IWR-1-endo

Catalog No.S7086

IWR-1-endo Chemical Structure

Molecular Weight(MW): 409.44

IWR-1-endo is a Wnt pathway inhibitor with IC50 of 180 nM in L-cells expressing Wnt3A, induces Axin2 protein levels and promotes β-catenin phosphorylation by stabilizing Axin-scaffolded destruction complexes.

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USD 250 In stock

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1 Customer Review

  • (F) UNC119 influences the activity of Wnt/β-catenin signaling. β-catenin inhibitor IWR-1-endo significantly inhibits SKHep1 proliferation.

    Am J Cancer Res, 2015, 5(10):3123-3134.. IWR-1-endo purchased from Selleck.

Purity & Quality Control

Choose Selective Wnt/beta-catenin Inhibitors

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Notes:

2. For more details, such as half maximal inhibitory concentrations (IC50s) and working concentrations of each inhibitor, please click on the link of the inhibitor of interest.
3. "+" indicates inhibitory effect. Increased inhibition is marked by a higher "+" designation.
4. Orange "√" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

Biological Activity

Description IWR-1-endo is a Wnt pathway inhibitor with IC50 of 180 nM in L-cells expressing Wnt3A, induces Axin2 protein levels and promotes β-catenin phosphorylation by stabilizing Axin-scaffolded destruction complexes.
Targets
Wnt [1]
(L-cells expressing Wnt3A)
180 nM
In vitro

Although both IWR-1 and XAV939 act as reversible Wnt pathway inhibitors and exhibit similar pharmacological effects both in vitro and in vivo, IWR-1 exerts its effect via interaction with Axin, while XAV939 binds TNKS directly. [1]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
human HEK293T cells  M1jwSmZ2dmO2aX;uJIF{e2G7 Mn7UTY5pcWKrdHnvckBw\iCkZYThMYNie2Wrbj3k[ZBmdmSnboSgZ4Fvd26rY3HsJHdvfDNicHH0bJdigSCrbjDoeY1idiCKRVuyPVNVKGOnbHzzJIJ6KGy3Y3nm[ZJie2VicnXwc5J1\XJiZ3Xu[UBie3OjeTygTWM2OD1yLkCyOkDPxE1? MlLHNlIyQTF3NUe=
mouse L-Wnt-STF cells MWHGeY5kfGmxbjDhd5NigQ>? M4XvdGlvcGmkaYTpc44hd2ZiVF7LV{0zKGmwIH3veZNmKExvV370MXNVTiClZXzsd{Bie3Onc4Pl[EBieyCmaYPyeZB1cW:wIH;mJHdvfCC|aXfuZYxqdmdiYX\0[ZIhOjRiaILzJIJ6KGy3Y3nm[ZJie2VicnXwc5J1\XJiZ3Xu[UBie3OjeTygTWM2OD1yLkC1OkDPxE1? M1j2[lI1PTJ5N{my
mouse L-Wnt-STF cells NFjvPGtHfW6ldHnvckBie3OjeR?= MnHyTY5pcWKrdHnvckBw\iCWTlvTMVEhcW5ibX;1d4UhVC2ZboStV3RHKGOnbHzzJIF{e2W|c3XkJIF{KGSrc4L1dJRqd25ib3[gW451KHOrZ37hcIlv\yCjZoTldkAzPCCqcoOgZpkhdHWlaX\ldoF{\SC{ZYDvdpRmeiCpZX7lJIF{e2G7LDDJR|UxRTBwMUOxJO69VQ>? NWewWWtGOjR3Mke3PVI>
Escherichia coli BL21 (DE3) cells NVnETpJQTnWwY4Tpc44h[XO|YYm= MmG5PVAhdWmwcx?= NW\tbIt5SWO2aY\peJkhd2ZiTj30[ZJucW63czDo[ZhiUGm|LYTh[4dm\CCqdX3hckBVVlONMjDlfJBz\XO|ZXSgbY4hTXOlaHXybYNpcWFiY3;sbUBDVDJzIDjESVMqKGOnbHzzJJV{cW6pIHLpc5RqdnmuYYTl[EBPSURtIHHzJJN2[nO2cnH0[UBi\nSncjC5NEBucW6|IHL5JHdme3Sncn6gZoxwfCCjbnHsfZNqeyxiRVO1NF0xNjJizszN M1viVVIzOjN|M{Kw
human SW480 cells M{\5fmZ2dmO2aX;uJIF{e2G7 M{OwTFQxKHSxIES4JIg> NHLufohKdmirYnn0bY9vKG:oIIThcot6emG|ZTDpckBpfW2jbjDTW|Q5OCClZXzsd{Bie3Onc4Pl[EBieyCmZXfyZYRifGmxbjDv[kBj\XSjIHPheIVvcW5iYX\0[ZIhPDBidH:gOFghcHK|LDDJR|UxRTBwMkWg{txO NFW3VVEzOzdyMUWxOy=>
human SW480 cells M1n5W2Z2dmO2aX;uJIF{e2G7 MYeyOEBp M1TV[GlvcGmkaYTpc44hd2ZidHHub5lz[XOnIHnuJIh2dWGwIGPXOFgxKGOnbHzzJIF{e2W|c3XkJIF{KGGlY4XteYxifGmxbjDv[kBigGmwMjDh[pRmeiB{NDDodpMh[nliSH;lZ4h{fCCmeXWtZoF{\WRibXX0bI9l MnzaNlM4ODF3MUe=
human HT29 cells M3zwV2Z2dmO2aX;uJIF{e2G7 NWDDcYFwOjRiaB?= M4To[WlvcGmkaYTpc44hd2ZiV370JJNq\26jbHnu[{BqdiCqdX3hckBJXDJ7IHPlcIx{KGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4Yh[mW2YT3jZZRmdmmwLX3l[IlifGWmIGTj[k9N\WZidILhcpNkemmydHnvcoFtKGGldHn2bZR6KGGodHXyJFI1KGi{czDifUBlfWGuIHz1Z4ln\XKjc3WgdoVxd3K2ZYKg[4Vv\SCjc4PhfUBz\WyjdHn2[UB1dyClb370do9tNCCLQ{WwQVI1NjRizszN MlPxNlQ6PTB2OEm=
human HT29 cells NUSxbpAyTnWwY4Tpc44h[XO|YYm= MUGyOUDPxE1? NHrERYwzPCCq M4OzbmlvcGmkaYTpc44hd2ZiV370JJNq\26jbHnu[{BqdiCqdX3hckBJXDJ7IHPlcIx{KGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4Yh[mW2YT3jZZRmdmmwLX3l[IlifGWmIGTj[k9N\WZidILhcpNkemmydHnvcoFtKGGldHn2bZR6KGG2IEK1JJVOKGGodHXyJFI1KGi{czDifUBlfWGuIHz1Z4ln\XKjc3WgdoVxd3K2ZYKg[4Vv\SCjc4PhfUBz\WyjdHn2[UB1dyClb370do9tKGmwIIDy[ZNmdmOnIH;mJGdUUy1|YnX0ZUBqdmirYnn0c5IhVGmFbB?= NYjubJJPOjR7NUC0PFk>
human DLD1 cells M4\DdmZ2dmO2aX;uJIF{e2G7 MYqyJIg> NYDzOpdHUW6mdXP0bY9vKG:oIFH4bY4zKHO2YXLpcIl7[XSrb36gbY4hcHWvYX6gSGxFOSClZXzsd{Bie3Onc4Pl[EBieyCmZXPy[YF{\WRidILhcpNkemmydHnvckBw\iCDeHnuNkBi\nSncjCyJIhzeyCkeTDSWE1RS1JibXX0bI9lNg>? MoHxNVkyOjVzNU[=
HEK293 cells MYrGeY5kfGmxbjDhd5NigQ>? MmnpSIl{eGyjY3Xt[Y51KG:oIFnXVk1RSiCocn;tJGF5cW5{IHnuJGhGUzJ7MzDj[YxteyCkeTDX[ZN1\XKwIHLsc5QhdWW2aH;k MkLINVkyOjVzNU[=

... Click to View More Cell Line Experimental Data

Protocol

Solubility (25°C)

In vitro DMSO 30 mg/mL (73.27 mM)
Water <1 mg/mL
Ethanol <1 mg/mL
In vivo

* 1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 409.44
Formula

C25H19N3O3

CAS No. 1127442-82-3
Storage powder
in solvent
Synonyms N/A

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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Wnt/beta-catenin Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID