Akti-1/2

Catalog No.S7776 Synonyms: Akt Inhibitor VIII

Akti-1/2 Chemical Structure

Molecular Weight(MW): 551.64

Akti-1/2 is a highly selective Akt1/Akt2 inhibitor with IC50 of 58 nM/210 nM, respectively, about 36-fold selectivity for Akt1 over Akt3.

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  • AKTi-1/2 inhibits human HCC cells in vitro. Human HCC HepG2 cells (A–F), Huh-7 cells (G), primary human HCC cells (“Pri HCC”, G) or the primary liver cells (“Pri liver cells”, G) were treated with/out applied concentrations of AKTi-1/2 for indicated time; Cell survival (A, B and G), proliferation (C and D) and apoptosis (E and F) were tested by the listed assays. Data were shown as the mean (n = 5) with the standard deviation (SD). Experiments in this figure were repeated three times, with similar results were obtained. *P < 0.05 vs. “C” (untreated control) group.

    Biochem Biophys Res Commun, 2016, 480(3):334-340. Akti-1/2 purchased from Selleck.

    Autophagy inhibitors sensitize AKTi-1/2-induced cytotoxicity against HCC cells. HepG2 cells were treated with/out AKTi-1/2 (5/10 μM) for indicated time; Listed proteins were tested by Western blot assay (A); The percentage of LC3B-II GFP puncta positive cells ("autophagic cells") was calculated (B). HepG2 cells, pretreated with 3-methyladenine (“3 MA”, 10 mM), ammonium chloride (“NH4Cl”, 1 mM) or bafilomycin A1 (“BafA1”, 1 μM) for 1 h, were treated with AKTi-1/2 (10 μM) for applied time; Cell survival (CCK-8 assay, C) were tested. The IC50 was also determined (D).

    Biochem Biophys Res Commun, 2016, 480(3):334-340.. Akti-1/2 purchased from Selleck.

Purity & Quality Control

Choose Selective Akt Inhibitors

Biological Activity

Description Akti-1/2 is a highly selective Akt1/Akt2 inhibitor with IC50 of 58 nM/210 nM, respectively, about 36-fold selectivity for Akt1 over Akt3.
Targets
Akt1 [1]
(Cell-free assay)
Akt2 [1]
(Cell-free assay)
Akt3 [1]
(Cell-free assay)
58 nM 210 nM 2119 nM
In vitro

In a cell-based IPKA (C33A) assay, Akti-1/2 inhibits Akt1 and Akt2 with IC50 of 305 nM and 2086 nM, respectively. In HT29, MCF7, and A2780 cells, Akti-1/2 induces cell apoptosis by dramatically increasing caspase-3 activity. [1] In liver cells, Akti-1/2 blocks insulin regulation of PEPCK, G6Pase expression, and FOXO1 activity. [2] Akti-1/2 also strongly potentiates PAR-1-mediated platelet aggregation by blocking PKB. [3] In HCC827, NCI-H522, NCI-1651, and PC-9 cells, Akti-1/2 inhibits cell growth with IC50 of 4.7 μM, 7.25 μM, and 9.5 μM, when in combination with gefitinib, Akti-1/2 causes enhanced inhibition of cell growth and apoptosis. [4]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
MDA-MB-468 cells Mo\SR5l1d3SxeHnjbZR6KGG|c3H5 MVOxNEDPxE1? NULHOWJZS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hVUSDLV3CMVQ3QCClZXzsd{BqdiCycnXz[Y5k\SCxZjCxNEB2VSClaHzvdo9yfWmwZTDifUBUWkJiYYPzZZktKEeLNUC9Nk43PiEQvF2= Mn3yNVg3QTF6OUS=
MDA-MB-231 cells MnL6R5l1d3SxeHnjbZR6KGG|c3H5 MlTqNVAh|ryP NFvpPHdEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBOTEFvTVKtNlMyKGOnbHzzJIlvKHC{ZYPlcoNmKG:oIEGwJJVOKGOqbH;yc5F2cW6nIHL5JHNTSiCjc4PhfUwhT0l3ME20MlU2KM7:TR?= NXLGemR{OTh4OUG4PVQ>
MCF7 cells NH3xV|NEgXSxdH;4bYNqfHliYYPzZZk> MnLCNVAh|ryP MV\DfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDNR2Y4KGOnbHzzJIlvKHC{ZYPlcoNmKG:oIEGwJJVOKGOqbH;yc5F2cW6nIHL5JHNTSiCjc4PhfUwhT0l3ME2wMlQyKM7:TR?= NV6wSoZZOTh4OUG4PVQ>
184B5 cells M3faSGN6fG:2b4jpZ4l1gSCjc4PhfS=> MmrlNlAh|ryP NHjTNFFEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckAyQDSENTDj[YxteyCjdDCyNEB2VSClaHzvdo9yfWmwZTDifUBUWkJiYYPzZZktKEeLNUC9NlUvPzZizszN NVX5OI5uOTh4OUG4PVQ>
NCI-H1563 cell MlfIS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NV7JbXRYUW6qaXLpeIlwdiCxZjDoeY1idiCQQ1mtTFE2PjNiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1yLkW0NlQ3KM7:TR?= MnS0V2FPT0WU
NCI-H1618 cel MnfqS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NUH0[5g4UW6qaXLpeIlwdiCxZjDoeY1idiCQQ1mtTFE3OThiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1{MT65PVgzKM7:TR?= M2n6bXNCVkeHUh?=
NCI-H1623 cell NYC5bYV{T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M{HKZWlvcGmkaYTpc44hd2ZiaIXtZY4hVkOLLVixOlI{KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OTVwMEW5OkDPxE1? M3;jcHNCVkeHUh?=
NCI-H1648 cell M33pU2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MY\Jcohq[mm2aX;uJI9nKGi3bXHuJG5EUS2KMU[0PEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVUvPzV3MTFOwG0> NWjoUYlzW0GQR1XS
NCI-H1650 cell MnvmS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NHjQN|dKdmirYnn0bY9vKG:oIHj1cYFvKE6FST3INVY2OCClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTFzLkWxN|Qh|ryP MlvCV2FPT0WU
NCI-H1651 cell MXrHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MmfKTY5pcWKrdHnvckBw\iCqdX3hckBPS0lvSEG2OVEh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yPi52M{O4JO69VQ>? NFLJR3lUSU6JRWK=
NCI-H1703 cell NVP2fXo3T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NX\kRoZXUW6qaXLpeIlwdiCxZjDoeY1idiCQQ1mtTFE4ODNiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1zNT61O|ch|ryP NFPoVmFUSU6JRWK=
NCI-H1734 cell MYnHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NWfVO5ZuUW6qaXLpeIlwdiCxZjDoeY1idiCQQ1mtTFE4OzRiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1zMD63O|g5KM7:TR?= NHnXcpRUSU6JRWK=
NCI-H1755 cell NEPIfphIem:5dHigbY5pcWKrdHnvckBie3OjeR?= Mo[3TY5pcWKrdHnvckBw\iCqdX3hckBPS0lvSEG3OVUh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yNjB3NUOxJO69VQ>? MnrIV2FPT0WU
NCI-H1770 cell MkjRS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M1XkO2lvcGmkaYTpc44hd2ZiaIXtZY4hVkOLLVixO|cxKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OzRwMUe5N{DPxE1? NWPEVlAxW0GQR1XS
NCI-H1792 cell NEPaWHhIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NFzaSoFKdmirYnn0bY9vKG:oIHj1cYFvKE6FST3INVc6OiClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTJ7LkizO|kh|ryP MVTTRW5ITVJ?
NCI-H1963 cell M4S4b2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M1\Ld2lvcGmkaYTpc44hd2ZiaIXtZY4hVkOLLVixPVY{KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OTlwN{S5OEDPxE1? MojyV2FPT0WU
NCI-H1993 cell MYXHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MoriTY5pcWKrdHnvckBw\iCqdX3hckBPS0lvSEG5PVMh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0zOi54MUWg{txO NITWUWpUSU6JRWK=
NCI-H2009 cell M3rpTWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NVvsVWdmUW6qaXLpeIlwdiCxZjDoeY1idiCQQ1mtTFIxODliY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD15LkO5NFE6KM7:TR?= NVzOfo53W0GQR1XS
NCI-H2030 cell MUnHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M3;mdWlvcGmkaYTpc44hd2ZiaIXtZY4hVkOLLViyNFMxKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OS57NES4N{DPxE1? MmmzV2FPT0WU
NCI-H2122 cell NHe2RW1Iem:5dHigbY5pcWKrdHnvckBie3OjeR?= MkLOTY5pcWKrdHnvckBw\iCqdX3hckBPS0lvSEKxNlIh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yOC5zM{i1JO69VQ>? M1X1WXNCVkeHUh?=
NCI-H2126 cell NGDoS2RIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MVvJcohq[mm2aX;uJI9nKGi3bXHuJG5EUS2KMkGyOkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEzNjN|N{Gg{txO M3XjXXNCVkeHUh?=
NCI-H2170 cell NU\RXXI{T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NH\Ubo9KdmirYnn0bY9vKG:oIHj1cYFvKE6FST3INlE4OCClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTF6LkGwNlgh|ryP MXLTRW5ITVJ?
NCI-H2196 cell NYH5WnNbT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NF\ZTI9KdmirYnn0bY9vKG:oIHj1cYFvKE6FST3INlE6PiClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTJ2LkiwNFMh|ryP NI\xbYtUSU6JRWK=
NCI-H2228 cell MXLHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NUjE[nM3UW6qaXLpeIlwdiCxZjDoeY1idiCQQ1mtTFIzOjhiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1{LkK4OlA1KM7:TR?= NFTOeppUSU6JRWK=
NCI-H2342 cell NWjaZmNDT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= Mo[zTY5pcWKrdHnvckBw\iCqdX3hckBPS0lvSEKzOFIh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0xNjl|N{e5JO69VQ>? MojFV2FPT0WU
NCI-H2347 cell MVHHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NVrFXGR3UW6qaXLpeIlwdiCxZjDoeY1idiCQQ1mtTFI{PDdiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1zNj6xOVgyKM7:TR?= NXm2PJljW0GQR1XS
NCI-H2405 cell MoPvS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MmfTTY5pcWKrdHnvckBw\iCqdX3hckBPS0lvSEK0NFUh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yOC52MkGyJO69VQ>? NUjuU2pnW0GQR1XS
NCI-H2452 cell M2DC[mdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NVPEOWtsUW6qaXLpeIlwdiCxZjDoeY1idiCQQ1mtTFI1PTJiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1{Nj62OVk1KM7:TR?= Mo\vV2FPT0WU
NCI-H292 cell NY\SXGJoT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NIXhWmNKdmirYnn0bY9vKG:oIHj1cYFvKE6FST3INlkzKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:Pi5yNEizO{DPxE1? M2rIXXNCVkeHUh?=
NCI-H345 cell M3;RXWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M13hWGlvcGmkaYTpc44hd2ZiaIXtZY4hVkOLLVizOFUh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yPi5{N{C2JO69VQ>? M1z0UnNCVkeHUh?=
NCI-H358 cell NUn4NI86T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NEnqRYNKdmirYnn0bY9vKG:oIHj1cYFvKE6FST3IN|U5KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OTlwN{KzN{DPxE1? MofQV2FPT0WU
NCI-H460 cell NEPZZ3BIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MWPJcohq[mm2aX;uJI9nKGi3bXHuJG5EUS2KNE[wJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9OE43Ojl7MzFOwG0> NVX3Um9QW0GQR1XS
NCI-H520 cell NUjMRVhuT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NWfWbGxqUW6qaXLpeIlwdiCxZjDoeY1idiCQQ1mtTFUzOCClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTFwMUOzNFMh|ryP MUPTRW5ITVJ?
NCI-H522 cell NVnPb20yT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NInDemJKdmirYnn0bY9vKG:oIHj1cYFvKE6FST3IOVIzKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OTFwMEi3OEDPxE1? NI\BNmJUSU6JRWK=
NCI-H526 cell MXjHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MoO4TY5pcWKrdHnvckBw\iCqdX3hckBPS0lvSEWyOkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIzNjh6N{ROwG0> NFvOfWhUSU6JRWK=
NCI-H596 MVrHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NYLZV4pnUW6qaXLpeIlwdiCxZjDoeY1idiCQQ1mtTFU6PiClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTF5LkW3NFgh|ryP NUHjTnJnW0GQR1XS
NCI-H630 cell NE\Kb5FIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NIX1UmJKdmirYnn0bY9vKG:oIHj1cYFvKE6FST3IOlMxKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:PS53MUC1OUDPxE1? NYXqNFRVW0GQR1XS
NCI-H64 cell NUnYUFJXT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NHLvXYhKdmirYnn0bY9vKG:oIHj1cYFvKE6FST3IOlQh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yOi53NEOxJO69VQ>? NUfObolOW0GQR1XS
NCI-H650 cell MmW0S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MYPJcohq[mm2aX;uJI9nKGi3bXHuJG5EUS2KNkWwJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9O{42QTh5NzFOwG0> NX6xSpVDW0GQR1XS
NCI-H661 cell NXu0U482T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NYDyboNvUW6qaXLpeIlwdiCxZjDoeY1idiCQQ1mtTFY3OSClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTVwNEKzNlYh|ryP NYK2[YRCW0GQR1XS
NCI-H747 cell NICxO41Iem:5dHigbY5pcWKrdHnvckBie3OjeR?= NWjYSW1rUW6qaXLpeIlwdiCxZjDoeY1idiCQQ1mtTFc1PyClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTdwNkK3PVkh|ryP MYrTRW5ITVJ?
NCI-H838 cell MlPUS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MUDJcohq[mm2aX;uJI9nKGi3bXHuJG5EUS2KOEO4JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9N|EvPDFzODFOwG0> MWPTRW5ITVJ?
NCI-N87 cell M{TBO2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MVXJcohq[mm2aX;uJI9nKGi3bXHuJG5EUS2QOEegZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yPU4{ODR{IN88US=> MXLTRW5ITVJ?
NH-12 cell M1PvNmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M1ez[WlvcGmkaYTpc44hd2ZiaIXtZY4hVkhvMUKgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2wMlYxQDZ2IN88US=> MkDaV2FPT0WU
NKM-1 cell NIHHeIpIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MnTuTY5pcWKrdHnvckBw\iCqdX3hckBPU01vMTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUKuO|U6OjNizszN NHW2SHZUSU6JRWK=
NMC-G1 cell MlHoS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NWnEdohPUW6qaXLpeIlwdiCxZjDoeY1idiCQTVOtS|Eh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF01Oi54NkmzJO69VQ>? MmDIV2FPT0WU
NOS-1 cell MVnHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MVrJcohq[mm2aX;uJI9nKGi3bXHuJG5QWy1zIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MT6zOlk2OyEQvF2= NH;RZmlUSU6JRWK=
NUGC-3 cell NG[3b5BIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NHTXTnlKdmirYnn0bY9vKG:oIHj1cYFvKE6XR1OtN{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVE3NjV7ME[g{txO M3PkcXNCVkeHUh?=
NY cell NHTF[nFIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MkfMTY5pcWKrdHnvckBw\iCqdX3hckBPYSClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTNzLkG4OlQh|ryP NILBcFFUSU6JRWK=
OAW-42 cell M1SxN2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NGXHTGdKdmirYnn0bY9vKG:oIHj1cYFvKE:DVz20NkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVcvOzF3NkWg{txO NHjSXGdUSU6JRWK=
OCI-AML2 cell NUfRemp2T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= Moj4TY5pcWKrdHnvckBw\iCqdX3hckBQS0lvQV3MNkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVM{NjJ3M{Gg{txO M2q1enNCVkeHUh?=
OCUB-M cell NWW3PW1GT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M2SwWGlvcGmkaYTpc44hd2ZiaIXtZY4hV0OXQj3NJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9O{44OjF3MjFOwG0> NYH0S4lyW0GQR1XS
OE19 cell NWDq[IJHT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MoT6TY5pcWKrdHnvckBw\iCqdX3hckBQTTF7IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Nz63OlY5PCEQvF2= MnHlV2FPT0WU
OE33 cell M2XCXWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MnzrTY5pcWKrdHnvckBw\iCqdX3hckBQTTN|IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MT64PFkzPiEQvF2= MljjV2FPT0WU
OMC-1 cell MlXuS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NVrSeGVnUW6qaXLpeIlwdiCxZjDoeY1idiCRTVOtNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVkvOjVyOUig{txO MYrTRW5ITVJ?
OS-RC-2 cell NFLOTWJIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MYXJcohq[mm2aX;uJI9nKGi3bXHuJG9UNVKFLUKgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME24MlUzOzB5IN88US=> M4XhfXNCVkeHUh?=
OVCAR-3 cell NGTne2VIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NXi4PG9kUW6qaXLpeIlwdiCxZjDoeY1idiCRVlPBVk0{KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OS56NESxOUDPxE1? M3qwSXNCVkeHUh?=
OVCAR-4 cell NIrHToxIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MY\Jcohq[mm2aX;uJI9nKGi3bXHuJG9XS0GULUSgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2zNE41PjZizszN M{TyWHNCVkeHUh?=
P12-ICHIKAWA cell NUD4UW9ET3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MY\Jcohq[mm2aX;uJI9nKGi3bXHuJHAyOi2LQ1jJT2FYSSClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTF2Lke2PFMh|ryP MXnTRW5ITVJ?
P30-OHK cell M1jiOWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M174cGlvcGmkaYTpc44hd2ZiaIXtZY4hWDNyLV;IT{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVQvPTN4IN88US=> NWO5PJFTW0GQR1XS
PA-1 cell MknIS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MVrJcohq[mm2aX;uJI9nKGi3bXHuJHBCNTFiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD17LkC3OlE2KM7:TR?= MWjTRW5ITVJ?
PANC-03-27 cell MnXhS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NUjtcVNiUW6qaXLpeIlwdiCxZjDoeY1idiCSQV7DMVA{NTJ5IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;OD63NVA5OiEQvF2= MlfzV2FPT0WU
PANC-10-05 cell NYqxR5dCT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NInteZJKdmirYnn0bY9vKG:oIHj1cYFvKFCDTlOtNVAuODViY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1zND65PVU6KM7:TR?= Mni0V2FPT0WU
PC-3 cell M3TuPWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NV;tcWhZUW6qaXLpeIlwdiCxZjDoeY1idiCSQz2zJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NVAvPTF|NTFOwG0> NIj3epBUSU6JRWK=
PF-382 cell NWnkXJZjT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M1mz[mlvcGmkaYTpc44hd2ZiaIXtZY4hWEZvM{iyJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NVEvPjh{ODFOwG0> MVrTRW5ITVJ?
RCC10RGB cell NIGwXpVIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NETXemRKdmirYnn0bY9vKG:oIHj1cYFvKFKFQ{GwVmdDKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:QC54NU[3JO69VQ>? NUjy[nNNW0GQR1XS
RD cell M2LHWWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NFHrcoRKdmirYnn0bY9vKG:oIHj1cYFvKFKGIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MkCuOlA{PiEQvF2= M2rGe3NCVkeHUh?=
REH cell NW\iV3QyT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NEKxfGpKdmirYnn0bY9vKG:oIHj1cYFvKFKHSDDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGxMlQ5QDNizszN MVnTRW5ITVJ?
RERF-LC-MS cell NYTwU45wT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= Ml;BTY5pcWKrdHnvckBw\iCqdX3hckBTTVKILVzDMW1UKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OjZwMUO0O{DPxE1? NWPPPGdiW0GQR1XS
RKO cell NED6To1Iem:5dHigbY5pcWKrdHnvckBie3OjeR?= MorCTY5pcWKrdHnvckBw\iCqdX3hckBTU09iY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1zOT60OFM6KM7:TR?= MX\TRW5ITVJ?
RO82-W-1 cell MX\Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? Ml;BTY5pcWKrdHnvckBw\iCqdX3hckBTVzh{LWetNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVQ4NjJ5OEOg{txO M1zEbXNCVkeHUh?=
RPMI-2650 cell Moi3S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NEHaNVNKdmirYnn0bY9vKG:oIHj1cYFvKFKSTVmtNlY2OCClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTVwN{e5OFch|ryP NGjZZVdUSU6JRWK=
RPMI-8402 cell NGD3OJpIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M4nGN2lvcGmkaYTpc44hd2ZiaIXtZY4hWlCPST24OFAzKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OTZwM{SzJO69VQ>? NH2xN3FUSU6JRWK=
RS4-11 cell NUL2fnhlT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NIPrc3hKdmirYnn0bY9vKG:oIHj1cYFvKFKVND2xNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVYvPjh4NEWg{txO NUC4OFNHW0GQR1XS
RT-112 cell NVvCUY5JT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MXrJcohq[mm2aX;uJI9nKGi3bXHuJHJVNTFzMjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPU[uO|E6PTJizszN Ml\uV2FPT0WU
RVH-421 cell NVXQOWZ{T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MXfJcohq[mm2aX;uJI9nKGi3bXHuJHJXUC12MkGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2zNk4{PjB4IN88US=> MYHTRW5ITVJ?
RXF393 cell MXXHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M3fUOmlvcGmkaYTpc44hd2ZiaIXtZY4hWliIM{mzJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NlAvPTh4MzFOwG0> NVLUPFlxW0GQR1XS
SBC-5 cell NG\0bGZIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NUPlOHB5UW6qaXLpeIlwdiCxZjDoeY1idiCVQlOtOUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIxNjh|MkWg{txO M{XPcXNCVkeHUh?=
SCC-25 cell MnjQS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NF7WWJZKdmirYnn0bY9vKG:oIHj1cYFvKFOFQz2yOUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVE2NjhzN{mg{txO NH[3TYtUSU6JRWK=
SCC-4 cell MlLxS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NEHQdJJKdmirYnn0bY9vKG:oIHj1cYFvKFOFQz20JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9PU42QTJ6MzFOwG0> Mkn3V2FPT0WU
SCC-9 cell M1HxS2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MYPJcohq[mm2aX;uJI9nKGi3bXHuJHNESy17IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Mz6wPFU{PiEQvF2= NEXmPXVUSU6JRWK=
SF126 cell Mmr3S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NHK5bYVKdmirYnn0bY9vKG:oIHj1cYFvKFOIMUK2JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NVAvPjd2NjFOwG0> M2KyOHNCVkeHUh?=
SF268 cell M17zWWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MnXRTY5pcWKrdHnvckBw\iCqdX3hckBUTjJ4ODDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUG1MlE{QDdizszN M3XLenNCVkeHUh?=
SF295 cell NHvS[FRIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NWm2XZV2UW6qaXLpeIlwdiCxZjDoeY1idiCVRkK5OUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVE{NjZzOEOg{txO MVzTRW5ITVJ?
SIG-M5 cell NG\lSo1Iem:5dHigbY5pcWKrdHnvckBie3OjeR?= M37O[mlvcGmkaYTpc44hd2ZiaIXtZY4hW0mJLV21JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NVIvPjZyNDFOwG0> M4e3dHNCVkeHUh?=
SJSA-1 cell M3P6PWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NVvqOJdRUW6qaXLpeIlwdiCxZjDoeY1idiCVSmPBMVEh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0{Pi57MEeyJO69VQ>? M4jMXnNCVkeHUh?=
SK-CO-1 cell NFzaXlRIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M3vENGlvcGmkaYTpc44hd2ZiaIXtZY4hW0tvQ1:tNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVExNjZ|OUSg{txO MWrTRW5ITVJ?
SK-LMS-1 cell M3PmWmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M3PIXmlvcGmkaYTpc44hd2ZiaIXtZY4hW0tvTF3TMVEh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF05Njd4NEWyJO69VQ>? NW\jfpZ3W0GQR1XS
SK-LU-1 cell MVrHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M2TTPGlvcGmkaYTpc44hd2ZiaIXtZY4hW0tvTGWtNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVQzNjB2MzFOwG0> MkHHV2FPT0WU
SK-MEL-24 cell NGD6VotIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NGLZNJJKdmirYnn0bY9vKG:oIHj1cYFvKFONLV3FUE0zPCClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTF|LkG2O|Uh|ryP MnzwV2FPT0WU
SK-MEL-3 cell M3rOfGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NV[2bWd2UW6qaXLpeIlwdiCxZjDoeY1idiCVSz3NSWwuOyClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTJzLkS2PVYh|ryP MmHvV2FPT0WU
SK-MES-1 cell MkXvS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NHTZ[4RKdmirYnn0bY9vKG:oIHj1cYFvKFONLV3FV{0yKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:Oi5zMEC5OkDPxE1? MWDTRW5ITVJ?
human SN12C cell NVu2OI41T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NWHL[21bUW6qaXLpeIlwdiCxZjDoeY1idiCVTkGyR{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVE4NjF7Nkeg{txO M4LtV3NCVkeHUh?=
SNB75 cell M4\JS2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M{\lPWlvcGmkaYTpc44hd2ZiaIXtZY4hW06EN{WgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME23MlgzQTdizszN NVnQVmF3W0GQR1XS
SNU-387 cell Ml63S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M{nBXGlvcGmkaYTpc44hd2ZiaIXtZY4hW06XLUO4O{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVQvOTl3NESg{txO M{nVW3NCVkeHUh?=
SNU-423 cell NGTpUVJIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NYmxTYFnUW6qaXLpeIlwdiCxZjDoeY1idiCVTmWtOFI{KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:PS57NEmzN{DPxE1? NX33XIdyW0GQR1XS
SNU-C1 cell NFrUU|ZIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NYX6b4ZEUW6qaXLpeIlwdiCxZjDoeY1idiCVTmWtR|Eh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0zNjByOUS4JO69VQ>? MmjOV2FPT0WU
SNU-C2B cell MmX0S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NELMVYlKdmirYnn0bY9vKG:oIHj1cYFvKFOQVT3DNmIh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0zOi5{NkezJO69VQ>? M2LONXNCVkeHUh?=
SR cell MoLTS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MVrJcohq[mm2aX;uJI9nKGi3bXHuJHNTKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OTNwMEe0OkDPxE1? MXnTRW5ITVJ?
SU-DHL-1 cell NETwT4NIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MV;Jcohq[mm2aX;uJI9nKGi3bXHuJHNWNUSKTD2xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Ok45OTV2MzFOwG0> M1;JWnNCVkeHUh?=
SW1710 cell Mor5S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MXjJcohq[mm2aX;uJI9nKGi3bXHuJHNYOTdzMDDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGuN|g5QTJizszN MUDTRW5ITVJ?
SW780 cell MonZS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? Mmi2TY5pcWKrdHnvckBw\iCqdX3hckBUXzd6MDDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUSuPFk{PThizszN MVrTRW5ITVJ?
SW872 cell MYTHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M{T2VGlvcGmkaYTpc44hd2ZiaIXtZY4hW1d6N{KgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xOE4yPDN3IN88US=> NGjseGVUSU6JRWK=
SW954 cell NXLZc41ET3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M2nuTWlvcGmkaYTpc44hd2ZiaIXtZY4hW1d7NUSgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME21Mlg2Pzh|IN88US=> NGLTdmZUSU6JRWK=
T47D cell M{L3Xmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NIDQeXVKdmirYnn0bY9vKG:oIHj1cYFvKFR2N1SgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2wMlUyPjJizszN MVzTRW5ITVJ?
22RV1 cell M3TvOWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MXLJcohq[mm2aX;uJI9nKGi3bXHuJFIzWlZzIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Nj62NVQzPCEQvF2= MYTTRW5ITVJ?
23132-87 cell MoDtS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NUTTVmY6UW6qaXLpeIlwdiCxZjDoeY1idiB{M{GzNk05PyClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTBwN{W5N|gh|ryP MmX0V2FPT0WU
639-V cell NWm0RnY2T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MV;Jcohq[mm2aX;uJI9nKGi3bXHuJFY{QS2YIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;NT64O|c{KM7:TR?= NYTqVYQ6W0GQR1XS
697 cell MoG2S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MU\Jcohq[mm2aX;uJI9nKGi3bXHuJFY6PyClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTdwMUe3OFYh|ryP M3P4[nNCVkeHUh?=
769-P cell NYDP[G9YT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MoDGTY5pcWKrdHnvckBw\iCqdX3hckA4PjlvUDDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGuNVA1QDNizszN NEfpZVVUSU6JRWK=
8-MG-BA cell MVfHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M1LLOGlvcGmkaYTpc44hd2ZiaIXtZY4hQC2PRz3CRUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVgvPjN2MEGg{txO NXnTZ2xYW0GQR1XS
A4-Fuk cell MVvHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M1e4OWlvcGmkaYTpc44hd2ZiaIXtZY4hSTRvRoXrJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU45PTh|IN88US=> NID4d5FUSU6JRWK=
A427 cell M33wSWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MnrYTY5pcWKrdHnvckBw\iCqdX3hckBCPDJ5IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Mz6wO|Y6OyEQvF2= NXfYXm5LW0GQR1XS
A498 cell MYHHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NXHzfFlWUW6qaXLpeIlwdiCxZjDoeY1idiCDNEm4JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU4xQDF|NDFOwG0> NWLsZYdvW0GQR1XS
AN3-CA cell M4TKdGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MnLmTY5pcWKrdHnvckBw\iCqdX3hckBCVjNvQ1GgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlY2PjFzIN88US=> MmHFV2FPT0WU
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EFM-19 cell NGDm[FNIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M4HJeWlvcGmkaYTpc44hd2ZiaIXtZY4hTU[PLUG5JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NE42PjRyODFOwG0> MlrPV2FPT0WU
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MDA-MB-361 cell MVrHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M1j6cGlvcGmkaYTpc44hd2ZiaIXtZY4hVUSDLV3CMVM3OSClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTBwNEi5PVUh|ryP NXT2V3N[W0GQR1XS
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MDA-MB-468 cell Mk\GS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NIH0VmFKdmirYnn0bY9vKG:oIHj1cYFvKE2GQT3NRk01PjhiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1|LkewO|c{KM7:TR?= MlexV2FPT0WU
ME-180 cell NWH1e3RST3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M1;J[WlvcGmkaYTpc44hd2ZiaIXtZY4hVUVvMUiwJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9N{4yPTBzMTFOoI0> Mly5V2FPT0WU
NCI-H526 cells MnK2S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NHG2W4ZKdmirYnn0bY9vKG:oIFHreE1u\WSrYYTl[EBidnSrYYDvdJRwfGmlIHHjeIl3cXS7IHnuJIh2dWGwIF7DTU1JPTJ4IHPlcIx{KGG|c3Xzd4VlKGG|IHTpd5J2eHSrb36gc4YheHKxdHXpck1CeGGoLUGgZ49ueGyneDDheEA2OCC3TTDh[pRmeiB{NDDodpMh[nliV3XzeIVzdiCkbH;0JIFv[Wy7c3nz NWW3[2tbOTd4MEO1OFA>

... Click to View More Cell Line Experimental Data

In vivo In mice, Akti-1/2 (50 mg/kg, i.p.) inhibits basal and IGF-stimulated Akt1 and Akt2 phosphorylation in lung. [1]

Protocol

Kinase Assay:[2]
+ Expand

Kinase screen:

Briefly, all assays (25.5 μl at 21°C for 30 min) are performed using a Biomek 2000 Laboratory Automation Workstation in a 96-well format. Reactions contains 5–20 mU purified kinase along with substrate peptide or protein and are initiated by the addition of 10 mM MgAcetate and 5, 20, or 50 μM ATP ([γ-33P]-ATP, 800 cpm/pmol).
Cell Research:[4 ]
+ Expand
  • Cell lines: HCC827, NCI-H522, NCI-1651, and PC-9 cells
  • Concentrations: ~10 μM
  • Incubation Time: 96 h
  • Method: The cell growth inhibitory effect of AKTi-1/2 is studied using the 96 h sulforhodamine B assay (SRB). Drug concentrations that inhibited 50% of cell growth (IC50) are calculated for each compound in GraphPad Prism 6.0 using non-linear regression analysis and sigmoidal dose–response (variable slope) equation.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 22 mg/mL (39.88 mM)
Water Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 551.64
Formula

C34H29N7O

CAS No. 612847-09-3
Storage powder
Synonyms Akt Inhibitor VIII

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

  • Mass
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    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

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