Nilvadipine

Catalog No.S2721

Nilvadipine is a potent calcium channel blocker with an IC50 of 0.03 nM.

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In DMSO USD 90 In stock
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Nilvadipine Chemical Structure

Nilvadipine Chemical Structure
Molecular Weight: 385.37

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Product Description

Biological Activity

Nilvadipine (ARC029) is a potent calcium channel blocker with an IC50 of 0.03 nM. Nilvadipine (ARC029) is used for the treatment of hypertension and chronic major cerebral artery occlusion. [1] Nilvadipine (ARC029) were administrated  intramuscularly in daily doses of 0.01-10 mg/kg for three weeks, starting on the day of cuff-placement. Nilvadipine (ARC029) prvented the cuff-induced intimal thickening in a dose-dependent manner, and was more potent than the other calcium antagonists including nifedipine, diltiazem and verapamil. In an in vitro experiment on inhibition of migration of rat aortic smooth muscle cells, using zymosan-activated air pouch exudate as a chemoattractant in modified Boyden chambers, Nilvadipine (ARC029) was also the most potent among the calcium antagonists tested. The IC50 values were 0.17 nM for nifedipine, 6 nM for verapamil and 0.24 mM for diltiazem. Effects of these drugs on proliferation of rat aortic smooth muscle cells and rabbit platelet aggregation were also examined in vitro. At concentrations less than 10 mM, none of the drugs inhibited proliferation of the smooth muscle cells, and only verapamil inhibited collagen-induced platelet aggregation (IC50 = 0.9 mM).

Chemical Information

Download Nilvadipine SDF
Molecular Weight (MW) 385.37
Formula

C19H19N3O6

CAS No. 75530-68-6
Storage 3 years -20℃Powder
6 months-80℃in DMSO
Synonyms ARC029, FR34235
Solubility (25°C) * In vitro DMSO 77 mg/mL (199 mM)
Water <1 mg/mL (<1 mM)
Ethanol 33 mg/mL (85 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Chemical Name 5-isopropyl 3-methyl 2-cyano-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

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