Luminespib (AUY-922, NVP-AUY922)

Catalog No.S1069

Luminespib (AUY-922, NVP-AUY922) is a highly potent HSP90 inhibitor for HSP90α/β with IC50 of 13 nM /21 nM in cell-free assays, weaker potency against the HSP90 family members GRP94 and TRAP-1, exhibits the tightest binding of any small-molecule HSP90 ligand. Phase 2.

Price Stock Quantity  
USD 320 In stock
USD 160 In stock
USD 270 In stock
USD 470 In stock
Bulk Inquiry

Massive Discount Available

Free Overnight Delivery on all orders over $ 500.

Luminespib (AUY-922, NVP-AUY922) Chemical Structure

Luminespib (AUY-922, NVP-AUY922) Chemical Structure
Molecular Weight: 465.54

Validation & Quality Control

3 customer reviews :

Quality Control & MSDS

Related Compound Libraries

Luminespib (AUY-922, NVP-AUY922) is available in the following compound libraries:

HSP (e.g. HSP90) Inhibitors with Unique Features

  • Selective HSP90 Inhibitor

    NVP-BEP800 HSP90β-selective, IC50=58 nM.

  • Most Potent HSP90 Inhibitor

    KW-2478 HSP90, IC50=3.8 nM.

  • HSP90 Inhibitor in Clinical Trial

    17-AAG (Tanespimycin) Phase III for Gastrointestinal Stromal Tumors.

  • Newest HSP90 Inhibitor

    XL888 ATP-competitive inhibitor of HSP90 with IC50 of 24 nM.

Product Information

  • Compare HSP (e.g. HSP90) Inhibitors
    Compare HSP (e.g. HSP90) Products
  • Research Area
  • Luminespib (AUY-922, NVP-AUY922) Mechanism

Product Description

Biological Activity

Description Luminespib (AUY-922, NVP-AUY922) is a highly potent HSP90 inhibitor for HSP90α/β with IC50 of 13 nM /21 nM in cell-free assays, weaker potency against the HSP90 family members GRP94 and TRAP-1, exhibits the tightest binding of any small-molecule HSP90 ligand. Phase 2.
Targets HSP90α [1]
(Cell-free assay)
HSP90β [1]
(Cell-free assay)
IC50 13 nM 21 nM
In vitro NVP-AUY922 inhibits proliferation of various human cancer cell lines in vitro, with an average GI50 of 9 nM. [1] The IC50 values of NVP-AUY922 fall in the range of 2 to 40 nM in these gastric cancer cell lines. IC50 value for the BEAS-2B cells is 28.49 nM. Treatment with NVP-AUY922 does not influence the expression of HSP90, but expression of HSP70 gets elevated by NVP-AUY922 treatment. NVP-AUY922 increases the binding of HSP70 to HSP90. NVP-AUY922 causes p23 dissociation from the HSP90 complex and can then recruit HSP70 to the HSP90 complex. [1] After the treatment with NVP-AUY922, expression of receptor tyrosine kinases including VEGFR1, 2, 3 and PDGFRɑ is decreased. A decrease is also noticed in the expression of Akt and phospho-Akt. Meanwhile, treatment with NVP-AUY922 causes decreased expression of HER-2 in NCI-N87 cells. NVP-AUY922 treatment results in binding of HSP90 to client proteins and setting them up as targets for degradation by the proteasome. NVP-AUY922 can influence cell growth by affecting multiple signaling pathways. In addition, treatment with the proteasome inhibitor, MG132, restores expression of thymidylate synthase, which is decreased by NVP-AUY922. NVP-AUY922 increases the expression of cleaved caspase-3 leading to apoptosis in HSC-2 cells.[1]
Cell Data
Cell LinesAssay TypeConcentrationIncubation TimeFormulationActivity DescriptionPMID
CMKMmH3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NYP3ZpFRUUN3ME2wMlAxODF{NTFOwG0>MmOxV2FPT0WU
MV-4-11NH25OZlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NH;DVG9KSzVyPUCuNFAxPTV6IN88US=>NEfsO|dUSU6JRWK=
NALM-6M1vVXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MVjJR|UxRTBwMECwPFQzKM7:TR?=NYTGSJFnW0GQR1XS
HOSM4jRO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7NXLnOGk1UUN3ME2wMlAxOTN6IN88US=>Mki1V2FPT0WU
HT-144MlHFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M3;VbmlEPTB;MD6wNFE2PSEQvF2=NGnRc|VUSU6JRWK=
SW1710NYfzfWY3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M2ixPWlEPTB;MD6wNFE5PiEQvF2=M{Tq[3NCVkeHUh?=
TE-8NY\LXlFPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NYDvfYdGUUN3ME2wMlAxOjN5IN88US=>NYrEO3p5W0GQR1XS
ES1M4rWfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MYXJR|UxRTBwMECyOlYh|ryPM{ThN3NCVkeHUh?=
CCF-STTG1Mm\CS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NHL6[4RKSzVyPUCuNFAzQTdizszNNGLqe2lUSU6JRWK=
PSN1NXnSXY1VT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MoDpTWM2OD1yLkCwN|E5KM7:TR?=MUDTRW5ITVJ?
CAL-51MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M2\JS2lEPTB;MD6wNFMzPSEQvF2=NX3tSXo2W0GQR1XS
MCF7MljIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NW[y[3doUUN3ME2wMlAxOzN3IN88US=>M1vleHNCVkeHUh?=
SK-HEP-1MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M{XvbmlEPTB;MD6wNFM{PiEQvF2=NYjNWHBzW0GQR1XS
LCLC-103HMmHIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MmP3TWM2OD1yLkCwOFMh|ryPNGe5fpZUSU6JRWK=
HMV-IIMVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MX3JR|UxRTBwMEC0OFkh|ryPNFHZephUSU6JRWK=
MES-SAM13IZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MWfJR|UxRTBwMEC0OVIh|ryPMoj2V2FPT0WU
SK-LMS-1NVrRNI5GT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M3PIb2lEPTB;MD6wNFQ2QCEQvF2=NITBepJUSU6JRWK=
639-VM334Wmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MX7JR|UxRTBwMEC0PFUh|ryPMnrBV2FPT0WU
SIG-M5M13abmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NFy4fYlKSzVyPUCuNFA1QDlizszNMn\PV2FPT0WU
LOUCYMoPGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NFfmcmZKSzVyPUCuNFA2ODVizszNNVrGXGc6W0GQR1XS
HSC-2MnnBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M2izbmlEPTB;MD6wNFUyQCEQvF2=NYTBUmpxW0GQR1XS
EW-13M2TNfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NHPEeGdKSzVyPUCuNFA2OThizszNM{jnenNCVkeHUh?=
RT-112NInqTmdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MlrRTWM2OD1yLkCwOVM2KM7:TR?=Mnf1V2FPT0WU
NKM-1NULrVGZRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M{TzT2lEPTB;MD6wNFU1PyEQvF2=MlXJV2FPT0WU
KYSE-180MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NHzPXo1KSzVyPUCuNFA2QDZizszNMYHTRW5ITVJ?
SW1783NX;Y[mxxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M{Llb2lEPTB;MD6wNFU6OSEQvF2=MnnlV2FPT0WU
A431Mn\RS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MYPJR|UxRTBwMEC2NFch|ryPNHLI[JVUSU6JRWK=
SK-OV-3MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NGq3THhKSzVyPUCuNFA3OyEQvF2=NYDWRlV6W0GQR1XS
RPMI-7951MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NILpeIxKSzVyPUCuNFA3OzFizszNNVrOXJB1W0GQR1XS
Capan-2MlO5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NVXqTYFtUUN3ME2wMlAxPjN6IN88US=>NWfld|UyW0GQR1XS
HSC-3MnXWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NF74bI1KSzVyPUCuNFA3PDFizszNMVXTRW5ITVJ?
786-0NXXGdIllT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=Mn3oTWM2OD1yLkCwOlY{KM7:TR?=M4L1NHNCVkeHUh?=
DaoyMUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M3TGfGlEPTB;MD6wNFY6PSEQvF2=M2rHNXNCVkeHUh?=
KGNMXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MWfJR|UxRTBwMEC3NFMh|ryPNULwRoJxW0GQR1XS
EW-16NXnvUopwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NVPOTo9IUUN3ME2wMlAxPzR7IN88US=>M2fPT3NCVkeHUh?=
EW-7M4nLe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7M4nRb2lEPTB;MD6wNFc2PCEQvF2=MWLTRW5ITVJ?
IGROV-1Mm[4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NF\mbmZKSzVyPUCuNFA5OTRizszNMnzkV2FPT0WU
8505CMke3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NYTZNFZSUUN3ME2wMlAxQDJzIN88US=>M4LWbXNCVkeHUh?=
RKONWqzUI57T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NGfwXIpKSzVyPUCuNFA5OjZizszNNX3Xe2VJW0GQR1XS
GDM-1M1LUcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NWnWZY9JUUN3ME2wMlAxQDRizszNNXLMXGp2W0GQR1XS
IST-MEL1MnjOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NGjhfGNKSzVyPUCuNFA5PTJizszNMmPWV2FPT0WU
RPMI-6666MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M{DadGlEPTB;MD6wNFg2OiEQvF2=MlHMV2FPT0WU
SNG-MMn\sS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M2izSWlEPTB;MD6wNFg2PiEQvF2=NXjKb3k4W0GQR1XS
KS-1NXnIUmRqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MUXJR|UxRTBwMEC4OVkh|ryPMV3TRW5ITVJ?
RXF393MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M2LY[GlEPTB;MD6wNFg3KM7:TR?=NUW2[WVOW0GQR1XS
CAL-12TNH;Yb2FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M2nXSGlEPTB;MD6wNFkzOiEQvF2=MWPTRW5ITVJ?
BFTC-905MnHXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MVTJR|UxRTBwMEC5N|gh|ryPNXjUXGpsW0GQR1XS
SK-MES-1MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MlPaTWM2OD1yLkCwPVQ2KM7:TR?=MXTTRW5ITVJ?
BB30-HNCMnjRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MnnoTWM2OD1yLkCwPVUzKM7:TR?=NHf1T2xUSU6JRWK=
AN3-CANYPUOmpGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NF;hN|lKSzVyPUCuNFExOTdizszNNI\2fplUSU6JRWK=
EFO-27NHz2RYxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NVPjPVhRUUN3ME2wMlAyODF5IN88US=>M4riVHNCVkeHUh?=
G-401NIPk[IlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NUL5W2xvUUN3ME2wMlAyODJ3IN88US=>MkPDV2FPT0WU
BPH-1NUDCVpJHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MkO1TWM2OD1yLkCxNFMh|ryPNWLRe|dyW0GQR1XS
NCI-H727NUXyN|dwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NEjKdYFKSzVyPUCuNFExOyEQvF2=MmrnV2FPT0WU
SNU-423M{LLS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7NFnyWFBKSzVyPUCuNFExPTNizszNM4\pWXNCVkeHUh?=
KYSE-270Ml\CS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NVqxcm9UUUN3ME2wMlAyODV7IN88US=>Ml;kV2FPT0WU
AGSM3jvR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7NX\1TGpOUUN3ME2wMlAyODZzIN88US=>MV7TRW5ITVJ?
NCI-H2228NH7VO4RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M3;OcmlEPTB;MD6wNVA3PCEQvF2=M{WwcHNCVkeHUh?=
SW954M33Yd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7NHzq[mpKSzVyPUCuNFExPzFizszNNGnJdnNUSU6JRWK=
769-PNHnmXZVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MVfJR|UxRTBwMEGwO|Mh|ryPNHnnc|JUSU6JRWK=
BB49-HNCM3XtNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M3\WbWlEPTB;MD6wNVA4PyEQvF2=MkO3V2FPT0WU
IA-LMMX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NI\6Z29KSzVyPUCuNFExQDZizszNNFzxNVVUSU6JRWK=
NB69NU\MPWg1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NG[xPY1KSzVyPUCuNFEyODJizszNNVnoTopVW0GQR1XS
C8166NWTzbpRMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M2DZOGlEPTB;MD6wNVEzQSEQvF2=NIDPVWtUSU6JRWK=
NCI-H1299NHnT[plIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MmTVTWM2OD1yLkCxNVU1KM7:TR?=NE\FTJFUSU6JRWK=
YKG-1MnjhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?Mo\uTWM2OD1yLkCxNVYh|ryPMn;RV2FPT0WU
PANC-03-27NYnjfnF4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MkG5TWM2OD1yLkCxNVYzKM7:TR?=NFzjOYdUSU6JRWK=
YTNEn4fHBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MV3JR|UxRTBwMEGxO|kh|ryPNHz5[Y9USU6JRWK=
CAL-85-1MmTOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MX\JR|UxRTBwMEGxPVIh|ryPNWPQbWkyW0GQR1XS
GT3TKBNXnzOm9bT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NHnnb4tKSzVyPUCuNFEzODJizszNNHrMVlBUSU6JRWK=
BB65-RCCM{jYUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MYrJR|UxRTBwMEGyNFQh|ryPNHPqNFhUSU6JRWK=
ES6NVjZNmhNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MVfJR|UxRTBwMEGyOlEh|ryPNVTHc5FtW0GQR1XS
MHH-ES-1Ml\HS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MlzJTWM2OD1yLkCxNlY{KM7:TR?=NGf0fWdUSU6JRWK=
QIMR-WILMlziS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MlvtTWM2OD1yLkCxNlY6KM7:TR?=MWrTRW5ITVJ?
SNU-C2BNX;WcodtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=Ml;STWM2OD1yLkCxNlczKM7:TR?=NWfUfJFYW0GQR1XS
OCI-AML2M4LUN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7NFTvT29KSzVyPUCuNFEzQDFizszNM3\sSHNCVkeHUh?=
DU-145NW\EOpJwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NVrJc|E6UUN3ME2wMlAyOjlizszNNXLYOppMW0GQR1XS
SW982NE\1dGxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MofwTWM2OD1yLkCxNlk{KM7:TR?=NHjh[HpUSU6JRWK=
MFH-inoMUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?Mlr2TWM2OD1yLkCxNlk{KM7:TR?=MojSV2FPT0WU
A427M3HnUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NWHRS2xMUUN3ME2wMlAyOjl7IN88US=>M3\jUnNCVkeHUh?=
LCLC-97TM1MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NUjzd3NqUUN3ME2wMlAyOyEQvF2=MoDtV2FPT0WU
AM-38MnjnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NUnMUmtvUUN3ME2wMlAyOzB{IN88US=>NV3xfY5yW0GQR1XS
K5NV65TIY5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NED3cVNKSzVyPUCuNFE{ODhizszNMXHTRW5ITVJ?
T84MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NHvrRXdKSzVyPUCuNFE{OzFizszNM4\HVHNCVkeHUh?=
TE-15MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M1u3VGlEPTB;MD6wNVM{PiEQvF2=MUTTRW5ITVJ?
NCI-H460MkT1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MW\JR|UxRTBwMEGzN|Yh|ryPMXvTRW5ITVJ?
NTERA-S-cl-D1MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NWrC[WFPUUN3ME2wMlAyOzN7IN88US=>MVTTRW5ITVJ?
KYSE-450Mn34S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MlznTWM2OD1yLkCxN|Q6KM7:TR?=NXnEO21ZW0GQR1XS
H4MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NYrVVG5jUUN3ME2wMlAyOzZ4IN88US=>MXzTRW5ITVJ?
LC-2-adM1r6NWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7Ml;YTWM2OD1yLkCxN|ch|ryPMlvuV2FPT0WU
GAMGNFuwRpZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MnHXTWM2OD1yLkCxN|cyKM7:TR?=MVTTRW5ITVJ?
TK10NYfEVlh{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M{C0VGlEPTB;MD6wNVM5OiEQvF2=NX;NV2NGW0GQR1XS
NCI-H2122MoLCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NVrxV3lPUUN3ME2wMlAyOzh2IN88US=>NWHxV4pxW0GQR1XS
KM12NUPwVHk6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MVPJR|UxRTBwMEGzPVkh|ryPMm\ZV2FPT0WU
CAL-39M{HaU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7NHHP[olKSzVyPUCuNFE1OiEQvF2=MV\TRW5ITVJ?
RPMI-2650MlTES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MVrJR|UxRTBwMEG0N|Ih|ryPNGjQNplUSU6JRWK=
KYSE-510NYrGZ2Q6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NHHD[JBKSzVyPUCuNFE1PDJizszNM37qW3NCVkeHUh?=
KALS-1NVrL[4JtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MYHJR|UxRTBwMEG0OlYh|ryPMWjTRW5ITVJ?
NCI-H1648NYXveJljT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NEiwVGhKSzVyPUCuNFE1QTlizszNNXexNpBPW0GQR1XS
ES4MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NWPzRlhzUUN3ME2wMlAyPTB{IN88US=>M1mxdnNCVkeHUh?=
C-33-AMX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NFXPOplKSzVyPUCuNFE2ODlizszNNWniO3V5W0GQR1XS
MIA-PaCa-2NUPYNoFVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NUP2dmN4UUN3ME2wMlAyPTB7IN88US=>MYHTRW5ITVJ?
BeckerNXO2OYtzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MVfJR|UxRTBwMEG1NVQh|ryPNUm3O3hGW0GQR1XS
HOP-62MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M{HrZmlEPTB;MD6wNVU1OiEQvF2=M17Rd3NCVkeHUh?=
TE-1NYPFdoJET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M1PqdGlEPTB;MD6wNVU5OSEQvF2=NGnte|dUSU6JRWK=
KYSE-410M3rHSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MY\JR|UxRTBwMEG1PFYh|ryPNIXZOVBUSU6JRWK=
NOS-1NWnxc4k4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=Mnj1TWM2OD1yLkCxOVk{KM7:TR?=M4HIRXNCVkeHUh?=
MEL-HOMWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MkLlTWM2OD1yLkCxOlQ{KM7:TR?=MXLTRW5ITVJ?
NCI-H1650NWnmW|FyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MXfJR|UxRTBwMEG2OFYh|ryPNWLkOXNxW0GQR1XS
VMRC-RCZMWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M2qwZWlEPTB;MD6wNVY2OSEQvF2=M4PpeHNCVkeHUh?=
HuP-T3M{fxOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7Mor1TWM2OD1yLkCxOlU{KM7:TR?=NGLjO5dUSU6JRWK=
ACNM3;wV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7MV\JR|UxRTBwMEG2OVch|ryPMljHV2FPT0WU
MEL-JUSOMnqwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NF71V3ZKSzVyPUCuNFE3QDFizszNMlPGV2FPT0WU
HT-1197MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NEDMWZZKSzVyPUCuNFE3QDVizszNMofIV2FPT0WU
NCI-H2030NXHWNXlMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NHLpUYFKSzVyPUCuNFE3QTdizszNMX;TRW5ITVJ?
A4-FukM3;y[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7MWjJR|UxRTBwMEG3NFIh|ryPNXfVb3JJW0GQR1XS
NCI-H292M3G3NGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MWTJR|UxRTBwMEG3NFkh|ryPNWDYUmN{W0GQR1XS
A2780MkjlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MUHJR|UxRTBwMEG3NVUh|ryPM1;jSnNCVkeHUh?=
SF295NILt[WJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NX3IV25lUUN3ME2wMlAyPzJzIN88US=>M3TLfnNCVkeHUh?=
NCI-H810MkXwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MmrhTWM2OD1yLkCxO|I1KM7:TR?=MljIV2FPT0WU
ALL-PONEX2VXBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M124cWlEPTB;MD6wNVc{PSEQvF2=MYnTRW5ITVJ?
MC-IXCM3LiZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M3vWSmlEPTB;MD6wNVc{PiEQvF2=MUPTRW5ITVJ?
NYNEjNVW5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NIXyWFJKSzVyPUCuNFE4PCEQvF2=MUPTRW5ITVJ?
OMC-1M{TVZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7Mmm3TWM2OD1yLkCxO|UyKM7:TR?=MWnTRW5ITVJ?
PANC-10-05MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NGm5XHRKSzVyPUCuNFE4PTVizszNNHHX[pFUSU6JRWK=
NCI-H2342M2\Wc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7NWrMdVY{UUN3ME2wMlAyPzV6IN88US=>M3Pwb3NCVkeHUh?=
HGC-27NFSyenFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M3S1OWlEPTB;MD6wNVc2QCEQvF2=MkDzV2FPT0WU
TE-12NWLlT5FTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MnjCTWM2OD1yLkCxO|c2KM7:TR?=NYfIRY17W0GQR1XS
MOLT-16M{XOeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MnPKTWM2OD1yLkCxO|g5KM7:TR?=NHTVbGFUSU6JRWK=
HL-60M2\BZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NEPWU4JKSzVyPUCuNFE5ODdizszNMUHTRW5ITVJ?
OVCAR-5NYj4SVJ5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MWfJR|UxRTBwMEG4NVIh|ryPM2Pkc3NCVkeHUh?=
SK-LU-1Mn\CS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M2nUWmlEPTB;MD6wNVg1PiEQvF2=MUHTRW5ITVJ?
MG-63NFH5VGlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NV7z[2F2UUN3ME2wMlAyQDd2IN88US=>M2rjbXNCVkeHUh?=
8-MG-BANGTKbXZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NYO0Vm1yUUN3ME2wMlAyQDh2IN88US=>MYnTRW5ITVJ?
COR-L105NHnhemdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M{j1bWlEPTB;MD6wNVkyOSEQvF2=NVO0WHljW0GQR1XS
BHYNInqb2VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M{PNNmlEPTB;MD6wNVkyOiEQvF2=M2f5XXNCVkeHUh?=
SW620M{jGUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NHjFVmdKSzVyPUCuNFE6OTVizszNMVvTRW5ITVJ?
PC-14MkDMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MXzJR|UxRTBwMEG5N|Qh|ryPM1Gyb3NCVkeHUh?=
NCI-H522M2LpRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MWjJR|UxRTBwMEG5N|kh|ryPNYq3S5U1W0GQR1XS
OE19NGHRcIpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MWXJR|UxRTBwMEG5OUDPxE1?M174UnNCVkeHUh?=
RVH-421MoTJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MlS1TWM2OD1yLkCxPVU4KM7:TR?=MoXtV2FPT0WU
TE-10MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NFjtRWhKSzVyPUCuNFE6PzdizszNM3TjVHNCVkeHUh?=
A101DMXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M1LnVmlEPTB;MD6wNVk5PyEQvF2=Ml;ZV2FPT0WU
HUTU-80MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NIjPS|BKSzVyPUCuNFIxODRizszNNIXLNHNUSU6JRWK=
KYSE-140MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MmXwTWM2OD1yLkCyNFI1KM7:TR?=NYqzOGM2W0GQR1XS
SNU-449MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M4X6UGlEPTB;MD6wNlAzPiEQvF2=M3e3OHNCVkeHUh?=
697MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NHnOUmZKSzVyPUCuNFIxOzFizszNMVjTRW5ITVJ?
SJSA-1Mk\5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NYDQZXhkUUN3ME2wMlAzODN5IN88US=>MUXTRW5ITVJ?
IGR-1NIrnbY5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NGix[4VKSzVyPUCuNFIxPSEQvF2=MlLzV2FPT0WU
GCIYM4HCRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NWPPWFFsUUN3ME2wMlAzODV3IN88US=>Mn3sV2FPT0WU
REHM1rDemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MoLvTWM2OD1yLkCyNFU6KM7:TR?=MnTyV2FPT0WU
A204MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?Ml3STWM2OD1yLkCyNVE2KM7:TR?=NViyU5lXW0GQR1XS
A388NFrMfWxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M4W0bWlEPTB;MD6wNlEyPSEQvF2=NFvMXYVUSU6JRWK=
NCI-H650M{faZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7M2n4XmlEPTB;MD6wNlEyPyEQvF2=M1PyeXNCVkeHUh?=
SW626M1rxRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M3rRbGlEPTB;MD6wNlEzKM7:TR?=MYrTRW5ITVJ?
DoTc2-4510M17lbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M3;4d2lEPTB;MD6wNlEzOiEQvF2=MkjyV2FPT0WU
HCE-4NEnOPGVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NIXP[WpKSzVyPUCuNFIyPDVizszNMkHnV2FPT0WU
DU-4475MkTTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NYq0fnJzUUN3ME2wMlAzOTVizszNNUD2[4pHW0GQR1XS
A375MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MUfJR|UxRTBwMEKxO|Eh|ryPM13mTXNCVkeHUh?=
GB-1NYnIUmo6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MlXCTWM2OD1yLkCyNVg5KM7:TR?=NWLpZllsW0GQR1XS
CHP-212MmD0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M4fTfGlEPTB;MD6wNlIyOiEQvF2=MlLVV2FPT0WU
HT-1080NXvqNmRET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M{[3cmlEPTB;MD6wNlIyPCEQvF2=NF7kTpdUSU6JRWK=
M059JNGjifZVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M{TXcGlEPTB;MD6wNlI1OSEQvF2=M4TrS3NCVkeHUh?=
NMC-G1NEXvV2xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NF3jO5hKSzVyPUCuNFIzQCEQvF2=NUn5W4FrW0GQR1XS
MRK-nu-1Mnz0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M4Dib2lEPTB;MD6wNlMh|ryPMWDTRW5ITVJ?
MFE-296NXLESYVkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M2LUc2lEPTB;MD6wNlMzOiEQvF2=MmTuV2FPT0WU
LOXIMVIMVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M2TnTmlEPTB;MD6wNlMzOyEQvF2=MWnTRW5ITVJ?
CGTH-W-1NXr0b493T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NGPQTGFKSzVyPUCuNFI{OjhizszNNE\DZVZUSU6JRWK=
CCRF-CEMMX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?Moq2TWM2OD1yLkCyN|I6KM7:TR?=M2\tenNCVkeHUh?=
ACHNMlfsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NEDvcZVKSzVyPUCuNFI{PDVizszNM365NXNCVkeHUh?=
NCI-H1355MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NXrlZpFNUUN3ME2wMlAzPDBzIN88US=>NFLYNlRUSU6JRWK=
NCI-H1651MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M2TCVGlEPTB;MD6wNlQ{OSEQvF2=NH;5cZlUSU6JRWK=
KINGS-1MlPKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NHzrbYxKSzVyPUCuNFI1OzNizszNM3HkVnNCVkeHUh?=
LS-123NXu4O4ZWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NF3DZmFKSzVyPUCuNFI1OzVizszNM4nSd3NCVkeHUh?=
SNB75NVTV[mE5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=Ml7xTWM2OD1yLkCyOFY3KM7:TR?=NUTpTHIyW0GQR1XS
C3AM1PubGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M1\RNWlEPTB;MD6wNlQ4PSEQvF2=NHLCXZZUSU6JRWK=
HO-1-N-1MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MVLJR|UxRTBwMEK1OFkh|ryPMlLFV2FPT0WU
EHEBM123d2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7MXvJR|UxRTBwMEK1OVUh|ryPM4jEWXNCVkeHUh?=
CAL-62Ml;PS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NXiybIhjUUN3ME2wMlAzPTdizszNM4fHNXNCVkeHUh?=
U-118-MGMVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MUnJR|UxRTBwMEK1O|Yh|ryPMk\BV2FPT0WU
HNMVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MkDHTWM2OD1yLkCyOVk{KM7:TR?=NX;Vdm5TW0GQR1XS
HTC-C3NHzFTFJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NIDPWoZKSzVyPUCuNFI3ODdizszNMkDCV2FPT0WU
KYSE-520NWrmS2U{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NWL5c2dZUUN3ME2wMlAzPjF|IN88US=>MlrpV2FPT0WU
MZ1-PCNYjtbHFUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MUjJR|UxRTBwMEK2N|kh|ryPMV\TRW5ITVJ?
BCPAPM1Lhb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7M3HXUGlEPTB;MD6wNlY1PiEQvF2=MlHsV2FPT0WU
RDNIi0RXRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NYHsXllbUUN3ME2wMlAzPjV6IN88US=>NGXk[HNUSU6JRWK=
NCI-H520MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MYDJR|UxRTBwMEK2OlQh|ryPMoPGV2FPT0WU
LXF-289NXPYSopsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NEXneZZKSzVyPUCuNFI3PjhizszNM1nLTHNCVkeHUh?=
G-361M3jWeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MVrJR|UxRTBwMEK2O|ch|ryPNEfMbZBUSU6JRWK=
LB996-RCCNULib2ZJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NYHFOJhuUUN3ME2wMlAzPzFizszNNYfGcGhlW0GQR1XS
COR-L23NYTEVoFRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MXPJR|UxRTBwMEK3NVMh|ryPMmjpV2FPT0WU
GP5dM{\XOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NWXifoZ2UUN3ME2wMlAzPzJ|IN88US=>NFXvN2ZUSU6JRWK=
SW1990MknqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NELPfZhKSzVyPUCuNFI4OjRizszNMYXTRW5ITVJ?
PA-1NF7ER4ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NXT6RWxIUUN3ME2wMlAzPzV3IN88US=>NInkTmdUSU6JRWK=
NCI-H2009NI\1N2lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NGLQbVZKSzVyPUCuNFI4PiEQvF2=NUO0XFk3W0GQR1XS
SRM2Gy[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7MlW5TWM2OD1yLkCyO|g2KM7:TR?=M{HwNHNCVkeHUh?=
Ca9-22M1;wTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M{HLbWlEPTB;MD6wNlc6PiEQvF2=NUnQNIhUW0GQR1XS
SCC-15MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NWi0UHNUUUN3ME2wMlAzQDBzIN88US=>NHLUOZlUSU6JRWK=
ETK-1NFrI[ndIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NXrNb2h4UUN3ME2wMlAzQDB4IN88US=>NYK3N401W0GQR1XS
SCC-4MoLpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MmjkTWM2OD1yLkCyPFA6KM7:TR?=MWXTRW5ITVJ?
5637NX7yfI1DT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NIqxcWRKSzVyPUCuNFI5OjJizszNMkH4V2FPT0WU
EW-1NIjsNldIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MW\JR|UxRTBwMEK4NlIh|ryPM4O3O3NCVkeHUh?=
SW962M4LXR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7MULJR|UxRTBwMEK4OVIh|ryPMn33V2FPT0WU
HCE-TM{SzPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M3HEN2lEPTB;MD6wNlg3KM7:TR?=NHv6fYtUSU6JRWK=
NCI-H2405NHjBSolIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M3vUWWlEPTB;MD6wNlg5PyEQvF2=NYjZWWNDW0GQR1XS
A2058MkfjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NV\BfYpyUUN3ME2wMlAzQTJ7IN88US=>MVHTRW5ITVJ?
HCC2998NWfrNJRxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MoTPTWM2OD1yLkCyPVQ2KM7:TR?=NYDqV3pJW0GQR1XS
ONS-76MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MXHJR|UxRTBwMEK5OVQh|ryPNIjWNpJUSU6JRWK=
DBTRG-05MGNWTsfG9QT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MW\JR|UxRTBwMEK5OVUh|ryPMkm0V2FPT0WU
HuCCT1M2HPcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MmP4TWM2OD1yLkCyPVYyKM7:TR?=NH3RW2lUSU6JRWK=
J82NUO5eXp2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MkXlTWM2OD1yLkCzNFA4KM7:TR?=M4f5dXNCVkeHUh?=
MKN28NH3MT3pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MnvBTWM2OD1yLkCzNFEzKM7:TR?=M{LZSnNCVkeHUh?=
SW837MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MXXJR|UxRTBwMEOwNVQh|ryPNWntWY9xW0GQR1XS
no-10M2fFU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7NV:3[mlpUUN3ME2wMlA{ODF4IN88US=>MYTTRW5ITVJ?
BC-3MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M4i2WGlEPTB;MD6wN|AyQCEQvF2=NXjwVlk4W0GQR1XS
no-11Mm\2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MlTsTWM2OD1yLkCzNFQ5KM7:TR?=M3jPZ3NCVkeHUh?=
8305CMV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NIPYW2hKSzVyPUCuNFMxPzJizszNM1;COnNCVkeHUh?=
COLO-679M4nDOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NWfTTnM3UUN3ME2wMlA{OTB5IN88US=>M4HOTXNCVkeHUh?=
CESSNWjRWWYyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M4PJSWlEPTB;MD6wN|EzKM7:TR?=MojMV2FPT0WU
BFTC-909NEDaTZJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NGjLbFZKSzVyPUCuNFMyOjVizszNMn;GV2FPT0WU
MZ2-MELM3nObmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MkPBTWM2OD1yLkCzNVc4KM7:TR?=NXTWWFVWW0GQR1XS
SW872Mny5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NWjOSWNuUUN3ME2wMlA{OjF5IN88US=>M1vnOXNCVkeHUh?=
LB831-BLCNF\RUWdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M{\Be2lEPTB;MD6wN|IyQSEQvF2=MYnTRW5ITVJ?
SK-UT-1NWDCTVRNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NF[yWXVKSzVyPUCuNFMzOjFizszNNHvwV3FUSU6JRWK=
NCI-H1734NVnkeolkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NWnJVFVkUUN3ME2wMlA{OjNizszNNWTvRlZSW0GQR1XS
OVCAR-8NXvYUJNuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MmLWTWM2OD1yLkCzNlgyKM7:TR?=MXfTRW5ITVJ?
NCI-H2087Ml;xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NUniOYdIUUN3ME2wMlA{Ojh7IN88US=>MY\TRW5ITVJ?
U-87-MGMlz3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MU\JR|UxRTBwMEOyPUDPxE1?NV:wXG9vW0GQR1XS
BC-1MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MoTxTWM2OD1yLkCzN|Y4KM7:TR?=MmXKV2FPT0WU
ES7MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NWDPZ3VWUUN3ME2wMlA{Ozd2IN88US=>MXLTRW5ITVJ?
DaudiM2[wc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7NX7Rfpo{UUN3ME2wMlA{Ozd4IN88US=>NVvOdpg5W0GQR1XS
RS4-11NXzLTolNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NIDydplKSzVyPUCuNFM{QDNizszNMnjWV2FPT0WU
JiyoyeP-2003MoTxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NV7sd|ZyUUN3ME2wMlA{Ozh6IN88US=>NW\IdpZTW0GQR1XS
BL-70MnvZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NV\kUJVLUUN3ME2wMlA{Ozh7IN88US=>MXLTRW5ITVJ?
OS-RC-2NV;xUm5sT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M37UUGlEPTB;MD6wN|M6PiEQvF2=Ml;nV2FPT0WU
SF268M1HITmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M2DqTmlEPTB;MD6wN|QxOSEQvF2=NICzN5BUSU6JRWK=
BV-173NXq3NWVXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=Mnr4TWM2OD1yLkCzOFI3KM7:TR?=NVLXOFR4W0GQR1XS
DMS-273NW\QR3VQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NFXVO2NKSzVyPUCuNFM1PzlizszNNHnpOVZUSU6JRWK=
22RV1M3\Jdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MY\JR|UxRTBwMEO1NFch|ryPNHP3bGFUSU6JRWK=
ES8NIXjW4FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M3rCVmlEPTB;MD6wN|U{QCEQvF2=NE\VNWhUSU6JRWK=
KYSE-150NXKxW2lLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MUTJR|UxRTBwMEO2NFgh|ryPNVHHWog5W0GQR1XS
HCC1569M3\ReWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M4fQeWlEPTB;MD6wN|YxQCEQvF2=NGfUNnJUSU6JRWK=
NB5NY\B[plDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=Mk\LTWM2OD1yLkCzOlE{KM7:TR?=MkmzV2FPT0WU
G-402MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M2fyeWlEPTB;MD6wN|YyPCEQvF2=MmrjV2FPT0WU
NCI-H1693MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NYLTTWp3UUN3ME2wMlA{PjF5IN88US=>NFfsWVRUSU6JRWK=
LB2241-RCCNIezcFVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M2fiOmlEPTB;MD6wN|Y1OiEQvF2=M17TXnNCVkeHUh?=
KP-4MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NH71N2lKSzVyPUCuNFM3PjNizszNMUnTRW5ITVJ?
ML-2M{P5[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7MmLBTWM2OD1yLkCzOlcyKM7:TR?=MWrTRW5ITVJ?
KU812Ml\aS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MXHJR|UxRTBwMEO2PFQh|ryPM1HNdXNCVkeHUh?=
LS-411NM3j4UWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NYXD[pA4UUN3ME2wMlA{PzNzIN88US=>NVTNRo02W0GQR1XS
OAW-42NVfiWZVNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NX\tc41HUUN3ME2wMlA{PzR5IN88US=>NHzmdWpUSU6JRWK=
HCC38NIP6NZJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MV\JR|UxRTBwMEO3O|Eh|ryPM1zjU3NCVkeHUh?=
Ca-SkiMVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M17ZfGlEPTB;MD6wN|c5PCEQvF2=MlLjV2FPT0WU
Calu-3NHjK[2tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M2T5dmlEPTB;MD6wN|c5QSEQvF2=MU\TRW5ITVJ?
KYSE-70NIS0VGlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M1O2SmlEPTB;MD6wN|gyOiEQvF2=NGPWPXRUSU6JRWK=
D-392MGMXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?Mn6zTWM2OD1yLkCzPFQzKM7:TR?=NUno[3g1W0GQR1XS
OVCAR-4MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NHPBZmlKSzVyPUCuNFM5PThizszNM4nLN3NCVkeHUh?=
Detroit562NYf1N4xQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MVHJR|UxRTBwMEO4O|Ih|ryPNYDi[nRmW0GQR1XS
HELMWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NY[zfmNUUUN3ME2wMlA{QDlzIN88US=>MVrTRW5ITVJ?
MONO-MAC-6MlrBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NF\DcG9KSzVyPUCuNFM5QTNizszNNYXMWY5GW0GQR1XS
LoVoMlXSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MVnJR|UxRTBwMEO5N|Mh|ryPMnzBV2FPT0WU
U-2-OSNXzqd|JTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MXjJR|UxRTBwMEO5N|Uh|ryPMn22V2FPT0WU
A172MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MVzJR|UxRTBwMEO5OUDPxE1?MkT0V2FPT0WU
OCUB-MMn3SS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NWT5d2lRUUN3ME2wMlA{QTZzIN88US=>MoT2V2FPT0WU
SW48NIrUfVdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NFHCWoVKSzVyPUCuNFQxOzFizszNM3vzW3NCVkeHUh?=
HC-1M3LFO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7M17OV2lEPTB;MD6wOFA3QSEQvF2=NV\HeVBGW0GQR1XS
KOSC-2NILK[ZFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NYLIWno{UUN3ME2wMlA1OTFizszNNIPMd45USU6JRWK=
HDLM-2NHrrVY5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MWfJR|UxRTBwMESxNVQh|ryPNGj0fFZUSU6JRWK=
CTV-1NXnTOmdlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MWnJR|UxRTBwMESxNVYh|ryPMUHTRW5ITVJ?
SH-4MorRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?Mln3TWM2OD1yLkC0NVQyKM7:TR?=MnzmV2FPT0WU
SW756MmHhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NF3Eb2lKSzVyPUCuNFQyPTdizszNNXvrOY1YW0GQR1XS
GCTM2fLeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NHnkWJVKSzVyPUCuNFQyPjFizszNM1y5NXNCVkeHUh?=
CHL-1M{LIRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MUPJR|UxRTBwMESxOlkh|ryPNGnScGRUSU6JRWK=
LAMA-84NF7reVJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M4nodWlEPTB;MD6wOFE4OSEQvF2=NXPwZ|A3W0GQR1XS
LS-1034MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NF25RVhKSzVyPUCuNFQyQTFizszNNY\5WJZ4W0GQR1XS
NCI-H358MnL3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NY\1RnhmUUN3ME2wMlA1OjF{IN88US=>MULTRW5ITVJ?
NB13M2jCSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MWTJR|UxRTBwMESyNlch|ryPNUPYTWI4W0GQR1XS
TE-9NIe2eYVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NGLZeVlKSzVyPUCuNFQzOzdizszNNXrIb|h6W0GQR1XS
OE33NW[0bmtwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MV3JR|UxRTBwMESyOFEh|ryPM33ySnNCVkeHUh?=
CAL-120MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M1r5PGlEPTB;MD6wOFI1OSEQvF2=M2DBO3NCVkeHUh?=
DJM-1M{HSTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NXHsSmt1UUN3ME2wMlA1Ojd{IN88US=>M3\RWHNCVkeHUh?=
SK-MEL-24M3WyeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NEnLVI5KSzVyPUCuNFQzQDNizszNNXf2[4wxW0GQR1XS
VA-ES-BJNF2zU2FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MoL1TWM2OD1yLkC0NlkzKM7:TR?=MoLLV2FPT0WU
MMAC-SFNEXPeppIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M{m0U2lEPTB;MD6wOFI6PyEQvF2=NYT5TXlkW0GQR1XS
MZ7-melMYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NULFRZNTUUN3ME2wMlA1OzNizszNMWPTRW5ITVJ?
BxPC-3NGDQbnFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MUfJR|UxRTBwMESzOFEh|ryPMUHTRW5ITVJ?
HT-29NUG2bII4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NF\QdlFKSzVyPUCuNFQ{PTdizszNMl3uV2FPT0WU
SK-MEL-30MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NGKyPJZKSzVyPUCuNFQ{PjJizszNNFntWJRUSU6JRWK=
CAL-33M2jWcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MYXJR|UxRTBwMESzO|Uh|ryPNXPsN|FUW0GQR1XS
COLO-680NMXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MlLwTWM2OD1yLkC0OFA4KM7:TR?=MYHTRW5ITVJ?
NH-12NH3TbXVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NUDKU5pmUUN3ME2wMlA1PDRizszNNWDYdZByW0GQR1XS
HCC1937NYTVOJEzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MVLJR|UxRTBwMES0OVYh|ryPMnXHV2FPT0WU
IMR-5NFLNU49Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MY\JR|UxRTBwMES0PUDPxE1?MkOxV2FPT0WU
MC-CARNEja[nRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NFLIbXdKSzVyPUCuNFQ2PjlizszNMknpV2FPT0WU
NCI-H747NFfjPZNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NHXvfpBKSzVyPUCuNFQ2PyEQvF2=NXPWNGlxW0GQR1XS
NCI-H1792MmmxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MoniTWM2OD1yLkC0OVgyKM7:TR?=NUHKc|ZVW0GQR1XS
SW13MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MmnsTWM2OD1yLkC0OVkh|ryPM13RR3NCVkeHUh?=
MLMAMlfXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M36zWmlEPTB;MD6wOFYxQSEQvF2=NHjVRZdUSU6JRWK=
U251M3XSc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7MmPoTWM2OD1yLkC0O|Y{KM7:TR?=NF\sOplUSU6JRWK=
U031M{DGTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MV7JR|UxRTBwMES3O|Eh|ryPM3PEdXNCVkeHUh?=
ME-180MmHjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MXvJR|UxRTBwMES3PFIh|ryPMWnTRW5ITVJ?
SK-MEL-3NUn3fZBCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NHjyN|hKSzVyPUCuNFQ5ODJizszNNWi3eoNtW0GQR1XS
MOLT-4MnjSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M133cWlEPTB;MD6wOFgxOyEQvF2=MUHTRW5ITVJ?
PF-382Mn6zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?Mo\JTWM2OD1yLkC0PFI3KM7:TR?=Ml7nV2FPT0WU
NUGC-3MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M{POVWlEPTB;MD6wOFgzPyEQvF2=M1WxU3NCVkeHUh?=
NCI-H1417Mn\GS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NIDHbo5KSzVyPUCuNFQ5QSEQvF2=MWjTRW5ITVJ?
COLO-205MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NUDx[Vg3UUN3ME2wMlA1QTF7IN88US=>M3HEbHNCVkeHUh?=
TE-441-TNFjjeJdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MUfJR|UxRTBwMES5N{DPxE1?Mo\mV2FPT0WU
MKN1M3fuZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NYTDU2x[UUN3ME2wMlA1QTNizszNMlTUV2FPT0WU
UM-UC-3NGDJNlNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MYXJR|UxRTBwMES5OUDPxE1?MmfpV2FPT0WU
SF126NIDKephIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NE\uVVVKSzVyPUCuNFUxOSEQvF2=M3LUdHNCVkeHUh?=
LB1047-RCCMnjhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M2\ydGlEPTB;MD6wOVA{OSEQvF2=NH7uZ5RUSU6JRWK=
A253NVqxdZllT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NHXXdFFKSzVyPUCuNFUxPTJizszNM4TMZnNCVkeHUh?=
NCI-H1963MoS5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NWjpSnhYUUN3ME2wMlA2OTd4IN88US=>NXnkTpNMW0GQR1XS
VM-CUB-1MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MlvkTWM2OD1yLkC1N|EyKM7:TR?=MXnTRW5ITVJ?
T-24NVz0N5Z3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M4\rSmlEPTB;MD6wOVM5PCEQvF2=M4OxO3NCVkeHUh?=
K-562NWHUWY9GT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MVjJR|UxRTBwMEWzPFch|ryPNFnxfXJUSU6JRWK=
ARH-77M4TISWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MY\JR|UxRTBwMEWzPVUh|ryPMoDoV2FPT0WU
CA46MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MkPPTWM2OD1yLkC1OFMh|ryPMlfqV2FPT0WU
HCC70NIHGPY9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NHGzSGZKSzVyPUCuNFU1PTJizszNM4LpV3NCVkeHUh?=
ST486NFLNeINIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M3\mPWlEPTB;MD6wOVUzPSEQvF2=Mk[2V2FPT0WU
COLO-741MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NIftUZpKSzVyPUCuNFU2OzFizszNNWLPNYl4W0GQR1XS
SK-PN-DWMXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M3rHOmlEPTB;MD6wOVU5QCEQvF2=Ml;kV2FPT0WU
BL-41NX3ITVAyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MYfJR|UxRTBwMEW1PVYh|ryPNFXKPJFUSU6JRWK=
D-263MGNYmxWW1LT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NEnVbItKSzVyPUCuNFU3QDNizszNNI\xTnZUSU6JRWK=
KE-37NIj2fmdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NGnD[GFKSzVyPUCuNFU3QDNizszNNHf2UHRUSU6JRWK=
LU-134-ANUPuTIU1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MmnTTWM2OD1yLkC1O|E2KM7:TR?=Mnq0V2FPT0WU
HCC2157M1[4[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MYHJR|UxRTBwMEW3N|Mh|ryPMVnTRW5ITVJ?
GAKM4rNeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MmjBTWM2OD1yLkC1O|M1KM7:TR?=NUe2eZF2W0GQR1XS
IST-SL2M1HITGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MV;JR|UxRTBwMEW3OFMh|ryPNYCzZ3hYW0GQR1XS
KMOE-2NV75XIs6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NXjU[5RwUUN3ME2wMlA2PzR7IN88US=>MnzTV2FPT0WU
SW1573NFHsSpRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MWPJR|UxRTBwMEW4NFIh|ryPMlX0V2FPT0WU
SCC-9MlfmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MWXJR|UxRTBwMEW4O{DPxE1?NH3DO2FUSU6JRWK=
MDA-MB-361MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NF3RTJpKSzVyPUCuNFU5PzJizszNMlv4V2FPT0WU
BHT-101NIHjUGZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NW\3OXN1UUN3ME2wMlA2QDd4IN88US=>M1nrbnNCVkeHUh?=
NCI-H1770M1[0fGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MonUTWM2OD1yLkC1PFc6KM7:TR?=M1OybXNCVkeHUh?=
UACC-893M4rFTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MnfVTWM2OD1yLkC1PFk3KM7:TR?=Mlf5V2FPT0WU
NCI-H226NWDNelRXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MX7JR|UxRTBwMEW5PFgh|ryPNUDSfXVWW0GQR1XS
HLEMnu1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M{LNNWlEPTB;MD6wOlA5OiEQvF2=MnLGV2FPT0WU
NCI-H1703NXfkXFY3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MU\JR|UxRTBwME[xO|gh|ryPMmmyV2FPT0WU
KURAMOCHINXG0ZmszT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M2r3VGlEPTB;MD6wOlE5QSEQvF2=NXiyWlg1W0GQR1XS
RH-1MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NXPKfZI5UUN3ME2wMlA3OjNizszNNIr6U3ZUSU6JRWK=
DSH1NFX2bIRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NYnnVYlUUUN3ME2wMlA3OjdizszNM1vWe3NCVkeHUh?=
CAMA-1M1Hnd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7NYTGSWFYUUN3ME2wMlA3OzB|IN88US=>M{HNWnNCVkeHUh?=
NCI-H1437NUXKVmh[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NUjtZWFSUUN3ME2wMlA3OzJ6IN88US=>NEHCRpFUSU6JRWK=
HuP-T4NFPqTVRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NX3pbY9DUUN3ME2wMlA3PTh4IN88US=>MYnTRW5ITVJ?
HCT-15NVqxcWVDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NELrfFFKSzVyPUCuNFY2QTdizszNMmiwV2FPT0WU
NCCITMVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NXm0Z4h4UUN3ME2wMlA3PjB2IN88US=>NF;6cppUSU6JRWK=
BOKUMnW3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MVTJR|UxRTBwME[2O|Qh|ryPNGnCTYxUSU6JRWK=
FADUMlflS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NEnLNZBKSzVyPUCuNFY4PDVizszNNV61XYZQW0GQR1XS
SUP-T1MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MYDJR|UxRTBwME[3OkDPxE1?NIjxZZBUSU6JRWK=
L-363M{Hvd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7NVLJV2VyUUN3ME2wMlA3QTBzIN88US=>NXjae|dCW0GQR1XS
KNS-81-FDMoDHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M2fRZWlEPTB;MD6wOlkyQCEQvF2=NGXZV5FUSU6JRWK=
SU-DHL-1NVHoeYtNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MkXSTWM2OD1yLkC2PVIh|ryPNELIcopUSU6JRWK=
HuH-7M2PEd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7NF\CbmVKSzVyPUCuNFcxOzVizszNNITsRpdUSU6JRWK=
BT-474NXPMfmRlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MWHJR|UxRTBwMEewOlEh|ryPMX;TRW5ITVJ?
CAPAN-1MkPXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MWXJR|UxRTBwMEexOFMh|ryPNH7UVldUSU6JRWK=
HEC-1NWT6WmIxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MYHJR|UxRTBwMEexOlEh|ryPMYfTRW5ITVJ?
NOMO-1M{jzR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7NHG1cZNKSzVyPUCuNFcyPzJizszNNYK0RZN5W0GQR1XS
KM-H2NX:4TIlOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NH3zV5ZKSzVyPUCuNFczPDFizszNNVq5d3I4W0GQR1XS
EB2NG\rVVlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M2Dw[2lEPTB;MD6wO|I5PSEQvF2=MmnXV2FPT0WU
LU-99AMUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M2DFWGlEPTB;MD6wO|I5PyEQvF2=MVXTRW5ITVJ?
WSU-NHLNVXnS3BnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NV3jNGNWUUN3ME2wMlA4OzJ7IN88US=>MULTRW5ITVJ?
Calu-1MmCxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NEXNZoFKSzVyPUCuNFc{OzJizszNMoe2V2FPT0WU
U-698-MNVy5R3dmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NGjhemZKSzVyPUCuNFc{QDJizszNNHv6NFlUSU6JRWK=
T98GM1[xemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MmfvTWM2OD1yLkC3OFIyKM7:TR?=NU\NTYdVW0GQR1XS
GI-ME-NNYTKRnp1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NGjyU5JKSzVyPUCuNFc1OjZizszNNWrkcXU{W0GQR1XS
LS-513MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?Mly1TWM2OD1yLkC3OFU3KM7:TR?=NULlcHRbW0GQR1XS
UACC-257Mli2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MlXyTWM2OD1yLkC3OVA2KM7:TR?=NUnqWo1TW0GQR1XS
DK-MGM4LDOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M3vseGlEPTB;MD6wO|UzPiEQvF2=MnHuV2FPT0WU
EW-11MnXhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NFXONJZKSzVyPUCuNFc2OzVizszNMoHlV2FPT0WU
CHP-126M1;KPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MUPJR|UxRTBwMEe1OlUh|ryPM{\pbnNCVkeHUh?=
Saos-2NYTOW2MyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NWjHUIs2UUN3ME2wMlA4PTl5IN88US=>NHTycHZUSU6JRWK=
Ramos-2G6-4C10NHzNOpRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M1XwRWlEPTB;MD6wO|Y1QCEQvF2=NWfOZlFCW0GQR1XS
L-428NEnzOWNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MojJTWM2OD1yLkC3O|A1KM7:TR?=MUDTRW5ITVJ?
HOP-92MmjyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MkPRTWM2OD1yLkC3O|EyKM7:TR?=NV\ue29lW0GQR1XS
PANC-08-13NW\rO4R3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NF3jWZFKSzVyPUCuNFc4OTZizszNM3vzUnNCVkeHUh?=
TURMnq0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MorpTWM2OD1yLkC3O|M{KM7:TR?=MWTTRW5ITVJ?
DMS-153M1Plemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M4T4NWlEPTB;MD6wO|c{PSEQvF2=NIXUNWJUSU6JRWK=
NCI-N87MnnpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M{nmbWlEPTB;MD6wO|c6QSEQvF2=MWXTRW5ITVJ?
ESS-1NHXrc|NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MYDJR|UxRTBwMEe4Olgh|ryPNGDxRXNUSU6JRWK=
CP66-MELMn;2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MknGTWM2OD1yLkC3PFg4KM7:TR?=NF;rOotUSU6JRWK=
NCI-SNU-1NXnDeVN1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M1jGPGlEPTB;MD6wO|g5QCEQvF2=M{D1cXNCVkeHUh?=
Calu-6NX;rXWJ1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NXXodmlKUUN3ME2wMlA4QTZ3IN88US=>M{XDVXNCVkeHUh?=
COLO-668M3fHXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M3z5cGlEPTB;MD6wO|k5PCEQvF2=MVXTRW5ITVJ?
SK-CO-1MkHhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NVS5UWd4UUN3ME2wMlA4QTl{IN88US=>Mn61V2FPT0WU
NCI-H2347NWW0VIxxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NHfYV3VKSzVyPUCuNFgxOjhizszNMU\TRW5ITVJ?
CAL-27M4q2Umdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MmnGTWM2OD1yLkC4NVU3KM7:TR?=NEHvRYlUSU6JRWK=
COLO-684NEfPbIlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NITMUVVKSzVyPUCuNFgyPThizszNMWnTRW5ITVJ?
LNCaP-Clone-FGCNXztbHM2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M1nibWlEPTB;MD6wPFE3PSEQvF2=NHL2eI9USU6JRWK=
NCI-H1304M4DIWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M1HEbGlEPTB;MD6wPFI4OSEQvF2=NWfPPXRJW0GQR1XS
KP-N-YSNX7DbnNXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NFzCN5dKSzVyPUCuNFg{PDVizszNMUXTRW5ITVJ?
CP50-MEL-BNXjuSXJ[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NVj5NmVuUUN3ME2wMlA5OzZ6IN88US=>MX7TRW5ITVJ?
LAN-6NXfCfIhPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MYrJR|UxRTBwMEi0PVgh|ryPM1POUnNCVkeHUh?=
ABC-1M2rVN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7Mn:xTWM2OD1yLkC4O|U6KM7:TR?=MljDV2FPT0WU
ES3NXfucY9YT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NVHRNo1yUUN3ME2wMlA5PzZ|IN88US=>M16wTnNCVkeHUh?=
COLO-792M4LyPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MYnJR|UxRTBwMEi4OVUh|ryPNInpcJdUSU6JRWK=
J-RT3-T3-5MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NXX0eVJQUUN3ME2wMlA5QTZ6IN88US=>NVfR[m0xW0GQR1XS
EFO-21M2rremdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MVvJR|UxRTBwMEi5PVEh|ryPM3yzTXNCVkeHUh?=
MDA-MB-231MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NF3yV2lKSzVyPUCuNFkxQDJizszNNH;VTZZUSU6JRWK=
SBC-5MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MmO4TWM2OD1yLkC5NVk{KM7:TR?=MXrTRW5ITVJ?
SASM3;zTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7Mn3uTWM2OD1yLkC5NlE2KM7:TR?=NYLtT2ZSW0GQR1XS
SNU-387M1LrTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NU\sWFNKUUN3ME2wMlA6OjF6IN88US=>MkexV2FPT0WU
EVSA-TM{\MZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7Mn\lTWM2OD1yLkC5NlY2KM7:TR?=NVLxfFFlW0GQR1XS
MHH-PREB-1NIfrR5hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M{mzV2lEPTB;MD6wPVMyKM7:TR?=NUnWVWl3W0GQR1XS
KARPAS-45NXy5WGtOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MVHJR|UxRTBwMEmzOFUh|ryPMVHTRW5ITVJ?
SJRH30NIf0flZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NEXOXlFKSzVyPUCuNFk1PDRizszNNGPCPHlUSU6JRWK=
JEG-3MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NHi1eldKSzVyPUCuNFk2ODVizszNMorjV2FPT0WU
NB12NH3wZoRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MYDJR|UxRTBwMEm1NVgh|ryPNXrVcFJ1W0GQR1XS
HCC1419NWTtUmRCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MlWyTWM2OD1yLkC5OVQyKM7:TR?=NXTJZ|FCW0GQR1XS
HCC1599NYm4coxmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=Ml3zTWM2OD1yLkC5OlAyKM7:TR?=NUXBc29EW0GQR1XS
IPC-298MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NHTxN3JKSzVyPUCuNFk3PDRizszNMoPYV2FPT0WU
MPP-89M2fpe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7NUHaSIhZUUN3ME2wMlA6PzJzIN88US=>MWTTRW5ITVJ?
HT-1376MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?Ml7ETWM2OD1yLkC5PFYyKM7:TR?=MX;TRW5ITVJ?
MDA-MB-468M3XBbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M3W4VWlEPTB;MD6wPVk5PSEQvF2=MVfTRW5ITVJ?
HCC2218MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MlnjTWM2OD1yLkC5PVk6KM7:TR?=MoD0V2FPT0WU
LK-2NFHSSGRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NE\ubWxKSzVyPUCuNVAyPzZizszNNHPHXnZUSU6JRWK=
GR-STNGjib29Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NXj4fJp5UUN3ME2wMlExOjFizszNM3PxOnNCVkeHUh?=
PFSK-1M4DBSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NFT5XIdKSzVyPUCuNVAzPjdizszNNYHJ[Wh5W0GQR1XS
NCI-H2052MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NYTab4dGUUN3ME2wMlExPDB5IN88US=>NX7HVoJlW0GQR1XS
A673MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MY\JR|UxRTBwMUC0N|Eh|ryPNILFW4pUSU6JRWK=
EKVXMXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MmmyTWM2OD1yLkGwOFg{KM7:TR?=MmTPV2FPT0WU
23132-87MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NFTiUnNKSzVyPUCuNVA1QDhizszNM2jYeXNCVkeHUh?=
EW-18M3jsdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NFPJWo5KSzVyPUCuNVA3ODRizszNMm\YV2FPT0WU
KU-19-19M2C0RWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MofLTWM2OD1yLkGwPFE4KM7:TR?=MlOzV2FPT0WU
NCI-H441NEXSfnJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M3fncGlEPTB;MD6xNFg6QSEQvF2=MXvTRW5ITVJ?
COLO-824MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NHf4VmZKSzVyPUCuNVExOiEQvF2=NYP6S3ZqW0GQR1XS
HCC1806MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M4rZfGlEPTB;MD6xNVExQCEQvF2=MmDjV2FPT0WU
SK-MM-2NYHhem55T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M4rZPWlEPTB;MD6xNVE1PSEQvF2=M4LmTHNCVkeHUh?=
DELMUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MYLJR|UxRTBwMUGxPVIh|ryPMX7TRW5ITVJ?
NCI-H661NWj4e4I5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NYLuUndUUUN3ME2wMlEyOTl3IN88US=>M3f6cXNCVkeHUh?=
LC4-1NYfEfVd6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NXHlcnpYUUN3ME2wMlEyPDZ4IN88US=>MXTTRW5ITVJ?
BENM2\pWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MULJR|UxRTBwMUG2NFch|ryPMYHTRW5ITVJ?
RPMI-8226MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?Mn;3TWM2OD1yLkGxO|E6KM7:TR?=MlrOV2FPT0WU
AU565MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NGWxfZhKSzVyPUCuNVE5OzFizszNM{DOb3NCVkeHUh?=
CAS-1NIrnWHNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MX\JR|UxRTBwMUG5OlQh|ryPMkW2V2FPT0WU
UACC-62NIexR5VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NFzXUZNKSzVyPUCuNVIyOiEQvF2=MYrTRW5ITVJ?
C-4-IIM2TYV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7M1nGZ2lEPTB;MD6xNlE4KM7:TR?=NH:zPHpUSU6JRWK=
DMS-53MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M2HVU2lEPTB;MD6xNlI4PiEQvF2=NX:ye2hNW0GQR1XS
SK-MEL-2NWTh[3JoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MnzGTWM2OD1yLkGyOFYh|ryPNVrvfpZXW0GQR1XS
S-117NUf5N3hyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MVTJR|UxRTBwMUK2O|Qh|ryPNYW1bVRVW0GQR1XS
ChaGo-K-1NIPzXJRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NVr5ZXV6UUN3ME2wMlEzPjl7IN88US=>M1rHRnNCVkeHUh?=
KMS-12-PEM4PUeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NEPnc|VKSzVyPUCuNVI5PjlizszNMYLTRW5ITVJ?
PC-3NHHSd45Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NVz6eWpIUUN3ME2wMlE{OTd5IN88US=>M1u5NHNCVkeHUh?=
RERF-LC-MSNH\NXINIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NIOzUXNKSzVyPUCuNVM1OyEQvF2=NULIZY1[W0GQR1XS
GMS-10NHS2PJdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M1Sx[2lEPTB;MD6xN|Q1PCEQvF2=M4C2RnNCVkeHUh?=
CTB-1Mn\LS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NU\mc2JzUUN3ME2wMlE{PDZ7IN88US=>M2HJWnNCVkeHUh?=
SCC-25M2HHdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NF;HZ4lKSzVyPUCuNVM2QDhizszNMmLZV2FPT0WU
NCI-H1755Mn3HS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MkSyTWM2OD1yLkGzPFI4KM7:TR?=NH3hfZVUSU6JRWK=
D-542MGMnL2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NFLnSHNKSzVyPUCuNVM6PjVizszNM1:5SHNCVkeHUh?=
KARPAS-422NGjoOGVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NIjJUXdKSzVyPUCuNVQxOzdizszNMkW2V2FPT0WU
OVCAR-3MmHJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NU\QT|Z1UUN3ME2wMlE1ODd6IN88US=>MonEV2FPT0WU
NCI-H1092NHWwe3JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MmqzTWM2OD1yLkG0NVAyKM7:TR?=M3X4c3NCVkeHUh?=
HHNVHodohPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NV7RO45LUUN3ME2wMlE1OjBzIN88US=>MkPhV2FPT0WU
NB1NGf3doJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MoPKTWM2OD1yLkG0OFI3KM7:TR?=MY\TRW5ITVJ?
HD-MY-ZNHXGfnJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MYLJR|UxRTBwMUS0Nlkh|ryPNUfVVJJ{W0GQR1XS
SHP-77Mlv2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MmHKTWM2OD1yLkG0OFczKM7:TR?=MlvrV2FPT0WU
U-266MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NIfrfpJKSzVyPUCuNVQ1QCEQvF2=M{f0SnNCVkeHUh?=
GI-1NEnPVJBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NI\kRYpKSzVyPUCuNVQ4PzJizszNNWH4[VlSW0GQR1XS
NCI-H1522NWnkbJA4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MVjJR|UxRTBwMUS3PFch|ryPMlPYV2FPT0WU
647-VMWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M1WwTWlEPTB;MD6xOFk1OiEQvF2=Ml2wV2FPT0WU
HCT-116M4\HWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M2i4ZWlEPTB;MD6xOVE3QSEQvF2=M4rQUXNCVkeHUh?=
NCI-H2081M2PXZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MmjnTWM2OD1yLkG1NlE5KM7:TR?=NInWUFJUSU6JRWK=
THP-1M4jORWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MX3JR|UxRTBwMUWzN|Mh|ryPM3n3XHNCVkeHUh?=
LU-165MlzVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NUjHO4h2UUN3ME2wMlE2PDF|IN88US=>MWrTRW5ITVJ?
RCM-1NWfYPJlmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NHX5T4RKSzVyPUCuNVU3QCEQvF2=M3LofHNCVkeHUh?=
COR-L279MoDRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MVzJR|UxRTBwMUW4N|Yh|ryPMWnTRW5ITVJ?
SK-NEP-1NXThRYQzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M2PxN2lEPTB;MD6xOVg6QSEQvF2=MnrRV2FPT0WU
KLENIXRSopIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NUDofJY6UUN3ME2wMlE3OTZ7IN88US=>NX\KXHhTW0GQR1XS
NCI-H2170MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NIX0[4xKSzVyPUCuNVY{ODRizszNM4nCenNCVkeHUh?=
TGWMUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NInSVG1KSzVyPUCuNVY1PzFizszNMmPKV2FPT0WU
CAL-72M1Xvfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MUfJR|UxRTBwMU[1PUDPxE1?NF3LN4lUSU6JRWK=
K052MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MnvxTWM2OD1yLkG3NFYyKM7:TR?=NH32NlVUSU6JRWK=
COR-L88NGTwPIJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MU\JR|UxRTBwMUexNVQh|ryPNXX4XWJ2W0GQR1XS
HSC-4MnniS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NXPpSVd3UUN3ME2wMlE4OTZizszNM2XlVHNCVkeHUh?=
GOTOMUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NIPJV5JKSzVyPUCuNVczPDZizszNNFXoenVUSU6JRWK=
MEG-01MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MYXJR|UxRTBwMUeyOVch|ryPM4THXHNCVkeHUh?=
MDA-MB-134-VIM3\hW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7NWTzT5VHUUN3ME2wMlE4OzZ5IN88US=>NWXHWWFEW0GQR1XS
NCI-H596MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MVrJR|UxRTBwMUezPEDPxE1?M{fve3NCVkeHUh?=
EW-3NX\nZ5ZHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=Mo\ITWM2OD1yLkG3OFg3KM7:TR?=NVrvO|IyW0GQR1XS
NCI-H1573NWDaN2E1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MUfJR|UxRTBwMUe2O|gh|ryPNXz2TmVkW0GQR1XS
SKG-IIIaNV3qbVBbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MlP5TWM2OD1yLkG3PFA4KM7:TR?=NVPiNo9KW0GQR1XS
SK-N-DZNX\0cINWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NHvKfo9KSzVyPUCuNVc5QDNizszNMoK3V2FPT0WU
EGI-1Mn3rS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M1fZRWlEPTB;MD6xO|k4KM7:TR?=NGnXUWJUSU6JRWK=
COLO-320-HSRMWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?Ml3iTWM2OD1yLkG4OFk{KM7:TR?=NUC3do1DW0GQR1XS
DOHH-2NHHLRlNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M4e3UGlEPTB;MD6xPFU3QSEQvF2=MWPTRW5ITVJ?
MS-1MmLnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MYPJR|UxRTBwMUi2JO69VQ>?MWfTRW5ITVJ?
NCI-H2171M1Lt[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MlXQTWM2OD1yLkG4OlQ6KM7:TR?=NFzYPHdUSU6JRWK=
NCI-H526NEfiPGpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NGPTemlKSzVyPUCuNVg3QTZizszNMWDTRW5ITVJ?
MDA-MB-415MnLjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M1nmZmlEPTB;MD6xPVc1QCEQvF2=MWHTRW5ITVJ?
ECC4NY\sc|RkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NETOdYpKSzVyPUCuNVk5PjNizszNNV2zS5h6W0GQR1XS
C2BBe1M3;TO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7NFXZRm1KSzVyPUCuNVk5QTNizszNM3LGcXNCVkeHUh?=
TE-11M4L5S2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7NUm3TGw{UUN3ME2wMlE6QTd3IN88US=>M13wPXNCVkeHUh?=
LU-65MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MWnJR|UxRTBwMkCyNVEh|ryPMlLiV2FPT0WU
MKN45MmPSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M3TrcWlEPTB;MD6yNFY1KM7:TR?=MYDTRW5ITVJ?
TGBC1TKBM13UTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NXLZZ2t[UUN3ME2wMlIxQTl5IN88US=>NHexWIRUSU6JRWK=
NCI-H2196MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M3fuUWlEPTB;MD6yNVc1PyEQvF2=NYW0dXdNW0GQR1XS
M14NV;3ZZQ{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MVTJR|UxRTBwMkG4NFMh|ryPMoHIV2FPT0WU
NCI-H1436NHr1NGhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MVrJR|UxRTBwMkG4NlYh|ryPNWTBRm0zW0GQR1XS
EB-3NF7jfGRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NYLRSGxjUUN3ME2wMlIzOzd4IN88US=>MWfTRW5ITVJ?
HTMkPhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MkXTTWM2OD1yLkKyOVY3KM7:TR?=NUTtdJNzW0GQR1XS
A3-KAWM3W4Rmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MlrFTWM2OD1yLkKyO|A5KM7:TR?=M4H0RnNCVkeHUh?=
DBNGf1WoRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NFzHZVlKSzVyPUCuNlI5PjVizszNM4OyVHNCVkeHUh?=
KARPAS-299NFzKe2tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NEfq[5BKSzVyPUCuNlI6QTRizszNNVnnU5RXW0GQR1XS
IM-9MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MXHJR|UxRTBwMkO0O|Yh|ryPM{SzRXNCVkeHUh?=
NCI-H838MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M3jVSWlEPTB;MD6yN|cyPCEQvF2=MnHkV2FPT0WU
NB10MlTlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M1vkWWlEPTB;MD6yN|c{OSEQvF2=NEDofmRUSU6JRWK=
NCI-H2141Mk\sS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M{judGlEPTB;MD6yN|g1OSEQvF2=M1ez[nNCVkeHUh?=
LB647-SCLCM{S5OGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M3eyfGlEPTB;MD6yOFAyPCEQvF2=M3zZPHNCVkeHUh?=
NCI-H23NGfjcJVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MUTJR|UxRTBwMkSwOVkh|ryPM3nYfnNCVkeHUh?=
MN-60MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MULJR|UxRTBwMkSyN|kh|ryPMnX0V2FPT0WU
CAL-148M3HOd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7NWfGZ2RHUUN3ME2wMlI1Ojh{IN88US=>NHjiRZpUSU6JRWK=
EFE-184MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NIn3OZJKSzVyPUCuNlQ2QTdizszNMoT5V2FPT0WU
TE-6NXnEU3NjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=Ml30TWM2OD1yLkK0OlEzKM7:TR?=M3mweHNCVkeHUh?=
SN12CM2Xsbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M1LMTWlEPTB;MD6yOFY6PCEQvF2=NF;lR21USU6JRWK=
CAKI-1NGLn[G1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NVTGV2t[UUN3ME2wMlI2ODh4IN88US=>MmqxV2FPT0WU
MHH-NB-11NWDvbJB3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M3i3d2lEPTB;MD6yOVM2KM7:TR?=MkLOV2FPT0WU
DOKM4noZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NEHZTWhKSzVyPUCuNlU6OyEQvF2=MoXmV2FPT0WU
RajiM3W2[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7Ml;ITWM2OD1yLkK2OlA{KM7:TR?=M1\QOnNCVkeHUh?=
OAW-28MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MlfnTWM2OD1yLkK2Olc4KM7:TR?=M{TO[XNCVkeHUh?=
P30-OHKMnfYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NXX3eGxwUUN3ME2wMlI3QTB3IN88US=>M{HIRXNCVkeHUh?=
NCI-H69NIiyNGtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M3L2UmlEPTB;MD6yO|IxOSEQvF2=M4O5PHNCVkeHUh?=
SK-N-ASM2\MT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7MV3JR|UxRTBwMkeyNkDPxE1?MVLTRW5ITVJ?
BE-13MlruS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MWrJR|UxRTBwMkeyOFkh|ryPMX3TRW5ITVJ?
NCI-H1618M{\VOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MkPGTWM2OD1yLkK3OVEh|ryPNIO3[nRUSU6JRWK=
NCI-SNU-5Mnv6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MkHqTWM2OD1yLkK3OlE{KM7:TR?=NUHTb2FpW0GQR1XS
NCI-H1694M1jWc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7M{\kOmlEPTB;MD6yO|c{OyEQvF2=MV3TRW5ITVJ?
RLM{H3bWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MWnJR|UxRTBwMkixO|Qh|ryPNGHvcWJUSU6JRWK=
SW684MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NVzlNXc2UUN3ME2wMlI5Ozh|IN88US=>MUnTRW5ITVJ?
EW-24NV7QXZlKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NVfCc3lWUUN3ME2wMlI5QDFizszNMUPTRW5ITVJ?
NCI-H510AMUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NX[4dWxVUUN3ME2wMlI6OzB2IN88US=>MWPTRW5ITVJ?
Mo-TNG\mcZZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NES1SHRKSzVyPUCuNlk{OzFizszNM3nKfXNCVkeHUh?=
LB373-MEL-DNVXmO3V1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MW\JR|UxRTBwMkm0N|Eh|ryPNVHIVHN2W0GQR1XS
NCI-H28M1\Ub2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7M4HGZmlEPTB;MD6yPVg{PyEQvF2=M3LEeXNCVkeHUh?=
NCI-H446MkDPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MnvGTWM2OD1yLkK5PVIyKM7:TR?=NFLzZWZUSU6JRWK=
L-540NEjnV5lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NF3OW4NKSzVyPUCuN|AxQDlizszNNFLJSo9USU6JRWK=
MKN7MmeyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MUDJR|UxRTBwM{C2N|kh|ryPMVjTRW5ITVJ?
OPM-2NEH4PZdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NWTvZZlYUUN3ME2wMlMyODZ2IN88US=>NXfES3UzW0GQR1XS
BT-20Mnf1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NIPXdZBKSzVyPUCuN|ExQTlizszNMn3JV2FPT0WU
KP-N-YNNV3nWpM2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NVf4[mtYUUN3ME2wMlMyOTF6IN88US=>MoLqV2FPT0WU
MDA-MB-175-VIIM1zXcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MnLFTWM2OD1yLkOyN|Q5KM7:TR?=MXvTRW5ITVJ?
EFM-19MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M2HIdmlEPTB;MD6zN|E{OiEQvF2=NVvBUo8zW0GQR1XS
COLO-678MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M1y3WGlEPTB;MD6zN|M5QSEQvF2=M130[XNCVkeHUh?=
COLO-829M1vI[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MXrJR|UxRTBwM{S0OVIh|ryPMYDTRW5ITVJ?
A704MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MnvPTWM2OD1yLkO0PVI{KM7:TR?=NWTEdFVsW0GQR1XS
NCI-H719NXnUOlZRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NF7FUXhKSzVyPUCuN|UyOjRizszNM3zPOXNCVkeHUh?=
MFE-280MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MkXDTWM2OD1yLkO1O|E2KM7:TR?=MlXXV2FPT0WU
DMS-114M2ey[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NHLhWW1KSzVyPUCuN|YyOiEQvF2=NEDRdHRUSU6JRWK=
RMG-IMofwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MmjkTWM2OD1yLkO2OlkyKM7:TR?=M2nLRXNCVkeHUh?=
SK-N-FIMUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MYfJR|UxRTBwM{e2N|ch|ryPM3TueXNCVkeHUh?=
LB2518-MELMUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M{T5O2lEPTB;MD60NFg4OiEQvF2=M3:wSXNCVkeHUh?=
IST-MES1NHrU[lNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MVXJR|UxRTBwNEGxJO69VQ>?MYrTRW5ITVJ?
HPAF-IINUnFUZRGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MWnJR|UxRTBwNEGxNVch|ryPMknMV2FPT0WU
NCI-H1882MlW2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NXS1W25iUUN3ME2wMlQyPzh2IN88US=>MmP6V2FPT0WU
JVM-2MonMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NFzjXppKSzVyPUCuOFQ1ODFizszNMWLTRW5ITVJ?
T47DM2DpUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NYmze5BtUUN3ME2wMlQ1PTJ6IN88US=>NVv6c40zW0GQR1XS
MHH-CALL-2MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NHP6O5hKSzVyPUCuOFQ5OyEQvF2=NHXVdmhUSU6JRWK=
NCI-H716MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MX;JR|UxRTBwNES4OFgh|ryPNFPDWnVUSU6JRWK=
NEC8M4\6Umdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NILscZZKSzVyPUCuOFUyPDVizszNM3PjTnNCVkeHUh?=
UACC-812M2nZ[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NUD5cGI2UUN3ME2wMlQ3Pzd4IN88US=>M{P4VHNCVkeHUh?=
D-502MGMUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NGW0TlZKSzVyPUCuOFgxOyEQvF2=NXrEbY1lW0GQR1XS
CaR-1NILzT2tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MkC3TWM2OD1yLkWwN|Y4KM7:TR?=MmLsV2FPT0WU
LU-139M1u5bWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MlvDTWM2OD1yLkWxOFU4KM7:TR?=M{\J[nNCVkeHUh?=
RPMI-8402MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NX70[XhsUUN3ME2wMlUzOjB5IN88US=>M2r0[3NCVkeHUh?=
SW1088Mn7wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MkPtTWM2OD1yLkWzPFY6KM7:TR?=NFvIbJVUSU6JRWK=
JVM-3M1PMOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7Mn7qTWM2OD1yLkW0NVE4KM7:TR?=NWTiSW1PW0GQR1XS
YAPCMnvUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NXTo[Xp7UUN3ME2wMlU2OjFzIN88US=>MYrTRW5ITVJ?
KG-1MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?Mn3qTWM2OD1yLkW1PVg1KM7:TR?=NWGyVXJxW0GQR1XS
C32NFnBNXBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MWXJR|UxRTBwNUezNVMh|ryPNH7V[Y9USU6JRWK=
IST-SL1MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NEjQc3JKSzVyPUCuOlA1OzVizszNNF\DXHdUSU6JRWK=
NCI-H2126NU\nVIZWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MnvyTWM2OD1yLk[zNVUzKM7:TR?=NGO5Z2lUSU6JRWK=
HCC1954Mlv5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NFXPR|JKSzVyPUCuOlQ4OjZizszNM4XPOnNCVkeHUh?=
WM-115MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MYXJR|UxRTBwNkWwPVIh|ryPMWjTRW5ITVJ?
NB6NY\hSIlNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MlfITWM2OD1yLk[3N|M2KM7:TR?=MVLTRW5ITVJ?
TYK-nuM4TwSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7Mo[0TWM2OD1yLk[3PVUzKM7:TR?=M336U3NCVkeHUh?=
KY821MnX1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NXvHUlNzUUN3ME2wMlcxOjJ7IN88US=>MVXTRW5ITVJ?
SIMAMY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MV3JR|UxRTBwN{G3NVkh|ryPNGjpdWZUSU6JRWK=
RCC10RGBMXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NGfjdWtKSzVyPUCuO|E6OThizszNM3;KOnNCVkeHUh?=
LN-405NGn5V3JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MXTJR|UxRTBwN{SzOkDPxE1?M{HVdHNCVkeHUh?=
NCI-H1155NYLUXZZpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MUPJR|UxRTBwN{S4Olgh|ryPMmXuV2FPT0WU
SCLC-21HMnX3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NGnrR5VKSzVyPUCuO|Y6ODNizszNNEi0Z4tUSU6JRWK=
DMS-79M{Xmemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NHTqV2FKSzVyPUCuO|c5PDVizszNMXjTRW5ITVJ?
EC-GI-10MorPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NIS3enJKSzVyPUCuO|c6PzVizszNMnP6V2FPT0WU
KNS-42MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NIfhSpJKSzVyPUCuO|g5OzFizszNM4fWU3NCVkeHUh?=
SNU-475NH;vNW1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MXnJR|UxRTBwN{myNFIh|ryPMor3V2FPT0WU
SF539NEHqTmNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MmHCTWM2OD1yLke5PVI2KM7:TR?=M3LLUnNCVkeHUh?=
SW1417NV2xRYhxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MXjJR|UxRTBwOEGzN|kh|ryPMlHhV2FPT0WU
ATN-1MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NETGPWNKSzVyPUCuPFUyOTVizszNMYDTRW5ITVJ?
PLC-PRF-5NUHMXG5mT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NIX2TY5KSzVyPUCuPFg1PzVizszNMn\tV2FPT0WU
HT-3NXTiRYVrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MXfJR|UxRTBwOEm0NkDPxE1?MYXTRW5ITVJ?
MDA-MB-453M{fFeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7Mme1TWM2OD1yLkmwN|A1KM7:TR?=MYLTRW5ITVJ?
HAL-01MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MXvJR|UxRTBwOUmzO|kh|ryPMWXTRW5ITVJ?
NCI-H1993M{fqdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M13u[mlEPTB;MT6wOFY2PyEQvF2=MonJV2FPT0WU
NCI-H2227MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MV;JR|UxRTFwMES5PFEh|ryPNWS5cYcyW0GQR1XS
LP-1NHXJe5dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NYTQUG1[UUN3ME2xMlA3QTNizszNNHHNfm9USU6JRWK=
P31-FUJMmrwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MkHVTWM2OD1zLkGwO|Y3KM7:TR?=M3LhN3NCVkeHUh?=
NCI-H64MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NVPad3NYUUN3ME2xMlE2PDJizszNNUjNNGxjW0GQR1XS
SW1463NIK5ZW5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NE\kOHZKSzVyPUGuNVg{PDlizszNNV\FRlNwW0GQR1XS
SK-MEL-1M3XteGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NIL6U5RKSzVyPUGuNlA2QTVizszNMlnLV2FPT0WU
TALL-1MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?Moi2TWM2OD1zLkK1NVY2KM7:TR?=M3SzRnNCVkeHUh?=
RO82-W-1NHzC[4lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MWDJR|UxRTFwM{OzN|kh|ryPNH7lR4JUSU6JRWK=
NCI-H1581MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NXP3NnNVUUN3ME2xMlM2Pjh5IN88US=>NEW1fGhUSU6JRWK=
NCI-H748NX;EcZRXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NYjwVHhLUUN3ME2xMlM2PzN6IN88US=>MlX6V2FPT0WU
HCC1187MmrBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NWrXOnNpUUN3ME2xMlU2PTJ{IN88US=>M2X0cXNCVkeHUh?=
EoL-1-cellNHz6dmJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M1rsbGlEPTB;MT61PFg5QSEQvF2=NHW0NZNUSU6JRWK=
HuO-3N1M2SwXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NF2ybIZKSzVyPUGuPFM1OTJizszNNWf5THFOW0GQR1XS
NCI-H1793NV;4V5piT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M{PadWlEPTB;MT64O|U6OyEQvF2=Mk\RV2FPT0WU
Caov-3MoXrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NVTLdJF7UUN3ME2yMlAxPjJ3IN88US=>MXvTRW5ITVJ?
JARNXHvR5ZjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NEDofVJKSzVyPUKuNFc6OiEQvF2=NWjITpd1W0GQR1XS
SK-MEL-28M{n3d2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7M4T3cmlEPTB;Mj6xPFA6QCEQvF2=NYfVPYY5W0GQR1XS
EM-2NFTwT4dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M{TYTGlEPTB;Mj6yNFI6OyEQvF2=NFPLNmlUSU6JRWK=
MewoNIjnbFBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NGjsRopKSzVyPUKuNlIzPjVizszNNFr6VolUSU6JRWK=
NCI-H720MnfzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MUnJR|UxRTJwMk[1PFUh|ryPNXnCZlVOW0GQR1XS
CAL-54NUfwdZl1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NX\4SHFyUUN3ME2yMlI3Pzl3IN88US=>NUHRfGRLW0GQR1XS
MC116MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MWfJR|UxRTJwM{[zPVch|ryPMVPTRW5ITVJ?
DG-75NUjud5ZZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MVPJR|UxRTJwNEi1O|Yh|ryPNF;K[3RUSU6JRWK=
HCC1143NFTzUlJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M3nMRWlEPTB;Mj61NFY2QCEQvF2=MVXTRW5ITVJ?
FTC-133NID0bZFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M2nlO2lEPTB;Mj61N|Y5QSEQvF2=MYTTRW5ITVJ?
AsPC-1MnW5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NHjnV5hKSzVyPUKuOVM6OjlizszNMmHLV2FPT0WU
NCI-H889NV7sd2tWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MUXJR|UxRTJwNU[3NFYh|ryPMVHTRW5ITVJ?
HT55Mmm5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MojJTWM2OD1{Lk[yNFE6KM7:TR?=M4DGW3NCVkeHUh?=
UMC-11M3WyRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NGL3e3hKSzVyPUKuO|g4OTVizszNMWHTRW5ITVJ?
P12-ICHIKAWANWHIPZNyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NWj2VWN3UUN3ME2yMlgzODR4IN88US=>M17ITnNCVkeHUh?=
HCC1395NWXScJRzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NHrUfoVKSzVyPUKuPVg3ODJizszNM3;2bHNCVkeHUh?=
D-283MEDNG\ETGlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M1P3VWlEPTB;Mz6xPFk{PyEQvF2=MmS1V2FPT0WU
COLO-800MkPSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MnrSTWM2OD1|LkOzPFk4KM7:TR?=NG[3WYdUSU6JRWK=
MFM-223MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NUPNWHgzUUN3ME2zMlM3ODl5IN88US=>NIXLbJRUSU6JRWK=
TE-5NGK3XFBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MmnnTWM2OD12LkW2NVQ4KM7:TR?=NIrIOXdUSU6JRWK=
NCI-H209M2C4UWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NUP6UlRmUUN3ME20Mlc5PTd{IN88US=>M4PVWHNCVkeHUh?=
SiHaNWnQUFBVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MWHJR|UxRTRwOUWyNFMh|ryPMWXTRW5ITVJ?
NCI-H1395M1vWcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NHj0V4RKSzVyPUWuNVA3OzNizszNNIjV[VdUSU6JRWK=
A498NYPVSJFxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NXn4RlhPUUN3ME21MlIyOjVzIN88US=>M3WyN3NCVkeHUh?=
ES5NEPHTY1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M3nWN2lEPTB;NT62NVE4QCEQvF2=NH3VUG9USU6JRWK=
MDA-MB-157NFfkcmVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MonFTWM2OD13Lk[2OFQ{KM7:TR?=MlPoV2FPT0WU
NCI-H1623NETkUJNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NXvv[oU5UUN3ME21Mlg{PTV4IN88US=>NWmweFZpW0GQR1XS
RPMI-8866MoH6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NUe2THZxUUN3ME21Mlg1Pzl{IN88US=>NEDKXJBUSU6JRWK=
LC-1FMmLvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M3Tm[GlEPTB;Nj6wPVI6OSEQvF2=NUjF[5VKW0GQR1XS
TCCSUPMoPTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M1zSbGlEPTB;Nj62NFM1QSEQvF2=NXG2RoVEW0GQR1XS
TTMlvES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NY\qO3NsUUN3ME24MlM{ODB7IN88US=>NXTYWGdiW0GQR1XS
NCI-H1838NVWwfWl4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NX3a[pNQUUN3ME24MlUyPzNzIN88US=>NXfSeok6W0GQR1XS
NCI-H322MM2rxfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MnzzTWM2OD17LkG2NlgyKM7:TR?=MXfTRW5ITVJ?
NCI-H187NYjTWZlrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MWLJR|UxRTlwNUG4N|Uh|ryPMVPTRW5ITVJ?
SBC-1NFLPNVBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MnX2TWM2OD17LkmzOlU3KM7:TR?=NHjlNZhUSU6JRWK=
SCC-3NVTPcYZ2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M4rKPGlEPTB;MUCuOVY4QSEQvF2=MYPTRW5ITVJ?
SW948M2njbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MmTDTWM2OD1zMD63OVEyKM7:TR?=MUfTRW5ITVJ?
CPC-NMnzjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NFHINW9KSzVyPUGxMlAxPyEQvF2=NEj1TmZUSU6JRWK=
TGBC24TKBNIjBSldIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NF7RcZlKSzVyPUGzMlUzQSEQvF2=NV\se45kW0GQR1XS
NCI-H2452MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NWT1RoRzUUN3ME2xOE44OyEQvF2=NHfkZ4ZUSU6JRWK=
Hs-578-TNUHNb5lDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NGTE[|JKSzVyPUG4MlU4PTlizszNNUi5NoZjW0GQR1XS
DV-90NWmy[HNnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NIrmOmZKSzVyPUG4Mlk6PDVizszNMoXEV2FPT0WU
NCI-H1563NV22fGRwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=Mnv0TWM2OD1zOT63PFg5KM7:TR?=MkTuV2FPT0WU
SW780MljVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MXPJR|UxRTJzLkGzNVgh|ryPNUThSVR1W0GQR1XS
NCI-H345MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NGXlfINKSzVyPUKxMlg4PzlizszNMkLhV2FPT0WU
LB771-HNCNWTkNIdyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MoH0TWM2OD1{Mj60PFE{KM7:TR?=NWrtNnVpW0GQR1XS
RT4NYO0botLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NUfTbGNzUUN3ME2yN{4{Ojh{IN88US=>MYTTRW5ITVJ?
NCI-H82NGnVSmVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NXzmdpd{UUN3ME2yN{42PTJ4IN88US=>Mlu5V2FPT0WU
NCI-H524MnGwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NH\kT5FKSzVyPUK0MlM5OTJizszNNEHYeVdUSU6JRWK=
SNU-C1M{T3R2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7MXrJR|UxRTJ2LkmxNFUh|ryPMYnTRW5ITVJ?
NCI-SNU-16MkfaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NIL0ToNKSzVyPUS4MlMyPDJizszNNE\0[opUSU6JRWK=

... Click to View More Cell Line Experimental Data

In vivo Treatment with NVP-AUY922 causes a robust antitumor response and inhibits p-Akt and VEGF expression in an HSC-2 xenograft model. [2] In BT474, NVP-AUY922 shows complete loss of ERBB2 and substantial depletion of ERα, in addition to reductions in CDK4 and phospho-ERK1/2. [3]
Features

Protocol(Only for Reference)

Kinase Assay: [3]

Kinase assay NVP-AUY922 is dissolved in DMSO at a concentration of 10 mM. NVP-AUY922 is assessed against HSP90α, HSP90β, GRP94, TRAP-1, HSP72, and topoisomerase II. Profiling against a panel of kinases has been carried out and screening against a panel of additional enzymes and receptors is performed at Cerep.

Cell Assay: [1]

Cell lines Human gastric cancer cells NCI-N87
Concentrations 1 μM
Incubation Time 3 days
Method Human gastric cancer cells NCI-N87 (5-7 ×103 in 50 μL/well) are seeded in 96-well plates and incubated at 37 °C for 24 hours, followed by NVP-AUY922 treatment for 1-3 days at 37 °C. After treatment, the cells are assayed by MTT method and analyzed by microplate reader.

Animal Study: [3]

Animal Models Female NCr athymic mice bearing WM266.4 human melanoma xenografts
Formulation In DMSO and diluted in sterile saline/Tween 20
Dosages 50 mg/kg
Administration Administered via i.v. or i.p.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

SpeciesMouseRatRabbitGuinea pigHamsterDog
Weight (kg)0.020.151.80.40.0810
Body Surface Area (m2)0.0070.0250.150.050.020.5
Km factor36128520
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Rat dose (mg/kg) = mouse dose (22.4 mg/kg) ×  mouse Km(3)  = 11.2 mg/kg
rat Km(6)
1

References

[1] Lee KH, et al. Cancer Sci, 2011, 102(7), 1388-1395.

[2] Okui T, et al. Anticancer Res, 2011, 31(4), 1197-1204.

view more

Clinical Trial Information( data from http://clinicaltrials.gov, updated on 2016-07-30)

NCT Number Recruitment Conditions Sponsor
/Collaborators
Start Date Phases
NCT01784640 Active, not recruiting Recurrent Non-small Cell Lung Cancer|Squamous Cell Lung Cancer|Stage IV Non-small Cell Lung Cancer Jonsson Comprehensive Cancer Center|National Cancer Insti  ...more Jonsson Comprehensive Cancer Center|National Cancer Institute (NCI) January 2014 Phase 1
NCT01922583 Recruiting Non-small Cell Lung Cancer (NSCLC) National Taiwan University Hospital January 2014 Phase 2
NCT01854034 Recruiting Non Small Cell Lung Cancer Massachusetts General Hospital July 2013 Phase 2
NCT01772797 Completed Anaplastic Lymphoma Kinase (ALK)|Non-small Cell Lung Cancer Novartis Pharmaceuticals|Novartis June 2013 Phase 1
NCT01752400 Active, not recruiting Non Small Cell Lung Cancer Massachusetts General Hospital January 2013 Phase 2

view more

Chemical Information

Download Luminespib (AUY-922, NVP-AUY922) SDF
Molecular Weight (MW) 465.54
Formula

C26H31N3O5

CAS No. 747412-49-3
Storage 3 years -20℃powder
6 months-80℃in solvent
Synonyms VER-52296
Solubility (25°C) * In vitro DMSO 93 mg/mL warming (199.76 mM)
Ethanol 31 mg/mL (66.58 mM)
Water <1 mg/mL (<1 mM)
In vivo 1% DMSO+30% polyethylene glycol+1% Tween 80 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Chemical Name 5-(2,4-dihydroxy-5-isopropylphenyl)-N-ethyl-4-(4-(morpholinomethyl)phenyl)isoxazole-3-carboxamide

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

* Indicates a Required Field

Related HSP (e.g. HSP90) Products

  • PU-H71

    PU-H71 is a potent and selective inhibitor of HSP90 with IC50 of 51 nM. Phase 1.

  • KNK437

    KNK437 is a pan-HSP inhibitor, which inhibits the synthesis of inducible HSPs, including HSP105, HSP72, and HSP40.

  • VER155008

    VER-155008 is a potent Hsp70 family inhibitor with IC50 of 0.5 μM, 2.6 μM, and 2.6 μM in cell-free assays for HSP70, HSC70, and GRP78, respectively, >100-fold selectivity over HSP90.

  • 17-AAG (Tanespimycin)

    17-AAG (Tanespimycin) is a potent HSP90 inhibitor with IC50 of 5 nM in a cell-free assay, having a 100-fold higher binding affinity for HSP90 derived from tumour cells than HSP90 from normal cells. Phase 2.

    Features:Displays very low toxicity toward normal cells.

  • Ganetespib (STA-9090)

    Ganetespib (STA-9090) is an HSP90 inhibitor with IC50 of 4 nM in OSA 8 cells, induces apoptosis of OSA cells while normal osteoblasts are not affected; active metabolite of STA-1474. Phase 3.

  • 17-DMAG (Alvespimycin) HCl

    17-DMAG (Alvespimycin) HCl is a potent HSP90 inhibitor with IC50 of 62 nM in a cell-free assay. Phase 2.

    Features:A synthetic derivative Geldanamycin, with lower hepatotoxicity than parent antibiotic & higher potency and bioavailability than the similar derivative 17-AAG.

  • Geldanamycin

    Geldanamycin is a natural existing HSP90 inhibitor with Kd of 1.2 μM, specifically disrupts glucocorticoid receptor (GR)/HSP association.

  • HSP990 (NVP-HSP990)

    NVP-HSP990 (HSP990) is a novel, potent and selective HSP90 inhibitor for HSP90α/β with IC50 of 0.6 nM/0.8 nM.

    Features:NVP-HSP990 is an orally available HSP90 inhibitor and is structurally distinct from other clinical HSP90 inhibitors.

  • Elesclomol (STA-4783)

    Elesclomol (STA-4783) is a novel potent oxidative stress inducer that elicits pro-apoptosis events among tumor cells. Phase 3.

  • Onalespib (AT13387)

    Onalespib (AT13387) is a selective potent Hsp90 inhibitor with IC50 of 18 nM in A375 cells, displays a long duration of anti-tumor activity. Phase 2.

Recently Viewed Items

Tags: buy Luminespib (AUY-922, NVP-AUY922) | Luminespib (AUY-922, NVP-AUY922) supplier | purchase Luminespib (AUY-922, NVP-AUY922) | Luminespib (AUY-922, NVP-AUY922) cost | Luminespib (AUY-922, NVP-AUY922) manufacturer | order Luminespib (AUY-922, NVP-AUY922) | Luminespib (AUY-922, NVP-AUY922) distributor
×
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
Contact Us