Luminespib (AUY-922, NVP-AUY922)

Catalog No.S1069 Synonyms: VER-52296

Luminespib (AUY-922, NVP-AUY922) Chemical Structure

Molecular Weight(MW): 465.54

Luminespib (AUY-922, NVP-AUY922) is a highly potent HSP90 inhibitor for HSP90α/β with IC50 of 13 nM /21 nM in cell-free assays, weaker potency against the HSP90 family members GRP94 and TRAP-1, exhibits the tightest binding of any small-molecule HSP90 ligand. Phase 2.

Size Price Stock Quantity  
In DMSO USD 320 In stock
USD 160 In stock
USD 270 In stock
USD 470 In stock

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3 Customer Reviews

  • U2OS_exo cells were incubated with AUY922 for 20 h at the indicated concentrations before stimulation with TNFα (30 ng/mL) for 30 min and immunostaining to detect NF-κB (p65). DMSO 1%, cells stimulated by TNFα in the absence of AUY922. Representative pictures used to quantify nuclear and cytoplasmic localization of NF-κB.

    Proc Natl Acad Sci USA, 2014, 111(15): E1528–37 . Luminespib (AUY-922, NVP-AUY922) purchased from Selleck.

    J Biol Chem 2013 288(23), 16308-20. Luminespib (AUY-922, NVP-AUY922) purchased from Selleck.

  • Western blots show the molecular signature of HSP90 inhibition by NVP-AUY922  (ie, induction of HSP72 and depletion of client proteins such as ERBB2, CRAF and CDK4) in BT474 breast cancer cell line. GAPDH was used as loading control.

     

     

    2011 Dr. Swee Sharp and Professor Paul Workman from Cancer Research UK. Luminespib (AUY-922, NVP-AUY922) purchased from Selleck.

Purity & Quality Control

Choose Selective HSP (e.g. HSP90) Inhibitors

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Notes:

2. For more details, such as half maximal inhibitory concentrations (IC50s) and working concentrations of each inhibitor, please click on the link of the inhibitor of interest.
3. "+" indicates inhibitory effect. Increased inhibition is marked by a higher "+" designation.
4. Orange "√" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

Biological Activity

Description Luminespib (AUY-922, NVP-AUY922) is a highly potent HSP90 inhibitor for HSP90α/β with IC50 of 13 nM /21 nM in cell-free assays, weaker potency against the HSP90 family members GRP94 and TRAP-1, exhibits the tightest binding of any small-molecule HSP90 ligand. Phase 2.
Targets
HSP90α [1]
(Cell-free assay)
HSP90β [1]
(Cell-free assay)
13 nM 21 nM
In vitro

NVP-AUY922 inhibits proliferation of various human cancer cell lines in vitro, with an average GI50 of 9 nM. [1] The IC50 values of NVP-AUY922 fall in the range of 2 to 40 nM in these gastric cancer cell lines. IC50 value for the BEAS-2B cells is 28.49 nM. Treatment with NVP-AUY922 does not influence the expression of HSP90, but expression of HSP70 gets elevated by NVP-AUY922 treatment. NVP-AUY922 increases the binding of HSP70 to HSP90. NVP-AUY922 causes p23 dissociation from the HSP90 complex and can then recruit HSP70 to the HSP90 complex. [1] After the treatment with NVP-AUY922, expression of receptor tyrosine kinases including VEGFR1, 2, 3 and PDGFRɑ is decreased. A decrease is also noticed in the expression of Akt and phospho-Akt. Meanwhile, treatment with NVP-AUY922 causes decreased expression of HER-2 in NCI-N87 cells. NVP-AUY922 treatment results in binding of HSP90 to client proteins and setting them up as targets for degradation by the proteasome. NVP-AUY922 can influence cell growth by affecting multiple signaling pathways. In addition, treatment with the proteasome inhibitor, MG132, restores expression of thymidylate synthase, which is decreased by NVP-AUY922. NVP-AUY922 increases the expression of cleaved caspase-3 leading to apoptosis in HSC-2 cells.[1]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
CMK NFnPOVNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NG\MNJdKSzVyPUCuNFAxOTJ3IN88US=> NYXHNYZGW0GQR1XS
MV-4-11 M1Wxc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml\jTWM2OD1yLkCwNFU2QCEQvF2= NH;INHZUSU6JRWK=
NALM-6 M{TleWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkP1TWM2OD1yLkCwNFg1OiEQvF2= MWfTRW5ITVJ?
HOS MljaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVXJR|UxRTBwMECxN|gh|ryP NIK2Z5RUSU6JRWK=
HT-144 M4LMcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUe4TohZUUN3ME2wMlAxOTV3IN88US=> MmDZV2FPT0WU
SW1710 NVTyUWJYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVHJR|UxRTBwMECxPFYh|ryP MUTTRW5ITVJ?
TE-8 NITmUmRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlnPTWM2OD1yLkCwNlM4KM7:TR?= NX;vSWdVW0GQR1XS
ES1 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmPITWM2OD1yLkCwNlY3KM7:TR?= M1;HcXNCVkeHUh?=
CCF-STTG1 NEnRPHdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH7ON29KSzVyPUCuNFAzQTdizszN MYfTRW5ITVJ?
PSN1 M4T6OGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NETTcI5KSzVyPUCuNFA{OThizszN NFjFW|ZUSU6JRWK=
CAL-51 NIHTSWtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHKwOm9KSzVyPUCuNFA{OjVizszN NXnSdFZ4W0GQR1XS
MCF7 M17hZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlvBTWM2OD1yLkCwN|M2KM7:TR?= MoTzV2FPT0WU
SK-HEP-1 NGTGc2NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2r6O2lEPTB;MD6wNFM{PiEQvF2= MmHiV2FPT0WU
LCLC-103H NGHhVHdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3jDdWlEPTB;MD6wNFQ{KM7:TR?= MkHNV2FPT0WU
HMV-II NGnvTHdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV;JR|UxRTBwMEC0OFkh|ryP MVPTRW5ITVJ?
MES-SA NHnaZ|NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHrZNJZKSzVyPUCuNFA1PTJizszN M2n2SHNCVkeHUh?=
SK-LMS-1 NWryRnB2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkTpTWM2OD1yLkCwOFU5KM7:TR?= MYLTRW5ITVJ?
639-V MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1rCemlEPTB;MD6wNFQ5PSEQvF2= NETKcHlUSU6JRWK=
SIG-M5 NX;URXpqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIrRSmtKSzVyPUCuNFA1QDlizszN MXjTRW5ITVJ?
LOUCY M2TrfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoHTTWM2OD1yLkCwOVA2KM7:TR?= M13VV3NCVkeHUh?=
HSC-2 NXfOOHhbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1Xt[2lEPTB;MD6wNFUyQCEQvF2= M2rZNHNCVkeHUh?=
EW-13 M1PwfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1P3OWlEPTB;MD6wNFUyQCEQvF2= NHrtNHpUSU6JRWK=
RT-112 M3rPZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{TrVmlEPTB;MD6wNFU{PSEQvF2= MWTTRW5ITVJ?
NKM-1 M2mybmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXPJR|UxRTBwMEC1OFch|ryP NVnF[os2W0GQR1XS
KYSE-180 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUjoXWg5UUN3ME2wMlAxPTh4IN88US=> NYqz[mtrW0GQR1XS
SW1783 M3v2dGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH3HRlVKSzVyPUCuNFA2QTFizszN NEC5cFBUSU6JRWK=
A431 MnHTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVLuNVN1UUN3ME2wMlAxPjB5IN88US=> MkP1V2FPT0WU
SK-OV-3 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmLSTWM2OD1yLkCwOlMh|ryP M2f5VHNCVkeHUh?=
RPMI-7951 MnnoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXjJR|UxRTBwMEC2N|Eh|ryP MoHsV2FPT0WU
Capan-2 MoTsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkHDTWM2OD1yLkCwOlM5KM7:TR?= Mo\DV2FPT0WU
HSC-3 Mn62S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXq5e2dTUUN3ME2wMlAxPjRzIN88US=> M{HXdnNCVkeHUh?=
786-0 M1nIS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1jqOGlEPTB;MD6wNFY3OyEQvF2= Mn\tV2FPT0WU
Daoy NF\COlRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVjJR|UxRTBwMEC2PVUh|ryP M1z0cHNCVkeHUh?=
KGN NYHuXmRyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWDJR|UxRTBwMEC3NFMh|ryP Mnr3V2FPT0WU
EW-16 M2CyPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVjJR|UxRTBwMEC3OFkh|ryP NFvyeYVUSU6JRWK=
EW-7 MoC2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH\Qc2hKSzVyPUCuNFA4PTRizszN M162bHNCVkeHUh?=
IGROV-1 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mm\vTWM2OD1yLkCwPFE1KM7:TR?= NXPq[3F4W0GQR1XS
8505C NYfCZZJrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUKye3JMUUN3ME2wMlAxQDJzIN88US=> NWW0XJhUW0GQR1XS
RKO M2O3Z2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHezbHNKSzVyPUCuNFA5OjZizszN NH3CbXpUSU6JRWK=
GDM-1 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mk\YTWM2OD1yLkCwPFQh|ryP NFL2eIdUSU6JRWK=
IST-MEL1 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkC1TWM2OD1yLkCwPFUzKM7:TR?= MmHvV2FPT0WU
RPMI-6666 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUXuT4lDUUN3ME2wMlAxQDV{IN88US=> NIrRTm9USU6JRWK=
SNG-M NGjyR3BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVTJR|UxRTBwMEC4OVYh|ryP NImzcphUSU6JRWK=
KS-1 NVPlT2hbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWrJR|UxRTBwMEC4OVkh|ryP NYDWXnVmW0GQR1XS
RXF393 M4LlT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2\TeGlEPTB;MD6wNFg3KM7:TR?= M1G0UHNCVkeHUh?=
CAL-12T NYq5TlZHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3;ydGlEPTB;MD6wNFkzOiEQvF2= NH\ES5VUSU6JRWK=
BFTC-905 M3i5Zmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmTUTWM2OD1yLkCwPVM5KM7:TR?= MV;TRW5ITVJ?
SK-MES-1 M4TlUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXXidpBVUUN3ME2wMlAxQTR3IN88US=> NGLFTYVUSU6JRWK=
BB30-HNC MoK4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2rEUGlEPTB;MD6wNFk2OiEQvF2= MkDXV2FPT0WU
AN3-CA MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGLyb|lKSzVyPUCuNFExOTdizszN NUHDOHpzW0GQR1XS
EFO-27 M4\Tc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVfE[VkyUUN3ME2wMlAyODF5IN88US=> NID3dItUSU6JRWK=
G-401 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3HSN2lEPTB;MD6wNVAzPSEQvF2= NU\mbZdtW0GQR1XS
BPH-1 NHS2S3BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnznTWM2OD1yLkCxNFMh|ryP MXnTRW5ITVJ?
NCI-H727 NWrGcIRtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUfJR|UxRTBwMEGwN{DPxE1? M2PBcnNCVkeHUh?=
SNU-423 M4X3c2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVrJR|UxRTBwMEGwOVMh|ryP NHTzdZJUSU6JRWK=
KYSE-270 NWPsdnBmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NU\XNpdMUUN3ME2wMlAyODV7IN88US=> NUH3N2FCW0GQR1XS
AGS NHXWcodIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUDJR|UxRTBwMEGwOlEh|ryP NYC1U4JiW0GQR1XS
NCI-H2228 NUT2SJI6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M37FcmlEPTB;MD6wNVA3PCEQvF2= NUjCe49QW0GQR1XS
SW954 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2H2bWlEPTB;MD6wNVA4OSEQvF2= M3jRe3NCVkeHUh?=
769-P NUnJfIlET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGrue2xKSzVyPUCuNFExPzNizszN M2TORXNCVkeHUh?=
BB49-HNC MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{\mdGlEPTB;MD6wNVA4PyEQvF2= MlG0V2FPT0WU
IA-LM NWiycGNVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWXFd|NQUUN3ME2wMlAyODh4IN88US=> MU\TRW5ITVJ?
NB69 NVrkNlBbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXvFeXJTUUN3ME2wMlAyOTB{IN88US=> MofuV2FPT0WU
C8166 M3[xWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX\JR|UxRTBwMEGxNlkh|ryP NYXFbZRQW0GQR1XS
NCI-H1299 M1jCOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NW\3[lJJUUN3ME2wMlAyOTV2IN88US=> NWjCfmtlW0GQR1XS
YKG-1 NHyz[oFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXzQflk{UUN3ME2wMlAyOTZizszN M3\zfnNCVkeHUh?=
PANC-03-27 M2TxSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIfF[FdKSzVyPUCuNFEyPjJizszN NHvZOHlUSU6JRWK=
YT NVTtd5h1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1rVPWlEPTB;MD6wNVE4QSEQvF2= NIC3RZhUSU6JRWK=
CAL-85-1 NUXRVXN7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVXJR|UxRTBwMEGxPVIh|ryP MYjTRW5ITVJ?
GT3TKB MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX7JR|UxRTBwMEGyNFIh|ryP MX7TRW5ITVJ?
BB65-RCC MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVuxcJg{UUN3ME2wMlAyOjB2IN88US=> MWPTRW5ITVJ?
ES6 M4fp[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4rHVWlEPTB;MD6wNVI3OSEQvF2= M1zpZ3NCVkeHUh?=
MHH-ES-1 M4mzSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYrJR|UxRTBwMEGyOlMh|ryP M3e2d3NCVkeHUh?=
QIMR-WIL MnnNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWrJR|UxRTBwMEGyOlkh|ryP MmT2V2FPT0WU
SNU-C2B MkHVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWTi[3dCUUN3ME2wMlAyOjd{IN88US=> NWTjWFYzW0GQR1XS
OCI-AML2 NVW1RXkyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWjpO2dtUUN3ME2wMlAyOjhzIN88US=> MYPTRW5ITVJ?
DU-145 NHzON3BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3PMdmlEPTB;MD6wNVI6KM7:TR?= NEnYUmJUSU6JRWK=
SW982 NF31cGhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlLWTWM2OD1yLkCxNlk{KM7:TR?= MkW0V2FPT0WU
MFH-ino NFixfZlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFz5bGZKSzVyPUCuNFEzQTNizszN NF3mU4lUSU6JRWK=
A427 MlXzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{DqcGlEPTB;MD6wNVI6QSEQvF2= MoC4V2FPT0WU
LCLC-97TM1 Ml;4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVXJR|UxRTBwMEGzJO69VQ>? M1jWbXNCVkeHUh?=
AM-38 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkTqTWM2OD1yLkCxN|AzKM7:TR?= MmP5V2FPT0WU
K5 NH:1T3pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1HydmlEPTB;MD6wNVMxQCEQvF2= MW\TRW5ITVJ?
T84 NUfJOZZIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYjjTmtuUUN3ME2wMlAyOzNzIN88US=> M{G3cnNCVkeHUh?=
TE-15 M4jsXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3jJZWlEPTB;MD6wNVM{PiEQvF2= NXm2XHV1W0GQR1XS
NCI-H460 NXvaSnV2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYrJR|UxRTBwMEGzN|Yh|ryP Moe0V2FPT0WU
NTERA-S-cl-D1 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUnJR|UxRTBwMEGzN|kh|ryP MmX3V2FPT0WU
KYSE-450 MkH1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2n3N2lEPTB;MD6wNVM1QSEQvF2= M1i3Z3NCVkeHUh?=
H4 M2HadWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEWzWFZKSzVyPUCuNFE{PjZizszN MlTNV2FPT0WU
LC-2-ad MkX3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF\WN21KSzVyPUCuNFE{PyEQvF2= MUHTRW5ITVJ?
GAMG M1jZR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoTSTWM2OD1yLkCxN|cyKM7:TR?= MVTTRW5ITVJ?
TK10 NVPFU5BmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUTxRXJDUUN3ME2wMlAyOzh{IN88US=> MYTTRW5ITVJ?
NCI-H2122 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1zkUWlEPTB;MD6wNVM5PCEQvF2= MoXrV2FPT0WU
KM12 NU[2NHdST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmjYTWM2OD1yLkCxN|k6KM7:TR?= NF3ibmhUSU6JRWK=
CAL-39 M{LoPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkP4TWM2OD1yLkCxOFIh|ryP MX7TRW5ITVJ?
RPMI-2650 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFL1OI1KSzVyPUCuNFE1OzJizszN MoDaV2FPT0WU
KYSE-510 NVTwOVdIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHn6eFlKSzVyPUCuNFE1PDJizszN MW\TRW5ITVJ?
KALS-1 NVvhWHNsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWfRWIpoUUN3ME2wMlAyPDZ4IN88US=> NFXuPZBUSU6JRWK=
NCI-H1648 NWnHUXQyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHvXOVJKSzVyPUCuNFE1QTlizszN NVHYU5J6W0GQR1XS
ES4 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHflR|VKSzVyPUCuNFE2ODJizszN MljHV2FPT0WU
C-33-A M3v2[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3PLV2lEPTB;MD6wNVUxQSEQvF2= M1LLcHNCVkeHUh?=
MIA-PaCa-2 M2rkWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWfJR|UxRTBwMEG1NFkh|ryP MlG0V2FPT0WU
Becker NFO0ZmNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUTJR|UxRTBwMEG1NVQh|ryP M332NHNCVkeHUh?=
HOP-62 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnrQTWM2OD1yLkCxOVQzKM7:TR?= NXTFTXJDW0GQR1XS
TE-1 NHvhdVBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYLvWINoUUN3ME2wMlAyPThzIN88US=> M3i1VnNCVkeHUh?=
KYSE-410 NUHTbJBDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWm4fmRnUUN3ME2wMlAyPTh4IN88US=> NWjWPXVwW0GQR1XS
NOS-1 MmLsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{TFcGlEPTB;MD6wNVU6OyEQvF2= NXf2NWV4W0GQR1XS
MEL-HO M1TiNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUTJR|UxRTBwMEG2OFMh|ryP MV3TRW5ITVJ?
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Daudi MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIfucoxKSzVyPUCuNFM{PzZizszN NFrrPYdUSU6JRWK=
RS4-11 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFTiXHlKSzVyPUCuNFM{QDNizszN NEGwd|dUSU6JRWK=
JiyoyeP-2003 MmfRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFjPW41KSzVyPUCuNFM{QDhizszN NUPIWIx4W0GQR1XS
BL-70 MlPvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{\vdGlEPTB;MD6wN|M5QSEQvF2= MWHTRW5ITVJ?
OS-RC-2 NUPKWHdQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX3YXVU3UUN3ME2wMlA{Ozl4IN88US=> MW\TRW5ITVJ?
SF268 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnzSTWM2OD1yLkCzOFAyKM7:TR?= NE\J[llUSU6JRWK=
BV-173 NGD1Zm5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3fPPWlEPTB;MD6wN|QzPiEQvF2= M1jPSnNCVkeHUh?=
DMS-273 MkCyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYXLbnBJUUN3ME2wMlA{PDd7IN88US=> MVrTRW5ITVJ?
22RV1 M2XUUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1HtbmlEPTB;MD6wN|UxPyEQvF2= NVTtdZpvW0GQR1XS
ES8 M3HvSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mke2TWM2OD1yLkCzOVM5KM7:TR?= Ml\hV2FPT0WU
KYSE-150 NUXwOYRvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnO3TWM2OD1yLkCzOlA5KM7:TR?= MlTyV2FPT0WU
HCC1569 MmDvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVLITlY3UUN3ME2wMlA{PjB6IN88US=> MWTTRW5ITVJ?
NB5 MnPUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3fyNGlEPTB;MD6wN|YyOyEQvF2= NF:4S2hUSU6JRWK=
G-402 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M165XWlEPTB;MD6wN|YyPCEQvF2= MVjTRW5ITVJ?
NCI-H1693 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV7JR|UxRTBwMEO2NVch|ryP MoS4V2FPT0WU
LB2241-RCC MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX\ueZNnUUN3ME2wMlA{PjR{IN88US=> NWXyW251W0GQR1XS
KP-4 NEDoWGdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{PDW2lEPTB;MD6wN|Y3OyEQvF2= MY\TRW5ITVJ?
ML-2 M{e4Vmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEjESpRKSzVyPUCuNFM3PzFizszN MYXTRW5ITVJ?
KU812 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEjuVpZKSzVyPUCuNFM3QDRizszN NE[yZ5FUSU6JRWK=
LS-411N MmqzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NY[ySnVQUUN3ME2wMlA{PzNzIN88US=> M{\4cHNCVkeHUh?=
OAW-42 NGTOO4VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1HYTGlEPTB;MD6wN|c1PyEQvF2= M1v5c3NCVkeHUh?=
HCC38 NUTESHdoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUizR3NqUUN3ME2wMlA{PzdzIN88US=> NIHldZRUSU6JRWK=
Ca-Ski NWLmSFVUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF\LSXhKSzVyPUCuNFM4QDRizszN Mlr3V2FPT0WU
Calu-3 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVLme485UUN3ME2wMlA{Pzh7IN88US=> NUfwUnFEW0GQR1XS
KYSE-70 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVn5WWY{UUN3ME2wMlA{QDF{IN88US=> M1m2[XNCVkeHUh?=
D-392MG NHLINIxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFHp[JBKSzVyPUCuNFM5PDJizszN NV;kUJVwW0GQR1XS
OVCAR-4 NVfVc2F6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{LxemlEPTB;MD6wN|g2QCEQvF2= NHW0UWZUSU6JRWK=
Detroit562 MlK0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF;qOJFKSzVyPUCuNFM5PzJizszN NIS2eoxUSU6JRWK=
HEL NX7hbnBUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYjJR|UxRTBwMEO4PVEh|ryP M3fTc3NCVkeHUh?=
MONO-MAC-6 NWL0VlY3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1jKS2lEPTB;MD6wN|g6OyEQvF2= MYDTRW5ITVJ?
LoVo M4\LR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmnMTWM2OD1yLkCzPVM{KM7:TR?= M{T2WHNCVkeHUh?=
U-2-OS MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoHFTWM2OD1yLkCzPVM2KM7:TR?= NFLC[3VUSU6JRWK=
A172 NXvIenFMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4mwVmlEPTB;MD6wN|k2KM7:TR?= NYj5eIZ2W0GQR1XS
OCUB-M NVnyblZuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXfJR|UxRTBwMEO5OlEh|ryP NYjs[VI5W0GQR1XS
SW48 NHfrN2ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mmq0TWM2OD1yLkC0NFMyKM7:TR?= M{DyZnNCVkeHUh?=
HC-1 MkC0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWjx[WZXUUN3ME2wMlA1ODZ7IN88US=> MnnWV2FPT0WU
KOSC-2 NV65flRnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUDJOYYzUUN3ME2wMlA1OTFizszN MlzjV2FPT0WU
HDLM-2 NUfQNGFCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYLGWWw{UUN3ME2wMlA1OTF2IN88US=> M1O0ZnNCVkeHUh?=
CTV-1 NXz3eZhXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF33R5VKSzVyPUCuNFQyOTZizszN NYThPZFXW0GQR1XS
SH-4 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF\WdY5KSzVyPUCuNFQyPDFizszN NV:5Nml5W0GQR1XS
SW756 M1vBb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYPJR|UxRTBwMESxOVch|ryP NHjSTYdUSU6JRWK=
GCT NGPaTZBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlrITWM2OD1yLkC0NVYyKM7:TR?= NE\FZnVUSU6JRWK=
CHL-1 NHLyTYlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVTJR|UxRTBwMESxOlkh|ryP MoC0V2FPT0WU
LAMA-84 NVfFWYlTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2jpcmlEPTB;MD6wOFE4OSEQvF2= M3TGdHNCVkeHUh?=
LS-1034 MmXIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXjJR|UxRTBwMESxPVEh|ryP NILwW3pUSU6JRWK=
NCI-H358 M{\XWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlrtTWM2OD1yLkC0NlEzKM7:TR?= MlrQV2FPT0WU
NB13 M3\IcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlnsTWM2OD1yLkC0NlI4KM7:TR?= MVLTRW5ITVJ?
TE-9 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmHtTWM2OD1yLkC0NlM4KM7:TR?= NHjyWHJUSU6JRWK=
OE33 NF\Cc21Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHPlN3VKSzVyPUCuNFQzPDFizszN MWfTRW5ITVJ?
CAL-120 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkjsTWM2OD1yLkC0NlQyKM7:TR?= MYPTRW5ITVJ?
DJM-1 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXfn[GpyUUN3ME2wMlA1Ojd{IN88US=> M3zEO3NCVkeHUh?=
SK-MEL-24 Mn;ES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWi0PJZmUUN3ME2wMlA1Ojh|IN88US=> NVTKOGJEW0GQR1XS
VA-ES-BJ NF;veFlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHv5OnpKSzVyPUCuNFQzQTJizszN M1rKfnNCVkeHUh?=
MMAC-SF MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml7QTWM2OD1yLkC0Nlk4KM7:TR?= NYPyTVJVW0GQR1XS
MZ7-mel NXW0UXRoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlPnTWM2OD1yLkC0N|Mh|ryP NX32VYNoW0GQR1XS
BxPC-3 M4PJeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3ywbmlEPTB;MD6wOFM1OSEQvF2= MV7TRW5ITVJ?
HT-29 NFjmU5pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M33YXWlEPTB;MD6wOFM2PyEQvF2= MX3TRW5ITVJ?
SK-MEL-30 MmLZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHTK[VRKSzVyPUCuNFQ{PjJizszN NHLCVmtUSU6JRWK=
CAL-33 M{DuWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF[3d|FKSzVyPUCuNFQ{PzVizszN MVfTRW5ITVJ?
COLO-680N MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUTJR|UxRTBwMES0NFch|ryP NXu2OoQ5W0GQR1XS
NH-12 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2\4eWlEPTB;MD6wOFQ1KM7:TR?= MoLLV2FPT0WU
HCC1937 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXLJR|UxRTBwMES0OVYh|ryP NYjMbm1YW0GQR1XS
IMR-5 NGrPNlZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NILFNmZKSzVyPUCuNFQ1QSEQvF2= M3LuWnNCVkeHUh?=
MC-CAR MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVW2O2pCUUN3ME2wMlA1PTZ7IN88US=> M2P1d3NCVkeHUh?=
NCI-H747 M2LPN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{\ZeGlEPTB;MD6wOFU4KM7:TR?= MkHWV2FPT0WU
NCI-H1792 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYPJR|UxRTBwMES1PFEh|ryP M{j6[3NCVkeHUh?=
SW13 NYLONYZ2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4[zN2lEPTB;MD6wOFU6KM7:TR?= M4L4[XNCVkeHUh?=
MLMA NE\Y[XhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{KxPWlEPTB;MD6wOFYxQSEQvF2= NUPvTI9MW0GQR1XS
U251 NEnWdY9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXLJR|UxRTBwMES3OlMh|ryP NHrLc5pUSU6JRWK=
U031 MknoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXPyR4xFUUN3ME2wMlA1PzdzIN88US=> NEHiPYNUSU6JRWK=
ME-180 MljvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{HtTWlEPTB;MD6wOFc5OiEQvF2= NUHyS4hqW0GQR1XS
SK-MEL-3 NHrJbYRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3H1WWlEPTB;MD6wOFgxOiEQvF2= Mn6zV2FPT0WU
MOLT-4 MmPjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVvJR|UxRTBwMES4NFMh|ryP MV3TRW5ITVJ?
PF-382 NHTM[VdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3vUbmlEPTB;MD6wOFgzPiEQvF2= MnLxV2FPT0WU
NUGC-3 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NInpO5ZKSzVyPUCuNFQ5OjdizszN NVjLRVFHW0GQR1XS
NCI-H1417 M4jQWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFjZb2tKSzVyPUCuNFQ5QSEQvF2= M3vaS3NCVkeHUh?=
COLO-205 NY[2XHFuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVfJR|UxRTBwMES5NVkh|ryP NVfV[Y5NW0GQR1XS
TE-441-T MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXPJR|UxRTBwMES5N{DPxE1? NHX3T4xUSU6JRWK=
MKN1 NX7JOHVpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUj2TGlHUUN3ME2wMlA1QTNizszN NXvYenozW0GQR1XS
UM-UC-3 NFq5T|FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3H0dWlEPTB;MD6wOFk2KM7:TR?= NFTs[GhUSU6JRWK=
SF126 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX2xOlBXUUN3ME2wMlA2ODFizszN NHHDeVlUSU6JRWK=
LB1047-RCC NHS3VmtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHL5PXpKSzVyPUCuNFUxOzFizszN MmDjV2FPT0WU
A253 NGD5eGpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYX5RY1VUUN3ME2wMlA2ODV{IN88US=> NU\ndFUyW0GQR1XS
NCI-H1963 NYfSdoo2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF\s[oJKSzVyPUCuNFUyPzZizszN NV\FNoFNW0GQR1XS
VM-CUB-1 M1Pab2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWrJR|UxRTBwMEWzNVEh|ryP NGLYOpdUSU6JRWK=
T-24 MlXMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnWxTWM2OD1yLkC1N|g1KM7:TR?= MXPTRW5ITVJ?
K-562 MnzBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYXJR|UxRTBwMEWzPFch|ryP M13a[HNCVkeHUh?=
ARH-77 NXzJN|JFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUjJR|UxRTBwMEWzPVUh|ryP MULTRW5ITVJ?
CA46 NIWyZ41Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2juemlEPTB;MD6wOVQ{KM7:TR?= NHnqb3BUSU6JRWK=
HCC70 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHvBTY5KSzVyPUCuNFU1PTJizszN NHz4OZZUSU6JRWK=
ST486 MlzES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGPHU3ZKSzVyPUCuNFU2OjVizszN NX;u[YZCW0GQR1XS
COLO-741 NHLRO3hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV3JR|UxRTBwMEW1N|Eh|ryP NE[xTFhUSU6JRWK=
SK-PN-DW MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MW\JR|UxRTBwMEW1PFgh|ryP Mmn4V2FPT0WU
BL-41 NV;6NXhLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXfJR|UxRTBwMEW1PVYh|ryP MmPoV2FPT0WU
D-263MG NWT2PYRMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MULJR|UxRTBwMEW2PFMh|ryP M4[4[XNCVkeHUh?=
KE-37 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1TZbWlEPTB;MD6wOVY5OyEQvF2= Mk\YV2FPT0WU
LU-134-A NUTpepdQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXr3dFBFUUN3ME2wMlA2PzF3IN88US=> MVXTRW5ITVJ?
HCC2157 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1nDcmlEPTB;MD6wOVc{OyEQvF2= MUHTRW5ITVJ?
GAK NWD0c2huT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mm\4TWM2OD1yLkC1O|M1KM7:TR?= MUHTRW5ITVJ?
IST-SL2 NHjmVYdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmTNTWM2OD1yLkC1O|Q{KM7:TR?= NVXSenczW0GQR1XS
KMOE-2 NYq2VlFCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NG\TO|hKSzVyPUCuNFU4PDlizszN NVv3ZnVZW0GQR1XS
SW1573 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGXwTJFKSzVyPUCuNFU5ODJizszN NWHiWWt5W0GQR1XS
SCC-9 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX;JR|UxRTBwMEW4O{DPxE1? M1fKZnNCVkeHUh?=
MDA-MB-361 NGjSfJdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoHLTWM2OD1yLkC1PFczKM7:TR?= MXXTRW5ITVJ?
BHT-101 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4[4XWlEPTB;MD6wOVg4PiEQvF2= M1vJSHNCVkeHUh?=
NCI-H1770 NILqVYdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF;DVWFKSzVyPUCuNFU5PzlizszN Mom4V2FPT0WU
UACC-893 M{T1bmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1\sOGlEPTB;MD6wOVg6PiEQvF2= MWXTRW5ITVJ?
NCI-H226 M4jobGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGTESG1KSzVyPUCuNFU6QDhizszN MXXTRW5ITVJ?
HLE M2jpW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{jBeWlEPTB;MD6wOlA5OiEQvF2= MXrTRW5ITVJ?
NCI-H1703 M2Xofmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHfkc29KSzVyPUCuNFYyPzhizszN MmT1V2FPT0WU
KURAMOCHI NE[yN3hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1nwbWlEPTB;MD6wOlE5QSEQvF2= NGixPXJUSU6JRWK=
RH-1 Mle4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYHJR|UxRTBwME[yN{DPxE1? Ml\2V2FPT0WU
DSH1 Mm\GS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml;hTWM2OD1yLkC2Nlch|ryP NGDRdlNUSU6JRWK=
CAMA-1 M4LLOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF;SclBKSzVyPUCuNFY{ODNizszN NV\1ZnB1W0GQR1XS
NCI-H1437 NF32TVVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWDJR|UxRTBwME[zNlgh|ryP Mmn5V2FPT0WU
HuP-T4 MmO5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXr5WnFMUUN3ME2wMlA3PTh4IN88US=> MVHTRW5ITVJ?
HCT-15 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4LoNmlEPTB;MD6wOlU6PyEQvF2= NUn2WphbW0GQR1XS
NCCIT NWPBNI9lT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXvVXGV3UUN3ME2wMlA3PjB2IN88US=> NX70UJNzW0GQR1XS
BOKU MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF\1bHdKSzVyPUCuNFY3PzRizszN NW\6[YFUW0GQR1XS
FADU M37TSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3TlfGlEPTB;MD6wOlc1PSEQvF2= MVzTRW5ITVJ?
SUP-T1 M{HQd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUTJR|UxRTBwME[3OkDPxE1? MVLTRW5ITVJ?
L-363 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoDMTWM2OD1yLkC2PVAyKM7:TR?= NGPYN4pUSU6JRWK=
KNS-81-FD MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4fjU2lEPTB;MD6wOlkyQCEQvF2= MWXTRW5ITVJ?
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MDA-MB-157 Mnq5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MorhTWM2OD13Lk[2OFQ{KM7:TR?= Ml\GV2FPT0WU
NCI-H1623 MofPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4\ZOWlEPTB;NT64N|U2PiEQvF2= NG\DNmpUSU6JRWK=
RPMI-8866 NUfacmdFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIKyOZRKSzVyPUWuPFQ4QTJizszN MWnTRW5ITVJ?
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NCI-H322M MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFPPTnlKSzVyPUmuNVYzQDFizszN M2\INXNCVkeHUh?=
NCI-H187 M1HVXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXjJR|UxRTlwNUG4N|Uh|ryP NG\EZ5JUSU6JRWK=
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... Click to View More Cell Line Experimental Data

In vivo Treatment with NVP-AUY922 causes a robust antitumor response and inhibits p-Akt and VEGF expression in an HSC-2 xenograft model. [2] In BT474, NVP-AUY922 shows complete loss of ERBB2 and substantial depletion of ERα, in addition to reductions in CDK4 and phospho-ERK1/2. [3]

Protocol

Kinase Assay:[3]
+ Expand

Kinase assay:

NVP-AUY922 is dissolved in DMSO at a concentration of 10 mM. NVP-AUY922 is assessed against HSP90α, HSP90β, GRP94, TRAP-1, HSP72, and topoisomerase II. Profiling against a panel of kinases has been carried out and screening against a panel of additional enzymes and receptors is performed at Cerep.
Cell Research:[1]
+ Expand
  • Cell lines: Human gastric cancer cells NCI-N87
  • Concentrations: 1 μM
  • Incubation Time: 3 days
  • Method: Human gastric cancer cells NCI-N87 (5-7 ×103 in 50 μL/well) are seeded in 96-well plates and incubated at 37 °C for 24 hours, followed by NVP-AUY922 treatment for 1-3 days at 37 °C. After treatment, the cells are assayed by MTT method and analyzed by microplate reader.
    (Only for Reference)
Animal Research:[3]
+ Expand
  • Animal Models: Female NCr athymic mice bearing WM266.4 human melanoma xenografts
  • Formulation: In DMSO and diluted in sterile saline/Tween 20
  • Dosages: 50 mg/kg
  • Administration: Administered via i.v. or i.p.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 93 mg/mL (199.76 mM) warming
Ethanol 31 mg/mL (66.58 mM)
Water <1 mg/mL
In vivo 1% DMSO+30% polyethylene glycol+1% Tween 80 30 mg/mL

* 1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 465.54
Formula

C26H31N3O5

CAS No. 747412-49-3
Storage powder
in solvent
Synonyms VER-52296

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
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Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT01784640 Active, not recruiting Recurrent Non-small Cell Lung Cancer|Squamous Cell Lung Cancer|Stage IV Non-small Cell Lung Cancer Jonsson Comprehensive Cancer Center|National Cancer Institute (NCI) January 2014 Phase 1
NCT01922583 Active, not recruiting Non-small Cell Lung Cancer (NSCLC) National Taiwan University Hospital January 2014 Phase 2
NCT01854034 Active, not recruiting Non Small Cell Lung Cancer Massachusetts General Hospital July 2013 Phase 2
NCT01772797 Completed Anaplastic Lymphoma Kinase (ALK)|Non-small Cell Lung Cancer Novartis Pharmaceuticals|Novartis June 2013 Phase 1
NCT01752400 Active, not recruiting Non Small Cell Lung Cancer Massachusetts General Hospital January 2013 Phase 2
NCT01613950 Completed Stomach Neoplasms Esophageal Neoplasms Metastatic Gastric Cancer Mutated PI3KCA Protein Overexpressed HER2 Protein Novartis Pharmaceuticals|Novartis December 2012 Phase 1

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

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HSP (e.g. HSP90) Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID