Luminespib (AUY-922, NVP-AUY922)

Catalog No.S1069 Synonyms: VER-52296

Luminespib (AUY-922, NVP-AUY922) Chemical Structure

Molecular Weight(MW): 465.54

Luminespib (AUY-922, NVP-AUY922) is a highly potent HSP90 inhibitor for HSP90α/β with IC50 of 13 nM /21 nM in cell-free assays, weaker potency against the HSP90 family members GRP94 and TRAP-1, exhibits the tightest binding of any small-molecule HSP90 ligand. Phase 2.

Size Price Stock Quantity  
In DMSO USD 320 In stock
USD 160 In stock
USD 270 In stock
USD 470 In stock

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3 Customer Reviews

  • U2OS_exo cells were incubated with AUY922 for 20 h at the indicated concentrations before stimulation with TNFα (30 ng/mL) for 30 min and immunostaining to detect NF-κB (p65). DMSO 1%, cells stimulated by TNFα in the absence of AUY922. Representative pictures used to quantify nuclear and cytoplasmic localization of NF-κB.

    Proc Natl Acad Sci USA, 2014, 111(15): E1528–37 . Luminespib (AUY-922, NVP-AUY922) purchased from Selleck.

    J Biol Chem 2013 288(23), 16308-20. Luminespib (AUY-922, NVP-AUY922) purchased from Selleck.

  • Western blots show the molecular signature of HSP90 inhibition by NVP-AUY922  (ie, induction of HSP72 and depletion of client proteins such as ERBB2, CRAF and CDK4) in BT474 breast cancer cell line. GAPDH was used as loading control.

     

     

    2011 Dr. Swee Sharp and Professor Paul Workman from Cancer Research UK. Luminespib (AUY-922, NVP-AUY922) purchased from Selleck.

Purity & Quality Control

Choose Selective HSP (e.g. HSP90) Inhibitors

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Notes:

2. For more details, such as half maximal inhibitory concentrations (IC50s) and working concentrations of each inhibitor, please click on the link of the inhibitor of interest.
3. "+" indicates inhibitory effect. Increased inhibition is marked by a higher "+" designation.
4. Orange "√" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

Biological Activity

Description Luminespib (AUY-922, NVP-AUY922) is a highly potent HSP90 inhibitor for HSP90α/β with IC50 of 13 nM /21 nM in cell-free assays, weaker potency against the HSP90 family members GRP94 and TRAP-1, exhibits the tightest binding of any small-molecule HSP90 ligand. Phase 2.
Targets
HSP90α [1]
(Cell-free assay)
HSP90β [1]
(Cell-free assay)
13 nM 21 nM
In vitro

NVP-AUY922 inhibits proliferation of various human cancer cell lines in vitro, with an average GI50 of 9 nM. [1] The IC50 values of NVP-AUY922 fall in the range of 2 to 40 nM in these gastric cancer cell lines. IC50 value for the BEAS-2B cells is 28.49 nM. Treatment with NVP-AUY922 does not influence the expression of HSP90, but expression of HSP70 gets elevated by NVP-AUY922 treatment. NVP-AUY922 increases the binding of HSP70 to HSP90. NVP-AUY922 causes p23 dissociation from the HSP90 complex and can then recruit HSP70 to the HSP90 complex. [1] After the treatment with NVP-AUY922, expression of receptor tyrosine kinases including VEGFR1, 2, 3 and PDGFRɑ is decreased. A decrease is also noticed in the expression of Akt and phospho-Akt. Meanwhile, treatment with NVP-AUY922 causes decreased expression of HER-2 in NCI-N87 cells. NVP-AUY922 treatment results in binding of HSP90 to client proteins and setting them up as targets for degradation by the proteasome. NVP-AUY922 can influence cell growth by affecting multiple signaling pathways. In addition, treatment with the proteasome inhibitor, MG132, restores expression of thymidylate synthase, which is decreased by NVP-AUY922. NVP-AUY922 increases the expression of cleaved caspase-3 leading to apoptosis in HSC-2 cells.[1]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
CMK MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWnafpE3UUN3ME2wMlAxODF{NTFOwG0> NI\5fnhUSU6JRWK=
MV-4-11 NEDnOFNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXTpbHdqUUN3ME2wMlAxODV3ODFOwG0> M3r0bnNCVkeHUh?=
NALM-6 NVT2N3AyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3XZ[2lEPTB;MD6wNFA5PDJizszN MnrVV2FPT0WU
HOS MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVyxSnp7UUN3ME2wMlAxOTN6IN88US=> MoG0V2FPT0WU
HT-144 M4jG[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVPVO3h5UUN3ME2wMlAxOTV3IN88US=> NHf3UGJUSU6JRWK=
SW1710 M2jnN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{\tTmlEPTB;MD6wNFE5PiEQvF2= NGLxZ5FUSU6JRWK=
TE-8 MnLRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1KxV2lEPTB;MD6wNFI{PyEQvF2= NIjhUYxUSU6JRWK=
ES1 MlrDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnLtTWM2OD1yLkCwNlY3KM7:TR?= Mlr4V2FPT0WU
CCF-STTG1 NWLGV2l[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXLJR|UxRTBwMECyPVch|ryP NHnze25USU6JRWK=
PSN1 M{noWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWjJR|UxRTBwMECzNVgh|ryP NVLkWYRrW0GQR1XS
CAL-51 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHXVU4dKSzVyPUCuNFA{OjVizszN M3LrdnNCVkeHUh?=
MCF7 NVrjPItPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXiy[mpXUUN3ME2wMlAxOzN3IN88US=> NV\Sd4k2W0GQR1XS
SK-HEP-1 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFS0OVhKSzVyPUCuNFA{OzZizszN NHr0bmlUSU6JRWK=
LCLC-103H NVXHUpZST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHLQXXNKSzVyPUCuNFA1OyEQvF2= MUfTRW5ITVJ?
HMV-II MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1fSd2lEPTB;MD6wNFQ1QSEQvF2= MWLTRW5ITVJ?
MES-SA MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXewTlVEUUN3ME2wMlAxPDV{IN88US=> M3HVVXNCVkeHUh?=
SK-LMS-1 M1\Kc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIG3PWtKSzVyPUCuNFA1PThizszN NYr0[WJ{W0GQR1XS
639-V NV;uUmt3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1TaOWlEPTB;MD6wNFQ5PSEQvF2= NF3TbINUSU6JRWK=
SIG-M5 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml:2TWM2OD1yLkCwOFg6KM7:TR?= NHfDTWpUSU6JRWK=
LOUCY M1H0eWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWDyOJlvUUN3ME2wMlAxPTB3IN88US=> NHn4fYhUSU6JRWK=
HSC-2 NUTleI5qT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF;pcpRKSzVyPUCuNFA2OThizszN NITlNlRUSU6JRWK=
EW-13 NH\kfG1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGPMSnpKSzVyPUCuNFA2OThizszN NWDDOFZ1W0GQR1XS
RT-112 MnTsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYfJR|UxRTBwMEC1N|Uh|ryP MnvDV2FPT0WU
NKM-1 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXzJR|UxRTBwMEC1OFch|ryP M2P5e3NCVkeHUh?=
KYSE-180 M4TMXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUTJR|UxRTBwMEC1PFYh|ryP M1PJUHNCVkeHUh?=
SW1783 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYfJR|UxRTBwMEC1PVEh|ryP MUXTRW5ITVJ?
A431 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVSzeok3UUN3ME2wMlAxPjB5IN88US=> NYqzVIZYW0GQR1XS
SK-OV-3 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVPJR|UxRTBwMEC2N{DPxE1? NETMbZZUSU6JRWK=
RPMI-7951 NV71N5hTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3;FfmlEPTB;MD6wNFY{OSEQvF2= Ml[1V2FPT0WU
Capan-2 NIDRdFdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4jsc2lEPTB;MD6wNFY{QCEQvF2= MWDTRW5ITVJ?
HSC-3 MknjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml;4TWM2OD1yLkCwOlQyKM7:TR?= M17vSHNCVkeHUh?=
786-0 NVTyPGF6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkHFTWM2OD1yLkCwOlY{KM7:TR?= MX;TRW5ITVJ?
Daoy MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NITNO5BKSzVyPUCuNFA3QTVizszN MYjTRW5ITVJ?
KGN MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkiyTWM2OD1yLkCwO|A{KM7:TR?= NVeyNXFOW0GQR1XS
EW-16 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MU\JR|UxRTBwMEC3OFkh|ryP MnrmV2FPT0WU
EW-7 M2W4eGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFHBXWhKSzVyPUCuNFA4PTRizszN MmC5V2FPT0WU
IGROV-1 Ml\pS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnTETWM2OD1yLkCwPFE1KM7:TR?= M2LqSXNCVkeHUh?=
8505C MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFz6cohKSzVyPUCuNFA5OjFizszN M2DKNHNCVkeHUh?=
RKO MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV3WUnpGUUN3ME2wMlAxQDJ4IN88US=> NEiwNlNUSU6JRWK=
GDM-1 M4jTbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NULTfmtrUUN3ME2wMlAxQDRizszN MXvTRW5ITVJ?
IST-MEL1 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEW1XFBKSzVyPUCuNFA5PTJizszN MYHTRW5ITVJ?
RPMI-6666 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4nSXWlEPTB;MD6wNFg2OiEQvF2= MXTTRW5ITVJ?
SNG-M NWm5N4x3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF\OfIdKSzVyPUCuNFA5PTZizszN Mn;YV2FPT0WU
KS-1 M1ixc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVLJR|UxRTBwMEC4OVkh|ryP MUTTRW5ITVJ?
RXF393 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkjlTWM2OD1yLkCwPFYh|ryP MUDTRW5ITVJ?
CAL-12T MlflS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml7UTWM2OD1yLkCwPVIzKM7:TR?= MW\TRW5ITVJ?
BFTC-905 NEDvfHdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEPrSHlKSzVyPUCuNFA6OzhizszN M4jEXnNCVkeHUh?=
SK-MES-1 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXm2N29IUUN3ME2wMlAxQTR3IN88US=> M3v3UnNCVkeHUh?=
BB30-HNC MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUXKOZB6UUN3ME2wMlAxQTV{IN88US=> NGXPeHJUSU6JRWK=
AN3-CA MoPmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkPnTWM2OD1yLkCxNFE4KM7:TR?= Mm\HV2FPT0WU
EFO-27 NXfWdos2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVPJR|UxRTBwMEGwNVch|ryP MVHTRW5ITVJ?
G-401 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVvJR|UxRTBwMEGwNlUh|ryP MUfTRW5ITVJ?
BPH-1 NYXZWVB7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXLCPIhNUUN3ME2wMlAyODNizszN NGe1UGlUSU6JRWK=
NCI-H727 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHPqWXFKSzVyPUCuNFExOyEQvF2= MlrXV2FPT0WU
SNU-423 Mn3qS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2\Y[GlEPTB;MD6wNVA2OyEQvF2= MXfTRW5ITVJ?
KYSE-270 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkfTTWM2OD1yLkCxNFU6KM7:TR?= MlnGV2FPT0WU
AGS Mon2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYPrcVU3UUN3ME2wMlAyODZzIN88US=> MX7TRW5ITVJ?
NCI-H2228 NH20SZhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MluyTWM2OD1yLkCxNFY1KM7:TR?= MUjTRW5ITVJ?
SW954 NGroRmtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV;4ZoFGUUN3ME2wMlAyODdzIN88US=> NIXyR|JUSU6JRWK=
769-P M{TFT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH;EfWlKSzVyPUCuNFExPzNizszN MknWV2FPT0WU
BB49-HNC NUPmb4RET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2POVGlEPTB;MD6wNVA4PyEQvF2= NUnI[5JDW0GQR1XS
IA-LM MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIHsTFZKSzVyPUCuNFExQDZizszN MWjTRW5ITVJ?
NB69 M17tW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1vTbWlEPTB;MD6wNVExOiEQvF2= Mmj3V2FPT0WU
C8166 NWfReYw{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX3JR|UxRTBwMEGxNlkh|ryP MWHTRW5ITVJ?
NCI-H1299 NUL2em5lT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFK1TY5KSzVyPUCuNFEyPTRizszN MXzTRW5ITVJ?
YKG-1 NX;UNI5bT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH3mPHVKSzVyPUCuNFEyPiEQvF2= NVz1eFRCW0GQR1XS
PANC-03-27 M{XSV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVzJR|UxRTBwMEGxOlIh|ryP M1rtV3NCVkeHUh?=
YT NIXBSIFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEPy[oNKSzVyPUCuNFEyPzlizszN MX3TRW5ITVJ?
CAL-85-1 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkfDTWM2OD1yLkCxNVkzKM7:TR?= NYj0TFNOW0GQR1XS
GT3TKB NHnNdmtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYLJR|UxRTBwMEGyNFIh|ryP NI\xUnZUSU6JRWK=
BB65-RCC MkG5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHXBc2lKSzVyPUCuNFEzODRizszN M2HXOHNCVkeHUh?=
ES6 M{XW[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWnndIdoUUN3ME2wMlAyOjZzIN88US=> NUHNO2VzW0GQR1XS
MHH-ES-1 NYfueXA5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVWyO4djUUN3ME2wMlAyOjZ|IN88US=> NX3MTI16W0GQR1XS
QIMR-WIL MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVjqfHBCUUN3ME2wMlAyOjZ7IN88US=> NWmxW3A{W0GQR1XS
SNU-C2B MoDwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV7hUFJQUUN3ME2wMlAyOjd{IN88US=> NE\XeodUSU6JRWK=
OCI-AML2 M2HMZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFnFN3hKSzVyPUCuNFEzQDFizszN Mn3zV2FPT0WU
DU-145 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXTBdVhvUUN3ME2wMlAyOjlizszN NFm0XXpUSU6JRWK=
SW982 NUnRTo1JT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUC2cWV2UUN3ME2wMlAyOjl|IN88US=> NEDqXoxUSU6JRWK=
MFH-ino MmDhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXHoTldSUUN3ME2wMlAyOjl|IN88US=> NF7US2xUSU6JRWK=
A427 M1naTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXPlZ3Y{UUN3ME2wMlAyOjl7IN88US=> M4\2XnNCVkeHUh?=
LCLC-97TM1 NXjjOHM3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGKwZotKSzVyPUCuNFE{KM7:TR?= M3rzbHNCVkeHUh?=
AM-38 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3fWe2lEPTB;MD6wNVMxOiEQvF2= NXvYeXJNW0GQR1XS
K5 NID0UY1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{XyWGlEPTB;MD6wNVMxQCEQvF2= Ml\PV2FPT0WU
T84 MkPBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVXJR|UxRTBwMEGzN|Eh|ryP MVHTRW5ITVJ?
TE-15 NH7BWJVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVjDUGVYUUN3ME2wMlAyOzN4IN88US=> M3zRdHNCVkeHUh?=
NCI-H460 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1X5NWlEPTB;MD6wNVM{PiEQvF2= NF7J[plUSU6JRWK=
NTERA-S-cl-D1 M331[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3znUmlEPTB;MD6wNVM{QSEQvF2= NG\YTGtUSU6JRWK=
KYSE-450 NXzXR4ZtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4OzbWlEPTB;MD6wNVM1QSEQvF2= MWnTRW5ITVJ?
H4 NIfhXnVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3PjNmlEPTB;MD6wNVM3PiEQvF2= NF7WNXJUSU6JRWK=
LC-2-ad M{PZZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M331dGlEPTB;MD6wNVM4KM7:TR?= MnW1V2FPT0WU
GAMG MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2Lye2lEPTB;MD6wNVM4OSEQvF2= MXzTRW5ITVJ?
TK10 MnPvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXXJR|UxRTBwMEGzPFIh|ryP NEX4OGRUSU6JRWK=
NCI-H2122 M3fGRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Moe4TWM2OD1yLkCxN|g1KM7:TR?= M1zScHNCVkeHUh?=
KM12 M2HiTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUXJR|UxRTBwMEGzPVkh|ryP NYPtWXVRW0GQR1XS
CAL-39 NIfsNJVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mo\WTWM2OD1yLkCxOFIh|ryP MlzEV2FPT0WU
RPMI-2650 NFXYV2tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoWyTWM2OD1yLkCxOFMzKM7:TR?= NFi5OoFUSU6JRWK=
KYSE-510 MorBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYjJR|UxRTBwMEG0OFIh|ryP M4ThfHNCVkeHUh?=
KALS-1 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NITzb2pKSzVyPUCuNFE1PjZizszN NUfGPJRJW0GQR1XS
NCI-H1648 NXzEfpFLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXzJR|UxRTBwMEG0PVkh|ryP MlzrV2FPT0WU
ES4 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mmq2TWM2OD1yLkCxOVAzKM7:TR?= NGT6fWdUSU6JRWK=
C-33-A M33PNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4X5UGlEPTB;MD6wNVUxQSEQvF2= NF\jSpZUSU6JRWK=
MIA-PaCa-2 Mkj0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH3jdY1KSzVyPUCuNFE2ODlizszN MkTMV2FPT0WU
Becker MlHMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3nnVGlEPTB;MD6wNVUyPCEQvF2= MYPTRW5ITVJ?
HOP-62 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3HpNGlEPTB;MD6wNVU1OiEQvF2= MWjTRW5ITVJ?
TE-1 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHzRUVZKSzVyPUCuNFE2QDFizszN NGGwXlZUSU6JRWK=
KYSE-410 NHK1eWlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NES4VmpKSzVyPUCuNFE2QDZizszN NYjVWoNiW0GQR1XS
NOS-1 NGjKVXNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUfJR|UxRTBwMEG1PVMh|ryP NWW3W5doW0GQR1XS
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RS4-11 Mn3WS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVfJR|UxRTBwMEOzPFMh|ryP MUXTRW5ITVJ?
JiyoyeP-2003 M331Tmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFzUW|lKSzVyPUCuNFM{QDhizszN MXjTRW5ITVJ?
BL-70 NW\QdmhMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVXJR|UxRTBwMEOzPFkh|ryP NVrUOXFsW0GQR1XS
OS-RC-2 NHjtO25Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1i3RmlEPTB;MD6wN|M6PiEQvF2= NH76ZnFUSU6JRWK=
SF268 M2PpfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mor6TWM2OD1yLkCzOFAyKM7:TR?= M{\X[HNCVkeHUh?=
BV-173 MmThS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWH1bIk5UUN3ME2wMlA{PDJ4IN88US=> NUDNfG5IW0GQR1XS
DMS-273 M3jhXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUTSOJd4UUN3ME2wMlA{PDd7IN88US=> MnvPV2FPT0WU
22RV1 M3flXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVTJR|UxRTBwMEO1NFch|ryP NXHaSWFkW0GQR1XS
ES8 NHLUcZpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGqxRmFKSzVyPUCuNFM2OzhizszN MXXTRW5ITVJ?
KYSE-150 MlnaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWHJR|UxRTBwMEO2NFgh|ryP NETiNG5USU6JRWK=
HCC1569 M3fPSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVvJR|UxRTBwMEO2NFgh|ryP MUfTRW5ITVJ?
NB5 NYPSdnU2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYG4TGV1UUN3ME2wMlA{PjF|IN88US=> MnPEV2FPT0WU
G-402 NWjITnJiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVTJfHYyUUN3ME2wMlA{PjF2IN88US=> MVLTRW5ITVJ?
NCI-H1693 Mn\YS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVjJR|UxRTBwMEO2NVch|ryP M4L1UXNCVkeHUh?=
LB2241-RCC M3TVXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGe0cnNKSzVyPUCuNFM3PDJizszN M{LkfnNCVkeHUh?=
KP-4 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIPOVXdKSzVyPUCuNFM3PjNizszN MkiyV2FPT0WU
ML-2 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MofBTWM2OD1yLkCzOlcyKM7:TR?= MYLTRW5ITVJ?
KU812 NG[yOW9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVvaPXg5UUN3ME2wMlA{Pjh2IN88US=> Mo[2V2FPT0WU
LS-411N NGPyOVdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M33RbmlEPTB;MD6wN|c{OSEQvF2= M2ryW3NCVkeHUh?=
OAW-42 NFnDUJhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYTJR|UxRTBwMEO3OFch|ryP M2XKdHNCVkeHUh?=
HCC38 MkX5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3yyTGlEPTB;MD6wN|c4OSEQvF2= MnT2V2FPT0WU
Ca-Ski MnnRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{HTNmlEPTB;MD6wN|c5PCEQvF2= M2TzcnNCVkeHUh?=
Calu-3 NXfaNZhFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWfyXm1CUUN3ME2wMlA{Pzh7IN88US=> MkPqV2FPT0WU
KYSE-70 NUCzNJc{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3ftcGlEPTB;MD6wN|gyOiEQvF2= MUDTRW5ITVJ?
D-392MG NUTyUo5XT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXvJR|UxRTBwMEO4OFIh|ryP MmSzV2FPT0WU
OVCAR-4 NG\scnlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmHNTWM2OD1yLkCzPFU5KM7:TR?= NVi2b|ZWW0GQR1XS
Detroit562 M{\uNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYPJR|UxRTBwMEO4O|Ih|ryP MVnTRW5ITVJ?
HEL NFrxZ41Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NY\vVpBOUUN3ME2wMlA{QDlzIN88US=> MV3TRW5ITVJ?
MONO-MAC-6 NULudph{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWHJR|UxRTBwMEO4PVMh|ryP Mon2V2FPT0WU
LoVo NFHKVYdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGqwdppKSzVyPUCuNFM6OzNizszN NXvXVo1pW0GQR1XS
U-2-OS MonWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXH3blN1UUN3ME2wMlA{QTN3IN88US=> NIXlenFUSU6JRWK=
A172 NVvzcnBRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXzJR|UxRTBwMEO5OUDPxE1? MlTLV2FPT0WU
OCUB-M MkL5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1TZNWlEPTB;MD6wN|k3OSEQvF2= NF7IUGxUSU6JRWK=
SW48 MkXHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{nydGlEPTB;MD6wOFA{OSEQvF2= MlThV2FPT0WU
HC-1 Mk\BS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVHJR|UxRTBwMESwOlkh|ryP M{\oWnNCVkeHUh?=
KOSC-2 NIP6bJpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mki3TWM2OD1yLkC0NVEh|ryP Mny5V2FPT0WU
HDLM-2 NIf2dZBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4XIS2lEPTB;MD6wOFEyPCEQvF2= NWr1bYk6W0GQR1XS
CTV-1 NVfzd4dbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4XaXmlEPTB;MD6wOFEyPiEQvF2= NGntdJRUSU6JRWK=
SH-4 M3PPSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFTIcpFKSzVyPUCuNFQyPDFizszN M1vqUnNCVkeHUh?=
SW756 NV\2fJpoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFH6TmxKSzVyPUCuNFQyPTdizszN NI\zPWlUSU6JRWK=
GCT MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVnJR|UxRTBwMESxOlEh|ryP M1zs[HNCVkeHUh?=
CHL-1 M3j1SGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MY\JR|UxRTBwMESxOlkh|ryP MV\TRW5ITVJ?
LAMA-84 MoTDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkLWTWM2OD1yLkC0NVcyKM7:TR?= NEi1W5dUSU6JRWK=
LS-1034 MkTES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIjCU3NKSzVyPUCuNFQyQTFizszN NHvHV5ZUSU6JRWK=
NCI-H358 NFfOdW5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUHtOoJ3UUN3ME2wMlA1OjF{IN88US=> NGTLcFhUSU6JRWK=
NB13 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWTleVdNUUN3ME2wMlA1OjJ5IN88US=> NH[5OZNUSU6JRWK=
TE-9 MmHGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn3TTWM2OD1yLkC0NlM4KM7:TR?= NHG3T5NUSU6JRWK=
OE33 NHT3eppIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NE\zOWVKSzVyPUCuNFQzPDFizszN MVTTRW5ITVJ?
CAL-120 NVjBbIZFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoLETWM2OD1yLkC0NlQyKM7:TR?= NFLyc4dUSU6JRWK=
DJM-1 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NI\4W5VKSzVyPUCuNFQzPzJizszN M3vRZ3NCVkeHUh?=
SK-MEL-24 NHywTmlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlfKTWM2OD1yLkC0Nlg{KM7:TR?= NFPWTVhUSU6JRWK=
VA-ES-BJ MoTuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1rVO2lEPTB;MD6wOFI6OiEQvF2= MWrTRW5ITVJ?
MMAC-SF NH7JUZFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVPJR|UxRTBwMESyPVch|ryP MV3TRW5ITVJ?
MZ7-mel NIj4c|JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M13KWWlEPTB;MD6wOFM{KM7:TR?= NXTJVpZZW0GQR1XS
BxPC-3 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV7JR|UxRTBwMESzOFEh|ryP NHm1TmJUSU6JRWK=
HT-29 NVO3T|lRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGrKU3lKSzVyPUCuNFQ{PTdizszN NVnsTZlJW0GQR1XS
SK-MEL-30 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn\mTWM2OD1yLkC0N|YzKM7:TR?= MlfBV2FPT0WU
CAL-33 NY\OdZJvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkjNTWM2OD1yLkC0N|c2KM7:TR?= MV3TRW5ITVJ?
COLO-680N M1nqVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3\h[mlEPTB;MD6wOFQxPyEQvF2= MU\TRW5ITVJ?
NH-12 M4rQTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWn5OnplUUN3ME2wMlA1PDRizszN MVHTRW5ITVJ?
HCC1937 MlTiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX\MXmVtUUN3ME2wMlA1PDV4IN88US=> MWXTRW5ITVJ?
IMR-5 M2\aemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1rSWWlEPTB;MD6wOFQ6KM7:TR?= M3jjUXNCVkeHUh?=
MC-CAR MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnmzTWM2OD1yLkC0OVY6KM7:TR?= M33EXHNCVkeHUh?=
NCI-H747 NI[2TppIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3jlSmlEPTB;MD6wOFU4KM7:TR?= NWLlc2NVW0GQR1XS
NCI-H1792 NGXTOIdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEG4N2xKSzVyPUCuNFQ2QDFizszN NGDGcVVUSU6JRWK=
SW13 M2[1Vmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWDJR|UxRTBwMES1PUDPxE1? NXHnUo94W0GQR1XS
MLMA M2nTN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1LEZmlEPTB;MD6wOFYxQSEQvF2= MVXTRW5ITVJ?
U251 Ml71S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVvJR|UxRTBwMES3OlMh|ryP MYLTRW5ITVJ?
U031 NUftUG92T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYnJR|UxRTBwMES3O|Eh|ryP MXnTRW5ITVJ?
ME-180 NHPyO|JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmjMTWM2OD1yLkC0O|gzKM7:TR?= MWXTRW5ITVJ?
SK-MEL-3 NEDjVZVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWXJR|UxRTBwMES4NFIh|ryP NHLaeWpUSU6JRWK=
MOLT-4 M1fjNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3:yOGlEPTB;MD6wOFgxOyEQvF2= MnPlV2FPT0WU
PF-382 M{HpNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEDBXFZKSzVyPUCuNFQ5OjZizszN MlXDV2FPT0WU
NUGC-3 M3TpVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVjJR|UxRTBwMES4Nlch|ryP NYC0[nppW0GQR1XS
NCI-H1417 NF32NHhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWDJR|UxRTBwMES4PUDPxE1? NXO2b3FuW0GQR1XS
COLO-205 MkHDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1nZXGlEPTB;MD6wOFkyQSEQvF2= Mkj4V2FPT0WU
TE-441-T M1zNdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVvJR|UxRTBwMES5N{DPxE1? MlX2V2FPT0WU
MKN1 Mlz0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml:4TWM2OD1yLkC0PVMh|ryP MWjTRW5ITVJ?
UM-UC-3 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWe2PJI4UUN3ME2wMlA1QTVizszN NF3jcnpUSU6JRWK=
SF126 NULMeoZNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYDJR|UxRTBwMEWwNUDPxE1? NV3zfmFCW0GQR1XS
LB1047-RCC NVnHc2tQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NI\yXZpKSzVyPUCuNFUxOzFizszN MX7TRW5ITVJ?
A253 NWjsWYw4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2nneWlEPTB;MD6wOVA2OiEQvF2= MXPTRW5ITVJ?
NCI-H1963 M1zWSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mmf3TWM2OD1yLkC1NVc3KM7:TR?= MVTTRW5ITVJ?
VM-CUB-1 NE\QO3JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFHQdG1KSzVyPUCuNFU{OTFizszN NEfLeINUSU6JRWK=
T-24 M33uZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlPlTWM2OD1yLkC1N|g1KM7:TR?= NFLvfoRUSU6JRWK=
K-562 M3i1Wmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVrJR|UxRTBwMEWzPFch|ryP NFPZZZNUSU6JRWK=
ARH-77 NYDte4pST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEj0RohKSzVyPUCuNFU{QTVizszN MkLCV2FPT0WU
CA46 MnzCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnXxTWM2OD1yLkC1OFMh|ryP NHe5OllUSU6JRWK=
HCC70 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV7JR|UxRTBwMEW0OVIh|ryP MUDTRW5ITVJ?
ST486 NF7tRYVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1XvW2lEPTB;MD6wOVUzPSEQvF2= NYXGZXp2W0GQR1XS
COLO-741 NFK1fJBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MonyTWM2OD1yLkC1OVMyKM7:TR?= M1r5NXNCVkeHUh?=
SK-PN-DW NH7oe4tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MorUTWM2OD1yLkC1OVg5KM7:TR?= MV;TRW5ITVJ?
BL-41 MkDUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mmj3TWM2OD1yLkC1OVk3KM7:TR?= NHTFW2VUSU6JRWK=
D-263MG M{nL[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGD1XJFKSzVyPUCuNFU3QDNizszN NHWz[nFUSU6JRWK=
KE-37 NGnCNoVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnfITWM2OD1yLkC1Olg{KM7:TR?= MoPqV2FPT0WU
LU-134-A MkCyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkPYTWM2OD1yLkC1O|E2KM7:TR?= NF3lcVhUSU6JRWK=
HCC2157 NFXXUFlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnP1TWM2OD1yLkC1O|M{KM7:TR?= MVjTRW5ITVJ?
GAK NESzd5BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUnJR|UxRTBwMEW3N|Qh|ryP NYHD[|JJW0GQR1XS
IST-SL2 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWSzfXR4UUN3ME2wMlA2PzR|IN88US=> NVjhXpo2W0GQR1XS
KMOE-2 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUDYXpc1UUN3ME2wMlA2PzR7IN88US=> NXrVT4ZDW0GQR1XS
SW1573 M4PpOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX:0O5hbUUN3ME2wMlA2QDB{IN88US=> NHXNdG9USU6JRWK=
SCC-9 Mm\YS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1XuN2lEPTB;MD6wOVg4KM7:TR?= MmrXV2FPT0WU
MDA-MB-361 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHXYOWRKSzVyPUCuNFU5PzJizszN M3voSnNCVkeHUh?=
BHT-101 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnPnTWM2OD1yLkC1PFc3KM7:TR?= NVzEd5MzW0GQR1XS
NCI-H1770 NFvVdIpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4DtUmlEPTB;MD6wOVg4QSEQvF2= NFPWWVFUSU6JRWK=
UACC-893 MojRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnTxTWM2OD1yLkC1PFk3KM7:TR?= MVLTRW5ITVJ?
NCI-H226 M4jZT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4XiNWlEPTB;MD6wOVk5QCEQvF2= MVvTRW5ITVJ?
HLE M2f5OGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoDzTWM2OD1yLkC2NFgzKM7:TR?= NX[5SodrW0GQR1XS
NCI-H1703 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWPJR|UxRTBwME[xO|gh|ryP MUjTRW5ITVJ?
KURAMOCHI MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIDCdG9KSzVyPUCuNFYyQDlizszN NGG1UFlUSU6JRWK=
RH-1 NGLDbYRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1TJXGlEPTB;MD6wOlI{KM7:TR?= NFv2TmxUSU6JRWK=
DSH1 NFrHW|hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGK3WopKSzVyPUCuNFYzPyEQvF2= M{PIZnNCVkeHUh?=
CAMA-1 NHu1[IlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4PFfmlEPTB;MD6wOlMxOyEQvF2= NIjSd|JUSU6JRWK=
NCI-H1437 Ml;qS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2Lv[GlEPTB;MD6wOlMzQCEQvF2= MnHWV2FPT0WU
HuP-T4 MnfwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnzETWM2OD1yLkC2OVg3KM7:TR?= MnS0V2FPT0WU
HCT-15 M3zVTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX7JR|UxRTBwME[1PVch|ryP MWnTRW5ITVJ?
NCCIT NWfZSlBuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{j4XWlEPTB;MD6wOlYxPCEQvF2= MWrTRW5ITVJ?
BOKU NIC4XmtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXvYTHFPUUN3ME2wMlA3Pjd2IN88US=> MWLTRW5ITVJ?
FADU NITRbnFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mlr6TWM2OD1yLkC2O|Q2KM7:TR?= NF7vSlBUSU6JRWK=
SUP-T1 M4rMUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFXhSppKSzVyPUCuNFY4PiEQvF2= MYLTRW5ITVJ?
L-363 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4DIeGlEPTB;MD6wOlkxOSEQvF2= MlzQV2FPT0WU
KNS-81-FD NGq3boxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1PuemlEPTB;MD6wOlkyQCEQvF2= NHHxWXpUSU6JRWK=
SU-DHL-1 NYrpeVZQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWLJR|UxRTBwME[5NkDPxE1? NYq2fHB3W0GQR1XS
HuH-7 M1L6[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGXFeolKSzVyPUCuNFcxOzVizszN NWrYOoQ5W0GQR1XS
BT-474 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVXrRm9mUUN3ME2wMlA4ODZzIN88US=> NXLMNIoyW0GQR1XS
CAPAN-1 NWHz[oQ3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkfLTWM2OD1yLkC3NVQ{KM7:TR?= NYX6UWZ6W0GQR1XS
HEC-1 Ml[4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVnJR|UxRTBwMEexOlEh|ryP MW\TRW5ITVJ?
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HCC1187 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NULj[HptUUN3ME2xMlU2PTJ{IN88US=> MnvJV2FPT0WU
EoL-1-cell Mkm5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUHoRpQyUUN3ME2xMlU5QDh7IN88US=> M17kOXNCVkeHUh?=
HuO-3N1 M1PoS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3u2UWlEPTB;MT64N|QyOiEQvF2= MXjTRW5ITVJ?
NCI-H1793 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWPJR|UxRTFwOEe1PVMh|ryP NGjyepBUSU6JRWK=
Caov-3 MmDJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{DQPWlEPTB;Mj6wNFYzPSEQvF2= NWPU[FYzW0GQR1XS
JAR NU\QbYZLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV;JR|UxRTJwMEe5NkDPxE1? NES1[|RUSU6JRWK=
SK-MEL-28 NHTq[4ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnP5TWM2OD1{LkG4NFk5KM7:TR?= NW\uUoVNW0GQR1XS
EM-2 NIf6W2FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVLiNpZVUUN3ME2yMlIxOjl|IN88US=> M4O5[3NCVkeHUh?=
Mewo MknYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEDO[4tKSzVyPUKuNlIzPjVizszN NVXiRZRQW0GQR1XS
NCI-H720 MlfHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4XYXWlEPTB;Mj6yOlU5PSEQvF2= MXTTRW5ITVJ?
CAL-54 M2XxcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIPYfpVKSzVyPUKuNlY4QTVizszN MmHLV2FPT0WU
MC116 NXuweIxQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWHJR|UxRTJwM{[zPVch|ryP MmDZV2FPT0WU
DG-75 NWnQclZVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUnvb2xHUUN3ME2yMlQ5PTd4IN88US=> NY\FUZZvW0GQR1XS
HCC1143 NYTEVYM2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnXTTWM2OD1{LkWwOlU5KM7:TR?= MUnTRW5ITVJ?
FTC-133 NXHWeG9QT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{DDTWlEPTB;Mj61N|Y5QSEQvF2= MnTtV2FPT0WU
AsPC-1 M3fWSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXL3dmJtUUN3ME2yMlU{QTJ7IN88US=> MknZV2FPT0WU
NCI-H889 MkTQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{HLNWlEPTB;Mj61OlcxPiEQvF2= Mlr2V2FPT0WU
HT55 NYrxcVJ[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXHJR|UxRTJwNkKwNVkh|ryP NXXQRWdUW0GQR1XS
UMC-11 NWSw[2t3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1;0SGlEPTB;Mj63PFcyPSEQvF2= M4T3WHNCVkeHUh?=
P12-ICHIKAWA Mk\PS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV3XUnNjUUN3ME2yMlgzODR4IN88US=> NUn1V|dzW0GQR1XS
HCC1395 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3;GU2lEPTB;Mj65PFYxOiEQvF2= NFPYZ2JUSU6JRWK=
D-283MED NHLyXGZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3fDRWlEPTB;Mz6xPFk{PyEQvF2= NXrm[nkxW0GQR1XS
COLO-800 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX3JR|UxRTNwM{O4PVch|ryP M3fGPHNCVkeHUh?=
MFM-223 MoPJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmjLTWM2OD1|LkO2NFk4KM7:TR?= M1vGZ3NCVkeHUh?=
TE-5 MkfCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYTMTmNyUUN3ME20MlU3OTR5IN88US=> NGfqepBUSU6JRWK=
NCI-H209 M3LmS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{e5cWlEPTB;ND63PFU4OiEQvF2= NV3iWoczW0GQR1XS
SiHa M{jXdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1Hmb2lEPTB;ND65OVIxOyEQvF2= Ml\1V2FPT0WU
NCI-H1395 NFrEWlNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3jyNWlEPTB;NT6xNFY{OyEQvF2= NIfaNlhUSU6JRWK=
A498 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYfJR|UxRTVwMkGyOVEh|ryP NWHD[4gyW0GQR1XS
ES5 NEDjeoVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXqyNmJPUUN3ME21MlYyOTd6IN88US=> MoG2V2FPT0WU
MDA-MB-157 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWXHVnh4UUN3ME21MlY3PDR|IN88US=> MYLTRW5ITVJ?
NCI-H1623 M1\MbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NW\sb|l6UUN3ME21Mlg{PTV4IN88US=> M4HLfHNCVkeHUh?=
RPMI-8866 Mn63S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHriVJFKSzVyPUWuPFQ4QTJizszN NIfrOnlUSU6JRWK=
LC-1F MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4T2U2lEPTB;Nj6wPVI6OSEQvF2= Mlu0V2FPT0WU
TCCSUP MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M36wT2lEPTB;Nj62NFM1QSEQvF2= NGexbHVUSU6JRWK=
TT M4C3cmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVjJR|UxRThwM{OwNFkh|ryP M3XkeHNCVkeHUh?=
NCI-H1838 NXTv[YVkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml\QTWM2OD16LkWxO|MyKM7:TR?= NFrOT2ZUSU6JRWK=
NCI-H322M NGfSTG5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{HpXGlEPTB;OT6xOlI5OSEQvF2= M4n1PHNCVkeHUh?=
NCI-H187 M4rkTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{LLXmlEPTB;OT61NVg{PSEQvF2= NH64eGxUSU6JRWK=
SBC-1 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGDQcW5KSzVyPUmuPVM3PTZizszN NHvPRmRUSU6JRWK=
SCC-3 NVHVbnJoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MY\JR|UxRTFyLkW2O|kh|ryP NXHVfplUW0GQR1XS
SW948 NHLsbG5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn\kTWM2OD1zMD63OVEyKM7:TR?= NYLzfWlCW0GQR1XS
CPC-N NF21WGNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFr1TXFKSzVyPUGxMlAxPyEQvF2= NFPmUm5USU6JRWK=
TGBC24TKB M3PMWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{TxdGlEPTB;MUOuOVI6KM7:TR?= MnHvV2FPT0WU
NCI-H2452 MkXJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWjXWYVsUUN3ME2xOE44OyEQvF2= MmP4V2FPT0WU
Hs-578-T MnnJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWDJR|UxRTF6LkW3OVkh|ryP MYHTRW5ITVJ?
DV-90 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M331[GlEPTB;MUiuPVk1PSEQvF2= M2TkN3NCVkeHUh?=
NCI-H1563 MnfnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVK3bnR7UUN3ME2xPU44QDh6IN88US=> MYXTRW5ITVJ?
SW780 NVrRfIV4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NU[xVXJnUUN3ME2yNU4yOzF6IN88US=> NUDG[4JvW0GQR1XS
NCI-H345 MnjhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnfCTWM2OD1{MT64O|c6KM7:TR?= MlntV2FPT0WU
LB771-HNC Mn\aS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH\kTGVKSzVyPUKyMlQ5OTNizszN MUDTRW5ITVJ?
RT4 MkXOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVzJR|UxRTJ|LkOyPFIh|ryP MlfwV2FPT0WU
NCI-H82 NXz0UoVwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkP2TWM2OD1{Mz61OVI3KM7:TR?= M1vEb3NCVkeHUh?=
NCI-H524 M17x[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFXuToFKSzVyPUK0MlM5OTJizszN NH\KVXVUSU6JRWK=
SNU-C1 NUPFem46T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF;RXoRKSzVyPUK0MlkyODVizszN NHTDRWZUSU6JRWK=
NCI-SNU-16 NUO0Ro53T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnK1TWM2OD12OD6zNVQzKM7:TR?= NX7SNoN3W0GQR1XS

... Click to View More Cell Line Experimental Data

In vivo Treatment with NVP-AUY922 causes a robust antitumor response and inhibits p-Akt and VEGF expression in an HSC-2 xenograft model. [2] In BT474, NVP-AUY922 shows complete loss of ERBB2 and substantial depletion of ERα, in addition to reductions in CDK4 and phospho-ERK1/2. [3]

Protocol

Kinase Assay:[3]
+ Expand

Kinase assay:

NVP-AUY922 is dissolved in DMSO at a concentration of 10 mM. NVP-AUY922 is assessed against HSP90α, HSP90β, GRP94, TRAP-1, HSP72, and topoisomerase II. Profiling against a panel of kinases has been carried out and screening against a panel of additional enzymes and receptors is performed at Cerep.
Cell Research:[1]
+ Expand
  • Cell lines: Human gastric cancer cells NCI-N87
  • Concentrations: 1 μM
  • Incubation Time: 3 days
  • Method: Human gastric cancer cells NCI-N87 (5-7 ×103 in 50 μL/well) are seeded in 96-well plates and incubated at 37 °C for 24 hours, followed by NVP-AUY922 treatment for 1-3 days at 37 °C. After treatment, the cells are assayed by MTT method and analyzed by microplate reader.
    (Only for Reference)
Animal Research:[3]
+ Expand
  • Animal Models: Female NCr athymic mice bearing WM266.4 human melanoma xenografts
  • Formulation: In DMSO and diluted in sterile saline/Tween 20
  • Dosages: 50 mg/kg
  • Administration: Administered via i.v. or i.p.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 93 mg/mL (199.76 mM) warming
Ethanol 31 mg/mL (66.58 mM)
Water <1 mg/mL
In vivo 1% DMSO+30% polyethylene glycol+1% Tween 80 30 mg/mL

* 1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 465.54
Formula

C26H31N3O5

CAS No. 747412-49-3
Storage powder
in solvent
Synonyms VER-52296

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
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Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT01784640 Active, not recruiting Recurrent Non-small Cell Lung Cancer|Squamous Cell Lung Cancer|Stage IV Non-small Cell Lung Cancer Jonsson Comprehensive Cancer Center|National Cancer Institute (NCI) January 2014 Phase 1
NCT01922583 Active, not recruiting Non-small Cell Lung Cancer (NSCLC) National Taiwan University Hospital January 2014 Phase 2
NCT01854034 Active, not recruiting Non Small Cell Lung Cancer Massachusetts General Hospital July 2013 Phase 2
NCT01772797 Completed Anaplastic Lymphoma Kinase (ALK)|Non-small Cell Lung Cancer Novartis Pharmaceuticals|Novartis June 2013 Phase 1
NCT01752400 Active, not recruiting Non Small Cell Lung Cancer Massachusetts General Hospital January 2013 Phase 2
NCT01613950 Completed Stomach Neoplasms Esophageal Neoplasms Metastatic Gastric Cancer Mutated PI3KCA Protein Overexpressed HER2 Protein Novartis Pharmaceuticals|Novartis December 2012 Phase 1

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID