Luminespib (AUY-922, NVP-AUY922)

Catalog No.S1069 Synonyms: VER-52296

Luminespib (AUY-922, NVP-AUY922) Chemical Structure

Molecular Weight(MW): 465.54

Luminespib (AUY-922, NVP-AUY922) is a highly potent HSP90 inhibitor for HSP90α/β with IC50 of 13 nM /21 nM in cell-free assays, weaker potency against the HSP90 family members GRP94 and TRAP-1, exhibits the tightest binding of any small-molecule HSP90 ligand. Phase 2.

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In DMSO USD 320 In stock
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3 Customer Reviews

  • U2OS_exo cells were incubated with AUY922 for 20 h at the indicated concentrations before stimulation with TNFα (30 ng/mL) for 30 min and immunostaining to detect NF-κB (p65). DMSO 1%, cells stimulated by TNFα in the absence of AUY922. Representative pictures used to quantify nuclear and cytoplasmic localization of NF-κB.

    Proc Natl Acad Sci USA, 2014, 111(15): E1528–37 . Luminespib (AUY-922, NVP-AUY922) purchased from Selleck.

    J Biol Chem 2013 288(23), 16308-20. Luminespib (AUY-922, NVP-AUY922) purchased from Selleck.

  • Western blots show the molecular signature of HSP90 inhibition by NVP-AUY922  (ie, induction of HSP72 and depletion of client proteins such as ERBB2, CRAF and CDK4) in BT474 breast cancer cell line. GAPDH was used as loading control.

     

     

    2011 Dr. Swee Sharp and Professor Paul Workman from Cancer Research UK. Luminespib (AUY-922, NVP-AUY922) purchased from Selleck.

Purity & Quality Control

Choose Selective HSP (e.g. HSP90) Inhibitors

Biological Activity

Description Luminespib (AUY-922, NVP-AUY922) is a highly potent HSP90 inhibitor for HSP90α/β with IC50 of 13 nM /21 nM in cell-free assays, weaker potency against the HSP90 family members GRP94 and TRAP-1, exhibits the tightest binding of any small-molecule HSP90 ligand. Phase 2.
Targets
HSP90α [1]
(Cell-free assay)
HSP90β [1]
(Cell-free assay)
13 nM 21 nM
In vitro

NVP-AUY922 inhibits proliferation of various human cancer cell lines in vitro, with an average GI50 of 9 nM. [1] The IC50 values of NVP-AUY922 fall in the range of 2 to 40 nM in these gastric cancer cell lines. IC50 value for the BEAS-2B cells is 28.49 nM. Treatment with NVP-AUY922 does not influence the expression of HSP90, but expression of HSP70 gets elevated by NVP-AUY922 treatment. NVP-AUY922 increases the binding of HSP70 to HSP90. NVP-AUY922 causes p23 dissociation from the HSP90 complex and can then recruit HSP70 to the HSP90 complex. [1] After the treatment with NVP-AUY922, expression of receptor tyrosine kinases including VEGFR1, 2, 3 and PDGFRɑ is decreased. A decrease is also noticed in the expression of Akt and phospho-Akt. Meanwhile, treatment with NVP-AUY922 causes decreased expression of HER-2 in NCI-N87 cells. NVP-AUY922 treatment results in binding of HSP90 to client proteins and setting them up as targets for degradation by the proteasome. NVP-AUY922 can influence cell growth by affecting multiple signaling pathways. In addition, treatment with the proteasome inhibitor, MG132, restores expression of thymidylate synthase, which is decreased by NVP-AUY922. NVP-AUY922 increases the expression of cleaved caspase-3 leading to apoptosis in HSC-2 cells.[1]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
CMK NXnOS5l2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUjWbogxUUN3ME2wMlAxODF{NTFOwG0> Mm\lV2FPT0WU
MV-4-11 NGi1ZZZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MormTWM2OD1yLkCwNFU2QCEQvF2= NXPaeI8{W0GQR1XS
NALM-6 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUHJR|UxRTBwMECwPFQzKM7:TR?= NIT3N|RUSU6JRWK=
HOS M1zDTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1nrPWlEPTB;MD6wNFE{QCEQvF2= NXOzUFFmW0GQR1XS
HT-144 Moe0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4XqSWlEPTB;MD6wNFE2PSEQvF2= M1nkO3NCVkeHUh?=
SW1710 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXnXd3N1UUN3ME2wMlAxOTh4IN88US=> MUfTRW5ITVJ?
TE-8 M3TBNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3XkR2lEPTB;MD6wNFI{PyEQvF2= M1HzOHNCVkeHUh?=
ES1 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHr3R5BKSzVyPUCuNFAzPjZizszN NXfzZ2l2W0GQR1XS
CCF-STTG1 NFq4[HpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlrSTWM2OD1yLkCwNlk4KM7:TR?= M{T2OXNCVkeHUh?=
PSN1 M{nEOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkLwTWM2OD1yLkCwN|E5KM7:TR?= M4rKZ3NCVkeHUh?=
CAL-51 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGXrO5RKSzVyPUCuNFA{OjVizszN MVLTRW5ITVJ?
MCF7 NFnoVopIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFnHOVhKSzVyPUCuNFA{OzVizszN MUjTRW5ITVJ?
SK-HEP-1 NGfBcWxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYDJR|UxRTBwMECzN|Yh|ryP NXfn[HdEW0GQR1XS
LCLC-103H NGj0PXBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXzre5ZSUUN3ME2wMlAxPDNizszN Ml;6V2FPT0WU
HMV-II NVnSfXk3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUPJR|UxRTBwMEC0OFkh|ryP MlzuV2FPT0WU
MES-SA MoDrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXvJR|UxRTBwMEC0OVIh|ryP NHOxR4xUSU6JRWK=
SK-LMS-1 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3jBbGlEPTB;MD6wNFQ2QCEQvF2= NYHC[|d6W0GQR1XS
639-V NFOyXnpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYjRZ3dUUUN3ME2wMlAxPDh3IN88US=> M{fJOXNCVkeHUh?=
SIG-M5 NYmz[5ZwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXTrR2RXUUN3ME2wMlAxPDh7IN88US=> NIexRY9USU6JRWK=
LOUCY Ml7nS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXK3fZJHUUN3ME2wMlAxPTB3IN88US=> MlrWV2FPT0WU
HSC-2 MkT4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXfJR|UxRTBwMEC1NVgh|ryP M1jwNHNCVkeHUh?=
EW-13 NEP4foxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NID0SIRKSzVyPUCuNFA2OThizszN M2GycnNCVkeHUh?=
RT-112 NWPlSI5qT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWXJR|UxRTBwMEC1N|Uh|ryP M2\PbHNCVkeHUh?=
NKM-1 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF;pWoNKSzVyPUCuNFA2PDdizszN Mk\5V2FPT0WU
KYSE-180 NGDGN|FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3zY[GlEPTB;MD6wNFU5PiEQvF2= MWHTRW5ITVJ?
SW1783 MkXaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVH3d41qUUN3ME2wMlAxPTlzIN88US=> NWjYNGRjW0GQR1XS
A431 NH;1b45Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXHyTW9KUUN3ME2wMlAxPjB5IN88US=> NIj6cIdUSU6JRWK=
SK-OV-3 NYXscmExT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYjJR|UxRTBwMEC2N{DPxE1? MnPXV2FPT0WU
RPMI-7951 NIDnfJhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGHWO5dKSzVyPUCuNFA3OzFizszN MkjxV2FPT0WU
Capan-2 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mlq5TWM2OD1yLkCwOlM5KM7:TR?= MVfTRW5ITVJ?
HSC-3 NHTxSYJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlvGTWM2OD1yLkCwOlQyKM7:TR?= MWLTRW5ITVJ?
786-0 NUezW2RqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmD6TWM2OD1yLkCwOlY{KM7:TR?= M3L4O3NCVkeHUh?=
Daoy NGnXRW5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXzJR|UxRTBwMEC2PVUh|ryP MVLTRW5ITVJ?
KGN NHjTVndIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUftWZc6UUN3ME2wMlAxPzB|IN88US=> M4PyU3NCVkeHUh?=
EW-16 NX21Xlc4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4K4U2lEPTB;MD6wNFc1QSEQvF2= M2nXbnNCVkeHUh?=
EW-7 MmnUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH36blBKSzVyPUCuNFA4PTRizszN NHL2cXlUSU6JRWK=
IGROV-1 NEXFPHNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MljnTWM2OD1yLkCwPFE1KM7:TR?= NFjRdW5USU6JRWK=
8505C MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYiyfFBoUUN3ME2wMlAxQDJzIN88US=> Ml70V2FPT0WU
RKO M1TDXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUXJR|UxRTBwMEC4NlYh|ryP MVfTRW5ITVJ?
GDM-1 MnfDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkPUTWM2OD1yLkCwPFQh|ryP M{O0e3NCVkeHUh?=
IST-MEL1 M{HjVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{TWemlEPTB;MD6wNFg2OiEQvF2= M3z5eHNCVkeHUh?=
RPMI-6666 NHTMNXRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH7MXGlKSzVyPUCuNFA5PTJizszN MnXpV2FPT0WU
SNG-M NInLVXBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFfyR49KSzVyPUCuNFA5PTZizszN NI[2e3JUSU6JRWK=
KS-1 MoC1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWPJR|UxRTBwMEC4OVkh|ryP MUjTRW5ITVJ?
RXF393 NXLvboVmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXLJR|UxRTBwMEC4OkDPxE1? M4LQXHNCVkeHUh?=
CAL-12T NH7RUZZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXTGcmN3UUN3ME2wMlAxQTJ{IN88US=> M4\sUHNCVkeHUh?=
BFTC-905 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV\i[lB7UUN3ME2wMlAxQTN6IN88US=> NELy[GNUSU6JRWK=
SK-MES-1 NXW3VGNkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHy2[2NKSzVyPUCuNFA6PDVizszN NY\0PFFYW0GQR1XS
BB30-HNC MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1ixRWlEPTB;MD6wNFk2OiEQvF2= NH3lcmNUSU6JRWK=
AN3-CA MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWTJR|UxRTBwMEGwNVch|ryP NYWyOZFIW0GQR1XS
EFO-27 M4rZVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYH5RndkUUN3ME2wMlAyODF5IN88US=> NUPaO5BWW0GQR1XS
G-401 NHW1XZRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFnEVWdKSzVyPUCuNFExOjVizszN NULiZVBZW0GQR1XS
BPH-1 M4nkVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mm\BTWM2OD1yLkCxNFMh|ryP MVzTRW5ITVJ?
NCI-H727 M2nlUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnrNTWM2OD1yLkCxNFMh|ryP NIXCblhUSU6JRWK=
SNU-423 NXjzUZR1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml7RTWM2OD1yLkCxNFU{KM7:TR?= NUfNOmg1W0GQR1XS
KYSE-270 NHLIbJFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWXQ[mlQUUN3ME2wMlAyODV7IN88US=> MW\TRW5ITVJ?
AGS NUDuXHhPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3HrVGlEPTB;MD6wNVA3OSEQvF2= NWP5b|Z4W0GQR1XS
NCI-H2228 NUWyPFlHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4HycWlEPTB;MD6wNVA3PCEQvF2= M4rLXHNCVkeHUh?=
SW954 M{jOV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2XIfmlEPTB;MD6wNVA4OSEQvF2= Mn7qV2FPT0WU
769-P NUXNS4ZVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXTKXIZxUUN3ME2wMlAyODd|IN88US=> NGm2e2VUSU6JRWK=
BB49-HNC NGTKV25Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXTJR|UxRTBwMEGwO|ch|ryP Mmn3V2FPT0WU
IA-LM NX3DfYFkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUHJR|UxRTBwMEGwPFYh|ryP M1\4fnNCVkeHUh?=
NB69 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFzydo9KSzVyPUCuNFEyODJizszN Ml\nV2FPT0WU
C8166 NYLPT3ZnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHX6VYNKSzVyPUCuNFEyOjlizszN MofUV2FPT0WU
NCI-H1299 Mn3GS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX3OZmc1UUN3ME2wMlAyOTV2IN88US=> M{fGO3NCVkeHUh?=
YKG-1 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mm\XTWM2OD1yLkCxNVYh|ryP MULTRW5ITVJ?
PANC-03-27 NFXHenNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYDkSmJ1UUN3ME2wMlAyOTZ{IN88US=> NVHBT4VtW0GQR1XS
YT M3PST2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIPEPXZKSzVyPUCuNFEyPzlizszN M4DMT3NCVkeHUh?=
CAL-85-1 M4q0PGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4\Xe2lEPTB;MD6wNVE6OiEQvF2= MVXTRW5ITVJ?
GT3TKB NFX3c|lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGK3V4JKSzVyPUCuNFEzODJizszN NXrIZpYyW0GQR1XS
BB65-RCC MmXHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3jHU2lEPTB;MD6wNVIxPCEQvF2= M{nyd3NCVkeHUh?=
ES6 M{\iXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlnrTWM2OD1yLkCxNlYyKM7:TR?= MoDwV2FPT0WU
MHH-ES-1 NF;tclJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYXORWpEUUN3ME2wMlAyOjZ|IN88US=> M1zyUHNCVkeHUh?=
QIMR-WIL MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXnJR|UxRTBwMEGyOlkh|ryP NU\ocXNzW0GQR1XS
SNU-C2B NHPZeYRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV7vZ5dqUUN3ME2wMlAyOjd{IN88US=> NYXNdok1W0GQR1XS
OCI-AML2 M332[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mk\qTWM2OD1yLkCxNlgyKM7:TR?= Mn7SV2FPT0WU
DU-145 M3vLbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmjzTWM2OD1yLkCxNlkh|ryP Mn\UV2FPT0WU
SW982 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEDaPHZKSzVyPUCuNFEzQTNizszN NGrsS2ZUSU6JRWK=
MFH-ino M3[zZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NE[yZVBKSzVyPUCuNFEzQTNizszN MX7TRW5ITVJ?
A427 NGHNOFNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWrKbVUyUUN3ME2wMlAyOjl7IN88US=> MYTTRW5ITVJ?
LCLC-97TM1 NVrVbYg1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX;5NnVVUUN3ME2wMlAyOyEQvF2= M4rkeHNCVkeHUh?=
AM-38 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWfJR|UxRTBwMEGzNFIh|ryP MUfTRW5ITVJ?
K5 Mn3LS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWPVWVVQUUN3ME2wMlAyOzB6IN88US=> NYjjc4tQW0GQR1XS
T84 NWnR[4ZiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGPie4xKSzVyPUCuNFE{OzFizszN MoiwV2FPT0WU
TE-15 Mnr5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mm\VTWM2OD1yLkCxN|M3KM7:TR?= NFXveWFUSU6JRWK=
NCI-H460 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVn5eo57UUN3ME2wMlAyOzN4IN88US=> M13HSnNCVkeHUh?=
NTERA-S-cl-D1 NHLXOllIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlzpTWM2OD1yLkCxN|M6KM7:TR?= NGTodY5USU6JRWK=
KYSE-450 M1j2c2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWrJR|UxRTBwMEGzOFkh|ryP M1;mWXNCVkeHUh?=
H4 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV62NHcxUUN3ME2wMlAyOzZ4IN88US=> NWDzd|VxW0GQR1XS
LC-2-ad NFPnXVlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWLxXVFYUUN3ME2wMlAyOzdizszN MlLBV2FPT0WU
GAMG MnjrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF3TWINKSzVyPUCuNFE{PzFizszN NGrHS3ZUSU6JRWK=
TK10 M{DjRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXXOOlFwUUN3ME2wMlAyOzh{IN88US=> MWTTRW5ITVJ?
NCI-H2122 NGD3Om1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3\MdWlEPTB;MD6wNVM5PCEQvF2= M3fTOHNCVkeHUh?=
KM12 MoXDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4D5SmlEPTB;MD6wNVM6QSEQvF2= NFfPc2pUSU6JRWK=
CAL-39 Mlq5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1vYOmlEPTB;MD6wNVQzKM7:TR?= M4fGRXNCVkeHUh?=
RPMI-2650 MorNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1m1OWlEPTB;MD6wNVQ{OiEQvF2= MV3TRW5ITVJ?
KYSE-510 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGnjSFFKSzVyPUCuNFE1PDJizszN MY\TRW5ITVJ?
KALS-1 Mk\lS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXHJR|UxRTBwMEG0OlYh|ryP NIDVUpRUSU6JRWK=
NCI-H1648 Mlr5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF7SV|BKSzVyPUCuNFE1QTlizszN NGHGVZdUSU6JRWK=
ES4 M{fWe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVjz[FVDUUN3ME2wMlAyPTB{IN88US=> NFX2WolUSU6JRWK=
C-33-A NH;BRWNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MniwTWM2OD1yLkCxOVA6KM7:TR?= M3vrU3NCVkeHUh?=
MIA-PaCa-2 MljIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mk\2TWM2OD1yLkCxOVA6KM7:TR?= NGO0ZZNUSU6JRWK=
Becker NH7HbG9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkXITWM2OD1yLkCxOVE1KM7:TR?= M2qwZnNCVkeHUh?=
HOP-62 M{PFW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MY\JR|UxRTBwMEG1OFIh|ryP NEmwWllUSU6JRWK=
TE-1 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4PMS2lEPTB;MD6wNVU5OSEQvF2= NIXPUppUSU6JRWK=
KYSE-410 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHvLdVZKSzVyPUCuNFE2QDZizszN MXPTRW5ITVJ?
NOS-1 NEfXXYtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWTJR|UxRTBwMEG1PVMh|ryP NFfVNo5USU6JRWK=
MEL-HO NEnoUXFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHPlfmlKSzVyPUCuNFE3PDNizszN MnrPV2FPT0WU
NCI-H1650 NHfNTFNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYPUNpJ6UUN3ME2wMlAyPjR4IN88US=> MVLTRW5ITVJ?
VMRC-RCZ NUPsNIpFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{HsdWlEPTB;MD6wNVY2OSEQvF2= NVntTFRuW0GQR1XS
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JiyoyeP-2003 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYLJR|UxRTBwMEOzPFgh|ryP NGjVZmNUSU6JRWK=
BL-70 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVrPXGlTUUN3ME2wMlA{Ozh7IN88US=> NGPIOGtUSU6JRWK=
OS-RC-2 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn:yTWM2OD1yLkCzN|k3KM7:TR?= MmfmV2FPT0WU
SF268 NIT6UnBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV3JR|UxRTBwMEO0NFEh|ryP Mn3jV2FPT0WU
BV-173 NFn4VohIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIT5eHZKSzVyPUCuNFM1OjZizszN MUTTRW5ITVJ?
DMS-273 M3LQVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3nvUWlEPTB;MD6wN|Q4QSEQvF2= NEfGRXdUSU6JRWK=
22RV1 M2PEOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3nPRmlEPTB;MD6wN|UxPyEQvF2= M3Tjd3NCVkeHUh?=
ES8 NVTQN3d1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYLJR|UxRTBwMEO1N|gh|ryP M3vidnNCVkeHUh?=
KYSE-150 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3ThbGlEPTB;MD6wN|YxQCEQvF2= M3HSbXNCVkeHUh?=
HCC1569 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV\UZWhZUUN3ME2wMlA{PjB6IN88US=> Mon6V2FPT0WU
NB5 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVjJR|UxRTBwMEO2NVMh|ryP NYS3eVNGW0GQR1XS
G-402 Mn7qS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF\sdYFKSzVyPUCuNFM3OTRizszN NFzaOYpUSU6JRWK=
NCI-H1693 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlHOTWM2OD1yLkCzOlE4KM7:TR?= Mln3V2FPT0WU
LB2241-RCC MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXL2NlhtUUN3ME2wMlA{PjR{IN88US=> MorlV2FPT0WU
KP-4 Ml;mS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mm\CTWM2OD1yLkCzOlY{KM7:TR?= M{XsVnNCVkeHUh?=
ML-2 M4C1VGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4njcGlEPTB;MD6wN|Y4OSEQvF2= NUTROJZrW0GQR1XS
KU812 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlLGTWM2OD1yLkCzOlg1KM7:TR?= NFjKSHpUSU6JRWK=
LS-411N M2DkbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkTUTWM2OD1yLkCzO|MyKM7:TR?= NGXwSYpUSU6JRWK=
OAW-42 MkfvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUK5[XF[UUN3ME2wMlA{PzR5IN88US=> M3ftNnNCVkeHUh?=
HCC38 NG[zfWNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHvoSo1KSzVyPUCuNFM4PzFizszN NEfQOlFUSU6JRWK=
Ca-Ski NEjKbZlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M133OWlEPTB;MD6wN|c5PCEQvF2= NHLGSYNUSU6JRWK=
Calu-3 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVzJR|UxRTBwMEO3PFkh|ryP NEfOV|RUSU6JRWK=
KYSE-70 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnT4TWM2OD1yLkCzPFEzKM7:TR?= NIqzZVFUSU6JRWK=
D-392MG NFvUdFVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWHJR|UxRTBwMEO4OFIh|ryP MXvTRW5ITVJ?
OVCAR-4 NGjyW|BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlHKTWM2OD1yLkCzPFU5KM7:TR?= NUXyemZqW0GQR1XS
Detroit562 M3rtfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGDMTXZKSzVyPUCuNFM5PzJizszN MYDTRW5ITVJ?
HEL MnvHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NE\iS2VKSzVyPUCuNFM5QTFizszN NV7TdW5QW0GQR1XS
MONO-MAC-6 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWHPZ4RkUUN3ME2wMlA{QDl|IN88US=> M33FNnNCVkeHUh?=
LoVo MlLvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M362PWlEPTB;MD6wN|k{OyEQvF2= MVjTRW5ITVJ?
U-2-OS MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUnJR|UxRTBwMEO5N|Uh|ryP MYXTRW5ITVJ?
A172 M2L1TGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV;JR|UxRTBwMEO5OUDPxE1? NEfadZZUSU6JRWK=
OCUB-M MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M332SWlEPTB;MD6wN|k3OSEQvF2= NYfafm0{W0GQR1XS
SW48 NHPNdVVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVrwRZRqUUN3ME2wMlA1ODNzIN88US=> M3;T[HNCVkeHUh?=
HC-1 M2rtVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVXnWZdTUUN3ME2wMlA1ODZ7IN88US=> MYrTRW5ITVJ?
KOSC-2 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWrJR|UxRTBwMESxNUDPxE1? M1rGbXNCVkeHUh?=
HDLM-2 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn:5TWM2OD1yLkC0NVE1KM7:TR?= NHW4To9USU6JRWK=
CTV-1 NGfa[JhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGr6e3BKSzVyPUCuNFQyOTZizszN MkTzV2FPT0WU
SH-4 NILk[ZZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1fyTGlEPTB;MD6wOFE1OSEQvF2= NHfiToxUSU6JRWK=
SW756 M3z2Vmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYrJR|UxRTBwMESxOVch|ryP MXzTRW5ITVJ?
GCT NGP1SGdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MljuTWM2OD1yLkC0NVYyKM7:TR?= MX\TRW5ITVJ?
CHL-1 MmHuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGDyOJJKSzVyPUCuNFQyPjlizszN M3\5dnNCVkeHUh?=
LAMA-84 MnXxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXmxUJpNUUN3ME2wMlA1OTdzIN88US=> MlrrV2FPT0WU
LS-1034 NUDROo9sT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYjHXIhvUUN3ME2wMlA1OTlzIN88US=> NYTCSWlmW0GQR1XS
NCI-H358 M4P4dGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEHzZ3RKSzVyPUCuNFQzOTJizszN NWTnNYZLW0GQR1XS
NB13 NI\VZm1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUPJR|UxRTBwMESyNlch|ryP NWrC[24{W0GQR1XS
TE-9 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYHnWJFDUUN3ME2wMlA1OjN5IN88US=> NHnuSJpUSU6JRWK=
OE33 MkP3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV3JR|UxRTBwMESyOFEh|ryP Mk\LV2FPT0WU
CAL-120 NWPQcVhFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoH6TWM2OD1yLkC0NlQyKM7:TR?= MnvwV2FPT0WU
DJM-1 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVLJR|UxRTBwMESyO|Ih|ryP MXXTRW5ITVJ?
SK-MEL-24 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1jtbWlEPTB;MD6wOFI5OyEQvF2= NFnDcIxUSU6JRWK=
VA-ES-BJ MmDHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVjJR|UxRTBwMESyPVIh|ryP NEW4UYZUSU6JRWK=
MMAC-SF M2LE[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUTBWWl3UUN3ME2wMlA1Ojl5IN88US=> MnrXV2FPT0WU
MZ7-mel MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mk\FTWM2OD1yLkC0N|Mh|ryP NWPuboY6W0GQR1XS
BxPC-3 MlfhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4G1dWlEPTB;MD6wOFM1OSEQvF2= NIHETJVUSU6JRWK=
HT-29 NVHod4FOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3XX[mlEPTB;MD6wOFM2PyEQvF2= MWLTRW5ITVJ?
SK-MEL-30 NGj6cXVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnPlTWM2OD1yLkC0N|YzKM7:TR?= NGLJSJRUSU6JRWK=
CAL-33 NVW3cJZZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MofhTWM2OD1yLkC0N|c2KM7:TR?= NFvN[I1USU6JRWK=
COLO-680N M4nSRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3X0O2lEPTB;MD6wOFQxPyEQvF2= NITLT|NUSU6JRWK=
NH-12 Mmm0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXvJR|UxRTBwMES0OEDPxE1? NEj0ToxUSU6JRWK=
HCC1937 NYT6UoxiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYfPN4cxUUN3ME2wMlA1PDV4IN88US=> NEjB[3VUSU6JRWK=
IMR-5 Ml3IS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3jvRmlEPTB;MD6wOFQ6KM7:TR?= Ml;RV2FPT0WU
MC-CAR MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmrQTWM2OD1yLkC0OVY6KM7:TR?= MmfVV2FPT0WU
NCI-H747 NFzYXGpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoGwTWM2OD1yLkC0OVch|ryP NUPQdpBpW0GQR1XS
NCI-H1792 MnLrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoH0TWM2OD1yLkC0OVgyKM7:TR?= NUHjW5lHW0GQR1XS
SW13 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX\JR|UxRTBwMES1PUDPxE1? MlLYV2FPT0WU
MLMA MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Moq3TWM2OD1yLkC0OlA6KM7:TR?= MmTiV2FPT0WU
U251 NWLRNIlzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4HZSmlEPTB;MD6wOFc3OyEQvF2= MXPTRW5ITVJ?
U031 MnLFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3GwbmlEPTB;MD6wOFc4OSEQvF2= NHHuZpBUSU6JRWK=
ME-180 Ml:yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MonETWM2OD1yLkC0O|gzKM7:TR?= M{fDN3NCVkeHUh?=
SK-MEL-3 M4XOTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX\JR|UxRTBwMES4NFIh|ryP MXfTRW5ITVJ?
MOLT-4 NXzLVG9xT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXnJR|UxRTBwMES4NFMh|ryP NVu0UYtjW0GQR1XS
PF-382 NYLmUZRFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVPDSZY3UUN3ME2wMlA1QDJ4IN88US=> MXLTRW5ITVJ?
NUGC-3 NG\sSm5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVe1dIhvUUN3ME2wMlA1QDJ5IN88US=> MoTnV2FPT0WU
NCI-H1417 NGrMXGVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV;JR|UxRTBwMES4PUDPxE1? NHLOVGFUSU6JRWK=
COLO-205 NEjjPXZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHHnSpdKSzVyPUCuNFQ6OTlizszN NHXHeYFUSU6JRWK=
TE-441-T NIrsV21Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIrOcphKSzVyPUCuNFQ6OyEQvF2= M4TCfnNCVkeHUh?=
MKN1 NHHKVYVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmXJTWM2OD1yLkC0PVMh|ryP MVjTRW5ITVJ?
UM-UC-3 Ml72S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX;JR|UxRTBwMES5OUDPxE1? M17Wb3NCVkeHUh?=
SF126 NITYVnpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmrDTWM2OD1yLkC1NFEh|ryP M3HJVXNCVkeHUh?=
LB1047-RCC MkS0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NISyVY9KSzVyPUCuNFUxOzFizszN MmGxV2FPT0WU
A253 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoLCTWM2OD1yLkC1NFUzKM7:TR?= Mo\YV2FPT0WU
NCI-H1963 M2fERWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYryXZF1UUN3ME2wMlA2OTd4IN88US=> NVOwNXJTW0GQR1XS
VM-CUB-1 NUnoWnd1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUjIdVNXUUN3ME2wMlA2OzFzIN88US=> NHLqWHVUSU6JRWK=
T-24 NXvQSVZnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXTrcWVzUUN3ME2wMlA2Ozh2IN88US=> MWLTRW5ITVJ?
K-562 NVG2[GtET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1[2R2lEPTB;MD6wOVM5PyEQvF2= M33TbHNCVkeHUh?=
ARH-77 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGLM[mdKSzVyPUCuNFU{QTVizszN NFW0OFJUSU6JRWK=
CA46 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NE\reHZKSzVyPUCuNFU1OyEQvF2= NEPZPW1USU6JRWK=
HCC70 NUXhfmRUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYXpWGJzUUN3ME2wMlA2PDV{IN88US=> MUfTRW5ITVJ?
ST486 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFXzSXVKSzVyPUCuNFU2OjVizszN NVjZc3VIW0GQR1XS
COLO-741 M2T1[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYLJR|UxRTBwMEW1N|Eh|ryP MnnUV2FPT0WU
SK-PN-DW NUDCT4R5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlPQTWM2OD1yLkC1OVg5KM7:TR?= Mo\QV2FPT0WU
BL-41 MnLNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlLmTWM2OD1yLkC1OVk3KM7:TR?= NYG3N2NHW0GQR1XS
D-263MG NWnyT5F1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVO0eIlEUUN3ME2wMlA2Pjh|IN88US=> NYHPd5dJW0GQR1XS
KE-37 MlTTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWDJR|UxRTBwMEW2PFMh|ryP M2TPNnNCVkeHUh?=
LU-134-A MlHYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4fCPGlEPTB;MD6wOVcyPSEQvF2= NU\yN3RbW0GQR1XS
HCC2157 M2j4TGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGHzOWZKSzVyPUCuNFU4OzNizszN MWTTRW5ITVJ?
GAK M1XtRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1zJeGlEPTB;MD6wOVc{PCEQvF2= NUXkboJpW0GQR1XS
IST-SL2 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHWzRoJKSzVyPUCuNFU4PDNizszN M4TFTXNCVkeHUh?=
KMOE-2 NHnKenlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXvJR|UxRTBwMEW3OFkh|ryP M1nBenNCVkeHUh?=
SW1573 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MonGTWM2OD1yLkC1PFAzKM7:TR?= M1vWeHNCVkeHUh?=
SCC-9 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{fLTGlEPTB;MD6wOVg4KM7:TR?= MoqwV2FPT0WU
MDA-MB-361 NIXPXJNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX;WbYJOUUN3ME2wMlA2QDd{IN88US=> MUPTRW5ITVJ?
BHT-101 MnHLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHvHOXpKSzVyPUCuNFU5PzZizszN NWrO[|VmW0GQR1XS
NCI-H1770 MljDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIK0WWxKSzVyPUCuNFU5PzlizszN NWXNcGJ1W0GQR1XS
UACC-893 NGjVcpRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MU\JR|UxRTBwMEW4PVYh|ryP NXLlRnJjW0GQR1XS
NCI-H226 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX[zPGwxUUN3ME2wMlA2QTh6IN88US=> MY\TRW5ITVJ?
HLE MoC3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{fXZ2lEPTB;MD6wOlA5OiEQvF2= MYLTRW5ITVJ?
NCI-H1703 NFTWVXlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVnsbW9DUUN3ME2wMlA3OTd6IN88US=> NWr4O412W0GQR1XS
KURAMOCHI Mk[2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEnQZmRKSzVyPUCuNFYyQDlizszN NYL5[ZpEW0GQR1XS
RH-1 Mkn0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3fse2lEPTB;MD6wOlI{KM7:TR?= NVvV[mdGW0GQR1XS
DSH1 MkH4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWPtbGpCUUN3ME2wMlA3OjdizszN MYjTRW5ITVJ?
CAMA-1 NGDWWJRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmjwTWM2OD1yLkC2N|A{KM7:TR?= Ml;qV2FPT0WU
NCI-H1437 NF7rWo1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnXKTWM2OD1yLkC2N|I5KM7:TR?= MmHaV2FPT0WU
HuP-T4 NUnYRlh[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVnJR|UxRTBwME[1PFYh|ryP MUPTRW5ITVJ?
HCT-15 NUXZT4pDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NETtVG9KSzVyPUCuNFY2QTdizszN NILMc2tUSU6JRWK=
NCCIT M4L3[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXHJR|UxRTBwME[2NFQh|ryP M{T1XHNCVkeHUh?=
BOKU MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXnJR|UxRTBwME[2O|Qh|ryP MkjNV2FPT0WU
FADU MkjKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M36zOWlEPTB;MD6wOlc1PSEQvF2= Mon6V2FPT0WU
SUP-T1 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV\mfFR[UUN3ME2wMlA3PzZizszN NUTWR29EW0GQR1XS
L-363 M3myVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF7YRnBKSzVyPUCuNFY6ODFizszN NGLicoZUSU6JRWK=
KNS-81-FD MonPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml3ETWM2OD1yLkC2PVE5KM7:TR?= MUPTRW5ITVJ?
SU-DHL-1 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWT5OJEyUUN3ME2wMlA3QTJizszN NVnrVVFrW0GQR1XS
HuH-7 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGTEdJpKSzVyPUCuNFcxOzVizszN NX\odHN2W0GQR1XS
BT-474 M1PzXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHPoOG1KSzVyPUCuNFcxPjFizszN NVLZOmx7W0GQR1XS
CAPAN-1 NW\sNXZvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2LwPWlEPTB;MD6wO|E1OyEQvF2= NYqxWYc{W0GQR1XS
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LU-99A NHrxcHNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn\oTWM2OD1yLkC3Nlg4KM7:TR?= Ml7lV2FPT0WU
WSU-NHL NFm0VYxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVLJR|UxRTBwMEezNlkh|ryP MnKwV2FPT0WU
Calu-1 MlnRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUDJR|UxRTBwMEezN|Ih|ryP NV;ke5g3W0GQR1XS
U-698-M MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVnJR|UxRTBwMEezPFIh|ryP M2TINXNCVkeHUh?=
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GI-ME-N MoLHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUjJR|UxRTBwMEe0NlYh|ryP NIf2W5BUSU6JRWK=
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UACC-257 MormS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFTpOWhKSzVyPUCuNFc2ODVizszN NUXaSWRsW0GQR1XS
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EW-11 MlLtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M17PdmlEPTB;MD6wO|U{PSEQvF2= MWXTRW5ITVJ?
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L-428 MlrYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NW\qS3N5UUN3ME2wMlA4PzB2IN88US=> Ml;UV2FPT0WU
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DMS-153 MlHhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYTuRXFFUUN3ME2wMlA4PzN3IN88US=> MmLvV2FPT0WU
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ESS-1 M{LrN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUm0PJRYUUN3ME2wMlA4QDZ6IN88US=> NGPvTZhUSU6JRWK=
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Calu-6 MmK0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnfQTWM2OD1yLkC3PVY2KM7:TR?= Mnq5V2FPT0WU
COLO-668 NYnVfHZ6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYnFOpFDUUN3ME2wMlA4QTh2IN88US=> NVjEdnJSW0GQR1XS
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NCI-H2347 NVe5ZZU4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWfYSXl5UUN3ME2wMlA5ODJ6IN88US=> Mm\NV2FPT0WU
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NCI-H1304 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWrVPJJEUUN3ME2wMlA5OjdzIN88US=> NX65WnB2W0GQR1XS
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MDA-MB-231 NYXzOnR3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUTxTmgyUUN3ME2wMlA6ODh{IN88US=> NXjQNWNvW0GQR1XS
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MDA-MB-468 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MojzTWM2OD1yLkC5PVg2KM7:TR?= NFrHfJpUSU6JRWK=
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GR-ST NFLDSm5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYHJR|UxRTBwMUCyNUDPxE1? MV7TRW5ITVJ?
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EKVX MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUXJR|UxRTBwMUC0PFMh|ryP M{n3RXNCVkeHUh?=
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EW-18 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkOxTWM2OD1yLkGwOlA1KM7:TR?= M{fPe3NCVkeHUh?=
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NCI-H441 NFPNOoFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUXBT|RKUUN3ME2wMlExQDl7IN88US=> M1rNW3NCVkeHUh?=
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SK-MM-2 NF3RN4VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIHUdFhKSzVyPUCuNVEyPDVizszN MVnTRW5ITVJ?
DEL MkO3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYT1W25{UUN3ME2wMlEyOTl{IN88US=> M1HPZnNCVkeHUh?=
NCI-H661 MoPiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUHnNm5GUUN3ME2wMlEyOTl3IN88US=> M13aZ3NCVkeHUh?=
LC4-1 Ml;yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEXXNYdKSzVyPUCuNVE1PjZizszN MV\TRW5ITVJ?
BEN M1nk[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2fobWlEPTB;MD6xNVYxPyEQvF2= NUnyUpBCW0GQR1XS
RPMI-8226 MnrDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{PsdWlEPTB;MD6xNVcyQSEQvF2= NY\ZV48xW0GQR1XS
AU565 NVm1TIVwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M37wfmlEPTB;MD6xNVg{OSEQvF2= M2rWUHNCVkeHUh?=
CAS-1 MknSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnvpTWM2OD1yLkGxPVY1KM7:TR?= Mk\oV2FPT0WU
UACC-62 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGP6XG9KSzVyPUCuNVIyOiEQvF2= NULONnNbW0GQR1XS
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DMS-53 NH7sUlhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnPNTWM2OD1yLkGyNlc3KM7:TR?= M3vPdHNCVkeHUh?=
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S-117 NYDRPYRFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXnVVZVqUUN3ME2wMlEzPjd2IN88US=> NXXXOpluW0GQR1XS
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NCI-H1755 NFnDcZdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3jXTmlEPTB;MD6xN|gzPyEQvF2= NVSzbm5WW0GQR1XS
D-542MG NVGx[3ZtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1vjPGlEPTB;MD6xN|k3PSEQvF2= M4HLU3NCVkeHUh?=
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OVCAR-3 NUnH[pk{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVnJR|UxRTBwMUSwO|gh|ryP NYG4U3REW0GQR1XS
NCI-H1092 M2\0PWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF32U5BKSzVyPUCuNVQyODFizszN NI\LZWJUSU6JRWK=
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NB1 NFe0c4NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M162Z2lEPTB;MD6xOFQzPiEQvF2= Ml3IV2FPT0WU
HD-MY-Z MmnkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWLEcXBmUUN3ME2wMlE1PDJ7IN88US=> NH7lU5pUSU6JRWK=
SHP-77 NWrvWWE5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3LQ[2lEPTB;MD6xOFQ4OiEQvF2= M2X6eHNCVkeHUh?=
U-266 NH\te5VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWDm[IxuUUN3ME2wMlE1PDhizszN NVXTc3JtW0GQR1XS
GI-1 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUnJR|UxRTBwMUS3O|Ih|ryP MXXTRW5ITVJ?
NCI-H1522 NULocItST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEP3NpNKSzVyPUCuNVQ4QDdizszN M160V3NCVkeHUh?=
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HCT-116 NYrhT3U4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFLFd25KSzVyPUCuNVUyPjlizszN MnrwV2FPT0WU
NCI-H2081 NI\mV5FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4LkXWlEPTB;MD6xOVIyQCEQvF2= M1ztNHNCVkeHUh?=
THP-1 NFjU[Y9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmfLTWM2OD1yLkG1N|M{KM7:TR?= MnTqV2FPT0WU
LU-165 NWrrZZNIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYPJR|UxRTBwMUW0NVMh|ryP NXzRfolTW0GQR1XS
RCM-1 NI[w[pNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmL0TWM2OD1yLkG1Olgh|ryP M1m2fXNCVkeHUh?=
COR-L279 MkfNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIPhSZpKSzVyPUCuNVU5OzZizszN M3HufXNCVkeHUh?=
SK-NEP-1 Mmn2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFuxb5lKSzVyPUCuNVU5QTlizszN MkXMV2FPT0WU
KLE NVTqU5NvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MorKTWM2OD1yLkG2NVY6KM7:TR?= Ml\2V2FPT0WU
NCI-H2170 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGfsbWRKSzVyPUCuNVY{ODRizszN MmPlV2FPT0WU
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CAL-72 Mn3nS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFHIdXJKSzVyPUCuNVY2QSEQvF2= Mnm0V2FPT0WU
K052 NF\3V4lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3zqbWlEPTB;MD6xO|A3OSEQvF2= MXPTRW5ITVJ?
COR-L88 NFH4O5BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYTTPJd5UUN3ME2wMlE4OTF2IN88US=> MVTTRW5ITVJ?
HSC-4 M4rpfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlvZTWM2OD1yLkG3NVYh|ryP NFWzZ5BUSU6JRWK=
GOTO NGTifIpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEfNRoxKSzVyPUCuNVczPDZizszN MlLDV2FPT0WU
MEG-01 NX7BO2h4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHW0[XZKSzVyPUCuNVczPTdizszN MXnTRW5ITVJ?
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NCI-H1581 NH3BT5FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXGwNml3UUN3ME2xMlM2Pjh5IN88US=> M4npN3NCVkeHUh?=
NCI-H748 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH3HOZZKSzVyPUGuN|U4OzhizszN M4DzdnNCVkeHUh?=
HCC1187 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4qxNWlEPTB;MT61OVUzOiEQvF2= NFPYVWlUSU6JRWK=
EoL-1-cell MmPxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml7KTWM2OD1zLkW4PFg6KM7:TR?= NWXpVGZDW0GQR1XS
HuO-3N1 Mmn1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHGyc5JKSzVyPUGuPFM1OTJizszN NVnVPJV1W0GQR1XS
NCI-H1793 NUPhdFF{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUDJR|UxRTFwOEe1PVMh|ryP NF60W4VUSU6JRWK=
Caov-3 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH;iXZJKSzVyPUKuNFA3OjVizszN M1j6ZnNCVkeHUh?=
JAR NG\6O|VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEXU[mJKSzVyPUKuNFc6OiEQvF2= M{DmNHNCVkeHUh?=
SK-MEL-28 Mk\oS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV\wXmhNUUN3ME2yMlE5ODl6IN88US=> Ml7lV2FPT0WU
EM-2 MoPtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoHrTWM2OD1{LkKwNlk{KM7:TR?= M4LQTXNCVkeHUh?=
Mewo Ml7ZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXTheIpTUUN3ME2yMlIzOjZ3IN88US=> M1q0cXNCVkeHUh?=
NCI-H720 NE[xXJFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH3FdIZKSzVyPUKuNlY2QDVizszN NFS5OlRUSU6JRWK=
CAL-54 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkTHTWM2OD1{LkK2O|k2KM7:TR?= NUCxTGhOW0GQR1XS
MC116 NEL0WlNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MW\JR|UxRTJwM{[zPVch|ryP MX7TRW5ITVJ?
DG-75 Mm\tS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkXZTWM2OD1{LkS4OVc3KM7:TR?= M3TnSHNCVkeHUh?=
HCC1143 M4jkVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{XFeWlEPTB;Mj61NFY2QCEQvF2= MlSzV2FPT0WU
FTC-133 NWH5WpU3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWLJR|UxRTJwNUO2PFkh|ryP M13M[HNCVkeHUh?=
AsPC-1 M2rlT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWLHNYNoUUN3ME2yMlU{QTJ7IN88US=> M4e1[XNCVkeHUh?=
NCI-H889 NGnQRXNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWXHdWZmUUN3ME2yMlU3PzB4IN88US=> MlfJV2FPT0WU
HT55 NVXoU2VqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{DXNmlEPTB;Mj62NlAyQSEQvF2= NXqyXnBzW0GQR1XS
UMC-11 MkjiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkLBTWM2OD1{Lke4O|E2KM7:TR?= M3zDbXNCVkeHUh?=
P12-ICHIKAWA NEDLfWNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX\NNHNJUUN3ME2yMlgzODR4IN88US=> MXfTRW5ITVJ?
HCC1395 Ml;MS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX\SSW1{UUN3ME2yMlk5PjB{IN88US=> NFnkPFlUSU6JRWK=
D-283MED NHrmSpRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlfuTWM2OD1|LkG4PVM4KM7:TR?= MWPTRW5ITVJ?
COLO-800 NYXP[phjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXvJR|UxRTNwM{O4PVch|ryP MkHEV2FPT0WU
MFM-223 NUTpWHpZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoXCTWM2OD1|LkO2NFk4KM7:TR?= NGnxZW1USU6JRWK=
TE-5 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIHRWHZKSzVyPUSuOVYyPDdizszN NYr0TGx2W0GQR1XS
NCI-H209 NV7EWpJjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV;JR|UxRTRwN{i1O|Ih|ryP MV;TRW5ITVJ?
SiHa MlHWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWfJR|UxRTRwOUWyNFMh|ryP MW\TRW5ITVJ?
NCI-H1395 Moq2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX;HVmpjUUN3ME21MlExPjN|IN88US=> MYLTRW5ITVJ?
A498 M3n3bmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXfJR|UxRTVwMkGyOVEh|ryP NVTpcXU3W0GQR1XS
ES5 NF;EfmJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXrJR|UxRTVwNkGxO|gh|ryP MkjkV2FPT0WU
MDA-MB-157 M1;EbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV70OIp7UUN3ME21MlY3PDR|IN88US=> NFqzXm1USU6JRWK=
NCI-H1623 NWDqdJUzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NW\CVmZ5UUN3ME21Mlg{PTV4IN88US=> MnXWV2FPT0WU
RPMI-8866 M{HO[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYnJR|UxRTVwOES3PVIh|ryP M4\mPXNCVkeHUh?=
LC-1F NYW2OnZqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH3kfHBKSzVyPU[uNFkzQTFizszN MojwV2FPT0WU
TCCSUP NXi5flFWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHHRT2hKSzVyPU[uOlA{PDlizszN M3TjS3NCVkeHUh?=
TT MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MonRTWM2OD16LkOzNFA6KM7:TR?= MVnTRW5ITVJ?
NCI-H1838 NW\RWZg{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1TaTmlEPTB;OD61NVc{OSEQvF2= NYntVXNlW0GQR1XS
NCI-H322M MlfwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXOwfIM2UUN3ME25MlE3OjhzIN88US=> NYTzbINNW0GQR1XS
NCI-H187 M{\mSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmLWTWM2OD17LkWxPFM2KM7:TR?= NUDOU4g6W0GQR1XS
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SW948 M3\FTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmrITWM2OD1zMD63OVEyKM7:TR?= NWC5UWZjW0GQR1XS
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NCI-H2452 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MljiTWM2OD1zND63N{DPxE1? NWjQVHJYW0GQR1XS
Hs-578-T NUnNRm9LT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2LZS2lEPTB;MUiuOVc2QSEQvF2= M3S4e3NCVkeHUh?=
DV-90 MoHYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWnw[Y5MUUN3ME2xPE46QTR3IN88US=> MUXTRW5ITVJ?
NCI-H1563 NIXLNohIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXfPfmk2UUN3ME2xPU44QDh6IN88US=> NYPINYtiW0GQR1XS
SW780 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmLTTWM2OD1{MT6xN|E5KM7:TR?= NF7S[3hUSU6JRWK=
NCI-H345 NHO4PItIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmTGTWM2OD1{MT64O|c6KM7:TR?= MWnTRW5ITVJ?
LB771-HNC NGPZUoFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlqxTWM2OD1{Mj60PFE{KM7:TR?= Mm\DV2FPT0WU
RT4 NUSxU3BIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4PBZmlEPTB;MkOuN|I5OiEQvF2= M3nG[HNCVkeHUh?=
NCI-H82 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmDLTWM2OD1{Mz61OVI3KM7:TR?= MYTTRW5ITVJ?
NCI-H524 NUGyepNYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWTJR|UxRTJ2LkO4NVIh|ryP MVvTRW5ITVJ?
SNU-C1 NUf1fINGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFz3S4NKSzVyPUK0MlkyODVizszN M{XrXXNCVkeHUh?=
NCI-SNU-16 NUjBOo9NT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWnIflF3UUN3ME20PE4{OTR{IN88US=> NH\vR3RUSU6JRWK=

... Click to View More Cell Line Experimental Data

In vivo Treatment with NVP-AUY922 causes a robust antitumor response and inhibits p-Akt and VEGF expression in an HSC-2 xenograft model. [2] In BT474, NVP-AUY922 shows complete loss of ERBB2 and substantial depletion of ERα, in addition to reductions in CDK4 and phospho-ERK1/2. [3]

Protocol

Kinase Assay:[3]
+ Expand

Kinase assay:

NVP-AUY922 is dissolved in DMSO at a concentration of 10 mM. NVP-AUY922 is assessed against HSP90α, HSP90β, GRP94, TRAP-1, HSP72, and topoisomerase II. Profiling against a panel of kinases has been carried out and screening against a panel of additional enzymes and receptors is performed at Cerep.
Cell Research:[1]
+ Expand
  • Cell lines: Human gastric cancer cells NCI-N87
  • Concentrations: 1 μM
  • Incubation Time: 3 days
  • Method: Human gastric cancer cells NCI-N87 (5-7 ×103 in 50 μL/well) are seeded in 96-well plates and incubated at 37 °C for 24 hours, followed by NVP-AUY922 treatment for 1-3 days at 37 °C. After treatment, the cells are assayed by MTT method and analyzed by microplate reader.
    (Only for Reference)
Animal Research:[3]
+ Expand
  • Animal Models: Female NCr athymic mice bearing WM266.4 human melanoma xenografts
  • Formulation: In DMSO and diluted in sterile saline/Tween 20
  • Dosages: 50 mg/kg
  • Administration: Administered via i.v. or i.p.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 93 mg/mL warmed (199.76 mM)
Ethanol 31 mg/mL (66.58 mM)
Water Insoluble
In vivo Add solvents to the product individually and in order:
1% DMSO+30% polyethylene glycol+1% Tween 80
For best results, use promptly after mixing.
30 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 465.54
Formula

C26H31N3O5

CAS No. 747412-49-3
Storage powder
Synonyms VER-52296

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
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    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
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Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT01784640 Active, not recruiting Recurrent Non-small Cell Lung Cancer|Squamous Cell Lung Cancer|Stage IV Non-small Cell Lung Cancer Jonsson Comprehensive Cancer Center|National Cancer Institute (NCI) January 2014 Phase 1
NCT01922583 Active, not recruiting Non-small Cell Lung Cancer (NSCLC) National Taiwan University Hospital January 2014 Phase 2
NCT01854034 Active, not recruiting Non Small Cell Lung Cancer Massachusetts General Hospital July 2013 Phase 2
NCT01772797 Completed Anaplastic Lymphoma Kinase (ALK)|Non-small Cell Lung Cancer Novartis Pharmaceuticals|Novartis June 2013 Phase 1
NCT01752400 Active, not recruiting Non Small Cell Lung Cancer Massachusetts General Hospital January 2013 Phase 2
NCT01613950 Completed Stomach Neoplasms Esophageal Neoplasms Metastatic Gastric Cancer Mutated PI3KCA Protein Overexpressed HER2 Protein Novartis Pharmaceuticals|Novartis December 2012 Phase 1

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID