Luminespib (AUY-922, NVP-AUY922)

Catalog No.S1069 Synonyms: VER-52296

Luminespib (AUY-922, NVP-AUY922) Chemical Structure

Molecular Weight(MW): 465.54

Luminespib (AUY-922, NVP-AUY922) is a highly potent HSP90 inhibitor for HSP90α/β with IC50 of 13 nM /21 nM in cell-free assays, weaker potency against the HSP90 family members GRP94 and TRAP-1, exhibits the tightest binding of any small-molecule HSP90 ligand. Phase 2.

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In DMSO USD 320 In stock
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3 Customer Reviews

  • U2OS_exo cells were incubated with AUY922 for 20 h at the indicated concentrations before stimulation with TNFα (30 ng/mL) for 30 min and immunostaining to detect NF-κB (p65). DMSO 1%, cells stimulated by TNFα in the absence of AUY922. Representative pictures used to quantify nuclear and cytoplasmic localization of NF-κB.

    Proc Natl Acad Sci USA, 2014, 111(15): E1528–37 . Luminespib (AUY-922, NVP-AUY922) purchased from Selleck.

    J Biol Chem 2013 288(23), 16308-20. Luminespib (AUY-922, NVP-AUY922) purchased from Selleck.

  • Western blots show the molecular signature of HSP90 inhibition by NVP-AUY922  (ie, induction of HSP72 and depletion of client proteins such as ERBB2, CRAF and CDK4) in BT474 breast cancer cell line. GAPDH was used as loading control.

     

     

    2011 Dr. Swee Sharp and Professor Paul Workman from Cancer Research UK. Luminespib (AUY-922, NVP-AUY922) purchased from Selleck.

Purity & Quality Control

Choose Selective HSP (e.g. HSP90) Inhibitors

Biological Activity

Description Luminespib (AUY-922, NVP-AUY922) is a highly potent HSP90 inhibitor for HSP90α/β with IC50 of 13 nM /21 nM in cell-free assays, weaker potency against the HSP90 family members GRP94 and TRAP-1, exhibits the tightest binding of any small-molecule HSP90 ligand. Phase 2.
Targets
HSP90α [1]
(Cell-free assay)
HSP90β [1]
(Cell-free assay)
13 nM 21 nM
In vitro

NVP-AUY922 inhibits proliferation of various human cancer cell lines in vitro, with an average GI50 of 9 nM. [1] The IC50 values of NVP-AUY922 fall in the range of 2 to 40 nM in these gastric cancer cell lines. IC50 value for the BEAS-2B cells is 28.49 nM. Treatment with NVP-AUY922 does not influence the expression of HSP90, but expression of HSP70 gets elevated by NVP-AUY922 treatment. NVP-AUY922 increases the binding of HSP70 to HSP90. NVP-AUY922 causes p23 dissociation from the HSP90 complex and can then recruit HSP70 to the HSP90 complex. [1] After the treatment with NVP-AUY922, expression of receptor tyrosine kinases including VEGFR1, 2, 3 and PDGFRɑ is decreased. A decrease is also noticed in the expression of Akt and phospho-Akt. Meanwhile, treatment with NVP-AUY922 causes decreased expression of HER-2 in NCI-N87 cells. NVP-AUY922 treatment results in binding of HSP90 to client proteins and setting them up as targets for degradation by the proteasome. NVP-AUY922 can influence cell growth by affecting multiple signaling pathways. In addition, treatment with the proteasome inhibitor, MG132, restores expression of thymidylate synthase, which is decreased by NVP-AUY922. NVP-AUY922 increases the expression of cleaved caspase-3 leading to apoptosis in HSC-2 cells.[1]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
CMK NYi2U3o3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHrZPIFKSzVyPUCuNFAxOTJ3IN88US=> NH;POZhUSU6JRWK=
MV-4-11 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnPpTWM2OD1yLkCwNFU2QCEQvF2= NU\1OJIyW0GQR1XS
NALM-6 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUnxU41qUUN3ME2wMlAxODh2MjFOwG0> MYLTRW5ITVJ?
HOS MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXfUOIdiUUN3ME2wMlAxOTN6IN88US=> NVzu[mZtW0GQR1XS
HT-144 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFfzeIFKSzVyPUCuNFAyPTVizszN NVPST4ZyW0GQR1XS
SW1710 NVrP[2xZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M13EVWlEPTB;MD6wNFE5PiEQvF2= MkjYV2FPT0WU
TE-8 NHK0VnVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2DvfWlEPTB;MD6wNFI{PyEQvF2= M4HjXnNCVkeHUh?=
ES1 NUnzXVhNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{LtOGlEPTB;MD6wNFI3PiEQvF2= MW\TRW5ITVJ?
CCF-STTG1 Mn;4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV3ESHNWUUN3ME2wMlAxOjl5IN88US=> NEPTbYJUSU6JRWK=
PSN1 NYHaVmtwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mnn6TWM2OD1yLkCwN|E5KM7:TR?= NYDmb|I6W0GQR1XS
CAL-51 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWPCWFZtUUN3ME2wMlAxOzJ3IN88US=> NHLyRZJUSU6JRWK=
MCF7 Mm\6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{HOc2lEPTB;MD6wNFM{PSEQvF2= NILtNJlUSU6JRWK=
SK-HEP-1 NFTxV41Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVnJR|UxRTBwMECzN|Yh|ryP MnKxV2FPT0WU
LCLC-103H Ml65S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUXJR|UxRTBwMEC0N{DPxE1? MV7TRW5ITVJ?
HMV-II M{HhZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlXYTWM2OD1yLkCwOFQ6KM7:TR?= NGri[W9USU6JRWK=
MES-SA NEPUZY9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoXUTWM2OD1yLkCwOFUzKM7:TR?= MmX1V2FPT0WU
SK-LMS-1 NF\xblFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2TRTmlEPTB;MD6wNFQ2QCEQvF2= MYrTRW5ITVJ?
639-V M2fUcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWLJR|UxRTBwMEC0PFUh|ryP NHTMOnRUSU6JRWK=
SIG-M5 NWXpflNoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEjVNWxKSzVyPUCuNFA1QDlizszN NUjxWFBtW0GQR1XS
LOUCY NVjjOXl6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYHyfpBmUUN3ME2wMlAxPTB3IN88US=> M{PVd3NCVkeHUh?=
HSC-2 MmnKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVnFfJB5UUN3ME2wMlAxPTF6IN88US=> NVn2dYZmW0GQR1XS
EW-13 NHfsZWFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnqzTWM2OD1yLkCwOVE5KM7:TR?= MXfTRW5ITVJ?
RT-112 MoPFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3TtOmlEPTB;MD6wNFU{PSEQvF2= MU\TRW5ITVJ?
NKM-1 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYLJR|UxRTBwMEC1OFch|ryP NGHWeFRUSU6JRWK=
KYSE-180 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkPVTWM2OD1yLkCwOVg3KM7:TR?= MkfYV2FPT0WU
SW1783 NE[xV4lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NETxb3ZKSzVyPUCuNFA2QTFizszN M1fCTnNCVkeHUh?=
A431 MnXxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWHJR|UxRTBwMEC2NFch|ryP MYnTRW5ITVJ?
SK-OV-3 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3jzdWlEPTB;MD6wNFY{KM7:TR?= MV3TRW5ITVJ?
RPMI-7951 NUT5[4xLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlK2TWM2OD1yLkCwOlMyKM7:TR?= NI\WeVhUSU6JRWK=
Capan-2 NUfXcldJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHnDWnVKSzVyPUCuNFA3OzhizszN M2jpRnNCVkeHUh?=
HSC-3 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYnJR|UxRTBwMEC2OFEh|ryP M3u5PXNCVkeHUh?=
786-0 M1TLdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUTsUG5jUUN3ME2wMlAxPjZ|IN88US=> NY\NcY1tW0GQR1XS
Daoy MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmjXTWM2OD1yLkCwOlk2KM7:TR?= MXXTRW5ITVJ?
KGN NHvsWItIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1LMdmlEPTB;MD6wNFcxOyEQvF2= MoTzV2FPT0WU
EW-16 M{TIOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWLXVlNXUUN3ME2wMlAxPzR7IN88US=> MWXTRW5ITVJ?
EW-7 M{\LbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2TlfGlEPTB;MD6wNFc2PCEQvF2= NHnuXFRUSU6JRWK=
IGROV-1 NUHqPVZnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUPJR|UxRTBwMEC4NVQh|ryP NVXyW4JPW0GQR1XS
8505C NF:5NJRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGm4XpRKSzVyPUCuNFA5OjFizszN NFPqdHRUSU6JRWK=
RKO M{n0b2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3LwOmlEPTB;MD6wNFgzPiEQvF2= NF\2TIZUSU6JRWK=
GDM-1 MnrWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXvJR|UxRTBwMEC4OEDPxE1? NU[0bFM{W0GQR1XS
IST-MEL1 MmT5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYjJR|UxRTBwMEC4OVIh|ryP MXzTRW5ITVJ?
RPMI-6666 NIWy[IJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGfORXhKSzVyPUCuNFA5PTJizszN NHnUbYtUSU6JRWK=
SNG-M MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVewNXFyUUN3ME2wMlAxQDV4IN88US=> NEnmVJRUSU6JRWK=
KS-1 MliwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIqxemxKSzVyPUCuNFA5PTlizszN MoLHV2FPT0WU
RXF393 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYrkPYw2UUN3ME2wMlAxQDZizszN NXnjN5lFW0GQR1XS
CAL-12T NXHa[XVlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXWye2M6UUN3ME2wMlAxQTJ{IN88US=> MXXTRW5ITVJ?
BFTC-905 M2PEXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUnQ[FNDUUN3ME2wMlAxQTN6IN88US=> MYjTRW5ITVJ?
SK-MES-1 M{DMeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH21cWJKSzVyPUCuNFA6PDVizszN NGPwXWdUSU6JRWK=
BB30-HNC M33UVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF3KZoRKSzVyPUCuNFA6PTJizszN NIHYe|hUSU6JRWK=
AN3-CA MlrIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUPJR|UxRTBwMEGwNVch|ryP NWrnU3NZW0GQR1XS
EFO-27 M2T2d2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXi3fZNNUUN3ME2wMlAyODF5IN88US=> M4nERnNCVkeHUh?=
G-401 MofwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NITmTIdKSzVyPUCuNFExOjVizszN MYLTRW5ITVJ?
BPH-1 MojwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXzHO4RqUUN3ME2wMlAyODNizszN NYDxN2lHW0GQR1XS
NCI-H727 MnfTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUnqWoRlUUN3ME2wMlAyODNizszN NVfaZ2x[W0GQR1XS
SNU-423 MnjzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUDaPYNqUUN3ME2wMlAyODV|IN88US=> M{TYSnNCVkeHUh?=
KYSE-270 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWHSfoV1UUN3ME2wMlAyODV7IN88US=> NXHtcHN5W0GQR1XS
AGS NHPLZmtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3;zeWlEPTB;MD6wNVA3OSEQvF2= NHz1OWhUSU6JRWK=
NCI-H2228 NIHPSGFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXHJR|UxRTBwMEGwOlQh|ryP MX\TRW5ITVJ?
SW954 NIHibppIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2LrNGlEPTB;MD6wNVA4OSEQvF2= M4PZVXNCVkeHUh?=
769-P NXTROoF6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWTye5l4UUN3ME2wMlAyODd|IN88US=> NV3UUVZkW0GQR1XS
BB49-HNC MmjZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYjJR|UxRTBwMEGwO|ch|ryP MWTTRW5ITVJ?
IA-LM NGTYPWhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1;JTmlEPTB;MD6wNVA5PiEQvF2= M4jvb3NCVkeHUh?=
NB69 M3PITGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn;BTWM2OD1yLkCxNVAzKM7:TR?= Ml\LV2FPT0WU
C8166 Mn;XS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{fHVmlEPTB;MD6wNVEzQSEQvF2= MlTFV2FPT0WU
NCI-H1299 M3zve2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3PHeGlEPTB;MD6wNVE2PCEQvF2= NFe5U2JUSU6JRWK=
YKG-1 Ml7WS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGXWW4RKSzVyPUCuNFEyPiEQvF2= MlexV2FPT0WU
PANC-03-27 NWjSfGRCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3nJfmlEPTB;MD6wNVE3OiEQvF2= NWXudIx4W0GQR1XS
YT MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmfCTWM2OD1yLkCxNVc6KM7:TR?= MU\TRW5ITVJ?
CAL-85-1 NV;RWVJUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1m3emlEPTB;MD6wNVE6OiEQvF2= M3Hi[nNCVkeHUh?=
GT3TKB NEmyXopIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHz1T5hKSzVyPUCuNFEzODJizszN M{n2V3NCVkeHUh?=
BB65-RCC M3H4T2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF;PbHdKSzVyPUCuNFEzODRizszN MkLjV2FPT0WU
ES6 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3\WTWlEPTB;MD6wNVI3OSEQvF2= MUnTRW5ITVJ?
MHH-ES-1 M2e4bWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH;S[plKSzVyPUCuNFEzPjNizszN MlXoV2FPT0WU
QIMR-WIL MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX3JR|UxRTBwMEGyOlkh|ryP MnvsV2FPT0WU
SNU-C2B Mn;wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXXWOmxEUUN3ME2wMlAyOjd{IN88US=> M3PvTHNCVkeHUh?=
OCI-AML2 NIKyR4FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWPJR|UxRTBwMEGyPFEh|ryP NFLue2xUSU6JRWK=
DU-145 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2HmTGlEPTB;MD6wNVI6KM7:TR?= NXX1XJhMW0GQR1XS
SW982 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWLRcJZ4UUN3ME2wMlAyOjl|IN88US=> MonhV2FPT0WU
MFH-ino MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVzJR|UxRTBwMEGyPVMh|ryP MVTTRW5ITVJ?
A427 NX\uWIN3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEi2WWtKSzVyPUCuNFEzQTlizszN M3u3VnNCVkeHUh?=
LCLC-97TM1 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIS1eVFKSzVyPUCuNFE{KM7:TR?= MXrTRW5ITVJ?
AM-38 M3zlXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoPwTWM2OD1yLkCxN|AzKM7:TR?= M2XaeXNCVkeHUh?=
K5 NED5NWRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVHJR|UxRTBwMEGzNFgh|ryP MlvmV2FPT0WU
T84 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFTrZ4NKSzVyPUCuNFE{OzFizszN NYHxOoJpW0GQR1XS
TE-15 NYX1XHd6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWTKXWNtUUN3ME2wMlAyOzN4IN88US=> M3uyb3NCVkeHUh?=
NCI-H460 NXqxTXl3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnSxTWM2OD1yLkCxN|M3KM7:TR?= MWTTRW5ITVJ?
NTERA-S-cl-D1 MnvWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFruRYtKSzVyPUCuNFE{OzlizszN NV;IVVJ3W0GQR1XS
KYSE-450 NYPQcGJyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1HWUmlEPTB;MD6wNVM1QSEQvF2= Mny2V2FPT0WU
H4 NILpfmhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYnNNo5YUUN3ME2wMlAyOzZ4IN88US=> M4jmNHNCVkeHUh?=
LC-2-ad MmrES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4jPT2lEPTB;MD6wNVM4KM7:TR?= NUHHc21IW0GQR1XS
GAMG MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUjJR|UxRTBwMEGzO|Eh|ryP M2f5ZnNCVkeHUh?=
TK10 MmT1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnzCTWM2OD1yLkCxN|gzKM7:TR?= MlixV2FPT0WU
NCI-H2122 M3PyXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NG\yXXdKSzVyPUCuNFE{QDRizszN M{fzUnNCVkeHUh?=
KM12 Mle0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX3CPINyUUN3ME2wMlAyOzl7IN88US=> NUXPc5dEW0GQR1XS
CAL-39 M3Ttcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{HVU2lEPTB;MD6wNVQzKM7:TR?= NGrFdndUSU6JRWK=
RPMI-2650 NE\vRo5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2XmVGlEPTB;MD6wNVQ{OiEQvF2= NVn5c3dRW0GQR1XS
KYSE-510 NIHYN4xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUHqPYRqUUN3ME2wMlAyPDR{IN88US=> MX;TRW5ITVJ?
KALS-1 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NImxdlRKSzVyPUCuNFE1PjZizszN MXXTRW5ITVJ?
NCI-H1648 MlSxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlrsTWM2OD1yLkCxOFk6KM7:TR?= M1jQe3NCVkeHUh?=
ES4 M17vTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHnVN3hKSzVyPUCuNFE2ODJizszN NV\4NlhjW0GQR1XS
C-33-A MlrMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4S4VmlEPTB;MD6wNVUxQSEQvF2= NEPKVWtUSU6JRWK=
MIA-PaCa-2 NWj4dWw3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWnxRXg1UUN3ME2wMlAyPTB7IN88US=> NI\Ye3hUSU6JRWK=
Becker MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4P5c2lEPTB;MD6wNVUyPCEQvF2= MYrTRW5ITVJ?
HOP-62 NH62VFNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkPLTWM2OD1yLkCxOVQzKM7:TR?= MXPTRW5ITVJ?
TE-1 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVTJR|UxRTBwMEG1PFEh|ryP M{C2dHNCVkeHUh?=
KYSE-410 M2nHVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlSyTWM2OD1yLkCxOVg3KM7:TR?= M4TvdHNCVkeHUh?=
NOS-1 NITr[oJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1PlRWlEPTB;MD6wNVU6OyEQvF2= MnS1V2FPT0WU
MEL-HO MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUTMRlkzUUN3ME2wMlAyPjR|IN88US=> MmL4V2FPT0WU
NCI-H1650 M3nOTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUHJR|UxRTBwMEG2OFYh|ryP MYTTRW5ITVJ?
VMRC-RCZ MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX;JR|UxRTBwMEG2OVEh|ryP NIfPRlVUSU6JRWK=
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OS-RC-2 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml71TWM2OD1yLkCzN|k3KM7:TR?= NXjhXHBDW0GQR1XS
SF268 NFPWOopIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXnITG9FUUN3ME2wMlA{PDBzIN88US=> NVnQe4pRW0GQR1XS
BV-173 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFvZdHBKSzVyPUCuNFM1OjZizszN MUjTRW5ITVJ?
DMS-273 NYL0e5NDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3fy[WlEPTB;MD6wN|Q4QSEQvF2= Ml7aV2FPT0WU
22RV1 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3fEVmlEPTB;MD6wN|UxPyEQvF2= MnznV2FPT0WU
ES8 M3vUfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2HtNWlEPTB;MD6wN|U{QCEQvF2= MXTTRW5ITVJ?
KYSE-150 MkOzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmXWTWM2OD1yLkCzOlA5KM7:TR?= M{H5dHNCVkeHUh?=
HCC1569 NH;NV3FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnTxTWM2OD1yLkCzOlA5KM7:TR?= MmG5V2FPT0WU
NB5 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWf1SnVlUUN3ME2wMlA{PjF|IN88US=> NVziN2lWW0GQR1XS
G-402 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFHSOY1KSzVyPUCuNFM3OTRizszN M1zvVnNCVkeHUh?=
NCI-H1693 M3vkemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkfsTWM2OD1yLkCzOlE4KM7:TR?= M1exTHNCVkeHUh?=
LB2241-RCC M1vGcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{XKfWlEPTB;MD6wN|Y1OiEQvF2= MWfTRW5ITVJ?
KP-4 M4Dzb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWP2SYlpUUN3ME2wMlA{PjZ|IN88US=> NH;IV3NUSU6JRWK=
ML-2 M4XNemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnXBTWM2OD1yLkCzOlcyKM7:TR?= NEP0OYNUSU6JRWK=
KU812 M{jFN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3e3VmlEPTB;MD6wN|Y5PCEQvF2= MnXiV2FPT0WU
LS-411N NIXTZ|JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXnJR|UxRTBwMEO3N|Eh|ryP NVXSR3FXW0GQR1XS
OAW-42 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{f3dWlEPTB;MD6wN|c1PyEQvF2= NFq5eYFUSU6JRWK=
HCC38 NH3x[41Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVzJR|UxRTBwMEO3O|Eh|ryP NXXGfVdyW0GQR1XS
Ca-Ski NGfFTGJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHXGOpFKSzVyPUCuNFM4QDRizszN NEPOZ|ZUSU6JRWK=
Calu-3 MnzWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn7BTWM2OD1yLkCzO|g6KM7:TR?= NELOTWVUSU6JRWK=
KYSE-70 NEnMZnJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF3ufmRKSzVyPUCuNFM5OTJizszN NIW3RlRUSU6JRWK=
D-392MG MorZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mlm4TWM2OD1yLkCzPFQzKM7:TR?= MV7TRW5ITVJ?
OVCAR-4 M3r6T2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mm\6TWM2OD1yLkCzPFU5KM7:TR?= M1vldXNCVkeHUh?=
Detroit562 MmrYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUDBcItpUUN3ME2wMlA{QDd{IN88US=> MY\TRW5ITVJ?
HEL NYG2NpVXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXLjXGRVUUN3ME2wMlA{QDlzIN88US=> MXTTRW5ITVJ?
MONO-MAC-6 NHqyNGVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MofvTWM2OD1yLkCzPFk{KM7:TR?= M3KyRnNCVkeHUh?=
LoVo M3:x[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUPJR|UxRTBwMEO5N|Mh|ryP MkjEV2FPT0WU
U-2-OS MmT4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3\NdmlEPTB;MD6wN|k{PSEQvF2= MUPTRW5ITVJ?
A172 NUK1PZA4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFTLOpdKSzVyPUCuNFM6PSEQvF2= Ml7kV2FPT0WU
OCUB-M NX7jSpV5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkTPTWM2OD1yLkCzPVYyKM7:TR?= Mm\IV2FPT0WU
SW48 M3rGbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2ntcmlEPTB;MD6wOFA{OSEQvF2= Ml7lV2FPT0WU
HC-1 NX;QPWtUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUHJR|UxRTBwMESwOlkh|ryP NV\Z[lhJW0GQR1XS
KOSC-2 NUD6Umh5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml;vTWM2OD1yLkC0NVEh|ryP MWTTRW5ITVJ?
HDLM-2 M17YZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUTSfW5QUUN3ME2wMlA1OTF2IN88US=> MXPTRW5ITVJ?
CTV-1 MoP4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1P5OGlEPTB;MD6wOFEyPiEQvF2= NHLmfXlUSU6JRWK=
SH-4 NGjIUWRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWnMZ|JoUUN3ME2wMlA1OTRzIN88US=> NWHabmVWW0GQR1XS
SW756 NIOw[FRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1T0cmlEPTB;MD6wOFE2PyEQvF2= NXrrfHdqW0GQR1XS
GCT MnHCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnLxTWM2OD1yLkC0NVYyKM7:TR?= MmCwV2FPT0WU
CHL-1 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHzXTJVKSzVyPUCuNFQyPjlizszN MnzQV2FPT0WU
LAMA-84 NV7sN5J2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoG4TWM2OD1yLkC0NVcyKM7:TR?= NV\yb3lKW0GQR1XS
LS-1034 NYL5eGpvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXnIeXd3UUN3ME2wMlA1OTlzIN88US=> NUXHNI9oW0GQR1XS
NCI-H358 NFjlWYlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF;uT5pKSzVyPUCuNFQzOTJizszN MVXTRW5ITVJ?
NB13 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGDCO3hKSzVyPUCuNFQzOjdizszN Mlu1V2FPT0WU
TE-9 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYTVZWYzUUN3ME2wMlA1OjN5IN88US=> NEfobnhUSU6JRWK=
OE33 M4DZUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1TONWlEPTB;MD6wOFI1OSEQvF2= MV\TRW5ITVJ?
CAL-120 NUflfG9kT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF;lUZRKSzVyPUCuNFQzPDFizszN M3\MNnNCVkeHUh?=
DJM-1 NFvpR3pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1yzXmlEPTB;MD6wOFI4OiEQvF2= MX;TRW5ITVJ?
SK-MEL-24 MnviS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXHGNpVtUUN3ME2wMlA1Ojh|IN88US=> M3PrTnNCVkeHUh?=
VA-ES-BJ Mo[5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVrJR|UxRTBwMESyPVIh|ryP MkXMV2FPT0WU
MMAC-SF NVfUcWZ5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlvCTWM2OD1yLkC0Nlk4KM7:TR?= NFjsTGxUSU6JRWK=
MZ7-mel NIPQOllIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV\JR|UxRTBwMESzN{DPxE1? NETyNo5USU6JRWK=
BxPC-3 NGXrWVVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3\rVWlEPTB;MD6wOFM1OSEQvF2= NGLjb3hUSU6JRWK=
HT-29 NGPkW5BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF[3PZRKSzVyPUCuNFQ{PTdizszN MVzTRW5ITVJ?
SK-MEL-30 M2nqd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX;xbos5UUN3ME2wMlA1OzZ{IN88US=> MmXyV2FPT0WU
CAL-33 M2\tbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYrJR|UxRTBwMESzO|Uh|ryP NXTRe3VKW0GQR1XS
COLO-680N NXz3Tmx{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1LzUGlEPTB;MD6wOFQxPyEQvF2= NX:3fIY5W0GQR1XS
NH-12 MmXGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIjme4hKSzVyPUCuNFQ1PCEQvF2= MX7TRW5ITVJ?
HCC1937 M4r3TGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEHDeWdKSzVyPUCuNFQ1PTZizszN NFXmeolUSU6JRWK=
IMR-5 MoGxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXXJR|UxRTBwMES0PUDPxE1? Ml3nV2FPT0WU
MC-CAR NH6xfINIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2\UcGlEPTB;MD6wOFU3QSEQvF2= MX7TRW5ITVJ?
NCI-H747 NWXTcpVzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4DPZmlEPTB;MD6wOFU4KM7:TR?= M1uzNnNCVkeHUh?=
NCI-H1792 NWq3T3M5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MULJR|UxRTBwMES1PFEh|ryP M{LucHNCVkeHUh?=
SW13 M1XLbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3fJU2lEPTB;MD6wOFU6KM7:TR?= MV3TRW5ITVJ?
MLMA MlvRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnzaTWM2OD1yLkC0OlA6KM7:TR?= NXvqRZE4W0GQR1XS
U251 NUTQfHRkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGrTU4tKSzVyPUCuNFQ4PjNizszN NXryPWI4W0GQR1XS
U031 NXizUGVWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MofCTWM2OD1yLkC0O|cyKM7:TR?= NHTyd5lUSU6JRWK=
ME-180 M4HoWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX\3ZYFOUUN3ME2wMlA1Pzh{IN88US=> NED4cm1USU6JRWK=
SK-MEL-3 Ml\vS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHvqcGRKSzVyPUCuNFQ5ODJizszN MXfTRW5ITVJ?
MOLT-4 M1LC[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYDC[FVSUUN3ME2wMlA1QDB|IN88US=> M4\oT3NCVkeHUh?=
PF-382 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnnlTWM2OD1yLkC0PFI3KM7:TR?= M4L1bnNCVkeHUh?=
NUGC-3 Ml:5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4f5TmlEPTB;MD6wOFgzPyEQvF2= NUHYSW9qW0GQR1XS
NCI-H1417 NVjscVB7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXzJR|UxRTBwMES4PUDPxE1? MmfrV2FPT0WU
COLO-205 NEDKeZNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXXJR|UxRTBwMES5NVkh|ryP MWPTRW5ITVJ?
TE-441-T M1WzWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV65WJZCUUN3ME2wMlA1QTNizszN MXzTRW5ITVJ?
MKN1 NUnpXWJYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVKySXY5UUN3ME2wMlA1QTNizszN MYDTRW5ITVJ?
UM-UC-3 NWWzcHVrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml\sTWM2OD1yLkC0PVUh|ryP MVLTRW5ITVJ?
SF126 NFfoNXdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2fkRmlEPTB;MD6wOVAyKM7:TR?= MojYV2FPT0WU
LB1047-RCC NHjtNmJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYXJR|UxRTBwMEWwN|Eh|ryP NVjtZ2l2W0GQR1XS
A253 MmXyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYXJR|UxRTBwMEWwOVIh|ryP MnnGV2FPT0WU
NCI-H1963 M{P0NGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnnBTWM2OD1yLkC1NVc3KM7:TR?= NYjUW|JpW0GQR1XS
VM-CUB-1 M3nMcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVXse5U{UUN3ME2wMlA2OzFzIN88US=> M2P3OHNCVkeHUh?=
T-24 MnrxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkTaTWM2OD1yLkC1N|g1KM7:TR?= MVzTRW5ITVJ?
K-562 Ml:2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXGwOocxUUN3ME2wMlA2Ozh5IN88US=> NX33O41JW0GQR1XS
ARH-77 NVfXcY9PT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2L0S2lEPTB;MD6wOVM6PSEQvF2= NGfVTZZUSU6JRWK=
CA46 M1jDcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWiwZWc5UUN3ME2wMlA2PDNizszN MmrXV2FPT0WU
HCC70 M4r3[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVTybpdHUUN3ME2wMlA2PDV{IN88US=> NFfNNo9USU6JRWK=
ST486 MmH0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIX2PWxKSzVyPUCuNFU2OjVizszN NYf1blRoW0GQR1XS
COLO-741 Mn\6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmLlTWM2OD1yLkC1OVMyKM7:TR?= MVvTRW5ITVJ?
SK-PN-DW NF72XI9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M37seGlEPTB;MD6wOVU5QCEQvF2= NIOyeoNUSU6JRWK=
BL-41 MoC5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mo\lTWM2OD1yLkC1OVk3KM7:TR?= NYPpdpNGW0GQR1XS
D-263MG M3PY[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYHJR|UxRTBwMEW2PFMh|ryP NG[zWFdUSU6JRWK=
KE-37 Mn;wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NInENHZKSzVyPUCuNFU3QDNizszN MkTZV2FPT0WU
LU-134-A MnTnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnfMTWM2OD1yLkC1O|E2KM7:TR?= M1vNR3NCVkeHUh?=
HCC2157 MnvJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFTFV|RKSzVyPUCuNFU4OzNizszN NV;XemFUW0GQR1XS
GAK MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml3rTWM2OD1yLkC1O|M1KM7:TR?= MYPTRW5ITVJ?
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KMOE-2 MkGxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{PMVGlEPTB;MD6wOVc1QSEQvF2= M1X1RXNCVkeHUh?=
SW1573 NXi5OoY6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEe5cpNKSzVyPUCuNFU5ODJizszN MnHoV2FPT0WU
SCC-9 NWTu[JZlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkjxTWM2OD1yLkC1PFch|ryP M4rJfXNCVkeHUh?=
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BHT-101 M1PXU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX3JR|UxRTBwMEW4O|Yh|ryP NWnLN3hzW0GQR1XS
NCI-H1770 MlnpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1:0PGlEPTB;MD6wOVg4QSEQvF2= M3rrNnNCVkeHUh?=
UACC-893 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUnHTYJTUUN3ME2wMlA2QDl4IN88US=> MVrTRW5ITVJ?
NCI-H226 NIXMcJBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M33vZ2lEPTB;MD6wOVk5QCEQvF2= MVHTRW5ITVJ?
HLE NWTtT4s3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYjrbWx6UUN3ME2wMlA3ODh{IN88US=> MW\TRW5ITVJ?
NCI-H1703 NV3mOZpVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmP2TWM2OD1yLkC2NVc5KM7:TR?= M{foVnNCVkeHUh?=
KURAMOCHI M3z4Wmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXX3PXQxUUN3ME2wMlA3OTh7IN88US=> MnfBV2FPT0WU
RH-1 NXu0flNwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXPJR|UxRTBwME[yN{DPxE1? NGDkPGpUSU6JRWK=
DSH1 NUfqSFFET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHrEUZJKSzVyPUCuNFYzPyEQvF2= MmqyV2FPT0WU
CAMA-1 M{fONmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYHJR|UxRTBwME[zNFMh|ryP NV7zfpU3W0GQR1XS
NCI-H1437 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUHJR|UxRTBwME[zNlgh|ryP NFrUTIlUSU6JRWK=
HuP-T4 M1npfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{ficmlEPTB;MD6wOlU5PiEQvF2= MlP5V2FPT0WU
HCT-15 NVHubVhIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{nj[WlEPTB;MD6wOlU6PyEQvF2= NF\lR29USU6JRWK=
NCCIT NGjKZ3VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGTH[ZZKSzVyPUCuNFY3ODRizszN M4jRZnNCVkeHUh?=
BOKU M1Kzd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV3Yb3QxUUN3ME2wMlA3Pjd2IN88US=> NVzhclg4W0GQR1XS
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L-363 M2ntVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX\tcXhbUUN3ME2wMlA3QTBzIN88US=> NXfmR3dNW0GQR1XS
KNS-81-FD M{LvTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV70e4M2UUN3ME2wMlA3QTF6IN88US=> NIT0d3pUSU6JRWK=
SU-DHL-1 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlPyTWM2OD1yLkC2PVIh|ryP M3PQVXNCVkeHUh?=
HuH-7 NWnEcnViT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVrnSmNSUUN3ME2wMlA4ODN3IN88US=> NEjLPGtUSU6JRWK=
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RO82-W-1 NIHLe4hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWHJR|UxRTFwM{OzN|kh|ryP MknFV2FPT0WU
NCI-H1581 NXvhNZJ4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MorZTWM2OD1zLkO1Olg4KM7:TR?= MVzTRW5ITVJ?
NCI-H748 NWjTXmN2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF;nR5JKSzVyPUGuN|U4OzhizszN NUm4cmZ5W0GQR1XS
HCC1187 NIjXW3dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkjGTWM2OD1zLkW1OVIzKM7:TR?= NXzuTGplW0GQR1XS
EoL-1-cell NVLYNYVIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFrWcpRKSzVyPUGuOVg5QDlizszN Ml\ZV2FPT0WU
HuO-3N1 NYHtUlY1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGf0enZKSzVyPUGuPFM1OTJizszN NFvSUXBUSU6JRWK=
NCI-H1793 NV7IemVOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NILiWXpKSzVyPUGuPFc2QTNizszN NGXuTldUSU6JRWK=
Caov-3 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml7ZTWM2OD1{LkCwOlI2KM7:TR?= M1rSfnNCVkeHUh?=
JAR MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NY[xV3ZPUUN3ME2yMlA4QTJizszN NVfvdIlvW0GQR1XS
SK-MEL-28 NEf5OmNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoHLTWM2OD1{LkG4NFk5KM7:TR?= NXr0dIsyW0GQR1XS
EM-2 NXTWdYxWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1\sd2lEPTB;Mj6yNFI6OyEQvF2= NHH2O29USU6JRWK=
Mewo NXrN[|BET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MULJR|UxRTJwMkKyOlUh|ryP NXHKclA4W0GQR1XS
NCI-H720 NWrS[4k6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnX4TWM2OD1{LkK2OVg2KM7:TR?= M2LwZXNCVkeHUh?=
CAL-54 Ml;zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUPJR|UxRTJwMk[3PVUh|ryP NFzJN4RUSU6JRWK=
MC116 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlO4TWM2OD1{LkO2N|k4KM7:TR?= MkTYV2FPT0WU
DG-75 M4XwSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUTJR|UxRTJwNEi1O|Yh|ryP MVPTRW5ITVJ?
HCC1143 M1O2VWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{\hRmlEPTB;Mj61NFY2QCEQvF2= NIex[nVUSU6JRWK=
FTC-133 NH2wcm9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlvjTWM2OD1{LkWzOlg6KM7:TR?= Mk\6V2FPT0WU
AsPC-1 M3fCVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHjxdXpKSzVyPUKuOVM6OjlizszN MnvaV2FPT0WU
NCI-H889 MkHlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV[5bYlWUUN3ME2yMlU3PzB4IN88US=> Ml;NV2FPT0WU
HT55 M3XqTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVzGU|BxUUN3ME2yMlYzODF7IN88US=> MonQV2FPT0WU
UMC-11 M3fNRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX\JR|UxRTJwN{i3NVUh|ryP NF\qNldUSU6JRWK=
P12-ICHIKAWA MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVH4WVc4UUN3ME2yMlgzODR4IN88US=> MY\TRW5ITVJ?
HCC1395 M{j5ZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MorkTWM2OD1{Lkm4OlAzKM7:TR?= NEDyO5pUSU6JRWK=
D-283MED MkHPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHzPRZlKSzVyPUOuNVg6OzdizszN MW\TRW5ITVJ?
COLO-800 NYjPeod1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmnMTWM2OD1|LkOzPFk4KM7:TR?= MVfTRW5ITVJ?
MFM-223 M3O1[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2D4PWlEPTB;Mz6zOlA6PyEQvF2= MmnBV2FPT0WU
TE-5 NYrsUGN6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NELYRlBKSzVyPUSuOVYyPDdizszN MmXjV2FPT0WU
NCI-H209 M3;2Smdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3LFWWlEPTB;ND63PFU4OiEQvF2= MkfaV2FPT0WU
SiHa NYXxO2NIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHvCTo5KSzVyPUSuPVUzODNizszN MVfTRW5ITVJ?
NCI-H1395 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnvwTWM2OD13LkGwOlM{KM7:TR?= MmLXV2FPT0WU
A498 MnjMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXvSPWpPUUN3ME21MlIyOjVzIN88US=> NHSxc2hUSU6JRWK=
ES5 MnPUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGG5TIxKSzVyPUWuOlEyPzhizszN M4DvWnNCVkeHUh?=
MDA-MB-157 M3y2[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYjxRW1wUUN3ME21MlY3PDR|IN88US=> MWPTRW5ITVJ?
NCI-H1623 Mnu4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlHHTWM2OD13LkizOVU3KM7:TR?= Ml\0V2FPT0WU
RPMI-8866 NYXrZYtGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkTTTWM2OD13Lki0O|kzKM7:TR?= MX7TRW5ITVJ?
LC-1F MoDuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGjhOVlKSzVyPU[uNFkzQTFizszN NH[5b5pUSU6JRWK=
TCCSUP MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NG[5dmFKSzVyPU[uOlA{PDlizszN MmfLV2FPT0WU
TT MlyzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX3UeZBMUUN3ME24MlM{ODB7IN88US=> MXzTRW5ITVJ?
NCI-H1838 NWjkdmRmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mo[zTWM2OD16LkWxO|MyKM7:TR?= MlTaV2FPT0WU
NCI-H322M M2nnc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUPEOmVpUUN3ME25MlE3OjhzIN88US=> MlHDV2FPT0WU
NCI-H187 MoD6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVPvZpV7UUN3ME25MlUyQDN3IN88US=> MlzrV2FPT0WU
SBC-1 NVjxbohXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUnkboRUUUN3ME25Mlk{PjV4IN88US=> MYLTRW5ITVJ?
SCC-3 MlHNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2j1U2lEPTB;MUCuOVY4QSEQvF2= M3jFV3NCVkeHUh?=
SW948 NUHvc3hRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlvMTWM2OD1zMD63OVEyKM7:TR?= M375XXNCVkeHUh?=
CPC-N NFvVZZZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml7CTWM2OD1zMT6wNFch|ryP Ml;5V2FPT0WU
TGBC24TKB M4TT[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mmq4TWM2OD1zMz61Nlkh|ryP NF;IZ|RUSU6JRWK=
NCI-H2452 NGLPW4JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEe5c4dKSzVyPUG0Mlc{KM7:TR?= Mn;3V2FPT0WU
Hs-578-T NETKdItIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYPXUHlQUUN3ME2xPE42PzV7IN88US=> M4DwenNCVkeHUh?=
DV-90 NH\4c3JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF:zb2pKSzVyPUG4Mlk6PDVizszN NIH3[XBUSU6JRWK=
NCI-H1563 NIjHW5VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MW\JR|UxRTF7Lke4PFgh|ryP NVvrdI9xW0GQR1XS
SW780 NYDRWFV7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVPJR|UxRTJzLkGzNVgh|ryP M3Txe3NCVkeHUh?=
NCI-H345 NYD1[IF6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUfUWGMxUUN3ME2yNU45Pzd7IN88US=> NV2yfmxvW0GQR1XS
LB771-HNC MlLOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV\JR|UxRTJ{LkS4NVMh|ryP NEjY[XBUSU6JRWK=
RT4 NGroZYJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXrJR|UxRTJ|LkOyPFIh|ryP NXHCcZhHW0GQR1XS
NCI-H82 NH\0WZNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXjJR|UxRTJ|LkW1NlYh|ryP MYXTRW5ITVJ?
NCI-H524 MmHQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX3JR|UxRTJ2LkO4NVIh|ryP MXTTRW5ITVJ?
SNU-C1 MnvRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEPrOlFKSzVyPUK0MlkyODVizszN NFvuTHpUSU6JRWK=
NCI-SNU-16 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVXJR|UxRTR6LkOxOFIh|ryP NXLER3JbW0GQR1XS

... Click to View More Cell Line Experimental Data

In vivo Treatment with NVP-AUY922 causes a robust antitumor response and inhibits p-Akt and VEGF expression in an HSC-2 xenograft model. [2] In BT474, NVP-AUY922 shows complete loss of ERBB2 and substantial depletion of ERα, in addition to reductions in CDK4 and phospho-ERK1/2. [3]

Protocol

Kinase Assay:[3]
+ Expand

Kinase assay:

NVP-AUY922 is dissolved in DMSO at a concentration of 10 mM. NVP-AUY922 is assessed against HSP90α, HSP90β, GRP94, TRAP-1, HSP72, and topoisomerase II. Profiling against a panel of kinases has been carried out and screening against a panel of additional enzymes and receptors is performed at Cerep.
Cell Research:[1]
+ Expand
  • Cell lines: Human gastric cancer cells NCI-N87
  • Concentrations: 1 μM
  • Incubation Time: 3 days
  • Method: Human gastric cancer cells NCI-N87 (5-7 ×103 in 50 μL/well) are seeded in 96-well plates and incubated at 37 °C for 24 hours, followed by NVP-AUY922 treatment for 1-3 days at 37 °C. After treatment, the cells are assayed by MTT method and analyzed by microplate reader.
    (Only for Reference)
Animal Research:[3]
+ Expand
  • Animal Models: Female NCr athymic mice bearing WM266.4 human melanoma xenografts
  • Formulation: In DMSO and diluted in sterile saline/Tween 20
  • Dosages: 50 mg/kg
  • Administration: Administered via i.v. or i.p.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 93 mg/mL warmed (199.76 mM)
Ethanol 31 mg/mL (66.58 mM)
Water Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
1% DMSO+30% polyethylene glycol+1% Tween 80
For best results, use promptly after mixing.
30 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 465.54
Formula

C26H31N3O5

CAS No. 747412-49-3
Storage powder
in solvent
Synonyms VER-52296

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

  • Mass
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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
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    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT01784640 Active, not recruiting Recurrent Non-small Cell Lung Cancer|Squamous Cell Lung Cancer|Stage IV Non-small Cell Lung Cancer Jonsson Comprehensive Cancer Center|National Cancer Institute (NCI) January 2014 Phase 1
NCT01922583 Active, not recruiting Non-small Cell Lung Cancer (NSCLC) National Taiwan University Hospital January 2014 Phase 2
NCT01854034 Active, not recruiting Non Small Cell Lung Cancer Massachusetts General Hospital July 2013 Phase 2
NCT01772797 Completed Anaplastic Lymphoma Kinase (ALK)|Non-small Cell Lung Cancer Novartis Pharmaceuticals|Novartis June 2013 Phase 1
NCT01752400 Active, not recruiting Non Small Cell Lung Cancer Massachusetts General Hospital January 2013 Phase 2
NCT01613950 Completed Stomach Neoplasms Esophageal Neoplasms Metastatic Gastric Cancer Mutated PI3KCA Protein Overexpressed HER2 Protein Novartis Pharmaceuticals|Novartis December 2012 Phase 1

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID