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P450 (e.g. CYP17)

Other Metabolism Related Inhibitors

Dehydrogenase Transferase DPP Aminopeptidase Procollagen C Proteinase Phospholipase (e.g. PLA) Factor Xa PDE DHFR Carbonic Anhydrase

Isoform-selective Products

P450 CYP2 CYP51 CYP3 CYP735 CYP11 CYP26 CYP2C9 CYP1 CYP17

Cat.No.	Product Name	Information	Product Use Citations	Product Validations
S2246	Abiraterone Acetate	Abiraterone Acetate is an acetate salt form of Abiraterone which is a steroidal cytochrome CYP17 inhibitor with IC50 of 72 nM in a cell-free assay. Abiraterone acetate is an oral androgen biosynthesis inhibitor.	Frontiers in Medicine, 2025 Dec 9, 1643506 Adv Sci (Weinh), 2025, 12(31):e01284 Cancer Med, 2025, 14(9):e70855
S2262	Apigenin	Apigenin is a potent P450 inhibitor for CYP2C9 with K_i of 2 μM.	Frontiers in Endocrinology, October 17, 2025, 1633584 International Journal of Clinical and Experimental Medicine, March 30, 2018, 1615-1631 Molecules, June 23, 2023, 4947
S1123	Abiraterone	Abiraterone is a potent CYP17 inhibitor with IC50 of 2 nM in a cell-free assay. This compound is an androgen biosynthesis inhibitor.	Molecular Cancer Research, October 2017, 1308-1317 Scientific Reports, May 24, 2021, 10765 Cancer Res, 2023, 83(8):1361-1380
S1442	Voriconazole	Voriconazole is a new triazole derivative similar to fluconazole and itraconazole that acts by inhibiting fungal cytochrome P-450-dependent, 14-alpha-sterol demethylase-mediated synthesis of ergosterol.	J Adv Res, 2025, S2090-1232(25)00065-7 PLoS Pathog, 2025, 21(5):e1013220 mSphere, 2025, 10(1):e0070324
S1257	Posaconazole	Posaconazole is an inhibitor primarily of CYP3A4, but it does not inhibit the activity of other CYP enzymes; Also an inhibitor of sterol C14ɑ demethylase inhibitor with IC50 of 0.25 μM. This compound has a median terminal elimination half-life of 15-35 hours.	Infect Drug Resist, 2025, 18:783-789 Front Cell Infect Microbiol, 2023, 13:1131641 Front Cell Infect Microbiol, 2022, 12:1074903
S1331	Fluconazole	Fluconazole is a fungal lanosterol 14 alpha-demethylase inhibitor, which thereby prevents the formation of ergosterol, used in the treatment and prevention of superficial and systemic fungal infections.	International Journal of Molecular Sciences, November 09, 2022, 13809 Antimicrobial Agents and Chemotherapy, March 24, 2025, e01662-25 Frontiers in Cellular and Infection Microbiology, January 17, 2024, 1296151
S2268	Baicalein	Baicalein is a CYP2C9 and prolyl endopeptidase inhibitor.	SLAS Discov, 2024, S2472-5552(24)00007-8 Redox Rep, 2023, 28(1):2152607 Microbiol Spectr, 2023, 11(3):e0470222
S1353	Ketoconazole	Ketoconazole inhibits cyclosporine oxidase and testosterone 6 beta-hydroxylase with IC50 of 0.19 mM and 0.22 mM, respectively. This compound is an androgen biosynthesis inhibitor.	Nature, 2025, 10.1038/s41586-025-09755-9 Mol Oncol, 2025, 10.1002/1878-0261.13799 Discov Oncol, 2024, 15(1):709
S1712	Deferasirox (ICL670)	Deferasirox is an iron chelator, also a cytochrome P450 3A4 inducer, Cytochrome P450 2C8 inhibitor, and Cytochrome P450 1A2 inhibitor. Deferasirox-induced iron depletion promotes BclxL downregulation and cell death.	Front Immunol, 2025, 16:1502094 Elife, 2023, 12RP88745 J Transl Med, 2023, 21(1):50
S2046	Pioglitazone HCl	Pioglitazone HCl (AD-4833, U-72107E) is an inhibitor of cytochrome P450 (CYP)2C8 and CYP3A4 enzymes. This compound inhibits CYP2C8, CYP3A4 and CYP2C9 with Ki of 1.7 μM, 11.8 μM and 32.1 μM, respectively. It is also a selective peroxisome proliferator-activated receptor-gamma (PPARγ) agonist with EC50 of 0.93 μM and 0.99 μM for human PPARγ and mouse PPARγ, respectively. This chemical inhibits mitochondrial iron uptake, lipid peroxidation, and subsequent ferroptosis.	J Transl Med, 2024, 22(1):593 The Journal of Clinical Endocrinology & Metabolism, 2024, 2579-2588 Commun Biol, 2022, 5(1):231
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