Peficitinib (ASP015K, JNJ-54781532)
Catalog No.S7650

Molecular Weight(MW): 326.39
Peficitinib (ASP015K, JNJ-54781532) is an orally bioavailable JAK inhibitor. Phase 3.
Purity & Quality Control
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Biological Activity
Description | Peficitinib (ASP015K, JNJ-54781532) is an orally bioavailable JAK inhibitor. Phase 3. | |
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Targets |
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In vitro |
ASP015K suppresses the IL-2-induced proliferation of human T cells with greater potency than EPO-induced proliferation of human erythroleukemia cells. In human whole blood, ASP015K inhibits STAT5 phosphorylation (pSTAT5). [1] |
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In vivo | In the rat AIA model, ASP015K (p.o.) significantly decreases paw swelling and ankle bone destruction score. [1] |
Protocol
References
Solubility (25°C)
In vitro | DMSO | 65 mg/mL (199.14 mM) |
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Water | Insoluble | |
Ethanol | Insoluble |
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Chemical Information
Molecular Weight | 326.39 |
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Formula | C18H22N4O2 |
CAS No. | 944118-01-8 |
Storage | powder |
Synonyms | N/A |
Bio Calculators
Molarity Calculator
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Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.
Molarity Calculator
Clinical Trial Information
NCT Number | Recruitment | Conditions | Sponsor/Collaborators | Start Date | Phases |
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NCT02760342 | Completed | Healthy Subjects | Astellas Pharma Inc | May 2016 | Phase 1 |
NCT02586194 | Completed | Patients With Impaired Hepatic Function | Astellas Pharma Inc | November 2015 | Phase 1 |
NCT02603497 | Completed | Patients With Impaired Renal Function | Astellas Pharma Inc | November 2015 | Phase 1 |
NCT02531191 | Completed | Healthy Volunteers | Astellas Pharma Inc | June 2015 | Phase 1 |
NCT02305849 | Active, not recruiting | Rheumatoid Arthritis | Astellas Pharma Inc | July 2014 | Phase 3 |
NCT02308163 | Active, not recruiting | Rheumatoid Arthritis | Astellas Pharma Inc | July 2014 | Phase 3 |
Tech Support
Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.
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