Luminespib (AUY-922, NVP-AUY922)

Catalog No.S1069 Synonyms: VER-52296

Luminespib (AUY-922, NVP-AUY922) Chemical Structure

Molecular Weight(MW): 465.54

Luminespib (AUY-922, NVP-AUY922) is a highly potent HSP90 inhibitor for HSP90α/β with IC50 of 13 nM /21 nM in cell-free assays, weaker potency against the HSP90 family members GRP94 and TRAP-1, exhibits the tightest binding of any small-molecule HSP90 ligand. Phase 2.

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In DMSO USD 320 In stock
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USD 270 In stock
USD 470 In stock
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3 Customer Reviews

  • U2OS_exo cells were incubated with AUY922 for 20 h at the indicated concentrations before stimulation with TNFα (30 ng/mL) for 30 min and immunostaining to detect NF-κB (p65). DMSO 1%, cells stimulated by TNFα in the absence of AUY922. Representative pictures used to quantify nuclear and cytoplasmic localization of NF-κB.

    Proc Natl Acad Sci USA, 2014, 111(15): E1528–37 . Luminespib (AUY-922, NVP-AUY922) purchased from Selleck.

    J Biol Chem 2013 288(23), 16308-20. Luminespib (AUY-922, NVP-AUY922) purchased from Selleck.

  • Western blots show the molecular signature of HSP90 inhibition by NVP-AUY922  (ie, induction of HSP72 and depletion of client proteins such as ERBB2, CRAF and CDK4) in BT474 breast cancer cell line. GAPDH was used as loading control.

     

     

    2011 Dr. Swee Sharp and Professor Paul Workman from Cancer Research UK. Luminespib (AUY-922, NVP-AUY922) purchased from Selleck.

Purity & Quality Control

Choose Selective HSP (e.g. HSP90) Inhibitors

Biological Activity

Description Luminespib (AUY-922, NVP-AUY922) is a highly potent HSP90 inhibitor for HSP90α/β with IC50 of 13 nM /21 nM in cell-free assays, weaker potency against the HSP90 family members GRP94 and TRAP-1, exhibits the tightest binding of any small-molecule HSP90 ligand. Phase 2.
Targets
HSP90α [1]
(Cell-free assay)
HSP90β [1]
(Cell-free assay)
13 nM 21 nM
In vitro

NVP-AUY922 inhibits proliferation of various human cancer cell lines in vitro, with an average GI50 of 9 nM. [1] The IC50 values of NVP-AUY922 fall in the range of 2 to 40 nM in these gastric cancer cell lines. IC50 value for the BEAS-2B cells is 28.49 nM. Treatment with NVP-AUY922 does not influence the expression of HSP90, but expression of HSP70 gets elevated by NVP-AUY922 treatment. NVP-AUY922 increases the binding of HSP70 to HSP90. NVP-AUY922 causes p23 dissociation from the HSP90 complex and can then recruit HSP70 to the HSP90 complex. [1] After the treatment with NVP-AUY922, expression of receptor tyrosine kinases including VEGFR1, 2, 3 and PDGFRɑ is decreased. A decrease is also noticed in the expression of Akt and phospho-Akt. Meanwhile, treatment with NVP-AUY922 causes decreased expression of HER-2 in NCI-N87 cells. NVP-AUY922 treatment results in binding of HSP90 to client proteins and setting them up as targets for degradation by the proteasome. NVP-AUY922 can influence cell growth by affecting multiple signaling pathways. In addition, treatment with the proteasome inhibitor, MG132, restores expression of thymidylate synthase, which is decreased by NVP-AUY922. NVP-AUY922 increases the expression of cleaved caspase-3 leading to apoptosis in HSC-2 cells.[1]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
CMK NEjLdI9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NID3bnNKSzVyPUCuNFAxOTJ3IN88US=> M1PmTHNCVkeHUh?=
MV-4-11 NIrPT4ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmDITWM2OD1yLkCwNFU2QCEQvF2= MX3TRW5ITVJ?
NALM-6 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2O1dWlEPTB;MD6wNFA5PDJizszN NEDFRZhUSU6JRWK=
HOS NX61TmJtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX7CO3ppUUN3ME2wMlAxOTN6IN88US=> NITSZYZUSU6JRWK=
HT-144 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXnJR|UxRTBwMECxOVUh|ryP MoDPV2FPT0WU
SW1710 NFT1T29Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV3iU4tmUUN3ME2wMlAxOTh4IN88US=> M{LNR3NCVkeHUh?=
TE-8 Ml:4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mo\BTWM2OD1yLkCwNlM4KM7:TR?= M2jVeXNCVkeHUh?=
ES1 Mlf3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWTJR|UxRTBwMECyOlYh|ryP NWPzV5hCW0GQR1XS
CCF-STTG1 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NImxZ41KSzVyPUCuNFAzQTdizszN NWTKdoR6W0GQR1XS
PSN1 NVnofpZ5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3TkWWlEPTB;MD6wNFMyQCEQvF2= NWPzR3JyW0GQR1XS
CAL-51 MnuwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV;6R5dsUUN3ME2wMlAxOzJ3IN88US=> MYjTRW5ITVJ?
MCF7 NYDzfYVUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1z0UmlEPTB;MD6wNFM{PSEQvF2= M1PROHNCVkeHUh?=
SK-HEP-1 NYnCTZRpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX;JR|UxRTBwMECzN|Yh|ryP MmjDV2FPT0WU
LCLC-103H NG\USFhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkjHTWM2OD1yLkCwOFMh|ryP MUTTRW5ITVJ?
HMV-II MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYPJR|UxRTBwMEC0OFkh|ryP MoLRV2FPT0WU
MES-SA NFfqZYRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX2zXW1RUUN3ME2wMlAxPDV{IN88US=> M3jofHNCVkeHUh?=
SK-LMS-1 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHvOPHVKSzVyPUCuNFA1PThizszN MmD0V2FPT0WU
639-V NEXJbo5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnfYTWM2OD1yLkCwOFg2KM7:TR?= NE\XVYlUSU6JRWK=
SIG-M5 MlHvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUXLUGNkUUN3ME2wMlAxPDh7IN88US=> NEXTO41USU6JRWK=
LOUCY NICxdGlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUfJR|UxRTBwMEC1NFUh|ryP MWfTRW5ITVJ?
HSC-2 M1jC[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3TuW2lEPTB;MD6wNFUyQCEQvF2= M1fWUHNCVkeHUh?=
EW-13 NF;NOlZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYT3SXFqUUN3ME2wMlAxPTF6IN88US=> NIHSdYFUSU6JRWK=
RT-112 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnPCTWM2OD1yLkCwOVM2KM7:TR?= Mlv5V2FPT0WU
NKM-1 NVPqfWlET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmewTWM2OD1yLkCwOVQ4KM7:TR?= M3HWU3NCVkeHUh?=
KYSE-180 NGfmV4tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlvwTWM2OD1yLkCwOVg3KM7:TR?= M2q0bHNCVkeHUh?=
SW1783 NW\XXIlvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXTYb|gxUUN3ME2wMlAxPTlzIN88US=> NUHKR5ZYW0GQR1XS
A431 NYnybYh6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{nzPWlEPTB;MD6wNFYxPyEQvF2= MUTTRW5ITVJ?
SK-OV-3 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml22TWM2OD1yLkCwOlMh|ryP MnjuV2FPT0WU
RPMI-7951 NXvEUG1ET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mle5TWM2OD1yLkCwOlMyKM7:TR?= NYO1bHF3W0GQR1XS
Capan-2 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFTreVVKSzVyPUCuNFA3OzhizszN M173RnNCVkeHUh?=
HSC-3 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX7tW2o5UUN3ME2wMlAxPjRzIN88US=> M4TubnNCVkeHUh?=
786-0 MmPyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn;WTWM2OD1yLkCwOlY{KM7:TR?= MYHTRW5ITVJ?
Daoy MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYLlV2xRUUN3ME2wMlAxPjl3IN88US=> MoDPV2FPT0WU
KGN MlzRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIq5dopKSzVyPUCuNFA4ODNizszN MW\TRW5ITVJ?
EW-16 MoLWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M174e2lEPTB;MD6wNFc1QSEQvF2= NG[zeIVUSU6JRWK=
EW-7 NV7DNWZFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmDTTWM2OD1yLkCwO|U1KM7:TR?= NGOzNWdUSU6JRWK=
IGROV-1 MoC5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2HORmlEPTB;MD6wNFgyPCEQvF2= MWLTRW5ITVJ?
8505C MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWjJR|UxRTBwMEC4NlEh|ryP MljqV2FPT0WU
RKO M1nwNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXHHT3FqUUN3ME2wMlAxQDJ4IN88US=> NFnMVJlUSU6JRWK=
GDM-1 M37B[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3jiS2lEPTB;MD6wNFg1KM7:TR?= NULwRWxjW0GQR1XS
IST-MEL1 NWPqelFFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2PSTWlEPTB;MD6wNFg2OiEQvF2= NHHWOZhUSU6JRWK=
RPMI-6666 M2W5dmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF3tbFhKSzVyPUCuNFA5PTJizszN MXzTRW5ITVJ?
SNG-M M1jCRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYfJR|UxRTBwMEC4OVYh|ryP NY\CTnVKW0GQR1XS
KS-1 M4TVe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWXGVIRIUUN3ME2wMlAxQDV7IN88US=> NFfqd4dUSU6JRWK=
RXF393 M2foO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX36UnFRUUN3ME2wMlAxQDZizszN M3H4T3NCVkeHUh?=
CAL-12T NUHiZ4FuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{nsUWlEPTB;MD6wNFkzOiEQvF2= NVfWUWR5W0GQR1XS
BFTC-905 NHjCV4xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFLRS2VKSzVyPUCuNFA6OzhizszN MUfTRW5ITVJ?
SK-MES-1 NYfDWZE5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVjEd3ViUUN3ME2wMlAxQTR3IN88US=> MkDOV2FPT0WU
BB30-HNC NITFVWFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4XINGlEPTB;MD6wNFk2OiEQvF2= NX;XPZdPW0GQR1XS
AN3-CA M1;zbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWfmU3E2UUN3ME2wMlAyODF5IN88US=> MUjTRW5ITVJ?
EFO-27 NFm4OppIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4iw[2lEPTB;MD6wNVAyPyEQvF2= MUPTRW5ITVJ?
G-401 NXjvSHM5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnXlTWM2OD1yLkCxNFI2KM7:TR?= NXK1WmdMW0GQR1XS
BPH-1 MlH4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXH1ToNoUUN3ME2wMlAyODNizszN NHXQS3pUSU6JRWK=
NCI-H727 M1nXdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUC5V4g{UUN3ME2wMlAyODNizszN MnXHV2FPT0WU
SNU-423 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{K3TmlEPTB;MD6wNVA2OyEQvF2= NHzadmNUSU6JRWK=
KYSE-270 NIj3XW9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIXsfopKSzVyPUCuNFExPTlizszN NXvlU2VJW0GQR1XS
AGS MkXiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVrJR|UxRTBwMEGwOlEh|ryP M{T1XnNCVkeHUh?=
NCI-H2228 NVn0eZVRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1XLXmlEPTB;MD6wNVA3PCEQvF2= NEfm[GVUSU6JRWK=
SW954 NGHvcZhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH\MUJNKSzVyPUCuNFExPzFizszN MlLOV2FPT0WU
769-P MlK5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX;JR|UxRTBwMEGwO|Mh|ryP M3joc3NCVkeHUh?=
BB49-HNC M4jiPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUHYbldJUUN3ME2wMlAyODd5IN88US=> Ml\XV2FPT0WU
IA-LM M2q4cmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXzJR|UxRTBwMEGwPFYh|ryP MWfTRW5ITVJ?
NB69 NUPs[Fg4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2juSmlEPTB;MD6wNVExOiEQvF2= M3nmR3NCVkeHUh?=
C8166 M1m5UGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXzxW3VlUUN3ME2wMlAyOTJ7IN88US=> NV7qOpJwW0GQR1XS
NCI-H1299 NEDUTlFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV7Ud3pzUUN3ME2wMlAyOTV2IN88US=> NXzGTZI5W0GQR1XS
YKG-1 MlOzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml\GTWM2OD1yLkCxNVYh|ryP NGLxeHFUSU6JRWK=
PANC-03-27 M3\6Rmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXrHVHdIUUN3ME2wMlAyOTZ{IN88US=> MWPTRW5ITVJ?
YT NWT4UHYzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M17PWWlEPTB;MD6wNVE4QSEQvF2= NETSemVUSU6JRWK=
CAL-85-1 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnfUTWM2OD1yLkCxNVkzKM7:TR?= M{D1c3NCVkeHUh?=
GT3TKB Mln2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3vEemlEPTB;MD6wNVIxOiEQvF2= NXKwSmhZW0GQR1XS
BB65-RCC NUf6[YhTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4HUNmlEPTB;MD6wNVIxPCEQvF2= MXHTRW5ITVJ?
ES6 Mm\LS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml;QTWM2OD1yLkCxNlYyKM7:TR?= M4XsUXNCVkeHUh?=
MHH-ES-1 Mn;6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFjEZ3ZKSzVyPUCuNFEzPjNizszN MmqwV2FPT0WU
QIMR-WIL M3PJcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVjJR|UxRTBwMEGyOlkh|ryP M2TZZXNCVkeHUh?=
SNU-C2B NH:5SIFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2\RUmlEPTB;MD6wNVI4OiEQvF2= M{TOOnNCVkeHUh?=
OCI-AML2 M3LiN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWTJR|UxRTBwMEGyPFEh|ryP NF74O3BUSU6JRWK=
DU-145 NYXzWW4{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{D1dmlEPTB;MD6wNVI6KM7:TR?= M3Xx[3NCVkeHUh?=
SW982 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVHrbo1RUUN3ME2wMlAyOjl|IN88US=> M4X4NnNCVkeHUh?=
MFH-ino M2O3cGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUXY[oJDUUN3ME2wMlAyOjl|IN88US=> M{K5enNCVkeHUh?=
A427 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWLWfWhbUUN3ME2wMlAyOjl7IN88US=> NGewfFFUSU6JRWK=
LCLC-97TM1 M33EWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUXJR|UxRTBwMEGzJO69VQ>? MnnCV2FPT0WU
AM-38 M4Ta[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkLFTWM2OD1yLkCxN|AzKM7:TR?= NX3kR2poW0GQR1XS
K5 MmTuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUfJR|UxRTBwMEGzNFgh|ryP M1n4W3NCVkeHUh?=
T84 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVfxXVlqUUN3ME2wMlAyOzNzIN88US=> MnzsV2FPT0WU
TE-15 NGXJepJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1[2cGlEPTB;MD6wNVM{PiEQvF2= Ml7GV2FPT0WU
NCI-H460 NE\P[GtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1nSZ2lEPTB;MD6wNVM{PiEQvF2= NWLMdoJNW0GQR1XS
NTERA-S-cl-D1 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{L2dGlEPTB;MD6wNVM{QSEQvF2= NFn3[ohUSU6JRWK=
KYSE-450 NWLsb4N[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIPWVWNKSzVyPUCuNFE{PDlizszN MnTzV2FPT0WU
H4 M4jOO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4nGbGlEPTB;MD6wNVM3PiEQvF2= MU\TRW5ITVJ?
LC-2-ad MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVTJR|UxRTBwMEGzO{DPxE1? Mkf2V2FPT0WU
GAMG NWPHe4NbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXvJR|UxRTBwMEGzO|Eh|ryP M{TYcHNCVkeHUh?=
TK10 M2H1TWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXnJR|UxRTBwMEGzPFIh|ryP M1nIdXNCVkeHUh?=
NCI-H2122 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHryfItKSzVyPUCuNFE{QDRizszN M3HpSnNCVkeHUh?=
KM12 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWnEeG5xUUN3ME2wMlAyOzl7IN88US=> M3fIUXNCVkeHUh?=
CAL-39 NHv1fIlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoL2TWM2OD1yLkCxOFIh|ryP MYTTRW5ITVJ?
RPMI-2650 M4TGc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVvJR|UxRTBwMEG0N|Ih|ryP NESxVIFUSU6JRWK=
KYSE-510 NFzQO2ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NELyWlFKSzVyPUCuNFE1PDJizszN NWrYVWJsW0GQR1XS
KALS-1 NV3TUJh2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoThTWM2OD1yLkCxOFY3KM7:TR?= NYrySYw3W0GQR1XS
NCI-H1648 NXjLfnJnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX;JR|UxRTBwMEG0PVkh|ryP NFrmfnZUSU6JRWK=
ES4 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnnpTWM2OD1yLkCxOVAzKM7:TR?= MkLBV2FPT0WU
C-33-A M4jEPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmD4TWM2OD1yLkCxOVA6KM7:TR?= MnzhV2FPT0WU
MIA-PaCa-2 NHrUZWpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHXsRWdKSzVyPUCuNFE2ODlizszN NF[xZmVUSU6JRWK=
Becker NYfWT3FRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVqwN4FXUUN3ME2wMlAyPTF2IN88US=> NYC5fXc4W0GQR1XS
HOP-62 NFKxcHZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlPsTWM2OD1yLkCxOVQzKM7:TR?= NF7BR4dUSU6JRWK=
TE-1 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlHxTWM2OD1yLkCxOVgyKM7:TR?= NETIPXVUSU6JRWK=
KYSE-410 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlHBTWM2OD1yLkCxOVg3KM7:TR?= MWDTRW5ITVJ?
NOS-1 M{WyUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2P1XWlEPTB;MD6wNVU6OyEQvF2= MkD0V2FPT0WU
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BL-70 NEn5S|BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmPPTWM2OD1yLkCzN|g6KM7:TR?= MYjTRW5ITVJ?
OS-RC-2 NW\tcVNyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2O0RWlEPTB;MD6wN|M6PiEQvF2= MWDTRW5ITVJ?
SF268 M4PTVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnT2TWM2OD1yLkCzOFAyKM7:TR?= NHPkbnpUSU6JRWK=
BV-173 NFz1cVJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHfzWo1KSzVyPUCuNFM1OjZizszN NV3pXWxUW0GQR1XS
DMS-273 M4fxRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2foS2lEPTB;MD6wN|Q4QSEQvF2= M3jBTnNCVkeHUh?=
22RV1 MkDES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoLKTWM2OD1yLkCzOVA4KM7:TR?= MV;TRW5ITVJ?
ES8 NX\jeXdmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUHXcGNmUUN3ME2wMlA{PTN6IN88US=> MkTqV2FPT0WU
KYSE-150 NYPLTFFGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2jFSGlEPTB;MD6wN|YxQCEQvF2= NVHDPINIW0GQR1XS
HCC1569 NIjSdWNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGrZUJFKSzVyPUCuNFM3ODhizszN MmXZV2FPT0WU
NB5 NX7BXI57T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYPHe|FNUUN3ME2wMlA{PjF|IN88US=> MY\TRW5ITVJ?
G-402 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1jycmlEPTB;MD6wN|YyPCEQvF2= MWfTRW5ITVJ?
NCI-H1693 NYLRc3IxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIjl[2tKSzVyPUCuNFM3OTdizszN Mne4V2FPT0WU
LB2241-RCC MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIjCcIdKSzVyPUCuNFM3PDJizszN M4PiV3NCVkeHUh?=
KP-4 M1LkNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUPJR|UxRTBwMEO2OlMh|ryP NVHkNGs5W0GQR1XS
ML-2 NYftS5p4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mnv4TWM2OD1yLkCzOlcyKM7:TR?= NU\2ZphuW0GQR1XS
KU812 MlzvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXXJR|UxRTBwMEO2PFQh|ryP MlPPV2FPT0WU
LS-411N M4G0Z2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUi5OHNCUUN3ME2wMlA{PzNzIN88US=> MUfTRW5ITVJ?
OAW-42 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1SyeGlEPTB;MD6wN|c1PyEQvF2= NFfIbYxUSU6JRWK=
HCC38 M1vLU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFHRTopKSzVyPUCuNFM4PzFizszN NW\GTGdtW0GQR1XS
Ca-Ski M3T5cWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGfOdnVKSzVyPUCuNFM4QDRizszN NUnMbJlsW0GQR1XS
Calu-3 NEnaSldIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{PvdmlEPTB;MD6wN|c5QSEQvF2= NIXWcYtUSU6JRWK=
KYSE-70 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYC1ZpF6UUN3ME2wMlA{QDF{IN88US=> MXPTRW5ITVJ?
D-392MG M{DjVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYXJR|UxRTBwMEO4OFIh|ryP M1PmfXNCVkeHUh?=
OVCAR-4 NXnrd5ZWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVPJR|UxRTBwMEO4OVgh|ryP MnvQV2FPT0WU
Detroit562 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4XaUGlEPTB;MD6wN|g4OiEQvF2= NFLXdohUSU6JRWK=
HEL MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX;XeGJpUUN3ME2wMlA{QDlzIN88US=> NFPCeVhUSU6JRWK=
MONO-MAC-6 MkDMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1L1[WlEPTB;MD6wN|g6OyEQvF2= NGjGNI9USU6JRWK=
LoVo MmfYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXXJR|UxRTBwMEO5N|Mh|ryP MYrTRW5ITVJ?
U-2-OS NIHtV5JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn[1TWM2OD1yLkCzPVM2KM7:TR?= NVnjUGxDW0GQR1XS
A172 NU[3UWl7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnXjTWM2OD1yLkCzPVUh|ryP MmPZV2FPT0WU
OCUB-M M4fyRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NULwVpRyUUN3ME2wMlA{QTZzIN88US=> MnXIV2FPT0WU
SW48 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIi2fVBKSzVyPUCuNFQxOzFizszN MXPTRW5ITVJ?
HC-1 M4PydGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWDJR|UxRTBwMESwOlkh|ryP MorYV2FPT0WU
KOSC-2 MmfHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF7ScGpKSzVyPUCuNFQyOSEQvF2= MlLUV2FPT0WU
HDLM-2 M4HYe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHy4XZZKSzVyPUCuNFQyOTRizszN NITMRlZUSU6JRWK=
CTV-1 M{nidGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVTJR|UxRTBwMESxNVYh|ryP NYG4VGx4W0GQR1XS
SH-4 NYW3TG5IT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF;Ec5BKSzVyPUCuNFQyPDFizszN NWHKPFl2W0GQR1XS
SW756 NFvCU5NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3;TcWlEPTB;MD6wOFE2PyEQvF2= NGHLdVlUSU6JRWK=
GCT Mkj4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWG3NGFyUUN3ME2wMlA1OTZzIN88US=> NFvXW5lUSU6JRWK=
CHL-1 M{PXbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWnJR|UxRTBwMESxOlkh|ryP MVHTRW5ITVJ?
LAMA-84 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoraTWM2OD1yLkC0NVcyKM7:TR?= NXTpfll{W0GQR1XS
LS-1034 NF\SXFhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWK1O49WUUN3ME2wMlA1OTlzIN88US=> M2rzenNCVkeHUh?=
NCI-H358 M3v0XGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHXwRpNKSzVyPUCuNFQzOTJizszN NULORm5lW0GQR1XS
NB13 M37L[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHvm[2hKSzVyPUCuNFQzOjdizszN NVuzO5EzW0GQR1XS
TE-9 NV\mOIw5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHmyc4pKSzVyPUCuNFQzOzdizszN M{HG[3NCVkeHUh?=
OE33 M2nHU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHPEWXNKSzVyPUCuNFQzPDFizszN M1LvRXNCVkeHUh?=
CAL-120 NUPWNYh3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NI\EPG1KSzVyPUCuNFQzPDFizszN M2f2c3NCVkeHUh?=
DJM-1 NVzTbHBwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYrjVmlVUUN3ME2wMlA1Ojd{IN88US=> MUnTRW5ITVJ?
SK-MEL-24 MnL4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NILHN2xKSzVyPUCuNFQzQDNizszN M3TJfHNCVkeHUh?=
VA-ES-BJ MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYXJR|UxRTBwMESyPVIh|ryP NYL5UWJIW0GQR1XS
MMAC-SF MmnUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWD1OI5qUUN3ME2wMlA1Ojl5IN88US=> NGD4fZNUSU6JRWK=
MZ7-mel NGX2O2NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnvwTWM2OD1yLkC0N|Mh|ryP M1XreXNCVkeHUh?=
BxPC-3 NYmwW3AxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYHJR|UxRTBwMESzOFEh|ryP MVHTRW5ITVJ?
HT-29 NX7l[5dZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWLJR|UxRTBwMESzOVch|ryP M1fSVHNCVkeHUh?=
SK-MEL-30 NECyPWxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M120ZWlEPTB;MD6wOFM3OiEQvF2= NVixPYd{W0GQR1XS
CAL-33 NHrBSpNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NU\JNmtKUUN3ME2wMlA1Ozd3IN88US=> MlnLV2FPT0WU
COLO-680N NV76dY93T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1v3RmlEPTB;MD6wOFQxPyEQvF2= Mlr0V2FPT0WU
NH-12 NHjYS3NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIG3[FlKSzVyPUCuNFQ1PCEQvF2= M1Owc3NCVkeHUh?=
HCC1937 NVn0eoVlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmDoTWM2OD1yLkC0OFU3KM7:TR?= M2PXXXNCVkeHUh?=
IMR-5 NIDHWG1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYLJR|UxRTBwMES0PUDPxE1? NXKwb5Q1W0GQR1XS
MC-CAR MmK2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXrJR|UxRTBwMES1Olkh|ryP MnTkV2FPT0WU
NCI-H747 Mn3oS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1:0Z2lEPTB;MD6wOFU4KM7:TR?= NX3INFk1W0GQR1XS
NCI-H1792 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2G4c2lEPTB;MD6wOFU5OSEQvF2= NVnYNYo5W0GQR1XS
SW13 NFfnOGRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV;vNHVkUUN3ME2wMlA1PTlizszN MX;TRW5ITVJ?
MLMA M4Tk[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3P1NWlEPTB;MD6wOFYxQSEQvF2= MYLTRW5ITVJ?
U251 NFrrSHVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYXVOVhlUUN3ME2wMlA1PzZ|IN88US=> NVr4ZZRPW0GQR1XS
U031 M2\GWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mnn5TWM2OD1yLkC0O|cyKM7:TR?= MX;TRW5ITVJ?
ME-180 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIXTZYxKSzVyPUCuNFQ4QDJizszN MknVV2FPT0WU
SK-MEL-3 NHnpS|RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWPyXYVyUUN3ME2wMlA1QDB{IN88US=> MYDTRW5ITVJ?
MOLT-4 NVLkTVc3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYDYcHFYUUN3ME2wMlA1QDB|IN88US=> M{fPc3NCVkeHUh?=
PF-382 M2Syfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV;JR|UxRTBwMES4NlYh|ryP M121VnNCVkeHUh?=
NUGC-3 NYHJUI9RT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWXQTXE6UUN3ME2wMlA1QDJ5IN88US=> M1v1NnNCVkeHUh?=
NCI-H1417 M1u1OGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{XvUGlEPTB;MD6wOFg6KM7:TR?= NIjkU2RUSU6JRWK=
COLO-205 MljyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEjvfo9KSzVyPUCuNFQ6OTlizszN NUDTSYo1W0GQR1XS
TE-441-T M2ft[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYD6emtmUUN3ME2wMlA1QTNizszN NW\0colDW0GQR1XS
MKN1 M3z0cmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEPHWVdKSzVyPUCuNFQ6OyEQvF2= MmO0V2FPT0WU
UM-UC-3 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIO3bWtKSzVyPUCuNFQ6PSEQvF2= NFz6Z4JUSU6JRWK=
SF126 MoPPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MY\JR|UxRTBwMEWwNUDPxE1? MnHJV2FPT0WU
LB1047-RCC Mk\uS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmjHTWM2OD1yLkC1NFMyKM7:TR?= NWDCUYFDW0GQR1XS
A253 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1PaVWlEPTB;MD6wOVA2OiEQvF2= NEDXSWZUSU6JRWK=
NCI-H1963 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3PqPWlEPTB;MD6wOVE4PiEQvF2= MnTPV2FPT0WU
VM-CUB-1 M{XXZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIjZ[YpKSzVyPUCuNFU{OTFizszN NEjmZ3VUSU6JRWK=
T-24 NE\GZW5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2TGZWlEPTB;MD6wOVM5PCEQvF2= NE\0PGZUSU6JRWK=
K-562 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF7TVpNKSzVyPUCuNFU{QDdizszN MXrTRW5ITVJ?
ARH-77 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH;BS3RKSzVyPUCuNFU{QTVizszN NYjJeHFFW0GQR1XS
CA46 M1XJNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M37j[WlEPTB;MD6wOVQ{KM7:TR?= NYfzNnR5W0GQR1XS
HCC70 NGTRdGRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWHZXZc2UUN3ME2wMlA2PDV{IN88US=> NX7QOG5UW0GQR1XS
ST486 MnPGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MW\JR|UxRTBwMEW1NlUh|ryP M1fmNHNCVkeHUh?=
COLO-741 M4nKS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2SzNWlEPTB;MD6wOVU{OSEQvF2= MVfTRW5ITVJ?
SK-PN-DW MkHUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml;uTWM2OD1yLkC1OVg5KM7:TR?= NFTYXotUSU6JRWK=
BL-41 MnzXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVHJR|UxRTBwMEW1PVYh|ryP MmnvV2FPT0WU
D-263MG M1XSW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnP2TWM2OD1yLkC1Olg{KM7:TR?= M2fQNHNCVkeHUh?=
KE-37 NU\ab4dlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVTJR|UxRTBwMEW2PFMh|ryP NHnESoNUSU6JRWK=
LU-134-A NFm0d2ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUPJR|UxRTBwMEW3NVUh|ryP MmHwV2FPT0WU
HCC2157 MlvNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1rEemlEPTB;MD6wOVc{OyEQvF2= MYLTRW5ITVJ?
GAK NXS2NolGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkX6TWM2OD1yLkC1O|M1KM7:TR?= NGXJUXRUSU6JRWK=
IST-SL2 NFrKUGFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIfaWoFKSzVyPUCuNFU4PDNizszN NXzVdGNtW0GQR1XS
KMOE-2 NYLCfFd4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUHYd3hDUUN3ME2wMlA2PzR7IN88US=> M3ftRnNCVkeHUh?=
SW1573 NU\SUoU{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4LES2lEPTB;MD6wOVgxOiEQvF2= M{LadXNCVkeHUh?=
SCC-9 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MofWTWM2OD1yLkC1PFch|ryP MYfTRW5ITVJ?
MDA-MB-361 NYXIenlQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmXTTWM2OD1yLkC1PFczKM7:TR?= M4CwNnNCVkeHUh?=
BHT-101 MonoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mk\kTWM2OD1yLkC1PFc3KM7:TR?= NGX4ZoJUSU6JRWK=
NCI-H1770 NX64fmZ7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFjLO4xKSzVyPUCuNFU5PzlizszN MUTTRW5ITVJ?
UACC-893 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MULJR|UxRTBwMEW4PVYh|ryP M{DWZ3NCVkeHUh?=
NCI-H226 M2raPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWTJR|UxRTBwMEW5PFgh|ryP NVrL[lRvW0GQR1XS
HLE NWrBdGlET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NG\vZpRKSzVyPUCuNFYxQDJizszN MkPkV2FPT0WU
NCI-H1703 NVnWWXJST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV7OWJdLUUN3ME2wMlA3OTd6IN88US=> MXnTRW5ITVJ?
KURAMOCHI M4flVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYPJR|UxRTBwME[xPFkh|ryP M4LsVXNCVkeHUh?=
RH-1 NImweVlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{PiPGlEPTB;MD6wOlI{KM7:TR?= MVrTRW5ITVJ?
DSH1 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1nrSGlEPTB;MD6wOlI4KM7:TR?= NUf3PZU5W0GQR1XS
CAMA-1 NHfuS2JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4rOZWlEPTB;MD6wOlMxOyEQvF2= NVT1V|JYW0GQR1XS
NCI-H1437 NFjTUlVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYLpS3pNUUN3ME2wMlA3OzJ6IN88US=> M1fpcXNCVkeHUh?=
HuP-T4 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mne3TWM2OD1yLkC2OVg3KM7:TR?= MmPFV2FPT0WU
HCT-15 NXrST3B3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NG[xVWZKSzVyPUCuNFY2QTdizszN MYXTRW5ITVJ?
NCCIT M1ywUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlT5TWM2OD1yLkC2OlA1KM7:TR?= Ml3GV2FPT0WU
BOKU MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{\2VmlEPTB;MD6wOlY4PCEQvF2= NUHjZ3pKW0GQR1XS
FADU NE\U[WNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHu2V|BKSzVyPUCuNFY4PDVizszN M2LaPXNCVkeHUh?=
SUP-T1 NEO1W5ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUjJR|UxRTBwME[3OkDPxE1? M{jyUnNCVkeHUh?=
L-363 MoHuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoP3TWM2OD1yLkC2PVAyKM7:TR?= MWXTRW5ITVJ?
KNS-81-FD MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1fFS2lEPTB;MD6wOlkyQCEQvF2= NIq4N2pUSU6JRWK=
SU-DHL-1 NV3tfWpwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVHXRpNkUUN3ME2wMlA3QTJizszN NFP2PHhUSU6JRWK=
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NCI-H1581 NFLscVhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkmzTWM2OD1zLkO1Olg4KM7:TR?= MWPTRW5ITVJ?
NCI-H748 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUjJR|UxRTFwM{W3N|gh|ryP NGPUcI5USU6JRWK=
HCC1187 MoL5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYXwco5XUUN3ME2xMlU2PTJ{IN88US=> NWfYZooxW0GQR1XS
EoL-1-cell MonCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmTwTWM2OD1zLkW4PFg6KM7:TR?= MXPTRW5ITVJ?
HuO-3N1 NX7NW3RIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mlj5TWM2OD1zLkizOFEzKM7:TR?= NYTJWXB5W0GQR1XS
NCI-H1793 M1\Md2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnryTWM2OD1zLki3OVk{KM7:TR?= M4S0[XNCVkeHUh?=
Caov-3 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIL0NJlKSzVyPUKuNFA3OjVizszN MoS4V2FPT0WU
JAR MnS3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1\ZfWlEPTB;Mj6wO|kzKM7:TR?= NHfxd2NUSU6JRWK=
SK-MEL-28 NUHnR3gyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlPOTWM2OD1{LkG4NFk5KM7:TR?= MoruV2FPT0WU
EM-2 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmnuTWM2OD1{LkKwNlk{KM7:TR?= NX7CVIxYW0GQR1XS
Mewo M4LpVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M33mRmlEPTB;Mj6yNlI3PSEQvF2= NFrScVNUSU6JRWK=
NCI-H720 M4q4XGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVrrRWlLUUN3ME2yMlI3PTh3IN88US=> M2jRdXNCVkeHUh?=
CAL-54 M2PtNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1TSOGlEPTB;Mj6yOlc6PSEQvF2= NXLVNHJVW0GQR1XS
MC116 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFWzPHFKSzVyPUKuN|Y{QTdizszN M4rzXXNCVkeHUh?=
DG-75 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml;pTWM2OD1{LkS4OVc3KM7:TR?= NXvXV|dvW0GQR1XS
HCC1143 M3jpcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnLYTWM2OD1{LkWwOlU5KM7:TR?= NYSyW2VyW0GQR1XS
FTC-133 NFfjV45Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUXJR|UxRTJwNUO2PFkh|ryP M4XGZXNCVkeHUh?=
AsPC-1 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkfFTWM2OD1{LkWzPVI6KM7:TR?= MonUV2FPT0WU
NCI-H889 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVXJR|UxRTJwNU[3NFYh|ryP NX3GO2pbW0GQR1XS
HT55 M{jXVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWnh[VkxUUN3ME2yMlYzODF7IN88US=> NFfqbpVUSU6JRWK=
UMC-11 NVPWPZJXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4TyUmlEPTB;Mj63PFcyPSEQvF2= MV;TRW5ITVJ?
P12-ICHIKAWA M4\qTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnXETWM2OD1{LkiyNFQ3KM7:TR?= MlfPV2FPT0WU
HCC1395 M3L2UWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnfGTWM2OD1{Lkm4OlAzKM7:TR?= NGrCRmhUSU6JRWK=
D-283MED MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlfDTWM2OD1|LkG4PVM4KM7:TR?= MYfTRW5ITVJ?
COLO-800 MoXFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4XDdmlEPTB;Mz6zN|g6PyEQvF2= Mn;HV2FPT0WU
MFM-223 NFrncVJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmX4TWM2OD1|LkO2NFk4KM7:TR?= NEPje3hUSU6JRWK=
TE-5 M4W3Rmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVnJR|UxRTRwNU[xOFch|ryP NHm0fXVUSU6JRWK=
NCI-H209 M3f3dGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MofSTWM2OD12Lke4OVczKM7:TR?= NH;YR5ZUSU6JRWK=
SiHa NYS0eZV2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYPqfHVUUUN3ME20Mlk2OjB|IN88US=> Mn\wV2FPT0WU
NCI-H1395 NHLKc|RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnrjTWM2OD13LkGwOlM{KM7:TR?= MnqwV2FPT0WU
A498 NUTVXoV[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHq1cmFKSzVyPUWuNlEzPTFizszN NGi4[WVUSU6JRWK=
ES5 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlG3TWM2OD13Lk[xNVc5KM7:TR?= NYLHSXhQW0GQR1XS
MDA-MB-157 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGHtW3BKSzVyPUWuOlY1PDNizszN NW\qdXc6W0GQR1XS
NCI-H1623 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnPsTWM2OD13LkizOVU3KM7:TR?= NG\VemJUSU6JRWK=
RPMI-8866 Mk\vS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWnJWpo6UUN3ME21Mlg1Pzl{IN88US=> NGXxdmVUSU6JRWK=
LC-1F NVHJN2pKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWjEdHd7UUN3ME22MlA6OjlzIN88US=> MYfTRW5ITVJ?
TCCSUP M3HIbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEi1e2ZKSzVyPU[uOlA{PDlizszN NWW5VGxnW0GQR1XS
TT NXLXVJZvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoHFTWM2OD16LkOzNFA6KM7:TR?= MYTTRW5ITVJ?
NCI-H1838 NHzOTZRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{D4XGlEPTB;OD61NVc{OSEQvF2= M2DObnNCVkeHUh?=
NCI-H322M MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXXDRpBVUUN3ME25MlE3OjhzIN88US=> M2LkOnNCVkeHUh?=
NCI-H187 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mk[2TWM2OD17LkWxPFM2KM7:TR?= NWHQT4s{W0GQR1XS
SBC-1 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2DOe2lEPTB;OT65N|Y2PiEQvF2= M1jI[nNCVkeHUh?=
SCC-3 NWDPOXF2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIjlWmhKSzVyPUGwMlU3PzlizszN MnnlV2FPT0WU
SW948 NG[xcJBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUnJR|UxRTFyLke1NVEh|ryP Mmj2V2FPT0WU
CPC-N NUPJRoRYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mk\ITWM2OD1zMT6wNFch|ryP NXLoWWVjW0GQR1XS
TGBC24TKB MoDpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF\XVmZKSzVyPUGzMlUzQSEQvF2= M3HNVnNCVkeHUh?=
NCI-H2452 NFTsVoRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGf2WXZKSzVyPUG0Mlc{KM7:TR?= NEni[WlUSU6JRWK=
Hs-578-T MknSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXTPOIdTUUN3ME2xPE42PzV7IN88US=> NFflR3NUSU6JRWK=
DV-90 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkfnTWM2OD1zOD65PVQ2KM7:TR?= NHvuS2lUSU6JRWK=
NCI-H1563 NVrlVGtWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV\lWIViUUN3ME2xPU44QDh6IN88US=> M13FNHNCVkeHUh?=
SW780 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnjGTWM2OD1{MT6xN|E5KM7:TR?= NFjZXINUSU6JRWK=
NCI-H345 NUK1RlBYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkjkTWM2OD1{MT64O|c6KM7:TR?= NU[4dGRyW0GQR1XS
LB771-HNC NYniV|JWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4\mUGlEPTB;MkKuOFgyOyEQvF2= MVjTRW5ITVJ?
RT4 M3y1eWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml63TWM2OD1{Mz6zNlgzKM7:TR?= NIDiR4FUSU6JRWK=
NCI-H82 M3L5TGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFjlT5VKSzVyPUKzMlU2OjZizszN M1rLbHNCVkeHUh?=
NCI-H524 MlHTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGPoXI9KSzVyPUK0MlM5OTJizszN Ml\lV2FPT0WU
SNU-C1 M1[4cGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1vY[GlEPTB;MkSuPVExPSEQvF2= Mmq2V2FPT0WU
NCI-SNU-16 NFOxPVVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFf1Z49KSzVyPUS4MlMyPDJizszN MknEV2FPT0WU

... Click to View More Cell Line Experimental Data

In vivo Treatment with NVP-AUY922 causes a robust antitumor response and inhibits p-Akt and VEGF expression in an HSC-2 xenograft model. [2] In BT474, NVP-AUY922 shows complete loss of ERBB2 and substantial depletion of ERα, in addition to reductions in CDK4 and phospho-ERK1/2. [3]

Protocol

Kinase Assay:[3]
+ Expand

Kinase assay:

NVP-AUY922 is dissolved in DMSO at a concentration of 10 mM. NVP-AUY922 is assessed against HSP90α, HSP90β, GRP94, TRAP-1, HSP72, and topoisomerase II. Profiling against a panel of kinases has been carried out and screening against a panel of additional enzymes and receptors is performed at Cerep.
Cell Research:[1]
+ Expand
  • Cell lines: Human gastric cancer cells NCI-N87
  • Concentrations: 1 μM
  • Incubation Time: 3 days
  • Method: Human gastric cancer cells NCI-N87 (5-7 ×103 in 50 μL/well) are seeded in 96-well plates and incubated at 37 °C for 24 hours, followed by NVP-AUY922 treatment for 1-3 days at 37 °C. After treatment, the cells are assayed by MTT method and analyzed by microplate reader.
    (Only for Reference)
Animal Research:[3]
+ Expand
  • Animal Models: Female NCr athymic mice bearing WM266.4 human melanoma xenografts
  • Formulation: In DMSO and diluted in sterile saline/Tween 20
  • Dosages: 50 mg/kg
  • Administration: Administered via i.v. or i.p.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 93 mg/mL warmed (199.76 mM)
Ethanol 31 mg/mL (66.58 mM)
Water Insoluble
In vivo Add solvents individually and in order:
1% DMSO+30% polyethylene glycol+1% Tween 80
30 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 465.54
Formula

C26H31N3O5

CAS No. 747412-49-3
Storage powder
Synonyms VER-52296

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
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    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
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    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT01784640 Active, not recruiting Recurrent Non-small Cell Lung Cancer|Squamous Cell Lung Cancer|Stage IV Non-small Cell Lung Cancer Jonsson Comprehensive Cancer Center|National Cancer Institute (NCI) January 2014 Phase 1
NCT01922583 Active, not recruiting Non-small Cell Lung Cancer (NSCLC) National Taiwan University Hospital January 2014 Phase 2
NCT01854034 Active, not recruiting Non Small Cell Lung Cancer Massachusetts General Hospital July 2013 Phase 2
NCT01772797 Completed Anaplastic Lymphoma Kinase (ALK)|Non-small Cell Lung Cancer Novartis Pharmaceuticals|Novartis June 2013 Phase 1
NCT01752400 Active, not recruiting Non Small Cell Lung Cancer Massachusetts General Hospital January 2013 Phase 2
NCT01613950 Completed Stomach Neoplasms Esophageal Neoplasms Metastatic Gastric Cancer Mutated PI3KCA Protein Overexpressed HER2 Protein Novartis Pharmaceuticals|Novartis December 2012 Phase 1

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

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HSP (e.g. HSP90) Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID