Akti-1/2

Catalog No.S7776 Synonyms: Akt Inhibitor VIII

Akti-1/2 Chemical Structure

Molecular Weight(MW): 551.64

Akti-1/2 is a highly selective Akt1/Akt2 inhibitor with IC50 of 58 nM/210 nM, respectively, about 36-fold selectivity for Akt1 over Akt3.

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  • AKTi-1/2 inhibits human HCC cells in vitro. Human HCC HepG2 cells (A–F), Huh-7 cells (G), primary human HCC cells (“Pri HCC”, G) or the primary liver cells (“Pri liver cells”, G) were treated with/out applied concentrations of AKTi-1/2 for indicated time; Cell survival (A, B and G), proliferation (C and D) and apoptosis (E and F) were tested by the listed assays. Data were shown as the mean (n = 5) with the standard deviation (SD). Experiments in this figure were repeated three times, with similar results were obtained. *P < 0.05 vs. “C” (untreated control) group.

    Biochem Biophys Res Commun, 2016, 480(3):334-340. Akti-1/2 purchased from Selleck.

    Autophagy inhibitors sensitize AKTi-1/2-induced cytotoxicity against HCC cells. HepG2 cells were treated with/out AKTi-1/2 (5/10 μM) for indicated time; Listed proteins were tested by Western blot assay (A); The percentage of LC3B-II GFP puncta positive cells ("autophagic cells") was calculated (B). HepG2 cells, pretreated with 3-methyladenine (“3 MA”, 10 mM), ammonium chloride (“NH4Cl”, 1 mM) or bafilomycin A1 (“BafA1”, 1 μM) for 1 h, were treated with AKTi-1/2 (10 μM) for applied time; Cell survival (CCK-8 assay, C) were tested. The IC50 was also determined (D).

    Biochem Biophys Res Commun, 2016, 480(3):334-340.. Akti-1/2 purchased from Selleck.

Purity & Quality Control

Choose Selective Akt Inhibitors

Biological Activity

Description Akti-1/2 is a highly selective Akt1/Akt2 inhibitor with IC50 of 58 nM/210 nM, respectively, about 36-fold selectivity for Akt1 over Akt3.
Targets
Akt1 [1]
(Cell-free assay)
Akt2 [1]
(Cell-free assay)
Akt3 [1]
(Cell-free assay)
58 nM 210 nM 2119 nM
In vitro

In a cell-based IPKA (C33A) assay, Akti-1/2 inhibits Akt1 and Akt2 with IC50 of 305 nM and 2086 nM, respectively. In HT29, MCF7, and A2780 cells, Akti-1/2 induces cell apoptosis by dramatically increasing caspase-3 activity. [1] In liver cells, Akti-1/2 blocks insulin regulation of PEPCK, G6Pase expression, and FOXO1 activity. [2] Akti-1/2 also strongly potentiates PAR-1-mediated platelet aggregation by blocking PKB. [3] In HCC827, NCI-H522, NCI-1651, and PC-9 cells, Akti-1/2 inhibits cell growth with IC50 of 4.7 μM, 7.25 μM, and 9.5 μM, when in combination with gefitinib, Akti-1/2 causes enhanced inhibition of cell growth and apoptosis. [4]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
MDA-MB-468 cells NFLRRZlEgXSxdH;4bYNqfHliYYPzZZk> NIjWUGEyOCEQvF2= NXnSRVJnS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hVUSDLV3CMVQ3QCClZXzsd{BqdiCycnXz[Y5k\SCxZjCxNEB2VSClaHzvdo9yfWmwZTDifUBUWkJiYYPzZZktKEeLNUC9Nk43PiEQvF2= NEm3TZgyQDZ7MUi5OC=>
MDA-MB-231 cells M{K3NWN6fG:2b4jpZ4l1gSCjc4PhfS=> MkTMNVAh|ryP M3PFV2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG1FSS2PQj2yN|Eh[2WubIOgbY4heHKnc3XuZ4Uhd2ZiMUCgeW0h[2iub4LvdZVqdmViYomgV3JDKGG|c3H5MEBIUTVyPUSuOVUh|ryP MWixPFY6OTh7NB?=
MCF7 cells NIXX[49EgXSxdH;4bYNqfHliYYPzZZk> MVKxNEDPxE1? NFnnUnBEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBOS0Z5IHPlcIx{KGmwIIDy[ZNmdmOnIH;mJFExKHWPIHPocI9zd3G3aX7lJIJ6KFOUQjDhd5NigSxiR1m1NF0xNjRzIN88US=> NVm4NJA3OTh4OUG4PVQ>
184B5 cells NInBdHBEgXSxdH;4bYNqfHliYYPzZZk> NX;HcY9pOjBizszN Mn7TR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gNVg1SjViY3XscJMh[XRiMkCgeW0h[2iub4LvdZVqdmViYomgV3JDKGG|c3H5MEBIUTVyPUK1Mlc3KM7:TR?= M4Tke|E5PjlzOEm0
NCI-H1563 cell NUnqZ45TT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MkLmTY5pcWKrdHnvckBw\iCqdX3hckBPS0lvSEG1OlMh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0xNjV2MkS2JO69VQ>? NYr4PHo2W0GQR1XS
NCI-H1618 cel NYruR5lqT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NEnsW3RKdmirYnn0bY9vKG:oIHj1cYFvKE6FST3INVYyQCClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTJzLkm5PFIh|ryP NYTZd5J7W0GQR1XS
NCI-H1623 cell M3LMb2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NF7hWppKdmirYnn0bY9vKG:oIHj1cYFvKE6FST3INVYzOyClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTF3LkC1PVYh|ryP NGPOe2FUSU6JRWK=
NCI-H1648 cell NVT4XJYzT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MnjJTY5pcWKrdHnvckBw\iCqdX3hckBPS0lvSEG2OFgh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF02Njd3NUGg{txO NYq3XHRnW0GQR1XS
NCI-H1650 cell M3nkdGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M1rNNmlvcGmkaYTpc44hd2ZiaIXtZY4hVkOLLVixOlUxKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OTFwNUGzOEDPxE1? M1fzXnNCVkeHUh?=
NCI-H1651 cell NV;aU5JrT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NEHEWlVKdmirYnn0bY9vKG:oIHj1cYFvKE6FST3INVY2OSClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTF4LkSzN|gh|ryP NEXEPVhUSU6JRWK=
NCI-H1703 cell M4rneGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MX7Jcohq[mm2aX;uJI9nKGi3bXHuJG5EUS2KMUewN{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVE2NjV5NzFOwG0> NX\sOHhWW0GQR1XS
NCI-H1734 cell NHHRc5VIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NF7FcpNKdmirYnn0bY9vKG:oIHj1cYFvKE6FST3INVc{PCClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTFyLke3PFgh|ryP NVvTPHRQW0GQR1XS
NCI-H1755 cell MUHHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M4jWcWlvcGmkaYTpc44hd2ZiaIXtZY4hVkOLLVixO|U2KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OS5yNUWzNUDPxE1? NIDpfppUSU6JRWK=
NCI-H1770 cell MmLrS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M1LR[WlvcGmkaYTpc44hd2ZiaIXtZY4hVkOLLVixO|cxKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OzRwMUe5N{DPxE1? NHPseI5USU6JRWK=
NCI-H1792 cell M{fSUmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MkfSTY5pcWKrdHnvckBw\iCqdX3hckBPS0lvSEG3PVIh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0zQS56M{e5JO69VQ>? Ml7jV2FPT0WU
NCI-H1963 cell MlKyS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M{nEcWlvcGmkaYTpc44hd2ZiaIXtZY4hVkOLLVixPVY{KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OTlwN{S5OEDPxE1? NEKxOpBUSU6JRWK=
NCI-H1993 cell M1nDWmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NIjnOYNKdmirYnn0bY9vKG:oIHj1cYFvKE6FST3INVk6OyClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTJ{Lk[xOUDPxE1? MYnTRW5ITVJ?
NCI-H2009 cell NVTOOGxXT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MljDTY5pcWKrdHnvckBw\iCqdX3hckBPS0lvSEKwNFkh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF04NjN7MEG5JO69VQ>? NF\aOpBUSU6JRWK=
NCI-H2030 cell M3fNfGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NXHrTGZ3UW6qaXLpeIlwdiCxZjDoeY1idiCQQ1mtTFIxOzBiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1zLkm0OFg{KM7:TR?= NUCxTYF[W0GQR1XS
NCI-H2122 cell MXnHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MnTKTY5pcWKrdHnvckBw\iCqdX3hckBPS0lvSEKxNlIh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yOC5zM{i1JO69VQ>? M1vtTnNCVkeHUh?=
NCI-H2126 cell MWnHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MV3Jcohq[mm2aX;uJI9nKGi3bXHuJG5EUS2KMkGyOkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEzNjN|N{Gg{txO MnqzV2FPT0WU
NCI-H2170 cell MUfHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M3Ln[GlvcGmkaYTpc44hd2ZiaIXtZY4hVkOLLViyNVcxKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OThwMUCyPEDPxE1? M4e2N3NCVkeHUh?=
NCI-H2196 cell NV\w[VcyT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NX24dnlOUW6qaXLpeIlwdiCxZjDoeY1idiCQQ1mtTFIyQTZiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1{ND64NFA{KM7:TR?= MWTTRW5ITVJ?
NCI-H2228 cell MXnHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MlniTY5pcWKrdHnvckBw\iCqdX3hckBPS0lvSEKyNlgh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0zNjJ6NkC0JO69VQ>? NWCzfJFKW0GQR1XS
NCI-H2342 cell M{XiOmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MmeyTY5pcWKrdHnvckBw\iCqdX3hckBPS0lvSEKzOFIh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0xNjl|N{e5JO69VQ>? NGXMd2tUSU6JRWK=
NCI-H2347 cell M3W3Rmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MmC3TY5pcWKrdHnvckBw\iCqdX3hckBPS0lvSEKzOFch[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yPi5zNUixJO69VQ>? NWLWT25oW0GQR1XS
NCI-H2405 cell M4DVZmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NETLR2FKdmirYnn0bY9vKG:oIHj1cYFvKE6FST3INlQxPSClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTFyLkSyNVIh|ryP M1O2VHNCVkeHUh?=
NCI-H2452 cell NHvEWnZIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NVfy[GFlUW6qaXLpeIlwdiCxZjDoeY1idiCQQ1mtTFI1PTJiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1{Nj62OVk1KM7:TR?= M3zoV3NCVkeHUh?=
NCI-H292 cell M1jzR2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MUHJcohq[mm2aX;uJI9nKGi3bXHuJG5EUS2KMkmyJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Ok4xPDh|NzFOwG0> MlPqV2FPT0WU
NCI-H345 cell NVrDT5N[T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MVTJcohq[mm2aX;uJI9nKGi3bXHuJG5EUS2KM{S1JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NVYvOjdyNjFOwG0> MkexV2FPT0WU
NCI-H358 cell MVTHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NX65dlRlUW6qaXLpeIlwdiCxZjDoeY1idiCQQ1mtTFM2QCClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTF7LkeyN|Mh|ryP NF7UbW9USU6JRWK=
NCI-H460 cell MX3Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M4PXRWlvcGmkaYTpc44hd2ZiaIXtZY4hVkOLLVi0OlAh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF01NjZ{OUmzJO69VQ>? Mn75V2FPT0WU
NCI-H520 cell MoXES5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NH;3XGtKdmirYnn0bY9vKG:oIHj1cYFvKE6FST3IOVIxKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OS5zM{OwN{DPxE1? NGnoT2xUSU6JRWK=
NCI-H522 cell M4LIdGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MliwTY5pcWKrdHnvckBw\iCqdX3hckBPS0lvSEWyNkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEyNjB6N{Sg{txO NYDlZlZQW0GQR1XS
NCI-H526 cell M{TnNGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NV;JOHI1UW6qaXLpeIlwdiCxZjDoeY1idiCQQ1mtTFUzPiClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTJ{Lki4O|PPxE1? MYjTRW5ITVJ?
NCI-H596 NW\CT|hKT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NF63VIpKdmirYnn0bY9vKG:oIHj1cYFvKE6FST3IOVk3KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OTdwNUewPEDPxE1? Mnm2V2FPT0WU
NCI-H630 cell MVXHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NXrvN|ZiUW6qaXLpeIlwdiCxZjDoeY1idiCQQ1mtTFY{OCClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTVwNUGwOVUh|ryP MWnTRW5ITVJ?
NCI-H64 cell NXXXNVI4T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NHWwPGhKdmirYnn0bY9vKG:oIHj1cYFvKE6FST3IOlQh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yOi53NEOxJO69VQ>? NITpUJVUSU6JRWK=
NCI-H650 cell MV;Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M3z1dmlvcGmkaYTpc44hd2ZiaIXtZY4hVkOLLVi2OVAh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF04NjV7OEe3JO69VQ>? NFPpTJFUSU6JRWK=
NCI-H661 cell NHWyb3NIem:5dHigbY5pcWKrdHnvckBie3OjeR?= Mn;0TY5pcWKrdHnvckBw\iCqdX3hckBPS0lvSE[2NUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVUvPDJ|Mk[g{txO M3rZRnNCVkeHUh?=
NCI-H747 cell Mk[xS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NFrvRo5KdmirYnn0bY9vKG:oIHj1cYFvKE6FST3IO|Q4KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:Py54Mke5PUDPxE1? Ml\JV2FPT0WU
NCI-H838 cell NEH5SW5Iem:5dHigbY5pcWKrdHnvckBie3OjeR?= NF:0PYxKdmirYnn0bY9vKG:oIHj1cYFvKE6FST3IPFM5KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OzFwNEGxPEDPxE1? NWDQSWpsW0GQR1XS
NCI-N87 cell Mnm5S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MXHJcohq[mm2aX;uJI9nKGi3bXHuJG5EUS2QOEegZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yPU4{ODR{IN88US=> NUjmVlVHW0GQR1XS
NH-12 cell M2HPOmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NUHrfGZSUW6qaXLpeIlwdiCxZjDoeY1idiCQSD2xNkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVAvPjB6NkSg{txO NVXwfZlpW0GQR1XS
NKM-1 cell Ml;mS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M2nHVGlvcGmkaYTpc44hd2ZiaIXtZY4hVkuPLUGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yMlc2QTJ|IN88US=> M1exVXNCVkeHUh?=
NMC-G1 cell NGrWc2xIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NHraZpJKdmirYnn0bY9vKG:oIHj1cYFvKE6PQz3HNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVQzNjZ4OUOg{txO NIXwemdUSU6JRWK=
NOS-1 cell M2S4Umdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NFPyXnRKdmirYnn0bY9vKG:oIHj1cYFvKE6RUz2xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU4{Pjl3MzFOwG0> Mnf1V2FPT0WU
NUGC-3 cell Ml23S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NF3nboxKdmirYnn0bY9vKG:oIHj1cYFvKE6XR1OtN{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVE3NjV7ME[g{txO Ml3HV2FPT0WU
NY cell MmXES5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NXP1TGFGUW6qaXLpeIlwdiCxZjDoeY1idiCQWTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUOxMlE5PjRizszN MmfnV2FPT0WU
OAW-42 cell NI\t[VJIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NGjOXHZKdmirYnn0bY9vKG:oIHj1cYFvKE:DVz20NkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVcvOzF3NkWg{txO NH7TcFdUSU6JRWK=
OCI-AML2 cell NH73W4pIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M{Ljb2lvcGmkaYTpc44hd2ZiaIXtZY4hV0OLLVHNUFIh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0{Oy5{NUOxJO69VQ>? MUjTRW5ITVJ?
OCUB-M cell MUjHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MYHJcohq[mm2aX;uJI9nKGi3bXHuJG9EXUJvTTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUeuO|IyPTJizszN NHHWOmJUSU6JRWK=
OE19 cell NFT3dZZIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MkHoTY5pcWKrdHnvckBw\iCqdX3hckBQTTF7IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Nz63OlY5PCEQvF2= NY\Wd5Z6W0GQR1XS
OE33 cell NVvkUnBwT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NHL6U4NKdmirYnn0bY9vKG:oIHj1cYFvKE:HM{OgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlg5QTJ4IN88US=> MVTTRW5ITVJ?
OMC-1 cell M13YRmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M3rvZ2lvcGmkaYTpc44hd2ZiaIXtZY4hV02FLUGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME25MlI2ODl6IN88US=> NV3wO|lrW0GQR1XS
OS-RC-2 cell MVXHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MVrJcohq[mm2aX;uJI9nKGi3bXHuJG9UNVKFLUKgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME24MlUzOzB5IN88US=> NYrDNVNXW0GQR1XS
OVCAR-3 cell NIPCZmxIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MmOzTY5pcWKrdHnvckBw\iCqdX3hckBQXkODUj2zJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU45PDRzNTFOwG0> M4TCbnNCVkeHUh?=
OVCAR-4 cell MlfhS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MWHJcohq[mm2aX;uJI9nKGi3bXHuJG9XS0GULUSgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2zNE41PjZizszN MlXNV2FPT0WU
P12-ICHIKAWA cell MWjHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NVL0OI15UW6qaXLpeIlwdiCxZjDoeY1idiCSMUKtTWNJUUuDV1GgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xOE44Pjh|IN88US=> NVHPWoV3W0GQR1XS
P30-OHK cell MVPHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MoPDTY5pcWKrdHnvckBw\iCqdX3hckBROzBvT1jLJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9OE42OzZizszN MXjTRW5ITVJ?
PA-1 cell NInOd2pIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MWPJcohq[mm2aX;uJI9nKGi3bXHuJHBCNTFiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD17LkC3OlE2KM7:TR?= NHvJbGRUSU6JRWK=
PANC-03-27 cell NGrJdHBIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M{jRNmlvcGmkaYTpc44hd2ZiaIXtZY4hWEGQQz2wN{0zPyClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRThwN{GwPFIh|ryP Mkf3V2FPT0WU
PANC-10-05 cell M4XxOWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NYr1W3ZiUW6qaXLpeIlwdiCxZjDoeY1idiCSQV7DMVExNTB3IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MUSuPVk2QSEQvF2= MlX4V2FPT0WU
PC-3 cell MXHHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MXnJcohq[mm2aX;uJI9nKGi3bXHuJHBENTNiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1zMD61NVM2KM7:TR?= NYW3bXFFW0GQR1XS
PF-382 cell Ml7yS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M2rlO2lvcGmkaYTpc44hd2ZiaIXtZY4hWEZvM{iyJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NVEvPjh{ODFOwG0> NILYdVZUSU6JRWK=
RCC10RGB cell Mn35S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MX\Jcohq[mm2aX;uJI9nKGi3bXHuJHJESzFyUlfCJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9PE43PTZ5IN88US=> NVz1dohkW0GQR1XS
RD cell NH;QR|NIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NHLUToRKdmirYnn0bY9vKG:oIHj1cYFvKFKGIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MkCuOlA{PiEQvF2= NFrpVI5USU6JRWK=
REH cell MXrHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MojxTY5pcWKrdHnvckBw\iCqdX3hckBTTUhiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1zMT60PFg{KM7:TR?= NHG2UodUSU6JRWK=
RERF-LC-MS cell MVnHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NVXZe4E2UW6qaXLpeIlwdiCxZjDoeY1idiCURWLGMWxENU2VIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Mk[uNVM1PyEQvF2= MVvTRW5ITVJ?
RKO cell NXG5bZdnT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NYCyS21bUW6qaXLpeIlwdiCxZjDoeY1idiCUS1:gZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xPU41PDN7IN88US=> M4TxbnNCVkeHUh?=
RO82-W-1 cell NEHRTlJIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NXjLd2t[UW6qaXLpeIlwdiCxZjDoeY1idiCUT{iyMXcuOSClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTR5LkK3PFMh|ryP NHvBVlNUSU6JRWK=
RPMI-2650 cell MVLHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M4[2fWlvcGmkaYTpc44hd2ZiaIXtZY4hWlCPST2yOlUxKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:PS55N{m0O{DPxE1? M{XDcnNCVkeHUh?=
RPMI-8402 cell M{jKbmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MVjJcohq[mm2aX;uJI9nKGi3bXHuJHJRVUlvOESwNkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVE3NjN2MzFOwG0> NVzjXHl6W0GQR1XS
RS4-11 cell MlrSS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M1PJdGlvcGmkaYTpc44hd2ZiaIXtZY4hWlN2LUGxJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Ok43QDZ2NTFOwG0> NFrZR5NUSU6JRWK=
RT-112 cell NWfZWYlDT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MnPqTY5pcWKrdHnvckBw\iCqdX3hckBTXC1zMUKgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME22MlcyQTV{IN88US=> NHfY[2VUSU6JRWK=
RVH-421 cell MYTHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NXPje2RWUW6qaXLpeIlwdiCxZjDoeY1idiCUVlitOFIyKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OzJwM{[wOkDPxE1? NETxVY9USU6JRWK=
RXF393 cell Mo\uS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NVzKZ4EyUW6qaXLpeIlwdiCxZjDoeY1idiCUWF[zPVMh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0zOC53OE[zJO69VQ>? MYjTRW5ITVJ?
SBC-5 cell MWLHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MY\Jcohq[mm2aX;uJI9nKGi3bXHuJHNDSy13IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MkCuPFMzPSEQvF2= MVXTRW5ITVJ?
SCC-25 cell NUDUcldIT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M1jKTGlvcGmkaYTpc44hd2ZiaIXtZY4hW0OFLUK1JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NVUvQDF5OTFOwG0> M4C4UnNCVkeHUh?=
SCC-4 cell NEfreGNIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MoL6TY5pcWKrdHnvckBw\iCqdX3hckBUS0NvNDDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUmuOVkzQDNizszN M4PEXHNCVkeHUh?=
SCC-9 cell MXXHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MXLJcohq[mm2aX;uJI9nKGi3bXHuJHNESy17IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Mz6wPFU{PiEQvF2= MYLTRW5ITVJ?
SF126 cell MVPHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NHfyZ21KdmirYnn0bY9vKG:oIHj1cYFvKFOIMUK2JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NVAvPjd2NjFOwG0> NH;le5RUSU6JRWK=
SF268 cell MlT1S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NHGyZnZKdmirYnn0bY9vKG:oIHj1cYFvKFOIMk[4JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NVUvOTN6NzFOwG0> MlzPV2FPT0WU
SF295 cell NXPWPZFCT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MWLJcohq[mm2aX;uJI9nKGi3bXHuJHNHOjl3IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MUOuOlE5OyEQvF2= MUDTRW5ITVJ?
SIG-M5 cell M{PzXGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MXfJcohq[mm2aX;uJI9nKGi3bXHuJHNKTy2PNTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGyMlY3ODRizszN MVnTRW5ITVJ?
SJSA-1 cell M{nmOmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M2X3OGlvcGmkaYTpc44hd2ZiaIXtZY4hW0qVQT2xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9N|YvQTB5MjFOwG0> MWHTRW5ITVJ?
SK-CO-1 cell M{PMfGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M4\p[WlvcGmkaYTpc44hd2ZiaIXtZY4hW0tvQ1:tNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVExNjZ|OUSg{txO MnTLV2FPT0WU
SK-LMS-1 cell NUnYcYt{T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NFPhZ2RKdmirYnn0bY9vKG:oIHj1cYFvKFONLVzNV{0yKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:QC55NkS1NkDPxE1? NHTPTHdUSU6JRWK=
SK-LU-1 cell MkfsS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NVvncYVmUW6qaXLpeIlwdiCxZjDoeY1idiCVSz3MWU0yKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:PDJwMESzJO69VQ>? M2rpUHNCVkeHUh?=
SK-MEL-24 cell MmnMS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NWXFUnd7UW6qaXLpeIlwdiCxZjDoeY1idiCVSz3NSWwuOjRiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1zMz6xOlc2KM7:TR?= MlLxV2FPT0WU
SK-MEL-3 cell MXrHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MUHJcohq[mm2aX;uJI9nKGi3bXHuJHNMNU2HTD2zJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NlEvPDZ7NjFOwG0> M{HnXXNCVkeHUh?=
SK-MES-1 cell MY\Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? Mn3DTY5pcWKrdHnvckBw\iCqdX3hckBUUy2PRWOtNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIvOTByOU[g{txO NWjkSXhRW0GQR1XS
human SN12C cell MnvSS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M1nGSGlvcGmkaYTpc44hd2ZiaIXtZY4hW05zMlOgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xO{4yQTZ5IN88US=> MVHTRW5ITVJ?
SNB75 cell MWPHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NEnFfFdKdmirYnn0bY9vKG:oIHj1cYFvKFOQQke1JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9O{45Ojl5IN88US=> NGHzN5ZUSU6JRWK=
SNU-387 cell MnjUS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NVXxe3dwUW6qaXLpeIlwdiCxZjDoeY1idiCVTmWtN|g4KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:PC5zOUW0OEDPxE1? MVvTRW5ITVJ?
SNU-423 cell NWnrS3ZzT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M3XLTGlvcGmkaYTpc44hd2ZiaIXtZY4hW06XLUSyN{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVUvQTR7M{Og{txO MnTaV2FPT0WU
SNU-C1 cell MofpS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NHn6flRKdmirYnn0bY9vKG:oIHj1cYFvKFOQVT3DNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIvODB7NEig{txO M3LEcnNCVkeHUh?=
SNU-C2B cell NYXBcnpJT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MWnJcohq[mm2aX;uJI9nKGi3bXHuJHNPXS2FMlKgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yNk4zPjd|IN88US=> MX7TRW5ITVJ?
SR cell MmPoS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MW\Jcohq[mm2aX;uJI9nKGi3bXHuJHNTKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OTNwMEe0OkDPxE1? NFPRdYxUSU6JRWK=
SU-DHL-1 cell NE\vUFlIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NGqwdotKdmirYnn0bY9vKG:oIHj1cYFvKFOXLVTIUE0yKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:Pi56MUW0N{DPxE1? NW\sbHc1W0GQR1XS
SW1710 cell M3HLOWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MVnJcohq[mm2aX;uJI9nKGi3bXHuJHNYOTdzMDDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGuN|g5QTJizszN MVfTRW5ITVJ?
SW780 cell MlvhS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MYfJcohq[mm2aX;uJI9nKGi3bXHuJHNYPzhyIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;ND64PVM2QCEQvF2= NVHiSmNyW0GQR1XS
SW872 cell M3Xtdmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MoPLTY5pcWKrdHnvckBw\iCqdX3hckBUXzh5MjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUG0MlE1OzVizszN MWLTRW5ITVJ?
SW954 cell NIHNZ45Iem:5dHigbY5pcWKrdHnvckBie3OjeR?= Mkn3TY5pcWKrdHnvckBw\iCqdX3hckBUXzl3NDDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUWuPFU4QDNizszN MYHTRW5ITVJ?
T47D cell NXSzNYwxT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M3TWeWlvcGmkaYTpc44hd2ZiaIXtZY4hXDR5RDDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUCuOVE3OiEQvF2= NV;FbGZGW0GQR1XS
22RV1 cell NXnRSZpQT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NWLyUHhPUW6qaXLpeIlwdiCxZjDoeY1idiB{MmLWNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVYvPjF2MkSg{txO MnKyV2FPT0WU
23132-87 cell NVO0O4pUT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MX3Jcohq[mm2aX;uJI9nKGi3bXHuJFI{OTN{LUi3JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NE44PTl|ODFOwG0> NEXRbmFUSU6JRWK=
639-V cell MYnHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M3ztbWlvcGmkaYTpc44hd2ZiaIXtZY4hPjN7LW[gZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME21Mlg4PzNizszN MVrTRW5ITVJ?
697 cell MoH4S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MWnJcohq[mm2aX;uJI9nKGi3bXHuJFY6PyClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTdwMUe3OFYh|ryP NUjXNo1uW0GQR1XS
769-P cell M3Ltb2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MULJcohq[mm2aX;uJI9nKGi3bXHuJFc3QS2SIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MT6xNFQ5OyEQvF2= Mk\FV2FPT0WU
8-MG-BA cell M2XONGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MnfETY5pcWKrdHnvckBw\iCqdX3hckA5NU2JLVLBJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9PE43OzRyMTFOwG0> NH22OnhUSU6JRWK=
A4-Fuk cell MXLHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MnXoTY5pcWKrdHnvckBw\iCqdX3hckBCPC2IdXugZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlg2QDNizszN MYjTRW5ITVJ?
A427 cell NEjVZ5dIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MnnGTY5pcWKrdHnvckBw\iCqdX3hckBCPDJ5IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Mz6wO|Y6OyEQvF2= NGPnfmhUSU6JRWK=
A498 cell NUHiVpRlT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NGK4c|dKdmirYnn0bY9vKG:oIHj1cYFvKEF2OUigZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlA5OTN2IN88US=> MV\TRW5ITVJ?
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... Click to View More Cell Line Experimental Data

In vivo In mice, Akti-1/2 (50 mg/kg, i.p.) inhibits basal and IGF-stimulated Akt1 and Akt2 phosphorylation in lung. [1]

Protocol

Kinase Assay:[2]
+ Expand

Kinase screen:

Briefly, all assays (25.5 μl at 21°C for 30 min) are performed using a Biomek 2000 Laboratory Automation Workstation in a 96-well format. Reactions contains 5–20 mU purified kinase along with substrate peptide or protein and are initiated by the addition of 10 mM MgAcetate and 5, 20, or 50 μM ATP ([γ-33P]-ATP, 800 cpm/pmol).
Cell Research:[4 ]
+ Expand
  • Cell lines: HCC827, NCI-H522, NCI-1651, and PC-9 cells
  • Concentrations: ~10 μM
  • Incubation Time: 96 h
  • Method: The cell growth inhibitory effect of AKTi-1/2 is studied using the 96 h sulforhodamine B assay (SRB). Drug concentrations that inhibited 50% of cell growth (IC50) are calculated for each compound in GraphPad Prism 6.0 using non-linear regression analysis and sigmoidal dose–response (variable slope) equation.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 22 mg/mL (39.88 mM)
Water Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 551.64
Formula

C34H29N7O

CAS No. 612847-09-3
Storage powder
Synonyms Akt Inhibitor VIII

Bio Calculators

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Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

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