Akti-1/2

Catalog No.S7776 Synonyms: Akt Inhibitor VIII

Akti-1/2 Chemical Structure

Molecular Weight(MW): 551.64

Akti-1/2 is a highly selective Akt1/Akt2 inhibitor with IC50 of 58 nM/210 nM, respectively, about 36-fold selectivity for Akt1 over Akt3.

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  • AKTi-1/2 inhibits human HCC cells in vitro. Human HCC HepG2 cells (A–F), Huh-7 cells (G), primary human HCC cells (“Pri HCC”, G) or the primary liver cells (“Pri liver cells”, G) were treated with/out applied concentrations of AKTi-1/2 for indicated time; Cell survival (A, B and G), proliferation (C and D) and apoptosis (E and F) were tested by the listed assays. Data were shown as the mean (n = 5) with the standard deviation (SD). Experiments in this figure were repeated three times, with similar results were obtained. *P < 0.05 vs. “C” (untreated control) group.

    Biochem Biophys Res Commun, 2016, 480(3):334-340. Akti-1/2 purchased from Selleck.

    Autophagy inhibitors sensitize AKTi-1/2-induced cytotoxicity against HCC cells. HepG2 cells were treated with/out AKTi-1/2 (5/10 μM) for indicated time; Listed proteins were tested by Western blot assay (A); The percentage of LC3B-II GFP puncta positive cells ("autophagic cells") was calculated (B). HepG2 cells, pretreated with 3-methyladenine (“3 MA”, 10 mM), ammonium chloride (“NH4Cl”, 1 mM) or bafilomycin A1 (“BafA1”, 1 μM) for 1 h, were treated with AKTi-1/2 (10 μM) for applied time; Cell survival (CCK-8 assay, C) were tested. The IC50 was also determined (D).

    Biochem Biophys Res Commun, 2016, 480(3):334-340.. Akti-1/2 purchased from Selleck.

Purity & Quality Control

Choose Selective Akt Inhibitors

Biological Activity

Description Akti-1/2 is a highly selective Akt1/Akt2 inhibitor with IC50 of 58 nM/210 nM, respectively, about 36-fold selectivity for Akt1 over Akt3.
Targets
Akt1 [1]
(Cell-free assay)
Akt2 [1]
(Cell-free assay)
Akt3 [1]
(Cell-free assay)
58 nM 210 nM 2119 nM
In vitro

In a cell-based IPKA (C33A) assay, Akti-1/2 inhibits Akt1 and Akt2 with IC50 of 305 nM and 2086 nM, respectively. In HT29, MCF7, and A2780 cells, Akti-1/2 induces cell apoptosis by dramatically increasing caspase-3 activity. [1] In liver cells, Akti-1/2 blocks insulin regulation of PEPCK, G6Pase expression, and FOXO1 activity. [2] Akti-1/2 also strongly potentiates PAR-1-mediated platelet aggregation by blocking PKB. [3] In HCC827, NCI-H522, NCI-1651, and PC-9 cells, Akti-1/2 inhibits cell growth with IC50 of 4.7 μM, 7.25 μM, and 9.5 μM, when in combination with gefitinib, Akti-1/2 causes enhanced inhibition of cell growth and apoptosis. [4]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
MDA-MB-468 cells MVjDfZRwfG:6aXPpeJkh[XO|YYm= MYmxNEDPxE1? M4PMb2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG1FSS2PQj20Olgh[2WubIOgbY4heHKnc3XuZ4Uhd2ZiMUCgeW0h[2iub4LvdZVqdmViYomgV3JDKGG|c3H5MEBIUTVyPUKuOlYh|ryP NHnrV4wyQDZ7MUi5OC=>
MDA-MB-231 cells NHrSdIlEgXSxdH;4bYNqfHliYYPzZZk> NH;jVmQyOCEQvF2= NH[yT2FEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBOTEFvTVKtNlMyKGOnbHzzJIlvKHC{ZYPlcoNmKG:oIEGwJJVOKGOqbH;yc5F2cW6nIHL5JHNTSiCjc4PhfUwhT0l3ME20MlU2KM7:TR?= M1\WXlE5PjlzOEm0
MCF7 cells NHH3d|REgXSxdH;4bYNqfHliYYPzZZk> MnPaNVAh|ryP NXHUUGM6S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hVUOINzDj[YxteyCrbjDwdoV{\W6lZTDv[kAyOCC3TTDjbIxwem:zdXnu[UBjgSCVUlKgZZN{[XluIFfJOVA:OC52MTFOwG0> NVvUOIRnOTh4OUG4PVQ>
184B5 cells NVj3WJpXS3m2b4TvfIlkcXS7IHHzd4F6 MkfnNlAh|ryP NWnNV3gyS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hOTh2QkWgZ4VtdHNiYYSgNlAhfU1iY3jsc5JweXWrbnWgZpkhW1KEIHHzd4F6NCCJSUWwQVI2Njd4IN88US=> M{TEbFE5PjlzOEm0
NCI-H1563 cell NXTJWHpbT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MW\Jcohq[mm2aX;uJI9nKGi3bXHuJG5EUS2KMUW2N{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVAvPTR{NE[g{txO M{\JPHNCVkeHUh?=
NCI-H1618 cel M2rxXGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MnPBTY5pcWKrdHnvckBw\iCqdX3hckBPS0lvSEG2NVgh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0zOS57OUiyJO69VQ>? NUnuOGp5W0GQR1XS
NCI-H1623 cell NX62fGVKT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MmOxTY5pcWKrdHnvckBw\iCqdX3hckBPS0lvSEG2NlMh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yPS5yNUm2JO69VQ>? M4npdXNCVkeHUh?=
NCI-H1648 cell M3THZmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NW\FXldLUW6qaXLpeIlwdiCxZjDoeY1idiCQQ1mtTFE3PDhiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD13Lke1OVEh|ryP MYjTRW5ITVJ?
NCI-H1650 cell MoXnS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M3TRVGlvcGmkaYTpc44hd2ZiaIXtZY4hVkOLLVixOlUxKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OTFwNUGzOEDPxE1? NHL3WVJUSU6JRWK=
NCI-H1651 cell Mlq3S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NYHjfo1NUW6qaXLpeIlwdiCxZjDoeY1idiCQQ1mtTFE3PTFiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1zNj60N|M5KM7:TR?= M3HxbHNCVkeHUh?=
NCI-H1703 cell Mli1S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MWTJcohq[mm2aX;uJI9nKGi3bXHuJG5EUS2KMUewN{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVE2NjV5NzFOwG0> M4\obXNCVkeHUh?=
NCI-H1734 cell Mnn3S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M3i2TGlvcGmkaYTpc44hd2ZiaIXtZY4hVkOLLVixO|M1KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OTBwN{e4PEDPxE1? M{[0b3NCVkeHUh?=
NCI-H1755 cell MlrHS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NGC5PGxKdmirYnn0bY9vKG:oIHj1cYFvKE6FST3INVc2PSClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTFwMEW1N|Eh|ryP M4LIS3NCVkeHUh?=
NCI-H1770 cell MoDYS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NX7VXo5sUW6qaXLpeIlwdiCxZjDoeY1idiCQQ1mtTFE4PzBiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1|ND6xO|k{KM7:TR?= MlXPV2FPT0WU
NCI-H1792 cell MmezS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NGjXSXRKdmirYnn0bY9vKG:oIHj1cYFvKE6FST3INVc6OiClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTJ7LkizO|kh|ryP M4jBdXNCVkeHUh?=
NCI-H1963 cell MoHkS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NH7NVI1KdmirYnn0bY9vKG:oIHj1cYFvKE6FST3INVk3OyClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTF7Lke0PVQh|ryP Mn7GV2FPT0WU
NCI-H1993 cell MnXRS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NHL6VI9KdmirYnn0bY9vKG:oIHj1cYFvKE6FST3INVk6OyClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTJ{Lk[xOUDPxE1? M1nVUnNCVkeHUh?=
NCI-H2009 cell MX;Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MnjxTY5pcWKrdHnvckBw\iCqdX3hckBPS0lvSEKwNFkh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF04NjN7MEG5JO69VQ>? M4XBW3NCVkeHUh?=
NCI-H2030 cell M3vX[mdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NFzIdWNKdmirYnn0bY9vKG:oIHj1cYFvKE6FST3INlA{OCClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTFwOUS0PFMh|ryP MnzuV2FPT0WU
NCI-H2122 cell NGXJTXJIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NVXzfGUzUW6qaXLpeIlwdiCxZjDoeY1idiCQQ1mtTFIyOjJiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1zMD6xN|g2KM7:TR?= NUTWT|lmW0GQR1XS
NCI-H2126 cell MXHHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MUXJcohq[mm2aX;uJI9nKGi3bXHuJG5EUS2KMkGyOkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEzNjN|N{Gg{txO MV3TRW5ITVJ?
NCI-H2170 cell M{jaW2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MoGzTY5pcWKrdHnvckBw\iCqdX3hckBPS0lvSEKxO|Ah[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yQC5zMEK4JO69VQ>? MnnXV2FPT0WU
NCI-H2196 cell MlPlS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MXnJcohq[mm2aX;uJI9nKGi3bXHuJG5EUS2KMkG5OkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVI1NjhyMEOg{txO NE[yTGtUSU6JRWK=
NCI-H2228 cell NYSy[mZPT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NI\XWoJKdmirYnn0bY9vKG:oIHj1cYFvKE6FST3INlIzQCClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTJwMki2NFQh|ryP MYPTRW5ITVJ?
NCI-H2342 cell NHT0PYJIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MWHJcohq[mm2aX;uJI9nKGi3bXHuJG5EUS2KMkO0NkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVAvQTN5N{mg{txO M1vpO3NCVkeHUh?=
NCI-H2347 cell NX\1Z3lPT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MY\Jcohq[mm2aX;uJI9nKGi3bXHuJG5EUS2KMkO0O{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVE3NjF3OEGg{txO NUjOW3FKW0GQR1XS
NCI-H2405 cell Ml3jS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M{XMOGlvcGmkaYTpc44hd2ZiaIXtZY4hVkOLLViyOFA2KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OTBwNEKxNkDPxE1? NVTY[G9LW0GQR1XS
NCI-H2452 cell MoPGS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MXXJcohq[mm2aX;uJI9nKGi3bXHuJG5EUS2KMkS1NkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVI3NjZ3OUSg{txO MWfTRW5ITVJ?
NCI-H292 cell MVHHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NHWxe5BKdmirYnn0bY9vKG:oIHj1cYFvKE6FST3INlkzKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:Pi5yNEizO{DPxE1? NIfXV4xUSU6JRWK=
NCI-H345 cell NFrhdlZIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NH7EeHFKdmirYnn0bY9vKG:oIHj1cYFvKE6FST3IN|Q2KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OTZwMkewOkDPxE1? MUfTRW5ITVJ?
NCI-H358 cell NYSwblJ7T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NXTkeJhQUW6qaXLpeIlwdiCxZjDoeY1idiCQQ1mtTFM2QCClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTF7LkeyN|Mh|ryP M2TzW3NCVkeHUh?=
NCI-H460 cell M3n3R2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NV;NXGRDUW6qaXLpeIlwdiCxZjDoeY1idiCQQ1mtTFQ3OCClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTRwNkK5PVMh|ryP MnvpV2FPT0WU
NCI-H520 cell NXLESWRqT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NXzsVW55UW6qaXLpeIlwdiCxZjDoeY1idiCQQ1mtTFUzOCClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTFwMUOzNFMh|ryP MoXlV2FPT0WU
NCI-H522 cell MUDHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M2\iOWlvcGmkaYTpc44hd2ZiaIXtZY4hVkOLLVi1NlIh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yOS5yOEe0JO69VQ>? MVXTRW5ITVJ?
NCI-H526 cell MkXlS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M1PESmlvcGmkaYTpc44hd2ZiaIXtZY4hVkOLLVi1NlYh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0zOi56OEez{txO M4\IZ3NCVkeHUh?=
NCI-H596 MXvHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NHm1[HlKdmirYnn0bY9vKG:oIHj1cYFvKE6FST3IOVk3KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OTdwNUewPEDPxE1? MUPTRW5ITVJ?
NCI-H630 cell NUXFbYg5T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M{fsTWlvcGmkaYTpc44hd2ZiaIXtZY4hVkOLLVi2N|Ah[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF02NjVzMEW1JO69VQ>? MX7TRW5ITVJ?
NCI-H64 cell NEDQN5NIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MWXJcohq[mm2aX;uJI9nKGi3bXHuJG5EUS2KNkSgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xNk42PDNzIN88US=> Mkm4V2FPT0WU
NCI-H650 cell NWnWTFFDT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MV3Jcohq[mm2aX;uJI9nKGi3bXHuJG5EUS2KNkWwJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9O{42QTh5NzFOwG0> MUfTRW5ITVJ?
NCI-H661 cell MU\Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MmX1TY5pcWKrdHnvckBw\iCqdX3hckBPS0lvSE[2NUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVUvPDJ|Mk[g{txO NF7HTWpUSU6JRWK=
NCI-H747 cell NEHQVFVIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MUDJcohq[mm2aX;uJI9nKGi3bXHuJG5EUS2KN{S3JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9O{43Ojd7OTFOwG0> MnzhV2FPT0WU
NCI-H838 cell M2XiT2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NGrUdmRKdmirYnn0bY9vKG:oIHj1cYFvKE6FST3IPFM5KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OzFwNEGxPEDPxE1? MXrTRW5ITVJ?
NCI-N87 cell NXi3RVlnT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MWrJcohq[mm2aX;uJI9nKGi3bXHuJG5EUS2QOEegZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yPU4{ODR{IN88US=> M2DVdHNCVkeHUh?=
NH-12 cell M2OwXWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M1vYbWlvcGmkaYTpc44hd2ZiaIXtZY4hVkhvMUKgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2wMlYxQDZ2IN88US=> NYruenFLW0GQR1XS
NKM-1 cell M3TDUmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M1[3XGlvcGmkaYTpc44hd2ZiaIXtZY4hVkuPLUGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yMlc2QTJ|IN88US=> M3HwVnNCVkeHUh?=
NMC-G1 cell Ml\BS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MWjJcohq[mm2aX;uJI9nKGi3bXHuJG5OSy2JMTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUSyMlY3QTNizszN MYTTRW5ITVJ?
NOS-1 cell M3H1UWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 Mlq1TY5pcWKrdHnvckBw\iCqdX3hckBPV1NvMTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGuN|Y6PTNizszN MoXDV2FPT0WU
NUGC-3 cell MV3Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MknPTY5pcWKrdHnvckBw\iCqdX3hckBPXUeFLUOgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xOk42QTB4IN88US=> MWrTRW5ITVJ?
NY cell MlGyS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MoTCTY5pcWKrdHnvckBw\iCqdX3hckBPYSClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTNzLkG4OlQh|ryP M3q1fHNCVkeHUh?=
OAW-42 cell MVHHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NGjHclBKdmirYnn0bY9vKG:oIHj1cYFvKE:DVz20NkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVcvOzF3NkWg{txO Ml34V2FPT0WU
OCI-AML2 cell NFf3emNIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M2PKcmlvcGmkaYTpc44hd2ZiaIXtZY4hV0OLLVHNUFIh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0{Oy5{NUOxJO69VQ>? NWn3fZd5W0GQR1XS
OCUB-M cell M3vvcWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MX7Jcohq[mm2aX;uJI9nKGi3bXHuJG9EXUJvTTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUeuO|IyPTJizszN NYq3b2V4W0GQR1XS
OE19 cell MXrHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NX7ne|hXUW6qaXLpeIlwdiCxZjDoeY1idiCRRUG5JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9O{44PjZ6NDFOwG0> M4f2fHNCVkeHUh?=
OE33 cell MkfiS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NWOxOJVwUW6qaXLpeIlwdiCxZjDoeY1idiCRRUOzJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU45QDl{NjFOwG0> MmjFV2FPT0WU
OMC-1 cell MnXwS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M2rT[2lvcGmkaYTpc44hd2ZiaIXtZY4hV02FLUGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME25MlI2ODl6IN88US=> MmKzV2FPT0WU
OS-RC-2 cell MV7Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M2XPUmlvcGmkaYTpc44hd2ZiaIXtZY4hV1NvUlOtNkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVgvPTJ|MEeg{txO M37TSnNCVkeHUh?=
OVCAR-3 cell NFTYcHVIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MVTJcohq[mm2aX;uJI9nKGi3bXHuJG9XS0GULUOgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlg1PDF3IN88US=> NWHvTJo{W0GQR1XS
OVCAR-4 cell NXrsU3FzT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MonCTY5pcWKrdHnvckBw\iCqdX3hckBQXkODUj20JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9N|AvPDZ4IN88US=> MojRV2FPT0WU
P12-ICHIKAWA cell NUi2V|ZlT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NUTjS29[UW6qaXLpeIlwdiCxZjDoeY1idiCSMUKtTWNJUUuDV1GgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xOE44Pjh|IN88US=> NE\FbZBUSU6JRWK=
P30-OHK cell NVLZRmZuT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MUHJcohq[mm2aX;uJI9nKGi3bXHuJHA{OC2RSFugZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME20MlU{PiEQvF2= MlywV2FPT0WU
PA-1 cell M1vXVWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MlfDTY5pcWKrdHnvckBw\iCqdX3hckBRSS1zIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;OT6wO|YyPSEQvF2= NGPzNFBUSU6JRWK=
PANC-03-27 cell MmHDS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MYnJcohq[mm2aX;uJI9nKGi3bXHuJHBCVkNvMEOtNlch[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF05NjdzMEiyJO69VQ>? MWPTRW5ITVJ?
PANC-10-05 cell NHLVbnFIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MljiTY5pcWKrdHnvckBw\iCqdX3hckBRSU6FLUGwMVA2KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OTRwOUm1PUDPxE1? MnzmV2FPT0WU
PC-3 cell MX;Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NF;sT|VKdmirYnn0bY9vKG:oIHj1cYFvKFCFLUOgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xNE42OTN3IN88US=> M4WzS3NCVkeHUh?=
PF-382 cell MXzHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MnjHTY5pcWKrdHnvckBw\iCqdX3hckBRTi1|OEKgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xNU43QDJ6IN88US=> NUDMN5VMW0GQR1XS
RCC10RGB cell Mlj0S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MkCxTY5pcWKrdHnvckBw\iCqdX3hckBTS0NzMGLHRkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVgvPjV4NzFOwG0> NWfNOZBTW0GQR1XS
RD cell NFzwXFZIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MUTJcohq[mm2aX;uJI9nKGi3bXHuJHJFKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OjBwNkCzOkDPxE1? MmDSV2FPT0WU
REH cell NGLucVBIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M2\BO2lvcGmkaYTpc44hd2ZiaIXtZY4hWkWKIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MUGuOFg5OyEQvF2= M37IbHNCVkeHUh?=
RERF-LC-MS cell NX62[FBxT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MkjpTY5pcWKrdHnvckBw\iCqdX3hckBTTVKILVzDMW1UKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OjZwMUO0O{DPxE1? Mo\LV2FPT0WU
RKO cell M3\C[Gdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M37ufmlvcGmkaYTpc44hd2ZiaIXtZY4hWkuRIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MUmuOFQ{QSEQvF2= M2DkUnNCVkeHUh?=
RO82-W-1 cell M2i4Zmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MmDGTY5pcWKrdHnvckBw\iCqdX3hckBTVzh{LWetNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVQ4NjJ5OEOg{txO NHu1UlBUSU6JRWK=
RPMI-2650 cell NHTRbpJIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NWr6dmFHUW6qaXLpeIlwdiCxZjDoeY1idiCUUF3JMVI3PTBiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD13Lke3PVQ4KM7:TR?= MmezV2FPT0WU
RPMI-8402 cell Mn65S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MXTJcohq[mm2aX;uJI9nKGi3bXHuJHJRVUlvOESwNkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVE3NjN2MzFOwG0> NVvo[lUxW0GQR1XS
RS4-11 cell NInoRlRIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NXrIeVlEUW6qaXLpeIlwdiCxZjDoeY1idiCUU{StNVEh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF03NjZ6NkS1JO69VQ>? M3jKVnNCVkeHUh?=
RT-112 cell M2XsRWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MVrJcohq[mm2aX;uJI9nKGi3bXHuJHJVNTFzMjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPU[uO|E6PTJizszN MnjUV2FPT0WU
RVH-421 cell NYLofpJlT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M16yTmlvcGmkaYTpc44hd2ZiaIXtZY4hWl[KLUSyNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVMzNjN4ME[g{txO MmLHV2FPT0WU
RXF393 cell M3TRSGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M{e2UmlvcGmkaYTpc44hd2ZiaIXtZY4hWliIM{mzJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NlAvPTh4MzFOwG0> M1vscHNCVkeHUh?=
SBC-5 cell MnvSS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NEf5VWpKdmirYnn0bY9vKG:oIHj1cYFvKFOEQz21JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NlAvQDN{NTFOwG0> M1LvW3NCVkeHUh?=
SCC-25 cell MnmzS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MUHJcohq[mm2aX;uJI9nKGi3bXHuJHNESy1{NTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUG1MlgyPzlizszN M{WzS3NCVkeHUh?=
SCC-4 cell Ml3iS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NIexNVNKdmirYnn0bY9vKG:oIHj1cYFvKFOFQz20JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9PU42QTJ6MzFOwG0> NWfDfYZyW0GQR1XS
SCC-9 cell M2LmTGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 Moq3TY5pcWKrdHnvckBw\iCqdX3hckBUS0NvOTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUOuNFg2OzZizszN M2PB[3NCVkeHUh?=
SF126 cell MUjHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M1H3UmlvcGmkaYTpc44hd2ZiaIXtZY4hW0ZzMk[gZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xNE43PzR4IN88US=> Mn;3V2FPT0WU
SF268 cell MljUS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MULJcohq[mm2aX;uJI9nKGi3bXHuJHNHOjZ6IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MUWuNVM5PyEQvF2= NGO2PWFUSU6JRWK=
SF295 cell NIjNdXVIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MWPJcohq[mm2aX;uJI9nKGi3bXHuJHNHOjl3IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MUOuOlE5OyEQvF2= NYHYR3V3W0GQR1XS
SIG-M5 cell MWjHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NIf4XItKdmirYnn0bY9vKG:oIHj1cYFvKFOLRz3NOUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEzNjZ4MESg{txO NYnhT29sW0GQR1XS
SJSA-1 cell M2ewSmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MlXNTY5pcWKrdHnvckBw\iCqdX3hckBUUlODLUGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2zOk46ODd{IN88US=> MULTRW5ITVJ?
SK-CO-1 cell MlTES5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M2fmc2lvcGmkaYTpc44hd2ZiaIXtZY4hW0tvQ1:tNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVExNjZ|OUSg{txO NXP4N|NNW0GQR1XS
SK-LMS-1 cell MXHHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M1zodGlvcGmkaYTpc44hd2ZiaIXtZY4hW0tvTF3TMVEh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF05Njd4NEWyJO69VQ>? MUHTRW5ITVJ?
SK-LU-1 cell MoO1S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M{X6fmlvcGmkaYTpc44hd2ZiaIXtZY4hW0tvTGWtNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVQzNjB2MzFOwG0> MU\TRW5ITVJ?
SK-MEL-24 cell NUPLXm1DT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NIn3OJhKdmirYnn0bY9vKG:oIHj1cYFvKFONLV3FUE0zPCClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTF|LkG2O|Uh|ryP MUHTRW5ITVJ?
SK-MEL-3 cell NWrSSG5CT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= Mk[1TY5pcWKrdHnvckBw\iCqdX3hckBUUy2PRVytN{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIyNjR4OU[g{txO NEn6O5BUSU6JRWK=
SK-MES-1 cell Moq1S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M2fwVmlvcGmkaYTpc44hd2ZiaIXtZY4hW0tvTVXTMVEh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0zNjFyMEm2JO69VQ>? M3HUdHNCVkeHUh?=
human SN12C cell MkfRS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NITv[JJKdmirYnn0bY9vKG:oIHj1cYFvKFOQMULDJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NVcvOTl4NzFOwG0> NF\MZnFUSU6JRWK=
SNB75 cell NWW3[opOT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NHexTldKdmirYnn0bY9vKG:oIHj1cYFvKFOQQke1JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9O{45Ojl5IN88US=> NGe4fGtUSU6JRWK=
SNU-387 cell NYT3eZpyT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MoLXTY5pcWKrdHnvckBw\iCqdX3hckBUVlVvM{i3JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9OE4yQTV2NDFOwG0> Mo[2V2FPT0WU
SNU-423 cell MXPHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MXzJcohq[mm2aX;uJI9nKGi3bXHuJHNPXS12MkOgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME21Mlk1QTN|IN88US=> MVTTRW5ITVJ?
SNU-C1 cell M3rvZ2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NEHSOXVKdmirYnn0bY9vKG:oIHj1cYFvKFOQVT3DNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIvODB7NEig{txO MUDTRW5ITVJ?
SNU-C2B cell MmDHS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NW[5emVNUW6qaXLpeIlwdiCxZjDoeY1idiCVTmWtR|JDKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OjJwMk[3N{DPxE1? MVjTRW5ITVJ?
SR cell MYLHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MUjJcohq[mm2aX;uJI9nKGi3bXHuJHNTKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OTNwMEe0OkDPxE1? MXrTRW5ITVJ?
SU-DHL-1 cell Mm\YS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M133R2lvcGmkaYTpc44hd2ZiaIXtZY4hW1VvRFjMMVEh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF03NjhzNUSzJO69VQ>? M2PLdnNCVkeHUh?=
SW1710 cell NHHrUGVIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NHTWe2lKdmirYnn0bY9vKG:oIHj1cYFvKFOZMUexNEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEvOzh6OUKg{txO NX7SVZR1W0GQR1XS
SW780 cell MYnHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M3ra[2lvcGmkaYTpc44hd2ZiaIXtZY4hW1d5OECgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME20Mlg6OzV6IN88US=> NFjhRnJUSU6JRWK=
SW872 cell M4jSRWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NX\TZ4kzUW6qaXLpeIlwdiCxZjDoeY1idiCVV{i3NkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVE1NjF2M{Wg{txO Mn\5V2FPT0WU
SW954 cell NHfobIpIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M{LwUmlvcGmkaYTpc44hd2ZiaIXtZY4hW1d7NUSgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME21Mlg2Pzh|IN88US=> M162V3NCVkeHUh?=
T47D cell NXf0fVY5T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MmTrTY5pcWKrdHnvckBw\iCqdX3hckBVPDeGIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MD61NVYzKM7:TR?= MWnTRW5ITVJ?
22RV1 cell M{fmVmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NWP3RnN3UW6qaXLpeIlwdiCxZjDoeY1idiB{MmLWNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVYvPjF2MkSg{txO NVnheIprW0GQR1XS
23132-87 cell Mn\yS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NUnaNoNqUW6qaXLpeIlwdiCxZjDoeY1idiB{M{GzNk05PyClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTBwN{W5N|gh|ryP MkLZV2FPT0WU
639-V cell NVrjdWJHT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M3i3d2lvcGmkaYTpc44hd2ZiaIXtZY4hPjN7LW[gZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME21Mlg4PzNizszN NYHqfllVW0GQR1XS
697 cell MnriS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NInjV2NKdmirYnn0bY9vKG:oIHj1cYFvKDZ7NzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUeuNVc4PDZizszN MWXTRW5ITVJ?
769-P cell NYG5UWtvT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MWrJcohq[mm2aX;uJI9nKGi3bXHuJFc3QS2SIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MT6xNFQ5OyEQvF2= NITv[XdUSU6JRWK=
8-MG-BA cell MYPHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NHv0b4NKdmirYnn0bY9vKG:oIHj1cYFvKDhvTVetRmEh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF05NjZ|NECxJO69VQ>? M4PkbnNCVkeHUh?=
A4-Fuk cell NGPqcVlIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NHHiZmhKdmirYnn0bY9vKG:oIHj1cYFvKEF2LV\1b{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEvQDV6MzFOwG0> NHnw[I1USU6JRWK=
A427 cell Ml[5S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M1u5ZWlvcGmkaYTpc44hd2ZiaIXtZY4hSTR{NzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUOuNFc3QTNizszN NFrOWVVUSU6JRWK=
A498 cell MoPVS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MXnJcohq[mm2aX;uJI9nKGi3bXHuJGE1QThiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1zLkC4NVM1KM7:TR?= M1q2OHNCVkeHUh?=
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... Click to View More Cell Line Experimental Data

In vivo In mice, Akti-1/2 (50 mg/kg, i.p.) inhibits basal and IGF-stimulated Akt1 and Akt2 phosphorylation in lung. [1]

Protocol

Kinase Assay:[2]
+ Expand

Kinase screen:

Briefly, all assays (25.5 μl at 21°C for 30 min) are performed using a Biomek 2000 Laboratory Automation Workstation in a 96-well format. Reactions contains 5–20 mU purified kinase along with substrate peptide or protein and are initiated by the addition of 10 mM MgAcetate and 5, 20, or 50 μM ATP ([γ-33P]-ATP, 800 cpm/pmol).
Cell Research:[4 ]
+ Expand
  • Cell lines: HCC827, NCI-H522, NCI-1651, and PC-9 cells
  • Concentrations: ~10 μM
  • Incubation Time: 96 h
  • Method: The cell growth inhibitory effect of AKTi-1/2 is studied using the 96 h sulforhodamine B assay (SRB). Drug concentrations that inhibited 50% of cell growth (IC50) are calculated for each compound in GraphPad Prism 6.0 using non-linear regression analysis and sigmoidal dose–response (variable slope) equation.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 22 mg/mL (39.88 mM)
Water Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 551.64
Formula

C34H29N7O

CAS No. 612847-09-3
Storage powder
in solvent
Synonyms Akt Inhibitor VIII

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Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

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