Catalog No.S7086

IWR-1-endo Chemical Structure

Molecular Weight(MW): 409.44

IWR-1-endo is a Wnt pathway inhibitor with IC50 of 180 nM in L-cells expressing Wnt3A, induces Axin2 protein levels and promotes β-catenin phosphorylation by stabilizing Axin-scaffolded destruction complexes.

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1 Customer Review

  • (F) UNC119 influences the activity of Wnt/β-catenin signaling. β-catenin inhibitor IWR-1-endo significantly inhibits SKHep1 proliferation.

    Am J Cancer Res, 2015, 5(10):3123-3134.. IWR-1-endo purchased from Selleck.

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Biological Activity

Description IWR-1-endo is a Wnt pathway inhibitor with IC50 of 180 nM in L-cells expressing Wnt3A, induces Axin2 protein levels and promotes β-catenin phosphorylation by stabilizing Axin-scaffolded destruction complexes.
Wnt [1]
(L-cells expressing Wnt3A)
180 nM
In vitro

Although both IWR-1 and XAV939 act as reversible Wnt pathway inhibitors and exhibit similar pharmacological effects both in vitro and in vivo, IWR-1 exerts its effect via interaction with Axin, while XAV939 binds TNKS directly. [1]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
human HEK293T cells  NFm2dW5HfW6ldHnvckBie3OjeR?= M4PhfWlvcGmkaYTpc44hd2ZiYnX0ZU1k[XOnaX6t[IVx\W6mZX70JINidm:waXPhcEBYdnR|IIDheIh4[XliaX6gbJVu[W5iSFXLNlk{XCClZXzsd{BjgSCudXPp[oVz[XOnIILldI9zfGW{IHflcoUh[XO|YYmsJGlEPTB;MD6wNlYh|ryP MYSyNlE6OTV3Nx?=
mouse L-Wnt-STF cells MmfsSpVv[3Srb36gZZN{[Xl? Mn3MTY5pcWKrdHnvckBw\iCWTlvTMVIhcW5ibX;1d4UhVC2ZboStV3RHKGOnbHzzJIF{e2W|c3XkJIF{KGSrc4L1dJRqd25ib3[gW451KHOrZ37hcIlv\yCjZoTldkAzPCCqcoOgZpkhdHWlaX\ldoF{\SC{ZYDvdpRmeiCpZX7lJIF{e2G7LDDJR|UxRTBwMEW2JO69VQ>? MVuyOFUzPzd7Mh?=
mouse L-Wnt-STF cells M4jCSWZ2dmO2aX;uJIF{e2G7 MnrXTY5pcWKrdHnvckBw\iCWTlvTMVEhcW5ibX;1d4UhVC2ZboStV3RHKGOnbHzzJIF{e2W|c3XkJIF{KGSrc4L1dJRqd25ib3[gW451KHOrZ37hcIlv\yCjZoTldkAzPCCqcoOgZpkhdHWlaX\ldoF{\SC{ZYDvdpRmeiCpZX7lJIF{e2G7LDDJR|UxRTBwMUOxJO69VQ>? M33SRlI1PTJ5N{my
Escherichia coli BL21 (DE3) cells MoHOSpVv[3Srb36gZZN{[Xl? MXK5NEBucW6| Ml75RYN1cX[rdImgc4YhVi22ZYLtbY52eyCqZYjhTIl{NXSjZ3fl[EBpfW2jbjDUUnNMOiCneIDy[ZN{\WRiaX6gSZNkcGW{aXPobYEh[2:uaTDCUFIyKCiGRUOpJINmdGy|IIXzbY5oKGKrb4Tpcplt[XSnZDDORWQsKGG|IIP1ZpN1emG2ZTDh[pRmeiB7MDDtbY5{KGK7IGfld5Rmem5iYnzveEBidmGueYPpd{whTUN3ME2wMlIh|ryP MlO1NlIzOzN|MkC=
human SW480 cells MX;GeY5kfGmxbjDhd5NigQ>? M3vVPFQxKHSxIES4JIg> M4LCV2lvcGmkaYTpc44hd2ZidHHub5lz[XOnIHnuJIh2dWGwIGPXOFgxKGOnbHzzJIF{e2W|c3XkJIF{KGSnZ4Lh[IF1cW:wIH;mJIJmfGFiY3H0[Y5qdiCjZoTldkA1OCC2bzC0PEBpenNuIFnDOVA:OC5{NTFOwG0> M4\NW|I{PzBzNUG3
human SW480 cells MX7GeY5kfGmxbjDhd5NigQ>? M3jwOlI1KGh? NFK0R5pKdmirYnn0bY9vKG:oIIThcot6emG|ZTDpckBpfW2jbjDTW|Q5OCClZXzsd{Bie3Onc4Pl[EBieyCjY3P1cZVt[XSrb36gc4Yh[XirbkKgZYZ1\XJiMkSgbJJ{KGK7IFjv[YNpe3RiZInlMYJie2WmIH3leIhw\A>? NGDXblczOzdyMUWxOy=>
human HT29 cells NXLGT5lmTnWwY4Tpc44h[XO|YYm= Mn\TNlQhcA>? NHK4RWlKdmirYnn0bY9vKG:oIGfueEB{cWewYXzpcochcW5iaIXtZY4hUFR{OTDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKGKndHGtZ4F1\W6rbj3t[YRq[XSnZDDUZ4YwVGWoIITyZY5{[3KrcITpc45idCCjY4Tpeol1gSCjZoTldkAzPCCqcoOgZpkh\HWjbDDseYNq\mW{YYPlJJJmeG:{dHXyJIdmdmViYYPzZZkhemWuYYTpeoUhfG9iY3;ueJJwdCxiSVO1NF0zPC52IN88US=> MlGxNlQ6PTB2OEm=
human HT29 cells NGn1dYZHfW6ldHnvckBie3OjeR?= NHLqfIQzPSEQvF2= NYTtc2lmOjRiaB?= MYPJcohq[mm2aX;uJI9nKFewdDDzbYdv[WyrbnegbY4hcHWvYX6gTHQzQSClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJIJmfGFvY3H0[Y5qdi2vZXTpZZRm\CCWY3[vUIVnKHS{YX7zZ5JqeHSrb37hcEBi[3Srdnn0fUBifCB{NTD1UUBi\nSncjCyOEBpenNiYomg[JVidCCudXPp[oVz[XOnIILldI9zfGW{IHflcoUh[XO|YYmgdoVt[XSrdnWgeI8h[2:wdILvcEBqdiCycnXz[Y5k\SCxZjDHV2suO2KndHGgbY5pcWKrdH;yJGxqS2x? MoLMNlQ6PTB2OEm=
human DLD1 cells MWfGeY5kfGmxbjDhd5NigQ>? M3zEO|IhcA>? NYHxSWlpUW6mdXP0bY9vKG:oIFH4bY4zKHO2YXLpcIl7[XSrb36gbY4hcHWvYX6gSGxFOSClZXzsd{Bie3Onc4Pl[EBieyCmZXPy[YF{\WRidILhcpNkemmydHnvckBw\iCDeHnuNkBi\nSncjCyJIhzeyCkeTDSWE1RS1JibXX0bI9lNg>? Ml\0NVkyOjVzNU[=
HEK293 cells MUnGeY5kfGmxbjDhd5NigQ>? MmPUSIl{eGyjY3Xt[Y51KG:oIFnXVk1RSiCocn;tJGF5cW5{IHnuJGhGUzJ7MzDj[YxteyCkeTDX[ZN1\XKwIHLsc5QhdWW2aH;k NGPHUo0yQTF{NUG1Oi=>

... Click to View More Cell Line Experimental Data


Solubility (25°C)

In vitro DMSO 21 mg/mL (51.28 mM)
Water Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 409.44


CAS No. 1127442-82-3
Storage powder
Synonyms N/A

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID