Akti-1/2

Catalog No.S7776 Synonyms: Akt Inhibitor VIII

Akti-1/2 Chemical Structure

Molecular Weight(MW): 551.64

Akti-1/2 is a highly selective Akt1/Akt2 inhibitor with IC50 of 58 nM/210 nM, respectively, about 36-fold selectivity for Akt1 over Akt3.

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  • AKTi-1/2 inhibits human HCC cells in vitro. Human HCC HepG2 cells (A–F), Huh-7 cells (G), primary human HCC cells (“Pri HCC”, G) or the primary liver cells (“Pri liver cells”, G) were treated with/out applied concentrations of AKTi-1/2 for indicated time; Cell survival (A, B and G), proliferation (C and D) and apoptosis (E and F) were tested by the listed assays. Data were shown as the mean (n = 5) with the standard deviation (SD). Experiments in this figure were repeated three times, with similar results were obtained. *P < 0.05 vs. “C” (untreated control) group.

    Biochem Biophys Res Commun, 2016, 480(3):334-340. Akti-1/2 purchased from Selleck.

    Autophagy inhibitors sensitize AKTi-1/2-induced cytotoxicity against HCC cells. HepG2 cells were treated with/out AKTi-1/2 (5/10 μM) for indicated time; Listed proteins were tested by Western blot assay (A); The percentage of LC3B-II GFP puncta positive cells ("autophagic cells") was calculated (B). HepG2 cells, pretreated with 3-methyladenine (“3 MA”, 10 mM), ammonium chloride (“NH4Cl”, 1 mM) or bafilomycin A1 (“BafA1”, 1 μM) for 1 h, were treated with AKTi-1/2 (10 μM) for applied time; Cell survival (CCK-8 assay, C) were tested. The IC50 was also determined (D).

    Biochem Biophys Res Commun, 2016, 480(3):334-340.. Akti-1/2 purchased from Selleck.

Purity & Quality Control

Choose Selective Akt Inhibitors

Biological Activity

Description Akti-1/2 is a highly selective Akt1/Akt2 inhibitor with IC50 of 58 nM/210 nM, respectively, about 36-fold selectivity for Akt1 over Akt3.
Targets
Akt1 [1]
(Cell-free assay)
Akt2 [1]
(Cell-free assay)
Akt3 [1]
(Cell-free assay)
58 nM 210 nM 2119 nM
In vitro

In a cell-based IPKA (C33A) assay, Akti-1/2 inhibits Akt1 and Akt2 with IC50 of 305 nM and 2086 nM, respectively. In HT29, MCF7, and A2780 cells, Akti-1/2 induces cell apoptosis by dramatically increasing caspase-3 activity. [1] In liver cells, Akti-1/2 blocks insulin regulation of PEPCK, G6Pase expression, and FOXO1 activity. [2] Akti-1/2 also strongly potentiates PAR-1-mediated platelet aggregation by blocking PKB. [3] In HCC827, NCI-H522, NCI-1651, and PC-9 cells, Akti-1/2 inhibits cell growth with IC50 of 4.7 μM, 7.25 μM, and 9.5 μM, when in combination with gefitinib, Akti-1/2 causes enhanced inhibition of cell growth and apoptosis. [4]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
MDA-MB-468 cells NWK0Z5JLS3m2b4TvfIlkcXS7IHHzd4F6 NWG5VFRnOTBizszN M1j6fmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG1FSS2PQj20Olgh[2WubIOgbY4heHKnc3XuZ4Uhd2ZiMUCgeW0h[2iub4LvdZVqdmViYomgV3JDKGG|c3H5MEBIUTVyPUKuOlYh|ryP MmTSNVg3QTF6OUS=
MDA-MB-231 cells MYXDfZRwfG:6aXPpeJkh[XO|YYm= NELQTWkyOCEQvF2= NHHRVVBEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBOTEFvTVKtNlMyKGOnbHzzJIlvKHC{ZYPlcoNmKG:oIEGwJJVOKGOqbH;yc5F2cW6nIHL5JHNTSiCjc4PhfUwhT0l3ME20MlU2KM7:TR?= MYGxPFY6OTh7NB?=
MCF7 cells NGnhc5NEgXSxdH;4bYNqfHliYYPzZZk> NVPoZ2dJOTBizszN M1PVWWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG1ETjdiY3XscJMhcW5icILld4Vv[2Vib3[gNVAhfU1iY3jsc5JweXWrbnWgZpkhW1KEIHHzd4F6NCCJSUWwQVAvPDFizszN MnHwNVg3QTF6OUS=
184B5 cells NE\nd3dEgXSxdH;4bYNqfHliYYPzZZk> M1S1WFIxKM7:TR?= MnrWR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gNVg1SjViY3XscJMh[XRiMkCgeW0h[2iub4LvdZVqdmViYomgV3JDKGG|c3H5MEBIUTVyPUK1Mlc3KM7:TR?= M4rFeVE5PjlzOEm0
NCI-H1563 cell NFXuOIhIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NFrBbIlKdmirYnn0bY9vKG:oIHj1cYFvKE6FST3INVU3OyClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTBwNUSyOFYh|ryP MWrTRW5ITVJ?
NCI-H1618 cel NIjqUY9Iem:5dHigbY5pcWKrdHnvckBie3OjeR?= M{HnU2lvcGmkaYTpc44hd2ZiaIXtZY4hVkOLLVixOlE5KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OjFwOUm4NkDPxE1? MXTTRW5ITVJ?
NCI-H1623 cell MlHyS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M{jvR2lvcGmkaYTpc44hd2ZiaIXtZY4hVkOLLVixOlI{KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OTVwMEW5OkDPxE1? M{P6WXNCVkeHUh?=
NCI-H1648 cell NV74bJNST3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M4q4WmlvcGmkaYTpc44hd2ZiaIXtZY4hVkOLLVixOlQ5KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:PS55NUWxJO69VQ>? MUnTRW5ITVJ?
NCI-H1650 cell MnzJS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MmjiTY5pcWKrdHnvckBw\iCqdX3hckBPS0lvSEG2OVAh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yOS53MUO0JO69VQ>? NW\Bc5VjW0GQR1XS
NCI-H1651 cell NUHZPWt3T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NWrwNWZ6UW6qaXLpeIlwdiCxZjDoeY1idiCQQ1mtTFE3PTFiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1zNj60N|M5KM7:TR?= NHrJRoVUSU6JRWK=
NCI-H1703 cell NGWw[|VIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M1XnPWlvcGmkaYTpc44hd2ZiaIXtZY4hVkOLLVixO|A{KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OTVwNUe3JO69VQ>? M2G5dnNCVkeHUh?=
NCI-H1734 cell NF31SplIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MVzJcohq[mm2aX;uJI9nKGi3bXHuJG5EUS2KMUezOEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVExNjd5OEig{txO NF[3Wm5USU6JRWK=
NCI-H1755 cell MmfpS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MkLLTY5pcWKrdHnvckBw\iCqdX3hckBPS0lvSEG3OVUh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yNjB3NUOxJO69VQ>? MlXLV2FPT0WU
NCI-H1770 cell M4q5[Gdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M1ezUmlvcGmkaYTpc44hd2ZiaIXtZY4hVkOLLVixO|cxKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OzRwMUe5N{DPxE1? NWHmbmVjW0GQR1XS
NCI-H1792 cell M{G4UWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MV3Jcohq[mm2aX;uJI9nKGi3bXHuJG5EUS2KMUe5NkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVI6Njh|N{mg{txO MYTTRW5ITVJ?
NCI-H1963 cell MmDXS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? Mn[yTY5pcWKrdHnvckBw\iCqdX3hckBPS0lvSEG5OlMh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yQS55NEm0JO69VQ>? M1f2fXNCVkeHUh?=
NCI-H1993 cell M3r6dGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M4jJOmlvcGmkaYTpc44hd2ZiaIXtZY4hVkOLLVixPVk{KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OjJwNkG1JO69VQ>? NWqweI52W0GQR1XS
NCI-H2009 cell MnzJS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MlTpTY5pcWKrdHnvckBw\iCqdX3hckBPS0lvSEKwNFkh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF04NjN7MEG5JO69VQ>? MWXTRW5ITVJ?
NCI-H2030 cell MkHhS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M1nRVmlvcGmkaYTpc44hd2ZiaIXtZY4hVkOLLViyNFMxKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OS57NES4N{DPxE1? NULNTnZ[W0GQR1XS
NCI-H2122 cell NGfRW3dIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NVi0fZlMUW6qaXLpeIlwdiCxZjDoeY1idiCQQ1mtTFIyOjJiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1zMD6xN|g2KM7:TR?= NFW3U|FUSU6JRWK=
NCI-H2126 cell NFGwcm1Iem:5dHigbY5pcWKrdHnvckBie3OjeR?= NW\oTWw5UW6qaXLpeIlwdiCxZjDoeY1idiCQQ1mtTFIyOjZiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1zMj6zN|cyKM7:TR?= M3HJWXNCVkeHUh?=
NCI-H2170 cell NXuwToZVT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MWPJcohq[mm2aX;uJI9nKGi3bXHuJG5EUS2KMkG3NEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVE5NjFyMkig{txO NF3hXGhUSU6JRWK=
NCI-H2196 cell MmXHS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MojxTY5pcWKrdHnvckBw\iCqdX3hckBPS0lvSEKxPVYh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0zPC56MECzJO69VQ>? MnPpV2FPT0WU
NCI-H2228 cell M4jvZ2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NFGwXHlKdmirYnn0bY9vKG:oIHj1cYFvKE6FST3INlIzQCClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTJwMki2NFQh|ryP MYjTRW5ITVJ?
NCI-H2342 cell MUjHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? Moi3TY5pcWKrdHnvckBw\iCqdX3hckBPS0lvSEKzOFIh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0xNjl|N{e5JO69VQ>? NWPIcFhzW0GQR1XS
NCI-H2347 cell NFLDTYRIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MXTJcohq[mm2aX;uJI9nKGi3bXHuJG5EUS2KMkO0O{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVE3NjF3OEGg{txO NX:zdpczW0GQR1XS
NCI-H2405 cell NU\6WJFsT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MlK4TY5pcWKrdHnvckBw\iCqdX3hckBPS0lvSEK0NFUh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yOC52MkGyJO69VQ>? MnLSV2FPT0WU
NCI-H2452 cell NUK2OlZOT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MlzBTY5pcWKrdHnvckBw\iCqdX3hckBPS0lvSEK0OVIh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0zPi54NUm0JO69VQ>? M{H0OHNCVkeHUh?=
NCI-H292 cell M1S2T2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NE\DT5FKdmirYnn0bY9vKG:oIHj1cYFvKE6FST3INlkzKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:Pi5yNEizO{DPxE1? NI[3U|dUSU6JRWK=
NCI-H345 cell NXG4VGRoT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MULJcohq[mm2aX;uJI9nKGi3bXHuJG5EUS2KM{S1JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NVYvOjdyNjFOwG0> NEXqV4dUSU6JRWK=
NCI-H358 cell MmLxS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MXLJcohq[mm2aX;uJI9nKGi3bXHuJG5EUS2KM{W4JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NVkvPzJ|MzFOwG0> MWLTRW5ITVJ?
NCI-H460 cell NVHpempoT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MYPJcohq[mm2aX;uJI9nKGi3bXHuJG5EUS2KNE[wJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9OE43Ojl7MzFOwG0> M{j2[HNCVkeHUh?=
NCI-H520 cell NITxb4NIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NE\qcWpKdmirYnn0bY9vKG:oIHj1cYFvKE6FST3IOVIxKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OS5zM{OwN{DPxE1? MV3TRW5ITVJ?
NCI-H522 cell MljBS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NH3pdmhKdmirYnn0bY9vKG:oIHj1cYFvKE6FST3IOVIzKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OTFwMEi3OEDPxE1? M2q5O3NCVkeHUh?=
NCI-H526 cell MmP2S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M3LBWWlvcGmkaYTpc44hd2ZiaIXtZY4hVkOLLVi1NlYh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0zOi56OEez{txO MWrTRW5ITVJ?
NCI-H596 MYDHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NGjUfZNKdmirYnn0bY9vKG:oIHj1cYFvKE6FST3IOVk3KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OTdwNUewPEDPxE1? MX3TRW5ITVJ?
NCI-H630 cell MlrRS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MmrHTY5pcWKrdHnvckBw\iCqdX3hckBPS0lvSE[zNEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVUvPTFyNUWg{txO NIOxfJVUSU6JRWK=
NCI-H64 cell NF7jR4FIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M4TWO2lvcGmkaYTpc44hd2ZiaIXtZY4hVkOLLVi2OEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEzNjV2M{Gg{txO MVHTRW5ITVJ?
NCI-H650 cell MorxS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NGTWfWZKdmirYnn0bY9vKG:oIHj1cYFvKE6FST3IOlUxKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:Py53OUi3O{DPxE1? Mmf6V2FPT0WU
NCI-H661 cell Mn;rS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MYLJcohq[mm2aX;uJI9nKGi3bXHuJG5EUS2KNk[xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9OU41OjN{NjFOwG0> NWKxc4htW0GQR1XS
NCI-H747 cell MVfHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MnO4TY5pcWKrdHnvckBw\iCqdX3hckBPS0lvSEe0O{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVcvPjJ5OUmg{txO MmrJV2FPT0WU
NCI-H838 cell MUPHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MVjJcohq[mm2aX;uJI9nKGi3bXHuJG5EUS2KOEO4JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9N|EvPDFzODFOwG0> NIr5RZdUSU6JRWK=
NCI-N87 cell NWjWRWpDT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MlPzTY5pcWKrdHnvckBw\iCqdX3hckBPS0lvTki3JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NlkvOzB2MjFOwG0> NV35Z2FpW0GQR1XS
NH-12 cell MnK2S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? Mm\yTY5pcWKrdHnvckBw\iCqdX3hckBPUC1zMjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUCuOlA5PjRizszN NGTPSFVUSU6JRWK=
NKM-1 cell NHnQdoRIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NYiybpp{UW6qaXLpeIlwdiCxZjDoeY1idiCQS12tNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIvPzV7MkOg{txO M2XGdXNCVkeHUh?=
NMC-G1 cell NETid4lIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MYTJcohq[mm2aX;uJI9nKGi3bXHuJG5OSy2JMTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUSyMlY3QTNizszN MmiyV2FPT0WU
NOS-1 cell MkXlS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NHXEVIdKdmirYnn0bY9vKG:oIHj1cYFvKE6RUz2xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU4{Pjl3MzFOwG0> NGXnVmtUSU6JRWK=
NUGC-3 cell MoDsS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NVfm[np6UW6qaXLpeIlwdiCxZjDoeY1idiCQVVfDMVMh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yPi53OUC2JO69VQ>? NXTqcHZQW0GQR1XS
NY cell NX\hWIhTT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NXLXXVBiUW6qaXLpeIlwdiCxZjDoeY1idiCQWTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUOxMlE5PjRizszN MkXTV2FPT0WU
OAW-42 cell MkPjS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MmTHTY5pcWKrdHnvckBw\iCqdX3hckBQSVdvNEKgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME23MlMyPTZ3IN88US=> MonzV2FPT0WU
OCI-AML2 cell NUHvc5RLT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MUTJcohq[mm2aX;uJI9nKGi3bXHuJG9EUS2DTVyyJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9N|MvOjV|MTFOwG0> NY\zcXR6W0GQR1XS
OCUB-M cell M{\kWWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NFjvPJpKdmirYnn0bY9vKG:oIHj1cYFvKE:FVVKtUUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVcvPzJzNUKg{txO MW\TRW5ITVJ?
OE19 cell MlnzS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MlvhTY5pcWKrdHnvckBw\iCqdX3hckBQTTF7IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Nz63OlY5PCEQvF2= M3;tU3NCVkeHUh?=
OE33 cell MkSzS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M1;BOGlvcGmkaYTpc44hd2ZiaIXtZY4hV0V|MzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGuPFg6OjZizszN NVLkfnhkW0GQR1XS
OMC-1 cell MVXHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NFHDRldKdmirYnn0bY9vKG:oIHj1cYFvKE:PQz2xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9PU4zPTB7ODFOwG0> M2SxfnNCVkeHUh?=
OS-RC-2 cell NFrWbmVIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M4j0SGlvcGmkaYTpc44hd2ZiaIXtZY4hV1NvUlOtNkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVgvPTJ|MEeg{txO MXXTRW5ITVJ?
OVCAR-3 cell MYDHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M3jaeWlvcGmkaYTpc44hd2ZiaIXtZY4hV1[FQWKtN{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEvQDR2MUWg{txO NH\yNHpUSU6JRWK=
OVCAR-4 cell M3PISWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MkL3TY5pcWKrdHnvckBw\iCqdX3hckBQXkODUj20JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9N|AvPDZ4IN88US=> M4TP[HNCVkeHUh?=
P12-ICHIKAWA cell NV3Rd5NZT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MX3Jcohq[mm2aX;uJI9nKGi3bXHuJHAyOi2LQ1jJT2FYSSClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTF2Lke2PFMh|ryP NYLURXAyW0GQR1XS
P30-OHK cell NGP0bGtIem:5dHigbY5pcWKrdHnvckBie3OjeR?= Mnn3TY5pcWKrdHnvckBw\iCqdX3hckBROzBvT1jLJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9OE42OzZizszN MV7TRW5ITVJ?
PA-1 cell MkTVS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MmP4TY5pcWKrdHnvckBw\iCqdX3hckBRSS1zIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;OT6wO|YyPSEQvF2= MoPsV2FPT0WU
PANC-03-27 cell MUnHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M17Rd2lvcGmkaYTpc44hd2ZiaIXtZY4hWEGQQz2wN{0zPyClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRThwN{GwPFIh|ryP MUfTRW5ITVJ?
PANC-10-05 cell NHXHU|RIem:5dHigbY5pcWKrdHnvckBie3OjeR?= Mlv4TY5pcWKrdHnvckBw\iCqdX3hckBRSU6FLUGwMVA2KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OTRwOUm1PUDPxE1? NGHnZXNUSU6JRWK=
PC-3 cell NUPabpZHT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M3PlVmlvcGmkaYTpc44hd2ZiaIXtZY4hWENvMzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGwMlUyOzVizszN NYHV[VZHW0GQR1XS
PF-382 cell MnuxS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MUfJcohq[mm2aX;uJI9nKGi3bXHuJHBHNTN6MjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGxMlY5OjhizszN MlfWV2FPT0WU
RCC10RGB cell M1fROmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NG\xNG9KdmirYnn0bY9vKG:oIHj1cYFvKFKFQ{GwVmdDKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:QC54NU[3JO69VQ>? M1vDeHNCVkeHUh?=
RD cell MX3Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MYHJcohq[mm2aX;uJI9nKGi3bXHuJHJFKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OjBwNkCzOkDPxE1? NIjZVmRUSU6JRWK=
REH cell NVLuVHJpT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MV7Jcohq[mm2aX;uJI9nKGi3bXHuJHJGUCClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTFzLkS4PFMh|ryP MXrTRW5ITVJ?
RERF-LC-MS cell MXXHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MojMTY5pcWKrdHnvckBw\iCqdX3hckBTTVKILVzDMW1UKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OjZwMUO0O{DPxE1? MVnTRW5ITVJ?
RKO cell M4XsTWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NWHJPZQ4UW6qaXLpeIlwdiCxZjDoeY1idiCUS1:gZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xPU41PDN7IN88US=> NHXVZ2hUSU6JRWK=
RO82-W-1 cell MkL2S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NWewfnZXUW6qaXLpeIlwdiCxZjDoeY1idiCUT{iyMXcuOSClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTR5LkK3PFMh|ryP MY\TRW5ITVJ?
RPMI-2650 cell MoPRS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MlLITY5pcWKrdHnvckBw\iCqdX3hckBTWE2LLUK2OVAh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF02Njd5OUS3JO69VQ>? MX7TRW5ITVJ?
RPMI-8402 cell NEj1OHdIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M2LVU2lvcGmkaYTpc44hd2ZiaIXtZY4hWlCPST24OFAzKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OTZwM{SzJO69VQ>? NX\VNG1TW0GQR1XS
RS4-11 cell MkXCS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NXXRc29WUW6qaXLpeIlwdiCxZjDoeY1idiCUU{StNVEh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF03NjZ6NkS1JO69VQ>? NVHJdmlQW0GQR1XS
RT-112 cell NEizRlhIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NIq1RY9KdmirYnn0bY9vKG:oIHj1cYFvKFKWLUGxNkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVYvPzF7NUKg{txO NEjJO3lUSU6JRWK=
RVH-421 cell NFTBfXlIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NXftUWJiUW6qaXLpeIlwdiCxZjDoeY1idiCUVlitOFIyKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OzJwM{[wOkDPxE1? MlPiV2FPT0WU
RXF393 cell NGLJ[WpIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NIDRS4NKdmirYnn0bY9vKG:oIHj1cYFvKFK[RkO5N{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIxNjV6NkOg{txO M3PnSXNCVkeHUh?=
SBC-5 cell M3rEbWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NGfpXoFKdmirYnn0bY9vKG:oIHj1cYFvKFOEQz21JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NlAvQDN{NTFOwG0> MnfGV2FPT0WU
SCC-25 cell M{nVVWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NWTjR2tNUW6qaXLpeIlwdiCxZjDoeY1idiCVQ1OtNlUh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yPS56MUe5JO69VQ>? NVn0b45DW0GQR1XS
SCC-4 cell NXjEcm9lT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M3\Ob2lvcGmkaYTpc44hd2ZiaIXtZY4hW0OFLUSgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME25MlU6Ojh|IN88US=> M1vKT3NCVkeHUh?=
SCC-9 cell NGrhTlhIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MYDJcohq[mm2aX;uJI9nKGi3bXHuJHNESy17IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Mz6wPFU{PiEQvF2= NGC5[nZUSU6JRWK=
SF126 cell MlLiS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NYfD[lR5UW6qaXLpeIlwdiCxZjDoeY1idiCVRkGyOkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVExNjZ5NE[g{txO MlvxV2FPT0WU
SF268 cell MnfqS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MX;Jcohq[mm2aX;uJI9nKGi3bXHuJHNHOjZ6IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MUWuNVM5PyEQvF2= MUTTRW5ITVJ?
SF295 cell MorKS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NIL3eoZKdmirYnn0bY9vKG:oIHj1cYFvKFOIMkm1JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NVMvPjF6MzFOwG0> MWfTRW5ITVJ?
SIG-M5 cell Mnf4S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MYPJcohq[mm2aX;uJI9nKGi3bXHuJHNKTy2PNTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGyMlY3ODRizszN MVHTRW5ITVJ?
SJSA-1 cell NHrXW21Iem:5dHigbY5pcWKrdHnvckBie3OjeR?= M{[5S2lvcGmkaYTpc44hd2ZiaIXtZY4hW0qVQT2xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9N|YvQTB5MjFOwG0> NYP5d3YyW0GQR1XS
SK-CO-1 cell NIDjTWpIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MVLJcohq[mm2aX;uJI9nKGi3bXHuJHNMNUORLUGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xNE43Ozl2IN88US=> MnrzV2FPT0WU
SK-LMS-1 cell MWjHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NFPYVpVKdmirYnn0bY9vKG:oIHj1cYFvKFONLVzNV{0yKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:QC55NkS1NkDPxE1? NFWySpBUSU6JRWK=
SK-LU-1 cell M{Xx[2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NHTwdIJKdmirYnn0bY9vKG:oIHj1cYFvKFONLVzVMVEh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF01Oi5yNEOg{txO M4TrO3NCVkeHUh?=
SK-MEL-24 cell MkjxS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MXHJcohq[mm2aX;uJI9nKGi3bXHuJHNMNU2HTD2yOEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVE{NjF4N{Wg{txO MVzTRW5ITVJ?
SK-MEL-3 cell M2exbGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NEXjW3hKdmirYnn0bY9vKG:oIHj1cYFvKFONLV3FUE0{KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OjFwNE[5OkDPxE1? MWTTRW5ITVJ?
SK-MES-1 cell NYn1bXI2T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M3HadmlvcGmkaYTpc44hd2ZiaIXtZY4hW0tvTVXTMVEh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0zNjFyMEm2JO69VQ>? NUDzcIVrW0GQR1XS
human SN12C cell NFPwNYFIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MmjZTY5pcWKrdHnvckBw\iCqdX3hckBUVjF{QzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUG3MlE6PjdizszN M1jpXXNCVkeHUh?=
SNB75 cell NVr0VIFrT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MWfJcohq[mm2aX;uJI9nKGi3bXHuJHNPSjd3IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Nz64Nlk4KM7:TR?= MWrTRW5ITVJ?
SNU-387 cell MlLpS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MlTNTY5pcWKrdHnvckBw\iCqdX3hckBUVlVvM{i3JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9OE4yQTV2NDFOwG0> NIDhcI5USU6JRWK=
SNU-423 cell M{jQdmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NEDoelJKdmirYnn0bY9vKG:oIHj1cYFvKFOQVT20NlMh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF02Njl2OUOzJO69VQ>? NXTRe4N[W0GQR1XS
SNU-C1 cell MYnHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M1jESGlvcGmkaYTpc44hd2ZiaIXtZY4hW06XLVOxJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Nk4xODl2ODFOwG0> MYjTRW5ITVJ?
SNU-C2B cell NUO3OowxT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M3rlUmlvcGmkaYTpc44hd2ZiaIXtZY4hW06XLVOyRkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIzNjJ4N{Og{txO Ml;4V2FPT0WU
SR cell M{HMbmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NIDsOotKdmirYnn0bY9vKG:oIHj1cYFvKFOUIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MUOuNFc1PiEQvF2= MUPTRW5ITVJ?
SU-DHL-1 cell Mn7aS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NYTqVWN[UW6qaXLpeIlwdiCxZjDoeY1idiCVVT3ETGwuOSClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTZwOEG1OFMh|ryP MXjTRW5ITVJ?
SW1710 cell NGDJW29Iem:5dHigbY5pcWKrdHnvckBie3OjeR?= NUnSVItYUW6qaXLpeIlwdiCxZjDoeY1idiCVV{G3NVAh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yNjN6OEmyJO69VQ>? MVTTRW5ITVJ?
SW780 cell M1myVmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MojMTY5pcWKrdHnvckBw\iCqdX3hckBUXzd6MDDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUSuPFk{PThizszN NHzw[5RUSU6JRWK=
SW872 cell NX\Mb5ZsT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MkTyTY5pcWKrdHnvckBw\iCqdX3hckBUXzh5MjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUG0MlE1OzVizszN MmHRV2FPT0WU
SW954 cell M1nVO2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MUXJcohq[mm2aX;uJI9nKGi3bXHuJHNYQTV2IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;NT64OVc5OyEQvF2= NF[2RoxUSU6JRWK=
T47D cell M1TScmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M1u2ZWlvcGmkaYTpc44hd2ZiaIXtZY4hXDR5RDDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUCuOVE3OiEQvF2= MmnsV2FPT0WU
22RV1 cell NUjFUFhsT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M1nRRmlvcGmkaYTpc44hd2ZiaIXtZY4hOjKUVkGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME22MlYyPDJ2IN88US=> MYHTRW5ITVJ?
23132-87 cell NVjoUHlWT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NGCwOpRKdmirYnn0bY9vKG:oIHj1cYFvKDJ|MUOyMVg4KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OC55NUmzPEDPxE1? MVLTRW5ITVJ?
639-V cell NVzlRYFwT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NXLYdWtnUW6qaXLpeIlwdiCxZjDoeY1idiB4M{mtWkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVUvQDd5MzFOwG0> NIjGTYFUSU6JRWK=
697 cell NGT6dFNIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MnLwTY5pcWKrdHnvckBw\iCqdX3hckA3QTdiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD15LkG3O|Q3KM7:TR?= NUDjZ4dvW0GQR1XS
769-P cell MXjHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MUXJcohq[mm2aX;uJI9nKGi3bXHuJFc3QS2SIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MT6xNFQ5OyEQvF2= NWLETHRZW0GQR1XS
8-MG-BA cell M1;nTWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M3jQbGlvcGmkaYTpc44hd2ZiaIXtZY4hQC2PRz3CRUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVgvPjN2MEGg{txO M4rUNHNCVkeHUh?=
A4-Fuk cell MkjVS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? Mk[1TY5pcWKrdHnvckBw\iCqdX3hckBCPC2IdXugZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlg2QDNizszN NEfTSGNUSU6JRWK=
A427 cell NGPqPXdIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MV\Jcohq[mm2aX;uJI9nKGi3bXHuJGE1OjdiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1|LkC3Olk{KM7:TR?= MmHGV2FPT0WU
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... Click to View More Cell Line Experimental Data

In vivo In mice, Akti-1/2 (50 mg/kg, i.p.) inhibits basal and IGF-stimulated Akt1 and Akt2 phosphorylation in lung. [1]

Protocol

Kinase Assay:[2]
+ Expand

Kinase screen:

Briefly, all assays (25.5 μl at 21°C for 30 min) are performed using a Biomek 2000 Laboratory Automation Workstation in a 96-well format. Reactions contains 5–20 mU purified kinase along with substrate peptide or protein and are initiated by the addition of 10 mM MgAcetate and 5, 20, or 50 μM ATP ([γ-33P]-ATP, 800 cpm/pmol).
Cell Research:[4 ]
+ Expand
  • Cell lines: HCC827, NCI-H522, NCI-1651, and PC-9 cells
  • Concentrations: ~10 μM
  • Incubation Time: 96 h
  • Method: The cell growth inhibitory effect of AKTi-1/2 is studied using the 96 h sulforhodamine B assay (SRB). Drug concentrations that inhibited 50% of cell growth (IC50) are calculated for each compound in GraphPad Prism 6.0 using non-linear regression analysis and sigmoidal dose–response (variable slope) equation.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 22 mg/mL (39.88 mM)
Water Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 551.64
Formula

C34H29N7O

CAS No. 612847-09-3
Storage powder
Synonyms Akt Inhibitor VIII

Bio Calculators

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Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

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