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Manidipine dihydrochloride (CV-4093) Chemical Structure
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Biological Activity
Manidipine dihydrochloride (CV-4093) is a hydrochloride salt of manidipine that is a lipophilic, third-generation, highly vasoselective dihydropyridine calcium antagonist with an IC50 of 2.6 nM. Manidipine dihydrochloride (CV-4093) causes systemic vasodilation by inhibiting the voltage-dependent calcium inward currents in smooth muscle cells. Manidipine dihydrochloride (CV-4093) is used clinically as an antihypertensive. [1][2][3] Manidipine dihydrochloride (CV-4093) suppressed the DNA synthesis of vascular smooth muscle cells (VSMC) dose dependently at concentrations of more than 10 nM. Mandipine hydrochloride (1 µM) suppressed proliferation of VSMC to 50% of the control value. Manidipine hydrochloride stimulated the synthesis of GAG at concentrations above 0.01 nM. Manidipine hydrochloride (10 nM) stimulated synthesis of glycosaminoglycans(GAG) to 450% of control. [4]
References on Manidipine dihydrochloride (CV-4093)
- [1] http://en.wikipedia.org/wiki/Manidipine ;
- [2] Drugs. 2001;61(12):1777-99.
- [3] J Cardiovasc Pharmacol. 1992 Dec;20(6):895-9.
- [4] Blood Press Suppl. 1992;3:27-9.
Chemical Information
| Molecular Weight (WM): | 683.62 |
|---|---|
| Formula: | C35H38N4O6.2HCl |
| CAS No.: | 89226-75-5 |
| Synonyms: |
N/A
|
| Dissolve in (25°C): | DMSO ≥11mg/mL |
| Water <1mg/mL | |
| Ethanol <1mg/mL | |
| Storage: | 2 years-20°CPowder |
| 1 week-4°Cin DMSO | |
| 1 month-80°in DMSO |
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