Luminespib (AUY-922, NVP-AUY922)

Catalog No.S1069

Luminespib (AUY-922, NVP-AUY922) is a highly potent HSP90 inhibitor for HSP90α/β with IC50 of 13 nM /21 nM in cell-free assays, weaker potency against the HSP90 family members GRP94 and TRAP-1, exhibits the tightest binding of any small-molecule HSP90 ligand. Phase 2.

Price Stock Quantity  
USD 320 In stock
USD 160 In stock
USD 270 In stock
USD 470 In stock
Bulk Inquiry

Massive Discount Available

Free Overnight Delivery on all orders over $ 500.

Luminespib (AUY-922, NVP-AUY922) Chemical Structure

Luminespib (AUY-922, NVP-AUY922) Chemical Structure
Molecular Weight: 465.54

Validation & Quality Control

3 customer reviews :

Quality Control & MSDS

Related Compound Libraries

Luminespib (AUY-922, NVP-AUY922) is available in the following compound libraries:

HSP (e.g. HSP90) Inhibitors with Unique Features

  • Selective HSP90 Inhibitor

    NVP-BEP800 HSP90β-selective, IC50=58 nM.

  • Most Potent HSP90 Inhibitor

    KW-2478 HSP90, IC50=3.8 nM.

  • HSP90 Inhibitor in Clinical Trial

    17-AAG (Tanespimycin) Phase III for Gastrointestinal Stromal Tumors.

  • Newest HSP90 Inhibitor

    XL888 ATP-competitive inhibitor of HSP90 with IC50 of 24 nM.

Product Information

  • Compare HSP (e.g. HSP90) Inhibitors
    Compare HSP (e.g. HSP90) Products
  • Research Area
  • Luminespib (AUY-922, NVP-AUY922) Mechanism

Product Description

Biological Activity

Description Luminespib (AUY-922, NVP-AUY922) is a highly potent HSP90 inhibitor for HSP90α/β with IC50 of 13 nM /21 nM in cell-free assays, weaker potency against the HSP90 family members GRP94 and TRAP-1, exhibits the tightest binding of any small-molecule HSP90 ligand. Phase 2.
Targets HSP90α [1]
(Cell-free assay)
HSP90β [1]
(Cell-free assay)
IC50 13 nM 21 nM
In vitro NVP-AUY922 inhibits proliferation of various human cancer cell lines in vitro, with an average GI50 of 9 nM. [1] The IC50 values of NVP-AUY922 fall in the range of 2 to 40 nM in these gastric cancer cell lines. IC50 value for the BEAS-2B cells is 28.49 nM. Treatment with NVP-AUY922 does not influence the expression of HSP90, but expression of HSP70 gets elevated by NVP-AUY922 treatment. NVP-AUY922 increases the binding of HSP70 to HSP90. NVP-AUY922 causes p23 dissociation from the HSP90 complex and can then recruit HSP70 to the HSP90 complex. [1] After the treatment with NVP-AUY922, expression of receptor tyrosine kinases including VEGFR1, 2, 3 and PDGFRɑ is decreased. A decrease is also noticed in the expression of Akt and phospho-Akt. Meanwhile, treatment with NVP-AUY922 causes decreased expression of HER-2 in NCI-N87 cells. NVP-AUY922 treatment results in binding of HSP90 to client proteins and setting them up as targets for degradation by the proteasome. NVP-AUY922 can influence cell growth by affecting multiple signaling pathways. In addition, treatment with the proteasome inhibitor, MG132, restores expression of thymidylate synthase, which is decreased by NVP-AUY922. NVP-AUY922 increases the expression of cleaved caspase-3 leading to apoptosis in HSC-2 cells.[1]
Cell Data
Cell LinesAssay TypeConcentrationIncubation TimeFormulationActivity DescriptionPMID
CMKNGn1NmVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MWrJR|UxRTBwMECwNVI2KM7:TR?=NX\4ZZhVW0GQR1XS
MV-4-11M2LLWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NWW3To5uUUN3ME2wMlAxODV3ODFOwG0>NG[yZnVUSU6JRWK=
NALM-6MoDXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NEj2UnhKSzVyPUCuNFAxQDR{IN88US=>MWnTRW5ITVJ?
HOSNVnoeFlZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M17hTGlEPTB;MD6wNFE{QCEQvF2=NV\ONIdOW0GQR1XS
HT-144MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MkXLTWM2OD1yLkCwNVU2KM7:TR?=NF7XPVFUSU6JRWK=
SW1710NVzVO|FZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NVLBd4lRUUN3ME2wMlAxOTh4IN88US=>NGjOWVFUSU6JRWK=
TE-8NV;oXGRiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M{fScGlEPTB;MD6wNFI{PyEQvF2=M1vUNnNCVkeHUh?=
ES1MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NVPvWo0yUUN3ME2wMlAxOjZ4IN88US=>MVzTRW5ITVJ?
CCF-STTG1NVT4RoxQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MYjJR|UxRTBwMECyPVch|ryPNHXVNGlUSU6JRWK=
PSN1NHrkUXZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M3jnT2lEPTB;MD6wNFMyQCEQvF2=MV3TRW5ITVJ?
CAL-51NYC2SmVbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NUjSdFZZUUN3ME2wMlAxOzJ3IN88US=>M1:3bnNCVkeHUh?=
MCF7NYfVSJRuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NEf2VJVKSzVyPUCuNFA{OzVizszNNH;4UGJUSU6JRWK=
SK-HEP-1M37RT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7M4fOUmlEPTB;MD6wNFM{PiEQvF2=MWfTRW5ITVJ?
LCLC-103HNXfLNlVET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M2XNbmlEPTB;MD6wNFQ{KM7:TR?=NGfrWFBUSU6JRWK=
HMV-IINGTLfmFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NVXlOZplUUN3ME2wMlAxPDR7IN88US=>NIf6eGdUSU6JRWK=
MES-SAMljhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MXvJR|UxRTBwMEC0OVIh|ryPM1LEO3NCVkeHUh?=
SK-LMS-1MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M4PmW2lEPTB;MD6wNFQ2QCEQvF2=MXfTRW5ITVJ?
639-VM3e5ZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NXzuNpJIUUN3ME2wMlAxPDh3IN88US=>NXLCbnp1W0GQR1XS
SIG-M5NWHRc4wzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NHLOPY1KSzVyPUCuNFA1QDlizszNM2jwU3NCVkeHUh?=
LOUCYNFP4cGlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NICwN3NKSzVyPUCuNFA2ODVizszNNF7OOlZUSU6JRWK=
HSC-2MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MV3JR|UxRTBwMEC1NVgh|ryPMVHTRW5ITVJ?
EW-13MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MY\JR|UxRTBwMEC1NVgh|ryPMXPTRW5ITVJ?
RT-112NFO3OoJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M13lRWlEPTB;MD6wNFU{PSEQvF2=M1TFXHNCVkeHUh?=
NKM-1M1eyUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NF\Sem1KSzVyPUCuNFA2PDdizszNMYDTRW5ITVJ?
KYSE-180MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NV;6[3pEUUN3ME2wMlAxPTh4IN88US=>NHv5TpJUSU6JRWK=
SW1783MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M1LX[WlEPTB;MD6wNFU6OSEQvF2=Mn;sV2FPT0WU
A431NIPwe49Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MYjJR|UxRTBwMEC2NFch|ryPNULWbYRVW0GQR1XS
SK-OV-3NXjHSml[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NEXtPHFKSzVyPUCuNFA3OyEQvF2=MWrTRW5ITVJ?
RPMI-7951MnflS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MoHWTWM2OD1yLkCwOlMyKM7:TR?=NWXtXpZKW0GQR1XS
Capan-2NYTwV|F4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NFLK[otKSzVyPUCuNFA3OzhizszNMXrTRW5ITVJ?
HSC-3NYGxTm1jT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NX3iUnhUUUN3ME2wMlAxPjRzIN88US=>NFf3fFNUSU6JRWK=
786-0M3rWemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NYPPboY6UUN3ME2wMlAxPjZ|IN88US=>Mlu0V2FPT0WU
DaoyNEjSXGRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M2q1SmlEPTB;MD6wNFY6PSEQvF2=NHHD[5BUSU6JRWK=
KGNNEKyZoJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MVHJR|UxRTBwMEC3NFMh|ryPM1:yU3NCVkeHUh?=
EW-16NELl[5FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NUT1TVRDUUN3ME2wMlAxPzR7IN88US=>M1rkZ3NCVkeHUh?=
EW-7M1z2SWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M{jLTGlEPTB;MD6wNFc2PCEQvF2=NUXMU5ZKW0GQR1XS
IGROV-1MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MW\JR|UxRTBwMEC4NVQh|ryPNETmS4VUSU6JRWK=
8505CMVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MWXJR|UxRTBwMEC4NlEh|ryPMVrTRW5ITVJ?
RKONG\SV4dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=Ml;DTWM2OD1yLkCwPFI3KM7:TR?=MnrMV2FPT0WU
GDM-1M3r4VGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7Ml[1TWM2OD1yLkCwPFQh|ryPMmjVV2FPT0WU
IST-MEL1NUX0cnBUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MkfWTWM2OD1yLkCwPFUzKM7:TR?=MnfNV2FPT0WU
RPMI-6666MmLkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NWnzUYVLUUN3ME2wMlAxQDV{IN88US=>MlO3V2FPT0WU
SNG-MNV;6cY1PT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MYLJR|UxRTBwMEC4OVYh|ryPMYHTRW5ITVJ?
KS-1NXq0e2F{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NV3BV3JrUUN3ME2wMlAxQDV7IN88US=>Mn7BV2FPT0WU
RXF393NGKySGxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MlvlTWM2OD1yLkCwPFYh|ryPM3XsenNCVkeHUh?=
CAL-12TM4DYWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MYrJR|UxRTBwMEC5NlIh|ryPMUDTRW5ITVJ?
BFTC-905MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MV3JR|UxRTBwMEC5N|gh|ryPM4TLb3NCVkeHUh?=
SK-MES-1NH[4dYtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NV;SO|VHUUN3ME2wMlAxQTR3IN88US=>NWnsfIpsW0GQR1XS
BB30-HNCM4TDPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MnPkTWM2OD1yLkCwPVUzKM7:TR?=NEHKO2FUSU6JRWK=
AN3-CAM2HH[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7MnnWTWM2OD1yLkCxNFE4KM7:TR?=M1\tOXNCVkeHUh?=
EFO-27M3fnV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7MYTJR|UxRTBwMEGwNVch|ryPNV:y[ZNJW0GQR1XS
G-401NH7qWVFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NWfBZndGUUN3ME2wMlAyODJ3IN88US=>MlT2V2FPT0WU
BPH-1MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M3vacGlEPTB;MD6wNVA{KM7:TR?=Moi0V2FPT0WU
NCI-H727MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M3i1dmlEPTB;MD6wNVA{KM7:TR?=Mkn3V2FPT0WU
SNU-423NVja[m1XT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MWTJR|UxRTBwMEGwOVMh|ryPNF7XcXZUSU6JRWK=
KYSE-270M{j1fWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MmjqTWM2OD1yLkCxNFU6KM7:TR?=M4rz[HNCVkeHUh?=
AGSMX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NVTGUVh7UUN3ME2wMlAyODZzIN88US=>MXvTRW5ITVJ?
NCI-H2228M1XONmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MkLBTWM2OD1yLkCxNFY1KM7:TR?=M1n6fnNCVkeHUh?=
SW954MoLsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MmHDTWM2OD1yLkCxNFcyKM7:TR?=NGnqbYdUSU6JRWK=
769-PMVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MXrJR|UxRTBwMEGwO|Mh|ryPNVHkbZR7W0GQR1XS
BB49-HNCMoHRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?Ml7kTWM2OD1yLkCxNFc4KM7:TR?=NHf3[G5USU6JRWK=
IA-LMNVT1NFc1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NHfZcFBKSzVyPUCuNFExQDZizszNM2fBXXNCVkeHUh?=
NB69M3rTNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M3\tXWlEPTB;MD6wNVExOiEQvF2=NGjWWJhUSU6JRWK=
C8166NInYV4pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NUfMZnA1UUN3ME2wMlAyOTJ7IN88US=>MXLTRW5ITVJ?
NCI-H1299NWfy[mwyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MX\JR|UxRTBwMEGxOVQh|ryPNVXwUmlEW0GQR1XS
YKG-1NWnPU4pUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MW\JR|UxRTBwMEGxOkDPxE1?M{TLPXNCVkeHUh?=
PANC-03-27NYr6UW9VT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M37j[mlEPTB;MD6wNVE3OiEQvF2=MoPvV2FPT0WU
YTMmLUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?Mn:xTWM2OD1yLkCxNVc6KM7:TR?=Mn\SV2FPT0WU
CAL-85-1M3vrRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MYTJR|UxRTBwMEGxPVIh|ryPMWTTRW5ITVJ?
GT3TKBNH\QTpRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M361[GlEPTB;MD6wNVIxOiEQvF2=NFS1T2xUSU6JRWK=
BB65-RCCMl\US5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NF7pNZFKSzVyPUCuNFEzODRizszNNFH6PJpUSU6JRWK=
ES6NWjkfo9YT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NE\tfIpKSzVyPUCuNFEzPjFizszNMWTTRW5ITVJ?
MHH-ES-1NEjQfJdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NVfiOYVUUUN3ME2wMlAyOjZ|IN88US=>MnLTV2FPT0WU
QIMR-WILNHHydYtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NHfHTGZKSzVyPUCuNFEzPjlizszNNILkZpdUSU6JRWK=
SNU-C2BMVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NGK5UXpKSzVyPUCuNFEzPzJizszNMWfTRW5ITVJ?
OCI-AML2MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M3;qfWlEPTB;MD6wNVI5OSEQvF2=NHroO4FUSU6JRWK=
DU-145MkPDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M{HMeGlEPTB;MD6wNVI6KM7:TR?=MVLTRW5ITVJ?
SW982NV3YUXZwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MXXJR|UxRTBwMEGyPVMh|ryPNHrxWXhUSU6JRWK=
MFH-inoMli5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MortTWM2OD1yLkCxNlk{KM7:TR?=MWjTRW5ITVJ?
A427NXLUT4g3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M{PENmlEPTB;MD6wNVI6QSEQvF2=NUXmbmhUW0GQR1XS
LCLC-97TM1NEHndIhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MYPJR|UxRTBwMEGzJO69VQ>?MmTqV2FPT0WU
AM-38NXvLfZlKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MoDuTWM2OD1yLkCxN|AzKM7:TR?=NEHCVnFUSU6JRWK=
K5NVfVO3c4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MXzJR|UxRTBwMEGzNFgh|ryPM3XGe3NCVkeHUh?=
T84MkPDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MmHDTWM2OD1yLkCxN|MyKM7:TR?=Mk\aV2FPT0WU
TE-15NFXZ[nVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M1XBVWlEPTB;MD6wNVM{PiEQvF2=MWLTRW5ITVJ?
NCI-H460NU\2epAxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=Mn7RTWM2OD1yLkCxN|M3KM7:TR?=MmPMV2FPT0WU
NTERA-S-cl-D1MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NX7SfWFJUUN3ME2wMlAyOzN7IN88US=>MU\TRW5ITVJ?
KYSE-450MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MnjqTWM2OD1yLkCxN|Q6KM7:TR?=Ml3VV2FPT0WU
H4NEC1S29Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M{HGWGlEPTB;MD6wNVM3PiEQvF2=NWTadWFXW0GQR1XS
LC-2-adNXTxWVFnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=Mlr5TWM2OD1yLkCxN|ch|ryPMorjV2FPT0WU
GAMGNHvQWYJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NHfNcHRKSzVyPUCuNFE{PzFizszNMkjuV2FPT0WU
TK10M1vmZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7NXzNSYV2UUN3ME2wMlAyOzh{IN88US=>NWHCZ2VyW0GQR1XS
NCI-H2122M{XEUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7Mk\STWM2OD1yLkCxN|g1KM7:TR?=MYDTRW5ITVJ?
KM12NFG5OXpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NGjZfZFKSzVyPUCuNFE{QTlizszNM13NSHNCVkeHUh?=
CAL-39MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MVrJR|UxRTBwMEG0NkDPxE1?NFXyN|lUSU6JRWK=
RPMI-2650MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NW\RW|JTUUN3ME2wMlAyPDN{IN88US=>NFXoZoZUSU6JRWK=
KYSE-510NXvJelR[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MYXJR|UxRTBwMEG0OFIh|ryPMVXTRW5ITVJ?
KALS-1NGXYXJNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NIfldYhKSzVyPUCuNFE1PjZizszNMoPYV2FPT0WU
NCI-H1648MljzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?Mlv5TWM2OD1yLkCxOFk6KM7:TR?=NUj3OoRiW0GQR1XS
ES4NVq3OHM1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MUXJR|UxRTBwMEG1NFIh|ryPNXPHc21EW0GQR1XS
C-33-ANVPEXHRoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MVrJR|UxRTBwMEG1NFkh|ryPNV74[4dUW0GQR1XS
MIA-PaCa-2NWS3XVV2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M3jaOmlEPTB;MD6wNVUxQSEQvF2=NH35bIFUSU6JRWK=
BeckerMVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MlPCTWM2OD1yLkCxOVE1KM7:TR?=MmrkV2FPT0WU
HOP-62MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NF\IT3hKSzVyPUCuNFE2PDJizszNMVjTRW5ITVJ?
TE-1MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M{C0S2lEPTB;MD6wNVU5OSEQvF2=NGi0dIdUSU6JRWK=
KYSE-410Ml[yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M{DQ[WlEPTB;MD6wNVU5PiEQvF2=MX7TRW5ITVJ?
NOS-1M1voPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7Mlj6TWM2OD1yLkCxOVk{KM7:TR?=MkPwV2FPT0WU
MEL-HOMlf2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MkHUTWM2OD1yLkCxOlQ{KM7:TR?=M{LIV3NCVkeHUh?=
NCI-H1650NFTyfGdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NFm2R5dKSzVyPUCuNFE3PDZizszNM4S4cHNCVkeHUh?=
VMRC-RCZMlrMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M2q0UWlEPTB;MD6wNVY2OSEQvF2=MknjV2FPT0WU
HuP-T3Ml;sS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NEnaUGtKSzVyPUCuNFE3PTNizszNM1HsenNCVkeHUh?=
ACNM1rvPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7Ml;yTWM2OD1yLkCxOlU4KM7:TR?=M2DGdXNCVkeHUh?=
MEL-JUSONIHXdIxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M2jwOWlEPTB;MD6wNVY5OSEQvF2=M{jkUXNCVkeHUh?=
HT-1197MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NIDSRWJKSzVyPUCuNFE3QDVizszNNHfmepNUSU6JRWK=
NCI-H2030MoKzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NFe5clFKSzVyPUCuNFE3QTdizszNNUfWb|RyW0GQR1XS
A4-FukNHjHVlBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MnXpTWM2OD1yLkCxO|AzKM7:TR?=MVfTRW5ITVJ?
NCI-H292Mm\iS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M3;ZUWlEPTB;MD6wNVcxQSEQvF2=MWjTRW5ITVJ?
A2780MnH3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MVPJR|UxRTBwMEG3NVUh|ryPMor2V2FPT0WU
SF295NWfM[291T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NXLlUFdxUUN3ME2wMlAyPzJzIN88US=>NEjJXoRUSU6JRWK=
NCI-H810NHn6fJpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NEXmVm9KSzVyPUCuNFE4OjRizszNM1LW[nNCVkeHUh?=
ALL-POMYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NWTkdGRKUUN3ME2wMlAyPzN3IN88US=>MXfTRW5ITVJ?
MC-IXCM1Lsfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MkXDTWM2OD1yLkCxO|M3KM7:TR?=MmfJV2FPT0WU
NYNYnSToxVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NX7CVmllUUN3ME2wMlAyPzRizszNMl;xV2FPT0WU
OMC-1NHjHW3JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=Ml;mTWM2OD1yLkCxO|UyKM7:TR?=MVfTRW5ITVJ?
PANC-10-05MkHlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MlL4TWM2OD1yLkCxO|U2KM7:TR?=NWXa[ZNXW0GQR1XS
NCI-H2342NFH0[4ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NIjoOY9KSzVyPUCuNFE4PThizszNNEDvbphUSU6JRWK=
HGC-27NFuybmpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NHT4WotKSzVyPUCuNFE4PThizszNMofMV2FPT0WU
TE-12M1L3bmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MYjJR|UxRTBwMEG3O|Uh|ryPMl3IV2FPT0WU
MOLT-16Mn3zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NYnvRnMyUUN3ME2wMlAyPzh6IN88US=>NVntb4xZW0GQR1XS
HL-60MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NUnuOpdjUUN3ME2wMlAyQDB5IN88US=>Ml;ZV2FPT0WU
OVCAR-5MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M2TBUWlEPTB;MD6wNVgyOiEQvF2=M{PnSHNCVkeHUh?=
SK-LU-1MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NXPmfWxyUUN3ME2wMlAyQDR4IN88US=>MVrTRW5ITVJ?
MG-63NU[w[ZR6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MlPFTWM2OD1yLkCxPFc1KM7:TR?=MYfTRW5ITVJ?
8-MG-BAM4n5fWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M3rqeWlEPTB;MD6wNVg5PCEQvF2=NIjYRXRUSU6JRWK=
COR-L105NX3RUohOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MmLTTWM2OD1yLkCxPVEyKM7:TR?=M1;5PHNCVkeHUh?=
BHYMUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MV3JR|UxRTBwMEG5NVIh|ryPNWPLWWY3W0GQR1XS
SW620M3nXTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NELPU5ZKSzVyPUCuNFE6OTVizszNMVvTRW5ITVJ?
PC-14NUfEOIc{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M{jabmlEPTB;MD6wNVk{PCEQvF2=M{DONnNCVkeHUh?=
NCI-H522M3PSdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MUXJR|UxRTBwMEG5N|kh|ryPMVnTRW5ITVJ?
OE19Ml7mS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M4\NV2lEPTB;MD6wNVk2KM7:TR?=MnzOV2FPT0WU
RVH-421NEjWVoVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NFHuT21KSzVyPUCuNFE6PTdizszNNX7IOG5ZW0GQR1XS
TE-10MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NXHOOVdCUUN3ME2wMlAyQTd5IN88US=>NEDVOHhUSU6JRWK=
A101DM4XRWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7Mo\OTWM2OD1yLkCxPVg4KM7:TR?=MWrTRW5ITVJ?
HUTU-80MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NGTuV|dKSzVyPUCuNFIxODRizszNM3vXdXNCVkeHUh?=
KYSE-140NWC1fWpET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NEfmSopKSzVyPUCuNFIxOjRizszNNH7CUpZUSU6JRWK=
SNU-449MmPaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NYfF[Jg4UUN3ME2wMlAzODJ4IN88US=>NXnEWWpvW0GQR1XS
697MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NGTDOppKSzVyPUCuNFIxOzFizszNNGThO4tUSU6JRWK=
SJSA-1Mnu3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?Mlv2TWM2OD1yLkCyNFM4KM7:TR?=Ml;lV2FPT0WU
IGR-1MoS1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NYLDc|JLUUN3ME2wMlAzODVizszNM2\tV3NCVkeHUh?=
GCIYM{Dmcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MWfJR|UxRTBwMEKwOVUh|ryPMkDKV2FPT0WU
REHNUftcWJFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NX;1fI5TUUN3ME2wMlAzODV7IN88US=>Mn\UV2FPT0WU
A204MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MnPOTWM2OD1yLkCyNVE2KM7:TR?=NGTOTHZUSU6JRWK=
A388MoDuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NGHKPI5KSzVyPUCuNFIyOTVizszNMUXTRW5ITVJ?
NCI-H650MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NInENGJKSzVyPUCuNFIyOTdizszNMnqwV2FPT0WU
SW626NE\leoVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=Ml;WTWM2OD1yLkCyNVIh|ryPNYfvboxCW0GQR1XS
DoTc2-4510M1HYemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MlHiTWM2OD1yLkCyNVIzKM7:TR?=MnrtV2FPT0WU
HCE-4MlLLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M2rVXWlEPTB;MD6wNlE1PSEQvF2=MXfTRW5ITVJ?
DU-4475NVHpRXJIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MkHCTWM2OD1yLkCyNVUh|ryPNXfkSWg{W0GQR1XS
A375M4fK[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M1XISGlEPTB;MD6wNlE4OSEQvF2=NX7LUGs1W0GQR1XS
GB-1MkToS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MkToTWM2OD1yLkCyNVg5KM7:TR?=M4O0e3NCVkeHUh?=
CHP-212MlfoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M2TSemlEPTB;MD6wNlIyOiEQvF2=MkjWV2FPT0WU
HT-1080NWnt[IdvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MknHTWM2OD1yLkCyNlE1KM7:TR?=MXHTRW5ITVJ?
M059JMY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NVmwNJBPUUN3ME2wMlAzOjRzIN88US=>M13HOnNCVkeHUh?=
NMC-G1NFvzNlBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NYrnO3BMUUN3ME2wMlAzOjhizszNMUXTRW5ITVJ?
MRK-nu-1MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M3;iO2lEPTB;MD6wNlMh|ryPMn:wV2FPT0WU
MFE-296NIDtN5RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NVf0[oV{UUN3ME2wMlAzOzJ{IN88US=>NU\ofIRpW0GQR1XS
LOXIMVIMlz0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MnPlTWM2OD1yLkCyN|I{KM7:TR?=NUi0WJN6W0GQR1XS
CGTH-W-1MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M1H2NGlEPTB;MD6wNlMzQCEQvF2=MWrTRW5ITVJ?
CCRF-CEMMmD2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MV3JR|UxRTBwMEKzNlkh|ryPM1j6dHNCVkeHUh?=
ACHNMX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M2W3WGlEPTB;MD6wNlM1PSEQvF2=M1TLc3NCVkeHUh?=
NCI-H1355M{X2fWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NUTlPJJUUUN3ME2wMlAzPDBzIN88US=>NWfkZ28{W0GQR1XS
NCI-H1651MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MWLJR|UxRTBwMEK0N|Eh|ryPNVTwfYlXW0GQR1XS
KINGS-1M3OwPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MWfJR|UxRTBwMEK0N|Mh|ryPMYnTRW5ITVJ?
LS-123M17p[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MXrJR|UxRTBwMEK0N|Uh|ryPNI\r[YlUSU6JRWK=
SNB75M{PSbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7Ml;NTWM2OD1yLkCyOFY3KM7:TR?=MoDGV2FPT0WU
C3ANUT4RYVET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NVOwb3lQUUN3ME2wMlAzPDd3IN88US=>MmPTV2FPT0WU
HO-1-N-1MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NXrEWZpoUUN3ME2wMlAzPTR7IN88US=>NFr1TXVUSU6JRWK=
EHEBMo\4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MnPITWM2OD1yLkCyOVU2KM7:TR?=M3Lu[3NCVkeHUh?=
CAL-62MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MlfaTWM2OD1yLkCyOVch|ryPMV7TRW5ITVJ?
U-118-MGNF34[opIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M2PFcGlEPTB;MD6wNlU4PiEQvF2=M2Lt[XNCVkeHUh?=
HNM4HJd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7M{LTXGlEPTB;MD6wNlU6OyEQvF2=NXvuepBPW0GQR1XS
HTC-C3Mn7FS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MlTuTWM2OD1yLkCyOlA4KM7:TR?=NXvqeoVpW0GQR1XS
KYSE-520Mnz6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MUjJR|UxRTBwMEK2NVMh|ryPNVTIUVZKW0GQR1XS
MZ1-PCMlTMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NY\MN5Q1UUN3ME2wMlAzPjN7IN88US=>NWXUOopNW0GQR1XS
BCPAPMkfjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M4PWc2lEPTB;MD6wNlY1PiEQvF2=Mny2V2FPT0WU
RDM2npcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M2P0T2lEPTB;MD6wNlY2QCEQvF2=M3f1fXNCVkeHUh?=
NCI-H520M4WyO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7NYDoU2M6UUN3ME2wMlAzPjZ2IN88US=>MmjYV2FPT0WU
LXF-289Mon2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MVjJR|UxRTBwMEK2Olgh|ryPMWXTRW5ITVJ?
G-361NXe3V5NNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MYrJR|UxRTBwMEK2O|ch|ryPNXr2TlBWW0GQR1XS
LB996-RCCNXTiSnE2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MVLJR|UxRTBwMEK3NUDPxE1?MV3TRW5ITVJ?
COR-L23NGfJOVBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MnfQTWM2OD1yLkCyO|E{KM7:TR?=NFrSTWlUSU6JRWK=
GP5dNXzXVmJ7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M3\ObWlEPTB;MD6wNlczOyEQvF2=MkW3V2FPT0WU
SW1990MmfaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MWnJR|UxRTBwMEK3NlQh|ryPNG\QTolUSU6JRWK=
PA-1NFHWSZBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NVrjc5IyUUN3ME2wMlAzPzV3IN88US=>MofHV2FPT0WU
NCI-H2009NUG0bGszT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NVfWT3FbUUN3ME2wMlAzPzZizszNNGrMZmRUSU6JRWK=
SRNGX1RVVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NF;rZ5NKSzVyPUCuNFI4QDVizszNNYPIVoFWW0GQR1XS
Ca9-22NGXD[otIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MYnJR|UxRTBwMEK3PVYh|ryPMkS1V2FPT0WU
SCC-15M1\pfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NIHQdFNKSzVyPUCuNFI5ODFizszNMVTTRW5ITVJ?
ETK-1NFnMO4pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NGXJdnJKSzVyPUCuNFI5ODZizszNMYDTRW5ITVJ?
SCC-4MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MVnJR|UxRTBwMEK4NFkh|ryPMXTTRW5ITVJ?
5637NF:xSpJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MXrJR|UxRTBwMEK4NlIh|ryPMXrTRW5ITVJ?
EW-1MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MX3JR|UxRTBwMEK4NlIh|ryPNFrQcnNUSU6JRWK=
SW962Moe3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NVXoeoE6UUN3ME2wMlAzQDV{IN88US=>NGO0eFJUSU6JRWK=
HCE-TNVfBXZB5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MljOTWM2OD1yLkCyPFYh|ryPMnLjV2FPT0WU
NCI-H2405MkTPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M{m1[2lEPTB;MD6wNlg5PyEQvF2=MoDhV2FPT0WU
A2058M{XnNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NUHaSWZXUUN3ME2wMlAzQTJ7IN88US=>M1noPHNCVkeHUh?=
HCC2998M{f2cGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M2rJWGlEPTB;MD6wNlk1PSEQvF2=MYnTRW5ITVJ?
ONS-76M4W3UGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MWDJR|UxRTBwMEK5OVQh|ryPMnziV2FPT0WU
DBTRG-05MGMmOwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MmfqTWM2OD1yLkCyPVU2KM7:TR?=M1jBS3NCVkeHUh?=
HuCCT1MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M{jVdWlEPTB;MD6wNlk3OSEQvF2=MVLTRW5ITVJ?
J82NXK5[YxnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M17CTWlEPTB;MD6wN|AxPyEQvF2=MX7TRW5ITVJ?
MKN28M3fPXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MlLETWM2OD1yLkCzNFEzKM7:TR?=NYLERlNyW0GQR1XS
SW837MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NYe1Zlh5UUN3ME2wMlA{ODF2IN88US=>MYDTRW5ITVJ?
no-10M4HvT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7NGjaN4FKSzVyPUCuNFMxOTZizszNNHO4VYFUSU6JRWK=
BC-3NEX2bndIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=Mmi0TWM2OD1yLkCzNFE5KM7:TR?=MYLTRW5ITVJ?
no-11MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M2m4SmlEPTB;MD6wN|A1QCEQvF2=M4D4PHNCVkeHUh?=
8305CMXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MmG0TWM2OD1yLkCzNFczKM7:TR?=MUTTRW5ITVJ?
COLO-679MorlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MnfLTWM2OD1yLkCzNVA4KM7:TR?=NWDOWFVVW0GQR1XS
CESSMYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NYLvdHZoUUN3ME2wMlA{OTJizszNMUjTRW5ITVJ?
BFTC-909M3TXfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NVPTUW9iUUN3ME2wMlA{OTJ3IN88US=>MkHSV2FPT0WU
MZ2-MELMWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NGTEfolKSzVyPUCuNFMyPzdizszNNVrFWFhEW0GQR1XS
SW872M4DYeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M{jCPWlEPTB;MD6wN|IyPyEQvF2=NELBbYRUSU6JRWK=
LB831-BLCNF7jdYZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MoPsTWM2OD1yLkCzNlE6KM7:TR?=NXzofVJVW0GQR1XS
SK-UT-1MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MmS1TWM2OD1yLkCzNlIyKM7:TR?=NYDxWpZGW0GQR1XS
NCI-H1734NVrmZZBvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MY\JR|UxRTBwMEOyN{DPxE1?MnTFV2FPT0WU
OVCAR-8MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NWLYTZFjUUN3ME2wMlA{OjhzIN88US=>MY\TRW5ITVJ?
NCI-H2087NF;O[JFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NFXD[YRKSzVyPUCuNFMzQDlizszNMoixV2FPT0WU
U-87-MGM{PjRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7Ml\zTWM2OD1yLkCzNlkh|ryPNHHuS4lUSU6JRWK=
BC-1NEf0bGpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NFLWbXJKSzVyPUCuNFM{PjdizszNMmLvV2FPT0WU
ES7NFvKT21Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M{fxSGlEPTB;MD6wN|M4PCEQvF2=NHvrOoRUSU6JRWK=
DaudiM2\vTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NYTFWVQxUUN3ME2wMlA{Ozd4IN88US=>M3z1THNCVkeHUh?=
RS4-11MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NYCwVpRHUUN3ME2wMlA{Ozh|IN88US=>NVj3SI1LW0GQR1XS
JiyoyeP-2003M{nSW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7NWLRTJY5UUN3ME2wMlA{Ozh6IN88US=>NYPyT40zW0GQR1XS
BL-70M3;mNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M2TDdGlEPTB;MD6wN|M5QSEQvF2=NF74S21USU6JRWK=
OS-RC-2MmK0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NIjRVJlKSzVyPUCuNFM{QTZizszNM174WHNCVkeHUh?=
SF268NEDm[o9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MYjJR|UxRTBwMEO0NFEh|ryPNGfwO25USU6JRWK=
BV-173M1\zOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MlP3TWM2OD1yLkCzOFI3KM7:TR?=MnrGV2FPT0WU
DMS-273NF:wNZBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NXW5cVNMUUN3ME2wMlA{PDd7IN88US=>M4LJdHNCVkeHUh?=
22RV1MmrES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M1TmWGlEPTB;MD6wN|UxPyEQvF2=NU\VWIt[W0GQR1XS
ES8NGCzd2JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NWL2dW5yUUN3ME2wMlA{PTN6IN88US=>MXHTRW5ITVJ?
KYSE-150M1jyemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MofXTWM2OD1yLkCzOlA5KM7:TR?=M1X1d3NCVkeHUh?=
HCC1569NGLFWmlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M2nnbGlEPTB;MD6wN|YxQCEQvF2=NWf6TZY6W0GQR1XS
NB5NFrOfZhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MnLZTWM2OD1yLkCzOlE{KM7:TR?=NI\FNFVUSU6JRWK=
G-402MmC2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NWrJXpEzUUN3ME2wMlA{PjF2IN88US=>M4TnPHNCVkeHUh?=
NCI-H1693NX3iV3FCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M2KzemlEPTB;MD6wN|YyPyEQvF2=NV;TS3pVW0GQR1XS
LB2241-RCCNIXtbmlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M2T0c2lEPTB;MD6wN|Y1OiEQvF2=MUfTRW5ITVJ?
KP-4MkDnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NVXrUWk5UUN3ME2wMlA{PjZ|IN88US=>NW\T[VYzW0GQR1XS
ML-2NF3OdXVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NXu2S3NIUUN3ME2wMlA{PjdzIN88US=>NIfkXI5USU6JRWK=
KU812MmHBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MYDJR|UxRTBwMEO2PFQh|ryPNVXpOmh{W0GQR1XS
LS-411NM3H6NGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NUnVfIZKUUN3ME2wMlA{PzNzIN88US=>MWnTRW5ITVJ?
OAW-42NID1UHJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NHf3SWRKSzVyPUCuNFM4PDdizszNNETONXlUSU6JRWK=
HCC38NHrpeYRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MWrJR|UxRTBwMEO3O|Eh|ryPNFnPdJlUSU6JRWK=
Ca-SkiNUGxe2oyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MlfqTWM2OD1yLkCzO|g1KM7:TR?=MoTzV2FPT0WU
Calu-3NYW3bFBiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NIXFUJBKSzVyPUCuNFM4QDlizszNNFnrZoNUSU6JRWK=
KYSE-70NXv3[mx1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MUnJR|UxRTBwMEO4NVIh|ryPNXjYbnhDW0GQR1XS
D-392MGMnfFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MmDrTWM2OD1yLkCzPFQzKM7:TR?=NIK5dZhUSU6JRWK=
OVCAR-4MkfGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MUDJR|UxRTBwMEO4OVgh|ryPNWLteVRMW0GQR1XS
Detroit562NIOxXXNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=Ml3NTWM2OD1yLkCzPFczKM7:TR?=Ml;KV2FPT0WU
HELNHL1dWlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MnnYTWM2OD1yLkCzPFkyKM7:TR?=MVHTRW5ITVJ?
MONO-MAC-6M2TwWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M{fFR2lEPTB;MD6wN|g6OyEQvF2=NHHtVmNUSU6JRWK=
LoVoNFPyNGRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MV3JR|UxRTBwMEO5N|Mh|ryPM4H5NHNCVkeHUh?=
U-2-OSMWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M4jJPWlEPTB;MD6wN|k{PSEQvF2=MmWxV2FPT0WU
A172MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MmfjTWM2OD1yLkCzPVUh|ryPMkjzV2FPT0WU
OCUB-MMmrqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MVjJR|UxRTBwMEO5OlEh|ryPMmPVV2FPT0WU
SW48MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MWTJR|UxRTBwMESwN|Eh|ryPNVPkWnVYW0GQR1XS
HC-1MnXUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M2C1fmlEPTB;MD6wOFA3QSEQvF2=NYm2XGRjW0GQR1XS
KOSC-2NVvqbYNLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MY\JR|UxRTBwMESxNUDPxE1?MkThV2FPT0WU
HDLM-2NFXNO|BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M1LNSmlEPTB;MD6wOFEyPCEQvF2=Mo\nV2FPT0WU
CTV-1Mki4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MlS3TWM2OD1yLkC0NVE3KM7:TR?=M2Hi[nNCVkeHUh?=
SH-4M4rpdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MV\JR|UxRTBwMESxOFEh|ryPMXjTRW5ITVJ?
SW756MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NITodY9KSzVyPUCuNFQyPTdizszNNX;vfnI6W0GQR1XS
GCTMYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MnXzTWM2OD1yLkC0NVYyKM7:TR?=NXPzNotjW0GQR1XS
CHL-1MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NIDGNJNKSzVyPUCuNFQyPjlizszNNUC3dVJVW0GQR1XS
LAMA-84MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MVrJR|UxRTBwMESxO|Eh|ryPNIrIUHJUSU6JRWK=
LS-1034MlXXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NXXzfII6UUN3ME2wMlA1OTlzIN88US=>MlK1V2FPT0WU
NCI-H358NGXteWFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NWD3SnlUUUN3ME2wMlA1OjF{IN88US=>MXfTRW5ITVJ?
NB13NFXKcWdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MlnwTWM2OD1yLkC0NlI4KM7:TR?=NHSzdZVUSU6JRWK=
TE-9NUeydGl2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MkHiTWM2OD1yLkC0NlM4KM7:TR?=MlnmV2FPT0WU
OE33MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NUjkZZM2UUN3ME2wMlA1OjRzIN88US=>M2XLPHNCVkeHUh?=
CAL-120M1[yTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MlTSTWM2OD1yLkC0NlQyKM7:TR?=NXHFUHNZW0GQR1XS
DJM-1MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NV\GU3RPUUN3ME2wMlA1Ojd{IN88US=>NX:wWVBuW0GQR1XS
SK-MEL-24M37Mdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NF62VFNKSzVyPUCuNFQzQDNizszNMVrTRW5ITVJ?
VA-ES-BJM1yyXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NU\ETWpoUUN3ME2wMlA1Ojl{IN88US=>M1HZTHNCVkeHUh?=
MMAC-SFM2TuUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M{LoSWlEPTB;MD6wOFI6PyEQvF2=M4P0UHNCVkeHUh?=
MZ7-melMUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MVPJR|UxRTBwMESzN{DPxE1?M2ni[3NCVkeHUh?=
BxPC-3MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MoPxTWM2OD1yLkC0N|QyKM7:TR?=MmHOV2FPT0WU
HT-29MmHqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MmT6TWM2OD1yLkC0N|U4KM7:TR?=NYXmSYx5W0GQR1XS
SK-MEL-30M{TNWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7Mlj0TWM2OD1yLkC0N|YzKM7:TR?=MVXTRW5ITVJ?
CAL-33NEXOS2JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NGfEUnJKSzVyPUCuNFQ{PzVizszNMVrTRW5ITVJ?
COLO-680NNHvPN|lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NV7O[5g5UUN3ME2wMlA1PDB5IN88US=>NXvL[29LW0GQR1XS
NH-12MkT1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MVnJR|UxRTBwMES0OEDPxE1?NUPFOXdWW0GQR1XS
HCC1937MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MVXJR|UxRTBwMES0OVYh|ryPMUHTRW5ITVJ?
IMR-5M33UZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7NITaSWVKSzVyPUCuNFQ1QSEQvF2=NFTDcpFUSU6JRWK=
MC-CARM2XsSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M1j0N2lEPTB;MD6wOFU3QSEQvF2=MVLTRW5ITVJ?
NCI-H747MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NV[3UldGUUN3ME2wMlA1PTdizszNNEj2fIhUSU6JRWK=
NCI-H1792Mn;2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M1LTSmlEPTB;MD6wOFU5OSEQvF2=M1mwbHNCVkeHUh?=
SW13NVzpdGxsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NV3pfHFLUUN3ME2wMlA1PTlizszNNXTNWVVxW0GQR1XS
MLMANF\iVmVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NYjqfm95UUN3ME2wMlA1PjB7IN88US=>M3TBdHNCVkeHUh?=
U251NYK2XFEzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M2C2XGlEPTB;MD6wOFc3OyEQvF2=M4K5c3NCVkeHUh?=
U031M3r5VWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7Ml6wTWM2OD1yLkC0O|cyKM7:TR?=Mo\mV2FPT0WU
ME-180MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NVvOOI5mUUN3ME2wMlA1Pzh{IN88US=>NU\S[Hl[W0GQR1XS
SK-MEL-3NGDBeGlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=Mn;yTWM2OD1yLkC0PFAzKM7:TR?=NH[5NnZUSU6JRWK=
MOLT-4NYqySY1GT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NXe4T5hjUUN3ME2wMlA1QDB|IN88US=>M4f2VXNCVkeHUh?=
PF-382NGj6WXBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NYPUelREUUN3ME2wMlA1QDJ4IN88US=>NXjke4hEW0GQR1XS
NUGC-3MomxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M3ricmlEPTB;MD6wOFgzPyEQvF2=NVz0cGRRW0GQR1XS
NCI-H1417M4P3Omdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MX\JR|UxRTBwMES4PUDPxE1?MoLHV2FPT0WU
COLO-205M2jsdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NFHUc2NKSzVyPUCuNFQ6OTlizszNMkDZV2FPT0WU
TE-441-TM{TMe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7Ml\CTWM2OD1yLkC0PVMh|ryPNVfyNoZTW0GQR1XS
MKN1NUfxVHZnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MYXJR|UxRTBwMES5N{DPxE1?M{DzbHNCVkeHUh?=
UM-UC-3NHL2eWRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MnrBTWM2OD1yLkC0PVUh|ryPMVfTRW5ITVJ?
SF126NX;UZ4tHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=Ml7KTWM2OD1yLkC1NFEh|ryPNV3hWHJ3W0GQR1XS
LB1047-RCCNV;XTo4yT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MX3JR|UxRTBwMEWwN|Eh|ryPMlW5V2FPT0WU
A253MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MYTJR|UxRTBwMEWwOVIh|ryPM1r1NHNCVkeHUh?=
NCI-H1963MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NVzuT2RrUUN3ME2wMlA2OTd4IN88US=>Mne3V2FPT0WU
VM-CUB-1MlPxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NF3FOY5KSzVyPUCuNFU{OTFizszNNFL2d|ZUSU6JRWK=
T-24MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M4W0OmlEPTB;MD6wOVM5PCEQvF2=MorSV2FPT0WU
K-562NVPiPId5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NVjoUoRiUUN3ME2wMlA2Ozh5IN88US=>MUDTRW5ITVJ?
ARH-77M1fyPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NXLGSXdmUUN3ME2wMlA2Ozl3IN88US=>M4nEWHNCVkeHUh?=
CA46M1LZOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MVTJR|UxRTBwMEW0N{DPxE1?MlnsV2FPT0WU
HCC70MnK0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MVPJR|UxRTBwMEW0OVIh|ryPMWXTRW5ITVJ?
ST486NV7EbolkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=Mn7PTWM2OD1yLkC1OVI2KM7:TR?=NUHxN2ZtW0GQR1XS
COLO-741M4\sTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M1;COWlEPTB;MD6wOVU{OSEQvF2=M1\RWHNCVkeHUh?=
SK-PN-DWMlLrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MVLJR|UxRTBwMEW1PFgh|ryPNHPucY9USU6JRWK=
BL-41NHLmfWxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MnrsTWM2OD1yLkC1OVk3KM7:TR?=MkC4V2FPT0WU
D-263MGNFTRT3BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MnrrTWM2OD1yLkC1Olg{KM7:TR?=M3LMPHNCVkeHUh?=
KE-37MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MYLJR|UxRTBwMEW2PFMh|ryPM1fJOHNCVkeHUh?=
LU-134-AMXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MmPFTWM2OD1yLkC1O|E2KM7:TR?=NX3GTlBZW0GQR1XS
HCC2157M2e0XGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NXPCPVR4UUN3ME2wMlA2PzN|IN88US=>Ml7GV2FPT0WU
GAKMVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M37pc2lEPTB;MD6wOVc{PCEQvF2=NUX4OoN7W0GQR1XS
IST-SL2Ml\aS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NGPUbIRKSzVyPUCuNFU4PDNizszNM3;PWXNCVkeHUh?=
KMOE-2NXTRWmNPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NV\SZpI5UUN3ME2wMlA2PzR7IN88US=>M3HZTXNCVkeHUh?=
SW1573NUfPTHhST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NHu1VVlKSzVyPUCuNFU5ODJizszNM2\UdnNCVkeHUh?=
SCC-9NYXsWGtJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MUnJR|UxRTBwMEW4O{DPxE1?MnjZV2FPT0WU
MDA-MB-361NXmx[ZB2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M4X6RWlEPTB;MD6wOVg4OiEQvF2=NYXWTnFwW0GQR1XS
BHT-101NHK3[3dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NIC1W2tKSzVyPUCuNFU5PzZizszNNWi3ZoRQW0GQR1XS
NCI-H1770M37CV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7NF\DfJJKSzVyPUCuNFU5PzlizszNM4fKS3NCVkeHUh?=
UACC-893MoS4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MnzLTWM2OD1yLkC1PFk3KM7:TR?=NGTxe|ZUSU6JRWK=
NCI-H226MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NUX4XYM6UUN3ME2wMlA2QTh6IN88US=>MXzTRW5ITVJ?
HLENYPjeWY4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M3jZTmlEPTB;MD6wOlA5OiEQvF2=M{TpO3NCVkeHUh?=
NCI-H1703MlGyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M4m3OmlEPTB;MD6wOlE4QCEQvF2=NUjYUVNQW0GQR1XS
KURAMOCHIMlrHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NULyfWZxUUN3ME2wMlA3OTh7IN88US=>MYTTRW5ITVJ?
RH-1MoXoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MnjPTWM2OD1yLkC2NlMh|ryPNFnXT2dUSU6JRWK=
DSH1MoG1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MUPJR|UxRTBwME[yO{DPxE1?NF\XZppUSU6JRWK=
CAMA-1NYTHS3d4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NWXuS4RVUUN3ME2wMlA3OzB|IN88US=>M1fOXXNCVkeHUh?=
NCI-H1437NI\aSYJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MUDJR|UxRTBwME[zNlgh|ryPNIS4c2tUSU6JRWK=
HuP-T4NGnXS4NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NGGyWI9KSzVyPUCuNFY2QDZizszNMm\wV2FPT0WU
HCT-15M4S2RWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NWK3NnlGUUN3ME2wMlA3PTl5IN88US=>MWDTRW5ITVJ?
NCCITNV;wcWhPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=Ml;ZTWM2OD1yLkC2OlA1KM7:TR?=M2f6N3NCVkeHUh?=
BOKUM2TVN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7NUnYU4poUUN3ME2wMlA3Pjd2IN88US=>NIrjVYlUSU6JRWK=
FADUNHOxeHFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MUTJR|UxRTBwME[3OFUh|ryPM3P2PXNCVkeHUh?=
SUP-T1MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NHzKcVNKSzVyPUCuNFY4PiEQvF2=MmDMV2FPT0WU
L-363M3\oemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NVP3eXYyUUN3ME2wMlA3QTBzIN88US=>MWjTRW5ITVJ?
KNS-81-FDMUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M1LjXmlEPTB;MD6wOlkyQCEQvF2=MlPzV2FPT0WU
SU-DHL-1Ml\IS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NH\OelNKSzVyPUCuNFY6OiEQvF2=MUPTRW5ITVJ?
HuH-7MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M4S3bWlEPTB;MD6wO|A{PSEQvF2=M3fRRXNCVkeHUh?=
BT-474M3zDNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MWLJR|UxRTBwMEewOlEh|ryPNHPtTmZUSU6JRWK=
CAPAN-1NWPu[ot3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NXjxdmo3UUN3ME2wMlA4OTR|IN88US=>MWrTRW5ITVJ?
HEC-1MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MVrJR|UxRTBwMEexOlEh|ryPMoDRV2FPT0WU
NOMO-1MmLkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NUe4eYJQUUN3ME2wMlA4OTd{IN88US=>MmXYV2FPT0WU
KM-H2NV;NVJFvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=Mlz4TWM2OD1yLkC3NlQyKM7:TR?=M{j6XHNCVkeHUh?=
EB2NV;0TXZ{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=Ml24TWM2OD1yLkC3Nlg2KM7:TR?=NYHpcWkyW0GQR1XS
LU-99ANGHxcVBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MYDJR|UxRTBwMEeyPFch|ryPMlviV2FPT0WU
WSU-NHLNHPidVhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NUmxRlZsUUN3ME2wMlA4OzJ7IN88US=>NIm0NppUSU6JRWK=
Calu-1MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MVLJR|UxRTBwMEezN|Ih|ryPNFTUN5BUSU6JRWK=
U-698-MMlzBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NVL3Nm9QUUN3ME2wMlA4Ozh{IN88US=>M1H2cnNCVkeHUh?=
T98GM{XpU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7MYnJR|UxRTBwMEe0NlEh|ryPM3zLS3NCVkeHUh?=
GI-ME-NNWXUXJhjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M{e5e2lEPTB;MD6wO|QzPiEQvF2=NXz1W2ROW0GQR1XS
LS-513M1PaZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MWrJR|UxRTBwMEe0OVYh|ryPMm\QV2FPT0WU
UACC-257M133[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7MlTXTWM2OD1yLkC3OVA2KM7:TR?=NXHh[lhwW0GQR1XS
DK-MGMnP6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MoGyTWM2OD1yLkC3OVI3KM7:TR?=NIrPbYNUSU6JRWK=
EW-11NVPueIlLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MXzJR|UxRTBwMEe1N|Uh|ryPM{DFfnNCVkeHUh?=
CHP-126NFrBNWZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NHvNZXVKSzVyPUCuNFc2PjVizszNNVHxWlB2W0GQR1XS
Saos-2M1XLOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NIj6TWpKSzVyPUCuNFc2QTdizszNMmjZV2FPT0WU
Ramos-2G6-4C10M2rQd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7M2q1XmlEPTB;MD6wO|Y1QCEQvF2=NF;EV5FUSU6JRWK=
L-428MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?Mn:0TWM2OD1yLkC3O|A1KM7:TR?=M1iyOnNCVkeHUh?=
HOP-92MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NV\DT5luUUN3ME2wMlA4PzFzIN88US=>MWjTRW5ITVJ?
PANC-08-13NXT0dm5[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NFTPVo1KSzVyPUCuNFc4OTZizszNNF7yR5NUSU6JRWK=
TURM2[5cmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NYflRlB3UUN3ME2wMlA4PzN|IN88US=>MXrTRW5ITVJ?
DMS-153Ml\lS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NWnTPJBFUUN3ME2wMlA4PzN3IN88US=>NH7wcmRUSU6JRWK=
NCI-N87MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MVvJR|UxRTBwMEe3PVkh|ryPMYDTRW5ITVJ?
ESS-1M3nmSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M2\1UGlEPTB;MD6wO|g3QCEQvF2=MVTTRW5ITVJ?
CP66-MELM{HnOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M4ey[WlEPTB;MD6wO|g5PyEQvF2=M{Xic3NCVkeHUh?=
NCI-SNU-1M4jXemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NWXG[mhJUUN3ME2wMlA4QDh6IN88US=>MlroV2FPT0WU
Calu-6MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NXrqTZhPUUN3ME2wMlA4QTZ3IN88US=>MkPmV2FPT0WU
COLO-668NWO2cZNZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NILiZnFKSzVyPUCuNFc6QDRizszNMlrQV2FPT0WU
SK-CO-1NH\S[WZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=Mn;QTWM2OD1yLkC3PVkzKM7:TR?=NIDSfW5USU6JRWK=
NCI-H2347NFq3R41Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NHTMRVZKSzVyPUCuNFgxOjhizszNM4PMcXNCVkeHUh?=
CAL-27NGXueZJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NYCzd4RYUUN3ME2wMlA5OTV4IN88US=>M4e3NXNCVkeHUh?=
COLO-684NYLkeIZTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NIriZ2lKSzVyPUCuNFgyPThizszNNHvEbllUSU6JRWK=
LNCaP-Clone-FGCMmi4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M17MSmlEPTB;MD6wPFE3PSEQvF2=MXPTRW5ITVJ?
NCI-H1304MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NYn1[mhFUUN3ME2wMlA5OjdzIN88US=>NGq1SY1USU6JRWK=
KP-N-YSMkXES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MXLJR|UxRTBwMEizOFUh|ryPNEDCb5JUSU6JRWK=
CP50-MEL-BM{PQU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7MljJTWM2OD1yLkC4N|Y5KM7:TR?=NXHHTG81W0GQR1XS
LAN-6MkPLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MX7JR|UxRTBwMEi0PVgh|ryPM3[3SXNCVkeHUh?=
ABC-1MoDCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MU\JR|UxRTBwMEi3OVkh|ryPNUnGXpJPW0GQR1XS
ES3NW\rT3p[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MYLJR|UxRTBwMEi3OlMh|ryPNYnZe|lnW0GQR1XS
COLO-792NV7ZU4Q2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MkLBTWM2OD1yLkC4PFU2KM7:TR?=NVT3VmExW0GQR1XS
J-RT3-T3-5Mli4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NH\KcG1KSzVyPUCuNFg6PjhizszNMXXTRW5ITVJ?
EFO-21NX[2fYpOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MVPJR|UxRTBwMEi5PVEh|ryPM3LXUnNCVkeHUh?=
MDA-MB-231MlTMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?Mn7lTWM2OD1yLkC5NFgzKM7:TR?=M{T3eXNCVkeHUh?=
SBC-5NYH4ZZRZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NFnLbnpKSzVyPUCuNFkyQTNizszNMVTTRW5ITVJ?
SASMnXpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MlH1TWM2OD1yLkC5NlE2KM7:TR?=M3:1NHNCVkeHUh?=
SNU-387NWq5OYpyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NU[wWHViUUN3ME2wMlA6OjF6IN88US=>M1HSWHNCVkeHUh?=
EVSA-TNXjIeGJvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M3\qV2lEPTB;MD6wPVI3PSEQvF2=MmfHV2FPT0WU
MHH-PREB-1NV65So5mT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MX7JR|UxRTBwMEmzNUDPxE1?NX7lbm1NW0GQR1XS
KARPAS-45NIrGVpFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M3m4d2lEPTB;MD6wPVM1PSEQvF2=MXHTRW5ITVJ?
SJRH30MlP3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?Mk\ZTWM2OD1yLkC5OFQ1KM7:TR?=MnexV2FPT0WU
JEG-3M1jBXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M3HObWlEPTB;MD6wPVUxPSEQvF2=M2X2fnNCVkeHUh?=
NB12MmDoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M{jNemlEPTB;MD6wPVUyQCEQvF2=NWPiNolqW0GQR1XS
HCC1419M4CyRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MlThTWM2OD1yLkC5OVQyKM7:TR?=NXvqTIxlW0GQR1XS
HCC1599NGWzNXRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NWPGRlVtUUN3ME2wMlA6PjBzIN88US=>NVHCW4xSW0GQR1XS
IPC-298MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NXmw[IN[UUN3ME2wMlA6PjR2IN88US=>NVPJeWQxW0GQR1XS
MPP-89MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?Mn3wTWM2OD1yLkC5O|IyKM7:TR?=NU\Kfm9ZW0GQR1XS
HT-1376M4i5W2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7MXnJR|UxRTBwMEm4OlEh|ryPMkTmV2FPT0WU
MDA-MB-468Mk[wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M132fWlEPTB;MD6wPVk5PSEQvF2=NETEenlUSU6JRWK=
HCC2218M13FTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MYPJR|UxRTBwMEm5PVkh|ryPMly0V2FPT0WU
LK-2M{T1V2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7M2n1ZWlEPTB;MD6xNFE4PiEQvF2=NUPNdXdvW0GQR1XS
GR-STMonxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NWj3[Ig2UUN3ME2wMlExOjFizszNMWLTRW5ITVJ?
PFSK-1M{HM[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MYrJR|UxRTBwMUCyOlch|ryPMUnTRW5ITVJ?
NCI-H2052NFnQelhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NHLWeo9KSzVyPUCuNVA1ODdizszNMm\zV2FPT0WU
A673MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MUDJR|UxRTBwMUC0N|Eh|ryPMnfpV2FPT0WU
EKVXM33abmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NXjoOHJ7UUN3ME2wMlExPDh|IN88US=>M{i3THNCVkeHUh?=
23132-87NWi2WHd4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MlnrTWM2OD1yLkGwOFg5KM7:TR?=M1vLcnNCVkeHUh?=
EW-18MmP1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NF25PIRKSzVyPUCuNVA3ODRizszNNXGzdHFNW0GQR1XS
KU-19-19M4[0[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7NXG3NWxxUUN3ME2wMlExQDF5IN88US=>MlmyV2FPT0WU
NCI-H441NFTBXlJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MUnJR|UxRTBwMUC4PVkh|ryPM4CzdXNCVkeHUh?=
COLO-824NE\K[XJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NXfwVINZUUN3ME2wMlEyODJizszNNGrldo9USU6JRWK=
HCC1806MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MlnLTWM2OD1yLkGxNVA5KM7:TR?=NX;U[XFnW0GQR1XS
SK-MM-2M2DTfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MV;JR|UxRTBwMUGxOFUh|ryPNYPrNnM4W0GQR1XS
DELNYn3XYV{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MVTJR|UxRTBwMUGxPVIh|ryPMlXIV2FPT0WU
NCI-H661M1S3dGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NUT4XlA4UUN3ME2wMlEyOTl3IN88US=>NUPlblJTW0GQR1XS
LC4-1M2rRW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7NWnieHg3UUN3ME2wMlEyPDZ4IN88US=>NELuRYdUSU6JRWK=
BENM1PDW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7NYDsbVhRUUN3ME2wMlEyPjB5IN88US=>MUTTRW5ITVJ?
RPMI-8226MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MVnJR|UxRTBwMUG3NVkh|ryPMljGV2FPT0WU
AU565M4fRVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NGS5Nm1KSzVyPUCuNVE5OzFizszNMYHTRW5ITVJ?
CAS-1MoG2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M1z3Z2lEPTB;MD6xNVk3PCEQvF2=NWnJOJFUW0GQR1XS
UACC-62MoXUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NYjTVFdPUUN3ME2wMlEzOTJizszNNVfJNG5pW0GQR1XS
C-4-IINXXkZ4diT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NVTYNopyUUN3ME2wMlEzOTdizszNNH6yR4NUSU6JRWK=
DMS-53NVK1dpZpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MoW3TWM2OD1yLkGyNlc3KM7:TR?=M3Xqc3NCVkeHUh?=
SK-MEL-2Ml\kS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M3Pnd2lEPTB;MD6xNlQ3KM7:TR?=MmqyV2FPT0WU
S-117NFXCWW5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NGLjcIdKSzVyPUCuNVI3PzRizszNMYfTRW5ITVJ?
ChaGo-K-1Ml;YS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NHvOS|BKSzVyPUCuNVI3QTlizszNMoK0V2FPT0WU
KMS-12-PENFLZXY9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MWDJR|UxRTBwMUK4Olkh|ryPMXzTRW5ITVJ?
PC-3NVPjcVhyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MojOTWM2OD1yLkGzNVc4KM7:TR?=MnjzV2FPT0WU
RERF-LC-MSNUL4SmVST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M1\mWmlEPTB;MD6xN|Q{KM7:TR?=M3PJfnNCVkeHUh?=
GMS-10NH;uTGlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=Ml3lTWM2OD1yLkGzOFQ1KM7:TR?=M{DZUnNCVkeHUh?=
CTB-1MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NYDXVFFrUUN3ME2wMlE{PDZ7IN88US=>MnnNV2FPT0WU
SCC-25M{LMcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M4\zfmlEPTB;MD6xN|U5QCEQvF2=NWW1PFhUW0GQR1XS
NCI-H1755MmDmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MV3JR|UxRTBwMUO4Nlch|ryPM4H4T3NCVkeHUh?=
D-542MGM{L1bmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M2LDV2lEPTB;MD6xN|k3PSEQvF2=MkfYV2FPT0WU
KARPAS-422NVHITI1qT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MVPJR|UxRTBwMUSwN|ch|ryPNUjt[49xW0GQR1XS
OVCAR-3M33BSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7Mof4TWM2OD1yLkG0NFc5KM7:TR?=M{LybXNCVkeHUh?=
NCI-H1092MlnpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NV7tcpFVUUN3ME2wMlE1OTBzIN88US=>MWnTRW5ITVJ?
HHMnzvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NILJVWtKSzVyPUCuNVQzODFizszNM2myenNCVkeHUh?=
NB1M4DLV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7M4fyWmlEPTB;MD6xOFQzPiEQvF2=MlHxV2FPT0WU
HD-MY-ZMYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MonuTWM2OD1yLkG0OFI6KM7:TR?=M4m1e3NCVkeHUh?=
SHP-77NEPZeFhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MnnmTWM2OD1yLkG0OFczKM7:TR?=M3nDOXNCVkeHUh?=
U-266M1XIdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7Mn\FTWM2OD1yLkG0OFgh|ryPM13WO3NCVkeHUh?=
GI-1NUflSWw5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MnfWTWM2OD1yLkG0O|czKM7:TR?=M1n6d3NCVkeHUh?=
NCI-H1522NWDsdYN[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MV3JR|UxRTBwMUS3PFch|ryPNIXQd5VUSU6JRWK=
647-VMlf3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M4jsVmlEPTB;MD6xOFk1OiEQvF2=MYjTRW5ITVJ?
HCT-116NGW1b3hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M2HIOGlEPTB;MD6xOVE3QSEQvF2=MX3TRW5ITVJ?
NCI-H2081NH7JdZRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MYjJR|UxRTBwMUWyNVgh|ryPNWi2dYp7W0GQR1XS
THP-1M2XYS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7MkHITWM2OD1yLkG1N|M{KM7:TR?=MlfWV2FPT0WU
LU-165NVrhTFI1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=Ml3pTWM2OD1yLkG1OFE{KM7:TR?=M{fyZ3NCVkeHUh?=
RCM-1NGPUdpNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MmLzTWM2OD1yLkG1Olgh|ryPNE\sVlRUSU6JRWK=
COR-L279MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NWi0XZBRUUN3ME2wMlE2QDN4IN88US=>M{LEWXNCVkeHUh?=
SK-NEP-1MlTxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NXTte2h4UUN3ME2wMlE2QDl7IN88US=>M{[ySXNCVkeHUh?=
KLENV7Cb2MyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NW\JRmhmUUN3ME2wMlE3OTZ7IN88US=>MYnTRW5ITVJ?
NCI-H2170MmTLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NHnpeZBKSzVyPUCuNVY{ODRizszNMnz0V2FPT0WU
TGWM1\ydWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MX\JR|UxRTBwMU[0O|Eh|ryPMYnTRW5ITVJ?
CAL-72MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NF7OR2lKSzVyPUCuNVY2QSEQvF2=NYjmSWtLW0GQR1XS
K052MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?Ml7NTWM2OD1yLkG3NFYyKM7:TR?=MonzV2FPT0WU
COR-L88M2DXfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MYjJR|UxRTBwMUexNVQh|ryPMl\vV2FPT0WU
HSC-4M1qxVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NH\Rd3FKSzVyPUCuNVcyPiEQvF2=MlrGV2FPT0WU
GOTOM3;zZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7Mm\jTWM2OD1yLkG3NlQ3KM7:TR?=NYXDNFlGW0GQR1XS
MEG-01M{TGSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NXSwO3R6UUN3ME2wMlE4OjV5IN88US=>MX7TRW5ITVJ?
MDA-MB-134-VIMkDES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MWnJR|UxRTBwMUezOlch|ryPNILH[XhUSU6JRWK=
NCI-H596MkX3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NXq3SZlJUUN3ME2wMlE4OzhizszNNHzxPFhUSU6JRWK=
EW-3MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MorjTWM2OD1yLkG3OFg3KM7:TR?=NFPMWIVUSU6JRWK=
NCI-H1573NFLWRZlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M1q0UWlEPTB;MD6xO|Y4QCEQvF2=M{XGeHNCVkeHUh?=
SKG-IIIaM2nnN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7NUfneHNTUUN3ME2wMlE4QDB5IN88US=>NHrN[2NUSU6JRWK=
SK-N-DZMWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M1npUGlEPTB;MD6xO|g5OyEQvF2=MmnIV2FPT0WU
EGI-1MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NF\VZnBKSzVyPUCuNVc6PyEQvF2=M4WyRXNCVkeHUh?=
COLO-320-HSRM4PROWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M{C1bmlEPTB;MD6xPFQ6OyEQvF2=NHfsO49USU6JRWK=
DOHH-2MojyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M4TjR2lEPTB;MD6xPFU3QSEQvF2=M3z5e3NCVkeHUh?=
MS-1Mm\US5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MlXyTWM2OD1yLkG4OkDPxE1?M1XCfHNCVkeHUh?=
NCI-H2171Mk\wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NF:3b5ZKSzVyPUCuNVg3PDlizszNMojkV2FPT0WU
NCI-H526NXS2SVVKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NXfJZ4NZUUN3ME2wMlE5Pjl4IN88US=>NEDBTZRUSU6JRWK=
MDA-MB-415NITFUXBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NWTSWFhlUUN3ME2wMlE6PzR6IN88US=>M3HaPHNCVkeHUh?=
ECC4MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NVfR[mxkUUN3ME2wMlE6QDZ|IN88US=>M{HSXnNCVkeHUh?=
C2BBe1MoLpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NUjFc4NxUUN3ME2wMlE6QDl|IN88US=>NGjQVIdUSU6JRWK=
TE-11NFzZV25Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MVHJR|UxRTBwMUm5O|Uh|ryPMknnV2FPT0WU
LU-65NWLPRWc6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NV7BVIdOUUN3ME2wMlIxOjFzIN88US=>M3XRenNCVkeHUh?=
MKN45NEjWbIVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NULW[YN5UUN3ME2wMlIxPjRizszNMU\TRW5ITVJ?
TGBC1TKBNEnJUYNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NHTZeHpKSzVyPUCuNlA6QTdizszNNIixcZRUSU6JRWK=
NCI-H2196NGKxbnFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MXnJR|UxRTBwMkG3OFch|ryPNXvydoh6W0GQR1XS
M14MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MojPTWM2OD1yLkKxPFA{KM7:TR?=MnHpV2FPT0WU
NCI-H1436M4DvNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MWLJR|UxRTBwMkG4NlYh|ryPMYPTRW5ITVJ?
EB-3M{HHSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NYC3XmNTUUN3ME2wMlIzOzd4IN88US=>NFfKZVJUSU6JRWK=
HTNUfTU|l1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M37MNmlEPTB;MD6yNlU3PiEQvF2=NITufXpUSU6JRWK=
A3-KAWM4rWdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NELteoRKSzVyPUCuNlI4ODhizszNNIL4[VVUSU6JRWK=
DBM3\LeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NHLnT21KSzVyPUCuNlI5PjVizszNNHPnVmtUSU6JRWK=
KARPAS-299MoXPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MkfpTWM2OD1yLkKyPVk1KM7:TR?=MY\TRW5ITVJ?
IM-9NULwVFMyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M3XrWWlEPTB;MD6yN|Q4PiEQvF2=Ml7zV2FPT0WU
NCI-H838MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M4LzbWlEPTB;MD6yN|cyPCEQvF2=MnXNV2FPT0WU
NB10NXq1UWJVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MkPuTWM2OD1yLkKzO|MyKM7:TR?=M4PtbXNCVkeHUh?=
NCI-H2141M1nrR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7M{jrRWlEPTB;MD6yN|g1OSEQvF2=NXjsS3QxW0GQR1XS
LB647-SCLCNUW3dW1OT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MUjJR|UxRTBwMkSwNVQh|ryPMne2V2FPT0WU
NCI-H23MnzuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?Mlq4TWM2OD1yLkK0NFU6KM7:TR?=M1G0N3NCVkeHUh?=
MN-60MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NX:0[WZQUUN3ME2wMlI1OjN7IN88US=>MljRV2FPT0WU
CAL-148M1HydGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NFHjcFFKSzVyPUCuNlQzQDJizszNMV\TRW5ITVJ?
EFE-184NVfyepVYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MmjjTWM2OD1yLkK0OVk4KM7:TR?=NWXU[HlsW0GQR1XS
TE-6NGTPfXhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=Ml7JTWM2OD1yLkK0OlEzKM7:TR?=NUH1THIzW0GQR1XS
SN12CM4nn[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NVzYXJhOUUN3ME2wMlI1Pjl2IN88US=>MX7TRW5ITVJ?
CAKI-1MnuyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M{n2UWlEPTB;MD6yOVA5PiEQvF2=NHHXV5pUSU6JRWK=
MHH-NB-11M1rOcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NGnFTHBKSzVyPUCuNlU{PSEQvF2=NV\xU2F6W0GQR1XS
DOKMUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NILUWJhKSzVyPUCuNlU6OyEQvF2=NGP3V|BUSU6JRWK=
RajiM{W1[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NFz3Z3pKSzVyPUCuNlY3ODNizszNNFzCbYlUSU6JRWK=
OAW-28NYnKW2xvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MVfJR|UxRTBwMk[2O|ch|ryPNY\iRlNPW0GQR1XS
P30-OHKNVf2NndmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MnH5TWM2OD1yLkK2PVA2KM7:TR?=MVHTRW5ITVJ?
NCI-H69MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MojRTWM2OD1yLkK3NlAyKM7:TR?=MX;TRW5ITVJ?
SK-N-ASNHrLUJNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MXzJR|UxRTBwMkeyNkDPxE1?NHqwVmxUSU6JRWK=
BE-13MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MmLGTWM2OD1yLkK3NlQ6KM7:TR?=MX\TRW5ITVJ?
NCI-H1618MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NV;2eHhQUUN3ME2wMlI4PTFizszNNILXe|dUSU6JRWK=
NCI-SNU-5NHvYZ|FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M{HINGlEPTB;MD6yO|YyOyEQvF2=M37RSXNCVkeHUh?=
NCI-H1694MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MVTJR|UxRTBwMke3N|Mh|ryPM3HNXXNCVkeHUh?=
RLM3vjSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NIThb2ZKSzVyPUCuNlgyPzRizszNNGmzXHVUSU6JRWK=
SW684NU[4cY1YT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NWnGOZRGUUN3ME2wMlI5Ozh|IN88US=>MYnTRW5ITVJ?
EW-24MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MU\JR|UxRTBwMki4NUDPxE1?NGnXdG1USU6JRWK=
NCI-H510AMVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M13vdGlEPTB;MD6yPVMxPCEQvF2=NGnNPXlUSU6JRWK=
Mo-TNVS1b3U5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M2rXfWlEPTB;MD6yPVM{OSEQvF2=MlT0V2FPT0WU
LB373-MEL-DNFXUVldIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M3fNdWlEPTB;MD6yPVQ{OSEQvF2=NELVVmNUSU6JRWK=
NCI-H28MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MWjJR|UxRTBwMkm4N|ch|ryPMnrrV2FPT0WU
NCI-H446NFTY[Y9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M1HGN2lEPTB;MD6yPVkzOSEQvF2=M372WXNCVkeHUh?=
L-540MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NEH1UWRKSzVyPUCuN|AxQDlizszNMXPTRW5ITVJ?
MKN7MlTrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NXLWWY93UUN3ME2wMlMxPjN7IN88US=>NGnIO3BUSU6JRWK=
OPM-2M1XS[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NYn0d4VQUUN3ME2wMlMyODZ2IN88US=>MWDTRW5ITVJ?
BT-20NH7RRoJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NFjyTW9KSzVyPUCuN|ExQTlizszNMVvTRW5ITVJ?
KP-N-YNMXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M4PGbmlEPTB;MD6zNVEyQCEQvF2=MXLTRW5ITVJ?
MDA-MB-175-VIINYDKN3NbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MkTQTWM2OD1yLkOyN|Q5KM7:TR?=M1LHcnNCVkeHUh?=
EFM-19MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MkHhTWM2OD1yLkOzNVMzKM7:TR?=NGPKfXBUSU6JRWK=
COLO-678NELkfoZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NYDHSmlOUUN3ME2wMlM{Ozh7IN88US=>M3rEWHNCVkeHUh?=
COLO-829MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M1nnbmlEPTB;MD6zOFQ2OiEQvF2=M1zoVXNCVkeHUh?=
A704NVXyfXlNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NXjQTVJRUUN3ME2wMlM1QTJ|IN88US=>M4\KUnNCVkeHUh?=
NCI-H719NUG2cZduT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MWDJR|UxRTBwM{WxNlQh|ryPMkPIV2FPT0WU
MFE-280Ml3wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NIHh[WZKSzVyPUCuN|U4OTVizszNM{XK[3NCVkeHUh?=
DMS-114M1LJXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7Mn\xTWM2OD1yLkO2NVIh|ryPNFSzRlFUSU6JRWK=
RMG-INXXjfZByT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NV;CboRWUUN3ME2wMlM3PjlzIN88US=>M4PweHNCVkeHUh?=
SK-N-FIMXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NFqxbmZKSzVyPUCuN|c3OzdizszNNYTZ[3VmW0GQR1XS
LB2518-MELNEWyU45Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NUW4eYdKUUN3ME2wMlQxQDd{IN88US=>MUjTRW5ITVJ?
IST-MES1NITxbJRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M4DmPGlEPTB;MD60NVEh|ryPM2PmfHNCVkeHUh?=
HPAF-IINIfUOZJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NY\JfWpFUUN3ME2wMlQyOTF5IN88US=>M2TpfXNCVkeHUh?=
NCI-H1882NHrMZXZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MX\JR|UxRTBwNEG3PFQh|ryPNGftU3lUSU6JRWK=
JVM-2MkKyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MWnJR|UxRTBwNES0NFEh|ryPMlrIV2FPT0WU
T47DM2[3T2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7MmK0TWM2OD1yLkS0OVI5KM7:TR?=NFLs[YZUSU6JRWK=
MHH-CALL-2M4TEc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7MXLJR|UxRTBwNES4N{DPxE1?MmrJV2FPT0WU
NCI-H716MlntS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MXLJR|UxRTBwNES4OFgh|ryPMWHTRW5ITVJ?
NEC8MnXVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MlvqTWM2OD1yLkS1NVQ2KM7:TR?=MoXRV2FPT0WU
UACC-812MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MkHmTWM2OD1yLkS2O|c3KM7:TR?=NHnsR2ZUSU6JRWK=
D-502MGMYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M3\hcmlEPTB;MD60PFA{KM7:TR?=NEDXVXlUSU6JRWK=
CaR-1NXXZXFZbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NIH2[m9KSzVyPUCuOVA{PjdizszNNFPEXXpUSU6JRWK=
LU-139MoPvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M{[ycWlEPTB;MD61NVQ2PyEQvF2=MlewV2FPT0WU
RPMI-8402M4HLRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M{DqdWlEPTB;MD61NlIxPyEQvF2=NFvSWGVUSU6JRWK=
SW1088M4fY[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M3TLT2lEPTB;MD61N|g3QSEQvF2=MVHTRW5ITVJ?
JVM-3MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MVXJR|UxRTBwNUSxNVch|ryPM3XrN3NCVkeHUh?=
YAPCMUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NIXnSFRKSzVyPUCuOVUzOTFizszNM{XBZ3NCVkeHUh?=
KG-1NYDsbIRzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NE\v[|BKSzVyPUCuOVU6QDRizszNMVnTRW5ITVJ?
C32MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M1LZW2lEPTB;MD61O|MyOyEQvF2=NYXCbZR6W0GQR1XS
IST-SL1M{XHcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MmH6TWM2OD1yLk[wOFM2KM7:TR?=NFnGeWNUSU6JRWK=
NCI-H2126NUTxZ5ZHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M1jPbGlEPTB;MD62N|E2OiEQvF2=MoD5V2FPT0WU
HCC1954M2fZVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NGPlTlhKSzVyPUCuOlQ4OjZizszNMmnNV2FPT0WU
WM-115MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NInkZlNKSzVyPUCuOlUxQTJizszNNUDRc41KW0GQR1XS
NB6M1Ptd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7MnrZTWM2OD1yLk[3N|M2KM7:TR?=M4KxTnNCVkeHUh?=
TYK-nuMmLDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NITFd4lKSzVyPUCuOlc6PTJizszNMn;OV2FPT0WU
KY821Mkj1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NVPoUnJNUUN3ME2wMlcxOjJ7IN88US=>MV7TRW5ITVJ?
SIMANYnZXXdnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NXjLVol7UUN3ME2wMlcyPzF7IN88US=>MYjTRW5ITVJ?
RCC10RGBMkTRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MlHKTWM2OD1yLkexPVE5KM7:TR?=NUC1UGszW0GQR1XS
LN-405M{Xve2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7NGH4[lNKSzVyPUCuO|Q{PiEQvF2=NFLpS|JUSU6JRWK=
NCI-H1155Ml:zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NUTJc2w5UUN3ME2wMlc1QDZ6IN88US=>MVPTRW5ITVJ?
SCLC-21HMnrxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NETw[XFKSzVyPUCuO|Y6ODNizszNNHnIRWlUSU6JRWK=
DMS-79MlTVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MUjJR|UxRTBwN{e4OFUh|ryPMmDDV2FPT0WU
EC-GI-10M4LyWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M4T1SGlEPTB;MD63O|k4PSEQvF2=M2\5WXNCVkeHUh?=
KNS-42NFjwNY1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NFS0dWpKSzVyPUCuO|g5OzFizszNMn\pV2FPT0WU
SNU-475MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MnPHTWM2OD1yLke5NlAzKM7:TR?=NWPVTINYW0GQR1XS
SF539NH\5SIlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NGm1bVlKSzVyPUCuO|k6OjVizszNNEe1e2tUSU6JRWK=
SW1417NHfCTlhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NHnJWXBKSzVyPUCuPFE{OzlizszNNHrmcJhUSU6JRWK=
ATN-1MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M2j2PWlEPTB;MD64OVEyPSEQvF2=M3zWcXNCVkeHUh?=
PLC-PRF-5MnnDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M3nq[mlEPTB;MD64PFQ4PSEQvF2=M1\Sb3NCVkeHUh?=
HT-3NYHicZJ1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NX7jbHZxUUN3ME2wMlg6PDJizszNMl\DV2FPT0WU
MDA-MB-453MoT4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MlyyTWM2OD1yLkmwN|A1KM7:TR?=NX61RlB7W0GQR1XS
HAL-01M4rCPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M4XoWGlEPTB;MD65PVM4QSEQvF2=MYnTRW5ITVJ?
NCI-H1993NXHU[YhLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MonITWM2OD1zLkC0OlU4KM7:TR?=M4HHb3NCVkeHUh?=
NCI-H2227MnjhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MlTNTWM2OD1zLkC0PVgyKM7:TR?=MUXTRW5ITVJ?
LP-1NX\0b2VMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MWDJR|UxRTFwME[5N{DPxE1?NUnuSVB2W0GQR1XS
P31-FUJMVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M3\nemlEPTB;MT6xNFc3PiEQvF2=MoHrV2FPT0WU
NCI-H64M1Ow[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7MmXQTWM2OD1zLkG1OFIh|ryPMmDhV2FPT0WU
SW1463MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M2HVWGlEPTB;MT6xPFM1QSEQvF2=MVTTRW5ITVJ?
SK-MEL-1NWHXenhWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MX;JR|UxRTFwMkC1PVUh|ryPNWPpW5ROW0GQR1XS
TALL-1NHTZfGlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NVLmco9mUUN3ME2xMlI2OTZ3IN88US=>NX7GNXdSW0GQR1XS
RO82-W-1NHj3WHFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NHz0c2FKSzVyPUGuN|M{OzlizszNNI\3cnZUSU6JRWK=
NCI-H1581MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NFLPWpNKSzVyPUGuN|U3QDdizszNNUjkeHVVW0GQR1XS
NCI-H748NEDuWHlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NX3wWXJSUUN3ME2xMlM2PzN6IN88US=>M{PKU3NCVkeHUh?=
HCC1187MlTNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NWLPbFE3UUN3ME2xMlU2PTJ{IN88US=>MWTTRW5ITVJ?
EoL-1-cellNGHj[olIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MlnlTWM2OD1zLkW4PFg6KM7:TR?=M{nJ[nNCVkeHUh?=
HuO-3N1M4LxTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MVTJR|UxRTFwOEO0NVIh|ryPNVKzNHFrW0GQR1XS
NCI-H1793MlnjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NFjITZlKSzVyPUGuPFc2QTNizszNNGfGfHFUSU6JRWK=
Caov-3M3Hne2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7NFf5WFBKSzVyPUKuNFA3OjVizszNNHf3UZFUSU6JRWK=
JARMWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NYLhRnUyUUN3ME2yMlA4QTJizszNM2jT[HNCVkeHUh?=
SK-MEL-28M3u1bGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MYjJR|UxRTJwMUiwPVgh|ryPMmLxV2FPT0WU
EM-2M3;4b2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7MYHJR|UxRTJwMkCyPVMh|ryPNFHVTYlUSU6JRWK=
MewoMl;BS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NW\FUpZIUUN3ME2yMlIzOjZ3IN88US=>MXHTRW5ITVJ?
NCI-H720MofrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MkPITWM2OD1{LkK2OVg2KM7:TR?=MV\TRW5ITVJ?
CAL-54NXHrS3JLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M4O5WWlEPTB;Mj6yOlc6PSEQvF2=MXzTRW5ITVJ?
MC116M4Tpbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NGqwUHFKSzVyPUKuN|Y{QTdizszNMXzTRW5ITVJ?
DG-75NWH6OHAzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NETUSZZKSzVyPUKuOFg2PzZizszNNUjNTGd6W0GQR1XS
HCC1143MmO3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NU\GVnZjUUN3ME2yMlUxPjV6IN88US=>NG\rUJBUSU6JRWK=
FTC-133Ml\RS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MXvJR|UxRTJwNUO2PFkh|ryPNX7FVJZ3W0GQR1XS
AsPC-1M2q0VWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MnPRTWM2OD1{LkWzPVI6KM7:TR?=NHLsb3pUSU6JRWK=
NCI-H889MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M{fYNGlEPTB;Mj61OlcxPiEQvF2=MYDTRW5ITVJ?
HT55MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MnqyTWM2OD1{Lk[yNFE6KM7:TR?=M1noeHNCVkeHUh?=
UMC-11Mmr1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MY\JR|UxRTJwN{i3NVUh|ryPNHnQSmZUSU6JRWK=
P12-ICHIKAWANGLUb5VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MkjzTWM2OD1{LkiyNFQ3KM7:TR?=NFTVdIRUSU6JRWK=
HCC1395MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MY\JR|UxRTJwOUi2NFIh|ryPMXPTRW5ITVJ?
D-283MEDNEe3fHpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NV;GUo56UUN3ME2zMlE5QTN5IN88US=>M2H3V3NCVkeHUh?=
COLO-800NInhcJdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NHzJO3lKSzVyPUOuN|M5QTdizszNNEnEbI1USU6JRWK=
MFM-223NIfRfY1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NHPodFFKSzVyPUOuN|YxQTdizszNNXrZXG1oW0GQR1XS
TE-5NEm4N5pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=Mny1TWM2OD12LkW2NVQ4KM7:TR?=MUTTRW5ITVJ?
NCI-H209NGnCO3dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MnjRTWM2OD12Lke4OVczKM7:TR?=MYDTRW5ITVJ?
SiHaNX3DXpBlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MWHJR|UxRTRwOUWyNFMh|ryPMnHpV2FPT0WU
NCI-H1395Mlu2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NYLk[pB[UUN3ME21MlExPjN|IN88US=>NEPuPHNUSU6JRWK=
A498M3nTTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M2HJZ2lEPTB;NT6yNVI2OSEQvF2=M2jaZ3NCVkeHUh?=
ES5NXfocWptT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NIT2RVNKSzVyPUWuOlEyPzhizszNNWGzU5BTW0GQR1XS
MDA-MB-157MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MVPJR|UxRTVwNk[0OFMh|ryPMXzTRW5ITVJ?
NCI-H1623NH6wcYlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M2fJc2lEPTB;NT64N|U2PiEQvF2=NEPT[oRUSU6JRWK=
RPMI-8866NFXufYRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NXPZTIdIUUN3ME21Mlg1Pzl{IN88US=>MUHTRW5ITVJ?
LC-1FMUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MnrQTWM2OD14LkC5NlkyKM7:TR?=M3TrbnNCVkeHUh?=
TCCSUPM{LSTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NHPaUJpKSzVyPU[uOlA{PDlizszNNYTne4RMW0GQR1XS
TTMULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MUPJR|UxRThwM{OwNFkh|ryPMmDHV2FPT0WU
NCI-H1838M2PzT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7Mk\4TWM2OD16LkWxO|MyKM7:TR?=MlnmV2FPT0WU
NCI-H322MNEXadmZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MknJTWM2OD17LkG2NlgyKM7:TR?=MX7TRW5ITVJ?
NCI-H187NFLVeVhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M{H1TGlEPTB;OT61NVg{PSEQvF2=NHnFO2dUSU6JRWK=
SBC-1MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NV\xW|FZUUN3ME25Mlk{PjV4IN88US=>MnG4V2FPT0WU
SCC-3NYfX[FZuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NYnaUXQ5UUN3ME2xNE42Pjd7IN88US=>Ml3zV2FPT0WU
SW948Ml70S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M{PvWWlEPTB;MUCuO|UyOSEQvF2=NH\aeHdUSU6JRWK=
CPC-NM4DoVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7Mmi1TWM2OD1zMT6wNFch|ryPMn;PV2FPT0WU
TGBC24TKBMVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M4rJeGlEPTB;MUOuOVI6KM7:TR?=MlrIV2FPT0WU
NCI-H2452MoPhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MlS4TWM2OD1zND63N{DPxE1?NVL3R3Y1W0GQR1XS
Hs-578-TNHfPSY1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M1XkOWlEPTB;MUiuOVc2QSEQvF2=NYHiZXcyW0GQR1XS
DV-90NYHBbZdnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NIfN[oFKSzVyPUG4Mlk6PDVizszNNGjCOWhUSU6JRWK=
NCI-H1563M4PHSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M1fhU2lEPTB;MUmuO|g5QCEQvF2=NVzZelNsW0GQR1XS
SW780MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MUDJR|UxRTJzLkGzNVgh|ryPMWnTRW5ITVJ?
NCI-H345MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M{Ky[WlEPTB;MkGuPFc4QSEQvF2=M3izXXNCVkeHUh?=
LB771-HNCNFf6bIFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NXezPJlJUUN3ME2yNk41QDF|IN88US=>NWT3VmtHW0GQR1XS
RT4MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M3;J[mlEPTB;MkOuN|I5OiEQvF2=MkW2V2FPT0WU
NCI-H82M{D3Z2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7NIn2WVFKSzVyPUKzMlU2OjZizszNMnnSV2FPT0WU
NCI-H524NYrJWG1YT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MYPJR|UxRTJ2LkO4NVIh|ryPM{X1R3NCVkeHUh?=
SNU-C1MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NVi4Uot2UUN3ME2yOE46OTB3IN88US=>NUXTbIxCW0GQR1XS
NCI-SNU-16M2ThSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M37zN2lEPTB;NEiuN|E1OiEQvF2=NWS3ZXY3W0GQR1XS

... Click to View More Cell Line Experimental Data

In vivo Treatment with NVP-AUY922 causes a robust antitumor response and inhibits p-Akt and VEGF expression in an HSC-2 xenograft model. [2] In BT474, NVP-AUY922 shows complete loss of ERBB2 and substantial depletion of ERα, in addition to reductions in CDK4 and phospho-ERK1/2. [3]
Features

Protocol(Only for Reference)

Kinase Assay: [3]

Kinase assay NVP-AUY922 is dissolved in DMSO at a concentration of 10 mM. NVP-AUY922 is assessed against HSP90α, HSP90β, GRP94, TRAP-1, HSP72, and topoisomerase II. Profiling against a panel of kinases has been carried out and screening against a panel of additional enzymes and receptors is performed at Cerep.

Cell Assay: [1]

Cell lines Human gastric cancer cells NCI-N87
Concentrations 1 μM
Incubation Time 3 days
Method Human gastric cancer cells NCI-N87 (5-7 ×103 in 50 μL/well) are seeded in 96-well plates and incubated at 37 °C for 24 hours, followed by NVP-AUY922 treatment for 1-3 days at 37 °C. After treatment, the cells are assayed by MTT method and analyzed by microplate reader.

Animal Study: [3]

Animal Models Female NCr athymic mice bearing WM266.4 human melanoma xenografts
Formulation In DMSO and diluted in sterile saline/Tween 20
Dosages 50 mg/kg
Administration Administered via i.v. or i.p.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

SpeciesMouseRatRabbitGuinea pigHamsterDog
Weight (kg)0.020.151.80.40.0810
Body Surface Area (m2)0.0070.0250.150.050.020.5
Km factor36128520
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Rat dose (mg/kg) = mouse dose (22.4 mg/kg) ×  mouse Km(3)  = 11.2 mg/kg
rat Km(6)
1

References

[1] Lee KH, et al. Cancer Sci, 2011, 102(7), 1388-1395.

[2] Okui T, et al. Anticancer Res, 2011, 31(4), 1197-1204.

view more

Clinical Trial Information( data from http://clinicaltrials.gov, updated on 2016-07-30)

NCT Number Recruitment Conditions Sponsor
/Collaborators
Start Date Phases
NCT01784640 Active, not recruiting Recurrent Non-small Cell Lung Cancer|Squamous Cell Lung Cancer|Stage IV Non-small Cell Lung Cancer Jonsson Comprehensive Cancer Center|National Cancer Insti  ...more Jonsson Comprehensive Cancer Center|National Cancer Institute (NCI) January 2014 Phase 1
NCT01922583 Recruiting Non-small Cell Lung Cancer (NSCLC) National Taiwan University Hospital January 2014 Phase 2
NCT01854034 Recruiting Non Small Cell Lung Cancer Massachusetts General Hospital July 2013 Phase 2
NCT01772797 Completed Anaplastic Lymphoma Kinase (ALK)|Non-small Cell Lung Cancer Novartis Pharmaceuticals|Novartis June 2013 Phase 1
NCT01752400 Active, not recruiting Non Small Cell Lung Cancer Massachusetts General Hospital January 2013 Phase 2

view more

Chemical Information

Download Luminespib (AUY-922, NVP-AUY922) SDF
Molecular Weight (MW) 465.54
Formula

C26H31N3O5

CAS No. 747412-49-3
Storage 3 years -20℃powder
6 months-80℃in solvent
Synonyms VER-52296
Solubility (25°C) * In vitro DMSO 93 mg/mL warming (199.76 mM)
Ethanol 31 mg/mL (66.58 mM)
Water <1 mg/mL (<1 mM)
In vivo 1% DMSO+30% polyethylene glycol+1% Tween 80 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Chemical Name 5-(2,4-dihydroxy-5-isopropylphenyl)-N-ethyl-4-(4-(morpholinomethyl)phenyl)isoxazole-3-carboxamide

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

* Indicates a Required Field

Related HSP (e.g. HSP90) Products

  • PU-H71

    PU-H71 is a potent and selective inhibitor of HSP90 with IC50 of 51 nM. Phase 1.

  • KNK437

    KNK437 is a pan-HSP inhibitor, which inhibits the synthesis of inducible HSPs, including HSP105, HSP72, and HSP40.

  • VER155008

    VER-155008 is a potent Hsp70 family inhibitor with IC50 of 0.5 μM, 2.6 μM, and 2.6 μM in cell-free assays for HSP70, HSC70, and GRP78, respectively, >100-fold selectivity over HSP90.

  • 17-AAG (Tanespimycin)

    17-AAG (Tanespimycin) is a potent HSP90 inhibitor with IC50 of 5 nM in a cell-free assay, having a 100-fold higher binding affinity for HSP90 derived from tumour cells than HSP90 from normal cells. Phase 2.

    Features:Displays very low toxicity toward normal cells.

  • Ganetespib (STA-9090)

    Ganetespib (STA-9090) is an HSP90 inhibitor with IC50 of 4 nM in OSA 8 cells, induces apoptosis of OSA cells while normal osteoblasts are not affected; active metabolite of STA-1474. Phase 3.

  • 17-DMAG (Alvespimycin) HCl

    17-DMAG (Alvespimycin) HCl is a potent HSP90 inhibitor with IC50 of 62 nM in a cell-free assay. Phase 2.

    Features:A synthetic derivative Geldanamycin, with lower hepatotoxicity than parent antibiotic & higher potency and bioavailability than the similar derivative 17-AAG.

  • Geldanamycin

    Geldanamycin is a natural existing HSP90 inhibitor with Kd of 1.2 μM, specifically disrupts glucocorticoid receptor (GR)/HSP association.

  • HSP990 (NVP-HSP990)

    NVP-HSP990 (HSP990) is a novel, potent and selective HSP90 inhibitor for HSP90α/β with IC50 of 0.6 nM/0.8 nM.

    Features:NVP-HSP990 is an orally available HSP90 inhibitor and is structurally distinct from other clinical HSP90 inhibitors.

  • Elesclomol (STA-4783)

    Elesclomol (STA-4783) is a novel potent oxidative stress inducer that elicits pro-apoptosis events among tumor cells. Phase 3.

  • Onalespib (AT13387)

    Onalespib (AT13387) is a selective potent Hsp90 inhibitor with IC50 of 18 nM in A375 cells, displays a long duration of anti-tumor activity. Phase 2.

Recently Viewed Items

Tags: buy Luminespib (AUY-922, NVP-AUY922) | Luminespib (AUY-922, NVP-AUY922) supplier | purchase Luminespib (AUY-922, NVP-AUY922) | Luminespib (AUY-922, NVP-AUY922) cost | Luminespib (AUY-922, NVP-AUY922) manufacturer | order Luminespib (AUY-922, NVP-AUY922) | Luminespib (AUY-922, NVP-AUY922) distributor
×
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
Contact Us