Luminespib (AUY-922, NVP-AUY922)

Catalog No.S1069 Synonyms: VER-52296

Luminespib (AUY-922, NVP-AUY922) Chemical Structure

Molecular Weight(MW): 465.54

Luminespib (AUY-922, NVP-AUY922) is a highly potent HSP90 inhibitor for HSP90α/β with IC50 of 13 nM /21 nM in cell-free assays, weaker potency against the HSP90 family members GRP94 and TRAP-1, exhibits the tightest binding of any small-molecule HSP90 ligand. Phase 2.

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In DMSO USD 320 In stock
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3 Customer Reviews

  • U2OS_exo cells were incubated with AUY922 for 20 h at the indicated concentrations before stimulation with TNFα (30 ng/mL) for 30 min and immunostaining to detect NF-κB (p65). DMSO 1%, cells stimulated by TNFα in the absence of AUY922. Representative pictures used to quantify nuclear and cytoplasmic localization of NF-κB.

    Proc Natl Acad Sci USA, 2014, 111(15): E1528–37 . Luminespib (AUY-922, NVP-AUY922) purchased from Selleck.

    J Biol Chem 2013 288(23), 16308-20. Luminespib (AUY-922, NVP-AUY922) purchased from Selleck.

  • Western blots show the molecular signature of HSP90 inhibition by NVP-AUY922  (ie, induction of HSP72 and depletion of client proteins such as ERBB2, CRAF and CDK4) in BT474 breast cancer cell line. GAPDH was used as loading control.

     

     

    2011 Dr. Swee Sharp and Professor Paul Workman from Cancer Research UK. Luminespib (AUY-922, NVP-AUY922) purchased from Selleck.

Purity & Quality Control

Choose Selective HSP (e.g. HSP90) Inhibitors

Biological Activity

Description Luminespib (AUY-922, NVP-AUY922) is a highly potent HSP90 inhibitor for HSP90α/β with IC50 of 13 nM /21 nM in cell-free assays, weaker potency against the HSP90 family members GRP94 and TRAP-1, exhibits the tightest binding of any small-molecule HSP90 ligand. Phase 2.
Targets
HSP90α [1]
(Cell-free assay)
HSP90β [1]
(Cell-free assay)
13 nM 21 nM
In vitro

NVP-AUY922 inhibits proliferation of various human cancer cell lines in vitro, with an average GI50 of 9 nM. [1] The IC50 values of NVP-AUY922 fall in the range of 2 to 40 nM in these gastric cancer cell lines. IC50 value for the BEAS-2B cells is 28.49 nM. Treatment with NVP-AUY922 does not influence the expression of HSP90, but expression of HSP70 gets elevated by NVP-AUY922 treatment. NVP-AUY922 increases the binding of HSP70 to HSP90. NVP-AUY922 causes p23 dissociation from the HSP90 complex and can then recruit HSP70 to the HSP90 complex. [1] After the treatment with NVP-AUY922, expression of receptor tyrosine kinases including VEGFR1, 2, 3 and PDGFRɑ is decreased. A decrease is also noticed in the expression of Akt and phospho-Akt. Meanwhile, treatment with NVP-AUY922 causes decreased expression of HER-2 in NCI-N87 cells. NVP-AUY922 treatment results in binding of HSP90 to client proteins and setting them up as targets for degradation by the proteasome. NVP-AUY922 can influence cell growth by affecting multiple signaling pathways. In addition, treatment with the proteasome inhibitor, MG132, restores expression of thymidylate synthase, which is decreased by NVP-AUY922. NVP-AUY922 increases the expression of cleaved caspase-3 leading to apoptosis in HSC-2 cells.[1]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
CMK NEi0d4ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnjOTWM2OD1yLkCwNFEzPSEQvF2= NWTGTY1MW0GQR1XS
MV-4-11 MmjCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYPJR|UxRTBwMECwOVU5KM7:TR?= NGH2WXRUSU6JRWK=
NALM-6 NXzYe4dbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4TwTmlEPTB;MD6wNFA5PDJizszN NIr2WoFUSU6JRWK=
HOS NXzO[lltT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWXJR|UxRTBwMECxN|gh|ryP MVXTRW5ITVJ?
HT-144 M3nIOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MknuTWM2OD1yLkCwNVU2KM7:TR?= Mn60V2FPT0WU
SW1710 NGLHTZNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVPJR|UxRTBwMECxPFYh|ryP NIm4OpBUSU6JRWK=
TE-8 Moe3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml\CTWM2OD1yLkCwNlM4KM7:TR?= NXewZ4Y5W0GQR1XS
ES1 NVTGbWpPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYPJR|UxRTBwMECyOlYh|ryP NUfEXY9mW0GQR1XS
CCF-STTG1 NVTLO2FpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIGzeJpKSzVyPUCuNFAzQTdizszN NWHnV3BoW0GQR1XS
PSN1 NWjPWJNYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3;FWGlEPTB;MD6wNFMyQCEQvF2= MX;TRW5ITVJ?
CAL-51 NHSxZmlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MW\JR|UxRTBwMECzNlUh|ryP M{LO[HNCVkeHUh?=
MCF7 M{L6VWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXzvdYZxUUN3ME2wMlAxOzN3IN88US=> NFjDPXJUSU6JRWK=
SK-HEP-1 NYqxcGxjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3PNV2lEPTB;MD6wNFM{PiEQvF2= NYDFfYxQW0GQR1XS
LCLC-103H M1PuOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGHVdG5KSzVyPUCuNFA1OyEQvF2= NHSwbHdUSU6JRWK=
HMV-II NFnRc5lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3SxW2lEPTB;MD6wNFQ1QSEQvF2= M2DXUXNCVkeHUh?=
MES-SA NVPZXFR1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Moe3TWM2OD1yLkCwOFUzKM7:TR?= NIjOZmRUSU6JRWK=
SK-LMS-1 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWKwWGhNUUN3ME2wMlAxPDV6IN88US=> NWWyOpJXW0GQR1XS
639-V NIDqdZBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUHobFd{UUN3ME2wMlAxPDh3IN88US=> NWLpfmplW0GQR1XS
SIG-M5 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWfJR|UxRTBwMEC0PFkh|ryP M1jFU3NCVkeHUh?=
LOUCY MnX2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlLXTWM2OD1yLkCwOVA2KM7:TR?= NGTSS|dUSU6JRWK=
HSC-2 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYe0UZRjUUN3ME2wMlAxPTF6IN88US=> NHLpeYFUSU6JRWK=
EW-13 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVP2fmFEUUN3ME2wMlAxPTF6IN88US=> NHTDdnRUSU6JRWK=
RT-112 MkHyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2H0[WlEPTB;MD6wNFU{PSEQvF2= M4njUXNCVkeHUh?=
NKM-1 MnvjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXTUdFhXUUN3ME2wMlAxPTR5IN88US=> MUDTRW5ITVJ?
KYSE-180 M13PT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXzJR|UxRTBwMEC1PFYh|ryP NIjDW25USU6JRWK=
SW1783 Mn;ZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUDkTpRCUUN3ME2wMlAxPTlzIN88US=> NV3tW5B{W0GQR1XS
A431 MlPvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoH4TWM2OD1yLkCwOlA4KM7:TR?= M1LPPXNCVkeHUh?=
SK-OV-3 NWi5coV6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mk[zTWM2OD1yLkCwOlMh|ryP Mn3vV2FPT0WU
RPMI-7951 NVHTN4NqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2DrVmlEPTB;MD6wNFY{OSEQvF2= MkfCV2FPT0WU
Capan-2 NXnrR|lwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlH6TWM2OD1yLkCwOlM5KM7:TR?= M1XIZ3NCVkeHUh?=
HSC-3 M1zJOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmLGTWM2OD1yLkCwOlQyKM7:TR?= MkXDV2FPT0WU
786-0 Mn7RS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHvkcZBKSzVyPUCuNFA3PjNizszN M4roSXNCVkeHUh?=
Daoy NYDXfJl6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4fuXWlEPTB;MD6wNFY6PSEQvF2= NYTqe|FVW0GQR1XS
KGN M2X0WGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoTkTWM2OD1yLkCwO|A{KM7:TR?= MYfTRW5ITVJ?
EW-16 MnvxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2H2T2lEPTB;MD6wNFc1QSEQvF2= MlnkV2FPT0WU
EW-7 M{fMdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MY\JR|UxRTBwMEC3OVQh|ryP MnTHV2FPT0WU
IGROV-1 Mn7uS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFW0SHpKSzVyPUCuNFA5OTRizszN NWO0XGJHW0GQR1XS
8505C NUHrd5dDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3LQc2lEPTB;MD6wNFgzOSEQvF2= MkLaV2FPT0WU
RKO MlLJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIPET4tKSzVyPUCuNFA5OjZizszN M4DIOHNCVkeHUh?=
GDM-1 Mm\PS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHTaenlKSzVyPUCuNFA5PCEQvF2= MXTTRW5ITVJ?
IST-MEL1 MoDWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWrvcHlvUUN3ME2wMlAxQDV{IN88US=> M3r4R3NCVkeHUh?=
RPMI-6666 NVjpV3hYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYDJR|UxRTBwMEC4OVIh|ryP MoTNV2FPT0WU
SNG-M NITUcZVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUPPUYduUUN3ME2wMlAxQDV4IN88US=> NFXaUIlUSU6JRWK=
KS-1 M2PWNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXrL[olCUUN3ME2wMlAxQDV7IN88US=> MlzhV2FPT0WU
RXF393 NICxW|RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEjY[odKSzVyPUCuNFA5PiEQvF2= NEXNWY5USU6JRWK=
CAL-12T NYHhcFJOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYTabm85UUN3ME2wMlAxQTJ{IN88US=> MlLoV2FPT0WU
BFTC-905 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGHJRXZKSzVyPUCuNFA6OzhizszN MmjIV2FPT0WU
SK-MES-1 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYTJR|UxRTBwMEC5OFUh|ryP M2TsbnNCVkeHUh?=
BB30-HNC MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{i2W2lEPTB;MD6wNFk2OiEQvF2= NELYZWhUSU6JRWK=
AN3-CA M2m2eGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYrJR|UxRTBwMEGwNVch|ryP MVPTRW5ITVJ?
EFO-27 NEPyTHhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1P6NWlEPTB;MD6wNVAyPyEQvF2= MX7TRW5ITVJ?
G-401 NIXWcVNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3LWZmlEPTB;MD6wNVAzPSEQvF2= NX\ZTmF1W0GQR1XS
BPH-1 M3e5XGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWjteGdoUUN3ME2wMlAyODNizszN M1zNSXNCVkeHUh?=
NCI-H727 MkW3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{e1OWlEPTB;MD6wNVA{KM7:TR?= NXnBSFltW0GQR1XS
SNU-423 NGPlbJhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIiyU4RKSzVyPUCuNFExPTNizszN NUi5[4xzW0GQR1XS
KYSE-270 MmTIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2H3WmlEPTB;MD6wNVA2QSEQvF2= MWTTRW5ITVJ?
AGS MnrSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXrJR|UxRTBwMEGwOlEh|ryP MmW1V2FPT0WU
NCI-H2228 M{P4N2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUHOV4pKUUN3ME2wMlAyODZ2IN88US=> NXLQ[WJ6W0GQR1XS
SW954 NIXseJBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVfJR|UxRTBwMEGwO|Eh|ryP M1nZS3NCVkeHUh?=
769-P NVfPdow6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnvJTWM2OD1yLkCxNFc{KM7:TR?= NEToSmtUSU6JRWK=
BB49-HNC MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV3JR|UxRTBwMEGwO|ch|ryP M4DH[HNCVkeHUh?=
IA-LM MnroS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWfJR|UxRTBwMEGwPFYh|ryP M1vyPHNCVkeHUh?=
NB69 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX\oR2t[UUN3ME2wMlAyOTB{IN88US=> M2TKNnNCVkeHUh?=
C8166 NH3VTlZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH;sPVBKSzVyPUCuNFEyOjlizszN M{XXTXNCVkeHUh?=
NCI-H1299 NFX5ZodIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWTJR|UxRTBwMEGxOVQh|ryP M1nDNXNCVkeHUh?=
YKG-1 NWnSTnQ3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVHJR|UxRTBwMEGxOkDPxE1? NY\F[nZSW0GQR1XS
PANC-03-27 M2nCO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoPkTWM2OD1yLkCxNVYzKM7:TR?= Mke0V2FPT0WU
YT Ml;CS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXjJR|UxRTBwMEGxO|kh|ryP MnK0V2FPT0WU
CAL-85-1 Mk\MS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkHuTWM2OD1yLkCxNVkzKM7:TR?= M1;YdXNCVkeHUh?=
GT3TKB MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVPJR|UxRTBwMEGyNFIh|ryP NXPtXItOW0GQR1XS
BB65-RCC MkXtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnHYTWM2OD1yLkCxNlA1KM7:TR?= MXTTRW5ITVJ?
ES6 NHP1O5hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2PqOmlEPTB;MD6wNVI3OSEQvF2= MUTTRW5ITVJ?
MHH-ES-1 M3\yRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHn5[2hKSzVyPUCuNFEzPjNizszN NFj3WHdUSU6JRWK=
QIMR-WIL M{Lafmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWfJR|UxRTBwMEGyOlkh|ryP M1;rTHNCVkeHUh?=
SNU-C2B MnL0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlrpTWM2OD1yLkCxNlczKM7:TR?= Mo[1V2FPT0WU
OCI-AML2 NHzsdIpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWfYdm9CUUN3ME2wMlAyOjhzIN88US=> NWLHZo5kW0GQR1XS
DU-145 NHG2cJFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXi4eXFLUUN3ME2wMlAyOjlizszN MUHTRW5ITVJ?
SW982 NVWxdXlOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkX3TWM2OD1yLkCxNlk{KM7:TR?= MVPTRW5ITVJ?
MFH-ino NH\hS2tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHy2d2xKSzVyPUCuNFEzQTNizszN MVPTRW5ITVJ?
A427 MlzhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXPXdZFkUUN3ME2wMlAyOjl7IN88US=> M3\oUnNCVkeHUh?=
LCLC-97TM1 M{f1PWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUDJR|UxRTBwMEGzJO69VQ>? MUfTRW5ITVJ?
AM-38 NF[1TZBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2DLVWlEPTB;MD6wNVMxOiEQvF2= MXfTRW5ITVJ?
K5 M4TEU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1nLZ2lEPTB;MD6wNVMxQCEQvF2= NIfUcndUSU6JRWK=
T84 MkHzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlntTWM2OD1yLkCxN|MyKM7:TR?= MWDTRW5ITVJ?
TE-15 NGrpRWNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEPYPZFKSzVyPUCuNFE{OzZizszN MlTzV2FPT0WU
NCI-H460 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1nCS2lEPTB;MD6wNVM{PiEQvF2= MVrTRW5ITVJ?
NTERA-S-cl-D1 M1jjOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIThToxKSzVyPUCuNFE{OzlizszN MnXzV2FPT0WU
KYSE-450 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1PuZ2lEPTB;MD6wNVM1QSEQvF2= NXO5SHlRW0GQR1XS
H4 NFrzTWlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3TjcGlEPTB;MD6wNVM3PiEQvF2= MnmwV2FPT0WU
LC-2-ad MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmrPTWM2OD1yLkCxN|ch|ryP MkHCV2FPT0WU
GAMG NXr4ZXpIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlG1TWM2OD1yLkCxN|cyKM7:TR?= MnHLV2FPT0WU
TK10 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHLYPHVKSzVyPUCuNFE{QDJizszN M2nONHNCVkeHUh?=
NCI-H2122 NXjrVnJ4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MontTWM2OD1yLkCxN|g1KM7:TR?= MlzmV2FPT0WU
KM12 MnjxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M33wU2lEPTB;MD6wNVM6QSEQvF2= NX;qeItxW0GQR1XS
CAL-39 M{HCcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M12zcWlEPTB;MD6wNVQzKM7:TR?= MXXTRW5ITVJ?
RPMI-2650 NHXUW5JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NInUPIxKSzVyPUCuNFE1OzJizszN M1;2d3NCVkeHUh?=
KYSE-510 M{PXdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHvOe5JKSzVyPUCuNFE1PDJizszN MlHHV2FPT0WU
KALS-1 NHL3fmtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MorqTWM2OD1yLkCxOFY3KM7:TR?= M2fHfnNCVkeHUh?=
NCI-H1648 NXW1Z41IT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWjVb|BKUUN3ME2wMlAyPDl7IN88US=> MYfTRW5ITVJ?
ES4 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmTqTWM2OD1yLkCxOVAzKM7:TR?= M2foN3NCVkeHUh?=
C-33-A M{jxSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEPQU4JKSzVyPUCuNFE2ODlizszN MWHTRW5ITVJ?
MIA-PaCa-2 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH;6[W5KSzVyPUCuNFE2ODlizszN NGfYbG9USU6JRWK=
Becker NGnFfGpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkH1TWM2OD1yLkCxOVE1KM7:TR?= MlzXV2FPT0WU
HOP-62 M3HJWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEfTZphKSzVyPUCuNFE2PDJizszN M13J[XNCVkeHUh?=
TE-1 M2PMZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVjJR|UxRTBwMEG1PFEh|ryP M1rwSnNCVkeHUh?=
KYSE-410 NIjDeZlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmDnTWM2OD1yLkCxOVg3KM7:TR?= NVn0T5RLW0GQR1XS
NOS-1 MojlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkHJTWM2OD1yLkCxOVk{KM7:TR?= M4rqSnNCVkeHUh?=
MEL-HO MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2rjb2lEPTB;MD6wNVY1OyEQvF2= MUDTRW5ITVJ?
NCI-H1650 NHjZcYNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkfmTWM2OD1yLkCxOlQ3KM7:TR?= MV;TRW5ITVJ?
VMRC-RCZ Ml7hS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MofaTWM2OD1yLkCxOlUyKM7:TR?= MoLJV2FPT0WU
HuP-T3 NHXVdlRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHPjO|FKSzVyPUCuNFE3PTNizszN M2XZUXNCVkeHUh?=
ACN MorhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGXhS2pKSzVyPUCuNFE3PTdizszN MWTTRW5ITVJ?
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HT-1197 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX\sXmJbUUN3ME2wMlAyPjh3IN88US=> NEDEOXJUSU6JRWK=
NCI-H2030 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlTRTWM2OD1yLkCxOlk4KM7:TR?= NIDsNYhUSU6JRWK=
A4-Fuk MlXES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXnJR|UxRTBwMEG3NFIh|ryP MljwV2FPT0WU
NCI-H292 MnTHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVnJR|UxRTBwMEG3NFkh|ryP MoGxV2FPT0WU
A2780 NXu1cGJGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYPJR|UxRTBwMEG3NVUh|ryP M3jQdHNCVkeHUh?=
SF295 MmTuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVewXnFFUUN3ME2wMlAyPzJzIN88US=> NXXURnpFW0GQR1XS
NCI-H810 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4fmNGlEPTB;MD6wNVczPCEQvF2= MlmxV2FPT0WU
ALL-PO NGDGcIpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkTLTWM2OD1yLkCxO|M2KM7:TR?= M2XJPHNCVkeHUh?=
MC-IXC MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmnSTWM2OD1yLkCxO|M3KM7:TR?= MXnTRW5ITVJ?
NY MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1O5fmlEPTB;MD6wNVc1KM7:TR?= MYjTRW5ITVJ?
OMC-1 NGTTW2FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmrwTWM2OD1yLkCxO|UyKM7:TR?= MUTTRW5ITVJ?
PANC-10-05 NXfrelBVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MknTTWM2OD1yLkCxO|U2KM7:TR?= M17DPXNCVkeHUh?=
NCI-H2342 M3yzXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFPFRmZKSzVyPUCuNFE4PThizszN NV;sSG42W0GQR1XS
HGC-27 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{PUTGlEPTB;MD6wNVc2QCEQvF2= Ml;KV2FPT0WU
TE-12 NHr6dVZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF3hOVRKSzVyPUCuNFE4PzVizszN MXzTRW5ITVJ?
MOLT-16 M2fNcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlnqTWM2OD1yLkCxO|g5KM7:TR?= Ml7HV2FPT0WU
HL-60 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mo\5TWM2OD1yLkCxPFA4KM7:TR?= NYLofGlbW0GQR1XS
OVCAR-5 M3;Db2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUXjNVR3UUN3ME2wMlAyQDF{IN88US=> MWHTRW5ITVJ?
SK-LU-1 NVPFWI9FT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGfpenlKSzVyPUCuNFE5PDZizszN MV\TRW5ITVJ?
MG-63 MnjnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mo\ETWM2OD1yLkCxPFc1KM7:TR?= NIG5PXRUSU6JRWK=
8-MG-BA NYTVN5E1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NELONFNKSzVyPUCuNFE5QDRizszN MoL2V2FPT0WU
COR-L105 NXraPG9HT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGrReYtKSzVyPUCuNFE6OTFizszN MlHvV2FPT0WU
BHY MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnKzTWM2OD1yLkCxPVEzKM7:TR?= M4L4TXNCVkeHUh?=
SW620 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2H4fGlEPTB;MD6wNVkyPSEQvF2= Mmm5V2FPT0WU
PC-14 NV\SOYZbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NULaXZJ4UUN3ME2wMlAyQTN2IN88US=> NGX2[FZUSU6JRWK=
NCI-H522 NI\vbJVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIK5V3lKSzVyPUCuNFE6OzlizszN M2r0d3NCVkeHUh?=
OE19 NV\zR|I6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWH1NXdxUUN3ME2wMlAyQTVizszN NXPwdIZVW0GQR1XS
RVH-421 NESwbIZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MU\JR|UxRTBwMEG5OVch|ryP NXvYT|JPW0GQR1XS
TE-10 NIH6e5FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVXJR|UxRTBwMEG5O|ch|ryP NGnseVhUSU6JRWK=
A101D MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2D5fGlEPTB;MD6wNVk5PyEQvF2= MXLTRW5ITVJ?
HUTU-80 NU\HT4FbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3LLbGlEPTB;MD6wNlAxPCEQvF2= MXfTRW5ITVJ?
KYSE-140 M4D6Tmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkPITWM2OD1yLkCyNFI1KM7:TR?= NHTC[ZVUSU6JRWK=
SNU-449 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkHpTWM2OD1yLkCyNFI3KM7:TR?= MmrWV2FPT0WU
697 Mni4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVXJR|UxRTBwMEKwN|Eh|ryP NVnwblV[W0GQR1XS
SJSA-1 M33kN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX3JR|UxRTBwMEKwN|ch|ryP NYrBe3Z3W0GQR1XS
IGR-1 NFrafpNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUPJR|UxRTBwMEKwOUDPxE1? NEXSZpdUSU6JRWK=
GCIY MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHnvbmhKSzVyPUCuNFIxPTVizszN NYjzNm5MW0GQR1XS
REH NELOdpZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXrJR|UxRTBwMEKwOVkh|ryP M{DqT3NCVkeHUh?=
A204 NHHOTI1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXLjfGpGUUN3ME2wMlAzOTF3IN88US=> NWr0ZVFZW0GQR1XS
A388 NELQPWFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{S3WGlEPTB;MD6wNlEyPSEQvF2= NVrJ[m5ZW0GQR1XS
NCI-H650 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MknsTWM2OD1yLkCyNVE4KM7:TR?= MkDOV2FPT0WU
SW626 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4nt[2lEPTB;MD6wNlEzKM7:TR?= NGrWVXpUSU6JRWK=
DoTc2-4510 M2faVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkXwTWM2OD1yLkCyNVIzKM7:TR?= NIjsbGtUSU6JRWK=
HCE-4 NXuxOohjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX:wcZJtUUN3ME2wMlAzOTR3IN88US=> MUPTRW5ITVJ?
DU-4475 NGHBTnNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFzMWHdKSzVyPUCuNFIyPSEQvF2= M{KwWXNCVkeHUh?=
A375 NXLGSIhrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml7zTWM2OD1yLkCyNVcyKM7:TR?= NV6zN2M3W0GQR1XS
GB-1 NUKyNmo{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWPJR|UxRTBwMEKxPFgh|ryP NGPSbmJUSU6JRWK=
CHP-212 M3\1UWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWjJR|UxRTBwMEKyNVIh|ryP M2f6UHNCVkeHUh?=
HT-1080 NVrGU|RbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXHBR4Q5UUN3ME2wMlAzOjF2IN88US=> NEX4SY9USU6JRWK=
M059J NHnKdmdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoDkTWM2OD1yLkCyNlQyKM7:TR?= MYjTRW5ITVJ?
NMC-G1 NFvNfFVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{LKSGlEPTB;MD6wNlI5KM7:TR?= M1n3cHNCVkeHUh?=
MRK-nu-1 M4HXc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3\VOGlEPTB;MD6wNlMh|ryP NELFVllUSU6JRWK=
MFE-296 M3fXOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHLSN2lKSzVyPUCuNFI{OjJizszN Mom0V2FPT0WU
LOXIMVI M{nOPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkPHTWM2OD1yLkCyN|I{KM7:TR?= M2DQPHNCVkeHUh?=
CGTH-W-1 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2TQTmlEPTB;MD6wNlMzQCEQvF2= NY\XN4tXW0GQR1XS
CCRF-CEM MlG2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV25cVVGUUN3ME2wMlAzOzJ7IN88US=> NY\zVWg{W0GQR1XS
ACHN MmPMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYTJR|UxRTBwMEKzOFUh|ryP M1PsOnNCVkeHUh?=
NCI-H1355 M4P6PWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXrJR|UxRTBwMEK0NFEh|ryP Mn7iV2FPT0WU
NCI-H1651 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mmf3TWM2OD1yLkCyOFMyKM7:TR?= MVnTRW5ITVJ?
KINGS-1 MnX3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3fhcWlEPTB;MD6wNlQ{OyEQvF2= NYK4NpRsW0GQR1XS
LS-123 NV\ae2xET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkHKTWM2OD1yLkCyOFM2KM7:TR?= MkTHV2FPT0WU
SNB75 NHvRSXFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUDJR|UxRTBwMEK0OlYh|ryP NH:wS2FUSU6JRWK=
C3A MnfSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1HFT2lEPTB;MD6wNlQ4PSEQvF2= NGL3fXVUSU6JRWK=
HO-1-N-1 M2q5[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXTpWnVuUUN3ME2wMlAzPTR7IN88US=> M{LQSHNCVkeHUh?=
EHEB MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV\sZ2ZzUUN3ME2wMlAzPTV3IN88US=> NIXJT4dUSU6JRWK=
CAL-62 NXu4VZpxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{\3XWlEPTB;MD6wNlU4KM7:TR?= NGDJZlVUSU6JRWK=
U-118-MG M1jweGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHPSdZZKSzVyPUCuNFI2PzZizszN MUTTRW5ITVJ?
HN NXrkRnl6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3LFNGlEPTB;MD6wNlU6OyEQvF2= MWnTRW5ITVJ?
HTC-C3 NEKybG9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV\JR|UxRTBwMEK2NFch|ryP M2TiXnNCVkeHUh?=
KYSE-520 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4LId2lEPTB;MD6wNlYyOyEQvF2= NHzsS|BUSU6JRWK=
MZ1-PC NIr3bYRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX\QNpNuUUN3ME2wMlAzPjN7IN88US=> MUTTRW5ITVJ?
BCPAP MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYfZcHBUUUN3ME2wMlAzPjR4IN88US=> NI[0WXZUSU6JRWK=
RD NVTFdFkyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnS1TWM2OD1yLkCyOlU5KM7:TR?= MVTTRW5ITVJ?
NCI-H520 NHfS[VRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mnu5TWM2OD1yLkCyOlY1KM7:TR?= NGPGdJNUSU6JRWK=
LXF-289 M2TROGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHTVVoNKSzVyPUCuNFI3PjhizszN NX3pSZNSW0GQR1XS
G-361 M4PZemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHv6XXVKSzVyPUCuNFI3PzdizszN NEn5R2VUSU6JRWK=
LB996-RCC MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1X4Z2lEPTB;MD6wNlcyKM7:TR?= Mn7KV2FPT0WU
COR-L23 M2H4Rmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGT4V|NKSzVyPUCuNFI4OTNizszN M3XhNnNCVkeHUh?=
GP5d M{HEfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV7HeY05UUN3ME2wMlAzPzJ|IN88US=> Ml\PV2FPT0WU
SW1990 MmLuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEja[GFKSzVyPUCuNFI4OjRizszN M{e0dnNCVkeHUh?=
PA-1 NXHFZZRVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHi4RWFKSzVyPUCuNFI4PTVizszN MXnTRW5ITVJ?
NCI-H2009 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXXJR|UxRTBwMEK3OkDPxE1? MUPTRW5ITVJ?
SR NGHoeohIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYLLNVl3UUN3ME2wMlAzPzh3IN88US=> M4DvVXNCVkeHUh?=
Ca9-22 M4rOcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH3re2xKSzVyPUCuNFI4QTZizszN MYHTRW5ITVJ?
SCC-15 Ml\KS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH\GeGpKSzVyPUCuNFI5ODFizszN NHvXSJFUSU6JRWK=
ETK-1 MmHOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mo\6TWM2OD1yLkCyPFA3KM7:TR?= NGT4ZnhUSU6JRWK=
SCC-4 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF;DVFNKSzVyPUCuNFI5ODlizszN MkC3V2FPT0WU
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SW962 MmTxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYrpOIxLUUN3ME2wMlAzQDV{IN88US=> MVjTRW5ITVJ?
HCE-T NYfzcXFxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2HrbWlEPTB;MD6wNlg3KM7:TR?= MnnhV2FPT0WU
NCI-H2405 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEW2dXNKSzVyPUCuNFI5QDdizszN M2rRSXNCVkeHUh?=
A2058 NYO1[GJRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYrJR|UxRTBwMEK5Nlkh|ryP NYK1cYpOW0GQR1XS
HCC2998 MnjVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXvVe4JDUUN3ME2wMlAzQTR3IN88US=> M{S0OnNCVkeHUh?=
ONS-76 NFzUeY9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYLkb5BqUUN3ME2wMlAzQTV2IN88US=> NUTUVXdEW0GQR1XS
DBTRG-05MG NIK4W2VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYrJR|UxRTBwMEK5OVUh|ryP M3PNUnNCVkeHUh?=
HuCCT1 NG\URo1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmTjTWM2OD1yLkCyPVYyKM7:TR?= MXHTRW5ITVJ?
J82 M2jk[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnHlTWM2OD1yLkCzNFA4KM7:TR?= MUnTRW5ITVJ?
MKN28 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4[wcWlEPTB;MD6wN|AyOiEQvF2= M2rmdXNCVkeHUh?=
SW837 M1LVbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXHuW5ZCUUN3ME2wMlA{ODF2IN88US=> NIXr[WdUSU6JRWK=
no-10 M2PYcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX3uZ21NUUN3ME2wMlA{ODF4IN88US=> MUnTRW5ITVJ?
BC-3 MnXqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXvWSIo{UUN3ME2wMlA{ODF6IN88US=> MoLqV2FPT0WU
no-11 Mn7HS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MY\JR|UxRTBwMEOwOFgh|ryP NWnIZ|Z6W0GQR1XS
8305C M2DEfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHjTepFKSzVyPUCuNFMxPzJizszN NHOyOnZUSU6JRWK=
COLO-679 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEGxSGdKSzVyPUCuNFMyODdizszN MljJV2FPT0WU
CESS NYm2cJBUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFf1RVBKSzVyPUCuNFMyOiEQvF2= NHT4c41USU6JRWK=
BFTC-909 M3;Lfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoXTTWM2OD1yLkCzNVI2KM7:TR?= MlPJV2FPT0WU
MZ2-MEL M3y2NWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYTJR|UxRTBwMEOxO|ch|ryP NIHUdWtUSU6JRWK=
SW872 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWTlN5FNUUN3ME2wMlA{OjF5IN88US=> NVzjfG0{W0GQR1XS
LB831-BLC MmfQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVOzU3pYUUN3ME2wMlA{OjF7IN88US=> M3nWc3NCVkeHUh?=
SK-UT-1 NU\LT5JPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVTJR|UxRTBwMEOyNlEh|ryP MljlV2FPT0WU
NCI-H1734 MmTYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3nBPGlEPTB;MD6wN|I{KM7:TR?= NVvaV|lIW0GQR1XS
OVCAR-8 NHvDeI5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIXZ[3dKSzVyPUCuNFMzQDFizszN NYHtWHE3W0GQR1XS
NCI-H2087 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEPlNo9KSzVyPUCuNFMzQDlizszN M{HpXHNCVkeHUh?=
U-87-MG MnnlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NInUNFhKSzVyPUCuNFMzQSEQvF2= NXXRfWxRW0GQR1XS
BC-1 Ml\CS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlzITWM2OD1yLkCzN|Y4KM7:TR?= NX7LPHRDW0GQR1XS
ES7 MmPDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYf2VIZiUUN3ME2wMlA{Ozd2IN88US=> MUnTRW5ITVJ?
Daudi NWn5dY5{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkHiTWM2OD1yLkCzN|c3KM7:TR?= M1TVPHNCVkeHUh?=
RS4-11 M3XqOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MknFTWM2OD1yLkCzN|g{KM7:TR?= NVPEdppHW0GQR1XS
JiyoyeP-2003 M{fGd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml3FTWM2OD1yLkCzN|g5KM7:TR?= M2jqVnNCVkeHUh?=
BL-70 NY\6WoFxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYTJR|UxRTBwMEOzPFkh|ryP NVOzTmN2W0GQR1XS
OS-RC-2 NVu5TVU2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHj3cW1KSzVyPUCuNFM{QTZizszN MVjTRW5ITVJ?
SF268 NES1SJpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4HWTWlEPTB;MD6wN|QxOSEQvF2= M1y1WnNCVkeHUh?=
BV-173 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX3PR4FDUUN3ME2wMlA{PDJ4IN88US=> NWDqd3AzW0GQR1XS
DMS-273 M4HWWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXLkU45lUUN3ME2wMlA{PDd7IN88US=> M1jZWXNCVkeHUh?=
22RV1 MlzqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEL4XoVKSzVyPUCuNFM2ODdizszN M1rnTHNCVkeHUh?=
ES8 NHPGWFRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnrGTWM2OD1yLkCzOVM5KM7:TR?= MYDTRW5ITVJ?
KYSE-150 NXfpb29IT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGftVppKSzVyPUCuNFM3ODhizszN NYfC[nRpW0GQR1XS
HCC1569 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGjHeHlKSzVyPUCuNFM3ODhizszN NULjbo1rW0GQR1XS
NB5 NIf5fXpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{i1eGlEPTB;MD6wN|YyOyEQvF2= MlLrV2FPT0WU
G-402 NWPJXGFHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYXJR|UxRTBwMEO2NVQh|ryP NIrXVFlUSU6JRWK=
NCI-H1693 NIDXUXFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGr0bmlKSzVyPUCuNFM3OTdizszN NGrtVWlUSU6JRWK=
LB2241-RCC M4XCSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHrkXnhKSzVyPUCuNFM3PDJizszN MWLTRW5ITVJ?
KP-4 MmjiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoqzTWM2OD1yLkCzOlY{KM7:TR?= MkixV2FPT0WU
ML-2 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYTyOIx{UUN3ME2wMlA{PjdzIN88US=> NWrFdW01W0GQR1XS
KU812 MkDES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWDQXHZEUUN3ME2wMlA{Pjh2IN88US=> MlvyV2FPT0WU
LS-411N MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXfHWnVQUUN3ME2wMlA{PzNzIN88US=> MYPTRW5ITVJ?
OAW-42 NIHRWpdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MorwTWM2OD1yLkCzO|Q4KM7:TR?= NVXuUGhGW0GQR1XS
HCC38 NGrWSmxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWDJR|UxRTBwMEO3O|Eh|ryP M17mSXNCVkeHUh?=
Ca-Ski NX75V2FyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MofLTWM2OD1yLkCzO|g1KM7:TR?= MmnxV2FPT0WU
Calu-3 NInvVWFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1vGfGlEPTB;MD6wN|c5QSEQvF2= NFrlc25USU6JRWK=
KYSE-70 MnXOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mlm4TWM2OD1yLkCzPFEzKM7:TR?= NUTCUY9nW0GQR1XS
D-392MG MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX7JR|UxRTBwMEO4OFIh|ryP MUnTRW5ITVJ?
OVCAR-4 M3zDZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYPmOpFbUUN3ME2wMlA{QDV6IN88US=> NXvzS5FLW0GQR1XS
Detroit562 M2\hNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXnMT45IUUN3ME2wMlA{QDd{IN88US=> M2P6WnNCVkeHUh?=
HEL NWfUbWw3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX3rcoxGUUN3ME2wMlA{QDlzIN88US=> M2e2XHNCVkeHUh?=
MONO-MAC-6 NIfSTIRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NE[zdppKSzVyPUCuNFM5QTNizszN NHjmc3VUSU6JRWK=
LoVo MkXzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MknVTWM2OD1yLkCzPVM{KM7:TR?= M4rLeXNCVkeHUh?=
U-2-OS MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV\JR|UxRTBwMEO5N|Uh|ryP MX\TRW5ITVJ?
A172 NGO0bmtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoXJTWM2OD1yLkCzPVUh|ryP NUjOeotiW0GQR1XS
OCUB-M M{\lPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH:yXHhKSzVyPUCuNFM6PjFizszN NYXCVnBbW0GQR1XS
SW48 NIPhR5hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV3JR|UxRTBwMESwN|Eh|ryP MorTV2FPT0WU
HC-1 M{Lse2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHjxWHFKSzVyPUCuNFQxPjlizszN M2X4cHNCVkeHUh?=
KOSC-2 Mn2xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlG1TWM2OD1yLkC0NVEh|ryP MmH5V2FPT0WU
HDLM-2 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX3JR|UxRTBwMESxNVQh|ryP NUfqdlZ4W0GQR1XS
CTV-1 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGCyfZZKSzVyPUCuNFQyOTZizszN MmX3V2FPT0WU
SH-4 M1PWSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGW3fmJKSzVyPUCuNFQyPDFizszN NXnYb5hsW0GQR1XS
SW756 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVTJR|UxRTBwMESxOVch|ryP NGHIblZUSU6JRWK=
GCT NVXhW5VpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmnyTWM2OD1yLkC0NVYyKM7:TR?= M4DVVXNCVkeHUh?=
CHL-1 NEXDWXZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYrJR|UxRTBwMESxOlkh|ryP M1\1R3NCVkeHUh?=
LAMA-84 NEDYXFNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoqxTWM2OD1yLkC0NVcyKM7:TR?= MoPKV2FPT0WU
LS-1034 MnXUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYjJR|UxRTBwMESxPVEh|ryP NXPMO4JSW0GQR1XS
NCI-H358 Mmn4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3T4O2lEPTB;MD6wOFIyOiEQvF2= M{nWU3NCVkeHUh?=
NB13 NWjmdYpHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXvNU5BRUUN3ME2wMlA1OjJ5IN88US=> MXrTRW5ITVJ?
TE-9 NFXBUWZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV7JR|UxRTBwMESyN|ch|ryP MoTYV2FPT0WU
OE33 M3HHSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmDOTWM2OD1yLkC0NlQyKM7:TR?= NUL0Z4NpW0GQR1XS
CAL-120 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV;EeWhqUUN3ME2wMlA1OjRzIN88US=> MXfTRW5ITVJ?
DJM-1 NH3uN|hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MljhTWM2OD1yLkC0NlczKM7:TR?= M3jNZnNCVkeHUh?=
SK-MEL-24 NIj4SmVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NULh[oxMUUN3ME2wMlA1Ojh|IN88US=> NFTuTWRUSU6JRWK=
VA-ES-BJ M3W4SGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnnUTWM2OD1yLkC0NlkzKM7:TR?= Mlj5V2FPT0WU
MMAC-SF NFzzN2tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVfFfmdNUUN3ME2wMlA1Ojl5IN88US=> NYjZUZRDW0GQR1XS
MZ7-mel NU\sSmdOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlzMTWM2OD1yLkC0N|Mh|ryP NYPvOpZnW0GQR1XS
BxPC-3 MkK1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYP2U4Y{UUN3ME2wMlA1OzRzIN88US=> MUjTRW5ITVJ?
HT-29 MkSyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmC4TWM2OD1yLkC0N|U4KM7:TR?= MlPiV2FPT0WU
SK-MEL-30 M{O0Wmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{X0U2lEPTB;MD6wOFM3OiEQvF2= NF7LVVZUSU6JRWK=
CAL-33 NFPxO3RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVfRSWJ{UUN3ME2wMlA1Ozd3IN88US=> MX7TRW5ITVJ?
COLO-680N M3PpWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYfJR|UxRTBwMES0NFch|ryP M3[wbXNCVkeHUh?=
NH-12 M4DYVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUHJR|UxRTBwMES0OEDPxE1? M4HYb3NCVkeHUh?=
HCC1937 Mn[3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWXJR|UxRTBwMES0OVYh|ryP MlyxV2FPT0WU
IMR-5 M4Gxe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3;LT2lEPTB;MD6wOFQ6KM7:TR?= NVv6[pd[W0GQR1XS
MC-CAR Ml;NS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXnVcpp2UUN3ME2wMlA1PTZ7IN88US=> NHLFXFBUSU6JRWK=
NCI-H747 NGW4SlNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGjHTo9KSzVyPUCuNFQ2PyEQvF2= NVjUWI1EW0GQR1XS
NCI-H1792 NUm1eHZ7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnX0TWM2OD1yLkC0OVgyKM7:TR?= NEjNT41USU6JRWK=
SW13 MnTXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NI\EOm1KSzVyPUCuNFQ2QSEQvF2= M33LfXNCVkeHUh?=
MLMA M4HWe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWTyRnZtUUN3ME2wMlA1PjB7IN88US=> NX\BW2VJW0GQR1XS
U251 MnvRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4qwdmlEPTB;MD6wOFc3OyEQvF2= MVnTRW5ITVJ?
U031 NVnTTpJrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYnldHJUUUN3ME2wMlA1PzdzIN88US=> NYToUXdVW0GQR1XS
ME-180 NFO0XHBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml3vTWM2OD1yLkC0O|gzKM7:TR?= M17u[XNCVkeHUh?=
SK-MEL-3 NU\4UJVJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnPBTWM2OD1yLkC0PFAzKM7:TR?= MW\TRW5ITVJ?
MOLT-4 M1fKemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYjJR|UxRTBwMES4NFMh|ryP M1TmfXNCVkeHUh?=
PF-382 M2PNUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{LZV2lEPTB;MD6wOFgzPiEQvF2= M4rt[HNCVkeHUh?=
NUGC-3 Ml;zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX3YTIR1UUN3ME2wMlA1QDJ5IN88US=> M{XNUXNCVkeHUh?=
NCI-H1417 NYnVWIVlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGnPXmJKSzVyPUCuNFQ5QSEQvF2= Mn7lV2FPT0WU
COLO-205 MoTPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmLmTWM2OD1yLkC0PVE6KM7:TR?= NH:wVZFUSU6JRWK=
TE-441-T M3\iNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1nu[WlEPTB;MD6wOFk{KM7:TR?= M4C5SnNCVkeHUh?=
MKN1 NHjCb2FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXnJR|UxRTBwMES5N{DPxE1? NIL3SIRUSU6JRWK=
UM-UC-3 NWDBVWtnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFTid3VKSzVyPUCuNFQ6PSEQvF2= NYqxW25kW0GQR1XS
SF126 NYLKdYQ3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{\oUmlEPTB;MD6wOVAyKM7:TR?= M4fYfHNCVkeHUh?=
LB1047-RCC M4LwZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4fE[mlEPTB;MD6wOVA{OSEQvF2= M1zL[nNCVkeHUh?=
A253 M1vBcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Moq3TWM2OD1yLkC1NFUzKM7:TR?= M2nWeHNCVkeHUh?=
NCI-H1963 M{L0NWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYOyO3A2UUN3ME2wMlA2OTd4IN88US=> Mn3SV2FPT0WU
VM-CUB-1 NYDT[VduT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3\DcmlEPTB;MD6wOVMyOSEQvF2= NWHUTWNTW0GQR1XS
T-24 M2TZVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX;6UmYzUUN3ME2wMlA2Ozh2IN88US=> NYfwRZM3W0GQR1XS
K-562 M{D4bGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXzJR|UxRTBwMEWzPFch|ryP NWTqPJVkW0GQR1XS
ARH-77 NIrZTG9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkW5TWM2OD1yLkC1N|k2KM7:TR?= NEXXO45USU6JRWK=
CA46 NEXOfXZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4fpVWlEPTB;MD6wOVQ{KM7:TR?= MkHSV2FPT0WU
HCC70 NYLjZ|lGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NG[xPY9KSzVyPUCuNFU1PTJizszN NYPRPWNUW0GQR1XS
ST486 M1jze2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIDi[HJKSzVyPUCuNFU2OjVizszN Mkj3V2FPT0WU
COLO-741 NXj3S4xGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3zqbWlEPTB;MD6wOVU{OSEQvF2= NWLiPXBvW0GQR1XS
SK-PN-DW MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEjMbFRKSzVyPUCuNFU2QDhizszN MVTTRW5ITVJ?
BL-41 NIjQOGFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVrJR|UxRTBwMEW1PVYh|ryP NXHMNIR5W0GQR1XS
D-263MG NIf1XllIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUfVSWtEUUN3ME2wMlA2Pjh|IN88US=> MlH5V2FPT0WU
KE-37 M2fsTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlLOTWM2OD1yLkC1Olg{KM7:TR?= MWPTRW5ITVJ?
LU-134-A NF64XJZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIKxSlZKSzVyPUCuNFU4OTVizszN Mn\tV2FPT0WU
HCC2157 M{fpT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnLPTWM2OD1yLkC1O|M{KM7:TR?= Mn7DV2FPT0WU
GAK MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVHJR|UxRTBwMEW3N|Qh|ryP MlziV2FPT0WU
IST-SL2 NWrOdGpwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1LpT2lEPTB;MD6wOVc1OyEQvF2= MYTTRW5ITVJ?
KMOE-2 MnHpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYTJR|UxRTBwMEW3OFkh|ryP MXPTRW5ITVJ?
SW1573 M1\i[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWHJR|UxRTBwMEW4NFIh|ryP M{njNXNCVkeHUh?=
SCC-9 NGr1SlFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1rrUGlEPTB;MD6wOVg4KM7:TR?= MmPzV2FPT0WU
MDA-MB-361 NFjUfFNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFm3bnFKSzVyPUCuNFU5PzJizszN M2H3e3NCVkeHUh?=
BHT-101 M4rrXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml36TWM2OD1yLkC1PFc3KM7:TR?= MnjVV2FPT0WU
NCI-H1770 MkDJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUHJR|UxRTBwMEW4O|kh|ryP NEGzUYZUSU6JRWK=
UACC-893 NYrDbnp3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYrJR|UxRTBwMEW4PVYh|ryP NV33OnIyW0GQR1XS
NCI-H226 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFL6XmtKSzVyPUCuNFU6QDhizszN MX3TRW5ITVJ?
HLE NXvNfFBbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mo[xTWM2OD1yLkC2NFgzKM7:TR?= NXjBeFVkW0GQR1XS
NCI-H1703 M1PpVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mlr3TWM2OD1yLkC2NVc5KM7:TR?= MonmV2FPT0WU
KURAMOCHI MnrBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGLsblNKSzVyPUCuNFYyQDlizszN MYLTRW5ITVJ?
RH-1 NHXVZ5hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUfJR|UxRTBwME[yN{DPxE1? MnrTV2FPT0WU
DSH1 NF22W2tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFq4WZJKSzVyPUCuNFYzPyEQvF2= NGHoNXFUSU6JRWK=
CAMA-1 Ml7rS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mm[3TWM2OD1yLkC2N|A{KM7:TR?= M{nUXXNCVkeHUh?=
NCI-H1437 NYTlZ3o{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHvUNHdKSzVyPUCuNFY{OjhizszN M1vTUHNCVkeHUh?=
HuP-T4 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWm3R5BNUUN3ME2wMlA3PTh4IN88US=> MYTTRW5ITVJ?
HCT-15 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{TRWWlEPTB;MD6wOlU6PyEQvF2= MVXTRW5ITVJ?
NCCIT MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{XqZmlEPTB;MD6wOlYxPCEQvF2= NWXlUpdHW0GQR1XS
BOKU M1LXdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUjJR|UxRTBwME[2O|Qh|ryP NGLZNm9USU6JRWK=
FADU Mn7iS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUnJR|UxRTBwME[3OFUh|ryP MoKwV2FPT0WU
SUP-T1 NX\Db4g2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIXwNWRKSzVyPUCuNFY4PiEQvF2= M2exOnNCVkeHUh?=
L-363 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIDaTlZKSzVyPUCuNFY6ODFizszN MVPTRW5ITVJ?
KNS-81-FD NISyPWxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIH5OWNKSzVyPUCuNFY6OThizszN NHi5WIhUSU6JRWK=
SU-DHL-1 NHqyWHBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3HoT2lEPTB;MD6wOlkzKM7:TR?= NHzW[HVUSU6JRWK=
HuH-7 NXftTZdQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXnkbHRDUUN3ME2wMlA4ODN3IN88US=> NWHidI5uW0GQR1XS
BT-474 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4nxW2lEPTB;MD6wO|A3OSEQvF2= NHjZWJpUSU6JRWK=
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MC116 MlKyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXPJR|UxRTJwM{[zPVch|ryP NYK2NGRNW0GQR1XS
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NCI-H889 NGjXeIhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWDJR|UxRTJwNU[3NFYh|ryP MVvTRW5ITVJ?
HT55 MmnhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoTzTWM2OD1{Lk[yNFE6KM7:TR?= NXPUOpBVW0GQR1XS
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MFM-223 M2XT[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2LBdWlEPTB;Mz6zOlA6PyEQvF2= M1nWbHNCVkeHUh?=
TE-5 NYj6OZRiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlnCTWM2OD12LkW2NVQ4KM7:TR?= MXjTRW5ITVJ?
NCI-H209 Mk\JS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEHnWJlKSzVyPUSuO|g2PzJizszN MXfTRW5ITVJ?
SiHa NXG2UIQ2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{H4fGlEPTB;ND65OVIxOyEQvF2= NHf3XGpUSU6JRWK=
NCI-H1395 NUe2T4Z1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXfYfo1YUUN3ME21MlExPjN|IN88US=> M2jZS3NCVkeHUh?=
A498 M{HQNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEfZOnZKSzVyPUWuNlEzPTFizszN M13qXHNCVkeHUh?=
ES5 M3jaV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mo\HTWM2OD13Lk[xNVc5KM7:TR?= NUTocGIzW0GQR1XS
MDA-MB-157 NGLIc2ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEPHe5pKSzVyPUWuOlY1PDNizszN M2\DNHNCVkeHUh?=
NCI-H1623 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mnf2TWM2OD13LkizOVU3KM7:TR?= NXjWdWZ7W0GQR1XS
RPMI-8866 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3zobmlEPTB;NT64OFc6OiEQvF2= M{XZdHNCVkeHUh?=
LC-1F NGXKc3NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH;ubJhKSzVyPU[uNFkzQTFizszN NIKwWVdUSU6JRWK=
TCCSUP NXv4eGJqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVO1PZJpUUN3ME22MlYxOzR7IN88US=> NWXoSVV{W0GQR1XS
TT NHHOeY9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoHkTWM2OD16LkOzNFA6KM7:TR?= MnPYV2FPT0WU
NCI-H1838 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUDJR|UxRThwNUG3N|Eh|ryP MoLPV2FPT0WU
NCI-H322M NIrVVHpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3ywRmlEPTB;OT6xOlI5OSEQvF2= MlfsV2FPT0WU
NCI-H187 MkLkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYnJR|UxRTlwNUG4N|Uh|ryP NYTvN3U2W0GQR1XS
SBC-1 Mm\qS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUjvdJU{UUN3ME25Mlk{PjV4IN88US=> MorSV2FPT0WU
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CPC-N MnK4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVfXXHJ2UUN3ME2xNU4xODdizszN NETFO|FUSU6JRWK=
TGBC24TKB NHXifppIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUTJR|UxRTF|LkWyPUDPxE1? NIrqUVBUSU6JRWK=
NCI-H2452 MojyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mnq1TWM2OD1zND63N{DPxE1? MV\TRW5ITVJ?
Hs-578-T MnH2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHrR[5NKSzVyPUG4MlU4PTlizszN NIXKeIxUSU6JRWK=
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NCI-H1563 M3\Qe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlX6TWM2OD1zOT63PFg5KM7:TR?= MX7TRW5ITVJ?
SW780 M4T4W2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGH4d5VKSzVyPUKxMlE{OThizszN NYezVGw5W0GQR1XS
NCI-H345 M2LVTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVnGV|dNUUN3ME2yNU45Pzd7IN88US=> MXTTRW5ITVJ?
LB771-HNC MmTvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIjJUJdKSzVyPUKyMlQ5OTNizszN Mke5V2FPT0WU
RT4 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoTuTWM2OD1{Mz6zNlgzKM7:TR?= NIT3fXRUSU6JRWK=
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NCI-H524 M3XiWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkK4TWM2OD1{ND6zPFEzKM7:TR?= M2PYUHNCVkeHUh?=
SNU-C1 NFrwS5BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFLCU3RKSzVyPUK0MlkyODVizszN NVnpZ4NJW0GQR1XS
NCI-SNU-16 MoT6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{jxcGlEPTB;NEiuN|E1OiEQvF2= NULDNVYxW0GQR1XS

... Click to View More Cell Line Experimental Data

In vivo Treatment with NVP-AUY922 causes a robust antitumor response and inhibits p-Akt and VEGF expression in an HSC-2 xenograft model. [2] In BT474, NVP-AUY922 shows complete loss of ERBB2 and substantial depletion of ERα, in addition to reductions in CDK4 and phospho-ERK1/2. [3]

Protocol

Kinase Assay:[3]
+ Expand

Kinase assay:

NVP-AUY922 is dissolved in DMSO at a concentration of 10 mM. NVP-AUY922 is assessed against HSP90α, HSP90β, GRP94, TRAP-1, HSP72, and topoisomerase II. Profiling against a panel of kinases has been carried out and screening against a panel of additional enzymes and receptors is performed at Cerep.
Cell Research:[1]
+ Expand
  • Cell lines: Human gastric cancer cells NCI-N87
  • Concentrations: 1 μM
  • Incubation Time: 3 days
  • Method: Human gastric cancer cells NCI-N87 (5-7 ×103 in 50 μL/well) are seeded in 96-well plates and incubated at 37 °C for 24 hours, followed by NVP-AUY922 treatment for 1-3 days at 37 °C. After treatment, the cells are assayed by MTT method and analyzed by microplate reader.
    (Only for Reference)
Animal Research:[3]
+ Expand
  • Animal Models: Female NCr athymic mice bearing WM266.4 human melanoma xenografts
  • Formulation: In DMSO and diluted in sterile saline/Tween 20
  • Dosages: 50 mg/kg
  • Administration: Administered via i.v. or i.p.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 93 mg/mL warmed (199.76 mM)
Ethanol 31 mg/mL (66.58 mM)
Water <1 mg/mL
In vivo 1% DMSO+30% polyethylene glycol+1% Tween 80 30 mg/mL

* 1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 465.54
Formula

C26H31N3O5

CAS No. 747412-49-3
Storage powder
in solvent
Synonyms VER-52296

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
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    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
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Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT01784640 Active, not recruiting Recurrent Non-small Cell Lung Cancer|Squamous Cell Lung Cancer|Stage IV Non-small Cell Lung Cancer Jonsson Comprehensive Cancer Center|National Cancer Institute (NCI) January 2014 Phase 1
NCT01922583 Active, not recruiting Non-small Cell Lung Cancer (NSCLC) National Taiwan University Hospital January 2014 Phase 2
NCT01854034 Active, not recruiting Non Small Cell Lung Cancer Massachusetts General Hospital July 2013 Phase 2
NCT01772797 Completed Anaplastic Lymphoma Kinase (ALK)|Non-small Cell Lung Cancer Novartis Pharmaceuticals|Novartis June 2013 Phase 1
NCT01752400 Active, not recruiting Non Small Cell Lung Cancer Massachusetts General Hospital January 2013 Phase 2
NCT01613950 Completed Stomach Neoplasms Esophageal Neoplasms Metastatic Gastric Cancer Mutated PI3KCA Protein Overexpressed HER2 Protein Novartis Pharmaceuticals|Novartis December 2012 Phase 1

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

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HSP (e.g. HSP90) Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID