Luminespib (AUY-922, NVP-AUY922)

Catalog No.S1069 Synonyms: VER-52296

Luminespib (AUY-922, NVP-AUY922) Chemical Structure

Molecular Weight(MW): 465.54

Luminespib (AUY-922, NVP-AUY922) is a highly potent HSP90 inhibitor for HSP90α/β with IC50 of 13 nM /21 nM in cell-free assays, weaker potency against the HSP90 family members GRP94 and TRAP-1, exhibits the tightest binding of any small-molecule HSP90 ligand. Phase 2.

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In DMSO USD 320 In stock
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3 Customer Reviews

  • U2OS_exo cells were incubated with AUY922 for 20 h at the indicated concentrations before stimulation with TNFα (30 ng/mL) for 30 min and immunostaining to detect NF-κB (p65). DMSO 1%, cells stimulated by TNFα in the absence of AUY922. Representative pictures used to quantify nuclear and cytoplasmic localization of NF-κB.

    Proc Natl Acad Sci USA, 2014, 111(15): E1528–37 . Luminespib (AUY-922, NVP-AUY922) purchased from Selleck.

    J Biol Chem 2013 288(23), 16308-20. Luminespib (AUY-922, NVP-AUY922) purchased from Selleck.

  • Western blots show the molecular signature of HSP90 inhibition by NVP-AUY922  (ie, induction of HSP72 and depletion of client proteins such as ERBB2, CRAF and CDK4) in BT474 breast cancer cell line. GAPDH was used as loading control.

     

     

    2011 Dr. Swee Sharp and Professor Paul Workman from Cancer Research UK. Luminespib (AUY-922, NVP-AUY922) purchased from Selleck.

Purity & Quality Control

Choose Selective HSP (e.g. HSP90) Inhibitors

Biological Activity

Description Luminespib (AUY-922, NVP-AUY922) is a highly potent HSP90 inhibitor for HSP90α/β with IC50 of 13 nM /21 nM in cell-free assays, weaker potency against the HSP90 family members GRP94 and TRAP-1, exhibits the tightest binding of any small-molecule HSP90 ligand. Phase 2.
Targets
HSP90α [1]
(Cell-free assay)
HSP90β [1]
(Cell-free assay)
13 nM 21 nM
In vitro

NVP-AUY922 inhibits proliferation of various human cancer cell lines in vitro, with an average GI50 of 9 nM. [1] The IC50 values of NVP-AUY922 fall in the range of 2 to 40 nM in these gastric cancer cell lines. IC50 value for the BEAS-2B cells is 28.49 nM. Treatment with NVP-AUY922 does not influence the expression of HSP90, but expression of HSP70 gets elevated by NVP-AUY922 treatment. NVP-AUY922 increases the binding of HSP70 to HSP90. NVP-AUY922 causes p23 dissociation from the HSP90 complex and can then recruit HSP70 to the HSP90 complex. [1] After the treatment with NVP-AUY922, expression of receptor tyrosine kinases including VEGFR1, 2, 3 and PDGFRɑ is decreased. A decrease is also noticed in the expression of Akt and phospho-Akt. Meanwhile, treatment with NVP-AUY922 causes decreased expression of HER-2 in NCI-N87 cells. NVP-AUY922 treatment results in binding of HSP90 to client proteins and setting them up as targets for degradation by the proteasome. NVP-AUY922 can influence cell growth by affecting multiple signaling pathways. In addition, treatment with the proteasome inhibitor, MG132, restores expression of thymidylate synthase, which is decreased by NVP-AUY922. NVP-AUY922 increases the expression of cleaved caspase-3 leading to apoptosis in HSC-2 cells.[1]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
CMK MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2HQWGlEPTB;MD6wNFAyOjVizszN MYPTRW5ITVJ?
MV-4-11 M{nHeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGrLOFZKSzVyPUCuNFAxPTV6IN88US=> NWmyW4RIW0GQR1XS
NALM-6 NWXLNIQ5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoHoTWM2OD1yLkCwNFg1OiEQvF2= M{SzNHNCVkeHUh?=
HOS NXTn[FdUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGHSOYlKSzVyPUCuNFAyOzhizszN MnXEV2FPT0WU
HT-144 NFvIbmZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGjzS2pKSzVyPUCuNFAyPTVizszN NFu1UHZUSU6JRWK=
SW1710 NXjTdHg2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnPRTWM2OD1yLkCwNVg3KM7:TR?= NHva[XRUSU6JRWK=
TE-8 MlGzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlfnTWM2OD1yLkCwNlM4KM7:TR?= MYDTRW5ITVJ?
ES1 Mn7FS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mm[zTWM2OD1yLkCwNlY3KM7:TR?= NYXpdZN4W0GQR1XS
CCF-STTG1 NUHUPI9wT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmP5TWM2OD1yLkCwNlk4KM7:TR?= MWDTRW5ITVJ?
PSN1 NYrZboxxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlnmTWM2OD1yLkCwN|E5KM7:TR?= M4HKV3NCVkeHUh?=
CAL-51 NFHmO4RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWnJR|UxRTBwMECzNlUh|ryP NXfZVHVvW0GQR1XS
MCF7 NVHQNYN2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV;kWpN[UUN3ME2wMlAxOzN3IN88US=> NUn5NIpuW0GQR1XS
SK-HEP-1 NI\ScoVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{DMRmlEPTB;MD6wNFM{PiEQvF2= NVXleYM1W0GQR1XS
LCLC-103H NVv0T|FRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4TSNGlEPTB;MD6wNFQ{KM7:TR?= M4nYSXNCVkeHUh?=
HMV-II Mkj0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV36V5I4UUN3ME2wMlAxPDR7IN88US=> NVe1S5RmW0GQR1XS
MES-SA M2nXcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYHJR|UxRTBwMEC0OVIh|ryP M3qyR3NCVkeHUh?=
SK-LMS-1 MnLUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVnmWmpEUUN3ME2wMlAxPDV6IN88US=> MofPV2FPT0WU
639-V NUnYeIpET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXPJOnF1UUN3ME2wMlAxPDh3IN88US=> NXj0NnFOW0GQR1XS
SIG-M5 M3XJdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWK4e3B4UUN3ME2wMlAxPDh7IN88US=> MmLLV2FPT0WU
LOUCY MkDOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWnidY1GUUN3ME2wMlAxPTB3IN88US=> NHrJUGZUSU6JRWK=
HSC-2 MoTZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVnJR|UxRTBwMEC1NVgh|ryP NELpe4RUSU6JRWK=
EW-13 NFP5PFZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1z6dWlEPTB;MD6wNFUyQCEQvF2= NHzFTnpUSU6JRWK=
RT-112 M1nOSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHrQVWtKSzVyPUCuNFA2OzVizszN MW\TRW5ITVJ?
NKM-1 NF\HbZNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUTkZ25FUUN3ME2wMlAxPTR5IN88US=> MmnSV2FPT0WU
KYSE-180 MlrGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF\kZYRKSzVyPUCuNFA2QDZizszN MnzqV2FPT0WU
SW1783 NFnzO3pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUDIdplKUUN3ME2wMlAxPTlzIN88US=> M1vvPXNCVkeHUh?=
A431 NU[4b2gyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4ru[mlEPTB;MD6wNFYxPyEQvF2= NFzZTJBUSU6JRWK=
SK-OV-3 NYDLPIxkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M33tcWlEPTB;MD6wNFY{KM7:TR?= Ml3JV2FPT0WU
RPMI-7951 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF\De5FKSzVyPUCuNFA3OzFizszN M2r3bXNCVkeHUh?=
Capan-2 NHfsW2NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHm0PZFKSzVyPUCuNFA3OzhizszN NIfEfIhUSU6JRWK=
HSC-3 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{jXVWlEPTB;MD6wNFY1OSEQvF2= MUXTRW5ITVJ?
786-0 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUT0TlV3UUN3ME2wMlAxPjZ|IN88US=> NYHmTW5OW0GQR1XS
Daoy M{XpUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M13CcmlEPTB;MD6wNFY6PSEQvF2= M1vMRnNCVkeHUh?=
KGN NHLKVHdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M36xR2lEPTB;MD6wNFcxOyEQvF2= NELB[plUSU6JRWK=
EW-16 NF7hO|dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NY\IZpNPUUN3ME2wMlAxPzR7IN88US=> Mk\QV2FPT0WU
EW-7 NVrBSo9rT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoK2TWM2OD1yLkCwO|U1KM7:TR?= MUDTRW5ITVJ?
IGROV-1 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFfJT5VKSzVyPUCuNFA5OTRizszN NV30fY04W0GQR1XS
8505C NVG2RVZoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVrJR|UxRTBwMEC4NlEh|ryP M1G5NXNCVkeHUh?=
RKO Mk\vS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUHwSWN{UUN3ME2wMlAxQDJ4IN88US=> M3z3fnNCVkeHUh?=
GDM-1 M{\ne2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1jNfGlEPTB;MD6wNFg1KM7:TR?= MVrTRW5ITVJ?
IST-MEL1 MnHKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEjZc4hKSzVyPUCuNFA5PTJizszN NVTINYZoW0GQR1XS
RPMI-6666 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1nvVGlEPTB;MD6wNFg2OiEQvF2= MYfTRW5ITVJ?
SNG-M M4PmUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mo[zTWM2OD1yLkCwPFU3KM7:TR?= NW\mTFdzW0GQR1XS
KS-1 NHrrVlZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1LTN2lEPTB;MD6wNFg2QSEQvF2= NFvmSoNUSU6JRWK=
RXF393 NFO0VZpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV;uPHZyUUN3ME2wMlAxQDZizszN NIrsVGhUSU6JRWK=
CAL-12T MoPhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NULHSFR3UUN3ME2wMlAxQTJ{IN88US=> MnzKV2FPT0WU
BFTC-905 M3XlbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2XZN2lEPTB;MD6wNFk{QCEQvF2= M13OOXNCVkeHUh?=
SK-MES-1 NW\4PVF{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkjRTWM2OD1yLkCwPVQ2KM7:TR?= M3vKT3NCVkeHUh?=
BB30-HNC M{\0OGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUDJR|UxRTBwMEC5OVIh|ryP M4DKN3NCVkeHUh?=
AN3-CA MnnOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYPJR|UxRTBwMEGwNVch|ryP M4DPPHNCVkeHUh?=
EFO-27 MmLDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYnjdYRbUUN3ME2wMlAyODF5IN88US=> NEjVc4RUSU6JRWK=
G-401 MkezS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M373XGlEPTB;MD6wNVAzPSEQvF2= NVP6XIE1W0GQR1XS
BPH-1 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1rRWmlEPTB;MD6wNVA{KM7:TR?= M{\CZnNCVkeHUh?=
NCI-H727 M1nORWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWjOcnJxUUN3ME2wMlAyODNizszN Moj4V2FPT0WU
SNU-423 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFna[pVKSzVyPUCuNFExPTNizszN MYLTRW5ITVJ?
KYSE-270 MnHTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3vrNGlEPTB;MD6wNVA2QSEQvF2= MWnTRW5ITVJ?
AGS NEHtU5dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFLaWmlKSzVyPUCuNFExPjFizszN M3XSOXNCVkeHUh?=
NCI-H2228 M{\4NWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIK1TJVKSzVyPUCuNFExPjRizszN NWX0VY04W0GQR1XS
SW954 MmCwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml\jTWM2OD1yLkCxNFcyKM7:TR?= MWrTRW5ITVJ?
769-P M1\GUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEThdndKSzVyPUCuNFExPzNizszN NETLcGRUSU6JRWK=
BB49-HNC NFjtN3RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{PEcWlEPTB;MD6wNVA4PyEQvF2= M{LsOXNCVkeHUh?=
IA-LM MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUe1[ohsUUN3ME2wMlAyODh4IN88US=> NX33bFRLW0GQR1XS
NB69 NFXxTmNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{K3bGlEPTB;MD6wNVExOiEQvF2= NGnCUWdUSU6JRWK=
C8166 M1S3Tmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MW\JR|UxRTBwMEGxNlkh|ryP MnrvV2FPT0WU
NCI-H1299 NX2wcolpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWfUS5NsUUN3ME2wMlAyOTV2IN88US=> MWLTRW5ITVJ?
YKG-1 M1[1eGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1\0d2lEPTB;MD6wNVE3KM7:TR?= MUTTRW5ITVJ?
PANC-03-27 M3j1Zmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVvv[YpJUUN3ME2wMlAyOTZ{IN88US=> M{nPXXNCVkeHUh?=
YT NFzH[GxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV7JR|UxRTBwMEGxO|kh|ryP NX72bnVSW0GQR1XS
CAL-85-1 NX63cpdmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnPETWM2OD1yLkCxNVkzKM7:TR?= MoDwV2FPT0WU
GT3TKB MlHhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWTp[plIUUN3ME2wMlAyOjB{IN88US=> MonVV2FPT0WU
BB65-RCC M1THU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHvCWZRKSzVyPUCuNFEzODRizszN MUDTRW5ITVJ?
ES6 MlPRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXXJR|UxRTBwMEGyOlEh|ryP Mlv4V2FPT0WU
MHH-ES-1 NWLsSXI3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NW\1eld1UUN3ME2wMlAyOjZ|IN88US=> MofvV2FPT0WU
QIMR-WIL MorIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVTJR|UxRTBwMEGyOlkh|ryP M3fqZnNCVkeHUh?=
SNU-C2B MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEnlSJVKSzVyPUCuNFEzPzJizszN MV3TRW5ITVJ?
OCI-AML2 MoTSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFLUZ3ZKSzVyPUCuNFEzQDFizszN NHOyWJhUSU6JRWK=
DU-145 MnrIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGrkeGFKSzVyPUCuNFEzQSEQvF2= NF\wR4RUSU6JRWK=
SW982 M3HHXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIr1ZoRKSzVyPUCuNFEzQTNizszN NIXLTGtUSU6JRWK=
MFH-ino NFzRWIlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXztTJZOUUN3ME2wMlAyOjl|IN88US=> NGO4THFUSU6JRWK=
A427 NIDVcpFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUTJR|UxRTBwMEGyPVkh|ryP NFfjb4FUSU6JRWK=
LCLC-97TM1 MmjvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUjJR|UxRTBwMEGzJO69VQ>? M{LjR3NCVkeHUh?=
AM-38 NEnteGxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MonwTWM2OD1yLkCxN|AzKM7:TR?= MWfTRW5ITVJ?
K5 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MULJR|UxRTBwMEGzNFgh|ryP M3TINnNCVkeHUh?=
T84 NX\zb3FGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1vYNmlEPTB;MD6wNVM{OSEQvF2= NHXpemFUSU6JRWK=
TE-15 Ml\1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIfVZ49KSzVyPUCuNFE{OzZizszN MomwV2FPT0WU
NCI-H460 NVz5bIVVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1fVbGlEPTB;MD6wNVM{PiEQvF2= MVLTRW5ITVJ?
NTERA-S-cl-D1 NFG4U|lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoTsTWM2OD1yLkCxN|M6KM7:TR?= M2nLcHNCVkeHUh?=
KYSE-450 NW\xeJp4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX\JR|UxRTBwMEGzOFkh|ryP M3\2bHNCVkeHUh?=
H4 MmHzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1\jZWlEPTB;MD6wNVM3PiEQvF2= NEHlZ4xUSU6JRWK=
LC-2-ad NH32SZNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXLJR|UxRTBwMEGzO{DPxE1? MX;TRW5ITVJ?
GAMG M1z5TGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWroXGVmUUN3ME2wMlAyOzdzIN88US=> NEG0N|ZUSU6JRWK=
TK10 MnH6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkPCTWM2OD1yLkCxN|gzKM7:TR?= NGPmZlBUSU6JRWK=
NCI-H2122 NVXFXlluT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVe1S4lbUUN3ME2wMlAyOzh2IN88US=> Mon1V2FPT0WU
KM12 NVjYd3NQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYXx[5ZOUUN3ME2wMlAyOzl7IN88US=> M{DtOXNCVkeHUh?=
CAL-39 NEjOO5BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1LJU2lEPTB;MD6wNVQzKM7:TR?= MoLIV2FPT0WU
RPMI-2650 NUDLWXpUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIrGdZpKSzVyPUCuNFE1OzJizszN MVzTRW5ITVJ?
KYSE-510 NInvU2pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUTYVmhSUUN3ME2wMlAyPDR{IN88US=> NYj0Xmh4W0GQR1XS
KALS-1 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2HQWWlEPTB;MD6wNVQ3PiEQvF2= MmPSV2FPT0WU
NCI-H1648 NYHIRXN6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFexPYFKSzVyPUCuNFE1QTlizszN Mmr3V2FPT0WU
ES4 NHnMPFFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoLlTWM2OD1yLkCxOVAzKM7:TR?= MlGyV2FPT0WU
C-33-A MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHewNoVKSzVyPUCuNFE2ODlizszN MnTXV2FPT0WU
MIA-PaCa-2 NX[5cmVJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWPlXmVsUUN3ME2wMlAyPTB7IN88US=> MX7TRW5ITVJ?
Becker NYi2UllFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVnJR|UxRTBwMEG1NVQh|ryP M1nmeHNCVkeHUh?=
HOP-62 NEjnboRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUfJR|UxRTBwMEG1OFIh|ryP MYLTRW5ITVJ?
TE-1 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXfJR|UxRTBwMEG1PFEh|ryP M4rZVHNCVkeHUh?=
KYSE-410 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoDHTWM2OD1yLkCxOVg3KM7:TR?= NVLydJNbW0GQR1XS
NOS-1 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEDaeppKSzVyPUCuNFE2QTNizszN MoPMV2FPT0WU
MEL-HO MoLiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUfCd2pLUUN3ME2wMlAyPjR|IN88US=> MVHTRW5ITVJ?
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JiyoyeP-2003 NYPMblJwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkTGTWM2OD1yLkCzN|g5KM7:TR?= NWTZNnY4W0GQR1XS
BL-70 MkLxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV;qZW9bUUN3ME2wMlA{Ozh7IN88US=> MVjTRW5ITVJ?
OS-RC-2 M{\6Rmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYDJR|UxRTBwMEOzPVYh|ryP MlOxV2FPT0WU
SF268 NHrxc3lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnHSTWM2OD1yLkCzOFAyKM7:TR?= M1TyWnNCVkeHUh?=
BV-173 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXnnV5ExUUN3ME2wMlA{PDJ4IN88US=> NVLqVpF1W0GQR1XS
DMS-273 M2fQemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGSwN5VKSzVyPUCuNFM1PzlizszN NWDSXmxXW0GQR1XS
22RV1 MlvVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXXMeIttUUN3ME2wMlA{PTB5IN88US=> NEjmWXNUSU6JRWK=
ES8 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVPJR|UxRTBwMEO1N|gh|ryP MUfTRW5ITVJ?
KYSE-150 MkPtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmfxTWM2OD1yLkCzOlA5KM7:TR?= MY\TRW5ITVJ?
HCC1569 NXq3PJEyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2\zeGlEPTB;MD6wN|YxQCEQvF2= MlLXV2FPT0WU
NB5 NXzNbIVDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVHqcWVSUUN3ME2wMlA{PjF|IN88US=> NVLN[|FmW0GQR1XS
G-402 NFO3bpJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXnJR|UxRTBwMEO2NVQh|ryP M3HzO3NCVkeHUh?=
NCI-H1693 NHTEZXpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmXDTWM2OD1yLkCzOlE4KM7:TR?= NULGcHBPW0GQR1XS
LB2241-RCC NXiyWYtNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXfEWnJpUUN3ME2wMlA{PjR{IN88US=> NWjCSZhYW0GQR1XS
KP-4 MmC3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYCwW4w6UUN3ME2wMlA{PjZ|IN88US=> NGfWOHJUSU6JRWK=
ML-2 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWrJR|UxRTBwMEO2O|Eh|ryP Mmi3V2FPT0WU
KU812 MoDvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGjCbodKSzVyPUCuNFM3QDRizszN NEXUUmtUSU6JRWK=
LS-411N MoDIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWnjVYUyUUN3ME2wMlA{PzNzIN88US=> MkDYV2FPT0WU
OAW-42 M3vs[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXrBcIxbUUN3ME2wMlA{PzR5IN88US=> Mlz0V2FPT0WU
HCC38 NHe5OphIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{nqbWlEPTB;MD6wN|c4OSEQvF2= NEHBOYRUSU6JRWK=
Ca-Ski NEHTUZJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEfRS45KSzVyPUCuNFM4QDRizszN NEHCd49USU6JRWK=
Calu-3 NWHUUZFIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV75dFhEUUN3ME2wMlA{Pzh7IN88US=> Mm[zV2FPT0WU
KYSE-70 MlvIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUTJR|UxRTBwMEO4NVIh|ryP Mn63V2FPT0WU
D-392MG M4DyeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MonoTWM2OD1yLkCzPFQzKM7:TR?= NVPtTIs{W0GQR1XS
OVCAR-4 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIrN[m5KSzVyPUCuNFM5PThizszN NIXHNpNUSU6JRWK=
Detroit562 M4rDZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mm[xTWM2OD1yLkCzPFczKM7:TR?= NXK3NmM5W0GQR1XS
HEL MnfoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWHQcnF3UUN3ME2wMlA{QDlzIN88US=> MWjTRW5ITVJ?
MONO-MAC-6 NFntdJRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEPQc3hKSzVyPUCuNFM5QTNizszN MV7TRW5ITVJ?
LoVo NXrvS|huT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M37NVGlEPTB;MD6wN|k{OyEQvF2= Mlz5V2FPT0WU
U-2-OS MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFLHfVJKSzVyPUCuNFM6OzVizszN M1TaTXNCVkeHUh?=
A172 NV7M[pIxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGrsSIZKSzVyPUCuNFM6PSEQvF2= MYXTRW5ITVJ?
OCUB-M NVjqZm9UT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUPPXIpzUUN3ME2wMlA{QTZzIN88US=> NFTxN5dUSU6JRWK=
SW48 MoLwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFmzToJKSzVyPUCuNFQxOzFizszN MXnTRW5ITVJ?
HC-1 NV3ENG1rT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmLkTWM2OD1yLkC0NFY6KM7:TR?= Mn:yV2FPT0WU
KOSC-2 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnjPTWM2OD1yLkC0NVEh|ryP Ml23V2FPT0WU
HDLM-2 M1PaPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHfCS|RKSzVyPUCuNFQyOTRizszN NVnVU|dtW0GQR1XS
CTV-1 NVXQcXNGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWS4cpl6UUN3ME2wMlA1OTF4IN88US=> NXr2UngzW0GQR1XS
SH-4 Mn\SS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXfmWVk4UUN3ME2wMlA1OTRzIN88US=> NV2xeGJwW0GQR1XS
SW756 NYT0fFFtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXHJR|UxRTBwMESxOVch|ryP M2Xwe3NCVkeHUh?=
GCT MlTGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoPzTWM2OD1yLkC0NVYyKM7:TR?= MXjTRW5ITVJ?
CHL-1 NYPrdnlQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUHuXGdwUUN3ME2wMlA1OTZ7IN88US=> M134XXNCVkeHUh?=
LAMA-84 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{ntPGlEPTB;MD6wOFE4OSEQvF2= MWDTRW5ITVJ?
LS-1034 NWPXNW5xT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn33TWM2OD1yLkC0NVkyKM7:TR?= NHixfZBUSU6JRWK=
NCI-H358 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEfmNFlKSzVyPUCuNFQzOTJizszN NWCxbpMyW0GQR1XS
NB13 NH64N2JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUnwVm4xUUN3ME2wMlA1OjJ5IN88US=> NV3DS2RxW0GQR1XS
TE-9 NF3DN5VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIXtTo1KSzVyPUCuNFQzOzdizszN NHfWRpRUSU6JRWK=
OE33 NGWycG1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFjwVppKSzVyPUCuNFQzPDFizszN M1;renNCVkeHUh?=
CAL-120 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml\pTWM2OD1yLkC0NlQyKM7:TR?= NVHERWl3W0GQR1XS
DJM-1 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUnJR|UxRTBwMESyO|Ih|ryP NV\qNYJuW0GQR1XS
SK-MEL-24 NXfiToVWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWjSVI5{UUN3ME2wMlA1Ojh|IN88US=> NFS1c4RUSU6JRWK=
VA-ES-BJ M4\6R2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGrQSlRKSzVyPUCuNFQzQTJizszN NHHWT2xUSU6JRWK=
MMAC-SF NYPyXFlVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3zRcWlEPTB;MD6wOFI6PyEQvF2= Mnm1V2FPT0WU
MZ7-mel NUXE[WN{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEDqOW9KSzVyPUCuNFQ{OyEQvF2= MXzTRW5ITVJ?
BxPC-3 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVrJR|UxRTBwMESzOFEh|ryP MkWxV2FPT0WU
HT-29 M13iSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1XxTGlEPTB;MD6wOFM2PyEQvF2= NF7sZmhUSU6JRWK=
SK-MEL-30 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4Lq[WlEPTB;MD6wOFM3OiEQvF2= NWmzbmFSW0GQR1XS
CAL-33 NX3FSmVyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoCzTWM2OD1yLkC0N|c2KM7:TR?= M1LUbnNCVkeHUh?=
COLO-680N MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVTJR|UxRTBwMES0NFch|ryP MlnVV2FPT0WU
NH-12 NGrDR4RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHXTN3JKSzVyPUCuNFQ1PCEQvF2= MmftV2FPT0WU
HCC1937 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX\JR|UxRTBwMES0OVYh|ryP NGW4fGRUSU6JRWK=
IMR-5 NH[0SmRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGLteYdKSzVyPUCuNFQ1QSEQvF2= M4e0N3NCVkeHUh?=
MC-CAR MnfvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFjkSY9KSzVyPUCuNFQ2PjlizszN NH:z[JRUSU6JRWK=
NCI-H747 MlWxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVvJR|UxRTBwMES1O{DPxE1? M1\hUXNCVkeHUh?=
NCI-H1792 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWHxPY56UUN3ME2wMlA1PThzIN88US=> NVPPWItqW0GQR1XS
SW13 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{nXc2lEPTB;MD6wOFU6KM7:TR?= NVj0SY5IW0GQR1XS
MLMA MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3qxR2lEPTB;MD6wOFYxQSEQvF2= NEXTNnhUSU6JRWK=
U251 M3;w[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYDJR|UxRTBwMES3OlMh|ryP Ml7xV2FPT0WU
U031 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUPJR|UxRTBwMES3O|Eh|ryP MXXTRW5ITVJ?
ME-180 M1TVPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4nVVWlEPTB;MD6wOFc5OiEQvF2= NG[wbldUSU6JRWK=
SK-MEL-3 M4Hrb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXf4W4JCUUN3ME2wMlA1QDB{IN88US=> NE\KNFJUSU6JRWK=
MOLT-4 MoPyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn3BTWM2OD1yLkC0PFA{KM7:TR?= M2rKSXNCVkeHUh?=
PF-382 NU\xV21zT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGrFW4FKSzVyPUCuNFQ5OjZizszN NWHh[3pkW0GQR1XS
NUGC-3 MlLSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NI\CT|ZKSzVyPUCuNFQ5OjdizszN M3fHe3NCVkeHUh?=
NCI-H1417 M3zncWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml;sTWM2OD1yLkC0PFkh|ryP MYDTRW5ITVJ?
COLO-205 MmnaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUnJR|UxRTBwMES5NVkh|ryP MXTTRW5ITVJ?
TE-441-T MoL3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXK5bYxFUUN3ME2wMlA1QTNizszN NYrPSZdPW0GQR1XS
MKN1 NVLjVJNuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUHJR|UxRTBwMES5N{DPxE1? M13XVnNCVkeHUh?=
UM-UC-3 NXTFOIo1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2fSPGlEPTB;MD6wOFk2KM7:TR?= NFnZZ3JUSU6JRWK=
SF126 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIXXN4dKSzVyPUCuNFUxOSEQvF2= NHHpOZVUSU6JRWK=
LB1047-RCC NIXuOINIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MW\JR|UxRTBwMEWwN|Eh|ryP MX\TRW5ITVJ?
A253 MmOwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml76TWM2OD1yLkC1NFUzKM7:TR?= NUf6[nlnW0GQR1XS
NCI-H1963 NEPQSYtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIDiZYNKSzVyPUCuNFUyPzZizszN M2fMdXNCVkeHUh?=
VM-CUB-1 NX[xTIwxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3rJfGlEPTB;MD6wOVMyOSEQvF2= M3:zcXNCVkeHUh?=
T-24 M{DMOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV\uVFRCUUN3ME2wMlA2Ozh2IN88US=> M1zodXNCVkeHUh?=
K-562 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2rCc2lEPTB;MD6wOVM5PyEQvF2= MoLrV2FPT0WU
ARH-77 M{Cyemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYLqSotZUUN3ME2wMlA2Ozl3IN88US=> M3TnfXNCVkeHUh?=
CA46 M{LHTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYrJR|UxRTBwMEW0N{DPxE1? MVPTRW5ITVJ?
HCC70 NEnwRlJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWPNeI9RUUN3ME2wMlA2PDV{IN88US=> MWTTRW5ITVJ?
ST486 NVjzfoVqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYPJR|UxRTBwMEW1NlUh|ryP NXHsW2M4W0GQR1XS
COLO-741 NUnBUnlHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn2xTWM2OD1yLkC1OVMyKM7:TR?= NHrhSZJUSU6JRWK=
SK-PN-DW M{\OT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{fSeGlEPTB;MD6wOVU5QCEQvF2= NFzHSVhUSU6JRWK=
BL-41 MkXhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF[y[pZKSzVyPUCuNFU2QTZizszN MX7TRW5ITVJ?
D-263MG M4Dzd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGXmZ3lKSzVyPUCuNFU3QDNizszN MmDtV2FPT0WU
KE-37 M2fTZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3G4fGlEPTB;MD6wOVY5OyEQvF2= MnH3V2FPT0WU
LU-134-A NEHm[XFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{DzTWlEPTB;MD6wOVcyPSEQvF2= NIHTeGZUSU6JRWK=
HCC2157 MmKzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVvJR|UxRTBwMEW3N|Mh|ryP NX\m[nc{W0GQR1XS
GAK NFfFRndIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NULVWHlnUUN3ME2wMlA2PzN2IN88US=> M4jIXnNCVkeHUh?=
IST-SL2 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVjyU2Y4UUN3ME2wMlA2PzR|IN88US=> MVHTRW5ITVJ?
KMOE-2 M1zEPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1\Lb2lEPTB;MD6wOVc1QSEQvF2= MnXpV2FPT0WU
SW1573 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXnJR|UxRTBwMEW4NFIh|ryP M2jsU3NCVkeHUh?=
SCC-9 M3jVcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnyxTWM2OD1yLkC1PFch|ryP NGHsV2tUSU6JRWK=
MDA-MB-361 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX7MTm1[UUN3ME2wMlA2QDd{IN88US=> NHL5XmtUSU6JRWK=
BHT-101 NX3zb3NPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWjv[oRrUUN3ME2wMlA2QDd4IN88US=> MnHIV2FPT0WU
NCI-H1770 NILDXFdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4DNOmlEPTB;MD6wOVg4QSEQvF2= NHr2[IpUSU6JRWK=
UACC-893 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUWzboczUUN3ME2wMlA2QDl4IN88US=> MY\TRW5ITVJ?
NCI-H226 M2\ufGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoraTWM2OD1yLkC1PVg5KM7:TR?= MYDTRW5ITVJ?
HLE M1LNOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUjrXZh4UUN3ME2wMlA3ODh{IN88US=> MYXTRW5ITVJ?
NCI-H1703 NXHzW5BST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXTJR|UxRTBwME[xO|gh|ryP NFLRXHRUSU6JRWK=
KURAMOCHI MonLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWnJR|UxRTBwME[xPFkh|ryP NYnLV|hjW0GQR1XS
RH-1 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUD1cYZ6UUN3ME2wMlA3OjNizszN MlyyV2FPT0WU
DSH1 Mo\mS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{PhVmlEPTB;MD6wOlI4KM7:TR?= M{f5[HNCVkeHUh?=
CAMA-1 NUG4Z|NuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWK1NFRZUUN3ME2wMlA3OzB|IN88US=> MmjHV2FPT0WU
NCI-H1437 NEDKT4ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmmzTWM2OD1yLkC2N|I5KM7:TR?= M2TQV3NCVkeHUh?=
HuP-T4 NHn4R|ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHiyO5BKSzVyPUCuNFY2QDZizszN NVy0TmRsW0GQR1XS
HCT-15 Mo\jS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnywTWM2OD1yLkC2OVk4KM7:TR?= MmPEV2FPT0WU
NCCIT NH35Vm5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnLQTWM2OD1yLkC2OlA1KM7:TR?= M4LEWHNCVkeHUh?=
BOKU M1naZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH;NToJKSzVyPUCuNFY3PzRizszN NES4SXNUSU6JRWK=
FADU NEL0[XpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2\rdmlEPTB;MD6wOlc1PSEQvF2= M2nDfHNCVkeHUh?=
SUP-T1 NYf5U5JRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF;ueJhKSzVyPUCuNFY4PiEQvF2= MX;TRW5ITVJ?
L-363 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1XhWmlEPTB;MD6wOlkxOSEQvF2= NVTEWYd[W0GQR1XS
KNS-81-FD MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2jLZWlEPTB;MD6wOlkyQCEQvF2= M3rD[nNCVkeHUh?=
SU-DHL-1 M4TyPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVi4W2k5UUN3ME2wMlA3QTJizszN MoTiV2FPT0WU
HuH-7 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVjJR|UxRTBwMEewN|Uh|ryP Mn;xV2FPT0WU
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CAPAN-1 NF3KfXZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYnJR|UxRTBwMEexOFMh|ryP MVTTRW5ITVJ?
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NCI-H748 Mlr1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3jvRmlEPTB;MT6zOVc{QCEQvF2= NIr6[nBUSU6JRWK=
HCC1187 NGTPZW5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn;oTWM2OD1zLkW1OVIzKM7:TR?= M4f5V3NCVkeHUh?=
EoL-1-cell MlzzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYfJR|UxRTFwNUi4PFkh|ryP NGjKTZlUSU6JRWK=
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Caov-3 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3yxNWlEPTB;Mj6wNFYzPSEQvF2= MUTTRW5ITVJ?
JAR MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVHJR|UxRTJwMEe5NkDPxE1? M3vLTXNCVkeHUh?=
SK-MEL-28 NIrD[oFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4\veWlEPTB;Mj6xPFA6QCEQvF2= M{HoVHNCVkeHUh?=
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NCI-H720 NV;PdVRkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWXJR|UxRTJwMk[1PFUh|ryP MX7TRW5ITVJ?
CAL-54 M3\GWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MljaTWM2OD1{LkK2O|k2KM7:TR?= NXrSbYQ5W0GQR1XS
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DG-75 NHLHfXBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnrrTWM2OD1{LkS4OVc3KM7:TR?= MXvTRW5ITVJ?
HCC1143 NYC0T|RoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnPGTWM2OD1{LkWwOlU5KM7:TR?= MU\TRW5ITVJ?
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NCI-H889 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2izXmlEPTB;Mj61OlcxPiEQvF2= M1vxeXNCVkeHUh?=
HT55 NVjJdXFIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH7NVXlKSzVyPUKuOlIxOTlizszN MnrhV2FPT0WU
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D-283MED MlH4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4rkW2lEPTB;Mz6xPFk{PyEQvF2= MUXTRW5ITVJ?
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MFM-223 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoPaTWM2OD1|LkO2NFk4KM7:TR?= MlrZV2FPT0WU
TE-5 NGrGUZVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVPPWVE4UUN3ME20MlU3OTR5IN88US=> MkPIV2FPT0WU
NCI-H209 MmDMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoXITWM2OD12Lke4OVczKM7:TR?= NEfKUlNUSU6JRWK=
SiHa M4LrXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUTDfGlyUUN3ME20Mlk2OjB|IN88US=> MYfTRW5ITVJ?
NCI-H1395 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MULJR|UxRTVwMUC2N|Mh|ryP NW\pRoN6W0GQR1XS
A498 NWXVR21[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWLJR|UxRTVwMkGyOVEh|ryP NH;HNoxUSU6JRWK=
ES5 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH;NSWdKSzVyPUWuOlEyPzhizszN M1fGdHNCVkeHUh?=
MDA-MB-157 Ml30S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIrRUWZKSzVyPUWuOlY1PDNizszN M1ew[3NCVkeHUh?=
NCI-H1623 M{P1emdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{jCVmlEPTB;NT64N|U2PiEQvF2= M3LGSHNCVkeHUh?=
RPMI-8866 M1XSe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3fTOGlEPTB;NT64OFc6OiEQvF2= NUXhe5lwW0GQR1XS
LC-1F NY\G[3VTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3rFPWlEPTB;Nj6wPVI6OSEQvF2= M3vHdnNCVkeHUh?=
TCCSUP M1TsdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHLqe|ZKSzVyPU[uOlA{PDlizszN M3\RZ3NCVkeHUh?=
TT MnzqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYDJR|UxRThwM{OwNFkh|ryP NETvTFdUSU6JRWK=
NCI-H1838 M17wUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{DIbWlEPTB;OD61NVc{OSEQvF2= MUHTRW5ITVJ?
NCI-H322M M1fucGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1rHNmlEPTB;OT6xOlI5OSEQvF2= MYLTRW5ITVJ?
NCI-H187 M4TnNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWjJR|UxRTlwNUG4N|Uh|ryP M3XPfHNCVkeHUh?=
SBC-1 NVTRNI81T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1ftXmlEPTB;OT65N|Y2PiEQvF2= MUfTRW5ITVJ?
SCC-3 NHXNbphIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYfJR|UxRTFyLkW2O|kh|ryP M{LUXXNCVkeHUh?=
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TGBC24TKB MmTDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUi3WIlwUUN3ME2xN{42OjlizszN MUTTRW5ITVJ?
NCI-H2452 MnvjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV:0Z5VGUUN3ME2xOE44OyEQvF2= NGjQdWxUSU6JRWK=
Hs-578-T NVzySGpuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3XTU2lEPTB;MUiuOVc2QSEQvF2= MWHTRW5ITVJ?
DV-90 MojYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWC0SVN[UUN3ME2xPE46QTR3IN88US=> NH3WVI5USU6JRWK=
NCI-H1563 M1XObGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYnJR|UxRTF7Lke4PFgh|ryP NGL4dWhUSU6JRWK=
SW780 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIPUWmZKSzVyPUKxMlE{OThizszN NHXVeWlUSU6JRWK=
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LB771-HNC MnTYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoX4TWM2OD1{Mj60PFE{KM7:TR?= MkmxV2FPT0WU
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NCI-H82 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml3RTWM2OD1{Mz61OVI3KM7:TR?= MVzTRW5ITVJ?
NCI-H524 NVLvTVlKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX;JR|UxRTJ2LkO4NVIh|ryP MlO5V2FPT0WU
SNU-C1 NXvqcFZYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUXXPWZrUUN3ME2yOE46OTB3IN88US=> Mn7xV2FPT0WU
NCI-SNU-16 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1XO[mlEPTB;NEiuN|E1OiEQvF2= NF;obYRUSU6JRWK=

... Click to View More Cell Line Experimental Data

In vivo Treatment with NVP-AUY922 causes a robust antitumor response and inhibits p-Akt and VEGF expression in an HSC-2 xenograft model. [2] In BT474, NVP-AUY922 shows complete loss of ERBB2 and substantial depletion of ERα, in addition to reductions in CDK4 and phospho-ERK1/2. [3]

Protocol

Kinase Assay:[3]
+ Expand

Kinase assay:

NVP-AUY922 is dissolved in DMSO at a concentration of 10 mM. NVP-AUY922 is assessed against HSP90α, HSP90β, GRP94, TRAP-1, HSP72, and topoisomerase II. Profiling against a panel of kinases has been carried out and screening against a panel of additional enzymes and receptors is performed at Cerep.
Cell Research:[1]
+ Expand
  • Cell lines: Human gastric cancer cells NCI-N87
  • Concentrations: 1 μM
  • Incubation Time: 3 days
  • Method: Human gastric cancer cells NCI-N87 (5-7 ×103 in 50 μL/well) are seeded in 96-well plates and incubated at 37 °C for 24 hours, followed by NVP-AUY922 treatment for 1-3 days at 37 °C. After treatment, the cells are assayed by MTT method and analyzed by microplate reader.
    (Only for Reference)
Animal Research:[3]
+ Expand
  • Animal Models: Female NCr athymic mice bearing WM266.4 human melanoma xenografts
  • Formulation: In DMSO and diluted in sterile saline/Tween 20
  • Dosages: 50 mg/kg
  • Administration: Administered via i.v. or i.p.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 93 mg/mL warmed (199.76 mM)
Ethanol 31 mg/mL (66.58 mM)
Water Insoluble
In vivo Add solvents to the product individually and in order:
1% DMSO+30% polyethylene glycol+1% Tween 80
For best results, use promptly after mixing.
30 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 465.54
Formula

C26H31N3O5

CAS No. 747412-49-3
Storage powder
Synonyms VER-52296

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

  • Mass
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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
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    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
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    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT01784640 Active, not recruiting Recurrent Non-small Cell Lung Cancer|Squamous Cell Lung Cancer|Stage IV Non-small Cell Lung Cancer Jonsson Comprehensive Cancer Center|National Cancer Institute (NCI) January 2014 Phase 1
NCT01922583 Active, not recruiting Non-small Cell Lung Cancer (NSCLC) National Taiwan University Hospital January 2014 Phase 2
NCT01854034 Active, not recruiting Non Small Cell Lung Cancer Massachusetts General Hospital July 2013 Phase 2
NCT01772797 Completed Anaplastic Lymphoma Kinase (ALK)|Non-small Cell Lung Cancer Novartis Pharmaceuticals|Novartis June 2013 Phase 1
NCT01752400 Active, not recruiting Non Small Cell Lung Cancer Massachusetts General Hospital January 2013 Phase 2
NCT01613950 Completed Stomach Neoplasms Esophageal Neoplasms Metastatic Gastric Cancer Mutated PI3KCA Protein Overexpressed HER2 Protein Novartis Pharmaceuticals|Novartis December 2012 Phase 1

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

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HSP (e.g. HSP90) Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID