Luminespib (AUY-922, NVP-AUY922)

Catalog No.S1069 Synonyms: VER-52296

Luminespib (AUY-922, NVP-AUY922) Chemical Structure

Molecular Weight(MW): 465.54

Luminespib (AUY-922, NVP-AUY922) is a highly potent HSP90 inhibitor for HSP90α/β with IC50 of 13 nM /21 nM in cell-free assays, weaker potency against the HSP90 family members GRP94 and TRAP-1, exhibits the tightest binding of any small-molecule HSP90 ligand. Phase 2.

Size Price Stock Quantity  
In DMSO USD 320 In stock
USD 160 In stock
USD 270 In stock
USD 470 In stock

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3 Customer Reviews

  • U2OS_exo cells were incubated with AUY922 for 20 h at the indicated concentrations before stimulation with TNFα (30 ng/mL) for 30 min and immunostaining to detect NF-κB (p65). DMSO 1%, cells stimulated by TNFα in the absence of AUY922. Representative pictures used to quantify nuclear and cytoplasmic localization of NF-κB.

    Proc Natl Acad Sci USA, 2014, 111(15): E1528–37 . Luminespib (AUY-922, NVP-AUY922) purchased from Selleck.

    J Biol Chem 2013 288(23), 16308-20. Luminespib (AUY-922, NVP-AUY922) purchased from Selleck.

  • Western blots show the molecular signature of HSP90 inhibition by NVP-AUY922  (ie, induction of HSP72 and depletion of client proteins such as ERBB2, CRAF and CDK4) in BT474 breast cancer cell line. GAPDH was used as loading control.

     

     

    2011 Dr. Swee Sharp and Professor Paul Workman from Cancer Research UK. Luminespib (AUY-922, NVP-AUY922) purchased from Selleck.

Purity & Quality Control

Choose Selective HSP (e.g. HSP90) Inhibitors

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Notes:

2. For more details, such as half maximal inhibitory concentrations (IC50s) and working concentrations of each inhibitor, please click on the link of the inhibitor of interest.
3. "+" indicates inhibitory effect. Increased inhibition is marked by a higher "+" designation.
4. Orange "√" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

Biological Activity

Description Luminespib (AUY-922, NVP-AUY922) is a highly potent HSP90 inhibitor for HSP90α/β with IC50 of 13 nM /21 nM in cell-free assays, weaker potency against the HSP90 family members GRP94 and TRAP-1, exhibits the tightest binding of any small-molecule HSP90 ligand. Phase 2.
Targets
HSP90α [1]
(Cell-free assay)
HSP90β [1]
(Cell-free assay)
13 nM 21 nM
In vitro

NVP-AUY922 inhibits proliferation of various human cancer cell lines in vitro, with an average GI50 of 9 nM. [1] The IC50 values of NVP-AUY922 fall in the range of 2 to 40 nM in these gastric cancer cell lines. IC50 value for the BEAS-2B cells is 28.49 nM. Treatment with NVP-AUY922 does not influence the expression of HSP90, but expression of HSP70 gets elevated by NVP-AUY922 treatment. NVP-AUY922 increases the binding of HSP70 to HSP90. NVP-AUY922 causes p23 dissociation from the HSP90 complex and can then recruit HSP70 to the HSP90 complex. [1] After the treatment with NVP-AUY922, expression of receptor tyrosine kinases including VEGFR1, 2, 3 and PDGFRɑ is decreased. A decrease is also noticed in the expression of Akt and phospho-Akt. Meanwhile, treatment with NVP-AUY922 causes decreased expression of HER-2 in NCI-N87 cells. NVP-AUY922 treatment results in binding of HSP90 to client proteins and setting them up as targets for degradation by the proteasome. NVP-AUY922 can influence cell growth by affecting multiple signaling pathways. In addition, treatment with the proteasome inhibitor, MG132, restores expression of thymidylate synthase, which is decreased by NVP-AUY922. NVP-AUY922 increases the expression of cleaved caspase-3 leading to apoptosis in HSC-2 cells.[1]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
CMK NYW3flBNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXvOeHg5UUN3ME2wMlAxODF{NTFOwG0> M2jLTHNCVkeHUh?=
MV-4-11 NWKzRploT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MULJR|UxRTBwMECwOVU5KM7:TR?= MVHTRW5ITVJ?
NALM-6 NV\5eW1UT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHn5UWtKSzVyPUCuNFAxQDR{IN88US=> Mne3V2FPT0WU
HOS MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MknITWM2OD1yLkCwNVM5KM7:TR?= MlzwV2FPT0WU
HT-144 NUH5TWM1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGX2cJlKSzVyPUCuNFAyPTVizszN MWnTRW5ITVJ?
SW1710 NETZTJNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3vpVmlEPTB;MD6wNFE5PiEQvF2= MmP6V2FPT0WU
TE-8 M1L0dmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFXZc2FKSzVyPUCuNFAzOzdizszN M1XIUHNCVkeHUh?=
ES1 M4n6Tmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUXGSnRuUUN3ME2wMlAxOjZ4IN88US=> MofRV2FPT0WU
CCF-STTG1 M4j6UGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mk\yTWM2OD1yLkCwNlk4KM7:TR?= MkHEV2FPT0WU
PSN1 M3\SO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmDBTWM2OD1yLkCwN|E5KM7:TR?= NX7DPJRPW0GQR1XS
CAL-51 Mo\6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoXaTWM2OD1yLkCwN|I2KM7:TR?= NEfWPJNUSU6JRWK=
MCF7 M{TkT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{DrbmlEPTB;MD6wNFM{PSEQvF2= NHLudnJUSU6JRWK=
SK-HEP-1 Ml7zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXrQd5k{UUN3ME2wMlAxOzN4IN88US=> MmfpV2FPT0WU
LCLC-103H M3XaT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXG2PGhlUUN3ME2wMlAxPDNizszN M{e1TXNCVkeHUh?=
HMV-II M1zmd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF;Sb|VKSzVyPUCuNFA1PDlizszN MXzTRW5ITVJ?
MES-SA NXHxW5RmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXTJR|UxRTBwMEC0OVIh|ryP MkDNV2FPT0WU
SK-LMS-1 NIHGTohIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVj3[JJZUUN3ME2wMlAxPDV6IN88US=> MnjQV2FPT0WU
639-V NHPy[|hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXi3N5BGUUN3ME2wMlAxPDh3IN88US=> MkfZV2FPT0WU
SIG-M5 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlPDTWM2OD1yLkCwOFg6KM7:TR?= MkDkV2FPT0WU
LOUCY M4TU[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mlr6TWM2OD1yLkCwOVA2KM7:TR?= MYLTRW5ITVJ?
HSC-2 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHzueJFKSzVyPUCuNFA2OThizszN NUjRfFlVW0GQR1XS
EW-13 M{fRSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH3hS5pKSzVyPUCuNFA2OThizszN MoHZV2FPT0WU
RT-112 MlPuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWi0XIxXUUN3ME2wMlAxPTN3IN88US=> NIP0VYxUSU6JRWK=
NKM-1 Ml22S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn7aTWM2OD1yLkCwOVQ4KM7:TR?= MnO3V2FPT0WU
KYSE-180 M{TGSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUjkb4UzUUN3ME2wMlAxPTh4IN88US=> M{\jZ3NCVkeHUh?=
SW1783 NHKzZmtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHnoSIJKSzVyPUCuNFA2QTFizszN MlvZV2FPT0WU
A431 NGnse2VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUfqdmhEUUN3ME2wMlAxPjB5IN88US=> NXL1NWR[W0GQR1XS
SK-OV-3 M2Tlbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWTjWVR2UUN3ME2wMlAxPjNizszN MlTIV2FPT0WU
RPMI-7951 NXnqZ4pDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkfGTWM2OD1yLkCwOlMyKM7:TR?= NWK1U416W0GQR1XS
Capan-2 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVW4fVFlUUN3ME2wMlAxPjN6IN88US=> Mnf0V2FPT0WU
HSC-3 MlL3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3GyNWlEPTB;MD6wNFY1OSEQvF2= M{SyOHNCVkeHUh?=
786-0 NXOxZpZ6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn3HTWM2OD1yLkCwOlY{KM7:TR?= NEPMV|FUSU6JRWK=
Daoy M3PBV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWXsUmtZUUN3ME2wMlAxPjl3IN88US=> M4DjenNCVkeHUh?=
KGN NGX3WVdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkDaTWM2OD1yLkCwO|A{KM7:TR?= Mo[2V2FPT0WU
EW-16 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUftSIoxUUN3ME2wMlAxPzR7IN88US=> M332dnNCVkeHUh?=
EW-7 NWOyT2xST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWnJR|UxRTBwMEC3OVQh|ryP NEnyXXNUSU6JRWK=
IGROV-1 M{HITGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYjJR|UxRTBwMEC4NVQh|ryP NInKRYlUSU6JRWK=
8505C MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGTS[GZKSzVyPUCuNFA5OjFizszN M3LTR3NCVkeHUh?=
RKO MlPtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXLWbIs2UUN3ME2wMlAxQDJ4IN88US=> M3nNeXNCVkeHUh?=
GDM-1 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml;zTWM2OD1yLkCwPFQh|ryP NUD6fY1uW0GQR1XS
IST-MEL1 NFvpUXhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFL3[4lKSzVyPUCuNFA5PTJizszN NV;ieGNiW0GQR1XS
RPMI-6666 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFf5OGNKSzVyPUCuNFA5PTJizszN MV3TRW5ITVJ?
SNG-M Mo\BS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1z3fWlEPTB;MD6wNFg2PiEQvF2= M122Z3NCVkeHUh?=
KS-1 NUK4RopNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEXuWodKSzVyPUCuNFA5PTlizszN NWHVUFJiW0GQR1XS
RXF393 NIrUR2NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkPnTWM2OD1yLkCwPFYh|ryP NFjm[3hUSU6JRWK=
CAL-12T MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{nGNGlEPTB;MD6wNFkzOiEQvF2= M{npcnNCVkeHUh?=
BFTC-905 MmfaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYK0fpF[UUN3ME2wMlAxQTN6IN88US=> NX\TbmtQW0GQR1XS
SK-MES-1 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2fp[2lEPTB;MD6wNFk1PSEQvF2= M3u3VnNCVkeHUh?=
BB30-HNC M1XiO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVnpR2pJUUN3ME2wMlAxQTV{IN88US=> MmXlV2FPT0WU
AN3-CA M125U2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mm\oTWM2OD1yLkCxNFE4KM7:TR?= MYPTRW5ITVJ?
EFO-27 M3rmbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4W1UGlEPTB;MD6wNVAyPyEQvF2= MkjhV2FPT0WU
G-401 M1HnfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF;2PFhKSzVyPUCuNFExOjVizszN M{fpR3NCVkeHUh?=
BPH-1 NHT2TFZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYrJR|UxRTBwMEGwN{DPxE1? NVrsV41lW0GQR1XS
NCI-H727 M2PaOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFi0T3pKSzVyPUCuNFExOyEQvF2= NYe0UGQxW0GQR1XS
SNU-423 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEnvfXFKSzVyPUCuNFExPTNizszN MXfTRW5ITVJ?
KYSE-270 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1HmT2lEPTB;MD6wNVA2QSEQvF2= MmH2V2FPT0WU
AGS MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1Pl[2lEPTB;MD6wNVA3OSEQvF2= MW\TRW5ITVJ?
NCI-H2228 MkjqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mk\NTWM2OD1yLkCxNFY1KM7:TR?= M1fyOnNCVkeHUh?=
SW954 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXfJR|UxRTBwMEGwO|Eh|ryP MofuV2FPT0WU
769-P NVfsTItUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mk\yTWM2OD1yLkCxNFc{KM7:TR?= NYrWRmF{W0GQR1XS
BB49-HNC NITMe3lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NU\nO5ZLUUN3ME2wMlAyODd5IN88US=> NVHM[3ZHW0GQR1XS
IA-LM M3PFNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2fZOWlEPTB;MD6wNVA5PiEQvF2= M1fLOXNCVkeHUh?=
NB69 NGLLOXRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV7Yb4ZQUUN3ME2wMlAyOTB{IN88US=> MVTTRW5ITVJ?
C8166 NIXlNWJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV3He3l4UUN3ME2wMlAyOTJ7IN88US=> MUPTRW5ITVJ?
NCI-H1299 M3G1eWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{HNeWlEPTB;MD6wNVE2PCEQvF2= NVXHe3lnW0GQR1XS
YKG-1 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVrPR|lCUUN3ME2wMlAyOTZizszN MmrZV2FPT0WU
PANC-03-27 MlPUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUS1blBQUUN3ME2wMlAyOTZ{IN88US=> NXPJN4FEW0GQR1XS
YT MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4fJSGlEPTB;MD6wNVE4QSEQvF2= NGX2VoZUSU6JRWK=
CAL-85-1 M{TIWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWHwd4VnUUN3ME2wMlAyOTl{IN88US=> NFTXdpBUSU6JRWK=
GT3TKB MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYCySHhjUUN3ME2wMlAyOjB{IN88US=> MW\TRW5ITVJ?
BB65-RCC Mn[3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M13XWGlEPTB;MD6wNVIxPCEQvF2= M3fD[HNCVkeHUh?=
ES6 NWPmTlFTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmD4TWM2OD1yLkCxNlYyKM7:TR?= NYLqUJNLW0GQR1XS
MHH-ES-1 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4n0RmlEPTB;MD6wNVI3OyEQvF2= NUm0S2lbW0GQR1XS
QIMR-WIL NXjMXYFpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYfJR|UxRTBwMEGyOlkh|ryP NGjlU2xUSU6JRWK=
SNU-C2B M3uydmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV\yPFhyUUN3ME2wMlAyOjd{IN88US=> MkTCV2FPT0WU
OCI-AML2 MnzJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGX2SmlKSzVyPUCuNFEzQDFizszN M4HGTHNCVkeHUh?=
DU-145 M3HRe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHvaOXRKSzVyPUCuNFEzQSEQvF2= MWHTRW5ITVJ?
SW982 MmXKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4nHOmlEPTB;MD6wNVI6OyEQvF2= MnTxV2FPT0WU
MFH-ino MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV61XpdkUUN3ME2wMlAyOjl|IN88US=> Ml;XV2FPT0WU
A427 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn;4TWM2OD1yLkCxNlk6KM7:TR?= MVHTRW5ITVJ?
LCLC-97TM1 Mmn4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYPJR|UxRTBwMEGzJO69VQ>? NV7iOJllW0GQR1XS
AM-38 Mn3GS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnX5TWM2OD1yLkCxN|AzKM7:TR?= MnK3V2FPT0WU
K5 MoTXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVnJR|UxRTBwMEGzNFgh|ryP MUjTRW5ITVJ?
T84 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVHJR|UxRTBwMEGzN|Eh|ryP M1v5RnNCVkeHUh?=
TE-15 NInte2ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVjJR|UxRTBwMEGzN|Yh|ryP NFzVPYhUSU6JRWK=
NCI-H460 NXO2T5U{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnPPTWM2OD1yLkCxN|M3KM7:TR?= NYnaUW9iW0GQR1XS
NTERA-S-cl-D1 M2GzbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlW4TWM2OD1yLkCxN|M6KM7:TR?= MlvsV2FPT0WU
KYSE-450 NF7EeGJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGj4d5NKSzVyPUCuNFE{PDlizszN NUjlZ40yW0GQR1XS
H4 MljBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXjLfHc4UUN3ME2wMlAyOzZ4IN88US=> M1ewNnNCVkeHUh?=
LC-2-ad M{Loe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4fwUGlEPTB;MD6wNVM4KM7:TR?= MkOyV2FPT0WU
GAMG NX\1TGVCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2iweGlEPTB;MD6wNVM4OSEQvF2= NYn6OHFsW0GQR1XS
TK10 MomxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmnlTWM2OD1yLkCxN|gzKM7:TR?= NW\6[YU2W0GQR1XS
NCI-H2122 M4DJXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4HLZ2lEPTB;MD6wNVM5PCEQvF2= MWjTRW5ITVJ?
KM12 NYDFV2tPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWPJR|UxRTBwMEGzPVkh|ryP MkOyV2FPT0WU
CAL-39 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWTJR|UxRTBwMEG0NkDPxE1? NXWydohsW0GQR1XS
RPMI-2650 M{\YNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEPmTVNKSzVyPUCuNFE1OzJizszN M2DjSnNCVkeHUh?=
KYSE-510 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3:1[mlEPTB;MD6wNVQ1OiEQvF2= MXrTRW5ITVJ?
KALS-1 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWXneYRGUUN3ME2wMlAyPDZ4IN88US=> M{fJW3NCVkeHUh?=
NCI-H1648 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXfCRnhWUUN3ME2wMlAyPDl7IN88US=> M3G2enNCVkeHUh?=
ES4 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXLJR|UxRTBwMEG1NFIh|ryP NF3DdJpUSU6JRWK=
C-33-A MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NG[4V|RKSzVyPUCuNFE2ODlizszN M{XNe3NCVkeHUh?=
MIA-PaCa-2 MoPLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVXJR|UxRTBwMEG1NFkh|ryP MkjpV2FPT0WU
Becker NWTIZYFNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3TZc2lEPTB;MD6wNVUyPCEQvF2= M3nKWnNCVkeHUh?=
HOP-62 NYDyVY5FT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGKwfpJKSzVyPUCuNFE2PDJizszN MkfEV2FPT0WU
TE-1 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmDITWM2OD1yLkCxOVgyKM7:TR?= NWDvT25XW0GQR1XS
KYSE-410 NYDUepMxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGL1eFBKSzVyPUCuNFE2QDZizszN M{X3cnNCVkeHUh?=
NOS-1 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4Hk[mlEPTB;MD6wNVU6OyEQvF2= MUnTRW5ITVJ?
MEL-HO NHzjW5lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWfJR|UxRTBwMEG2OFMh|ryP M1HES3NCVkeHUh?=
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Daudi NYPaeGZuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4TmeWlEPTB;MD6wN|M4PiEQvF2= MVzTRW5ITVJ?
RS4-11 M32y[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkXyTWM2OD1yLkCzN|g{KM7:TR?= MUHTRW5ITVJ?
JiyoyeP-2003 NGXpboFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{C0UWlEPTB;MD6wN|M5QCEQvF2= M2joPHNCVkeHUh?=
BL-70 NXHDO4lIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXrZNJZ1UUN3ME2wMlA{Ozh7IN88US=> MmXIV2FPT0WU
OS-RC-2 NEfMZodIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEXzbIxKSzVyPUCuNFM{QTZizszN NVLNO5hsW0GQR1XS
SF268 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NI\nPVFKSzVyPUCuNFM1ODFizszN MVHTRW5ITVJ?
BV-173 MkTpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIf0[GZKSzVyPUCuNFM1OjZizszN NG\3RXJUSU6JRWK=
DMS-273 NXjVRZhjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVHJR|UxRTBwMEO0O|kh|ryP NUe2NVlTW0GQR1XS
22RV1 M3\uTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mnq0TWM2OD1yLkCzOVA4KM7:TR?= Mn\CV2FPT0WU
ES8 M4TIdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1PHNmlEPTB;MD6wN|U{QCEQvF2= MnrVV2FPT0WU
KYSE-150 Ml;DS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mly1TWM2OD1yLkCzOlA5KM7:TR?= NUi4NGxKW0GQR1XS
HCC1569 NVyxT3FIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{nhZ2lEPTB;MD6wN|YxQCEQvF2= NUfqe4pEW0GQR1XS
NB5 NUTKNFlKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXjUcYxFUUN3ME2wMlA{PjF|IN88US=> NEDmXZVUSU6JRWK=
G-402 NHnTeHFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFTTRolKSzVyPUCuNFM3OTRizszN NHj1WnlUSU6JRWK=
NCI-H1693 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUnFU2oxUUN3ME2wMlA{PjF5IN88US=> MULTRW5ITVJ?
LB2241-RCC M2rEUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2jEbGlEPTB;MD6wN|Y1OiEQvF2= M17HbnNCVkeHUh?=
KP-4 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGPrVZdKSzVyPUCuNFM3PjNizszN NXvhcYIzW0GQR1XS
ML-2 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoDvTWM2OD1yLkCzOlcyKM7:TR?= NHu1bFVUSU6JRWK=
KU812 NULud3NNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVPpXnJSUUN3ME2wMlA{Pjh2IN88US=> Ml\jV2FPT0WU
LS-411N NVXBOoFXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYXJR|UxRTBwMEO3N|Eh|ryP MWLTRW5ITVJ?
OAW-42 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlSxTWM2OD1yLkCzO|Q4KM7:TR?= NYXv[GtKW0GQR1XS
HCC38 NGjhbpZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEfvOYdKSzVyPUCuNFM4PzFizszN MoXsV2FPT0WU
Ca-Ski M3u1XGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MknxTWM2OD1yLkCzO|g1KM7:TR?= NYWxNnNUW0GQR1XS
Calu-3 M3rGW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnOwTWM2OD1yLkCzO|g6KM7:TR?= NWr0T|I2W0GQR1XS
KYSE-70 NUXZUVF3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUj0SodZUUN3ME2wMlA{QDF{IN88US=> NWL4fYtxW0GQR1XS
D-392MG MkDWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX7JR|UxRTBwMEO4OFIh|ryP M{LIcHNCVkeHUh?=
OVCAR-4 M3;hTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2\ESGlEPTB;MD6wN|g2QCEQvF2= MYXTRW5ITVJ?
Detroit562 NXTuNlF2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEfybJZKSzVyPUCuNFM5PzJizszN MofvV2FPT0WU
HEL NYPhS4RFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3f2fGlEPTB;MD6wN|g6OSEQvF2= MUDTRW5ITVJ?
MONO-MAC-6 MlWzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoDSTWM2OD1yLkCzPFk{KM7:TR?= MWDTRW5ITVJ?
LoVo NX3SOog4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVjtOodrUUN3ME2wMlA{QTN|IN88US=> NUL5OYQzW0GQR1XS
U-2-OS MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVvPZ|luUUN3ME2wMlA{QTN3IN88US=> M37JZnNCVkeHUh?=
A172 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH3DVFZKSzVyPUCuNFM6PSEQvF2= M3juZ3NCVkeHUh?=
OCUB-M M4PyVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1X1ZWlEPTB;MD6wN|k3OSEQvF2= M3flO3NCVkeHUh?=
SW48 NEX3UHBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXrqWppOUUN3ME2wMlA1ODNzIN88US=> M{P6UHNCVkeHUh?=
HC-1 NV\zOWVET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUXtRnI5UUN3ME2wMlA1ODZ7IN88US=> NXTUd2o3W0GQR1XS
KOSC-2 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGj3PWJKSzVyPUCuNFQyOSEQvF2= NIX3N2pUSU6JRWK=
HDLM-2 M3XVfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3XCUGlEPTB;MD6wOFEyPCEQvF2= MUTTRW5ITVJ?
CTV-1 NVqyc3hiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmrCTWM2OD1yLkC0NVE3KM7:TR?= MXjTRW5ITVJ?
SH-4 NYSzSmUzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVrJR|UxRTBwMESxOFEh|ryP MmLPV2FPT0WU
SW756 NGDxZoVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4P0cWlEPTB;MD6wOFE2PyEQvF2= NXPJc3V{W0GQR1XS
GCT NGDzRZBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV3JR|UxRTBwMESxOlEh|ryP NHjTcIJUSU6JRWK=
CHL-1 NUKyUY5pT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4TDd2lEPTB;MD6wOFE3QSEQvF2= M3zydnNCVkeHUh?=
LAMA-84 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYnJR|UxRTBwMESxO|Eh|ryP M{PCdXNCVkeHUh?=
LS-1034 MorhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVOwbmwyUUN3ME2wMlA1OTlzIN88US=> NEG4bIdUSU6JRWK=
NCI-H358 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHvwUYpKSzVyPUCuNFQzOTJizszN MmXVV2FPT0WU
NB13 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWHiPGo{UUN3ME2wMlA1OjJ5IN88US=> MlPMV2FPT0WU
TE-9 M{DuNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXziV|hPUUN3ME2wMlA1OjN5IN88US=> MUPTRW5ITVJ?
OE33 NUjJT|FzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYLJR|UxRTBwMESyOFEh|ryP NVjQO4luW0GQR1XS
CAL-120 NYfhR3ZkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWXJR|UxRTBwMESyOFEh|ryP M2ryd3NCVkeHUh?=
DJM-1 M4[4WGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFrrNYtKSzVyPUCuNFQzPzJizszN M3rhPXNCVkeHUh?=
SK-MEL-24 MlKxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEHOb5NKSzVyPUCuNFQzQDNizszN MVTTRW5ITVJ?
VA-ES-BJ MkTFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVTJR|UxRTBwMESyPVIh|ryP M164S3NCVkeHUh?=
MMAC-SF NGTUNo1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3;GNmlEPTB;MD6wOFI6PyEQvF2= NHHRcndUSU6JRWK=
MZ7-mel Mk\XS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWnScIR4UUN3ME2wMlA1OzNizszN NEf0cWxUSU6JRWK=
BxPC-3 NWPPbIV2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVLUNG9HUUN3ME2wMlA1OzRzIN88US=> M33IOXNCVkeHUh?=
HT-29 NXjoOZB5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NETkeGVKSzVyPUCuNFQ{PTdizszN NVG5NY1uW0GQR1XS
SK-MEL-30 NWrOeJg1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHnyNIhKSzVyPUCuNFQ{PjJizszN M{jwe3NCVkeHUh?=
CAL-33 NEXL[JNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{jXT2lEPTB;MD6wOFM4PSEQvF2= Mmq2V2FPT0WU
COLO-680N M2rvVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFXQUVlKSzVyPUCuNFQ1ODdizszN M1jZUXNCVkeHUh?=
NH-12 M1LI[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUXJR|UxRTBwMES0OEDPxE1? NW\6OGZsW0GQR1XS
HCC1937 MmG3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnPOTWM2OD1yLkC0OFU3KM7:TR?= NEPiNWlUSU6JRWK=
IMR-5 NHHxOVlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF76VItKSzVyPUCuNFQ1QSEQvF2= MW\TRW5ITVJ?
MC-CAR MkXhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{f5XmlEPTB;MD6wOFU3QSEQvF2= M1HZZnNCVkeHUh?=
NCI-H747 MkTFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXPJR|UxRTBwMES1O{DPxE1? MYXTRW5ITVJ?
NCI-H1792 NITzPVhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXX6TlhwUUN3ME2wMlA1PThzIN88US=> MmTIV2FPT0WU
SW13 M1jOSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUjJR|UxRTBwMES1PUDPxE1? M2j4WnNCVkeHUh?=
MLMA NEPF[|lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlHVTWM2OD1yLkC0OlA6KM7:TR?= M4nrfXNCVkeHUh?=
U251 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlG3TWM2OD1yLkC0O|Y{KM7:TR?= MXPTRW5ITVJ?
U031 NFnwdopIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX;JR|UxRTBwMES3O|Eh|ryP MXLTRW5ITVJ?
ME-180 NHHiVGNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF7JcIZKSzVyPUCuNFQ4QDJizszN MUnTRW5ITVJ?
SK-MEL-3 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXTJR|UxRTBwMES4NFIh|ryP NXu0UpBiW0GQR1XS
MOLT-4 NHzHV3BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MULJR|UxRTBwMES4NFMh|ryP NHLNXmdUSU6JRWK=
PF-382 MlTaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV\JR|UxRTBwMES4NlYh|ryP MkHlV2FPT0WU
NUGC-3 M2PJXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWPJR|UxRTBwMES4Nlch|ryP MVzTRW5ITVJ?
NCI-H1417 NVS5VnFzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3PMU2lEPTB;MD6wOFg6KM7:TR?= MVTTRW5ITVJ?
COLO-205 NILucVRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2e5O2lEPTB;MD6wOFkyQSEQvF2= NX3KVGRwW0GQR1XS
TE-441-T Ml76S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGTPVINKSzVyPUCuNFQ6OyEQvF2= MUfTRW5ITVJ?
MKN1 NUHpdVV[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUm1THpJUUN3ME2wMlA1QTNizszN M1zOXnNCVkeHUh?=
UM-UC-3 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWrvOlhVUUN3ME2wMlA1QTVizszN MkHsV2FPT0WU
SF126 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGf1fZRKSzVyPUCuNFUxOSEQvF2= MYfTRW5ITVJ?
LB1047-RCC MojuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXXrVZBUUUN3ME2wMlA2ODNzIN88US=> MlfSV2FPT0WU
A253 M{TY[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1LVUmlEPTB;MD6wOVA2OiEQvF2= NHn6U4lUSU6JRWK=
NCI-H1963 NVfabFM1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{O2S2lEPTB;MD6wOVE4PiEQvF2= MoTHV2FPT0WU
VM-CUB-1 NFXDcm9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3Hw[2lEPTB;MD6wOVMyOSEQvF2= NYLRepB[W0GQR1XS
T-24 NY\T[lczT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXiwOoEyUUN3ME2wMlA2Ozh2IN88US=> MX;TRW5ITVJ?
K-562 MnP2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYn0NlA3UUN3ME2wMlA2Ozh5IN88US=> MnrsV2FPT0WU
ARH-77 NGG2cnZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mle1TWM2OD1yLkC1N|k2KM7:TR?= NWXmU2h[W0GQR1XS
CA46 MkLUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVThT2E5UUN3ME2wMlA2PDNizszN M4LPVnNCVkeHUh?=
HCC70 NGHxPFlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH2zSHVKSzVyPUCuNFU1PTJizszN MkXYV2FPT0WU
ST486 M37wXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M122SmlEPTB;MD6wOVUzPSEQvF2= MYfTRW5ITVJ?
COLO-741 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2H3VmlEPTB;MD6wOVU{OSEQvF2= NV\HXGNNW0GQR1XS
SK-PN-DW M3\zfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmSwTWM2OD1yLkC1OVg5KM7:TR?= M4Kz[HNCVkeHUh?=
BL-41 NH:wb4JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVv5XldyUUN3ME2wMlA2PTl4IN88US=> NILBUXRUSU6JRWK=
D-263MG M1fIW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGDMVldKSzVyPUCuNFU3QDNizszN MlXXV2FPT0WU
KE-37 NFPXXXBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV\MWXlEUUN3ME2wMlA2Pjh|IN88US=> NVn3PWpTW0GQR1XS
LU-134-A MnTzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUjJR|UxRTBwMEW3NVUh|ryP M{DzeXNCVkeHUh?=
HCC2157 Ml3VS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1nwc2lEPTB;MD6wOVc{OyEQvF2= Ml7LV2FPT0WU
GAK NHzl[3RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHP4OXRKSzVyPUCuNFU4OzRizszN NHnVU|hUSU6JRWK=
IST-SL2 NHXiXoVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHLmRZNKSzVyPUCuNFU4PDNizszN NIPUVGpUSU6JRWK=
KMOE-2 MoTiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1\tOGlEPTB;MD6wOVc1QSEQvF2= MV;TRW5ITVJ?
SW1573 M2LIVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHT3TlJKSzVyPUCuNFU5ODJizszN M3;xV3NCVkeHUh?=
SCC-9 M1HMb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmH1TWM2OD1yLkC1PFch|ryP NHG3VJdUSU6JRWK=
MDA-MB-361 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVvhNJhCUUN3ME2wMlA2QDd{IN88US=> MnHtV2FPT0WU
BHT-101 M2jTVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWPLNWU4UUN3ME2wMlA2QDd4IN88US=> NF65NZdUSU6JRWK=
NCI-H1770 M1y5OWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVrJR|UxRTBwMEW4O|kh|ryP NW\0NmI2W0GQR1XS
UACC-893 M{LDOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MljZTWM2OD1yLkC1PFk3KM7:TR?= M1rXUXNCVkeHUh?=
NCI-H226 NHOwVVRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXf1SFJbUUN3ME2wMlA2QTh6IN88US=> MlHYV2FPT0WU
HLE MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mo\LTWM2OD1yLkC2NFgzKM7:TR?= M2XjWnNCVkeHUh?=
NCI-H1703 M2e1U2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWPJR|UxRTBwME[xO|gh|ryP MVLTRW5ITVJ?
KURAMOCHI NH;jcGhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVrkTlVVUUN3ME2wMlA3OTh7IN88US=> NFP5O29USU6JRWK=
RH-1 NHPoZ3JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3nD[GlEPTB;MD6wOlI{KM7:TR?= M4f3WnNCVkeHUh?=
DSH1 NFmxb21Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUDJR|UxRTBwME[yO{DPxE1? M2PnVHNCVkeHUh?=
CAMA-1 MmXYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NY\TZ2hFUUN3ME2wMlA3OzB|IN88US=> NWDjeGV2W0GQR1XS
NCI-H1437 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoPyTWM2OD1yLkC2N|I5KM7:TR?= MmS1V2FPT0WU
HuP-T4 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYCxeolQUUN3ME2wMlA3PTh4IN88US=> NVrJXI4yW0GQR1XS
HCT-15 M3O0TGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWnJR|UxRTBwME[1PVch|ryP NUDZXFZNW0GQR1XS
NCCIT NXjBRZp3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2ewSWlEPTB;MD6wOlYxPCEQvF2= NEnRUodUSU6JRWK=
BOKU MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVfJR|UxRTBwME[2O|Qh|ryP NEjaW2RUSU6JRWK=
FADU NXX4e3JuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYnJR|UxRTBwME[3OFUh|ryP M3TSe3NCVkeHUh?=
SUP-T1 M1yxRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2jOVWlEPTB;MD6wOlc3KM7:TR?= NVfXcnR5W0GQR1XS
L-363 M1GzZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYCwSGFKUUN3ME2wMlA3QTBzIN88US=> MlL0V2FPT0WU
KNS-81-FD NFP3fJdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1;vXmlEPTB;MD6wOlkyQCEQvF2= M3Ltb3NCVkeHUh?=
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RO82-W-1 NU\zVWF{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWfJR|UxRTFwM{OzN|kh|ryP NV\a[ld2W0GQR1XS
NCI-H1581 NW[1[ZpZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVrNTFliUUN3ME2xMlM2Pjh5IN88US=> NWS3b4t[W0GQR1XS
NCI-H748 Mn3ES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlTrTWM2OD1zLkO1O|M5KM7:TR?= M4HTPXNCVkeHUh?=
HCC1187 MnfaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFe4NW9KSzVyPUGuOVU2OjJizszN MWnTRW5ITVJ?
EoL-1-cell NWXEVYRpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2TjXWlEPTB;MT61PFg5QSEQvF2= NFv2XnBUSU6JRWK=
HuO-3N1 M{DTXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWfJR|UxRTFwOEO0NVIh|ryP NV\XdGY2W0GQR1XS
NCI-H1793 Ml7zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX3uW3M6UUN3ME2xMlg4PTl|IN88US=> MmTrV2FPT0WU
Caov-3 MoezS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlfsTWM2OD1{LkCwOlI2KM7:TR?= NGHHWpBUSU6JRWK=
JAR M3P2OWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1;peGlEPTB;Mj6wO|kzKM7:TR?= NIPxSlhUSU6JRWK=
SK-MEL-28 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWjJR|UxRTJwMUiwPVgh|ryP NETwUo1USU6JRWK=
EM-2 MlzGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnG5TWM2OD1{LkKwNlk{KM7:TR?= MVrTRW5ITVJ?
Mewo Mo\yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4DkVWlEPTB;Mj6yNlI3PSEQvF2= NF7y[JpUSU6JRWK=
NCI-H720 NV;mRXB1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Moe5TWM2OD1{LkK2OVg2KM7:TR?= M{\wfnNCVkeHUh?=
CAL-54 NHP5[|hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3XQVmlEPTB;Mj6yOlc6PSEQvF2= MmfZV2FPT0WU
MC116 NG\qSIVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVrJR|UxRTJwM{[zPVch|ryP NYS2THZHW0GQR1XS
DG-75 MnPsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIrnXGpKSzVyPUKuOFg2PzZizszN MmfUV2FPT0WU
HCC1143 MnnMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVzOcoVpUUN3ME2yMlUxPjV6IN88US=> MnTlV2FPT0WU
FTC-133 NIX3V5JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGHS[5pKSzVyPUKuOVM3QDlizszN MXvTRW5ITVJ?
AsPC-1 NX;1SmFyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn3vTWM2OD1{LkWzPVI6KM7:TR?= M2C4R3NCVkeHUh?=
NCI-H889 M3n4cWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXPSVI5mUUN3ME2yMlU3PzB4IN88US=> M4nFeXNCVkeHUh?=
HT55 M3[zXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnT6TWM2OD1{Lk[yNFE6KM7:TR?= NYDj[|FrW0GQR1XS
UMC-11 NFz3em9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHq4WGNKSzVyPUKuO|g4OTVizszN NFfvb5ZUSU6JRWK=
P12-ICHIKAWA NEe1NG9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1nFcGlEPTB;Mj64NlA1PiEQvF2= MXPTRW5ITVJ?
HCC1395 MluyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVzJR|UxRTJwOUi2NFIh|ryP NHLSTGFUSU6JRWK=
D-283MED NHLzS2ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MofXTWM2OD1|LkG4PVM4KM7:TR?= MWnTRW5ITVJ?
COLO-800 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{PwfGlEPTB;Mz6zN|g6PyEQvF2= MYHTRW5ITVJ?
MFM-223 NGrXRlJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MljrTWM2OD1|LkO2NFk4KM7:TR?= Ml\DV2FPT0WU
TE-5 M4jDWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFHiNI5KSzVyPUSuOVYyPDdizszN NYX4PWJ2W0GQR1XS
NCI-H209 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmDsTWM2OD12Lke4OVczKM7:TR?= MkXFV2FPT0WU
SiHa NHz6NWRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV;JR|UxRTRwOUWyNFMh|ryP NIn6TXRUSU6JRWK=
NCI-H1395 NHn0[HNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUHq[2tbUUN3ME21MlExPjN|IN88US=> NGTydm5USU6JRWK=
A498 NWn1XI1OT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mkm0TWM2OD13LkKxNlUyKM7:TR?= NWe0[3d5W0GQR1XS
ES5 M{m1RWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1TmVmlEPTB;NT62NVE4QCEQvF2= M3P2eXNCVkeHUh?=
MDA-MB-157 NGGzb2VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mlm1TWM2OD13Lk[2OFQ{KM7:TR?= MmXnV2FPT0WU
NCI-H1623 M13TSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFTyZpNKSzVyPUWuPFM2PTZizszN NFPpUIVUSU6JRWK=
RPMI-8866 MlLQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2PPT2lEPTB;NT64OFc6OiEQvF2= M4TCWXNCVkeHUh?=
LC-1F M3vVOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1XlSWlEPTB;Nj6wPVI6OSEQvF2= NGrUe25USU6JRWK=
TCCSUP MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWXzOHVOUUN3ME22MlYxOzR7IN88US=> NVizNGJRW0GQR1XS
TT Mn3uS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVG5UG5pUUN3ME24MlM{ODB7IN88US=> Ml2yV2FPT0WU
NCI-H1838 M{DUR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{nlT2lEPTB;OD61NVc{OSEQvF2= MVPTRW5ITVJ?
NCI-H322M NX[3SVlzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkfETWM2OD17LkG2NlgyKM7:TR?= NEW4OZdUSU6JRWK=
NCI-H187 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3e3T2lEPTB;OT61NVg{PSEQvF2= NGfqfGlUSU6JRWK=
SBC-1 NUPpV|dxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnPXTWM2OD17LkmzOlU3KM7:TR?= M1vaPXNCVkeHUh?=
SCC-3 NF;jU3FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3ThSWlEPTB;MUCuOVY4QSEQvF2= NY\W[XdNW0GQR1XS
SW948 M2[wS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoKyTWM2OD1zMD63OVEyKM7:TR?= MnTvV2FPT0WU
CPC-N Mnz5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUjRVlViUUN3ME2xNU4xODdizszN NEf0dFhUSU6JRWK=
TGBC24TKB MojlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{C0e2lEPTB;MUOuOVI6KM7:TR?= MWfTRW5ITVJ?
NCI-H2452 NUjxO203T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUXMbZpuUUN3ME2xOE44OyEQvF2= NFzTTmNUSU6JRWK=
Hs-578-T Moq2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWfFd3NCUUN3ME2xPE42PzV7IN88US=> NV7Scm5NW0GQR1XS
DV-90 NV3VU|lNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYPGeldQUUN3ME2xPE46QTR3IN88US=> M3:1c3NCVkeHUh?=
NCI-H1563 MlnUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH\RbFRKSzVyPUG5Mlc5QDhizszN MYnTRW5ITVJ?
SW780 Ml:wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mlr2TWM2OD1{MT6xN|E5KM7:TR?= MmXNV2FPT0WU
NCI-H345 NFj2W2VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlfoTWM2OD1{MT64O|c6KM7:TR?= M2\sbHNCVkeHUh?=
LB771-HNC MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEfDPZBKSzVyPUKyMlQ5OTNizszN NXPTUlY1W0GQR1XS
RT4 NVLyOW1sT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYP0VmtJUUN3ME2yN{4{Ojh{IN88US=> MWPTRW5ITVJ?
NCI-H82 M4nKU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mm[yTWM2OD1{Mz61OVI3KM7:TR?= NWPqeJZbW0GQR1XS
NCI-H524 MkDaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVrJR|UxRTJ2LkO4NVIh|ryP NUXjR5plW0GQR1XS
SNU-C1 MoS2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGS2TZFKSzVyPUK0MlkyODVizszN M1KzcHNCVkeHUh?=
NCI-SNU-16 M3;uOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2PRcGlEPTB;NEiuN|E1OiEQvF2= MX7TRW5ITVJ?

... Click to View More Cell Line Experimental Data

In vivo Treatment with NVP-AUY922 causes a robust antitumor response and inhibits p-Akt and VEGF expression in an HSC-2 xenograft model. [2] In BT474, NVP-AUY922 shows complete loss of ERBB2 and substantial depletion of ERα, in addition to reductions in CDK4 and phospho-ERK1/2. [3]

Protocol

Kinase Assay
+ Expand

Kinase assay:

NVP-AUY922 is dissolved in DMSO at a concentration of 10 mM. NVP-AUY922 is assessed against HSP90α, HSP90β, GRP94, TRAP-1, HSP72, and topoisomerase II. Profiling against a panel of kinases has been carried out and screening against a panel of additional enzymes and receptors is performed at Cerep.
Cell Research
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  • Cell lines: Human gastric cancer cells NCI-N87
  • Concentrations: 1 μM
  • Incubation Time: 3 days
  • Method: Human gastric cancer cells NCI-N87 (5-7 ×103 in 50 μL/well) are seeded in 96-well plates and incubated at 37 °C for 24 hours, followed by NVP-AUY922 treatment for 1-3 days at 37 °C. After treatment, the cells are assayed by MTT method and analyzed by microplate reader.
    (Only for Reference)
Animal Research
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  • Animal Models: Female NCr athymic mice bearing WM266.4 human melanoma xenografts
  • Formulation: In DMSO and diluted in sterile saline/Tween 20
  • Dosages: 50 mg/kg
  • Administration: Administered via i.v. or i.p.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 93 mg/mL (199.76 mM) warming
Ethanol 31 mg/mL (66.58 mM)
Water <1 mg/mL
In vivo 1% DMSO+30% polyethylene glycol+1% Tween 80 30 mg/mL

* 1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 465.54
Formula

C26H31N3O5

CAS No. 747412-49-3
Storage powder
in solvent
Synonyms VER-52296

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
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    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
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    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT01784640 Active, not recruiting Recurrent Non-small Cell Lung Cancer|Squamous Cell Lung Cancer|Stage IV Non-small Cell Lung Cancer Jonsson Comprehensive Cancer Center|National Cancer Institute (NCI) January 2014 Phase 1
NCT01922583 Recruiting Non-small Cell Lung Cancer (NSCLC) National Taiwan University Hospital January 2014 Phase 2
NCT01854034 Recruiting Non Small Cell Lung Cancer Massachusetts General Hospital July 2013 Phase 2
NCT01772797 Completed Anaplastic Lymphoma Kinase (ALK)|Non-small Cell Lung Cancer Novartis Pharmaceuticals|Novartis June 2013 Phase 1
NCT01752400 Active, not recruiting Non Small Cell Lung Cancer Massachusetts General Hospital January 2013 Phase 2
NCT01613950 Completed Stomach Neoplasms; Esophageal Neoplasms; Metastatic Gastric Cancer; Mutated PI3KCA Protein; Overexpressed HER2 Protein; Novartis Pharmaceuticals|Novartis December 2012 Phase 1

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

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HSP (e.g. HSP90) Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID