Luminespib (NVP-AUY922)

Synonyms: AUY-922, VER-52296

Luminespib (AUY-922, NVP-AUY922, VER-52296) is a highly potent HSP90 inhibitor for HSP90α/β with IC50 of 13 nM /21 nM in cell-free assays, weaker potency against the HSP90 family members GRP94 and TRAP-1, exhibits the tightest binding of any small-molecule HSP90 ligand. Luminespib (AUY-922, NVP-AUY922) effectively downregulates and destabilizes the IGF-1Rβ protein and results in growth inhibition, autophagy and apoptosis. Phase 2.

Luminespib (NVP-AUY922) Chemical Structure

Luminespib (NVP-AUY922) Chemical Structure

CAS No. 747412-49-3

Purity & Quality Control

Luminespib (NVP-AUY922) Related Products

Cell Data

Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
NCI-SNU-16 Growth Inhibition Assay IC50=48.3142 μM SANGER
SNU-C1 Growth Inhibition Assay IC50=24.9105 μM SANGER
NCI-H524 Growth Inhibition Assay IC50=24.3812 μM SANGER
NCI-H82 Growth Inhibition Assay IC50=23.5526 μM SANGER
RT4 Growth Inhibition Assay IC50=23.3282 μM SANGER
LB771-HNC Growth Inhibition Assay IC50=22.4813 μM SANGER
SW780 Growth Inhibition Assay IC50=21.1318 μM SANGER
NCI-H345 Growth Inhibition Assay IC50=21.8779 μM SANGER
NCI-H1563 Growth Inhibition Assay IC50=19.7888 μM SANGER
DV-90 Growth Inhibition Assay IC50=18.9945 μM SANGER
Hs-578-T Growth Inhibition Assay IC50=18.5759 μM SANGER
NCI-H2452 Growth Inhibition Assay IC50=14.73 μM SANGER
TGBC24TKB Growth Inhibition Assay IC50=13.529 μM SANGER
SW948 Growth Inhibition Assay IC50=10.7511 μM SANGER
CPC-N Growth Inhibition Assay IC50=11.007 μM SANGER
SCC-3 Growth Inhibition Assay IC50=10.5679 μM SANGER
SBC-1 Growth Inhibition Assay IC50=9.93656 μM SANGER
NCI-H187 Growth Inhibition Assay IC50=9.51835 μM SANGER
NCI-H1838 Growth Inhibition Assay IC50=8.51731 μM SANGER
NCI-H322M Growth Inhibition Assay IC50=9.16281 μM SANGER
TT Growth Inhibition Assay IC50=8.33009 μM SANGER
TCCSUP Growth Inhibition Assay IC50=6.60349 μM SANGER
LC-1F Growth Inhibition Assay IC50=6.09291 μM SANGER
RPMI-8866 Growth Inhibition Assay IC50=5.84792 μM SANGER
NCI-H1623 Growth Inhibition Assay IC50=5.83556 μM SANGER
MDA-MB-157 Growth Inhibition Assay IC50=5.66443 μM SANGER
ES5 Growth Inhibition Assay IC50=5.61178 μM SANGER
A498 Growth Inhibition Assay IC50=5.21251 μM SANGER
NCI-H1395 Growth Inhibition Assay IC50=5.10633 μM SANGER
SiHa Growth Inhibition Assay IC50=4.95203 μM SANGER
NCI-H209 Growth Inhibition Assay IC50=4.78572 μM SANGER
TE-5 Growth Inhibition Assay IC50=4.56147 μM SANGER
MFM-223 Growth Inhibition Assay IC50=3.36097 μM SANGER
COLO-800 Growth Inhibition Assay IC50=3.33897 μM SANGER
D-283MED Growth Inhibition Assay IC50=3.18937 μM SANGER
HCC1395 Growth Inhibition Assay IC50=2.98602 μM SANGER
P12-ICHIKAWA Growth Inhibition Assay IC50=2.82046 μM SANGER
HT55 Growth Inhibition Assay IC50=2.62019 μM SANGER
UMC-11 Growth Inhibition Assay IC50=2.78715 μM SANGER
AsPC-1 Growth Inhibition Assay IC50=2.53929 μM SANGER
NCI-H889 Growth Inhibition Assay IC50=2.56706 μM SANGER
HCC1143 Growth Inhibition Assay IC50=2.50658 μM SANGER
FTC-133 Growth Inhibition Assay IC50=2.53689 μM SANGER
DG-75 Growth Inhibition Assay IC50=2.48576 μM SANGER
MC116 Growth Inhibition Assay IC50=2.36397 μM SANGER
CAL-54 Growth Inhibition Assay IC50=2.26795 μM SANGER
NCI-H720 Growth Inhibition Assay IC50=2.26585 μM SANGER
EM-2 Growth Inhibition Assay IC50=2.20293 μM SANGER
Mewo Growth Inhibition Assay IC50=2.22265 μM SANGER
SK-MEL-28 Growth Inhibition Assay IC50=2.18098 μM SANGER
JAR Growth Inhibition Assay IC50=2.0792 μM SANGER
Caov-3 Growth Inhibition Assay IC50=2.00625 μM SANGER
HuO-3N1 Growth Inhibition Assay IC50=1.83412 μM SANGER
NCI-H1793 Growth Inhibition Assay IC50=1.87593 μM SANGER
HCC1187 Growth Inhibition Assay IC50=1.55522 μM SANGER
EoL-1-cell Growth Inhibition Assay IC50=1.58889 μM SANGER
NCI-H748 Growth Inhibition Assay IC50=1.35738 μM SANGER
NCI-H1581 Growth Inhibition Assay IC50=1.35687 μM SANGER
RO82-W-1 Growth Inhibition Assay IC50=1.33339 μM SANGER
TALL-1 Growth Inhibition Assay IC50=1.25165 μM SANGER
SK-MEL-1 Growth Inhibition Assay IC50=1.20595 μM SANGER
SW1463 Growth Inhibition Assay IC50=1.18349 μM SANGER
NCI-H64 Growth Inhibition Assay IC50=1.1542 μM SANGER
P31-FUJ Growth Inhibition Assay IC50=1.10766 μM SANGER
LP-1 Growth Inhibition Assay IC50=1.0693 μM SANGER
NCI-H2227 Growth Inhibition Assay IC50=1.04981 μM SANGER
HAL-01 Growth Inhibition Assay IC50=0.99379 μM SANGER
NCI-H1993 Growth Inhibition Assay IC50=1.04657 μM SANGER
HT-3 Growth Inhibition Assay IC50=0.8942 μM SANGER
MDA-MB-453 Growth Inhibition Assay IC50=0.90304 μM SANGER
ATN-1 Growth Inhibition Assay IC50=0.85115 μM SANGER
PLC-PRF-5 Growth Inhibition Assay IC50=0.88475 μM SANGER
SW1417 Growth Inhibition Assay IC50=0.81339 μM SANGER
SNU-475 Growth Inhibition Assay IC50=0.79202 μM SANGER
SF539 Growth Inhibition Assay IC50=0.79925 μM SANGER
EC-GI-10 Growth Inhibition Assay IC50=0.77975 μM SANGER
KNS-42 Growth Inhibition Assay IC50=0.78831 μM SANGER
DMS-79 Growth Inhibition Assay IC50=0.77845 μM SANGER
SCLC-21H Growth Inhibition Assay IC50=0.76903 μM SANGER
NCI-H1155 Growth Inhibition Assay IC50=0.74868 μM SANGER
RCC10RGB Growth Inhibition Assay IC50=0.71918 μM SANGER
LN-405 Growth Inhibition Assay IC50=0.7436 μM SANGER
SIMA Growth Inhibition Assay IC50=0.71719 μM SANGER
KY821 Growth Inhibition Assay IC50=0.70229 μM SANGER
TYK-nu Growth Inhibition Assay IC50=0.67952 μM SANGER
NB6 Growth Inhibition Assay IC50=0.67335 μM SANGER
WM-115 Growth Inhibition Assay IC50=0.65092 μM SANGER
HCC1954 Growth Inhibition Assay IC50=0.64726 μM SANGER
NCI-H2126 Growth Inhibition Assay IC50=0.63152 μM SANGER
IST-SL1 Growth Inhibition Assay IC50=0.60435 μM SANGER
C32 Growth Inhibition Assay IC50=0.57313 μM SANGER
KG-1 Growth Inhibition Assay IC50=0.55984 μM SANGER
YAPC Growth Inhibition Assay IC50=0.55211 μM SANGER
JVM-3 Growth Inhibition Assay IC50=0.54117 μM SANGER
RPMI-8402 Growth Inhibition Assay IC50=0.52207 μM SANGER
SW1088 Growth Inhibition Assay IC50=0.53869 μM SANGER
LU-139 Growth Inhibition Assay IC50=0.51457 μM SANGER
CaR-1 Growth Inhibition Assay IC50=0.50367 μM SANGER
D-502MG Growth Inhibition Assay IC50=0.4803 μM SANGER
UACC-812 Growth Inhibition Assay IC50=0.46776 μM SANGER
NEC8 Growth Inhibition Assay IC50=0.45145 μM SANGER
NCI-H716 Growth Inhibition Assay IC50=0.44848 μM SANGER
MHH-CALL-2 Growth Inhibition Assay IC50=0.4483 μM SANGER
T47D Growth Inhibition Assay IC50=0.44528 μM SANGER
JVM-2 Growth Inhibition Assay IC50=0.44401 μM SANGER
NCI-H1882 Growth Inhibition Assay IC50=0.41784 μM SANGER
HPAF-II Growth Inhibition Assay IC50=0.41117 μM SANGER
IST-MES1 Growth Inhibition Assay IC50=0.411 μM SANGER
LB2518-MEL Growth Inhibition Assay IC50=0.40872 μM SANGER
RMG-I Growth Inhibition Assay IC50=0.36691 μM SANGER
SK-N-FI Growth Inhibition Assay IC50=0.37637 μM SANGER
DMS-114 Growth Inhibition Assay IC50=0.3612 μM SANGER
MFE-280 Growth Inhibition Assay IC50=0.35715 μM SANGER
NCI-H719 Growth Inhibition Assay IC50=0.35124 μM SANGER
A704 Growth Inhibition Assay IC50=0.34923 μM SANGER
COLO-829 Growth Inhibition Assay IC50=0.34452 μM SANGER
COLO-678 Growth Inhibition Assay IC50=0.33389 μM SANGER
EFM-19 Growth Inhibition Assay IC50=0.33132 μM SANGER
MDA-MB-175-VII Growth Inhibition Assay IC50=0.32348 μM SANGER
KP-N-YN Growth Inhibition Assay IC50=0.31118 μM SANGER
BT-20 Growth Inhibition Assay IC50=0.31099 μM SANGER
OPM-2 Growth Inhibition Assay IC50=0.31064 μM SANGER
MKN7 Growth Inhibition Assay IC50=0.30639 μM SANGER
NCI-H446 Growth Inhibition Assay IC50=0.29921 μM SANGER
L-540 Growth Inhibition Assay IC50=0.30089 μM SANGER
NCI-H28 Growth Inhibition Assay IC50=0.29837 μM SANGER
Mo-T Growth Inhibition Assay IC50=0.29331 μM SANGER
LB373-MEL-D Growth Inhibition Assay IC50=0.29431 μM SANGER
EW-24 Growth Inhibition Assay IC50=0.2881 μM SANGER
NCI-H510A Growth Inhibition Assay IC50=0.29304 μM SANGER
SW684 Growth Inhibition Assay IC50=0.28383 μM SANGER
RL Growth Inhibition Assay IC50=0.28174 μM SANGER
NCI-H1694 Growth Inhibition Assay IC50=0.27733 μM SANGER
NCI-SNU-5 Growth Inhibition Assay IC50=0.27613 μM SANGER
NCI-H1618 Growth Inhibition Assay IC50=0.2751 μM SANGER
BE-13 Growth Inhibition Assay IC50=0.27249 μM SANGER
SK-N-AS Growth Inhibition Assay IC50=0.2722 μM SANGER
NCI-H69 Growth Inhibition Assay IC50=0.27201 μM SANGER
P30-OHK Growth Inhibition Assay IC50=0.26905 μM SANGER
OAW-28 Growth Inhibition Assay IC50=0.26677 μM SANGER
Raji Growth Inhibition Assay IC50=0.26603 μM SANGER
DOK Growth Inhibition Assay IC50=0.2593 μM SANGER
MHH-NB-11 Growth Inhibition Assay IC50=0.2535 μM SANGER
CAKI-1 Growth Inhibition Assay IC50=0.25086 μM SANGER
SN12C Growth Inhibition Assay IC50=0.24694 μM SANGER
TE-6 Growth Inhibition Assay IC50=0.24612 μM SANGER
EFE-184 Growth Inhibition Assay IC50=0.24597 μM SANGER
CAL-148 Growth Inhibition Assay IC50=0.24282 μM SANGER
MN-60 Growth Inhibition Assay IC50=0.24239 μM SANGER
NCI-H23 Growth Inhibition Assay IC50=0.24059 μM SANGER
LB647-SCLC Growth Inhibition Assay IC50=0.24014 μM SANGER
NB10 Growth Inhibition Assay IC50=0.23731 μM SANGER
NCI-H2141 Growth Inhibition Assay IC50=0.23841 μM SANGER
NCI-H838 Growth Inhibition Assay IC50=0.23714 μM SANGER
IM-9 Growth Inhibition Assay IC50=0.23476 μM SANGER
DB Growth Inhibition Assay IC50=0.22865 μM SANGER
KARPAS-299 Growth Inhibition Assay IC50=0.22994 μM SANGER
A3-KAW Growth Inhibition Assay IC50=0.22708 μM SANGER
EB-3 Growth Inhibition Assay IC50=0.22376 μM SANGER
HT Growth Inhibition Assay IC50=0.22566 μM SANGER
NCI-H1436 Growth Inhibition Assay IC50=0.21826 μM SANGER
NCI-H2196 Growth Inhibition Assay IC50=0.21747 μM SANGER
M14 Growth Inhibition Assay IC50=0.21803 μM SANGER
TGBC1TKB Growth Inhibition Assay IC50=0.20997 μM SANGER
LU-65 Growth Inhibition Assay IC50=0.20211 μM SANGER
MKN45 Growth Inhibition Assay IC50=0.2064 μM SANGER
TE-11 Growth Inhibition Assay IC50=0.19975 μM SANGER
ECC4 Growth Inhibition Assay IC50=0.19863 μM SANGER
C2BBe1 Growth Inhibition Assay IC50=0.19893 μM SANGER
MDA-MB-415 Growth Inhibition Assay IC50=0.19748 μM SANGER
NCI-H2171 Growth Inhibition Assay IC50=0.18649 μM SANGER
NCI-H526 Growth Inhibition Assay IC50=0.18696 μM SANGER
DOHH-2 Growth Inhibition Assay IC50=0.18569 μM SANGER
MS-1 Growth Inhibition Assay IC50=0.186 μM SANGER
COLO-320-HSR Growth Inhibition Assay IC50=0.18493 μM SANGER
EGI-1 Growth Inhibition Assay IC50=0.1797 μM SANGER
SKG-IIIa Growth Inhibition Assay IC50=0.17807 μM SANGER
SK-N-DZ Growth Inhibition Assay IC50=0.17883 μM SANGER
NCI-H1573 Growth Inhibition Assay IC50=0.17678 μM SANGER
EW-3 Growth Inhibition Assay IC50=0.17486 μM SANGER
NCI-H596 Growth Inhibition Assay IC50=0.1738 μM SANGER
MEG-01 Growth Inhibition Assay IC50=0.17257 μM SANGER
MDA-MB-134-VI Growth Inhibition Assay IC50=0.17367 μM SANGER
GOTO Growth Inhibition Assay IC50=0.17246 μM SANGER
HSC-4 Growth Inhibition Assay IC50=0.1716 μM SANGER
K052 Growth Inhibition Assay IC50=0.17061 μM SANGER
COR-L88 Growth Inhibition Assay IC50=0.17114 μM SANGER
CAL-72 Growth Inhibition Assay IC50=0.1659 μM SANGER
TGW Growth Inhibition Assay IC50=0.16471 μM SANGER
KLE Growth Inhibition Assay IC50=0.16169 μM SANGER
NCI-H2170 Growth Inhibition Assay IC50=0.16304 μM SANGER
SK-NEP-1 Growth Inhibition Assay IC50=0.15899 μM SANGER
COR-L279 Growth Inhibition Assay IC50=0.15836 μM SANGER
LU-165 Growth Inhibition Assay IC50=0.15413 μM SANGER
RCM-1 Growth Inhibition Assay IC50=0.1568 μM SANGER
THP-1 Growth Inhibition Assay IC50=0.15333 μM SANGER
NCI-H2081 Growth Inhibition Assay IC50=0.15218 μM SANGER
647-V Growth Inhibition Assay IC50=0.14942 μM SANGER
HCT-116 Growth Inhibition Assay IC50=0.15169 μM SANGER
NCI-H1522 Growth Inhibition Assay IC50=0.14787 μM SANGER
U-266 Growth Inhibition Assay IC50=0.1448 μM SANGER
GI-1 Growth Inhibition Assay IC50=0.14772 μM SANGER
SHP-77 Growth Inhibition Assay IC50=0.14472 μM SANGER
HD-MY-Z Growth Inhibition Assay IC50=0.14429 μM SANGER
NB1 Growth Inhibition Assay IC50=0.14426 μM SANGER
HH Growth Inhibition Assay IC50=0.14201 μM SANGER
NCI-H1092 Growth Inhibition Assay IC50=0.14101 μM SANGER
OVCAR-3 Growth Inhibition Assay IC50=0.14078 μM SANGER
KARPAS-422 Growth Inhibition Assay IC50=0.14037 μM SANGER
NCI-H1755 Growth Inhibition Assay IC50=0.13827 μM SANGER
D-542MG Growth Inhibition Assay IC50=0.13965 μM SANGER
CTB-1 Growth Inhibition Assay IC50=0.13469 μM SANGER
SCC-25 Growth Inhibition Assay IC50=0.13588 μM SANGER
GMS-10 Growth Inhibition Assay IC50=0.13444 μM SANGER
RERF-LC-MS Growth Inhibition Assay IC50=0.1343 μM SANGER
KMS-12-PE Growth Inhibition Assay IC50=0.12869 μM SANGER
PC-3 Growth Inhibition Assay IC50=0.13177 μM SANGER
ChaGo-K-1 Growth Inhibition Assay IC50=0.12699 μM SANGER
S-117 Growth Inhibition Assay IC50=0.12674 μM SANGER
DMS-53 Growth Inhibition Assay IC50=0.12276 μM SANGER
SK-MEL-2 Growth Inhibition Assay IC50=0.1246 μM SANGER
C-4-II Growth Inhibition Assay IC50=0.1217 μM SANGER
UACC-62 Growth Inhibition Assay IC50=0.1212 μM SANGER
CAS-1 Growth Inhibition Assay IC50=0.11964 μM SANGER
AU565 Growth Inhibition Assay IC50=0.11831 μM SANGER
RPMI-8226 Growth Inhibition Assay IC50=0.11719 μM SANGER
LC4-1 Growth Inhibition Assay IC50=0.11466 μM SANGER
BEN Growth Inhibition Assay IC50=0.11607 μM SANGER
NCI-H661 Growth Inhibition Assay IC50=0.11195 μM SANGER
DEL Growth Inhibition Assay IC50=0.11192 μM SANGER
HCC1806 Growth Inhibition Assay IC50=0.11108 μM SANGER
SK-MM-2 Growth Inhibition Assay IC50=0.11145 μM SANGER
NCI-H441 Growth Inhibition Assay IC50=0.10899 μM SANGER
COLO-824 Growth Inhibition Assay IC50=0.1102 μM SANGER
KU-19-19 Growth Inhibition Assay IC50=0.10817 μM SANGER
EW-18 Growth Inhibition Assay IC50=0.10604 μM SANGER
EKVX Growth Inhibition Assay IC50=0.10483 μM SANGER
23132-87 Growth Inhibition Assay IC50=0.10488 μM SANGER
A673 Growth Inhibition Assay IC50=0.10431 μM SANGER
NCI-H2052 Growth Inhibition Assay IC50=0.10407 μM SANGER
GR-ST Growth Inhibition Assay IC50=0.1021 μM SANGER
PFSK-1 Growth Inhibition Assay IC50=0.10267 μM SANGER
LK-2 Growth Inhibition Assay IC50=0.10176 μM SANGER
HCC2218 Growth Inhibition Assay IC50=0.09999 μM SANGER
HT-1376 Growth Inhibition Assay IC50=0.09861 μM SANGER
MDA-MB-468 Growth Inhibition Assay IC50=0.09985 μM SANGER
MPP-89 Growth Inhibition Assay IC50=0.09721 μM SANGER
IPC-298 Growth Inhibition Assay IC50=0.09644 μM SANGER
HCC1599 Growth Inhibition Assay IC50=0.09601 μM SANGER
HCC1419 Growth Inhibition Assay IC50=0.09541 μM SANGER
JEG-3 Growth Inhibition Assay IC50=0.09505 μM SANGER
NB12 Growth Inhibition Assay IC50=0.09518 μM SANGER
SJRH30 Growth Inhibition Assay IC50=0.09444 μM SANGER
KARPAS-45 Growth Inhibition Assay IC50=0.09345 μM SANGER
EVSA-T Growth Inhibition Assay IC50=0.09265 μM SANGER
MHH-PREB-1 Growth Inhibition Assay IC50=0.0931 μM SANGER
SNU-387 Growth Inhibition Assay IC50=0.09218 μM SANGER
SBC-5 Growth Inhibition Assay IC50=0.09193 μM SANGER
SAS Growth Inhibition Assay IC50=0.09215 μM SANGER
MDA-MB-231 Growth Inhibition Assay IC50=0.09082 μM SANGER
EFO-21 Growth Inhibition Assay IC50=0.08991 μM SANGER
J-RT3-T3-5 Growth Inhibition Assay IC50=0.08968 μM SANGER
COLO-792 Growth Inhibition Assay IC50=0.08855 μM SANGER
ES3 Growth Inhibition Assay IC50=0.08763 μM SANGER
LAN-6 Growth Inhibition Assay IC50=0.08498 μM SANGER
ABC-1 Growth Inhibition Assay IC50=0.08759 μM SANGER
CP50-MEL-B Growth Inhibition Assay IC50=0.08368 μM SANGER
KP-N-YS Growth Inhibition Assay IC50=0.08345 μM SANGER
NCI-H1304 Growth Inhibition Assay IC50=0.08271 μM SANGER
COLO-684 Growth Inhibition Assay IC50=0.08158 μM SANGER
LNCaP-Clone-FGC Growth Inhibition Assay IC50=0.08165 μM SANGER
NCI-H2347 Growth Inhibition Assay IC50=0.08028 μM SANGER
CAL-27 Growth Inhibition Assay IC50=0.08156 μM SANGER
COLO-668 Growth Inhibition Assay IC50=0.07984 μM SANGER
SK-CO-1 Growth Inhibition Assay IC50=0.07992 μM SANGER
MV-4-11 Growth Inhibition Assay IC50=0.000558 μM SANGER
CMK Growth Inhibition Assay IC50=0.000125 μM SANGER
HOS Growth Inhibition Assay IC50=0.00138 μM SANGER
NALM-6 Growth Inhibition Assay IC50=0.000842 μM SANGER
TE-8 Growth Inhibition Assay IC50=0.00237 μM SANGER
SW1710 Growth Inhibition Assay IC50=0.00186 μM SANGER
HT-144 Growth Inhibition Assay IC50=0.00155 μM SANGER
PSN1 Growth Inhibition Assay IC50=0.00318 μM SANGER
CCF-STTG1 Growth Inhibition Assay IC50=0.00297 μM SANGER
ES1 Growth Inhibition Assay IC50=0.00266 μM SANGER
CAL-51 Growth Inhibition Assay IC50=0.00325 μM SANGER
MCF7 Growth Inhibition Assay IC50=0.00335 μM SANGER
HMV-II Growth Inhibition Assay IC50=0.00449 μM SANGER
LCLC-103H Growth Inhibition Assay IC50=0.0043 μM SANGER
SK-HEP-1 Growth Inhibition Assay IC50=0.00336 μM SANGER
MES-SA Growth Inhibition Assay IC50=0.00452 μM SANGER
SIG-M5 Growth Inhibition Assay IC50=0.00489 μM SANGER
639-V Growth Inhibition Assay IC50=0.00485 μM SANGER
SK-LMS-1 Growth Inhibition Assay IC50=0.00458 μM SANGER
HSC-2 Growth Inhibition Assay IC50=0.00518 μM SANGER
LOUCY Growth Inhibition Assay IC50=0.00505 μM SANGER
RT-112 Growth Inhibition Assay IC50=0.00535 μM SANGER
EW-13 Growth Inhibition Assay IC50=0.00518 μM SANGER
KYSE-180 Growth Inhibition Assay IC50=0.00586 μM SANGER
NKM-1 Growth Inhibition Assay IC50=0.00547 μM SANGER
A431 Growth Inhibition Assay IC50=0.00607 μM SANGER
SW1783 Growth Inhibition Assay IC50=0.00591 μM SANGER
RPMI-7951 Growth Inhibition Assay IC50=0.00631 μM SANGER
SK-OV-3 Growth Inhibition Assay IC50=0.0063 μM SANGER
HSC-3 Growth Inhibition Assay IC50=0.00641 μM SANGER
Capan-2 Growth Inhibition Assay IC50=0.00638 μM SANGER
Daoy Growth Inhibition Assay IC50=0.00695 μM SANGER
786-0 Growth Inhibition Assay IC50=0.00663 μM SANGER
EW-16 Growth Inhibition Assay IC50=0.00749 μM SANGER
KGN Growth Inhibition Assay IC50=0.00703 μM SANGER
IGROV-1 Growth Inhibition Assay IC50=0.00814 μM SANGER
EW-7 Growth Inhibition Assay IC50=0.00754 μM SANGER
8505C Growth Inhibition Assay IC50=0.00821 μM SANGER
IST-MEL1 Growth Inhibition Assay IC50=0.00852 μM SANGER
GDM-1 Growth Inhibition Assay IC50=0.0084 μM SANGER
RKO Growth Inhibition Assay IC50=0.00826 μM SANGER
RPMI-6666 Growth Inhibition Assay IC50=0.00852 μM SANGER
SNG-M Growth Inhibition Assay IC50=0.00856 μM SANGER
RXF393 Growth Inhibition Assay IC50=0.0086 μM SANGER
KS-1 Growth Inhibition Assay IC50=0.00859 μM SANGER
BFTC-905 Growth Inhibition Assay IC50=0.00938 μM SANGER
CAL-12T Growth Inhibition Assay IC50=0.00922 μM SANGER
SK-MES-1 Growth Inhibition Assay IC50=0.00945 μM SANGER
AN3-CA Growth Inhibition Assay IC50=0.01017 μM SANGER
BB30-HNC Growth Inhibition Assay IC50=0.00952 μM SANGER
G-401 Growth Inhibition Assay IC50=0.01025 μM SANGER
EFO-27 Growth Inhibition Assay IC50=0.01017 μM SANGER
NCI-H727 Growth Inhibition Assay IC50=0.0103 μM SANGER
BPH-1 Growth Inhibition Assay IC50=0.0103 μM SANGER
KYSE-270 Growth Inhibition Assay IC50=0.01059 μM SANGER
SNU-423 Growth Inhibition Assay IC50=0.01053 μM SANGER
NCI-H2228 Growth Inhibition Assay IC50=0.01064 μM SANGER
AGS Growth Inhibition Assay IC50=0.01061 μM SANGER
SW954 Growth Inhibition Assay IC50=0.01071 μM SANGER
IA-LM Growth Inhibition Assay IC50=0.01086 μM SANGER
BB49-HNC Growth Inhibition Assay IC50=0.01077 μM SANGER
769-P Growth Inhibition Assay IC50=0.01073 μM SANGER
NB69 Growth Inhibition Assay IC50=0.01102 μM SANGER
C8166 Growth Inhibition Assay IC50=0.01129 μM SANGER
YKG-1 Growth Inhibition Assay IC50=0.0116 μM SANGER
NCI-H1299 Growth Inhibition Assay IC50=0.01154 μM SANGER
YT Growth Inhibition Assay IC50=0.01179 μM SANGER
PANC-03-27 Growth Inhibition Assay IC50=0.01162 μM SANGER
GT3TKB Growth Inhibition Assay IC50=0.01202 μM SANGER
CAL-85-1 Growth Inhibition Assay IC50=0.01192 μM SANGER
ES6 Growth Inhibition Assay IC50=0.01261 μM SANGER
BB65-RCC Growth Inhibition Assay IC50=0.01204 μM SANGER
MHH-ES-1 Growth Inhibition Assay IC50=0.01263 μM SANGER
OCI-AML2 Growth Inhibition Assay IC50=0.01281 μM SANGER
SNU-C2B Growth Inhibition Assay IC50=0.01272 μM SANGER
QIMR-WIL Growth Inhibition Assay IC50=0.01269 μM SANGER
SW982 Growth Inhibition Assay IC50=0.01293 μM SANGER
DU-145 Growth Inhibition Assay IC50=0.0129 μM SANGER
MFH-ino Growth Inhibition Assay IC50=0.01293 μM SANGER
A427 Growth Inhibition Assay IC50=0.01299 μM SANGER
K5 Growth Inhibition Assay IC50=0.01308 μM SANGER
AM-38 Growth Inhibition Assay IC50=0.01302 μM SANGER
LCLC-97TM1 Growth Inhibition Assay IC50=0.013 μM SANGER
TE-15 Growth Inhibition Assay IC50=0.01336 μM SANGER
T84 Growth Inhibition Assay IC50=0.01331 μM SANGER
NCI-H460 Growth Inhibition Assay IC50=0.01336 μM SANGER
NTERA-S-cl-D1 Growth Inhibition Assay IC50=0.01339 μM SANGER
H4 Growth Inhibition Assay IC50=0.01366 μM SANGER
KYSE-450 Growth Inhibition Assay IC50=0.01349 μM SANGER
GAMG Growth Inhibition Assay IC50=0.01371 μM SANGER
LC-2-ad Growth Inhibition Assay IC50=0.0137 μM SANGER
NCI-H2122 Growth Inhibition Assay IC50=0.01384 μM SANGER
TK10 Growth Inhibition Assay IC50=0.01382 μM SANGER
KM12 Growth Inhibition Assay IC50=0.01399 μM SANGER
KYSE-510 Growth Inhibition Assay IC50=0.01442 μM SANGER
RPMI-2650 Growth Inhibition Assay IC50=0.01432 μM SANGER
CAL-39 Growth Inhibition Assay IC50=0.0142 μM SANGER
KALS-1 Growth Inhibition Assay IC50=0.01466 μM SANGER
NCI-H1648 Growth Inhibition Assay IC50=0.01499 μM SANGER
ES4 Growth Inhibition Assay IC50=0.01502 μM SANGER
C-33-A Growth Inhibition Assay IC50=0.01509 μM SANGER
HOP-62 Growth Inhibition Assay IC50=0.01542 μM SANGER
Becker Growth Inhibition Assay IC50=0.01514 μM SANGER
MIA-PaCa-2 Growth Inhibition Assay IC50=0.01509 μM SANGER
KYSE-410 Growth Inhibition Assay IC50=0.01586 μM SANGER
TE-1 Growth Inhibition Assay IC50=0.01581 μM SANGER
MEL-HO Growth Inhibition Assay IC50=0.01643 μM SANGER
NOS-1 Growth Inhibition Assay IC50=0.01593 μM SANGER
NCI-H1650 Growth Inhibition Assay IC50=0.01646 μM SANGER
ACN Growth Inhibition Assay IC50=0.01657 μM SANGER
HuP-T3 Growth Inhibition Assay IC50=0.01653 μM SANGER
VMRC-RCZ Growth Inhibition Assay IC50=0.01651 μM SANGER
HT-1197 Growth Inhibition Assay IC50=0.01685 μM SANGER
MEL-JUSO Growth Inhibition Assay IC50=0.01681 μM SANGER
A4-Fuk Growth Inhibition Assay IC50=0.01702 μM SANGER
NCI-H2030 Growth Inhibition Assay IC50=0.01697 μM SANGER
A2780 Growth Inhibition Assay IC50=0.01715 μM SANGER
NCI-H292 Growth Inhibition Assay IC50=0.01709 μM SANGER
NCI-H810 Growth Inhibition Assay IC50=0.01724 μM SANGER
SF295 Growth Inhibition Assay IC50=0.01721 μM SANGER
ALL-PO Growth Inhibition Assay IC50=0.01735 μM SANGER
NY Growth Inhibition Assay IC50=0.0174 μM SANGER
MC-IXC Growth Inhibition Assay IC50=0.01736 μM SANGER
OMC-1 Growth Inhibition Assay IC50=0.01751 μM SANGER
NCI-H2342 Growth Inhibition Assay IC50=0.01758 μM SANGER
PANC-10-05 Growth Inhibition Assay IC50=0.01755 μM SANGER
TE-12 Growth Inhibition Assay IC50=0.01775 μM SANGER
HGC-27 Growth Inhibition Assay IC50=0.01758 μM SANGER
MOLT-16 Growth Inhibition Assay IC50=0.01788 μM SANGER
OVCAR-5 Growth Inhibition Assay IC50=0.01812 μM SANGER
HL-60 Growth Inhibition Assay IC50=0.01807 μM SANGER
MG-63 Growth Inhibition Assay IC50=0.01874 μM SANGER
SK-LU-1 Growth Inhibition Assay IC50=0.01846 μM SANGER
COR-L105 Growth Inhibition Assay IC50=0.01911 μM SANGER
8-MG-BA Growth Inhibition Assay IC50=0.01884 μM SANGER
SW620 Growth Inhibition Assay IC50=0.01915 μM SANGER
BHY Growth Inhibition Assay IC50=0.01912 μM SANGER
PC-14 Growth Inhibition Assay IC50=0.01934 μM SANGER
NCI-H522 Growth Inhibition Assay IC50=0.01939 μM SANGER
OE19 Growth Inhibition Assay IC50=0.0195 μM SANGER
A101D Growth Inhibition Assay IC50=0.01987 μM SANGER
TE-10 Growth Inhibition Assay IC50=0.01977 μM SANGER
RVH-421 Growth Inhibition Assay IC50=0.01957 μM SANGER
HUTU-80 Growth Inhibition Assay IC50=0.02004 μM SANGER
KYSE-140 Growth Inhibition Assay IC50=0.02024 μM SANGER
SNU-449 Growth Inhibition Assay IC50=0.02026 μM SANGER
697 Growth Inhibition Assay IC50=0.02031 μM SANGER
SJSA-1 Growth Inhibition Assay IC50=0.02037 μM SANGER
IGR-1 Growth Inhibition Assay IC50=0.0205 μM SANGER
GCIY Growth Inhibition Assay IC50=0.02055 μM SANGER
REH Growth Inhibition Assay IC50=0.02059 μM SANGER
A204 Growth Inhibition Assay IC50=0.02115 μM SANGER
NCI-H650 Growth Inhibition Assay IC50=0.02117 μM SANGER
A388 Growth Inhibition Assay IC50=0.02115 μM SANGER
SW626 Growth Inhibition Assay IC50=0.0212 μM SANGER
DoTc2-4510 Growth Inhibition Assay IC50=0.02122 μM SANGER
HCE-4 Growth Inhibition Assay IC50=0.02145 μM SANGER
DU-4475 Growth Inhibition Assay IC50=0.0215 μM SANGER
A375 Growth Inhibition Assay IC50=0.02171 μM SANGER
GB-1 Growth Inhibition Assay IC50=0.02188 μM SANGER
HT-1080 Growth Inhibition Assay IC50=0.02214 μM SANGER
CHP-212 Growth Inhibition Assay IC50=0.02212 μM SANGER
M059J Growth Inhibition Assay IC50=0.02241 μM SANGER
NMC-G1 Growth Inhibition Assay IC50=0.0228 μM SANGER
MFE-296 Growth Inhibition Assay IC50=0.02322 μM SANGER
MRK-nu-1 Growth Inhibition Assay IC50=0.023 μM SANGER
LOXIMVI Growth Inhibition Assay IC50=0.02323 μM SANGER
CGTH-W-1 Growth Inhibition Assay IC50=0.02328 μM SANGER
CCRF-CEM Growth Inhibition Assay IC50=0.02329 μM SANGER
ACHN Growth Inhibition Assay IC50=0.02345 μM SANGER
NCI-H1355 Growth Inhibition Assay IC50=0.02401 μM SANGER
NCI-H1651 Growth Inhibition Assay IC50=0.02431 μM SANGER
KINGS-1 Growth Inhibition Assay IC50=0.02433 μM SANGER
LS-123 Growth Inhibition Assay IC50=0.02435 μM SANGER
SNB75 Growth Inhibition Assay IC50=0.02466 μM SANGER
C3A Growth Inhibition Assay IC50=0.02475 μM SANGER
HO-1-N-1 Growth Inhibition Assay IC50=0.02549 μM SANGER
EHEB Growth Inhibition Assay IC50=0.02555 μM SANGER
CAL-62 Growth Inhibition Assay IC50=0.0257 μM SANGER
U-118-MG Growth Inhibition Assay IC50=0.02576 μM SANGER
HN Growth Inhibition Assay IC50=0.02593 μM SANGER
HTC-C3 Growth Inhibition Assay IC50=0.02607 μM SANGER
KYSE-520 Growth Inhibition Assay IC50=0.02613 μM SANGER
MZ1-PC Growth Inhibition Assay IC50=0.02639 μM SANGER
BCPAP Growth Inhibition Assay IC50=0.02646 μM SANGER
RD Growth Inhibition Assay IC50=0.02658 μM SANGER
LXF-289 Growth Inhibition Assay IC50=0.02668 μM SANGER
NCI-H520 Growth Inhibition Assay IC50=0.02664 μM SANGER
G-361 Growth Inhibition Assay IC50=0.02677 μM SANGER
COR-L23 Growth Inhibition Assay IC50=0.02713 μM SANGER
LB996-RCC Growth Inhibition Assay IC50=0.0271 μM SANGER
GP5d Growth Inhibition Assay IC50=0.02723 μM SANGER
SW1990 Growth Inhibition Assay IC50=0.02724 μM SANGER
PA-1 Growth Inhibition Assay IC50=0.02755 μM SANGER
NCI-H2009 Growth Inhibition Assay IC50=0.0276 μM SANGER
SR Growth Inhibition Assay IC50=0.02785 μM SANGER
Ca9-22 Growth Inhibition Assay IC50=0.02796 μM SANGER
SCC-15 Growth Inhibition Assay IC50=0.02801 μM SANGER
ETK-1 Growth Inhibition Assay IC50=0.02806 μM SANGER
SCC-4 Growth Inhibition Assay IC50=0.02809 μM SANGER
5637 Growth Inhibition Assay IC50=0.02822 μM SANGER
EW-1 Growth Inhibition Assay IC50=0.02822 μM SANGER
SW962 Growth Inhibition Assay IC50=0.02852 μM SANGER
HCE-T Growth Inhibition Assay IC50=0.0286 μM SANGER
NCI-H2405 Growth Inhibition Assay IC50=0.02887 μM SANGER
A2058 Growth Inhibition Assay IC50=0.02929 μM SANGER
HCC2998 Growth Inhibition Assay IC50=0.02945 μM SANGER
ONS-76 Growth Inhibition Assay IC50=0.02954 μM SANGER
DBTRG-05MG Growth Inhibition Assay IC50=0.02955 μM SANGER
HuCCT1 Growth Inhibition Assay IC50=0.02961 μM SANGER
J82 Growth Inhibition Assay IC50=0.03007 μM SANGER
MKN28 Growth Inhibition Assay IC50=0.03012 μM SANGER
SW837 Growth Inhibition Assay IC50=0.03014 μM SANGER
no-10 Growth Inhibition Assay IC50=0.03016 μM SANGER
BC-3 Growth Inhibition Assay IC50=0.03018 μM SANGER
8305C Growth Inhibition Assay IC50=0.03072 μM SANGER
no-11 Growth Inhibition Assay IC50=0.03048 μM SANGER
COLO-679 Growth Inhibition Assay IC50=0.03107 μM SANGER
CESS Growth Inhibition Assay IC50=0.0312 μM SANGER
BFTC-909 Growth Inhibition Assay IC50=0.03125 μM SANGER
MZ2-MEL Growth Inhibition Assay IC50=0.03177 μM SANGER
LB831-BLC Growth Inhibition Assay IC50=0.03219 μM SANGER
SW872 Growth Inhibition Assay IC50=0.03217 μM SANGER
NCI-H1734 Growth Inhibition Assay IC50=0.0323 μM SANGER
SK-UT-1 Growth Inhibition Assay IC50=0.03221 μM SANGER
OVCAR-8 Growth Inhibition Assay IC50=0.03281 μM SANGER
NCI-H2087 Growth Inhibition Assay IC50=0.03289 μM SANGER
U-87-MG Growth Inhibition Assay IC50=0.0329 μM SANGER
BC-1 Growth Inhibition Assay IC50=0.03367 μM SANGER
ES7 Growth Inhibition Assay IC50=0.03374 μM SANGER
RS4-11 Growth Inhibition Assay IC50=0.03383 μM SANGER
Daudi Growth Inhibition Assay IC50=0.03376 μM SANGER
JiyoyeP-2003 Growth Inhibition Assay IC50=0.03388 μM SANGER
OS-RC-2 Growth Inhibition Assay IC50=0.03396 μM SANGER
BL-70 Growth Inhibition Assay IC50=0.03389 μM SANGER
SF268 Growth Inhibition Assay IC50=0.03401 μM SANGER
BV-173 Growth Inhibition Assay IC50=0.03426 μM SANGER
DMS-273 Growth Inhibition Assay IC50=0.03479 μM SANGER
ES8 Growth Inhibition Assay IC50=0.03538 μM SANGER
22RV1 Growth Inhibition Assay IC50=0.03507 μM SANGER
KYSE-150 Growth Inhibition Assay IC50=0.03608 μM SANGER
HCC1569 Growth Inhibition Assay IC50=0.03608 μM SANGER
NB5 Growth Inhibition Assay IC50=0.03613 μM SANGER
G-402 Growth Inhibition Assay IC50=0.03614 μM SANGER
NCI-H1693 Growth Inhibition Assay IC50=0.03617 μM SANGER
LB2241-RCC Growth Inhibition Assay IC50=0.03642 μM SANGER
KP-4 Growth Inhibition Assay IC50=0.03663 μM SANGER
ML-2 Growth Inhibition Assay IC50=0.03671 μM SANGER
KU812 Growth Inhibition Assay IC50=0.03684 μM SANGER
LS-411N Growth Inhibition Assay IC50=0.03731 μM SANGER
OAW-42 Growth Inhibition Assay IC50=0.03747 μM SANGER
HCC38 Growth Inhibition Assay IC50=0.03771 μM SANGER
Calu-3 Growth Inhibition Assay IC50=0.03789 μM SANGER
Ca-Ski Growth Inhibition Assay IC50=0.03784 μM SANGER
KYSE-70 Growth Inhibition Assay IC50=0.03812 μM SANGER
OVCAR-4 Growth Inhibition Assay IC50=0.03858 μM SANGER
D-392MG Growth Inhibition Assay IC50=0.03842 μM SANGER
HEL Growth Inhibition Assay IC50=0.03891 μM SANGER
Detroit562 Growth Inhibition Assay IC50=0.03872 μM SANGER
MONO-MAC-6 Growth Inhibition Assay IC50=0.03893 μM SANGER
LoVo Growth Inhibition Assay IC50=0.03933 μM SANGER
U-2-OS Growth Inhibition Assay IC50=0.03935 μM SANGER
A172 Growth Inhibition Assay IC50=0.0395 μM SANGER
OCUB-M Growth Inhibition Assay IC50=0.03961 μM SANGER
SW48 Growth Inhibition Assay IC50=0.04031 μM SANGER
HC-1 Growth Inhibition Assay IC50=0.04069 μM SANGER
HDLM-2 Growth Inhibition Assay IC50=0.04114 μM SANGER
KOSC-2 Growth Inhibition Assay IC50=0.0411 μM SANGER
CTV-1 Growth Inhibition Assay IC50=0.04116 μM SANGER
SH-4 Growth Inhibition Assay IC50=0.04141 μM SANGER
SW756 Growth Inhibition Assay IC50=0.04157 μM SANGER
GCT Growth Inhibition Assay IC50=0.04161 μM SANGER
CHL-1 Growth Inhibition Assay IC50=0.04169 μM SANGER
LS-1034 Growth Inhibition Assay IC50=0.04191 μM SANGER
LAMA-84 Growth Inhibition Assay IC50=0.04171 μM SANGER
NCI-H358 Growth Inhibition Assay IC50=0.04212 μM SANGER
NB13 Growth Inhibition Assay IC50=0.04227 μM SANGER
TE-9 Growth Inhibition Assay IC50=0.04237 μM SANGER
OE33 Growth Inhibition Assay IC50=0.04241 μM SANGER
CAL-120 Growth Inhibition Assay IC50=0.04241 μM SANGER
DJM-1 Growth Inhibition Assay IC50=0.04272 μM SANGER
VA-ES-BJ Growth Inhibition Assay IC50=0.04292 μM SANGER
SK-MEL-24 Growth Inhibition Assay IC50=0.04283 μM SANGER
MMAC-SF Growth Inhibition Assay IC50=0.04297 μM SANGER
MZ7-mel Growth Inhibition Assay IC50=0.0433 μM SANGER
BxPC-3 Growth Inhibition Assay IC50=0.04341 μM SANGER
HT-29 Growth Inhibition Assay IC50=0.04357 μM SANGER
SK-MEL-30 Growth Inhibition Assay IC50=0.04362 μM SANGER
COLO-680N Growth Inhibition Assay IC50=0.04407 μM SANGER
CAL-33 Growth Inhibition Assay IC50=0.04375 μM SANGER
NH-12 Growth Inhibition Assay IC50=0.0444 μM SANGER
HCC1937 Growth Inhibition Assay IC50=0.04456 μM SANGER
IMR-5 Growth Inhibition Assay IC50=0.0449 μM SANGER
MC-CAR Growth Inhibition Assay IC50=0.04569 μM SANGER
NCI-H747 Growth Inhibition Assay IC50=0.0457 μM SANGER
NCI-H1792 Growth Inhibition Assay IC50=0.04581 μM SANGER
SW13 Growth Inhibition Assay IC50=0.0459 μM SANGER
MLMA Growth Inhibition Assay IC50=0.04609 μM SANGER
U251 Growth Inhibition Assay IC50=0.04763 μM SANGER
U031 Growth Inhibition Assay IC50=0.04771 μM SANGER
ME-180 Growth Inhibition Assay IC50=0.04782 μM SANGER
SK-MEL-3 Growth Inhibition Assay IC50=0.04802 μM SANGER
MOLT-4 Growth Inhibition Assay IC50=0.04803 μM SANGER
NUGC-3 Growth Inhibition Assay IC50=0.04827 μM SANGER
PF-382 Growth Inhibition Assay IC50=0.04826 μM SANGER
NCI-H1417 Growth Inhibition Assay IC50=0.0489 μM SANGER
COLO-205 Growth Inhibition Assay IC50=0.04919 μM SANGER
TE-441-T Growth Inhibition Assay IC50=0.0493 μM SANGER
MKN1 Growth Inhibition Assay IC50=0.0493 μM SANGER
UM-UC-3 Growth Inhibition Assay IC50=0.0495 μM SANGER
SF126 Growth Inhibition Assay IC50=0.0501 μM SANGER
A253 Growth Inhibition Assay IC50=0.05052 μM SANGER
LB1047-RCC Growth Inhibition Assay IC50=0.05031 μM SANGER
NCI-H1963 Growth Inhibition Assay IC50=0.05176 μM SANGER
VM-CUB-1 Growth Inhibition Assay IC50=0.05311 μM SANGER
T-24 Growth Inhibition Assay IC50=0.05384 μM SANGER
K-562 Growth Inhibition Assay IC50=0.05387 μM SANGER
ARH-77 Growth Inhibition Assay IC50=0.05395 μM SANGER
CA46 Growth Inhibition Assay IC50=0.0543 μM SANGER
HCC70 Growth Inhibition Assay IC50=0.05452 μM SANGER
ST486 Growth Inhibition Assay IC50=0.05525 μM SANGER
COLO-741 Growth Inhibition Assay IC50=0.05531 μM SANGER
SK-PN-DW Growth Inhibition Assay IC50=0.05588 μM SANGER
D-263MG Growth Inhibition Assay IC50=0.05683 μM SANGER
BL-41 Growth Inhibition Assay IC50=0.05596 μM SANGER
KE-37 Growth Inhibition Assay IC50=0.05683 μM SANGER
LU-134-A Growth Inhibition Assay IC50=0.05715 μM SANGER
HCC2157 Growth Inhibition Assay IC50=0.05733 μM SANGER
IST-SL2 Growth Inhibition Assay IC50=0.05743 μM SANGER
GAK Growth Inhibition Assay IC50=0.05734 μM SANGER
KMOE-2 Growth Inhibition Assay IC50=0.05749 μM SANGER
SW1573 Growth Inhibition Assay IC50=0.05802 μM SANGER
SCC-9 Growth Inhibition Assay IC50=0.0587 μM SANGER
MDA-MB-361 Growth Inhibition Assay IC50=0.05872 μM SANGER
BHT-101 Growth Inhibition Assay IC50=0.05876 μM SANGER
NCI-H1770 Growth Inhibition Assay IC50=0.05879 μM SANGER
UACC-893 Growth Inhibition Assay IC50=0.05896 μM SANGER
NCI-H226 Growth Inhibition Assay IC50=0.05988 μM SANGER
HLE Growth Inhibition Assay IC50=0.06082 μM SANGER
NCI-H1703 Growth Inhibition Assay IC50=0.06178 μM SANGER
KURAMOCHI Growth Inhibition Assay IC50=0.06189 μM SANGER
RH-1 Growth Inhibition Assay IC50=0.0623 μM SANGER
CAMA-1 Growth Inhibition Assay IC50=0.06303 μM SANGER
DSH1 Growth Inhibition Assay IC50=0.0627 μM SANGER
NCI-H1437 Growth Inhibition Assay IC50=0.06328 μM SANGER
HuP-T4 Growth Inhibition Assay IC50=0.06586 μM SANGER
HCT-15 Growth Inhibition Assay IC50=0.06597 μM SANGER
NCCIT Growth Inhibition Assay IC50=0.06604 μM SANGER
BOKU Growth Inhibition Assay IC50=0.06674 μM SANGER
FADU Growth Inhibition Assay IC50=0.06745 μM SANGER
SUP-T1 Growth Inhibition Assay IC50=0.0676 μM SANGER
L-363 Growth Inhibition Assay IC50=0.06901 μM SANGER
KNS-81-FD Growth Inhibition Assay IC50=0.06918 μM SANGER
SU-DHL-1 Growth Inhibition Assay IC50=0.0692 μM SANGER
HuH-7 Growth Inhibition Assay IC50=0.07035 μM SANGER
CAPAN-1 Growth Inhibition Assay IC50=0.07143 μM SANGER
BT-474 Growth Inhibition Assay IC50=0.07061 μM SANGER
HEC-1 Growth Inhibition Assay IC50=0.07161 μM SANGER
NOMO-1 Growth Inhibition Assay IC50=0.07172 μM SANGER
KM-H2 Growth Inhibition Assay IC50=0.07241 μM SANGER
EB2 Growth Inhibition Assay IC50=0.07285 μM SANGER
LU-99A Growth Inhibition Assay IC50=0.07287 μM SANGER
WSU-NHL Growth Inhibition Assay IC50=0.07329 μM SANGER
Calu-1 Growth Inhibition Assay IC50=0.07332 μM SANGER
U-698-M Growth Inhibition Assay IC50=0.07382 μM SANGER
GI-ME-N Growth Inhibition Assay IC50=0.07426 μM SANGER
T98G Growth Inhibition Assay IC50=0.07421 μM SANGER
LS-513 Growth Inhibition Assay IC50=0.07456 μM SANGER
UACC-257 Growth Inhibition Assay IC50=0.07505 μM SANGER
DK-MG Growth Inhibition Assay IC50=0.07526 μM SANGER
CHP-126 Growth Inhibition Assay IC50=0.07565 μM SANGER
EW-11 Growth Inhibition Assay IC50=0.07535 μM SANGER
Ramos-2G6-4C10 Growth Inhibition Assay IC50=0.07648 μM SANGER
Saos-2 Growth Inhibition Assay IC50=0.07597 μM SANGER
L-428 Growth Inhibition Assay IC50=0.07704 μM SANGER
HOP-92 Growth Inhibition Assay IC50=0.07711 μM SANGER
PANC-08-13 Growth Inhibition Assay IC50=0.07716 μM SANGER
TUR Growth Inhibition Assay IC50=0.07733 μM SANGER
DMS-153 Growth Inhibition Assay IC50=0.07735 μM SANGER
NCI-N87 Growth Inhibition Assay IC50=0.07799 μM SANGER
ESS-1 Growth Inhibition Assay IC50=0.07868 μM SANGER
NCI-SNU-1 Growth Inhibition Assay IC50=0.07888 μM SANGER
CP66-MEL Growth Inhibition Assay IC50=0.07887 μM SANGER
Calu-6 Growth Inhibition Assay IC50=0.07965 μM SANGER
Click to View More Cell Line Experimental Data

Biological Activity

Description Luminespib (AUY-922, NVP-AUY922, VER-52296) is a highly potent HSP90 inhibitor for HSP90α/β with IC50 of 13 nM /21 nM in cell-free assays, weaker potency against the HSP90 family members GRP94 and TRAP-1, exhibits the tightest binding of any small-molecule HSP90 ligand. Luminespib (AUY-922, NVP-AUY922) effectively downregulates and destabilizes the IGF-1Rβ protein and results in growth inhibition, autophagy and apoptosis. Phase 2.
Targets
HSP90α [1]
(Cell-free assay)
HSP90β [1]
(Cell-free assay)
13 nM 21 nM
In vitro
In vitro NVP-AUY922 inhibits proliferation of various human cancer cell lines in vitro, with an average GI50 of 9 nM. [1] The IC50 values of NVP-AUY922 fall in the range of 2 to 40 nM in these gastric cancer cell lines. IC50 value for the BEAS-2B cells is 28.49 nM. Treatment with NVP-AUY922 does not influence the expression of HSP90, but expression of HSP70 gets elevated by NVP-AUY922 treatment. NVP-AUY922 increases the binding of HSP70 to HSP90. NVP-AUY922 causes p23 dissociation from the HSP90 complex and can then recruit HSP70 to the HSP90 complex. [1] After the treatment with NVP-AUY922, expression of receptor tyrosine kinases including VEGFR1, 2, 3 and PDGFRɑ is decreased. A decrease is also noticed in the expression of Akt and phospho-Akt. Meanwhile, treatment with NVP-AUY922 causes decreased expression of HER-2 in NCI-N87 cells. NVP-AUY922 treatment results in binding of HSP90 to client proteins and setting them up as targets for degradation by the proteasome. NVP-AUY922 can influence cell growth by affecting multiple signaling pathways. In addition, treatment with the proteasome inhibitor, MG132, restores expression of thymidylate synthase, which is decreased by NVP-AUY922. NVP-AUY922 increases the expression of cleaved caspase-3 leading to apoptosis in HSC-2 cells.[1]
Kinase Assay Kinase assay
NVP-AUY922 is dissolved in DMSO at a concentration of 10 mM. NVP-AUY922 is assessed against HSP90α, HSP90β, GRP94, TRAP-1, HSP72, and topoisomerase II. Profiling against a panel of kinases has been carried out and screening against a panel of additional enzymes and receptors is performed at Cerep.
Cell Research Cell lines Human gastric cancer cells NCI-N87
Concentrations 1 μM
Incubation Time 3 days
Method Human gastric cancer cells NCI-N87 (5-7 ×103 in 50 μL/well) are seeded in 96-well plates and incubated at 37 °C for 24 hours, followed by NVP-AUY922 treatment for 1-3 days at 37 °C. After treatment, the cells are assayed by MTT method and analyzed by microplate reader.
Experimental Result Images Methods Biomarkers Images PMID
Western blot p-ALK / ALK / p-AKT / AKT / p-ERK / ERK / TβRI / TβRII E-cadherin / Cleaved PARP / Bim HSP70 / Grp94 / Grp78 / p-eIF2α / CHOP / IRE1α / p-JNK CDK4 / HMGA2 23993685
Growth inhibition assay Cell viability 26893968
In Vivo
In vivo Treatment with NVP-AUY922 causes a robust antitumor response and inhibits p-Akt and VEGF expression in an HSC-2 xenograft model. [2] In BT474, NVP-AUY922 shows complete loss of ERBB2 and substantial depletion of ERα, in addition to reductions in CDK4 and phospho-ERK1/2. [3]
Animal Research Animal Models Female NCr athymic mice bearing WM266.4 human melanoma xenografts
Dosages 50 mg/kg
Administration Administered via i.v. or i.p.
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT01772797 Completed
Anaplastic Lymphoma Kinase (ALK)|Non-small Cell Lung Cancer
Novartis Pharmaceuticals|Novartis
June 2013 Phase 1
NCT01752400 Completed
Non Small Cell Lung Cancer
Massachusetts General Hospital
January 2013 Phase 2
NCT01613950 Completed
Stomach Neoplasms Esophageal Neoplasms Metastatic Gastric Cancer Mutated PI3KCA Protein Overexpressed HER2 Protein
Novartis Pharmaceuticals|Novartis
December 2012 Phase 1
NCT01484860 Terminated
Adenocarcinoma of the Pancreas|Metastatic Disease
University Health Network Toronto|Novartis Pharmaceuticals
January 2012 Phase 2
NCT01402401 Terminated
Advanced Gastric Cancer
Novartis Pharmaceuticals|Novartis
November 2011 Phase 2

Chemical Information & Solubility

Molecular Weight 465.54 Formula

C26H31N3O5

CAS No. 747412-49-3 SDF Download Luminespib (NVP-AUY922) SDF
Smiles CCNC(=O)C1=NOC(=C1C2=CC=C(C=C2)CN3CCOCC3)C4=CC(=C(C=C4O)O)C(C)C
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 93 mg/mL ( (199.76 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 31 mg/mL

Water : Insoluble


Molecular Weight Calculator

In vivo
Batch:

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In vivo Formulation Calculator

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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