Peficitinib (ASP015K, JNJ-54781532)

Catalog No.S7650

Peficitinib (ASP015K, JNJ-54781532) Chemical Structure

Molecular Weight(MW): 326.39

Peficitinib (ASP015K, JNJ-54781532) is an orally bioavailable JAK inhibitor. Phase 3.

Size Price Stock Quantity  
USD 147 In stock
USD 477 In stock
Bulk Discount

Free Overnight Delivery on orders over $ 500
Next day delivery by 10:00 a.m. Order now.

Purity & Quality Control

Choose Selective JAK Inhibitors

Biological Activity

Description Peficitinib (ASP015K, JNJ-54781532) is an orally bioavailable JAK inhibitor. Phase 3.
Targets
JAK [1]
In vitro

ASP015K suppresses the IL-2-induced proliferation of human T cells with greater potency than EPO-induced proliferation of human erythroleukemia cells. In human whole blood, ASP015K inhibits STAT5 phosphorylation (pSTAT5). [1]

In vivo In the rat AIA model, ASP015K (p.o.) significantly decreases paw swelling and ankle bone destruction score. [1]

Protocol

References

Solubility (25°C)

In vitro DMSO 65 mg/mL (199.14 mM)
Water Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 326.39
Formula

C18H22N4O2

CAS No. 944118-01-8
Storage powder
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02760342 Completed Healthy Subjects Astellas Pharma Inc May 2016 Phase 1
NCT02586194 Completed Patients With Impaired Hepatic Function Astellas Pharma Inc November 2015 Phase 1
NCT02603497 Completed Patients With Impaired Renal Function Astellas Pharma Inc November 2015 Phase 1
NCT02531191 Completed Healthy Volunteers Astellas Pharma Inc June 2015 Phase 1
NCT02305849 Active, not recruiting Rheumatoid Arthritis Astellas Pharma Inc July 2014 Phase 3
NCT02308163 Active, not recruiting Rheumatoid Arthritis Astellas Pharma Inc July 2014 Phase 3

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

Related Antibodies

JAK Signaling Pathway Map

Related JAK Products

Tags: buy Peficitinib (ASP015K, JNJ-54781532) | Peficitinib (ASP015K, JNJ-54781532) supplier | purchase Peficitinib (ASP015K, JNJ-54781532) | Peficitinib (ASP015K, JNJ-54781532) cost | Peficitinib (ASP015K, JNJ-54781532) manufacturer | order Peficitinib (ASP015K, JNJ-54781532) | Peficitinib (ASP015K, JNJ-54781532) distributor
×
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID