Pazopanib HCl (GW786034 HCl)

Catalog No.S1035

Pazopanib HCl (GW786034 HCl) Chemical Structure

Molecular Weight(MW): 473.98

Pazopanib HCl (GW786034 HCl) is a novel multi-target inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFR, FGFR, c-Kit and c-Fms with IC50 of 10 nM, 30 nM, 47 nM, 84 nM, 74 nM, 140 nM and 146 nM in cell-free assays, respectively.

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In DMSO USD 191 In stock
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3 Customer Reviews

  • IC50 of Pazopanib that block ANDV-induced EC permeability. Endothelial cells were ANDV infected, and 3 days postinfection the permeability of cells in response to VEGF addition was determined in the presence or absence of increasing amounts of kinase inhibitor. (B): VEGFR2-Src inhibitors block ANDV-induced permeability. Endothelial cells were plated on vitronectin-coated Transwell inserts and infected at an MOI of 0.5 in triplicate with ANDV. Three days postinfection, the permeability of ANDV- and mock-infected endothelial cell monolayers was determined at indicated times in the presence or absence of Pazopanib.

    J Virol, 2011, 85(5): 2296-303. Pazopanib HCl (GW786034 HCl) purchased from Selleck.

    MRC5 non-transformed human lung fibroblasts were infected with influenza viruses (100 multiplicity of infection). Two hours after infection the cells were treated with vehicle control; sorafenib tosylate (2mM); pazopanib (2mM); OSU-03012 (2mM); and AR-13 (2mM). Twenty-four hours after infection the cells are treated with live/dead agent where green cells are viable and cells staining yellow or red are considered dead. Cells are examined at 10 magnification in a Hermes wide-field microscope (n¼3 SEM) P<0.05 less than vehicle control level of virus-mediated cell killing.

    J Cell Physiol, 2016, 231(10):2286-302.. Pazopanib HCl (GW786034 HCl) purchased from Selleck.

  • Effect of HDIL-2/TKI on apoptosis of RCC cells. Three RCC cell lines treated with different concentrations of Pazopanib and HDIL-2 and incubated for 48 h. Microscopic images show apoptotic materials 48 h following treatment (arrows show the apoptotic materials in the pazopanib-treated cells).

    Expert Opin Pharmacother 2014 15(11), 1489-99. Pazopanib HCl (GW786034 HCl) purchased from Selleck.

Purity & Quality Control

Choose Selective VEGFR Inhibitors

Biological Activity

Description Pazopanib HCl (GW786034 HCl) is a novel multi-target inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFR, FGFR, c-Kit and c-Fms with IC50 of 10 nM, 30 nM, 47 nM, 84 nM, 74 nM, 140 nM and 146 nM in cell-free assays, respectively.
Features A multi-kinase inhibitor.
Targets
VEGFR1 [1]
(Cell-free assay)
VEGFR2 [1]
(Cell-free assay)
VEGFR3 [1]
(Cell-free assay)
FGFR [1]
(Cell-free assay)
PDGFR [1]
(Cell-free assay)
10 nM 30 nM 47 nM 74 nM 84 nM
In vitro

Pazopanib potently inhibits VEGF-induced phosphorylation of VEGFR2 in HUVEC cells with IC50 of 8 nM. [1] Pazopanib shows dose-dependent growth inhibition in all synovial sarcoma cell lines including SYO-1 and HS-SY-II cells. Proliferation of SYO-1 and HS-SY-II cells is inhibited even at 1 µg/mL of Pazopanib and is completely abolished at 5 µg/mL. Pazopanib induces G1 arrest, and thereby suppresses the growth of synovial sarcoma cells. Phosphorylation of Akts, GSK-3β, JNKs, p70 S6 Kinase, and mTOR is suppressed in Pazopanib-treated SYO-1 cells compared with that in the vehicle-treated cells. [2] Pazopanib between 20 m g/mL and 22.5 m g/mL shows an increasing reduction of RPE cell viability. [3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
HUVEC NIryUmhIem:5dHigbY5pcWKrdH;yfUBie3OjeR?= MYLpcohq[mm2czD0bIUhXkWJRj3pcoR2[2WmIIDyc4xq\mW{YYTpc44hd2ZiSGXWSWN{ MXOxPFYzODN6Mh?=
HUVEC M3zMOmtqdmG|ZTDhd5NigQ>? NV2zRWU4cW6qaXLpeJMhXkWJRj3pcoR2[2WmIIDoc5NxcG:{eXzheIlwdiCxZjDWSWdHWi1{IHnuJGhWXkWFIHPlcIx{KHerdHigZY4hUUN3MDDv[kDjkLx6IH7N M37ifFE5PjJyM{iy
MM M1vKbmtqdmG|ZTDhd5NigQ>? NFH2c4hqdmirYnn0d{BXTUeILXnu[JVk\WRicHjvd5Bpd3K7bHH0bY9vKG:oIH\seFE> Mn\kNVcyPjR|M{K=
MM.1S M1ixWWdzd3e2aDDpcohq[mm2b4L5JIF{e2G7 M1zqc|ExKM7:Zz;tUC=> MnzXbY5pcWKrdIOgUW0hS2WubDDHdo94fGh? NX7qOmZTOTdzNkSzN|I>
MM.1R Mnn0S5Jwf3SqIHnubIljcXSxcomgZZN{[Xl? NUP3d|BFOTBizsznM41N Mk\JbY5pcWKrdIOgUW0hS2WubDDHdo94fGh? MYWxO|E3PDN|Mh?=
RPMI NGC4TndIem:5dHigbY5pcWKrdH;yfUBie3OjeR?= MYCxNEDPxGdxbVy= NGe1XVRqdmirYnn0d{BOVSCFZXzsJGdzd3e2aB?= M3XNdlE4OTZ2M{Oy
Dox40 M3j0Nmdzd3e2aDDpcohq[mm2b4L5JIF{e2G7 MXmxNEDPxGdxbVy= NFLMfZlqdmirYnn0d{BOVSCFZXzsJGdzd3e2aB?= NFy2V5kyPzF4NEOzNi=>
INA-6 MoPUS5Jwf3SqIHnubIljcXSxcomgZZN{[Xl? NXj1cYxiOTBizsznM41N MUjpcohq[mm2czDNUUBE\WyuIFfyc5d1cA>? MUCxO|E3PDN|Mh?=
OPM2 MnnES5Jwf3SqIHnubIljcXSxcomgZZN{[Xl? NFXXclIyOCEQvHevcWw> MnfrbY5pcWKrdIOgUW0hS2WubDDHdo94fGh? NInvNGsyPzF4NEOzNi=>
U266 M2H6Rmdzd3e2aDDpcohq[mm2b4L5JIF{e2G7 NWjseFgyOTBizsznM41N M{HaTYlvcGmkaYTzJG1OKEOnbHygS5Jwf3Sq MVSxO|E3PDN|Mh?=
MM.1S MknqZ5l1d3SxeHnjbZR6KGG|c3H5 NGHsSG0zOCEQvHevcWw> MU\pcohq[mm2czDNUUBE\WyuIGP1dpZqfmGu M3rn[lE4OTZ2M{Oy
MM.1R MVLjfZRwfG:6aXPpeJkh[XO|YYm= NGfp[3AzOCEQvHevcWw> NHvxdYhqdmirYnn0d{BOVSCFZXzsJHN2en[rdnHs NI\hO4QyPzF4NEOzNi=>
RPMI M1:yR4N6fG:2b4jpZ4l1gSCjc4PhfS=> MWWyNEDPxGdxbVy= NEO0THRqdmirYnn0d{BOVSCFZXzsJHN2en[rdnHs MYGxO|E3PDN|Mh?=
Dox40 M{e0OYN6fG:2b4jpZ4l1gSCjc4PhfS=> NV7YdnhuOjBizsznM41N Mk\HbY5pcWKrdIOgUW0hS2WubDDTeZJ3cX[jbB?= M3S2[VE4OTZ2M{Oy
INA-6 MUDjfZRwfG:6aXPpeJkh[XO|YYm= NFXVdowzOCEQvHevcWw> M1jQbolvcGmkaYTzJG1OKEOnbHygV5Vzfmm4YXy= NYna[ZJSOTdzNkSzN|I>
OPM2 MnH1Z5l1d3SxeHnjbZR6KGG|c3H5 Mm\3NlAh|rypL33M NYixT21WcW6qaXLpeJMhVU1iQ3XscEBUfXK4aY\hcC=> NGXBXlkyPzF4NEOzNi=>
U266 NIDLTnlkgXSxdH;4bYNqfHliYYPzZZk> MkPpNlAh|rypL33M M2TNNolvcGmkaYTzJG1OKEOnbHygV5Vzfmm4YXy= MlflNVcyPjR|M{K=
MM.1S NXm5boZqTnWwY4Tpc44h[XO|YYm= M3zr[pN2eHC{ZYPz[ZMhXkWJRj3JcoR2[2WmIFXu[I91cGWuaXHsJGNmdGxiUILvcIln\XKjdHnvckBidmRiTXnndoF1cW:wLh?= NUfZVHFoOTdzNkSzN|I>
MM.1R NXKzZ2ZrTnWwY4Tpc44h[XO|YYm= MV\zeZBxemW|c3XzJHZGT0ZvSX7keYNm\CCHbnTveIhmdGmjbDDD[YxtKFC{b3zp[oVz[XSrb36gZY5lKE2rZ4LheIlwdi5? M2G5WlE4OTZ2M{Oy
Dox40 MmXPSpVv[3Srb36gZZN{[Xl? NHW1WpF{fXCycnXzd4V{KF[HR1[tTY5lfWOnZDDFcoRwfGinbHnhcEBE\WyuIGDyc4xq\mW{YYTpc44h[W6mIF3p[5JifGmxbj6= NGLmSY0yPzF4NEOzNi=>
OPM2 Mn\1SpVv[3Srb36gZZN{[Xl? NEHL[5N{fXCycnXzd4V{KF[HR1[tTY5lfWOnZDDFcoRwfGinbHnhcEBE\WyuIGDyc4xq\mW{YYTpc44h[W6mIF3p[5JifGmxbj6= NELDTlUyPzF4NEOzNi=>
HBMEC NWfkZmY1T3Kxd4ToJIlvcGmkaYTvdpkh[XO|YYm= NHK1d4F,OTBizszN MnjSSG1UVw>? NEnER|NKSzVyPUGg{txO NXXmVZhNOjFyOEG2OVY>
HBMEC MYLGeY5kfGmxbjDhd5NigQ>? MVP+NUDPxE1? NYXFeZNYTE2VTx?= MnzWZYJzd2ejdHXzJJRp\SCyaH;zdIhwenmuYYTpc44hd2ZiVlXHSnIzKHerdHig[Il{enWydHnvckBw\iCmb4fud5Rz\WGvIGDMR:6{OQ>? NXPKSHdnOjFyOEG2OVY>
HBMEC NEK1SGhHfW6ldHnvckBie3OjeR?= MU\+NUDPxE1? M3HMWWROW09? MmjJ[Il{enWydIOgeIhmKFKjcz3SZYYuTVKNIIDheIh4[XlidHjyc5VocCCmZXPy[YF{\WRicHjvd5Bpd3K7bHH0[YQhVUWNMT:yJIFv\CCHUluxM|I> NHPvO3AzOTB6MU[1Oi=>
HBMEC M2roXmZ2dmO2aX;uJIF{e2G7 MWj+NlAh|ryP MWLEUXNQ NEHKd2llcXO{dYD0d{A2OCVib3[geJVj\SCob4LtZZRqd25iYYSgNUDPxE1? Mn60NlExQDF4NU[=
MDA-MB-231 MVnHdo94fGhiaX7obYJqfG:{eTDhd5NigQ>? NFXK[Fd,OTBizszN MULEUXNQ NETLbnFKSzVyPUWg{txO NGKxb3ozOTB6MU[1Oi=>
MDA-MB-231 MlPmSpVv[3Srb36gZZN{[Xl? MY[wMlUh|ryP M1jScWROW09? MX\pcohq[mm2czD0bIUhTVKNMT:yJJNq\26jbHnu[{Bx[XSqd3H5 NWjqZYw3OjFyOEG2OVY>
MDA-MB-231 NX62bWRKTnWwY4Tpc44h[XO|YYm= NWiwPFU6PSEQvF2= NFPDbG9FVVOR MVfpcoR2[2W|IHGgZ4VtdC2leXPs[UBienKnc4S= MViyNVA5OTZ3Nh?=
J82 M3O0[IN6fG:2b4jpZ4l1gSCjc4PhfS=> NID6fWx,OTBizszN NUjkXmE{TE2VTx?= M13SSmlEPTB;MkSuOVch|ryP NIfNWo4zOTV{OUmwNC=>
T24 Mn:1Z5l1d3SxeHnjbZR6KGG|c3H5 MlzVglExKM7:TR?= NGrjOJlFVVOR MoTiTWM2OD13Mj60OUDPxE1? MUeyNVUzQTlyMB?=
HT1376 NUG4XnYx[3m2b4TvfIlkcXS7IHHzd4F6 NIn1SHR,OTBizszN NHLWUYNFVVOR NGnrRW5KSzVyPUK4MlIyKM7:TR?= NHX6N5YzOTV{OUmwNC=>
RT4 NGr3bJpkgXSxdH;4bYNqfHliYYPzZZk> MVL+NVAh|ryP MU\EUXNQ MUnJR|UxRTVwMUSg{txO NVOxUJd3OjF3Mkm5NFA>
CRL1749 M1PSSYN6fG:2b4jpZ4l1gSCjc4PhfS=> M2\MNZ4yOCEQvF2= MXHEUXNQ M1rET2lEPTB;MkKuOlkh|ryP NX;XSZN1OjF3Mkm5NFA>
HTB9 NGXOUnRkgXSxdH;4bYNqfHliYYPzZZk> M1izeJ4yOCEQvF2= M1\YeWROW09? NELVXG5KSzVyPUGxMlg1KM7:TR?= MnnpNlE2Ojl7MEC=
Sup MlHrZ5l1d3SxeHnjbZR6KGG|c3H5 NVTOSW1KhjFyIN88US=> MV\EUXNQ NIWyeZVKSzVyPUWzMlMzKM7:TR?= NIrWT20zOTV{OUmwNC=>
HTB3 NEeyTpNkgXSxdH;4bYNqfHliYYPzZZk> MnjoglExKM7:TR?= NFzvemVFVVOR MVLJR|UxRTF2LkG2JO69VQ>? MWeyNVUzQTlyMB?=
CEC MmGzSpVv[3Srb36gZZN{[Xl? NUjSWoVQhjFyIN88[{9uVA>? M3;m[GROW09? Ml7G[I94di2{ZXf1cIF1\XNiVlXHSkBt\X[nbIO= NWnPOo5UOjF4MkC4NlI>
RPE Ml7ESpVv[3Srb36gZZN{[Xl? MmnCglExKM7:Zz;tUC=> MXHEUXNQ NUS0Vmlm\G:5bj3y[Yd2dGG2ZYOgWmVITiCuZY\lcJM> M2f5bFIyPjJyOEKy
CEC NYjhT4FFTnWwY4Tpc44h[XO|YYm= MYf+OUDPxGdxbVy= MXzEUXNQ MUPicI9kc3NiZX7kc5Rp\WyrYXygZ4VtdCCvaXfyZZRqd25? M1nUPFIyPjJyOEKy
5637 M1[4cGdzd3e2aDDpcohq[mm2b4L5JIF{e2G7 M1[5b2ROW09? M1rnZ2lEPTB;MUWuNQKBkc7:TR?= M2LseVI{QDh5NkC1
J82 MnnoS5Jwf3SqIHnubIljcXSxcomgZZN{[Xl? MVrEUXNQ NVLYZohGUUN3ME2xPE416oDLzszN NVjaS3FIOjN6OEe2NFU>
5637 NIC5c4VCfXSxcHjh[5kh[XO|YYm= MlXjNlAh|ryP NF3jfHNFVVOR NWDGVGtCfHKrZ3fldpMhfGinIHH1eI9xcGGpaXOgdJJw[2W|cx?= NWfTNlBnOjN6OEe2NFU>
J82 M1mx[GF2fG:yaHHnfUBie3OjeR?= NH\wfHIzOCEQvF2= Mn3lSG1UVw>? M3T3V5RzcWepZYLzJJRp\SCjdYTvdIhi\2mlIIDyc4Nme3N? M2DhZlI{QDh5NkC1
5637 NI\1eoRHfW6ldHnvckBie3OjeR?= NXrXUnp3OjBizszN MYDEUXNQ MmPNbY5lfWOnczDsfZNwe2:vYXyt[IVx\W6mZX70JI5m[3Kxc3nz MXuyN|g5PzZyNR?=
J82 MojSSpVv[3Srb36gZZN{[Xl? MnTXNlAh|ryP MV\EUXNQ MVfpcoR2[2W|IHz5d49{d22jbD3k[ZBmdmSnboSgcoVkem:|aYO= NUDMdZNzOjN6OEe2NFU>
5637 Mk\LSpVv[3Srb36gZZN{[Xl? MYKyNEDPxE1? Mlj5SG1UVw>? MVnpcoR2[2W|IHz5d49{d22nIHHseIVz[XSrb36gZY5lKGmwaHnibZR{KEOEIHHjeIl3cXS7 NXy5S|AxOjN6OEe2NFU>
J82 NXvuWG1JTnWwY4Tpc44h[XO|YYm= MnjUNlAh|ryP M2DxWWROW09? M2PuTolv\HWlZYOgcJl{d3OxbXWgZYx1\XKjdHnvckBidmRiaX7obYJqfHNiQ1KgZYN1cX[rdIm= NFPKWnkzOzh6N{[wOS=>
KATO-II M1m4VGdzd3e2aDDpcohq[mm2b4L5JIF{e2G7 NGm0[oo2KM7:TR?= NHjsOHBFVVOR NH;XRpZjdG:la4OgdJJwdGmoZYLheIlwdg>? MVyyOVI1QTV3Nx?=
OCUM-2M MYTHdo94fGhiaX7obYJqfG:{eTDhd5NigQ>? MXi1JO69VQ>? NYTzdlF2TE2VTx?= MmLNZoxw[2u|IIDyc4xq\mW{YYTpc44> Mn3nNlUzPDl3NUe=
SNU-16 NGn4cWdIem:5dHigbY5pcWKrdH;yfUBie3OjeR?= NH7kUG42KM7:TR?= NXfFVm5MTE2VTx?= NIHFfY1jdG:la4OgdJJwdGmoZYLheIlwdg>? M37QblI2OjR7NUW3
HSC-39 NXLuUJJlT3Kxd4ToJIlvcGmkaYTvdpkh[XO|YYm= NXjF[JJwPSEQvF2= MYXEUXNQ NXH5[lN1[myxY3vzJJBzd2yrZnXyZZRqd25? MlryNlUzPDl3NUe=
KATO-II MU\jfZRwfG:6aXPpeJkh[XO|YYm= M3vYeZ4yOCEQvF2= NVTjPHpbTE2VTx?= MXnJR|UxRTBwMTD0c{AzNjBizsztc4wwVA>? MkHJNlUzPDl3NUe=
OCUM-2M M4C5Z4N6fG:2b4jpZ4l1gSCjc4PhfS=> M2\VdJ4yOCEQvF2= NYftfItzTE2VTx?= MVrJR|UxRTBwMTD0c{AzNjBizsztc4wwVA>? NGnDWVYzPTJ2OUW1Oy=>
SNU-16 M1K1OYN6fG:2b4jpZ4l1gSCjc4PhfS=> M3G2Up4yOCEQvF2= MXjEUXNQ M3zlRWlEPTB;MD6xJJRwKDJwMDFOwI1wdC:O M3K5WVI2OjR7NUW3
HSC-39 MkXlZ5l1d3SxeHnjbZR6KGG|c3H5 M3uxRZ4yOCEQvF2= M{[5fmROW09? NFnmO2dKSzVyPUCuNUB1dyB{LkCg{txud2xxTB?= MVmyOVI1QTV3Nx?=
NIH 3T3 MmrzS5Jwf3SqIHnubIljcXSxcomgZZN{[Xl? MoPaglExKM7:TR?= M1rkZ2ROW09? NF24cHNqdmirYnn0d{Bk\WyuIHfyc5d1cCCjbnSgZ49td267IH\vdo1ifGmxbh?= MoDENlUzPDl3NUe=
KATO-III M2T0ZmZ2dmO2aX;uJIF{e2G7 NYHMXmdPOSEQvF2= MXLEUXNQ NFrLW2tqdmS3Y3XzJINmdGxvY4njcIUh[XK{ZYP0 NFvSSnMzPTJ2OUW1Oy=>
OCUM-2M NFT6cFVHfW6ldHnvckBie3OjeR?= MmGxNUDPxE1? NYrmXlZQTE2VTx?= NETo[YlqdmS3Y3XzJINmdGxvY4njcIUh[XK{ZYP0 M4eyUlI2OjR7NUW3
KATO-III MWnBdI9xfG:|aYOgZZN{[Xl? M1zJSFEh|ryP MYXEUXNQ MnHObY5lfWOnczDhdI9xfG:|aYO= NYLPOGVEOjV{NEm1OVc>
OCUM-2M M3;jR2Fxd3C2b4Ppd{Bie3OjeR?= MmDQNUDPxE1? NWfI[nhrTE2VTx?= M1GyUolv\HWlZYOgZZBweHSxc3nz MUiyOVI1QTV3Nx?=
KATO-III M2rscmZ2dmO2aX;uJIF{e2G7 MV6xJO69VQ>? M4T2NWROW09? M1TpRolvcGmkaYTzJGZITlJ{IIDoc5NxcG:{eXzheIlwdiCjbnSg[I94dnO2cnXhcUB{cWewYXzpcochdW:uZXP1cIV{ NFW4cJczPTJ2OUW1Oy=>

... Click to View More Cell Line Experimental Data

In vivo The mice treated with 30 mg/kg or 100 mg/kg Pazopanib reveals a significant decrease in tumor burden compared with the mice treated with vehicle or 10 mg/kg Pazopanib. Treatment with Pazopanib is well-tolerated and there is no significant difference in the body weight among the mice in each group. [2]

Protocol

Kinase Assay:

[1]

+ Expand

Kinase enzyme assays:

VEGFR enzyme assays for VEGGR1, VEGFR2, and VEGFR3 are run in homogeneous time-resolved fluorescence (HTRF) format in 384-well microtiter plates using a purified, baculovirus-expressed glutathione-S-transferase (GST) fusion protein encoding the catalytic c-terminus of human VEGFR receptor kinases 1, 2, or 3. Reactions are initiated by the addition of 10 μL of activated VEGFR2 kinase solution [final concentration, 1 nM enzyme in 0.1 M HEPES, pH 7.5, containing 0.1 mg/mL bovine serum albumin (BSA), 300 μM dithiothreitol (DTT)] to 10 μL substrate solution [final concentration, 360 nM peptide, (biotin-aminohexyl-EEEEYFELVAKKKK-NH2), 75 μM ATP, 10 μM MgCl2], and 1 μL of titrated Pazopanib in DMSO. Plates are incubated at room temperature for 60 min, and then the reaction is quenched by the addition of 20 μL of 100 mM ethylene diamine tetraacetic acid (EDTA). After quenching, 20 μL HTRF reagents (final concentration, 15 nM Streptavidin-linked allophycocyanin, 1 nM Europium-labeled antiphosphotyrosine antibody diluted in 0.1 mg/mL BSA, 0.1 M HEPES, pH 7.5) is added and the plates incubated for a minimum of 10 min. The fluorescence at 665 nM is measured with a Wallac Victor plate reader using a time delay of 50 μs.
Cell Research:

[1]

+ Expand
  • Cell lines: HUVEC cells
  • Concentrations: 0-10 μM
  • Incubation Time: 1 hour
  • Method:

    Phosphorylation of VEGFR2 is assessed in HUVEC stimulated with VEGF. HUVEC are plated in type-I collagen-coated 10 cm plates in Clonetics EGM-MV medium at 1.0-1.5 × 106 cells/plate. After 24 hours, the confluent cells are serum starved overnight by replacing the growth medium with Clonetics EBM medium containing 0.1% BSA, 500 μg/mL hydrocortisone. Cells are treated with Pazopanib at various concentrations for 1 hour, followed by addition of 10 ng/mL VEGF or vehicle for 10 min. Cells are solubilized in lysis buffer. VEGFR2 is immunoprecipitated using antiflk-1 antibody and analyzed by sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE) followed by Western blotting and detection with antiflk-1 or with antiphosphotyrosine (anti-P-tyr-biotin) antibody. The VEGFR2 phosphorylation level is quantified by densitometry and normalized to the total VEGFR2 level.


    (Only for Reference)
Animal Research:

[2]

+ Expand
  • Animal Models: Immunodeficient mice bearing SYO-1 cells
  • Formulation: --
  • Dosages: 0 mg/kg, 10 mg/kg, 30 mg/kg, or 100 mg/kg
  • Administration: Oral administration
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 17 mg/mL (35.86 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents to the product individually and in order:
30% PEG400+0.5% Tween80+5% propylene glycol
For best results, use promptly after mixing.
30 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 473.98
Formula

C21H23N7O2S.HCl

CAS No. 635702-64-6
Storage powder
Synonyms N/A

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    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02300545 Recruiting Sarcoma, Soft Tissue|Soft Tissue Sarcoma Washington University School of Medicine April 8, 2015 Phase 2
NCT00674024 Completed Neoplasms|Lymphoma National Cancer Institute (NCI)|National Institutes of Health Clinical Center (CC) October 7, 2008 Phase 1
NCT01716416 Recruiting Squamous Cell Carcinoma of the Head and Neck Washington University School of Medicine May 31, 2013 Phase 1
NCT01462630 Recruiting Adult Angiosarcoma|Recurrent Adult Soft Tissue Sarcoma|Stage III Adult Soft Tissue Sarcoma|Stage IV Adult Soft Tissue Sarcoma Fox Chase Cancer Center|National Cancer Institute (NCI) November 3, 2011 Phase 2
NCT01468922 Completed Sarcoma|Stomach Neoplasms|Neoplasms National Cancer Institute (NCI)|National Institutes of Health Clinical Center (CC) October 24, 2011 Phase 1
NCT02342600 Not yet recruiting Gastrointestinal Stromal Tumors Sarcoma Alliance for Research through Collaboration|Novartis January 2017 Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

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VEGFR Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID