2014 Phase 1|Phase 2

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID