Catalog No.S1356 Synonyms: UCB-L059, SIB-S1

Levetiracetam Chemical Structure

Molecular Weight(MW): 170.21

Levetiracetam is an anticonvulsant medication used to treat epilepsy.

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In DMSO USD 130 In stock
USD 97 In stock
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  • Levetiracetam reduces DNA, synaptic, and neurite damage caused by Dox. (A) An example of cortical cultures pre-treated with 5 μ M Lev and then Dox (0.01 μ M, overnight), fixed and stained with antibodies against MAP2c. Scale bar is 20 μ m. (B) Cortical neurons at 28–32 DIV were pre-treated with 5 μ M Lev, and then a vehicle or with Dox (0.01 μ M for 3 days, or 0.1 μ M, overnight) was added. Neurons were fixed, and stained for MAP2c, synapsin, and with the Hoechst dye, and imaged. Note that red MAP2c staining also includes Dox's red fluorescence. (C) Synaptically developed primary cortical cultures at 28−32 DIV were pretreated with 5 mM Lev, and then a vehicle or with Dox (0.01 μM for 3 days, or 0.1 μM, overnight) was added. Neurons were then fixed, and stained with antibodies against γH2A.X and MAP2c, and with the Hoechst dye. Blue staining was used by the algorithm to identify and analyze γH2A.X.

    Sci Rep, 2016, 6:25705.. Levetiracetam purchased from Selleck.

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Biological Activity

Description Levetiracetam is an anticonvulsant medication used to treat epilepsy.
Calcium channel [1]
In vitro

Levetiracetam and related compounds bind to SV2A expressed in fibroblasts, indicating that SV2A is sufficient for Levetiracetam binding. [1] Levetiracetam irreversibly inhibits the high-voltage-activated (HVA) calcium current by approximately 18% on the average in freshly isolated CA1 hippocampal neurons of rats. Levetiracetam selectively inhibits N-type Ca2+ channels of CA1 pyramidal hippocampal neurons. [2] Levetiracetam reverses the inhibitory effect of DMCM on GABA-elicited currents in hippocampal neurons. [3]

In vivo Levetiracetam (17 mg/kg) produces a potent suppression of sound-induced clonic convulsions in mice, and this protective effect is significantly abolished by co-administration of the beta-carboline FG 7142. [3] Levetiracetam exerts potent anticonvulsant activity against both focal and secondarily generalized seizures in fully amygdala-kindled rats, i.e. , a model of temporal lobe epilepsy. Levetiracetam (13 mg/kg, 27 mg/kg or 54 mg/kg, i.p.) dose-dependently suppresses the increase in seizure severity and duration induced by repeated amygdala stimulation. Levetiracetam has a relatively short half-life (about 2-3 hours) in rats. [4] Levetiracetam (5.4 mg/kg to 96 mg/kg i.p.) dose-dependently inhibits both wild running and tonic-clonic convulsions in the audiogenic-seizure prone rat. Levetiracetam markedly suppresses spontaneous spike-and-wave discharge (SWD) but leaves the underlying EEG trace normal in the GAERS model of petit mal epilepsy. [5]


Solubility (25°C)

In vitro DMSO 34 mg/mL (199.75 mM)
Water 34 mg/mL (199.75 mM)
Ethanol 34 mg/mL (199.75 mM)
In vivo Add solvents individually and in order:
30 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 170.21


CAS No. 102767-28-2
Storage powder
Synonyms UCB-L059, SIB-S1

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03034356 Not yet recruiting Schizophrenia VA Office of Research and Development October 2017 --
NCT02815410 Not yet recruiting Glioblastoma Multiforme Seoul National University Hospital July 2016 Phase 2
NCT02603991 Recruiting Epileptic Encephalopathy Beijing Pins Medical Co., Ltd June 2016 --
NCT02707965 Not yet recruiting Epilepsy Food and Drug Administration (FDA)|University of Maryland March 2016 --
NCT02602860 Completed Healthy Volunteers UCB Biopharma S.P.R.L.|PRA Health Sciences|Yale University|UCB Pharma November 2015 Phase 1
NCT01960075 Recruiting Benzodiazepine Refractory Status Epilepticus University of Virginia|University of Michigan|Medical University of South Carolina|Childrens Research Institute|University of Minnesota - Clinical and Translational Science Institute|National Institute of Neurological Disorders and Stroke (NINDS) October 2015 Phase 3

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