Cinnarizine
Catalog No.S4727 Synonyms: Stugeron|Dimitronal|Stutgin|Cinarizine
Molecular Weight(MW): 368.51
Cinnarizine is a medication derivative of piperazine, and characterized as an antihistamine and a calcium channel blocker.
Purity & Quality Control
Choose Selective Calcium Channel Inhibitors
Biological Activity
| Description | Cinnarizine is a medication derivative of piperazine, and characterized as an antihistamine and a calcium channel blocker. | ||
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| In vitro |
Cinnarizine inhibits melanogenesis in B16 cells by a dose-dependent manner at the non-cytotoxic concentrations and is a histamine receptor antagonists[3]. |
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| In vivo | Cinnarizine has anticonvulsive properties in rats and mice. It could provide a direct neuroprotective effect against the damaging influx of calcium and also prevent neuronal damage as a result of MES- and PTZ-induced seizures[2]. Cinnarizine induces behavioural changes such as alopecia, bucolingual dyskinesia and reduction of motor activity in female parkin knock out (PK-KO) mice but not in wild-type (WT) controls.PK-KO mice have high striatal dopamine levels and increased dopamine metabolism in spite of low reduced tyrosine hydroxylase protein. Cinnarizine, which blocks dopamine receptors and increases dopamine release, further increased dopamine metabolism[3]. Its half-life is 4 hours. |
Protocol
| Cell Research:[4] |
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| Animal Research:[2] |
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Solubility (25°C)
| In vitro | DMSO | 73 mg/mL (198.09 mM) |
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| Water | Insoluble | |
| Ethanol | Insoluble |
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Chemical Information
| Molecular Weight | 368.51 |
|---|---|
| Formula | C26H28N2 |
| CAS No. | 298-57-7 |
| Storage | powder |
| Synonyms | Stugeron|Dimitronal|Stutgin|Cinarizine |
Bio Calculators
Molarity Calculator
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