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JAK Janus Kinase

JAK Inhibitors (18)

water-soluble

Cat.No. Product Name Information Product Citations Customer Reviews
S1378 Ruxolitinib (INCB018424) INCB018424 is a JAK family inhibitor for JAK1, JAK2 and JAK3 with IC50 of 2.7 nM, 4.5 nM and 322 nM, respectively.
S5001 Tofacitinib citrate (CP-690550 citrate) Tofacitinib citrate (CP-690550) is a potent JAK3 inhibitor with IC50 of 1 nM.
S2736 TG101348 (SAR302503) TG-101348 (SAR302503) is a selective inhibitor of JAK2 with IC50 of 3 nM.
S2789 Tofacitinib (CP-690550, Tasocitinib) CP-690550 is a novel inhibitor of JAK3 with IC50 of 1 nM.
S2162 AZD1480 AZD1480 is a novel ATP-competitive inhibitor of JAK1 and JAK2 with IC50 of 1.3 nM and 0.26 nM, respectively.
S1143 AG-490 AG-490 (Tyrphostin B42) is an inhibitor of EGFR, ErbB2 and JAK2 with IC50 of 0.1 μM, 13.5 μM, and ~10 μM, respectively.
S2219 Cyt387 CYT387 is an ATP-competitive inhibitor of JAK1 and JAK2 with IC50 of 11 nM and 18 nM, respectively.
S2686 NVP-BSK805 NVP-BSK805 is a potent and selective ATP-competitive JAK2 inhibitor with IC50 of 0.5 nM.
S2692 TG101209 TG101209 is a potent inhibitor of JAK2, Flt3 and RET with IC50 of 6 nM, 25 nM and 17 nM, respectively.
S2851 Baricitinib (LY3009104, INCB28050) Baricitinib is a selective JAK1 and JAK2 inhibitor with IC50 of 5.9 nM and 5.7 nM, respectively.
Cat.No. Product Name Information Product Citations Customer Reviews
S2796 WP1066 WP1066 is a novel inhibitor of JAK2 and STAT3 with IC50 of 2.30 μM and 2.43 μM in HEL cells .
S1134 AT9283 AT9283 is a potent pan-Aurora inhibitor for Aurora A, Aurora B, JAK3, JAK2 and Abl with IC50 of 3 nM, 3 nM, 1.1 nM, 1.2 nM and 4 nM, respectively.
S2806 CEP33779 CEP33779 is a selective JAK2 inhibitor with IC50 of 1.8 nM.
S2214 AZ 960 AZ 960 is a novel ATP competitive JAK2 inhibitor with IC50 and Ki of <3 nM and 0.45 nM, respectively.
S2867 WHI-P154 WHI-P154 is a potent JAK3 inhibitor with IC50 of 1.8 μM and also inhibits EGFR with IC50 of 4 nM.
S2179 LY2784544 LY2784544 is selective to V617F mutant JAK2 with IC50 of 55 nM in Ba/F3 cells.
S2902 S-Ruxolitinib S-Ruxolitinib is a JAK family inhibitor for JAK1 and JAK2 with IC50 of 3.3 nM and 2.8 nM, respectively.
S8004 ZM 39923 HCl ZM39923 is an JAK inhibitor for JAK1, JAK3, EFGR and TGM2 with IC50 of 4.4 μM, 7.1 μM, 5.6 μM and 10 nM, respectively.
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Tags: JAK inhibition | JAK pathway | JAK/stat pathway | JAK drugs | JAK activation | JAK assay | JAK cancer | JAK phosphorylation | JAK2 inhibitors clinical trials | JAK inhibitors in development | JAK2 inhibitor drug | JAK inhibitor review