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Wnt/beta-catenin Inhibitors (10)


Cat.No. Product Name Information Product Use Citation Customer Product Validation
S1180 XAV-939 XAV-939 selectively inhibits Wnt/β-catenin-mediated transcription through tankyrase1/2 inhibition with IC50 of 11 nM/4 nM in cell-free assays, regulates axin levels and does not affect CRE, NF-κB or TGF-β.
  • Nat Cell Biol, 2014, 16(2):179-90
  • Nat Commun, 2014, 5:5455
  • Cancer Res, 2014, 74(20):5866-77
S2662 ICG-001 ICG-001 antagonizes Wnt/β-catenin/TCF-mediated transcription and specifically binds to element-binding protein (CBP) with IC50 of 3 μM, but is not the related transcriptional coactivator p300.
  • Eur Heart J, 2016, 10.1093/eurheartj/ehw116
  • Genes Dev, 2014, 28(8):858-74
  • Mol Cancer Ther, 2014, 13(10):2303-14
S7086 IWR-1-endo IWR-1-endo is a Wnt pathway inhibitor with IC50 of 180 nM in L-cells expressing Wnt3A, induces Axin2 protein levels and promotes β-catenin phosphorylation by stabilizing Axin-scaffolded destruction complexes.
  • Am J Cancer Res, 2014, 6(6):724-735
S7037 Wnt-C59 (C59) Wnt-C59 (C59) is a PORCN inhibitor for Wnt3A-mediated activation of a multimerized TCF-binding site driving luciferase with IC50 of 74 pM in HEK293 cells.
  • Stem Cell Res, 2016, 16(3):740-50
  • Dev Neurobiol, 2015, 10.1002/dneu.22370
S7143 LGK-974 LGK-974 is a potent and specific PORCN inhibitor, and inhibits Wnt signaling with IC50 of 0.4 nM in TM3 cells. Phase 1.
  • J Clin Endocrinol Metab, 2015, 10.1210/jc.2015-1734
  • Breast Cancer Res, 2014, 16(4):408
  • Exp Eye Res, 2015, 132C:174-178
S7096 KY02111 KY02111 promotes differentiation of hPSCs to cardiomyocytes by inhibiting Wnt signaling, may act downstream of APC and GSK3β.
  • Exp Eye Res, 2015, 132C:174-178
S7085 IWP-2 IWP-2 is an inhibitor of Wnt processing and secretion with IC50 of 27 nM in a cell-free assay, selective blockage of Porcn-mediated Wnt palmitoylation, does not affect Wnt/β-catenin in general and displays no effect against Wnt-stimulated cellular responses.
  • nature, 2016, 10.1038/nature17408
  • Proc Natl Acad Sci USA, 2013, 110(52):E5039-48
  • Methods, 2015, S1046-2023(15)30081-5
S7484 FH535 FH535 is a Wnt/β-catenin signaling inhibitor and also a dual PPARγ and PPARδ antagonist.
S7490 WIKI4 WIKI4 is a novel Tankyrase inhibitor with IC50 of 15 nM for TNKS2, and leads to inhibition of Wnt/beta-catenin signaling.
S7301 IWP-L6 IWP-L6 is a highly potent Porcn inhibitor with EC50 of 0.5 nM.

Hover Mouse over '+' to display IC50

Cat.No. Product Name Solubility (25°C)
Water DMSO Ethanol
S1180 XAV-939 <1 mg/mL 12 mg/mL <1 mg/mL
S2662 ICG-001 <1 mg/mL 100 mg/mL 10 mg/mL
S7086 IWR-1-endo <1 mg/mL 30 mg/mL <1 mg/mL
S7037 Wnt-C59 (C59) <1 mg/mL 76 mg/mL <1 mg/mL
S7143 LGK-974 <1 mg/mL 79 mg/mL <1 mg/mL
S7096 KY02111 <1 mg/mL 75 mg/mL <1 mg/mL
S7085 IWP-2 <1 mg/mL 4 mg/mL <1 mg/mL
S7484 FH535 <1 mg/mL 72 mg/mL <1 mg/mL
S7490 WIKI4 <1 mg/mL 7 mg/mL <1 mg/mL
S7301 IWP-L6 <1 mg/mL 25 mg/mL <1 mg/mL
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