Luminespib (AUY-922, NVP-AUY922)

Catalog No.S1069 Synonyms: VER-52296

Luminespib (AUY-922, NVP-AUY922) Chemical Structure

Molecular Weight(MW): 465.54

Luminespib (AUY-922, NVP-AUY922) is a highly potent HSP90 inhibitor for HSP90α/β with IC50 of 13 nM /21 nM in cell-free assays, weaker potency against the HSP90 family members GRP94 and TRAP-1, exhibits the tightest binding of any small-molecule HSP90 ligand. Phase 2.

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In DMSO USD 320 In stock
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3 Customer Reviews

  • U2OS_exo cells were incubated with AUY922 for 20 h at the indicated concentrations before stimulation with TNFα (30 ng/mL) for 30 min and immunostaining to detect NF-κB (p65). DMSO 1%, cells stimulated by TNFα in the absence of AUY922. Representative pictures used to quantify nuclear and cytoplasmic localization of NF-κB.

    Proc Natl Acad Sci USA, 2014, 111(15): E1528–37 . Luminespib (AUY-922, NVP-AUY922) purchased from Selleck.

    J Biol Chem 2013 288(23), 16308-20. Luminespib (AUY-922, NVP-AUY922) purchased from Selleck.

  • Western blots show the molecular signature of HSP90 inhibition by NVP-AUY922  (ie, induction of HSP72 and depletion of client proteins such as ERBB2, CRAF and CDK4) in BT474 breast cancer cell line. GAPDH was used as loading control.

     

     

    2011 Dr. Swee Sharp and Professor Paul Workman from Cancer Research UK. Luminespib (AUY-922, NVP-AUY922) purchased from Selleck.

Purity & Quality Control

Choose Selective HSP (e.g. HSP90) Inhibitors

Biological Activity

Description Luminespib (AUY-922, NVP-AUY922) is a highly potent HSP90 inhibitor for HSP90α/β with IC50 of 13 nM /21 nM in cell-free assays, weaker potency against the HSP90 family members GRP94 and TRAP-1, exhibits the tightest binding of any small-molecule HSP90 ligand. Phase 2.
Targets
HSP90α [1]
(Cell-free assay)
HSP90β [1]
(Cell-free assay)
13 nM 21 nM
In vitro

NVP-AUY922 inhibits proliferation of various human cancer cell lines in vitro, with an average GI50 of 9 nM. [1] The IC50 values of NVP-AUY922 fall in the range of 2 to 40 nM in these gastric cancer cell lines. IC50 value for the BEAS-2B cells is 28.49 nM. Treatment with NVP-AUY922 does not influence the expression of HSP90, but expression of HSP70 gets elevated by NVP-AUY922 treatment. NVP-AUY922 increases the binding of HSP70 to HSP90. NVP-AUY922 causes p23 dissociation from the HSP90 complex and can then recruit HSP70 to the HSP90 complex. [1] After the treatment with NVP-AUY922, expression of receptor tyrosine kinases including VEGFR1, 2, 3 and PDGFRɑ is decreased. A decrease is also noticed in the expression of Akt and phospho-Akt. Meanwhile, treatment with NVP-AUY922 causes decreased expression of HER-2 in NCI-N87 cells. NVP-AUY922 treatment results in binding of HSP90 to client proteins and setting them up as targets for degradation by the proteasome. NVP-AUY922 can influence cell growth by affecting multiple signaling pathways. In addition, treatment with the proteasome inhibitor, MG132, restores expression of thymidylate synthase, which is decreased by NVP-AUY922. NVP-AUY922 increases the expression of cleaved caspase-3 leading to apoptosis in HSC-2 cells.[1]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
CMK NFrnRplIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF:5cY1KSzVyPUCuNFAxOTJ3IN88US=> M1S2S3NCVkeHUh?=
MV-4-11 MojNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2\yOmlEPTB;MD6wNFA2PThizszN Mlj4V2FPT0WU
NALM-6 NFfLXZlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVPJR|UxRTBwMECwPFQzKM7:TR?= MlrwV2FPT0WU
HOS NHTYfI9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHu4OlJKSzVyPUCuNFAyOzhizszN MWXTRW5ITVJ?
HT-144 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH3ZSIdKSzVyPUCuNFAyPTVizszN NHXWeWhUSU6JRWK=
SW1710 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1rGOmlEPTB;MD6wNFE5PiEQvF2= NFzIeJdUSU6JRWK=
TE-8 M3j6N2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHP0THFKSzVyPUCuNFAzOzdizszN MnrLV2FPT0WU
ES1 NF\iVmxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVnQS4hpUUN3ME2wMlAxOjZ4IN88US=> MnPIV2FPT0WU
CCF-STTG1 NHTqOWxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGnIdHVKSzVyPUCuNFAzQTdizszN NH3xRWRUSU6JRWK=
PSN1 M1Lh[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3nMeWlEPTB;MD6wNFMyQCEQvF2= NYSxenRoW0GQR1XS
CAL-51 NIDYVZBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVHJR|UxRTBwMECzNlUh|ryP NILUVHpUSU6JRWK=
MCF7 NUezbWsyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXPEenB{UUN3ME2wMlAxOzN3IN88US=> NUGxdWdbW0GQR1XS
SK-HEP-1 M3LFZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGXZZWpKSzVyPUCuNFA{OzZizszN MVzTRW5ITVJ?
LCLC-103H MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2TKZmlEPTB;MD6wNFQ{KM7:TR?= NYLNfXRGW0GQR1XS
HMV-II M1v1VWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4XCUWlEPTB;MD6wNFQ1QSEQvF2= NYP4eJZyW0GQR1XS
MES-SA MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{HYc2lEPTB;MD6wNFQ2OiEQvF2= NV7ROpoyW0GQR1XS
SK-LMS-1 M1;Gfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYP4PJhQUUN3ME2wMlAxPDV6IN88US=> MnHtV2FPT0WU
639-V NUTH[Wc6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3riVGlEPTB;MD6wNFQ5PSEQvF2= NWTkeJd2W0GQR1XS
SIG-M5 NXGwRmZ7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MorGTWM2OD1yLkCwOFg6KM7:TR?= MYHTRW5ITVJ?
LOUCY MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn;PTWM2OD1yLkCwOVA2KM7:TR?= NIXxTWxUSU6JRWK=
HSC-2 NGfCdm9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXfJR|UxRTBwMEC1NVgh|ryP MmO5V2FPT0WU
EW-13 M1e3Nmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYDJR|UxRTBwMEC1NVgh|ryP NV\nZVcyW0GQR1XS
RT-112 NXLSOpRuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWrJR|UxRTBwMEC1N|Uh|ryP MoG5V2FPT0WU
NKM-1 M2myfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NG\6bHdKSzVyPUCuNFA2PDdizszN NHfVN3BUSU6JRWK=
KYSE-180 MmnMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVjJR|UxRTBwMEC1PFYh|ryP M1;OUnNCVkeHUh?=
SW1783 NVTEOmZLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnXnTWM2OD1yLkCwOVkyKM7:TR?= NWTweYVqW0GQR1XS
A431 M{X3PGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkfiTWM2OD1yLkCwOlA4KM7:TR?= NFvpcmRUSU6JRWK=
SK-OV-3 NV;tSpF4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUnJR|UxRTBwMEC2N{DPxE1? MlGzV2FPT0WU
RPMI-7951 Mle4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFTsZ2hKSzVyPUCuNFA3OzFizszN MVTTRW5ITVJ?
Capan-2 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{DrfGlEPTB;MD6wNFY{QCEQvF2= NFv3WVBUSU6JRWK=
HSC-3 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{PXdWlEPTB;MD6wNFY1OSEQvF2= M3ftZXNCVkeHUh?=
786-0 Mm\iS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX3YSYxlUUN3ME2wMlAxPjZ|IN88US=> NW[1TXFHW0GQR1XS
Daoy MlrQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkXETWM2OD1yLkCwOlk2KM7:TR?= Mor0V2FPT0WU
KGN MkLVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUnJR|UxRTBwMEC3NFMh|ryP MWDTRW5ITVJ?
EW-16 NWPMXm5jT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn;HTWM2OD1yLkCwO|Q6KM7:TR?= MXjTRW5ITVJ?
EW-7 NEXIcHZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NE[3em5KSzVyPUCuNFA4PTRizszN NYm0[2dKW0GQR1XS
IGROV-1 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3zVc2lEPTB;MD6wNFgyPCEQvF2= M16zXHNCVkeHUh?=
8505C NVrzXXZQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2\GUWlEPTB;MD6wNFgzOSEQvF2= MnTCV2FPT0WU
RKO NHLZOFZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn3VTWM2OD1yLkCwPFI3KM7:TR?= NV;4cVdIW0GQR1XS
GDM-1 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoXhTWM2OD1yLkCwPFQh|ryP MV7TRW5ITVJ?
IST-MEL1 NXzoWnlzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXG3U2dmUUN3ME2wMlAxQDV{IN88US=> MXjTRW5ITVJ?
RPMI-6666 MmrpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M32z[GlEPTB;MD6wNFg2OiEQvF2= M2rnfXNCVkeHUh?=
SNG-M Ml;aS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGTST5JKSzVyPUCuNFA5PTZizszN NHzmU4dUSU6JRWK=
KS-1 NGPlfmxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlLGTWM2OD1yLkCwPFU6KM7:TR?= NULKcJF1W0GQR1XS
RXF393 M2D1bWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIn0SGxKSzVyPUCuNFA5PiEQvF2= M1vBWHNCVkeHUh?=
CAL-12T MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXrJR|UxRTBwMEC5NlIh|ryP NEHHUpBUSU6JRWK=
BFTC-905 NUTmeWVYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXPJR|UxRTBwMEC5N|gh|ryP NVfZR2hmW0GQR1XS
SK-MES-1 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF;YVGNKSzVyPUCuNFA6PDVizszN MWfTRW5ITVJ?
BB30-HNC MmjtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NU\s[29QUUN3ME2wMlAxQTV{IN88US=> NEPUZ49USU6JRWK=
AN3-CA M4DUR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWjPTG9EUUN3ME2wMlAyODF5IN88US=> MoXnV2FPT0WU
EFO-27 M4LPUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXzJR|UxRTBwMEGwNVch|ryP NG[wR5hUSU6JRWK=
G-401 M4\4UGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWLaO5ZMUUN3ME2wMlAyODJ3IN88US=> NWexcYN1W0GQR1XS
BPH-1 NXLTT4tqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVHCVVFOUUN3ME2wMlAyODNizszN NYTLeGk3W0GQR1XS
NCI-H727 NGm0fFNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIradlVKSzVyPUCuNFExOyEQvF2= M1Xo[3NCVkeHUh?=
SNU-423 NX;veGdOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVLY[nRPUUN3ME2wMlAyODV|IN88US=> M{XHbnNCVkeHUh?=
KYSE-270 NH[5fpZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkHRTWM2OD1yLkCxNFU6KM7:TR?= MXnTRW5ITVJ?
AGS Mmf5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4faS2lEPTB;MD6wNVA3OSEQvF2= MlrLV2FPT0WU
NCI-H2228 NXLnfYVQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkDLTWM2OD1yLkCxNFY1KM7:TR?= M2nlWXNCVkeHUh?=
SW954 MnXPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MonvTWM2OD1yLkCxNFcyKM7:TR?= M{XEXXNCVkeHUh?=
769-P NEXw[GZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEDjelhKSzVyPUCuNFExPzNizszN NWHkOm1[W0GQR1XS
BB49-HNC NX7TbJpHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkPxTWM2OD1yLkCxNFc4KM7:TR?= NGfGe4xUSU6JRWK=
IA-LM M{\PXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkfETWM2OD1yLkCxNFg3KM7:TR?= MmSxV2FPT0WU
NB69 NU[xWpROT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1r6dmlEPTB;MD6wNVExOiEQvF2= NEL5cGhUSU6JRWK=
C8166 M{T6e2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEC0bVFKSzVyPUCuNFEyOjlizszN NYXZZWd1W0GQR1XS
NCI-H1299 NGP0NZZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mlv4TWM2OD1yLkCxNVU1KM7:TR?= MlrqV2FPT0WU
YKG-1 NXvzeHNCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX\5R4ZNUUN3ME2wMlAyOTZizszN NFfDNGdUSU6JRWK=
PANC-03-27 M{PVcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXHtNHpnUUN3ME2wMlAyOTZ{IN88US=> NYTUU2NzW0GQR1XS
YT MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIq3S|dKSzVyPUCuNFEyPzlizszN NV7JdFh2W0GQR1XS
CAL-85-1 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVPJR|UxRTBwMEGxPVIh|ryP M3PLR3NCVkeHUh?=
GT3TKB MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFP3e5NKSzVyPUCuNFEzODJizszN M1vRSXNCVkeHUh?=
BB65-RCC MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mk\jTWM2OD1yLkCxNlA1KM7:TR?= MV\TRW5ITVJ?
ES6 NFnwXIpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYnJR|UxRTBwMEGyOlEh|ryP MmfzV2FPT0WU
MHH-ES-1 MmDMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFWyZlRKSzVyPUCuNFEzPjNizszN NF3FfXFUSU6JRWK=
QIMR-WIL NUXxeHd2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MorFTWM2OD1yLkCxNlY6KM7:TR?= NGe1TmFUSU6JRWK=
SNU-C2B NXzJRnpkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mkm0TWM2OD1yLkCxNlczKM7:TR?= Moj6V2FPT0WU
OCI-AML2 MmTjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NETRSG5KSzVyPUCuNFEzQDFizszN MV3TRW5ITVJ?
DU-145 NHzVcJpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlTBTWM2OD1yLkCxNlkh|ryP MnXXV2FPT0WU
SW982 MnPNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUTJR|UxRTBwMEGyPVMh|ryP M1fFR3NCVkeHUh?=
MFH-ino NXG1RZBNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4ryRmlEPTB;MD6wNVI6OyEQvF2= M3K4THNCVkeHUh?=
A427 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mmn6TWM2OD1yLkCxNlk6KM7:TR?= MmD5V2FPT0WU
LCLC-97TM1 NXfifZduT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnPFTWM2OD1yLkCxN{DPxE1? NWfK[|BlW0GQR1XS
AM-38 NHnEbYhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3f4XGlEPTB;MD6wNVMxOiEQvF2= MWnTRW5ITVJ?
K5 M1eyfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4W4N2lEPTB;MD6wNVMxQCEQvF2= NEfxO3pUSU6JRWK=
T84 NWnseWV[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M17pR2lEPTB;MD6wNVM{OSEQvF2= MX7TRW5ITVJ?
TE-15 M{\XXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVHJR|UxRTBwMEGzN|Yh|ryP NFLOPI5USU6JRWK=
NCI-H460 MmWxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3:xemlEPTB;MD6wNVM{PiEQvF2= MYjTRW5ITVJ?
NTERA-S-cl-D1 NYP6W4E{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3\lSWlEPTB;MD6wNVM{QSEQvF2= NXriToFlW0GQR1XS
KYSE-450 NEHkT3pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXXoNZpnUUN3ME2wMlAyOzR7IN88US=> MlfmV2FPT0WU
H4 M2\xdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX7XNJZZUUN3ME2wMlAyOzZ4IN88US=> M1LVbHNCVkeHUh?=
LC-2-ad NEnnRlZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV2zdFdkUUN3ME2wMlAyOzdizszN M3vkXnNCVkeHUh?=
GAMG NVy3RVd5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGfubGpKSzVyPUCuNFE{PzFizszN NFvKTnNUSU6JRWK=
TK10 NV\xWWdwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4n6XGlEPTB;MD6wNVM5OiEQvF2= M2Xh[XNCVkeHUh?=
NCI-H2122 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3nCbmlEPTB;MD6wNVM5PCEQvF2= Mm\IV2FPT0WU
KM12 NHT6enFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVPJR|UxRTBwMEGzPVkh|ryP NWf3NGJuW0GQR1XS
CAL-39 M{X5cmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NG\kXFBKSzVyPUCuNFE1OiEQvF2= NV7m[VFRW0GQR1XS
RPMI-2650 NILpOYZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGX4SHhKSzVyPUCuNFE1OzJizszN NGi5cZpUSU6JRWK=
KYSE-510 NES4b4lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYrJR|UxRTBwMEG0OFIh|ryP NYDoN4k3W0GQR1XS
KALS-1 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHnsWopKSzVyPUCuNFE1PjZizszN NG\WV|JUSU6JRWK=
NCI-H1648 M4XETmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIjjNnRKSzVyPUCuNFE1QTlizszN M{jtWXNCVkeHUh?=
ES4 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4SzWGlEPTB;MD6wNVUxOiEQvF2= NYnHTmpIW0GQR1XS
C-33-A NWHqXoE5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF7zbZpKSzVyPUCuNFE2ODlizszN NHnCVFBUSU6JRWK=
MIA-PaCa-2 NFnLfm5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXLJR|UxRTBwMEG1NFkh|ryP M{DYUnNCVkeHUh?=
Becker MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEXkPJdKSzVyPUCuNFE2OTRizszN NV;E[mxiW0GQR1XS
HOP-62 M3jDR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4TzSmlEPTB;MD6wNVU1OiEQvF2= NE\1RWRUSU6JRWK=
TE-1 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFfCZmxKSzVyPUCuNFE2QDFizszN NUjaSI5VW0GQR1XS
KYSE-410 M1fve2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnHvTWM2OD1yLkCxOVg3KM7:TR?= MkfmV2FPT0WU
NOS-1 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn\CTWM2OD1yLkCxOVk{KM7:TR?= Mo\nV2FPT0WU
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BL-70 NEfKUmxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml;MTWM2OD1yLkCzN|g6KM7:TR?= MnTLV2FPT0WU
OS-RC-2 M3fDXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3TncWlEPTB;MD6wN|M6PiEQvF2= NYW0O49vW0GQR1XS
SF268 NULyfZBNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGLLTZpKSzVyPUCuNFM1ODFizszN MWfTRW5ITVJ?
BV-173 NFfObY5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVO1PWNwUUN3ME2wMlA{PDJ4IN88US=> M4ribnNCVkeHUh?=
DMS-273 NXnvc25IT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUPJR|UxRTBwMEO0O|kh|ryP MnG2V2FPT0WU
22RV1 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml3PTWM2OD1yLkCzOVA4KM7:TR?= NFywR41USU6JRWK=
ES8 M4nnR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFPZeI9KSzVyPUCuNFM2OzhizszN MWrTRW5ITVJ?
KYSE-150 M{PEVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXLJR|UxRTBwMEO2NFgh|ryP M2PtfHNCVkeHUh?=
HCC1569 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWrJR|UxRTBwMEO2NFgh|ryP Mk\PV2FPT0WU
NB5 M3m3fGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn2wTWM2OD1yLkCzOlE{KM7:TR?= M2rmOHNCVkeHUh?=
G-402 MoW2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MofjTWM2OD1yLkCzOlE1KM7:TR?= MlPPV2FPT0WU
NCI-H1693 NVuwUlRFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mor6TWM2OD1yLkCzOlE4KM7:TR?= MX3TRW5ITVJ?
LB2241-RCC M4j1UWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEPK[2pKSzVyPUCuNFM3PDJizszN M17r[3NCVkeHUh?=
KP-4 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVzJR|UxRTBwMEO2OlMh|ryP MnrxV2FPT0WU
ML-2 M{DkeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVPPRmtvUUN3ME2wMlA{PjdzIN88US=> MVHTRW5ITVJ?
KU812 M1TzR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2XWV2lEPTB;MD6wN|Y5PCEQvF2= NEW5TJZUSU6JRWK=
LS-411N MmrqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX\nNJpLUUN3ME2wMlA{PzNzIN88US=> NUXPcVFTW0GQR1XS
OAW-42 NVT5d2FZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVLJR|UxRTBwMEO3OFch|ryP M{T0W3NCVkeHUh?=
HCC38 NIP2d2pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVrJR|UxRTBwMEO3O|Eh|ryP MVHTRW5ITVJ?
Ca-Ski MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3LySmlEPTB;MD6wN|c5PCEQvF2= M3;hSnNCVkeHUh?=
Calu-3 M1z4N2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4XXcmlEPTB;MD6wN|c5QSEQvF2= Mkj1V2FPT0WU
KYSE-70 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWDQZ29SUUN3ME2wMlA{QDF{IN88US=> MV7TRW5ITVJ?
D-392MG MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX\RcolmUUN3ME2wMlA{QDR{IN88US=> Mn7oV2FPT0WU
OVCAR-4 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVPtV2xnUUN3ME2wMlA{QDV6IN88US=> M3XFXXNCVkeHUh?=
Detroit562 NHfmeHlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnzWTWM2OD1yLkCzPFczKM7:TR?= MnfzV2FPT0WU
HEL NWDleHV3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1vWR2lEPTB;MD6wN|g6OSEQvF2= MX3TRW5ITVJ?
MONO-MAC-6 M4LTdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1y2VmlEPTB;MD6wN|g6OyEQvF2= MlrmV2FPT0WU
LoVo NXvpOIFTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH\WVo1KSzVyPUCuNFM6OzNizszN NHLhWWtUSU6JRWK=
U-2-OS NVr1NJN6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlnZTWM2OD1yLkCzPVM2KM7:TR?= M1TuU3NCVkeHUh?=
A172 NWq1R29CT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3XPemlEPTB;MD6wN|k2KM7:TR?= M1rFSnNCVkeHUh?=
OCUB-M NVnJS3FyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEjVOXlKSzVyPUCuNFM6PjFizszN M2[3[3NCVkeHUh?=
SW48 MoPnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH;oeVlKSzVyPUCuNFQxOzFizszN MUjTRW5ITVJ?
HC-1 MojqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3LmVmlEPTB;MD6wOFA3QSEQvF2= NU[3NnJRW0GQR1XS
KOSC-2 MknRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVXWT5lbUUN3ME2wMlA1OTFizszN NYiwNYl6W0GQR1XS
HDLM-2 NUT3N5ZzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWrJR|UxRTBwMESxNVQh|ryP MWfTRW5ITVJ?
CTV-1 MmjVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWfJR|UxRTBwMESxNVYh|ryP M1XVTXNCVkeHUh?=
SH-4 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXvJR|UxRTBwMESxOFEh|ryP MXHTRW5ITVJ?
SW756 M{myUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIXIcmdKSzVyPUCuNFQyPTdizszN NHvUd2tUSU6JRWK=
GCT M2LQRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFHzZVRKSzVyPUCuNFQyPjFizszN M2fpWHNCVkeHUh?=
CHL-1 NEfyc|BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXXLfVVZUUN3ME2wMlA1OTZ7IN88US=> NXXWfG1CW0GQR1XS
LAMA-84 NUfaNIZMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4W1b2lEPTB;MD6wOFE4OSEQvF2= MUDTRW5ITVJ?
LS-1034 NGDsb4VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NETHfI9KSzVyPUCuNFQyQTFizszN MmHLV2FPT0WU
NCI-H358 NYjzS2xRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmO2TWM2OD1yLkC0NlEzKM7:TR?= NIKwbINUSU6JRWK=
NB13 NEDNbGVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWfJR|UxRTBwMESyNlch|ryP NWjPUZhlW0GQR1XS
TE-9 NHTPZpNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYDxflc6UUN3ME2wMlA1OjN5IN88US=> MnzuV2FPT0WU
OE33 NHP4cllIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mo\MTWM2OD1yLkC0NlQyKM7:TR?= NI[yR4pUSU6JRWK=
CAL-120 NYO1R21YT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmXxTWM2OD1yLkC0NlQyKM7:TR?= MW\TRW5ITVJ?
DJM-1 M3TRbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2\ZUmlEPTB;MD6wOFI4OiEQvF2= NI\ROppUSU6JRWK=
SK-MEL-24 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHHKZ25KSzVyPUCuNFQzQDNizszN NXnBSpRXW0GQR1XS
VA-ES-BJ MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWfJR|UxRTBwMESyPVIh|ryP NVey[G1KW0GQR1XS
MMAC-SF MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkOxTWM2OD1yLkC0Nlk4KM7:TR?= MojQV2FPT0WU
MZ7-mel M3\jPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXTJR|UxRTBwMESzN{DPxE1? NWO3dng{W0GQR1XS
BxPC-3 M1K5Smdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGqxbJlKSzVyPUCuNFQ{PDFizszN MXXTRW5ITVJ?
HT-29 NUPOV45uT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYTJR|UxRTBwMESzOVch|ryP NWLPTm9FW0GQR1XS
SK-MEL-30 NVPXbVNqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MknuTWM2OD1yLkC0N|YzKM7:TR?= MoLCV2FPT0WU
CAL-33 M{\B[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2LScmlEPTB;MD6wOFM4PSEQvF2= MoTFV2FPT0WU
COLO-680N NHfhPJhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHnod49KSzVyPUCuNFQ1ODdizszN MlOxV2FPT0WU
NH-12 M4exdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUXFUXE6UUN3ME2wMlA1PDRizszN NX7xdHA3W0GQR1XS
HCC1937 NUnDTZBtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV3JR|UxRTBwMES0OVYh|ryP M2KyVnNCVkeHUh?=
IMR-5 NYS4c|RIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEjIZ4RKSzVyPUCuNFQ1QSEQvF2= MYPTRW5ITVJ?
MC-CAR MlPTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWTJR|UxRTBwMES1Olkh|ryP NGWzU4dUSU6JRWK=
NCI-H747 NUDHSZNZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEHRU2JKSzVyPUCuNFQ2PyEQvF2= NGLQN5JUSU6JRWK=
NCI-H1792 NITwUY1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVW1T4xQUUN3ME2wMlA1PThzIN88US=> M2juNXNCVkeHUh?=
SW13 M2LBe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEWzZW5KSzVyPUCuNFQ2QSEQvF2= NUPFfnF3W0GQR1XS
MLMA MnPCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoWzTWM2OD1yLkC0OlA6KM7:TR?= NFHyeVhUSU6JRWK=
U251 NVLzNFJ1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUDJR|UxRTBwMES3OlMh|ryP M171V3NCVkeHUh?=
U031 Mn\wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4LMPWlEPTB;MD6wOFc4OSEQvF2= NGfOSWNUSU6JRWK=
ME-180 MnfES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH3UTG5KSzVyPUCuNFQ4QDJizszN NVvMWpFDW0GQR1XS
SK-MEL-3 NEn4NmFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYrMeoFyUUN3ME2wMlA1QDB{IN88US=> MUTTRW5ITVJ?
MOLT-4 M{TDfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoHsTWM2OD1yLkC0PFA{KM7:TR?= NHfW[|RUSU6JRWK=
PF-382 NIm2N3JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4HuW2lEPTB;MD6wOFgzPiEQvF2= NWKyNG41W0GQR1XS
NUGC-3 MoTCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEfkXI1KSzVyPUCuNFQ5OjdizszN M2jhPHNCVkeHUh?=
NCI-H1417 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGrEd5JKSzVyPUCuNFQ5QSEQvF2= NX\QU3p2W0GQR1XS
COLO-205 M2DTS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEfSe|RKSzVyPUCuNFQ6OTlizszN MmTvV2FPT0WU
TE-441-T MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV7JR|UxRTBwMES5N{DPxE1? M3jYdnNCVkeHUh?=
MKN1 M2f4Tmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGXMSmZKSzVyPUCuNFQ6OyEQvF2= NWLUUnhzW0GQR1XS
UM-UC-3 NHj6N4pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4fzVWlEPTB;MD6wOFk2KM7:TR?= NVe0[YkyW0GQR1XS
SF126 M1fGc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NW\PbIY5UUN3ME2wMlA2ODFizszN M3fKWnNCVkeHUh?=
LB1047-RCC MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml7TTWM2OD1yLkC1NFMyKM7:TR?= M2m3ZnNCVkeHUh?=
A253 NGLrcnpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnLYTWM2OD1yLkC1NFUzKM7:TR?= MoLiV2FPT0WU
NCI-H1963 Ml7xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFfOWI9KSzVyPUCuNFUyPzZizszN MWXTRW5ITVJ?
VM-CUB-1 M1vnVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHvtXlhKSzVyPUCuNFU{OTFizszN NEO0elhUSU6JRWK=
T-24 M3XRNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUjJR|UxRTBwMEWzPFQh|ryP M4HwOHNCVkeHUh?=
K-562 Ml\6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWLJR|UxRTBwMEWzPFch|ryP MmrTV2FPT0WU
ARH-77 NEnHTmpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnLzTWM2OD1yLkC1N|k2KM7:TR?= NYO5OlRIW0GQR1XS
CA46 NFPOV5hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4DvRWlEPTB;MD6wOVQ{KM7:TR?= MkjHV2FPT0WU
HCC70 M{Xqdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnexTWM2OD1yLkC1OFUzKM7:TR?= M{\kOnNCVkeHUh?=
ST486 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NU\TO4U5UUN3ME2wMlA2PTJ3IN88US=> NHW5U2tUSU6JRWK=
COLO-741 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXPJR|UxRTBwMEW1N|Eh|ryP MXnTRW5ITVJ?
SK-PN-DW NVPReW93T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV3JR|UxRTBwMEW1PFgh|ryP M1L2bHNCVkeHUh?=
BL-41 NUnSU4FJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{\UTWlEPTB;MD6wOVU6PiEQvF2= MVnTRW5ITVJ?
D-263MG MkHzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUPQfpFIUUN3ME2wMlA2Pjh|IN88US=> NUjt[ZFjW0GQR1XS
KE-37 NEmwNGdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkC1TWM2OD1yLkC1Olg{KM7:TR?= M2DRbXNCVkeHUh?=
LU-134-A MnuyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUHhXYlVUUN3ME2wMlA2PzF3IN88US=> NWLBd3pqW0GQR1XS
HCC2157 NWXPXnVHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUfYVmtJUUN3ME2wMlA2PzN|IN88US=> M2LJR3NCVkeHUh?=
GAK MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFThVmdKSzVyPUCuNFU4OzRizszN Mn;NV2FPT0WU
IST-SL2 NYHkW25oT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHnDRZdKSzVyPUCuNFU4PDNizszN NUTJO45uW0GQR1XS
KMOE-2 NXrRc5dtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1vFdGlEPTB;MD6wOVc1QSEQvF2= Mn7CV2FPT0WU
SW1573 NITzeYtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1Gw[2lEPTB;MD6wOVgxOiEQvF2= NUPWUYgzW0GQR1XS
SCC-9 NUfKO3JGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWTJR|UxRTBwMEW4O{DPxE1? M3PNe3NCVkeHUh?=
MDA-MB-361 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGrkRZhKSzVyPUCuNFU5PzJizszN MV;TRW5ITVJ?
BHT-101 MofIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmC3TWM2OD1yLkC1PFc3KM7:TR?= M1[5R3NCVkeHUh?=
NCI-H1770 MoXaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFf4T4hKSzVyPUCuNFU5PzlizszN NF\0R|ZUSU6JRWK=
UACC-893 M{XKZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3nTd2lEPTB;MD6wOVg6PiEQvF2= NWn2d4Z6W0GQR1XS
NCI-H226 NYHlO45xT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVfJR|UxRTBwMEW5PFgh|ryP NVjTRYFQW0GQR1XS
HLE NHu4T4hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWfRNGZlUUN3ME2wMlA3ODh{IN88US=> NYX4VG46W0GQR1XS
NCI-H1703 NYLrUGxUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3;S[WlEPTB;MD6wOlE4QCEQvF2= M33DV3NCVkeHUh?=
KURAMOCHI NFTEd21Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWTlR4c{UUN3ME2wMlA3OTh7IN88US=> NITGOnBUSU6JRWK=
RH-1 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3;EfmlEPTB;MD6wOlI{KM7:TR?= M1n0bnNCVkeHUh?=
DSH1 NHq2cXlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkPkTWM2OD1yLkC2Nlch|ryP NUnFXJVUW0GQR1XS
CAMA-1 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXHUPW1uUUN3ME2wMlA3OzB|IN88US=> MoDSV2FPT0WU
NCI-H1437 NFPLUFBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlzJTWM2OD1yLkC2N|I5KM7:TR?= NHLyWGVUSU6JRWK=
HuP-T4 NFPxdHBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVnSb4VNUUN3ME2wMlA3PTh4IN88US=> MnTXV2FPT0WU
HCT-15 MlPDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NInud|BKSzVyPUCuNFY2QTdizszN MXLTRW5ITVJ?
NCCIT MkXxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NI\OU5BKSzVyPUCuNFY3ODRizszN MkfaV2FPT0WU
BOKU M3vMVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIP3fIFKSzVyPUCuNFY3PzRizszN MYLTRW5ITVJ?
FADU NEDGRohIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXTSRnZnUUN3ME2wMlA3PzR3IN88US=> M{GzcnNCVkeHUh?=
SUP-T1 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkP4TWM2OD1yLkC2O|Yh|ryP MYPTRW5ITVJ?
L-363 MnvQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHTSS3VKSzVyPUCuNFY6ODFizszN MVvTRW5ITVJ?
KNS-81-FD NFz5OXJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVOwT3NRUUN3ME2wMlA3QTF6IN88US=> NH;TSm9USU6JRWK=
SU-DHL-1 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mne0TWM2OD1yLkC2PVIh|ryP NYDVe441W0GQR1XS
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NCI-H1581 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4TpUGlEPTB;MT6zOVY5PyEQvF2= NWi5[ZZjW0GQR1XS
NCI-H748 M17r[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUjKVWxUUUN3ME2xMlM2PzN6IN88US=> MYPTRW5ITVJ?
HCC1187 NWeyclRLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEjVdoNKSzVyPUGuOVU2OjJizszN NXP3TVlsW0GQR1XS
EoL-1-cell MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUnFPJUxUUN3ME2xMlU5QDh7IN88US=> M1nvVnNCVkeHUh?=
HuO-3N1 NHHhUmZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVvJR|UxRTFwOEO0NVIh|ryP MVTTRW5ITVJ?
NCI-H1793 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWLJR|UxRTFwOEe1PVMh|ryP M4TydHNCVkeHUh?=
Caov-3 Ml32S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFnSW3BKSzVyPUKuNFA3OjVizszN MkTNV2FPT0WU
JAR M4T4V2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlHvTWM2OD1{LkC3PVIh|ryP MoLGV2FPT0WU
SK-MEL-28 Mn;GS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1\qXmlEPTB;Mj6xPFA6QCEQvF2= NGn1XHlUSU6JRWK=
EM-2 NHf0Z5dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4eyOmlEPTB;Mj6yNFI6OyEQvF2= NV7tT29wW0GQR1XS
Mewo NXvDWWFJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoKzTWM2OD1{LkKyNlY2KM7:TR?= MVXTRW5ITVJ?
NCI-H720 NF3Q[ZNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWixdHNFUUN3ME2yMlI3PTh3IN88US=> NEjmbZFUSU6JRWK=
CAL-54 NWr4OWlzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkPITWM2OD1{LkK2O|k2KM7:TR?= MWLTRW5ITVJ?
MC116 M4TSO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4HONGlEPTB;Mj6zOlM6PyEQvF2= NFPUeYRUSU6JRWK=
DG-75 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3zySWlEPTB;Mj60PFU4PiEQvF2= MYrTRW5ITVJ?
HCC1143 NYThPYUxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3OzTWlEPTB;Mj61NFY2QCEQvF2= NYnGWmx4W0GQR1XS
FTC-133 NUPrTI8zT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUjJR|UxRTJwNUO2PFkh|ryP MW\TRW5ITVJ?
AsPC-1 M3TXNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHnYNnVKSzVyPUKuOVM6OjlizszN M1XsR3NCVkeHUh?=
NCI-H889 NF\I[3lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{jle2lEPTB;Mj61OlcxPiEQvF2= Mn23V2FPT0WU
HT55 NXr5UFBuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYLJR|UxRTJwNkKwNVkh|ryP Mn3pV2FPT0WU
UMC-11 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M37ySWlEPTB;Mj63PFcyPSEQvF2= NIXnSXZUSU6JRWK=
P12-ICHIKAWA MnLIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2T0TmlEPTB;Mj64NlA1PiEQvF2= M4P4R3NCVkeHUh?=
HCC1395 MlLpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGHoTJdKSzVyPUKuPVg3ODJizszN NWf2S|Z2W0GQR1XS
D-283MED NHvKO3BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkHUTWM2OD1|LkG4PVM4KM7:TR?= NVTXWYxEW0GQR1XS
COLO-800 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVPoe2RHUUN3ME2zMlM{QDl5IN88US=> M4Tud3NCVkeHUh?=
MFM-223 MlHtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUTHepZCUUN3ME2zMlM3ODl5IN88US=> NWPkWYhJW0GQR1XS
TE-5 M16zemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUPJR|UxRTRwNU[xOFch|ryP MUjTRW5ITVJ?
NCI-H209 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3nH[GlEPTB;ND63PFU4OiEQvF2= MWXTRW5ITVJ?
SiHa M2PIZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYmwSXZZUUN3ME20Mlk2OjB|IN88US=> Moe4V2FPT0WU
NCI-H1395 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWjJR|UxRTVwMUC2N|Mh|ryP MXvTRW5ITVJ?
A498 NWnvfJJrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MonCTWM2OD13LkKxNlUyKM7:TR?= MnPnV2FPT0WU
ES5 NI[5VpRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEj0[YVKSzVyPUWuOlEyPzhizszN NITnUmpUSU6JRWK=
MDA-MB-157 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXTJR|UxRTVwNk[0OFMh|ryP MXTTRW5ITVJ?
NCI-H1623 M4jYWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnOyTWM2OD13LkizOVU3KM7:TR?= M2K0e3NCVkeHUh?=
RPMI-8866 M1;LdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH7KTYVKSzVyPUWuPFQ4QTJizszN MmrRV2FPT0WU
LC-1F NUL5N45vT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUnw[W4xUUN3ME22MlA6OjlzIN88US=> M3HaenNCVkeHUh?=
TCCSUP NHjMcJVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmHxTWM2OD14Lk[wN|Q6KM7:TR?= NWDQN|VVW0GQR1XS
TT NF;vPZFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVTTenR7UUN3ME24MlM{ODB7IN88US=> MVnTRW5ITVJ?
NCI-H1838 M2LlNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M13jcmlEPTB;OD61NVc{OSEQvF2= M1nDT3NCVkeHUh?=
NCI-H322M M2TmXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1;3d2lEPTB;OT6xOlI5OSEQvF2= NFrrXXNUSU6JRWK=
NCI-H187 M4jDOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUiwUHR4UUN3ME25MlUyQDN3IN88US=> MkflV2FPT0WU
SBC-1 NILaSplIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFXoZZlKSzVyPUmuPVM3PTZizszN MmfoV2FPT0WU
SCC-3 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4fkU2lEPTB;MUCuOVY4QSEQvF2= MU\TRW5ITVJ?
SW948 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NW\tVoRxUUN3ME2xNE44PTFzIN88US=> NWeyXG1bW0GQR1XS
CPC-N NIj4[IpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmPPTWM2OD1zMT6wNFch|ryP MlW1V2FPT0WU
TGBC24TKB NFfXU|RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIPLZoxKSzVyPUGzMlUzQSEQvF2= MXLTRW5ITVJ?
NCI-H2452 M1XnZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{nK[2lEPTB;MUSuO|Mh|ryP MWDTRW5ITVJ?
Hs-578-T MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGO0XGJKSzVyPUG4MlU4PTlizszN NHH1[oJUSU6JRWK=
DV-90 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWqzSW8xUUN3ME2xPE46QTR3IN88US=> M1js[3NCVkeHUh?=
NCI-H1563 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{fnTmlEPTB;MUmuO|g5QCEQvF2= NVvhUnZDW0GQR1XS
SW780 MkXzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml7ZTWM2OD1{MT6xN|E5KM7:TR?= MYfTRW5ITVJ?
NCI-H345 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXzJR|UxRTJzLki3O|kh|ryP Ml30V2FPT0WU
LB771-HNC M4noU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnLVTWM2OD1{Mj60PFE{KM7:TR?= MXXTRW5ITVJ?
RT4 NYjidXlTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF;VT4tKSzVyPUKzMlMzQDJizszN NYLWZ|hrW0GQR1XS
NCI-H82 NIrGWJJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXvJR|UxRTJ|LkW1NlYh|ryP NETQfmdUSU6JRWK=
NCI-H524 M4ewemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVfJR|UxRTJ2LkO4NVIh|ryP MkLIV2FPT0WU
SNU-C1 M2rKSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWfzTHNxUUN3ME2yOE46OTB3IN88US=> NHvZWIhUSU6JRWK=
NCI-SNU-16 MoLiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVnJR|UxRTR6LkOxOFIh|ryP MkHBV2FPT0WU

... Click to View More Cell Line Experimental Data

In vivo Treatment with NVP-AUY922 causes a robust antitumor response and inhibits p-Akt and VEGF expression in an HSC-2 xenograft model. [2] In BT474, NVP-AUY922 shows complete loss of ERBB2 and substantial depletion of ERα, in addition to reductions in CDK4 and phospho-ERK1/2. [3]

Protocol

Kinase Assay:[3]
+ Expand

Kinase assay:

NVP-AUY922 is dissolved in DMSO at a concentration of 10 mM. NVP-AUY922 is assessed against HSP90α, HSP90β, GRP94, TRAP-1, HSP72, and topoisomerase II. Profiling against a panel of kinases has been carried out and screening against a panel of additional enzymes and receptors is performed at Cerep.
Cell Research:[1]
+ Expand
  • Cell lines: Human gastric cancer cells NCI-N87
  • Concentrations: 1 μM
  • Incubation Time: 3 days
  • Method: Human gastric cancer cells NCI-N87 (5-7 ×103 in 50 μL/well) are seeded in 96-well plates and incubated at 37 °C for 24 hours, followed by NVP-AUY922 treatment for 1-3 days at 37 °C. After treatment, the cells are assayed by MTT method and analyzed by microplate reader.
    (Only for Reference)
Animal Research:[3]
+ Expand
  • Animal Models: Female NCr athymic mice bearing WM266.4 human melanoma xenografts
  • Formulation: In DMSO and diluted in sterile saline/Tween 20
  • Dosages: 50 mg/kg
  • Administration: Administered via i.v. or i.p.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 93 mg/mL warmed (199.76 mM)
Ethanol 31 mg/mL (66.58 mM)
Water Insoluble
In vivo Add solvents to the product individually and in order:
1% DMSO+30% polyethylene glycol+1% Tween 80
For best results, use promptly after mixing.
30 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 465.54
Formula

C26H31N3O5

CAS No. 747412-49-3
Storage powder
Synonyms VER-52296

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

  • Mass
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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
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    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
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    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT01784640 Active, not recruiting Recurrent Non-small Cell Lung Cancer|Squamous Cell Lung Cancer|Stage IV Non-small Cell Lung Cancer Jonsson Comprehensive Cancer Center|National Cancer Institute (NCI) January 2014 Phase 1
NCT01922583 Active, not recruiting Non-small Cell Lung Cancer (NSCLC) National Taiwan University Hospital January 2014 Phase 2
NCT01854034 Active, not recruiting Non Small Cell Lung Cancer Massachusetts General Hospital July 2013 Phase 2
NCT01772797 Completed Anaplastic Lymphoma Kinase (ALK)|Non-small Cell Lung Cancer Novartis Pharmaceuticals|Novartis June 2013 Phase 1
NCT01752400 Active, not recruiting Non Small Cell Lung Cancer Massachusetts General Hospital January 2013 Phase 2
NCT01613950 Completed Stomach Neoplasms Esophageal Neoplasms Metastatic Gastric Cancer Mutated PI3KCA Protein Overexpressed HER2 Protein Novartis Pharmaceuticals|Novartis December 2012 Phase 1

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

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HSP (e.g. HSP90) Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID