Research Area
Product Type
United States ( Change Country )
SNX-2112 Chemical Structure
Recommended Products
Elesclomol
HSP-70 Inducer
AUY922 (NVP-AUY922)
NVP-AUY922 (VER-52296) is a highly potent HSP90 inhibitor to HSP90α and HSP90β with IC50 of 13 nM and 21 nM, respectively.
17-AAG (Geldanamycin)
17-AAG (Geldanamycin) is a less toxic analogue of the geldanamycin which binds to Hsp90 and alters its function.
17-DMAG HCl (Alvespimycin)
17-DMAG HCl (Alvespimycin) is a selective Hsp90 inhibitor with a GI50 of 53 nM.
Ganetespib (STA-9090)
Ganetespib is a unique triazolone-containing Hsp90 inhibitor with an IC50 of 4 nM for OSA 8 cells.
AT13387
AT13387 is a selective potent small molecule heat shock protein 90 (Hsp90) inhibitor for A375, MV4-11, NCI-H1975 and SKBr3 cell lines with IC50 of 18 nM, 12 nM, 22 nM and 55 nM, respectively.
BIIB021
BIIB021 is an inhibitor of Hsp90(Ki=1.7nM).
MPC-3100
MPC-3100 is a fully synthetic potent small-molecule Hsp90 inhibitor with an IC50 of 60 nM.
NVP-BEP800
NVP-BEP800 is a novel, fully synthetic, oral Hsp90 inhibitor with an IC50 of 0.058 ± 0.006 μM.
PF-04929113 (SNX-5422)
PF-04929113 (SNX-5422) is a potent and selective Hsp90 inhibitor with an IC50 of median 50 nM.
Biological Activity
SNX-2112 is a potent synthetic heat shock protein 90 inhibitor with an IC50 of 0.92 μM for K562 cells. The heat shock protein 90 (Hsp90) chaperone not only regulates the conformational maturation but also stables the structures of oncogenic kinases as well as transcription factors. SNX-2112 is an active metabolite of the compounds SNX-5542. SNX-2112 is rapidly transformed form SNX-5542 after administration. In a panel of tumor cell lines, SNX-2112 degraded HER2 and mutant epidermal growth factor receptor and inhibited extracellular signal-modulated kinase and Akt activation.SNX-2112 inducen a Rb-dependent G1 arrest with subsequent apoptosis. which accumulates in tumors relative to normal tissues. [1][2]
References on SNX-2112
- [1] Blood. 2009 Jan 22;113(4):846-55.
- [2] Clin Cancer Res. 17(1):122-33.;2011 Jan 1
Chemical Information
| Molecular Weight (WM): | 464.48 |
|---|---|
| Formula: | C23H27F3N4O3 |
| CAS No.: | 908112-43-6 |
| Synonyms: |
N/A
|
| Dissolve in (25°C): | DMSO ≥93mg/mL |
| Water <1mg/mL | |
| Ethanol ≥2mg/mL | |
| Storage: | 2 years-20°CPowder |
| 1 week-4°Cin DMSO | |
| 1 month-80°in DMSO |
Quality Control & MSDS
Research Area
Related Inhibitors
Recommended Screening Libraries
Chemical Library
A collection of 864 bioactive compounds
Inhibitor Library
A collection of 481 inhibitors
Kinase Inhibitor Library
A collection of 194 kinase inhibitors
Tyrosine Kinase Inhibitor Library
A collection of 85 tyrosine kinase inhibitors.
FDA Approved Drug Library
A collection of 426 FDA approved drugs
Natural Product Library
A collection of 139 natural products
Chemotherapeutic Agent Library
A collection of 40 chemotherapeutic agents
Epigenetics Compound library
A unique collection of 17 small molecule modulators
Stem Cell Compound library
A unique collection of 47 small molecule inhibitors
GPCR Compound library
A unique collection of 63 GPCR small molecules
Keywords:buy SNX-2112 | SNX-2112 supplier | purchase SNX-2112 | SNX-2112 cost | SNX-2112 manufacturer | order SNX-2112 | SNX-2112 distributor