Akti-1/2

Catalog No.S7776 Synonyms: Akt Inhibitor VIII

Akti-1/2 Chemical Structure

Molecular Weight(MW): 551.64

Akti-1/2 is a highly selective Akt1/Akt2 inhibitor with IC50 of 58 nM/210 nM, respectively, about 36-fold selectivity for Akt1 over Akt3.

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  • AKTi-1/2 inhibits human HCC cells in vitro. Human HCC HepG2 cells (A–F), Huh-7 cells (G), primary human HCC cells (“Pri HCC”, G) or the primary liver cells (“Pri liver cells”, G) were treated with/out applied concentrations of AKTi-1/2 for indicated time; Cell survival (A, B and G), proliferation (C and D) and apoptosis (E and F) were tested by the listed assays. Data were shown as the mean (n = 5) with the standard deviation (SD). Experiments in this figure were repeated three times, with similar results were obtained. *P < 0.05 vs. “C” (untreated control) group.

    Biochem Biophys Res Commun, 2016, 480(3):334-340. Akti-1/2 purchased from Selleck.

    Autophagy inhibitors sensitize AKTi-1/2-induced cytotoxicity against HCC cells. HepG2 cells were treated with/out AKTi-1/2 (5/10 μM) for indicated time; Listed proteins were tested by Western blot assay (A); The percentage of LC3B-II GFP puncta positive cells ("autophagic cells") was calculated (B). HepG2 cells, pretreated with 3-methyladenine (“3 MA”, 10 mM), ammonium chloride (“NH4Cl”, 1 mM) or bafilomycin A1 (“BafA1”, 1 μM) for 1 h, were treated with AKTi-1/2 (10 μM) for applied time; Cell survival (CCK-8 assay, C) were tested. The IC50 was also determined (D).

    Biochem Biophys Res Commun, 2016, 480(3):334-340.. Akti-1/2 purchased from Selleck.

Purity & Quality Control

Choose Selective Akt Inhibitors

Biological Activity

Description Akti-1/2 is a highly selective Akt1/Akt2 inhibitor with IC50 of 58 nM/210 nM, respectively, about 36-fold selectivity for Akt1 over Akt3.
Targets
Akt1 [1]
(Cell-free assay)
Akt2 [1]
(Cell-free assay)
Akt3 [1]
(Cell-free assay)
58 nM 210 nM 2119 nM
In vitro

In a cell-based IPKA (C33A) assay, Akti-1/2 inhibits Akt1 and Akt2 with IC50 of 305 nM and 2086 nM, respectively. In HT29, MCF7, and A2780 cells, Akti-1/2 induces cell apoptosis by dramatically increasing caspase-3 activity. [1] In liver cells, Akti-1/2 blocks insulin regulation of PEPCK, G6Pase expression, and FOXO1 activity. [2] Akti-1/2 also strongly potentiates PAR-1-mediated platelet aggregation by blocking PKB. [3] In HCC827, NCI-H522, NCI-1651, and PC-9 cells, Akti-1/2 inhibits cell growth with IC50 of 4.7 μM, 7.25 μM, and 9.5 μM, when in combination with gefitinib, Akti-1/2 causes enhanced inhibition of cell growth and apoptosis. [4]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
MDA-MB-468 cells MknsR5l1d3SxeHnjbZR6KGG|c3H5 NIn5d2EyOCEQvF2= NVG1c2MyS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hVUSDLV3CMVQ3QCClZXzsd{BqdiCycnXz[Y5k\SCxZjCxNEB2VSClaHzvdo9yfWmwZTDifUBUWkJiYYPzZZktKEeLNUC9Nk43PiEQvF2= M16wOlE5PjlzOEm0
MDA-MB-231 cells Ml3PR5l1d3SxeHnjbZR6KGG|c3H5 NHzUVIcyOCEQvF2= NHrsUVREgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBOTEFvTVKtNlMyKGOnbHzzJIlvKHC{ZYPlcoNmKG:oIEGwJJVOKGOqbH;yc5F2cW6nIHL5JHNTSiCjc4PhfUwhT0l3ME20MlU2KM7:TR?= MXuxPFY6OTh7NB?=
MCF7 cells MljtR5l1d3SxeHnjbZR6KGG|c3H5 MkG5NVAh|ryP MUjDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDNR2Y4KGOnbHzzJIlvKHC{ZYPlcoNmKG:oIEGwJJVOKGOqbH;yc5F2cW6nIHL5JHNTSiCjc4PhfUwhT0l3ME2wMlQyKM7:TR?= NFL1SlgyQDZ7MUi5OC=>
184B5 cells NF;NemtEgXSxdH;4bYNqfHliYYPzZZk> M{ntW|IxKM7:TR?= NEG0VGFEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckAyQDSENTDj[YxteyCjdDCyNEB2VSClaHzvdo9yfWmwZTDifUBUWkJiYYPzZZktKEeLNUC9NlUvPzZizszN MmC5NVg3QTF6OUS=
NCI-H1563 cell MX;Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NYrHdohwUW6qaXLpeIlwdiCxZjDoeY1idiCQQ1mtTFE2PjNiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1yLkW0NlQ3KM7:TR?= MXTTRW5ITVJ?
NCI-H1618 cel NI\SXmxIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MXTJcohq[mm2aX;uJI9nKGi3bXHuJG5EUS2KMU[xPEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIyNjl7OEKg{txO M2LlPHNCVkeHUh?=
NCI-H1623 cell NX3qSYJbT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M{fWTmlvcGmkaYTpc44hd2ZiaIXtZY4hVkOLLVixOlI{KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OTVwMEW5OkDPxE1? NYX0WWJuW0GQR1XS
NCI-H1648 cell NFLPSJBIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M17BbWlvcGmkaYTpc44hd2ZiaIXtZY4hVkOLLVixOlQ5KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:PS55NUWxJO69VQ>? MXXTRW5ITVJ?
NCI-H1650 cell MUXHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NFfjclBKdmirYnn0bY9vKG:oIHj1cYFvKE6FST3INVY2OCClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTFzLkWxN|Qh|ryP NVPTOmpkW0GQR1XS
NCI-H1651 cell MWPHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M1zSW2lvcGmkaYTpc44hd2ZiaIXtZY4hVkOLLVixOlUyKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OTZwNEOzPEDPxE1? M2DI[nNCVkeHUh?=
NCI-H1703 cell NHHrPFhIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NG\DPW9KdmirYnn0bY9vKG:oIHj1cYFvKE6FST3INVcxOyClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTF3LkW3O{DPxE1? Mn:4V2FPT0WU
NCI-H1734 cell Mme5S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NXXme45{UW6qaXLpeIlwdiCxZjDoeY1idiCQQ1mtTFE4OzRiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1zMD63O|g5KM7:TR?= M2rpV3NCVkeHUh?=
NCI-H1755 cell NGHkN45Iem:5dHigbY5pcWKrdHnvckBie3OjeR?= NFrKU3VKdmirYnn0bY9vKG:oIHj1cYFvKE6FST3INVc2PSClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTFwMEW1N|Eh|ryP MX\TRW5ITVJ?
NCI-H1770 cell MYXHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MVfJcohq[mm2aX;uJI9nKGi3bXHuJG5EUS2KMUe3NEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVM1NjF5OUOg{txO M4qyPHNCVkeHUh?=
NCI-H1792 cell MXXHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M{LGfGlvcGmkaYTpc44hd2ZiaIXtZY4hVkOLLVixO|kzKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OjlwOEO3PUDPxE1? M1\uc3NCVkeHUh?=
NCI-H1963 cell NETScnNIem:5dHigbY5pcWKrdHnvckBie3OjeR?= Mkf6TY5pcWKrdHnvckBw\iCqdX3hckBPS0lvSEG5OlMh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yQS55NEm0JO69VQ>? MXrTRW5ITVJ?
NCI-H1993 cell Ml\CS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NX[wWGJsUW6qaXLpeIlwdiCxZjDoeY1idiCQQ1mtTFE6QTNiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1{Mj62NVUh|ryP MlywV2FPT0WU
NCI-H2009 cell NFHCTHBIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MlP5TY5pcWKrdHnvckBw\iCqdX3hckBPS0lvSEKwNFkh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF04NjN7MEG5JO69VQ>? NEfQSoRUSU6JRWK=
NCI-H2030 cell M2PYXGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MUHJcohq[mm2aX;uJI9nKGi3bXHuJG5EUS2KMkCzNEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEvQTR2OEOg{txO MXnTRW5ITVJ?
NCI-H2122 cell MonrS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NHfkbphKdmirYnn0bY9vKG:oIHj1cYFvKE6FST3INlEzOiClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTFyLkGzPFUh|ryP MnLmV2FPT0WU
NCI-H2126 cell MoLhS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M1HFNmlvcGmkaYTpc44hd2ZiaIXtZY4hVkOLLViyNVI3KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OTJwM{O3NUDPxE1? MU\TRW5ITVJ?
NCI-H2170 cell MWHHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NGPCWHlKdmirYnn0bY9vKG:oIHj1cYFvKE6FST3INlE4OCClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTF6LkGwNlgh|ryP MkDLV2FPT0WU
NCI-H2196 cell NFrIWFRIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NHnDbnFKdmirYnn0bY9vKG:oIHj1cYFvKE6FST3INlE6PiClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTJ2LkiwNFMh|ryP NW\xVmR4W0GQR1XS
NCI-H2228 cell MlvOS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MXTJcohq[mm2aX;uJI9nKGi3bXHuJG5EUS2KMkKyPEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIvOjh4MESg{txO NH7oRVlUSU6JRWK=
NCI-H2342 cell NVq3T4RUT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NVvwelhYUW6qaXLpeIlwdiCxZjDoeY1idiCQQ1mtTFI{PDJiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1yLkmzO|c6KM7:TR?= NY[0Z4dkW0GQR1XS
NCI-H2347 cell MV7Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M4TIPWlvcGmkaYTpc44hd2ZiaIXtZY4hVkOLLViyN|Q4KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OTZwMUW4NUDPxE1? MUfTRW5ITVJ?
NCI-H2405 cell Mof0S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NGP3bJJKdmirYnn0bY9vKG:oIHj1cYFvKE6FST3INlQxPSClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTFyLkSyNVIh|ryP NIG5RWlUSU6JRWK=
NCI-H2452 cell MnnlS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M1GzXWlvcGmkaYTpc44hd2ZiaIXtZY4hVkOLLViyOFUzKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OjZwNkW5OEDPxE1? MYPTRW5ITVJ?
NCI-H292 cell M37lfmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NY\td|VMUW6qaXLpeIlwdiCxZjDoeY1idiCQQ1mtTFI6OiClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTZwMES4N|ch|ryP NEDCXWRUSU6JRWK=
NCI-H345 cell M3jFR2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MULJcohq[mm2aX;uJI9nKGi3bXHuJG5EUS2KM{S1JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NVYvOjdyNjFOwG0> MWrTRW5ITVJ?
NCI-H358 cell NVLkSlM5T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NX7NRo1jUW6qaXLpeIlwdiCxZjDoeY1idiCQQ1mtTFM2QCClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTF7LkeyN|Mh|ryP MV7TRW5ITVJ?
NCI-H460 cell NV;IcpFHT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NIXj[IZKdmirYnn0bY9vKG:oIHj1cYFvKE6FST3IOFYxKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:PC54Mkm5N{DPxE1? Mn\FV2FPT0WU
NCI-H520 cell MV;Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MkHpTY5pcWKrdHnvckBw\iCqdX3hckBPS0lvSEWyNEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEvOTN|MEOg{txO MXLTRW5ITVJ?
NCI-H522 cell M3nnV2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M1;XdGlvcGmkaYTpc44hd2ZiaIXtZY4hVkOLLVi1NlIh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yOS5yOEe0JO69VQ>? NI\LSYpUSU6JRWK=
NCI-H526 cell MUjHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MWnJcohq[mm2aX;uJI9nKGi3bXHuJG5EUS2KNUK2JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NlIvQDh5M988US=> NGnKfmZUSU6JRWK=
NCI-H596 NH3ITXdIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MV7Jcohq[mm2aX;uJI9nKGi3bXHuJG5EUS2KNUm2JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NVcvPTdyODFOwG0> MWDTRW5ITVJ?
NCI-H630 cell NHHhSldIem:5dHigbY5pcWKrdHnvckBie3OjeR?= Mkf6TY5pcWKrdHnvckBw\iCqdX3hckBPS0lvSE[zNEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVUvPTFyNUWg{txO MYLTRW5ITVJ?
NCI-H64 cell NYDXbo5UT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NUPYfpk4UW6qaXLpeIlwdiCxZjDoeY1idiCQQ1mtTFY1KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OTJwNUSzNUDPxE1? NIW0[|RUSU6JRWK=
NCI-H650 cell NY[zcY5xT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MmLWTY5pcWKrdHnvckBw\iCqdX3hckBPS0lvSE[1NEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVcvPTl6N{eg{txO MlXMV2FPT0WU
NCI-H661 cell NF\XOnBIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M3:0TWlvcGmkaYTpc44hd2ZiaIXtZY4hVkOLLVi2OlEh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF02NjR{M{K2JO69VQ>? Mm\FV2FPT0WU
NCI-H747 cell MUnHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MnTZTY5pcWKrdHnvckBw\iCqdX3hckBPS0lvSEe0O{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVcvPjJ5OUmg{txO NYK4N4R5W0GQR1XS
NCI-H838 cell M3HCSWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 Mk\tTY5pcWKrdHnvckBw\iCqdX3hckBPS0lvSEizPEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVMyNjRzMUig{txO M4PCTXNCVkeHUh?=
NCI-N87 cell MnLYS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MnLUTY5pcWKrdHnvckBw\iCqdX3hckBPS0lvTki3JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NlkvOzB2MjFOwG0> MVzTRW5ITVJ?
NH-12 cell M{TmZmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M4PZ[GlvcGmkaYTpc44hd2ZiaIXtZY4hVkhvMUKgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2wMlYxQDZ2IN88US=> Mkj6V2FPT0WU
NKM-1 cell M4G5U2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MmOzTY5pcWKrdHnvckBw\iCqdX3hckBPU01vMTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUKuO|U6OjNizszN NHjnd25USU6JRWK=
NMC-G1 cell M2fVeWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NYCzOIlOUW6qaXLpeIlwdiCxZjDoeY1idiCQTVOtS|Eh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF01Oi54NkmzJO69VQ>? MoTSV2FPT0WU
NOS-1 cell MYXHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MUPJcohq[mm2aX;uJI9nKGi3bXHuJG5QWy1zIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MT6zOlk2OyEQvF2= NXW2dVZ4W0GQR1XS
NUGC-3 cell MYjHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MnT1TY5pcWKrdHnvckBw\iCqdX3hckBPXUeFLUOgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xOk42QTB4IN88US=> M1n4OnNCVkeHUh?=
NY cell MoDTS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MkT1TY5pcWKrdHnvckBw\iCqdX3hckBPYSClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTNzLkG4OlQh|ryP MYTTRW5ITVJ?
OAW-42 cell MV;Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MUnJcohq[mm2aX;uJI9nKGi3bXHuJG9CXy12MjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUeuN|E2PjVizszN M3K1ZXNCVkeHUh?=
OCI-AML2 cell NUDSW|F5T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MnzLTY5pcWKrdHnvckBw\iCqdX3hckBQS0lvQV3MNkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVM{NjJ3M{Gg{txO MkfrV2FPT0WU
OCUB-M cell MUDHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MnT5TY5pcWKrdHnvckBw\iCqdX3hckBQS1WELV2gZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME23MlczOTV{IN88US=> M3n4OnNCVkeHUh?=
OE19 cell MYLHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MmPQTY5pcWKrdHnvckBw\iCqdX3hckBQTTF7IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Nz63OlY5PCEQvF2= M3vOTXNCVkeHUh?=
OE33 cell NF3sNIlIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NHrVdFhKdmirYnn0bY9vKG:oIHj1cYFvKE:HM{OgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlg5QTJ4IN88US=> MXjTRW5ITVJ?
OMC-1 cell MmH1S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MXrJcohq[mm2aX;uJI9nKGi3bXHuJG9OSy1zIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;OT6yOVA6QCEQvF2= NXX3dpZmW0GQR1XS
OS-RC-2 cell MVvHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NWn6bI1uUW6qaXLpeIlwdiCxZjDoeY1idiCRUz3SR{0zKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:QC53MkOwO{DPxE1? MYPTRW5ITVJ?
OVCAR-3 cell NX7BdHZsT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NH25WW1KdmirYnn0bY9vKG:oIHj1cYFvKE:YQ1HSMVMh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yNjh2NEG1JO69VQ>? NHqye|dUSU6JRWK=
OVCAR-4 cell NHLCVppIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NUPtSJlMUW6qaXLpeIlwdiCxZjDoeY1idiCRVlPBVk01KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OzBwNE[2JO69VQ>? NYHIRm54W0GQR1XS
P12-ICHIKAWA cell M4PkfWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MoO1TY5pcWKrdHnvckBw\iCqdX3hckBROTJvSVPITWtCX0FiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1zND63Olg{KM7:TR?= M2frZXNCVkeHUh?=
P30-OHK cell NXz4cG1lT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M3fvbWlvcGmkaYTpc44hd2ZiaIXtZY4hWDNyLV;IT{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVQvPTN4IN88US=> M{TRZXNCVkeHUh?=
PA-1 cell NWLzO4c5T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MlXLTY5pcWKrdHnvckBw\iCqdX3hckBRSS1zIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;OT6wO|YyPSEQvF2= Ml3qV2FPT0WU
PANC-03-27 cell NHjs[VZIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NWXtPGJuUW6qaXLpeIlwdiCxZjDoeY1idiCSQV7DMVA{NTJ5IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;OD63NVA5OiEQvF2= MnLhV2FPT0WU
PANC-10-05 cell NX;POYRDT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NY\0RllZUW6qaXLpeIlwdiCxZjDoeY1idiCSQV7DMVExNTB3IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MUSuPVk2QSEQvF2= M{G1UHNCVkeHUh?=
PC-3 cell MYrHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M2TEU2lvcGmkaYTpc44hd2ZiaIXtZY4hWENvMzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGwMlUyOzVizszN NUXlOFFGW0GQR1XS
PF-382 cell NVvneHZCT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NYT0eVBuUW6qaXLpeIlwdiCxZjDoeY1idiCSRj2zPFIh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yOS54OEK4JO69VQ>? MVjTRW5ITVJ?
RCC10RGB cell M4T2SGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NU\GVppDUW6qaXLpeIlwdiCxZjDoeY1idiCUQ1OxNHJISiClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRThwNkW2O{DPxE1? NH72UldUSU6JRWK=
RD cell M4rmcGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NVviTXBWUW6qaXLpeIlwdiCxZjDoeY1idiCURDDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUKwMlYxOzZizszN M1:xTnNCVkeHUh?=
REH cell Mo\4S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MVHJcohq[mm2aX;uJI9nKGi3bXHuJHJGUCClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTFzLkS4PFMh|ryP MVzTRW5ITVJ?
RERF-LC-MS cell MWXHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M2HldmlvcGmkaYTpc44hd2ZiaIXtZY4hWkWURj3MR{1OWyClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTJ4LkGzOFch|ryP MlOzV2FPT0WU
RKO cell NXTjO3pET3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NETEVYxKdmirYnn0bY9vKG:oIHj1cYFvKFKNTzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUG5MlQ1OzlizszN NYHjOFM2W0GQR1XS
RO82-W-1 cell MW\Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? Mn[2TY5pcWKrdHnvckBw\iCqdX3hckBTVzh{LWetNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVQ4NjJ5OEOg{txO MljHV2FPT0WU
RPMI-2650 cell NXvHUmRmT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NXL1OFVIUW6qaXLpeIlwdiCxZjDoeY1idiCUUF3JMVI3PTBiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD13Lke3PVQ4KM7:TR?= M2TPfnNCVkeHUh?=
RPMI-8402 cell MnqyS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MWrJcohq[mm2aX;uJI9nKGi3bXHuJHJRVUlvOESwNkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVE3NjN2MzFOwG0> NX;oO2o4W0GQR1XS
RS4-11 cell MUHHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NGnUR5ZKdmirYnn0bY9vKG:oIHj1cYFvKFKVND2xNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVYvPjh4NEWg{txO NFjOUXJUSU6JRWK=
RT-112 cell MVvHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MUHJcohq[mm2aX;uJI9nKGi3bXHuJHJVNTFzMjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPU[uO|E6PTJizszN MnPjV2FPT0WU
RVH-421 cell MXnHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M4TudmlvcGmkaYTpc44hd2ZiaIXtZY4hWl[KLUSyNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVMzNjN4ME[g{txO NIDNWJpUSU6JRWK=
RXF393 cell NHL3c|VIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NXjaU21pUW6qaXLpeIlwdiCxZjDoeY1idiCUWF[zPVMh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0zOC53OE[zJO69VQ>? NWGzZoRUW0GQR1XS
SBC-5 cell M3;3bWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M4r4[WlvcGmkaYTpc44hd2ZiaIXtZY4hW0KFLUWgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yNE45OzJ3IN88US=> NXHOZmN1W0GQR1XS
SCC-25 cell Ml3tS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NFzafpVKdmirYnn0bY9vKG:oIHj1cYFvKFOFQz2yOUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVE2NjhzN{mg{txO M3z3XnNCVkeHUh?=
SCC-4 cell M{THN2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MnTlTY5pcWKrdHnvckBw\iCqdX3hckBUS0NvNDDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUmuOVkzQDNizszN MlHyV2FPT0WU
SCC-9 cell MYDHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? Mkm1TY5pcWKrdHnvckBw\iCqdX3hckBUS0NvOTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUOuNFg2OzZizszN NGjKRWJUSU6JRWK=
SF126 cell M{Hi[2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NXq3fI5JUW6qaXLpeIlwdiCxZjDoeY1idiCVRkGyOkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVExNjZ5NE[g{txO NWDmcXdtW0GQR1XS
SF268 cell M1uzeWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MWLJcohq[mm2aX;uJI9nKGi3bXHuJHNHOjZ6IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MUWuNVM5PyEQvF2= NF3zb2FUSU6JRWK=
SF295 cell M1;CW2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NYHyc41pUW6qaXLpeIlwdiCxZjDoeY1idiCVRkK5OUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVE{NjZzOEOg{txO MX3TRW5ITVJ?
SIG-M5 cell NYD0cVZGT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NGqxUVhKdmirYnn0bY9vKG:oIHj1cYFvKFOLRz3NOUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEzNjZ4MESg{txO NVnsO3lzW0GQR1XS
SJSA-1 cell NEnRcFZIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MofpTY5pcWKrdHnvckBw\iCqdX3hckBUUlODLUGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2zOk46ODd{IN88US=> NEjZ[ZdUSU6JRWK=
SK-CO-1 cell Mlq0S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MmDCTY5pcWKrdHnvckBw\iCqdX3hckBUUy2FTz2xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NVAvPjN7NDFOwG0> NVW5bpZ2W0GQR1XS
SK-LMS-1 cell M4rJdGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 Mm\RTY5pcWKrdHnvckBw\iCqdX3hckBUUy2OTWOtNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVgvPzZ2NUKg{txO Mn3LV2FPT0WU
SK-LU-1 cell M{T6[2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NITlb5JKdmirYnn0bY9vKG:oIHj1cYFvKFONLVzVMVEh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF01Oi5yNEOg{txO M4K0XHNCVkeHUh?=
SK-MEL-24 cell MVnHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M1XWVWlvcGmkaYTpc44hd2ZiaIXtZY4hW0tvTVXMMVI1KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OTNwMU[3OUDPxE1? NHrKXnBUSU6JRWK=
SK-MEL-3 cell MmjoS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NWGwVoJbUW6qaXLpeIlwdiCxZjDoeY1idiCVSz3NSWwuOyClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTJzLkS2PVYh|ryP MY\TRW5ITVJ?
SK-MES-1 cell MUPHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M333OmlvcGmkaYTpc44hd2ZiaIXtZY4hW0tvTVXTMVEh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0zNjFyMEm2JO69VQ>? MX3TRW5ITVJ?
human SN12C cell NWTwTZQ3T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NV\GeJN5UW6qaXLpeIlwdiCxZjDoeY1idiCVTkGyR{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVE4NjF7Nkeg{txO MX7TRW5ITVJ?
SNB75 cell NUHBWYp1T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MlTGTY5pcWKrdHnvckBw\iCqdX3hckBUVkJ5NTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUeuPFI6PyEQvF2= MYTTRW5ITVJ?
SNU-387 cell MW\Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NUjrcoZpUW6qaXLpeIlwdiCxZjDoeY1idiCVTmWtN|g4KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:PC5zOUW0OEDPxE1? NGXPSIpUSU6JRWK=
SNU-423 cell MkflS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NVixdWhrUW6qaXLpeIlwdiCxZjDoeY1idiCVTmWtOFI{KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:PS57NEmzN{DPxE1? NHTFXlRUSU6JRWK=
SNU-C1 cell NGixOG1Iem:5dHigbY5pcWKrdHnvckBie3OjeR?= NH\aUmNKdmirYnn0bY9vKG:oIHj1cYFvKFOQVT3DNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIvODB7NEig{txO MULTRW5ITVJ?
SNU-C2B cell NX7lUWp2T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NXvBfWt2UW6qaXLpeIlwdiCxZjDoeY1idiCVTmWtR|JDKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OjJwMk[3N{DPxE1? MmG4V2FPT0WU
SR cell M4n1Rmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MXTJcohq[mm2aX;uJI9nKGi3bXHuJHNTKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OTNwMEe0OkDPxE1? MVPTRW5ITVJ?
SU-DHL-1 cell MnrXS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NVr6RmNQUW6qaXLpeIlwdiCxZjDoeY1idiCVVT3ETGwuOSClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTZwOEG1OFMh|ryP Ml7PV2FPT0WU
SW1710 cell NH3MfmpIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NXLCSmFOUW6qaXLpeIlwdiCxZjDoeY1idiCVV{G3NVAh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yNjN6OEmyJO69VQ>? NHrmSGxUSU6JRWK=
SW780 cell MnXQS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MUPJcohq[mm2aX;uJI9nKGi3bXHuJHNYPzhyIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;ND64PVM2QCEQvF2= MofLV2FPT0WU
SW872 cell NULPXJZsT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NWLKe4UyUW6qaXLpeIlwdiCxZjDoeY1idiCVV{i3NkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVE1NjF2M{Wg{txO M3y2XHNCVkeHUh?=
SW954 cell NF\0cnVIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MULJcohq[mm2aX;uJI9nKGi3bXHuJHNYQTV2IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;NT64OVc5OyEQvF2= NV;WfoFtW0GQR1XS
T47D cell MUTHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? Mnz6TY5pcWKrdHnvckBw\iCqdX3hckBVPDeGIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MD61NVYzKM7:TR?= NVPjXnlFW0GQR1XS
22RV1 cell MX;Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NHXT[4JKdmirYnn0bY9vKG:oIHj1cYFvKDJ{Um[xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Ok43OTR{NDFOwG0> MYrTRW5ITVJ?
23132-87 cell MoPZS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? Mme1TY5pcWKrdHnvckBw\iCqdX3hckAzOzF|Mj24O{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVAvPzV7M{ig{txO Ml\LV2FPT0WU
639-V cell Mn;2S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NYm2c4NKUW6qaXLpeIlwdiCxZjDoeY1idiB4M{mtWkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVUvQDd5MzFOwG0> NWHabY5OW0GQR1XS
697 cell NX;DXFBDT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MV3Jcohq[mm2aX;uJI9nKGi3bXHuJFY6PyClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTdwMUe3OFYh|ryP MYPTRW5ITVJ?
769-P cell NFz3OpdIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MkTKTY5pcWKrdHnvckBw\iCqdX3hckA4PjlvUDDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGuNVA1QDNizszN M1:wN3NCVkeHUh?=
8-MG-BA cell NWPQRZp{T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NEeyO|lKdmirYnn0bY9vKG:oIHj1cYFvKDhvTVetRmEh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF05NjZ|NECxJO69VQ>? M{T6T3NCVkeHUh?=
A4-Fuk cell MV;Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NImzfmNKdmirYnn0bY9vKG:oIHj1cYFvKEF2LV\1b{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEvQDV6MzFOwG0> Mlq1V2FPT0WU
A427 cell NIj6UWdIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NFLFfmVKdmirYnn0bY9vKG:oIHj1cYFvKEF2MkegZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2zMlA4Pjl|IN88US=> M4XxWHNCVkeHUh?=
A498 cell M4X3R2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NUi4TohWUW6qaXLpeIlwdiCxZjDoeY1idiCDNEm4JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU4xQDF|NDFOwG0> M3HsbXNCVkeHUh?=
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MDA-MB-468 cell NGTOb4FIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NWrpNJFPUW6qaXLpeIlwdiCxZjDoeY1idiCPRFGtUWIuPDZ6IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Mz63NFc4OyEQvF2= NFrud3NUSU6JRWK=
ME-180 cell NHrGVVFIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M3[zcGlvcGmkaYTpc44hd2ZiaIXtZY4hVUVvMUiwJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9N{4yPTBzMTFOoI0> MmLXV2FPT0WU
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... Click to View More Cell Line Experimental Data

In vivo In mice, Akti-1/2 (50 mg/kg, i.p.) inhibits basal and IGF-stimulated Akt1 and Akt2 phosphorylation in lung. [1]

Protocol

Kinase Assay:[2]
+ Expand

Kinase screen:

Briefly, all assays (25.5 μl at 21°C for 30 min) are performed using a Biomek 2000 Laboratory Automation Workstation in a 96-well format. Reactions contains 5–20 mU purified kinase along with substrate peptide or protein and are initiated by the addition of 10 mM MgAcetate and 5, 20, or 50 μM ATP ([γ-33P]-ATP, 800 cpm/pmol).
Cell Research:[4 ]
+ Expand
  • Cell lines: HCC827, NCI-H522, NCI-1651, and PC-9 cells
  • Concentrations: ~10 μM
  • Incubation Time: 96 h
  • Method: The cell growth inhibitory effect of AKTi-1/2 is studied using the 96 h sulforhodamine B assay (SRB). Drug concentrations that inhibited 50% of cell growth (IC50) are calculated for each compound in GraphPad Prism 6.0 using non-linear regression analysis and sigmoidal dose–response (variable slope) equation.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 22 mg/mL (39.88 mM)
Water Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 551.64
Formula

C34H29N7O

CAS No. 612847-09-3
Storage powder
Synonyms Akt Inhibitor VIII

Bio Calculators

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    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

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