Luminespib (AUY-922, NVP-AUY922)

Catalog No.S1069 Synonyms: VER-52296

Luminespib (AUY-922, NVP-AUY922) Chemical Structure

Molecular Weight(MW): 465.54

Luminespib (AUY-922, NVP-AUY922) is a highly potent HSP90 inhibitor for HSP90α/β with IC50 of 13 nM /21 nM in cell-free assays, weaker potency against the HSP90 family members GRP94 and TRAP-1, exhibits the tightest binding of any small-molecule HSP90 ligand. Phase 2.

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In DMSO USD 320 In stock
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3 Customer Reviews

  • U2OS_exo cells were incubated with AUY922 for 20 h at the indicated concentrations before stimulation with TNFα (30 ng/mL) for 30 min and immunostaining to detect NF-κB (p65). DMSO 1%, cells stimulated by TNFα in the absence of AUY922. Representative pictures used to quantify nuclear and cytoplasmic localization of NF-κB.

    Proc Natl Acad Sci USA, 2014, 111(15): E1528–37 . Luminespib (AUY-922, NVP-AUY922) purchased from Selleck.

    J Biol Chem 2013 288(23), 16308-20. Luminespib (AUY-922, NVP-AUY922) purchased from Selleck.

  • Western blots show the molecular signature of HSP90 inhibition by NVP-AUY922  (ie, induction of HSP72 and depletion of client proteins such as ERBB2, CRAF and CDK4) in BT474 breast cancer cell line. GAPDH was used as loading control.

     

     

    2011 Dr. Swee Sharp and Professor Paul Workman from Cancer Research UK. Luminespib (AUY-922, NVP-AUY922) purchased from Selleck.

Purity & Quality Control

Choose Selective HSP (e.g. HSP90) Inhibitors

Biological Activity

Description Luminespib (AUY-922, NVP-AUY922) is a highly potent HSP90 inhibitor for HSP90α/β with IC50 of 13 nM /21 nM in cell-free assays, weaker potency against the HSP90 family members GRP94 and TRAP-1, exhibits the tightest binding of any small-molecule HSP90 ligand. Phase 2.
Targets
HSP90α [1]
(Cell-free assay)
HSP90β [1]
(Cell-free assay)
13 nM 21 nM
In vitro

NVP-AUY922 inhibits proliferation of various human cancer cell lines in vitro, with an average GI50 of 9 nM. [1] The IC50 values of NVP-AUY922 fall in the range of 2 to 40 nM in these gastric cancer cell lines. IC50 value for the BEAS-2B cells is 28.49 nM. Treatment with NVP-AUY922 does not influence the expression of HSP90, but expression of HSP70 gets elevated by NVP-AUY922 treatment. NVP-AUY922 increases the binding of HSP70 to HSP90. NVP-AUY922 causes p23 dissociation from the HSP90 complex and can then recruit HSP70 to the HSP90 complex. [1] After the treatment with NVP-AUY922, expression of receptor tyrosine kinases including VEGFR1, 2, 3 and PDGFRɑ is decreased. A decrease is also noticed in the expression of Akt and phospho-Akt. Meanwhile, treatment with NVP-AUY922 causes decreased expression of HER-2 in NCI-N87 cells. NVP-AUY922 treatment results in binding of HSP90 to client proteins and setting them up as targets for degradation by the proteasome. NVP-AUY922 can influence cell growth by affecting multiple signaling pathways. In addition, treatment with the proteasome inhibitor, MG132, restores expression of thymidylate synthase, which is decreased by NVP-AUY922. NVP-AUY922 increases the expression of cleaved caspase-3 leading to apoptosis in HSC-2 cells.[1]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
CMK MkjLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkPiTWM2OD1yLkCwNFEzPSEQvF2= M1;hOHNCVkeHUh?=
MV-4-11 NGTh[VBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX;JR|UxRTBwMECwOVU5KM7:TR?= MnXLV2FPT0WU
NALM-6 NFjSdHBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWHJR|UxRTBwMECwPFQzKM7:TR?= MV7TRW5ITVJ?
HOS NYm2NXBuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFfKRnJKSzVyPUCuNFAyOzhizszN MoXwV2FPT0WU
HT-144 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmLITWM2OD1yLkCwNVU2KM7:TR?= NHHpR2VUSU6JRWK=
SW1710 NHTTSmhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV\JR|UxRTBwMECxPFYh|ryP Mk\0V2FPT0WU
TE-8 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NU\GN4F4UUN3ME2wMlAxOjN5IN88US=> NGfhc4xUSU6JRWK=
ES1 Mln6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX:xR|hOUUN3ME2wMlAxOjZ4IN88US=> NUe0OJhOW0GQR1XS
CCF-STTG1 MnHMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M13FNWlEPTB;MD6wNFI6PyEQvF2= MXnTRW5ITVJ?
PSN1 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3rONmlEPTB;MD6wNFMyQCEQvF2= NXj0VnNHW0GQR1XS
CAL-51 NY\zflNkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF7XcVZKSzVyPUCuNFA{OjVizszN MWfTRW5ITVJ?
MCF7 M{XiV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnjlTWM2OD1yLkCwN|M2KM7:TR?= MkfTV2FPT0WU
SK-HEP-1 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NETQbYJKSzVyPUCuNFA{OzZizszN NXn5[|dZW0GQR1XS
LCLC-103H MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVXJR|UxRTBwMEC0N{DPxE1? MW\TRW5ITVJ?
HMV-II MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYnJR|UxRTBwMEC0OFkh|ryP NHfpcXpUSU6JRWK=
MES-SA M2\XOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV7JR|UxRTBwMEC0OVIh|ryP NV3TdGd2W0GQR1XS
SK-LMS-1 NYjM[ZZoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXLJR|UxRTBwMEC0OVgh|ryP M3PIcHNCVkeHUh?=
639-V MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYLJR|UxRTBwMEC0PFUh|ryP NF3kT2NUSU6JRWK=
SIG-M5 M330cGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEHJ[otKSzVyPUCuNFA1QDlizszN NXXie|FqW0GQR1XS
LOUCY MoXOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV7zN5pFUUN3ME2wMlAxPTB3IN88US=> NE\nVW1USU6JRWK=
HSC-2 M3jyTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX\JR|UxRTBwMEC1NVgh|ryP MXjTRW5ITVJ?
EW-13 M1nueGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3O1cWlEPTB;MD6wNFUyQCEQvF2= M2r2V3NCVkeHUh?=
RT-112 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4PBPWlEPTB;MD6wNFU{PSEQvF2= M{jTZnNCVkeHUh?=
NKM-1 NYXKNmN7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXvJR|UxRTBwMEC1OFch|ryP NILyUIdUSU6JRWK=
KYSE-180 M{mxRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MonyTWM2OD1yLkCwOVg3KM7:TR?= NG\FdY9USU6JRWK=
SW1783 NX\xNVdyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGDnRoRKSzVyPUCuNFA2QTFizszN M4nEenNCVkeHUh?=
A431 NY\TNIp3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4\qdWlEPTB;MD6wNFYxPyEQvF2= MlTOV2FPT0WU
SK-OV-3 MoDzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGLzeYhKSzVyPUCuNFA3OyEQvF2= M2Ln[3NCVkeHUh?=
RPMI-7951 NH7OV4tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2PWdmlEPTB;MD6wNFY{OSEQvF2= NIP1fW5USU6JRWK=
Capan-2 M4HoSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml\rTWM2OD1yLkCwOlM5KM7:TR?= M2jqbHNCVkeHUh?=
HSC-3 NXfrOZJkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH\uRlNKSzVyPUCuNFA3PDFizszN MX\TRW5ITVJ?
786-0 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2LqdmlEPTB;MD6wNFY3OyEQvF2= NG\a[W1USU6JRWK=
Daoy M1znbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXfJR|UxRTBwMEC2PVUh|ryP MnvTV2FPT0WU
KGN MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MorLTWM2OD1yLkCwO|A{KM7:TR?= NG\hfmFUSU6JRWK=
EW-16 NUDHWlNWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVLpeZYxUUN3ME2wMlAxPzR7IN88US=> Mlz6V2FPT0WU
EW-7 NYrPd4ZzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUPJR|UxRTBwMEC3OVQh|ryP M2jvZnNCVkeHUh?=
IGROV-1 NFzoNoZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn7PTWM2OD1yLkCwPFE1KM7:TR?= M3SwN3NCVkeHUh?=
8505C MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEPOZ2hKSzVyPUCuNFA5OjFizszN MYrTRW5ITVJ?
RKO NXfWSlJPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mnv3TWM2OD1yLkCwPFI3KM7:TR?= M4TFdHNCVkeHUh?=
GDM-1 M{\0R2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXvJR|UxRTBwMEC4OEDPxE1? NXi0TYY5W0GQR1XS
IST-MEL1 NUfsR3pLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYnqS4puUUN3ME2wMlAxQDV{IN88US=> NHG1R2hUSU6JRWK=
RPMI-6666 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUjteVF2UUN3ME2wMlAxQDV{IN88US=> NUjERlB7W0GQR1XS
SNG-M M13xdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mo\RTWM2OD1yLkCwPFU3KM7:TR?= MmDVV2FPT0WU
KS-1 MnHYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2jYW2lEPTB;MD6wNFg2QSEQvF2= NU\6R3ZnW0GQR1XS
RXF393 M3Oycmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYXJR|UxRTBwMEC4OkDPxE1? NFPWfXZUSU6JRWK=
CAL-12T NVfPWVROT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHrPO3FKSzVyPUCuNFA6OjJizszN MnXZV2FPT0WU
BFTC-905 NVO5XnB1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEXDXGVKSzVyPUCuNFA6OzhizszN MlfSV2FPT0WU
SK-MES-1 M2jWPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmTsTWM2OD1yLkCwPVQ2KM7:TR?= NWCy[ow{W0GQR1XS
BB30-HNC NWfy[o5ET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MY\JR|UxRTBwMEC5OVIh|ryP MmqwV2FPT0WU
AN3-CA MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnzkTWM2OD1yLkCxNFE4KM7:TR?= MVLTRW5ITVJ?
EFO-27 NWnETIxPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkDKTWM2OD1yLkCxNFE4KM7:TR?= MmS0V2FPT0WU
G-401 NGTCNnFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGTLUFVKSzVyPUCuNFExOjVizszN NFn1[olUSU6JRWK=
BPH-1 NY\BN4ZHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYrRVlgyUUN3ME2wMlAyODNizszN MkL0V2FPT0WU
NCI-H727 NID4bIZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2e3cGlEPTB;MD6wNVA{KM7:TR?= M1jsdHNCVkeHUh?=
SNU-423 M1LiT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV3MWGtCUUN3ME2wMlAyODV|IN88US=> NXPzOZhqW0GQR1XS
KYSE-270 MojSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M172XWlEPTB;MD6wNVA2QSEQvF2= MnraV2FPT0WU
AGS MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoLlTWM2OD1yLkCxNFYyKM7:TR?= NIXMUoRUSU6JRWK=
NCI-H2228 NV3Lco1OT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEL2OlhKSzVyPUCuNFExPjRizszN M1zZSHNCVkeHUh?=
SW954 NEHOS2FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1TNNGlEPTB;MD6wNVA4OSEQvF2= NWXVPXVGW0GQR1XS
769-P M1viNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYPJR|UxRTBwMEGwO|Mh|ryP NXL0bI1{W0GQR1XS
BB49-HNC NX7EXnIzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MorFTWM2OD1yLkCxNFc4KM7:TR?= NVfxNZdvW0GQR1XS
IA-LM MlO0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{TrTWlEPTB;MD6wNVA5PiEQvF2= NUHRRlgyW0GQR1XS
NB69 NHG0fIlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NI[xSVRKSzVyPUCuNFEyODJizszN NYjqcVdtW0GQR1XS
C8166 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3n0TWlEPTB;MD6wNVEzQSEQvF2= NWD6dGdlW0GQR1XS
NCI-H1299 M3nNTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHfRSo5KSzVyPUCuNFEyPTRizszN MYfTRW5ITVJ?
YKG-1 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2XaNWlEPTB;MD6wNVE3KM7:TR?= NUjrUlhPW0GQR1XS
PANC-03-27 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYHJR|UxRTBwMEGxOlIh|ryP MnzKV2FPT0WU
YT NEj6dIlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2\zPGlEPTB;MD6wNVE4QSEQvF2= MWTTRW5ITVJ?
CAL-85-1 Mo\nS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MU\JR|UxRTBwMEGxPVIh|ryP M1jIWXNCVkeHUh?=
GT3TKB MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1\yPGlEPTB;MD6wNVIxOiEQvF2= NUfSb|M1W0GQR1XS
BB65-RCC MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mk[4TWM2OD1yLkCxNlA1KM7:TR?= M{jvOnNCVkeHUh?=
ES6 NVq4TXp2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFPNPXlKSzVyPUCuNFEzPjFizszN MmrJV2FPT0WU
MHH-ES-1 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M13rNWlEPTB;MD6wNVI3OyEQvF2= M2nE[HNCVkeHUh?=
QIMR-WIL MkXsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlvCTWM2OD1yLkCxNlY6KM7:TR?= MXjTRW5ITVJ?
SNU-C2B NFHpNmVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFj5VmpKSzVyPUCuNFEzPzJizszN MkfQV2FPT0WU
OCI-AML2 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF\2VFZKSzVyPUCuNFEzQDFizszN NGjNXoVUSU6JRWK=
DU-145 Mnm5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3Kyb2lEPTB;MD6wNVI6KM7:TR?= M{\sZnNCVkeHUh?=
SW982 MnvKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4C0dGlEPTB;MD6wNVI6OyEQvF2= M3nNOnNCVkeHUh?=
MFH-ino NWqxPY5tT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUfJR|UxRTBwMEGyPVMh|ryP NHjES3BUSU6JRWK=
A427 M2LpdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXrJR|UxRTBwMEGyPVkh|ryP MnX0V2FPT0WU
LCLC-97TM1 M3jBWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX3JR|UxRTBwMEGzJO69VQ>? MWPTRW5ITVJ?
AM-38 NH36T4JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX73XmR2UUN3ME2wMlAyOzB{IN88US=> MnTZV2FPT0WU
K5 M{P5W2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MofyTWM2OD1yLkCxN|A5KM7:TR?= NXvIcGVvW0GQR1XS
T84 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmC3TWM2OD1yLkCxN|MyKM7:TR?= M{S4XHNCVkeHUh?=
TE-15 MmL0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NILSNndKSzVyPUCuNFE{OzZizszN NFvOeZNUSU6JRWK=
NCI-H460 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWG4UWN7UUN3ME2wMlAyOzN4IN88US=> MXzTRW5ITVJ?
NTERA-S-cl-D1 NGLpeG9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnjyTWM2OD1yLkCxN|M6KM7:TR?= NFX1bmhUSU6JRWK=
KYSE-450 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVjlSYdnUUN3ME2wMlAyOzR7IN88US=> MUPTRW5ITVJ?
H4 NWDHZ4tmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVrJR|UxRTBwMEGzOlYh|ryP MWjTRW5ITVJ?
LC-2-ad MnzDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmjITWM2OD1yLkCxN|ch|ryP M{\JOXNCVkeHUh?=
GAMG NF3qU2ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MorNTWM2OD1yLkCxN|cyKM7:TR?= NHHLNGdUSU6JRWK=
TK10 Ml74S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{HKbmlEPTB;MD6wNVM5OiEQvF2= MkLLV2FPT0WU
NCI-H2122 NVy5PIpyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mln2TWM2OD1yLkCxN|g1KM7:TR?= MWfTRW5ITVJ?
KM12 NWHGOmhNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYDJR|UxRTBwMEGzPVkh|ryP Ml\PV2FPT0WU
CAL-39 NY\GRYJ3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mk\ITWM2OD1yLkCxOFIh|ryP NFHwNJhUSU6JRWK=
RPMI-2650 M2H2e2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4H0XmlEPTB;MD6wNVQ{OiEQvF2= Mm\YV2FPT0WU
KYSE-510 NXr3O5dYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFW1SXVKSzVyPUCuNFE1PDJizszN M1L0[XNCVkeHUh?=
KALS-1 MkGyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXy4XZNoUUN3ME2wMlAyPDZ4IN88US=> M4nvTXNCVkeHUh?=
NCI-H1648 M2\pcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYjJR|UxRTBwMEG0PVkh|ryP NV3OS4V2W0GQR1XS
ES4 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHyxbphKSzVyPUCuNFE2ODJizszN Mo\SV2FPT0WU
C-33-A M3\uVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml61TWM2OD1yLkCxOVA6KM7:TR?= M{\xeXNCVkeHUh?=
MIA-PaCa-2 NUniWItqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUfJR|UxRTBwMEG1NFkh|ryP M3LBcHNCVkeHUh?=
Becker MnfJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGXXXFFKSzVyPUCuNFE2OTRizszN M{jyeXNCVkeHUh?=
HOP-62 NG\Ld4tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIHH[GlKSzVyPUCuNFE2PDJizszN M{XzbHNCVkeHUh?=
TE-1 M3\2R2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MojlTWM2OD1yLkCxOVgyKM7:TR?= NFjqVo1USU6JRWK=
KYSE-410 M1GwXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFvhdJJKSzVyPUCuNFE2QDZizszN NHrYe|VUSU6JRWK=
NOS-1 M3;Tc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{XxVGlEPTB;MD6wNVU6OyEQvF2= MWTTRW5ITVJ?
MEL-HO MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWXOeXBUUUN3ME2wMlAyPjR|IN88US=> NHXKZW9USU6JRWK=
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VMRC-RCZ MnvDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUjJR|UxRTBwMEG2OVEh|ryP MnPVV2FPT0WU
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JiyoyeP-2003 M3L3bmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVTFe5V4UUN3ME2wMlA{Ozh6IN88US=> MlTQV2FPT0WU
BL-70 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGTYSVBKSzVyPUCuNFM{QDlizszN NVzrXpZMW0GQR1XS
OS-RC-2 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MljwTWM2OD1yLkCzN|k3KM7:TR?= MVnTRW5ITVJ?
SF268 NYDkeIRbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX3k[HhsUUN3ME2wMlA{PDBzIN88US=> NXf1WJpOW0GQR1XS
BV-173 NHPFSHBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3HNc2lEPTB;MD6wN|QzPiEQvF2= MlzsV2FPT0WU
DMS-273 MnjtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHfXb45KSzVyPUCuNFM1PzlizszN MVzTRW5ITVJ?
22RV1 NXXYdJNnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{HTPWlEPTB;MD6wN|UxPyEQvF2= MkW3V2FPT0WU
ES8 NWTHTJNmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NI\x[YpKSzVyPUCuNFM2OzhizszN NFfNT2RUSU6JRWK=
KYSE-150 NVTscYFJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnHHTWM2OD1yLkCzOlA5KM7:TR?= NIHifGtUSU6JRWK=
HCC1569 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX3IfoJqUUN3ME2wMlA{PjB6IN88US=> NWrlVlFmW0GQR1XS
NB5 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXW5TJh5UUN3ME2wMlA{PjF|IN88US=> MnXjV2FPT0WU
G-402 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{ntZWlEPTB;MD6wN|YyPCEQvF2= MljJV2FPT0WU
NCI-H1693 M3viOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFPWVW5KSzVyPUCuNFM3OTdizszN MmnwV2FPT0WU
LB2241-RCC NHuzNnFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2XUbmlEPTB;MD6wN|Y1OiEQvF2= MVPTRW5ITVJ?
KP-4 NHy1NGZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MU\JR|UxRTBwMEO2OlMh|ryP NGLMTmxUSU6JRWK=
ML-2 NYDub20xT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXyyXJVZUUN3ME2wMlA{PjdzIN88US=> NHTIR3BUSU6JRWK=
KU812 MnjlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYHJR|UxRTBwMEO2PFQh|ryP M1\4UXNCVkeHUh?=
LS-411N MlLwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUDJR|UxRTBwMEO3N|Eh|ryP MmXDV2FPT0WU
OAW-42 NGXOPZFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml\QTWM2OD1yLkCzO|Q4KM7:TR?= MmHOV2FPT0WU
HCC38 NEX5WFhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVrJR|UxRTBwMEO3O|Eh|ryP M3vrWHNCVkeHUh?=
Ca-Ski MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1XjR2lEPTB;MD6wN|c5PCEQvF2= MkC0V2FPT0WU
Calu-3 M{XFPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYTIWGNOUUN3ME2wMlA{Pzh7IN88US=> NH62fG5USU6JRWK=
KYSE-70 M1T2cmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUXze3BJUUN3ME2wMlA{QDF{IN88US=> MlfWV2FPT0WU
D-392MG MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHjmVlFKSzVyPUCuNFM5PDJizszN NWTOe3Z1W0GQR1XS
OVCAR-4 NHO4NVRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVvJR|UxRTBwMEO4OVgh|ryP NWjQc3N4W0GQR1XS
Detroit562 MkexS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEG5N5lKSzVyPUCuNFM5PzJizszN MVrTRW5ITVJ?
HEL M17NTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIKz[|lKSzVyPUCuNFM5QTFizszN NU\vW2lGW0GQR1XS
MONO-MAC-6 NUTZVWJRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWHjdpdXUUN3ME2wMlA{QDl|IN88US=> MWXTRW5ITVJ?
LoVo M{LyUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NETCOYRKSzVyPUCuNFM6OzNizszN M3zHZXNCVkeHUh?=
U-2-OS NV71cWVqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3XpOmlEPTB;MD6wN|k{PSEQvF2= NFPGeXdUSU6JRWK=
A172 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M17nZmlEPTB;MD6wN|k2KM7:TR?= NEnzb3VUSU6JRWK=
OCUB-M M1rFcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4\OfmlEPTB;MD6wN|k3OSEQvF2= M4fiSHNCVkeHUh?=
SW48 NVPVZ3l6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NITUepFKSzVyPUCuNFQxOzFizszN NU\JVWVTW0GQR1XS
HC-1 M4XlSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1XXdGlEPTB;MD6wOFA3QSEQvF2= M{G3T3NCVkeHUh?=
KOSC-2 MnjmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2nDPWlEPTB;MD6wOFEyKM7:TR?= MnHEV2FPT0WU
HDLM-2 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3yxbWlEPTB;MD6wOFEyPCEQvF2= MULTRW5ITVJ?
CTV-1 M{LTWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mnf2TWM2OD1yLkC0NVE3KM7:TR?= M{jCXHNCVkeHUh?=
SH-4 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3LDNmlEPTB;MD6wOFE1OSEQvF2= MXLTRW5ITVJ?
SW756 M{LQN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIjoXmNKSzVyPUCuNFQyPTdizszN Mo\lV2FPT0WU
GCT MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mnn0TWM2OD1yLkC0NVYyKM7:TR?= MX;TRW5ITVJ?
CHL-1 NWOxTXJNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYn4Uo1YUUN3ME2wMlA1OTZ7IN88US=> NXPvdnBbW0GQR1XS
LAMA-84 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXe0OYgzUUN3ME2wMlA1OTdzIN88US=> MofLV2FPT0WU
LS-1034 Mn25S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXvJR|UxRTBwMESxPVEh|ryP M2TPbXNCVkeHUh?=
NCI-H358 M1ftTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWfPbI9DUUN3ME2wMlA1OjF{IN88US=> M2Lx[HNCVkeHUh?=
NB13 MneyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoPhTWM2OD1yLkC0NlI4KM7:TR?= NFy4[2RUSU6JRWK=
TE-9 MlHES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{PsbGlEPTB;MD6wOFI{PyEQvF2= M3jSZXNCVkeHUh?=
OE33 M13nXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWrJR|UxRTBwMESyOFEh|ryP NG[0UHdUSU6JRWK=
CAL-120 Ml[2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1vsUGlEPTB;MD6wOFI1OSEQvF2= MVrTRW5ITVJ?
DJM-1 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFnyRYdKSzVyPUCuNFQzPzJizszN NUnGfIU2W0GQR1XS
SK-MEL-24 Mn;BS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NELOR3lKSzVyPUCuNFQzQDNizszN NXjWVGRkW0GQR1XS
VA-ES-BJ M1f1Nmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFrNPY5KSzVyPUCuNFQzQTJizszN NVq1O|FzW0GQR1XS
MMAC-SF M4HkZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1nKV2lEPTB;MD6wOFI6PyEQvF2= M2TCUnNCVkeHUh?=
MZ7-mel NGDZSpFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmnLTWM2OD1yLkC0N|Mh|ryP MlfEV2FPT0WU
BxPC-3 MkDRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIm2NXZKSzVyPUCuNFQ{PDFizszN MXvTRW5ITVJ?
HT-29 NWfjfGM4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml;PTWM2OD1yLkC0N|U4KM7:TR?= NFTPNXFUSU6JRWK=
SK-MEL-30 NX3UTmN5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYLWVnNRUUN3ME2wMlA1OzZ{IN88US=> MU\TRW5ITVJ?
CAL-33 NEHwSnNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVzJR|UxRTBwMESzO|Uh|ryP MXjTRW5ITVJ?
COLO-680N NFXjcmRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MY\JR|UxRTBwMES0NFch|ryP NVjZ[nVmW0GQR1XS
NH-12 MmfGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1fyT2lEPTB;MD6wOFQ1KM7:TR?= NV;O[lgyW0GQR1XS
HCC1937 NUDEU2h5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoXITWM2OD1yLkC0OFU3KM7:TR?= NHzvS4VUSU6JRWK=
IMR-5 Mn\6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWfmclN7UUN3ME2wMlA1PDlizszN Ml3LV2FPT0WU
MC-CAR MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFjh[odKSzVyPUCuNFQ2PjlizszN MW\TRW5ITVJ?
NCI-H747 MmS2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV;3XIZWUUN3ME2wMlA1PTdizszN MnS0V2FPT0WU
NCI-H1792 NXPocld1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEXDTmJKSzVyPUCuNFQ2QDFizszN NHXHelJUSU6JRWK=
SW13 NGnudINIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFvUZVFKSzVyPUCuNFQ2QSEQvF2= NHf4VWpUSU6JRWK=
MLMA NY\GVnVMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFrZS3pKSzVyPUCuNFQ3ODlizszN MkPGV2FPT0WU
U251 MmjZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWTJR|UxRTBwMES3OlMh|ryP MWDTRW5ITVJ?
U031 NWPRZ21zT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWDJR|UxRTBwMES3O|Eh|ryP M2flbHNCVkeHUh?=
ME-180 NHjMVGlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3X6UmlEPTB;MD6wOFc5OiEQvF2= MVPTRW5ITVJ?
SK-MEL-3 NX\Kc|VjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmDjTWM2OD1yLkC0PFAzKM7:TR?= MVrTRW5ITVJ?
MOLT-4 NGroV5dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVLJR|UxRTBwMES4NFMh|ryP NWnyNI5xW0GQR1XS
PF-382 Mk[wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXfYdohyUUN3ME2wMlA1QDJ4IN88US=> MYHTRW5ITVJ?
NUGC-3 NUnER2xnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV3JR|UxRTBwMES4Nlch|ryP NHXkTYRUSU6JRWK=
NCI-H1417 NFjGWFBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXXJR|UxRTBwMES4PUDPxE1? NULLTYpMW0GQR1XS
COLO-205 M3O1OWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoXuTWM2OD1yLkC0PVE6KM7:TR?= M4XTRnNCVkeHUh?=
TE-441-T M4H3bWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWTJR|UxRTBwMES5N{DPxE1? Mn\PV2FPT0WU
MKN1 M2jpbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXTJR|UxRTBwMES5N{DPxE1? Mkm0V2FPT0WU
UM-UC-3 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFnvSppKSzVyPUCuNFQ6PSEQvF2= M3nCUHNCVkeHUh?=
SF126 NXS1SHNFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVPwT5h{UUN3ME2wMlA2ODFizszN MmL3V2FPT0WU
LB1047-RCC NVLNbnhtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX7JR|UxRTBwMEWwN|Eh|ryP NH3vV4tUSU6JRWK=
A253 NEewU2hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NES4VWdKSzVyPUCuNFUxPTJizszN MorBV2FPT0WU
NCI-H1963 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoezTWM2OD1yLkC1NVc3KM7:TR?= NF3iVphUSU6JRWK=
VM-CUB-1 MkDCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYTJR|UxRTBwMEWzNVEh|ryP M1nlRnNCVkeHUh?=
T-24 NWLHbGJRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlK5TWM2OD1yLkC1N|g1KM7:TR?= NVfvTXBYW0GQR1XS
K-562 M4rBPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2nrXmlEPTB;MD6wOVM5PyEQvF2= NH7L[mRUSU6JRWK=
ARH-77 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF72N4lKSzVyPUCuNFU{QTVizszN MnTnV2FPT0WU
CA46 MnvjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUjJR|UxRTBwMEW0N{DPxE1? NGnZeJhUSU6JRWK=
HCC70 NFi0eZZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmnSTWM2OD1yLkC1OFUzKM7:TR?= NIPFdWhUSU6JRWK=
ST486 NV\QdJZVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4nHWGlEPTB;MD6wOVUzPSEQvF2= MnjRV2FPT0WU
COLO-741 NF\a[pFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVPMNoxVUUN3ME2wMlA2PTNzIN88US=> MoHkV2FPT0WU
SK-PN-DW NF\uNnZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYrJbmlRUUN3ME2wMlA2PTh6IN88US=> MlXGV2FPT0WU
BL-41 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVvuN5ZtUUN3ME2wMlA2PTl4IN88US=> MkmyV2FPT0WU
D-263MG M1jaS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV7JR|UxRTBwMEW2PFMh|ryP MnryV2FPT0WU
KE-37 NHv6XXlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmDYTWM2OD1yLkC1Olg{KM7:TR?= MXvTRW5ITVJ?
LU-134-A M1jtdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFzQTlNKSzVyPUCuNFU4OTVizszN MYLTRW5ITVJ?
HCC2157 NGnwVIhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHe4PWFKSzVyPUCuNFU4OzNizszN NU\zTHpGW0GQR1XS
GAK NUX1W|Z3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWfJR|UxRTBwMEW3N|Qh|ryP MYDTRW5ITVJ?
IST-SL2 M1GxeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYjJR|UxRTBwMEW3OFMh|ryP M1XU[3NCVkeHUh?=
KMOE-2 NEH2W3RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWnqN|doUUN3ME2wMlA2PzR7IN88US=> MXPTRW5ITVJ?
SW1573 NH31bZdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH74NJRKSzVyPUCuNFU5ODJizszN NYjieplEW0GQR1XS
SCC-9 NEDhRXBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2\NVGlEPTB;MD6wOVg4KM7:TR?= MUDTRW5ITVJ?
MDA-MB-361 M1izT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1LBNGlEPTB;MD6wOVg4OiEQvF2= MmDMV2FPT0WU
BHT-101 M1X2VGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4S5NmlEPTB;MD6wOVg4PiEQvF2= MV;TRW5ITVJ?
NCI-H1770 M1HzcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoHZTWM2OD1yLkC1PFc6KM7:TR?= MWTTRW5ITVJ?
UACC-893 MojpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHjCcYVKSzVyPUCuNFU5QTZizszN NYj4d5NWW0GQR1XS
NCI-H226 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHrZWJBKSzVyPUCuNFU6QDhizszN MXzTRW5ITVJ?
HLE NUT0NG1[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoLoTWM2OD1yLkC2NFgzKM7:TR?= MnvvV2FPT0WU
NCI-H1703 NVXDbW1sT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXHJR|UxRTBwME[xO|gh|ryP NGjRRWVUSU6JRWK=
KURAMOCHI M1nNZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFXKW49KSzVyPUCuNFYyQDlizszN Ml7zV2FPT0WU
RH-1 NYDtU3dpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmDBTWM2OD1yLkC2NlMh|ryP MWrTRW5ITVJ?
DSH1 M3fQWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{HVUmlEPTB;MD6wOlI4KM7:TR?= MYXTRW5ITVJ?
CAMA-1 NXXGTnd6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1vLWmlEPTB;MD6wOlMxOyEQvF2= M4jSc3NCVkeHUh?=
NCI-H1437 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn;BTWM2OD1yLkC2N|I5KM7:TR?= MVfTRW5ITVJ?
HuP-T4 MmnOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVL4c|JZUUN3ME2wMlA3PTh4IN88US=> M1vZW3NCVkeHUh?=
HCT-15 MlfJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlToTWM2OD1yLkC2OVk4KM7:TR?= NWnHO5dlW0GQR1XS
NCCIT M1jmPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX6zR4hlUUN3ME2wMlA3PjB2IN88US=> M2rYN3NCVkeHUh?=
BOKU M4T4b2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlHOTWM2OD1yLkC2Olc1KM7:TR?= NFL3PFZUSU6JRWK=
FADU MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXHaUpczUUN3ME2wMlA3PzR3IN88US=> NF3JT|dUSU6JRWK=
SUP-T1 NYHFb|ZZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVjJR|UxRTBwME[3OkDPxE1? Mmi2V2FPT0WU
L-363 MkOzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{HtNmlEPTB;MD6wOlkxOSEQvF2= MlrlV2FPT0WU
KNS-81-FD MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGHjO|RKSzVyPUCuNFY6OThizszN MXnTRW5ITVJ?
SU-DHL-1 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGLNbYxKSzVyPUCuNFY6OiEQvF2= M2n2dXNCVkeHUh?=
HuH-7 M4TEWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWjJR|UxRTBwMEewN|Uh|ryP MVnTRW5ITVJ?
BT-474 Ml:xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWLTPHI4UUN3ME2wMlA4ODZzIN88US=> NYnNTo5IW0GQR1XS
CAPAN-1 MkLqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXi2T4s6UUN3ME2wMlA4OTR|IN88US=> NYew[Gs2W0GQR1XS
HEC-1 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWjJR|UxRTBwMEexOlEh|ryP NFzQWZJUSU6JRWK=
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SIMA NH\OWWJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYTJR|UxRTBwN{G3NVkh|ryP MV\TRW5ITVJ?
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SW1417 NH7mOWpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYLScItJUUN3ME2wMlgyOzN7IN88US=> MkPxV2FPT0WU
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NCI-H2227 Ml:wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWOyVnM{UUN3ME2xMlA1QThzIN88US=> NXfucIJ6W0GQR1XS
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Mewo M1fu[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYezbpVSUUN3ME2yMlIzOjZ3IN88US=> M{HRUHNCVkeHUh?=
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MC116 NWHzXFRtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkHYTWM2OD1{LkO2N|k4KM7:TR?= NFPVTFlUSU6JRWK=
DG-75 NH3Ebo5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1HlVGlEPTB;Mj60PFU4PiEQvF2= MUTTRW5ITVJ?
HCC1143 M4r3eGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVrJR|UxRTJwNUC2OVgh|ryP NE[4PYZUSU6JRWK=
FTC-133 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX[zNog3UUN3ME2yMlU{Pjh7IN88US=> Mlm2V2FPT0WU
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HT55 MkT6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn7JTWM2OD1{Lk[yNFE6KM7:TR?= Mnf0V2FPT0WU
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MFM-223 NVn4d2JrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUTJR|UxRTNwM{[wPVch|ryP M4XR[XNCVkeHUh?=
TE-5 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHrWRolKSzVyPUSuOVYyPDdizszN NUnUVWZHW0GQR1XS
NCI-H209 M1zocGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M17XVmlEPTB;ND63PFU4OiEQvF2= MnLiV2FPT0WU
SiHa NW\pZoU4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHi1PFFKSzVyPUSuPVUzODNizszN NV\4O5FbW0GQR1XS
NCI-H1395 NW\Bd2R5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIfK[XlKSzVyPUWuNVA3OzNizszN M1jjNnNCVkeHUh?=
A498 Ml7oS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHTtOI9KSzVyPUWuNlEzPTFizszN NUGzd4xkW0GQR1XS
ES5 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnLTTWM2OD13Lk[xNVc5KM7:TR?= M4PYW3NCVkeHUh?=
MDA-MB-157 M{DPWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mme0TWM2OD13Lk[2OFQ{KM7:TR?= MYLTRW5ITVJ?
NCI-H1623 NVLmSY9IT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NE\ycWJKSzVyPUWuPFM2PTZizszN MlHkV2FPT0WU
RPMI-8866 NWjMOnlFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4\wbmlEPTB;NT64OFc6OiEQvF2= MXrTRW5ITVJ?
LC-1F MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEnUOo5KSzVyPU[uNFkzQTFizszN NEGyR21USU6JRWK=
TCCSUP M{nrNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2HSWmlEPTB;Nj62NFM1QSEQvF2= M1H1Z3NCVkeHUh?=
TT MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUTtfo1jUUN3ME24MlM{ODB7IN88US=> NELvUlBUSU6JRWK=
NCI-H1838 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEfLNmZKSzVyPUiuOVE4OzFizszN NVzYfGVsW0GQR1XS
NCI-H322M NXu3e49OT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXLQW5FSUUN3ME25MlE3OjhzIN88US=> MlrjV2FPT0WU
NCI-H187 MlzCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXLJR|UxRTlwNUG4N|Uh|ryP M2PienNCVkeHUh?=
SBC-1 NVPlToJIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXjJR|UxRTlwOUO2OVYh|ryP MWTTRW5ITVJ?
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SW780 NXmzeHNST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYf1TFV1UUN3ME2yNU4yOzF6IN88US=> NH;wNFFUSU6JRWK=
NCI-H345 NG\0RmxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXXWRpRkUUN3ME2yNU45Pzd7IN88US=> M1X0WXNCVkeHUh?=
LB771-HNC MmDSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlvPTWM2OD1{Mj60PFE{KM7:TR?= M1TxOHNCVkeHUh?=
RT4 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlLlTWM2OD1{Mz6zNlgzKM7:TR?= MVTTRW5ITVJ?
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NCI-H524 NYf5[XJNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGnZflhKSzVyPUK0MlM5OTJizszN M{PNeHNCVkeHUh?=
SNU-C1 NHG3N49Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml;ZTWM2OD1{ND65NVA2KM7:TR?= NVW1fYxKW0GQR1XS
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... Click to View More Cell Line Experimental Data

In vivo Treatment with NVP-AUY922 causes a robust antitumor response and inhibits p-Akt and VEGF expression in an HSC-2 xenograft model. [2] In BT474, NVP-AUY922 shows complete loss of ERBB2 and substantial depletion of ERα, in addition to reductions in CDK4 and phospho-ERK1/2. [3]

Protocol

Kinase Assay:[3]
+ Expand

Kinase assay:

NVP-AUY922 is dissolved in DMSO at a concentration of 10 mM. NVP-AUY922 is assessed against HSP90α, HSP90β, GRP94, TRAP-1, HSP72, and topoisomerase II. Profiling against a panel of kinases has been carried out and screening against a panel of additional enzymes and receptors is performed at Cerep.
Cell Research:[1]
+ Expand
  • Cell lines: Human gastric cancer cells NCI-N87
  • Concentrations: 1 μM
  • Incubation Time: 3 days
  • Method: Human gastric cancer cells NCI-N87 (5-7 ×103 in 50 μL/well) are seeded in 96-well plates and incubated at 37 °C for 24 hours, followed by NVP-AUY922 treatment for 1-3 days at 37 °C. After treatment, the cells are assayed by MTT method and analyzed by microplate reader.
    (Only for Reference)
Animal Research:[3]
+ Expand
  • Animal Models: Female NCr athymic mice bearing WM266.4 human melanoma xenografts
  • Formulation: In DMSO and diluted in sterile saline/Tween 20
  • Dosages: 50 mg/kg
  • Administration: Administered via i.v. or i.p.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 93 mg/mL warmed (199.76 mM)
Ethanol 31 mg/mL (66.58 mM)
Water Insoluble
In vivo Add solvents individually and in order:
1% DMSO+30% polyethylene glycol+1% Tween 80
30 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 465.54
Formula

C26H31N3O5

CAS No. 747412-49-3
Storage powder
in solvent
Synonyms VER-52296

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

  • Mass
    Concentration
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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT01784640 Active, not recruiting Recurrent Non-small Cell Lung Cancer|Squamous Cell Lung Cancer|Stage IV Non-small Cell Lung Cancer Jonsson Comprehensive Cancer Center|National Cancer Institute (NCI) January 2014 Phase 1
NCT01922583 Active, not recruiting Non-small Cell Lung Cancer (NSCLC) National Taiwan University Hospital January 2014 Phase 2
NCT01854034 Active, not recruiting Non Small Cell Lung Cancer Massachusetts General Hospital July 2013 Phase 2
NCT01772797 Completed Anaplastic Lymphoma Kinase (ALK)|Non-small Cell Lung Cancer Novartis Pharmaceuticals|Novartis June 2013 Phase 1
NCT01752400 Active, not recruiting Non Small Cell Lung Cancer Massachusetts General Hospital January 2013 Phase 2
NCT01613950 Completed Stomach Neoplasms Esophageal Neoplasms Metastatic Gastric Cancer Mutated PI3KCA Protein Overexpressed HER2 Protein Novartis Pharmaceuticals|Novartis December 2012 Phase 1

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

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HSP (e.g. HSP90) Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID