17-AAG (Tanespimycin)

Catalog No.S1141

17-AAG (Tanespimycin) is a potent HSP90 inhibitor with IC50 of 5 nM in a cell-free assay, having a 100-fold higher binding affinity for HSP90 derived from tumour cells than HSP90 from normal cells. Phase 2.

Price Stock Quantity  
USD 195 In stock
USD 150 In stock
USD 370 In stock
Bulk Inquiry

Massive Discount Available

Free Overnight Delivery on all orders over $ 500.

17-AAG (Tanespimycin) Chemical Structure

17-AAG (Tanespimycin) Chemical Structure
Molecular Weight: 585.69

Validation & Quality Control

7 customer reviews :

Quality Control & MSDS

Related Compound Libraries

17-AAG (Tanespimycin) is available in the following compound libraries:

HSP (e.g. HSP90) Inhibitors with Unique Features

  • Selective HSP90 Inhibitor

    NVP-BEP800 HSP90β-selective, IC50=58 nM.

  • Most Potent HSP90 Inhibitor

    KW-2478 HSP90, IC50=3.8 nM.

  • HSP90 Inhibitor in Clinical Trial

    17-DMAG (Alvespimycin) HCl Phase II for Kidney Cancer.

  • Newest HSP90 Inhibitor

    XL888 ATP-competitive inhibitor of HSP90 with IC50 of 24 nM.

Product Information

  • Compare HSP (e.g. HSP90) Inhibitors
    Compare HSP (e.g. HSP90) Products
  • Research Area

Product Description

Biological Activity

Description 17-AAG (Tanespimycin) is a potent HSP90 inhibitor with IC50 of 5 nM in a cell-free assay, having a 100-fold higher binding affinity for HSP90 derived from tumour cells than HSP90 from normal cells. Phase 2.
Targets HSP90 [1]
(Cell-free assay)
IC50 5 nM
In vitro 17-AAG, an analog of geldanamycin, exhibits greater than 100 times higher binding affinity for Hsp90 derived from HER-2-overexpressing cancer cells (BT474, N87, SKOV3 and SKBR3) or BT474 breast carcinoma cells with IC50 values of 5-6 nM. [1] 17-AAG causes the degradation of HER2, HER3, Akt, and both mutant and wild-type androgen receptor (AR), leading to the RB-dependent G1 growth arrest of prostate cancer cells such as LNCaP, LAPC-4, DU-145, and PC-3 with IC50 values of 25-45 nM. [2] In addition to inducing apoptosis of Ba/F3 cells transformed with wild-type BCR-ABL with an IC50 of 5.2 μM, 17-AAG has the ability to induce apoptosis of cells transformed with imatinib mesylate-resistant T315I and E255K BCR-ABL mutants with IC50 values of 2.3 μM and 1.0 μM, respectively, by inducing the degradation of both wild-type BCR-ABL protein and mutants. [3]
Cell Data
Cell LinesAssay TypeConcentrationIncubation TimeFormulationActivity DescriptionPMID
A549NW\jVFBKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M4fTPWlEPTB;MD6wNFA{ODNizszNM3vaRnNCVkeHUh?=
IST-MEL1NVfSWpdzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M{G1fGlEPTB;MD6wNFA1ODdizszNMWjTRW5ITVJ?
NCI-SNU-1NGjZbJFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MmjFTWM2OD1yLkCwNlA4KM7:TR?=NHvwVmtUSU6JRWK=
FADUNHm1V4tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NXPC[o1yUUN3ME2wMlAxOjB7IN88US=>NYTxUodUW0GQR1XS
C32MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MnjHTWM2OD1yLkCwN|A1KM7:TR?=M4noSnNCVkeHUh?=
D-566MGMl7qS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MXXJR|UxRTBwMECzPUDPxE1?NUDLfIJ6W0GQR1XS
LXF-289MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M4DwOGlEPTB;MD6wNFQyQSEQvF2=M3vIbXNCVkeHUh?=
HGC-27M2C1WGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NYL2c41pUUN3ME2wMlAxPTFizszNM{m3cHNCVkeHUh?=
RPMI-7951M1rmN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7NF\GcXpKSzVyPUCuNFA4OTdizszNM2\wSnNCVkeHUh?=
HSC-3M{DjXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MWjJR|UxRTBwMEC5Nlkh|ryPNGTvfJZUSU6JRWK=
MIA-PaCa-2M2X0dmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M1:1[GlEPTB;MD6wNVAxQSEQvF2=NUG5XZNSW0GQR1XS
KS-1NHTlbo5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NX30[GFzUUN3ME2wMlAyOzV3IN88US=>NVHub2xCW0GQR1XS
CAL-51MmrMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MmO1TWM2OD1yLkCxOFA2KM7:TR?=NGHFR4JUSU6JRWK=
MDA-MB-361MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NYnD[npXUUN3ME2wMlAyPDl3IN88US=>MnfYV2FPT0WU
TI-73MmTDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NVfRZndIUUN3ME2wMlAyPzl4IN88US=>MmfQV2FPT0WU
AGSNWXhZ2IxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MWPJR|UxRTBwMEG5N|gh|ryPM1T4RXNCVkeHUh?=
NCI-H460Ml7WS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MWHJR|UxRTBwMEG5O|Qh|ryPNFz4eppUSU6JRWK=
A204M1LmSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MlHRTWM2OD1yLkCyNlQ6KM7:TR?=MorvV2FPT0WU
CHL-1NX7pNop{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NVGzWZdDUUN3ME2wMlAzOjVzIN88US=>M3zUTHNCVkeHUh?=
DU-4475NWO1Spk2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M{Tj[2lEPTB;MD6wNlI3OSEQvF2=MVXTRW5ITVJ?
CGTH-W-1M1;5U2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7M4nRNmlEPTB;MD6wNlM1QSEQvF2=NHT3[ZNUSU6JRWK=
HCC2218NEDrOJhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MmfXTWM2OD1yLkCyOFk1KM7:TR?=MlX5V2FPT0WU
A2780NUfZPHRLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M4jXTGlEPTB;MD6wNlU{OSEQvF2=M3TKd3NCVkeHUh?=
NCI-H720NWTBSGVzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M1Gy[GlEPTB;MD6wNlU1PiEQvF2=Mo\SV2FPT0WU
NCI-N87NX\nZY4xT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=Mmn6TWM2OD1yLkCyOVk{KM7:TR?=Mlm5V2FPT0WU
CHP-212MoiwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MYTJR|UxRTBwMEK2Nlgh|ryPM333VnNCVkeHUh?=
NCI-H23NF;BUWpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NX36[JpZUUN3ME2wMlAzPjZ3IN88US=>M{j0eXNCVkeHUh?=
D-263MGM4fKWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NGPzZohKSzVyPUCuNFI4QDZizszNMn6yV2FPT0WU
ME-180MkjoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MWfJR|UxRTBwMEK4PVEh|ryPNHvsUGxUSU6JRWK=
SW982MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NUjlNXN2UUN3ME2wMlAzQTl7IN88US=>MV3TRW5ITVJ?
OE19MlvmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M{DGV2lEPTB;MD6wN|A4PyEQvF2=M3[wXHNCVkeHUh?=
SK-LU-1MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M2DtZWlEPTB;MD6wN|A5OiEQvF2=NVLnWHZUW0GQR1XS
H4NUfFfW1{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NUPoZlFMUUN3ME2wMlA{ODlizszNNFXqb4NUSU6JRWK=
HT-144MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MnvITWM2OD1yLkCzNFk{KM7:TR?=NUnPR2FHW0GQR1XS
SK-UT-1MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MWnJR|UxRTBwMEOxO|gh|ryPM2rzTHNCVkeHUh?=
D-336MGMUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NFT6UlZKSzVyPUCuNFM{ODlizszNMVnTRW5ITVJ?
MDA-MB-175-VIIM16wemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7Mof2TWM2OD1yLkCzN|U1KM7:TR?=MYnTRW5ITVJ?
GAMGMnvqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NI\3cZdKSzVyPUCuNFM1OzVizszNNUXSNJJWW0GQR1XS
CP50-MEL-BMWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M{\Z[mlEPTB;MD6wN|Q2KM7:TR?=M1fMdXNCVkeHUh?=
OVCAR-5NH:1cohIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M3HqdGlEPTB;MD6wN|Q5KM7:TR?=NITUW25USU6JRWK=
SK-MES-1NXHnPZVOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M{nIdGlEPTB;MD6wN|YxPiEQvF2=NVq1Vm9iW0GQR1XS
VM-CUB-1NWDjPFNkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MXnJR|UxRTBwMEO2OVch|ryPNYnPcWw2W0GQR1XS
WM-115NWLEZ25mT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M{XOR2lEPTB;MD6wN|c3OiEQvF2=NILFSmZUSU6JRWK=
DSH1NVnrRZk2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MYnJR|UxRTBwMEO4NFch|ryPMkTUV2FPT0WU
BeckerNIfET2tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M{SzfmlEPTB;MD6wN|g5PSEQvF2=MnT6V2FPT0WU
SW962NYTnbotIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NXzBO2N2UUN3ME2wMlA{QTR3IN88US=>MYDTRW5ITVJ?
TYK-nuMlfNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?Ml\KTWM2OD1yLkCzPVg2KM7:TR?=NWD4O41DW0GQR1XS
HO-1-N-1M3ftSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M2\mZWlEPTB;MD6wOFAzOSEQvF2=Mn7ZV2FPT0WU
T98GM121[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7MmW4TWM2OD1yLkC0NVA{KM7:TR?=Mn74V2FPT0WU
ACNMV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NVv1OlZSUUN3ME2wMlA1OTZ{IN88US=>M3:xbXNCVkeHUh?=
SW780NU\pfZlVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M37KemlEPTB;MD6wOFIxOyEQvF2=NU\qdFlLW0GQR1XS
Detroit562MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M4fRdWlEPTB;MD6wOFI{QSEQvF2=NUjCOVdEW0GQR1XS
BB49-HNCMln0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NIXGTIhKSzVyPUCuNFQzPDNizszNNGTnPWNUSU6JRWK=
HNMnPRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M1jBO2lEPTB;MD6wOFI4OiEQvF2=MWPTRW5ITVJ?
H9MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MXjJR|UxRTBwMESzO|Eh|ryPM4PRV3NCVkeHUh?=
VA-ES-BJM2r5emdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MXrJR|UxRTBwMES0OFch|ryPMor0V2FPT0WU
MEL-JUSOMofCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NYPm[XRsUUN3ME2wMlA1PDd3IN88US=>Mn;4V2FPT0WU
BT-474NIP4OYJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NFnjephKSzVyPUCuNFQ2KM7:TR?=MlPtV2FPT0WU
CaR-1NGHBW|VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M2\GZWlEPTB;MD6wOFU1QSEQvF2=MWDTRW5ITVJ?
PSN1NVL3TplCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NV2yXo5qUUN3ME2wMlA1PjB|IN88US=>NUKyeZNqW0GQR1XS
KYSE-510MnPQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NXzldI1PUUN3ME2wMlA1PjR7IN88US=>NUD6VotlW0GQR1XS
KP-4MlPMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NFXhVpVKSzVyPUCuNFQ4PTNizszNNXf2R2l3W0GQR1XS
KYSE-410MojLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?Ml;XTWM2OD1yLkC0O|czKM7:TR?=MXnTRW5ITVJ?
G-402M{DUSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M2Lm[WlEPTB;MD6wOFc5QSEQvF2=NXPhW3p3W0GQR1XS
DOKMn34S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M2nWd2lEPTB;MD6wOFkxOiEQvF2=NWH1c4VlW0GQR1XS
COR-L88MnPSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MkHGTWM2OD1yLkC0PVEzKM7:TR?=MVfTRW5ITVJ?
SKG-IIIaMl3aS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NEiwRotKSzVyPUCuNFQ6QDZizszNMoT4V2FPT0WU
AN3-CAMn3MS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MlrwTWM2OD1yLkC1JO69VQ>?MmW3V2FPT0WU
SW48NWLxO3N[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NFPGZXNKSzVyPUCuNFUxOzlizszNMXXTRW5ITVJ?
YKG-1M3H3Nmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NFLPN2FKSzVyPUCuNFUxPzFizszNNUL5U3VQW0GQR1XS
KYSE-150NHvRfpRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NGL1cmhKSzVyPUCuNFUzOzVizszNM1O3VXNCVkeHUh?=
HuO-3N1MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NVfsSGI5UUN3ME2wMlA2OjN5IN88US=>Ml7oV2FPT0WU
LB1047-RCCNHO2TJpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MmDzTWM2OD1yLkC1Nlk3KM7:TR?=MWnTRW5ITVJ?
NCI-H2030MmnSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MVLJR|UxRTBwMEW0NVQh|ryPNFraOolUSU6JRWK=
YH-13NV64TmFWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NWPXeYg5UUN3ME2wMlA2PzJ{IN88US=>NWjtTWo3W0GQR1XS
5637M2W2PWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MXnJR|UxRTBwMEW3OEDPxE1?NHfhS|RUSU6JRWK=
LOXIMVIMXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MY\JR|UxRTBwMEW4O|Ih|ryPNXW4enZQW0GQR1XS
GT3TKBM33CRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MnK0TWM2OD1yLkC1PVQzKM7:TR?=M4DnUXNCVkeHUh?=
TCCSUPNETFc3NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=Mk[yTWM2OD1yLkC1PVY1KM7:TR?=M1qxUXNCVkeHUh?=
EPLC-272HM17Hd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7MUXJR|UxRTBwME[yNFUh|ryPM4jCPXNCVkeHUh?=
LU-99AM1HyTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NUn4W21UUUN3ME2wMlA3OjN5IN88US=>NFz4UoVUSU6JRWK=
NCI-H1755NFzT[mpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NWPMd4xuUUN3ME2wMlA3OzRzIN88US=>NGD4R21USU6JRWK=
KM12M{TodWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NIGw[GZKSzVyPUCuNFY{PDhizszNM{K0RnNCVkeHUh?=
SF295NFG1NYtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MWnJR|UxRTBwME[0OVIh|ryPMlvwV2FPT0WU
MZ2-MELNFXLd|dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MlHqTWM2OD1yLkC2OVU{KM7:TR?=NEXpTFlUSU6JRWK=
HEC-1MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NXnOVWlrUUN3ME2wMlA3PTh6IN88US=>NVXW[3ZHW0GQR1XS
SW684M4Lybmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NVvyWoppUUN3ME2wMlA3PTlzIN88US=>NX3uOWpPW0GQR1XS
SF539MmnDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MojhTWM2OD1yLkC2OlgyKM7:TR?=NX7scpRXW0GQR1XS
GMS-10MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NF7ycWJKSzVyPUCuNFY3QTlizszNNEfPdo1USU6JRWK=
MV-4-11NXLyPXlMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NXjFbVE5UUN3ME2wMlA3QDB|IN88US=>NITRS2RUSU6JRWK=
HT-29Mkn3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NVP1ZY5tUUN3ME2wMlA3QTF7IN88US=>NUf4ZmhHW0GQR1XS
23132-87MlTYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NGnRV2tKSzVyPUCuNFY6PSEQvF2=NF25W2lUSU6JRWK=
SW620MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MUnJR|UxRTBwMEewNlYh|ryPMVXTRW5ITVJ?
HCC1806MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MW\JR|UxRTBwMEexN|Eh|ryPNXTVRWdqW0GQR1XS
Hs-578-TNFjNc2tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NV7aRm85UUN3ME2wMlA4OjB6IN88US=>M{jBVnNCVkeHUh?=
A2058NV\hNod4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NWDqeI91UUN3ME2wMlA4OjJ6IN88US=>MoPkV2FPT0WU
MEL-HONGDpcZlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MXXJR|UxRTBwMEeyOVUh|ryPNXzWWpY5W0GQR1XS
HCC2998MonaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NWf6NnZmUUN3ME2wMlA4OzR5IN88US=>NYjLdpJxW0GQR1XS
HuO9NXvUVZozT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MWPJR|UxRTBwMEe1PFkh|ryPMkP4V2FPT0WU
CAL-39MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?Ml\oTWM2OD1yLkC3O|Y3KM7:TR?=NG\VcIpUSU6JRWK=
M14MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NGTDRmRKSzVyPUCuNFc6OTNizszNNG[1[GtUSU6JRWK=
BFTC-909MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MYHJR|UxRTBwMEe5Olkh|ryPNWPDc2xzW0GQR1XS
TE-11M1qwVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M3e5NWlEPTB;MD6wO|k6PiEQvF2=M1zE[HNCVkeHUh?=
TGBC1TKBM3;FUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MWnJR|UxRTBwMEiwOFMh|ryPNULUO4tvW0GQR1XS
L-363NV3FU|c{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MV3JR|UxRTBwMEiyNFYh|ryPMX7TRW5ITVJ?
A431M4j6UWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MYrJR|UxRTBwMEiyNUDPxE1?MYXTRW5ITVJ?
MKN45NUnNZoxZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NEnKfpRKSzVyPUCuNFgzOTlizszNM2qwcXNCVkeHUh?=
HT-1080MlrsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NELsWWhKSzVyPUCuNFg1OzlizszNMk\mV2FPT0WU
OVCAR-8MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MnewTWM2OD1yLkC4OlIzKM7:TR?=MWfTRW5ITVJ?
LCLC-97TM1NXjxe4U{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M1n1N2lEPTB;MD6wPFczQCEQvF2=NVTvenlpW0GQR1XS
M059JNV\QOWpPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NVTHV5hrUUN3ME2wMlA6ODJ5IN88US=>MWfTRW5ITVJ?
SK-MEL-2NYCyTI5ST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MnXlTWM2OD1yLkC5NFYh|ryPM3zpN3NCVkeHUh?=
TE-1MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MWHJR|UxRTBwMEmyNFQh|ryPNFPzeXNUSU6JRWK=
KYSE-180M4HDZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NF3ydZhKSzVyPUCuNFkzPjJizszNM1zZ[3NCVkeHUh?=
D-247MGMonwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NX3teoJHUUN3ME2wMlA6PDV3IN88US=>M1y4bHNCVkeHUh?=
8-MG-BANGHCSWZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NXWycFVbUUN3ME2wMlA6PDd{IN88US=>MV\TRW5ITVJ?
NCI-H1792NUWy[2p7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NEnWSm9KSzVyPUCuNFk3OThizszNM33uVnNCVkeHUh?=
MCF7M2\LT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7NFXkN3dKSzVyPUCuNFk3PzdizszNNX\1bGdIW0GQR1XS
NCI-H2122NUf0SXZmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NVm0R41SUUN3ME2wMlA6PzR3IN88US=>M2K1cnNCVkeHUh?=
EFO-27NWfwOmc4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M1LycmlEPTB;MD6wPVk6PyEQvF2=NHfrWFBUSU6JRWK=
LB2241-RCCNFe2dHZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NF60O5RKSzVyPUCuNVAxPTRizszNM3T3O3NCVkeHUh?=
SN12CNHzyPIFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MUHJR|UxRTBwMUCxNFch|ryPMkLJV2FPT0WU
A498MoHES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MWHJR|UxRTBwMUCxPEDPxE1?M4\nXHNCVkeHUh?=
PANC-03-27NIrVdGtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MUjJR|UxRTBwMUCyPFYh|ryPM2fYSHNCVkeHUh?=
NCI-H1581NF;uW29Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MUjJR|UxRTBwMUCyPUDPxE1?MmDUV2FPT0WU
U-87-MGNGCzPIZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MVrJR|UxRTBwMUCzNFch|ryPNGOzW2RUSU6JRWK=
G-401MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MYrJR|UxRTBwMUCzOVMh|ryPNHnVe|VUSU6JRWK=
SiHaMl;lS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?Mn61TWM2OD1yLkGwOFg3KM7:TR?=NGLz[pVUSU6JRWK=
U251NGjnT|NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NFf5WpVKSzVyPUCuNVA2OjVizszNNFfVcZNUSU6JRWK=
MMAC-SFNFGyeZhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NU\OcW9VUUN3ME2wMlExPTNzIN88US=>NWTBUZVtW0GQR1XS
BB65-RCCM37kV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7MoHTTWM2OD1yLkGwOVU1KM7:TR?=NYj3WpJEW0GQR1XS
NKM-1NGLDcWpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MljXTWM2OD1yLkGwOlY3KM7:TR?=MmP1V2FPT0WU
HD-MY-ZMnfjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NX;4d4hVUUN3ME2wMlExQDd|IN88US=>NFzkRVNUSU6JRWK=
TGBC11TKBM{\pZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MUXJR|UxRTBwMUC5NFMh|ryPMW\TRW5ITVJ?
COLO-679MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M2PKS2lEPTB;MD6xNVIyOSEQvF2=M1W4SXNCVkeHUh?=
TE-8NYLYN2NWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NHKy[2NKSzVyPUCuNVEzPjRizszNMYjTRW5ITVJ?
SK-MEL-28MnzLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NVn0d2ljUUN3ME2wMlEyOzJzIN88US=>NWLXXGNbW0GQR1XS
SH-4NX;ROVBsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M1Ll[2lEPTB;MD6xNVM2PiEQvF2=NGntd5FUSU6JRWK=
KALS-1M2\LcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M4jXXmlEPTB;MD6xNVM6OyEQvF2=NVj5SZJxW0GQR1XS
RKONVvKbm8zT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M2LYPWlEPTB;MD6xNVc3PCEQvF2=M3TyTHNCVkeHUh?=
OMC-1M3;Pfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7Mk[2TWM2OD1yLkGxO|k4KM7:TR?=MWjTRW5ITVJ?
BT-549NIrwNWVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MmfRTWM2OD1yLkGxO|k6KM7:TR?=NGTsXYVUSU6JRWK=
NCI-H28MlzSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MXLJR|UxRTBwMUG4NVch|ryPNXzGcWc{W0GQR1XS
RXF393NF7TS5FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MVnJR|UxRTBwMUG5PFIh|ryPNXH2V5JCW0GQR1XS
COLO-829MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MXjJR|UxRTBwMUKwNFUh|ryPNFvzTpJUSU6JRWK=
HMV-IIMl7ZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M17EcmlEPTB;MD6xNlAzKM7:TR?=Mmm5V2FPT0WU
SW1990MkS0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NUm0SmVvUUN3ME2wMlEzOTV5IN88US=>NFHWRppUSU6JRWK=
NCI-H1437MkLGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NYrtW5ZSUUN3ME2wMlEzOTV5IN88US=>NY[3dJU1W0GQR1XS
SNB75NX7aNXFlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MX\JR|UxRTBwMUKxOlkh|ryPMoLrV2FPT0WU
EW-3M2nlOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NHvOXIlKSzVyPUCuNVI3PjFizszNMlr4V2FPT0WU
SASMYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MVTJR|UxRTBwMUK2PUDPxE1?M2G0cHNCVkeHUh?=
NCI-H1666NEPmfVBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NV3XWlRNUUN3ME2wMlEzPzd2IN88US=>NFfTfW5USU6JRWK=
A375MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MUnJR|UxRTBwMUK3O|gh|ryPNVnDeJZVW0GQR1XS
CAMA-1MojiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NH;qfpZKSzVyPUCuNVI6OjRizszNNUPXcZpCW0GQR1XS
HuP-T4NGfRRWRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MXzJR|UxRTBwMUK5OFMh|ryPMkPOV2FPT0WU
NCI-H292M3\1N2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7NFXDT29KSzVyPUCuNVMyOSEQvF2=M{S4PHNCVkeHUh?=
PC-14M{HBRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MX3JR|UxRTBwMUOyNVEh|ryPM1XvXnNCVkeHUh?=
BPH-1MlTlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NXnt[FlmUUN3ME2wMlE{PDFizszNNFvHW3JUSU6JRWK=
GAKM{HsZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MnezTWM2OD1yLkGzOVY4KM7:TR?=Ml21V2FPT0WU
VMRC-RCZMnfXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NVLr[ZdbUUN3ME2wMlE{PzZ{IN88US=>NXTR[pR2W0GQR1XS
SK-MEL-24NEGwNWdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MXLJR|UxRTBwMUO4O{DPxE1?NXjXV5hDW0GQR1XS
LB831-BLCMV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M3XOUWlEPTB;MD6xN|g5OyEQvF2=NFfPXG9USU6JRWK=
NCI-H2452NH3ZR25Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NW\ZfFdKUUN3ME2wMlE{QTV4IN88US=>NWn4em85W0GQR1XS
RT-112M{PkXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NVLMTnRWUUN3ME2wMlE1ODN3IN88US=>NYnNOFVqW0GQR1XS
GP5dMli1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NX:wO2g1UUN3ME2wMlE1OTB2IN88US=>NFPr[mpUSU6JRWK=
LC-2-adNEnNPYJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M1TnemlEPTB;MD6xOFEzOSEQvF2=M1T0S3NCVkeHUh?=
MPP-89MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M2jU[mlEPTB;MD6xOFEzPSEQvF2=MVTTRW5ITVJ?
NUGC-3NVfZcGpHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NVi4NIpLUUN3ME2wMlE1PDd6IN88US=>MXTTRW5ITVJ?
GI-1NVHOVnhnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MWPJR|UxRTBwMUS1OVgh|ryPNV:2OmdQW0GQR1XS
HCC1419MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MXHJR|UxRTBwMUS1O|Yh|ryPM1mxbXNCVkeHUh?=
SW1573NHfhSm1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MWjJR|UxRTBwMUS3OVgh|ryPMXnTRW5ITVJ?
NCI-H2347NHXqfolIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M2j3V2lEPTB;MD6xOFg{QSEQvF2=Mln2V2FPT0WU
MewoMWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NX7Qc3JpUUN3ME2wMlE1QDh7IN88US=>NXvUTnpRW0GQR1XS
639-VNHrKT2lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MVXJR|UxRTBwMUWwNVMh|ryPMkLGV2FPT0WU
AsPC-1NUPvT3R[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NYnRe2FyUUN3ME2wMlE2OjJ3IN88US=>NXPFZ5psW0GQR1XS
NCI-H1648NYK2e3dmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NGjNcXVKSzVyPUCuNVUzOzJizszNNVmwXlJ5W0GQR1XS
786-0NWDa[VJXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NYnNbmFiUUN3ME2wMlE2OzhzIN88US=>NH[0doxUSU6JRWK=
ETK-1NIPIXIlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M4fmTmlEPTB;MD6xOVkh|ryPNITX[XpUSU6JRWK=
BxPC-3MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MmmwTWM2OD1yLkG1PVY3KM7:TR?=NVq4SG1VW0GQR1XS
CAL-62NITOeFJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M37HTmlEPTB;MD6xOlE3QSEQvF2=NUjYZXdrW0GQR1XS
HCC1937NUTJOYJoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NXLLN|VnUUN3ME2wMlE3Ojd3IN88US=>MXzTRW5ITVJ?
NCI-H1299NUPRTGZ3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MV3JR|UxRTBwMU[yPFUh|ryPMYnTRW5ITVJ?
SW1088NUDUXY9GT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M1PCc2lEPTB;MD6xOlQyOyEQvF2=NHHyT5NUSU6JRWK=
FTC-133MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NF;Bd3NKSzVyPUCuNVY2PCEQvF2=NILrTlhUSU6JRWK=
OC-314MknFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M{Tre2lEPTB;MD6xOlY6KM7:TR?=NXXGe29qW0GQR1XS
SCC-9M1;IUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MYfJR|UxRTBwMU[3NVYh|ryPMljTV2FPT0WU
HT-1376MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NInLc2JKSzVyPUCuNVY6OzZizszNMljqV2FPT0WU
U-2-OSNVTibWVQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MkW1TWM2OD1yLkG3NVc{KM7:TR?=NIjwXoxUSU6JRWK=
COLO-824NFHSZXlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NIP2OHNKSzVyPUCuNVczQTRizszNNH\pUlZUSU6JRWK=
BB30-HNCMV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MUfJR|UxRTBwMUezN{DPxE1?MXTTRW5ITVJ?
NCI-H2087MofiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?Mmi3TWM2OD1yLkG3N|Y5KM7:TR?=MoftV2FPT0WU
NCI-H2170NF:2O4RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M130XWlEPTB;MD6xO|U{PiEQvF2=MV7TRW5ITVJ?
SK-OV-3NHfQdYFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M1Tic2lEPTB;MD6xO|U4OSEQvF2=MUTTRW5ITVJ?
MZ7-melNEXjepRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M2TiWWlEPTB;MD6xO|Y1QSEQvF2=MUfTRW5ITVJ?
NCI-H650NFTXVWtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MnTzTWM2OD1yLkG3OlgzKM7:TR?=MXjTRW5ITVJ?
KOSC-2NHThT29Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NH:xZohKSzVyPUCuNVc4OzRizszNNGDNOGNUSU6JRWK=
SCC-4MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MWLJR|UxRTBwMUe3O|ch|ryPM{na[nNCVkeHUh?=
MDA-MB-157M4qxUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MUjJR|UxRTBwMUiwPFIh|ryPNUDYe5Y3W0GQR1XS
KYSE-520MmrRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M4DXZWlEPTB;MD6xPFIh|ryPM1;hNnNCVkeHUh?=
LK-2NUnvXW1uT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NI\WT2ZKSzVyPUCuNVg{ODNizszNMkfBV2FPT0WU
KNS-81-FDNWW2bWdLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M{G1RWlEPTB;MD6xPFM6PCEQvF2=MVvTRW5ITVJ?
IGROV-1M1nOZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7NIDybW9KSzVyPUCuNVg1PDNizszNMn\VV2FPT0WU
DELMYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NEfIXWVKSzVyPUCuNVg1PSEQvF2=MnT6V2FPT0WU
NCI-H1395MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NYjZVXdlUUN3ME2wMlE5Pjh{IN88US=>M1rNNnNCVkeHUh?=
JEG-3MoHQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MWXJR|UxRTBwMUi3NFUh|ryPMXPTRW5ITVJ?
BCPAPNF7BeFRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MlTrTWM2OD1yLkG4PFczKM7:TR?=MljJV2FPT0WU
CAL-27MnLuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NWL6XoV6UUN3ME2wMlE6ODJ{IN88US=>M3LaUHNCVkeHUh?=
RDM1z5dWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NETCVHBKSzVyPUCuNVkyOTNizszNMXLTRW5ITVJ?
RVH-421NWLBZWxWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MVXJR|UxRTBwMUmxNVYh|ryPM160SnNCVkeHUh?=
Capan-2MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?Mn\NTWM2OD1yLkG5NlU3KM7:TR?=NEDaS4FUSU6JRWK=
COLO-680NNHTWTGdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NIfvRphKSzVyPUCuNVk{PjRizszNMoTaV2FPT0WU
NCI-H1650NXLSb5lnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MX3JR|UxRTBwMkCwOVch|ryPNF:4PWxUSU6JRWK=
SBC-5M13BRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NWfl[5ZsUUN3ME2wMlIxOTF6IN88US=>M{jqSXNCVkeHUh?=
U031NUT3cWwzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MUXJR|UxRTBwMkC1OFch|ryPNIHSUoZUSU6JRWK=
S-117MlHGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NVXkfZFGUUN3ME2wMlIxPTZ2IN88US=>M3noUHNCVkeHUh?=
DoTc2-4510M3jPOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7Mnf5TWM2OD1yLkKwO|Y6KM7:TR?=NEH5V3pUSU6JRWK=
AM-38M2TEeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MlHhTWM2OD1yLkKwPFQ5KM7:TR?=NVTaZ2l{W0GQR1XS
A172MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M3\Xc2lEPTB;MD6yNVAzOiEQvF2=M2\kWHNCVkeHUh?=
HPAF-IINX\mWXJQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NWLkNnRUUUN3ME2wMlIyOjZ2IN88US=>NEPTTXZUSU6JRWK=
769-PM1XjT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7NVS1OI5jUUN3ME2wMlIyOjhizszNMnXlV2FPT0WU
MFE-280MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NGfXcodKSzVyPUCuNlEzQThizszNNEnVS3RUSU6JRWK=
TE-9NFPPXWZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M4nRcmlEPTB;MD6yNVc5PiEQvF2=MUHTRW5ITVJ?
C2BBe1MkWwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MojzTWM2OD1yLkKyNVkh|ryPMnXKV2FPT0WU
EoL-1-cellNI[2dJNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MnvwTWM2OD1yLkKyNlA{KM7:TR?=M4LXVHNCVkeHUh?=
G-361M3:0XGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NVvtTlR[UUN3ME2wMlIzPjh{IN88US=>MoTsV2FPT0WU
KYSE-270MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M3PHbGlEPTB;MD6yN|A5PCEQvF2=NV:0SpkxW0GQR1XS
TK10Ml3FS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MmjuTWM2OD1yLkKzNVE4KM7:TR?=MULTRW5ITVJ?
ML-2MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MUjJR|UxRTBwMkOxNVkh|ryPNHz3WVdUSU6JRWK=
MHH-ES-1MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NWn2dVVwUUN3ME2wMlI{PjhzIN88US=>NGPFSY9USU6JRWK=
BHYM3nVc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7NIHWfJpKSzVyPUCuNlM3QTFizszNMV\TRW5ITVJ?
LS-513M3vob2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7NITYV4RKSzVyPUCuNlM6PjFizszNM3K2S3NCVkeHUh?=
COLO-678MoDNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NUTWeZVDUUN3ME2wMlI1ODR2IN88US=>MUTTRW5ITVJ?
NCI-H747M4PqTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MkPZTWM2OD1yLkK0NVY6KM7:TR?=NF3ubWRUSU6JRWK=
K5MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NF70bmlKSzVyPUCuNlQ{QCEQvF2=M{\T[3NCVkeHUh?=
OS-RC-2MmfCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MV7JR|UxRTBwMkS1NFkh|ryPMUPTRW5ITVJ?
KINGS-1MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M2fSSmlEPTB;MD6yOFUzQSEQvF2=M4HidHNCVkeHUh?=
SCC-25M3TkVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NV3OSGUyUUN3ME2wMlI1PTZ|IN88US=>NU\EbodRW0GQR1XS
CAPAN-1NX3JbZI3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MXHJR|UxRTBwMkS3PFMh|ryPNXjWT3p7W0GQR1XS
ESS-1MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NUPUeWNNUUN3ME2wMlI1QDB3IN88US=>NEGwb4tUSU6JRWK=
TE-6MmG4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MXHJR|UxRTBwMkW3OUDPxE1?NETlR4tUSU6JRWK=
LB2518-MELMlHKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NETzXItKSzVyPUCuNlU4PzdizszNNUnNZ|JUW0GQR1XS
COLO-800NWDGbmdQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MlHaTWM2OD1yLkK1PFEzKM7:TR?=NUDHeIUxW0GQR1XS
LU-134-ANH3nN5dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M4P1PGlEPTB;MD6yOlE{PiEQvF2=MVPTRW5ITVJ?
NCI-H1155M1flXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NVf0UWdTUUN3ME2wMlI3OTZ{IN88US=>NX;UVZNbW0GQR1XS
MFM-223NFPIVmFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M2eyPGlEPTB;MD6yOlM3OyEQvF2=NETGOItUSU6JRWK=
HTC-C3MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M1XjOmlEPTB;MD6yOlUxPiEQvF2=NVPmS5dYW0GQR1XS
HCT-116MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?Mki4TWM2OD1yLkK2OVk6KM7:TR?=NGOwWFlUSU6JRWK=
Ca-SkiMXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NUPZ[IY6UUN3ME2wMlI3Pjd6IN88US=>MWrTRW5ITVJ?
SBC-1NGfZd5dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MlXaTWM2OD1yLkK2O|QzKM7:TR?=NXy5NWVpW0GQR1XS
NB69NYfWZ5hLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MmDWTWM2OD1yLkK3NFg4KM7:TR?=M3vvUHNCVkeHUh?=
J82MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NIjHb2FKSzVyPUCuNlczPjVizszNNV3LZZV5W0GQR1XS
U-118-MGM2nVW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7MkS3TWM2OD1yLkK3OVc6KM7:TR?=NVG1[nliW0GQR1XS
NCI-H1355NV6yXYJrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NYPENmJFUUN3ME2wMlI5ODd2IN88US=>NH\K[HBUSU6JRWK=
NCI-H1048NHPzTYNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M2\zemlEPTB;MD6yPFk2PiEQvF2=NVe5TlExW0GQR1XS
SW954NVv4XnZNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NHrkbWFKSzVyPUCuNlkzOjdizszNM1jxOHNCVkeHUh?=
NMC-G1NUX5VHRmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MmnhTWM2OD1yLkK5Nlc4KM7:TR?=M1:5bHNCVkeHUh?=
SW1710NHTpcm5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NFzrZpVKSzVyPUCuNlk1QTRizszNNXfPb2o{W0GQR1XS
KY821NWn5boxKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NFvGb|JKSzVyPUCuNlk5PzJizszNMoDoV2FPT0WU
HCC38MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MWXJR|UxRTBwM{CwO|gh|ryPM4Hub3NCVkeHUh?=
NCI-SNU-5M3\sbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M1vSd2lEPTB;MD6zNFU1KM7:TR?=NGjHU|ZUSU6JRWK=
ES8MomwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MkDITWM2OD1yLkOwO|g1KM7:TR?=NH7TdIRUSU6JRWK=
COLO-792NGr0TIRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MULJR|UxRTBwM{GyOVEh|ryPMoLGV2FPT0WU
BFTC-905M1jPbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MXLJR|UxRTBwM{G1NlEh|ryPM1XsW3NCVkeHUh?=
ChaGo-K-1NIixWolIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MnG3TWM2OD1yLkOxO|E2KM7:TR?=NGHmUINUSU6JRWK=
DaoyMVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MlrRTWM2OD1yLkOxO|I{KM7:TR?=MoSwV2FPT0WU
SJSA-1M4[2eGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NUn4SYNOUUN3ME2wMlMyQDR5IN88US=>MlewV2FPT0WU
KNS-62MljCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NUG4fW12UUN3ME2wMlMzODh6IN88US=>MkXXV2FPT0WU
CAKI-1NH[5e3BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NInUTXpKSzVyPUCuN|IyOTFizszNNYGy[HZGW0GQR1XS
UACC-62NXXQdYl1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M4LsOGlEPTB;MD6zNlIzPyEQvF2=MmWzV2FPT0WU
HuCCT1M3\aT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7MUXJR|UxRTBwM{KyPFMh|ryPM3noXHNCVkeHUh?=
CTB-1M4TVNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NGexWnJKSzVyPUCuN|I4PTNizszNNXv1bYpvW0GQR1XS
NTERA-S-cl-D1MoHWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MkS2TWM2OD1yLkOyPFM3KM7:TR?=NGfzUXlUSU6JRWK=
T-24NH;ib4lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NF7lcI1KSzVyPUCuN|MyPTlizszNMVPTRW5ITVJ?
KYSE-70MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NHL5UmhKSzVyPUCuN|MzQDNizszNMlPIV2FPT0WU
SW626NX60SI5LT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MYXJR|UxRTBwM{O1N|Ih|ryPMlzLV2FPT0WU
LB996-RCCMWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MWrJR|UxRTBwM{O2NVkh|ryPNX\ucJlkW0GQR1XS
DMS-273MoC2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M4rmXWlEPTB;MD6zN|kyPiEQvF2=MnrEV2FPT0WU
SW1783MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MUDJR|UxRTBwM{O5PVch|ryPNWjWSVd3W0GQR1XS
KU812NFHJR4pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NGLySHhKSzVyPUCuN|QxOzhizszNNFjBXmlUSU6JRWK=
HSC-2NHPjOnRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NIfiTnVKSzVyPUCuN|QxPTNizszNMnXUV2FPT0WU
A3-KAWMW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MoLGTWM2OD1yLkO0NVYzKM7:TR?=MoHOV2FPT0WU
COLO-684NEnDZXdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M333N2lEPTB;MD6zOFUxOSEQvF2=MYHTRW5ITVJ?
NCI-H2405MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M1W1c2lEPTB;MD6zOFY{OSEQvF2=M13DU3NCVkeHUh?=
NCI-H2228NEfEeIlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M1jSe2lEPTB;MD6zOVM2PyEQvF2=MXXTRW5ITVJ?
NB13MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MUPJR|UxRTBwM{[4Nlkh|ryPNETH[5JUSU6JRWK=
no-11NHv2XnVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M3O4PWlEPTB;MD6zOlk2KM7:TR?=M1SxbnNCVkeHUh?=
DK-MGMoDqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NYC1fVZpUUN3ME2wMlM4OTh6IN88US=>MVTTRW5ITVJ?
NBsusSRNY[zW3FRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MUHJR|UxRTBwM{eyPFUh|ryPM1;Oe3NCVkeHUh?=
KP-N-YSNHnZWXlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M4LYOmlEPTB;MD6zO|Q3OyEQvF2=M{XZ[nNCVkeHUh?=
CFPAC-1Ml\OS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M{C3UWlEPTB;MD6zO|UyQCEQvF2=NEToUGRUSU6JRWK=
KARPAS-45NFXTfYNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=Mn\CTWM2OD1yLkO3PFYzKM7:TR?=MXvTRW5ITVJ?
NCI-H1793Mm\KS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NHrYPIdKSzVyPUCuN|g2OSEQvF2=MmHqV2FPT0WU
HCE-TM1;Wb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7MUXJR|UxRTBwM{i2NFMh|ryPM4LQXnNCVkeHUh?=
NCI-H520M1rrTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7Mn\LTWM2OD1yLkO4O|A{KM7:TR?=MWfTRW5ITVJ?
HCC2157MkDvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NGrWSVRKSzVyPUCuN|g4QDFizszNM2rqTnNCVkeHUh?=
EW-18NV7wSIprT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M3HGb2lEPTB;MD6zPFk1OSEQvF2=MofRV2FPT0WU
RO82-W-1MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NGfLZ4xKSzVyPUCuN|k3QTlizszNNXfzW4lFW0GQR1XS
HuP-T3M{TZPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MnzYTWM2OD1yLkSwNVQ{KM7:TR?=MYfTRW5ITVJ?
PANC-10-05NYPsW2kxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MkDYTWM2OD1yLkSxNVch|ryPMWrTRW5ITVJ?
NCI-H1703MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MVrJR|UxRTBwNEG0OFYh|ryPNX6zOJJZW0GQR1XS
TE-10MofWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MYjJR|UxRTBwNEG0OFch|ryPMU\TRW5ITVJ?
HOSMkjhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NUL2Vlg{UUN3ME2wMlQyPjh{IN88US=>MWjTRW5ITVJ?
LN-405NVnt[HBzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NETRTZdKSzVyPUCuOFE3QDdizszNMVzTRW5ITVJ?
A427NGjqeI9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MWTJR|UxRTBwNEG5PFEh|ryPMXzTRW5ITVJ?
CAL-12TNI\SUIhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NUTwR5Z2UUN3ME2wMlQzPzhizszNMWTTRW5ITVJ?
SW756NH7DZ3hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M{nGUGlEPTB;MD60OFE5OyEQvF2=MUPTRW5ITVJ?
YAPCNFTHNWJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=Ml;lTWM2OD1yLkS1NFgh|ryPNGjUd4FUSU6JRWK=
GOTOMYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MoPqTWM2OD1yLkS1NVYh|ryPM2HWWHNCVkeHUh?=
C3AM{XJZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M1jnW2lEPTB;MD60OVQ{PyEQvF2=MVXTRW5ITVJ?
UM-UC-3NYP4TXFvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MkG0TWM2OD1yLkS1OFch|ryPMV3TRW5ITVJ?
NCI-H1573M1zZNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NYL5TodSUUN3ME2wMlQ2PTZ7IN88US=>NELZOWFUSU6JRWK=
LS-411NNELoSmhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=Mlq4TWM2OD1yLkS2OVI4KM7:TR?=Mm\hV2FPT0WU
COR-L23MlrzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M1O5N2lEPTB;MD60Olc3PCEQvF2=NXnIcnBvW0GQR1XS
HCE-4NYH2XGJsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MU\JR|UxRTBwNEe0OFYh|ryPNVjWVnR7W0GQR1XS
NCI-H2291NFXjXHZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NIHmWopKSzVyPUCuOFc5QTZizszNNHe4OXlUSU6JRWK=
A101DMmraS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MXPJR|UxRTBwNEiwOVMh|ryPNGn1UVNUSU6JRWK=
HT-3MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M{PXUmlEPTB;MD60PFIyPyEQvF2=Mn3UV2FPT0WU
HOP-62M3HyRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NWHzZmRkUUN3ME2wMlQ6QDZ3IN88US=>M{PRZXNCVkeHUh?=
PC-3NVHTWlRTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MmPjTWM2OD1yLkWxOVA4KM7:TR?=NWKySHpUW0GQR1XS
CTV-1NWXMeHNFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M1SzPWlEPTB;MD61NlY3QSEQvF2=NF\FZZJUSU6JRWK=
PANC-08-13NWfzdlVUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=Ml;3TWM2OD1yLkWzNVc4KM7:TR?=NHrwTnlUSU6JRWK=
CAL-120M3vufGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MUfJR|UxRTBwNUOzPVkh|ryPMoL2V2FPT0WU
UMC-11M4j3NGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M3zINmlEPTB;MD61OVI{PCEQvF2=Mn7QV2FPT0WU
MSTO-211HNX[4N|Q4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NGfHOFBKSzVyPUCuOVU4PjJizszNM{jUd3NCVkeHUh?=
NCI-H2126NHTicWFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NIXC[m1KSzVyPUCuOVY5OTVizszNNEXYZYxUSU6JRWK=
SNU-C2BMn2zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NH;kS2RKSzVyPUCuOVc6PzdizszNNGDQZ5VUSU6JRWK=
DBTRG-05MGMU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M1K1fmlEPTB;MD61PFA2OyEQvF2=MlrkV2FPT0WU
MKN1MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NYTwWJJoUUN3ME2wMlU5Pzh|IN88US=>M4HiWHNCVkeHUh?=
ES3MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NHPOSZZKSzVyPUCuOVkyOjRizszNMXfTRW5ITVJ?
OVCAR-3NXK1V|N5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M3XKTWlEPTB;MD61PVM1OSEQvF2=NYDFT|h[W0GQR1XS
ACHNM3LDUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MnLDTWM2OD1yLk[wOVY6KM7:TR?=NEXCPFZUSU6JRWK=
SW872MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NH[2eHdKSzVyPUCuOlA4PjNizszNMYjTRW5ITVJ?
CP66-MELM4rZPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NFfuVWRKSzVyPUCuOlA6PjlizszNMmDXV2FPT0WU
NCI-H661NYTiboVtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MmLiTWM2OD1yLk[xNVA1KM7:TR?=NYHmb3l3W0GQR1XS
UACC-893NEjxR2VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=Mn\MTWM2OD1yLk[zOlgyKM7:TR?=MXvTRW5ITVJ?
JVM-3MnzFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NFzud25KSzVyPUCuOlM5ODRizszNNYPISnM6W0GQR1XS
SF268M3PjXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M4TudGlEPTB;MD62OFM1QSEQvF2=MUnTRW5ITVJ?
OCI-AML2MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NUTBbFlKUUN3ME2wMlY2Ozl5IN88US=>MmHVV2FPT0WU
RPMI-8226M1j0eWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M1zEVGlEPTB;MD62OlMzOyEQvF2=M4HPXHNCVkeHUh?=
MKN28MnHXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NXjKXo4{UUN3ME2wMlY3PjJ2IN88US=>Mlu3V2FPT0WU
MDA-MB-453MkXvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NV3NbYJZUUN3ME2wMlY4OThizszNNVrkWWU{W0GQR1XS
BV-173MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NUP4elg5UUN3ME2wMlY5Pjd7IN88US=>Ml7UV2FPT0WU
NCI-H358NE\ke2tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MUHJR|UxRTBwNki3NlYh|ryPNUPLZ3k5W0GQR1XS
NCI-H1651MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NYC2WHVmUUN3ME2wMlch|ryPMVvTRW5ITVJ?
MDA-MB-415MnXOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NYr3SVhPUUN3ME2wMlcxQDJ7IN88US=>M1LDOXNCVkeHUh?=
8305CMoPJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NYLRRmk3UUN3ME2wMlczPDl6IN88US=>M4LWWnNCVkeHUh?=
EFM-19MoDIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M{fDeWlEPTB;MD63N|Y4OSEQvF2=M3ruS3NCVkeHUh?=
RERF-LC-MSMWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NU[3NG5QUUN3ME2wMlc1PjF|IN88US=>MoHRV2FPT0WU
A388MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MmewTWM2OD1yLke2OFY4KM7:TR?=MknlV2FPT0WU
GI-ME-NNGPIdIpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M37XTGlEPTB;MD63O|I{PSEQvF2=M3LxTnNCVkeHUh?=
IGR-1MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NFPWTlBKSzVyPUCuO|kxPDNizszNNXHmdGF7W0GQR1XS
LNCaP-Clone-FGCM33WVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NW[0SXlpUUN3ME2wMlgxODB2IN88US=>NV\1THpjW0GQR1XS
SK-MEL-3Mmi4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NWDDR4xJUUN3ME2wMlgyPTB6IN88US=>MnzpV2FPT0WU
UACC-257MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NIjEWYxKSzVyPUCuPFIzOzFizszNMn[wV2FPT0WU
OE33M2LCVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NGPSXFZKSzVyPUCuPFUyODFizszNMlLTV2FPT0WU
QIMR-WILNHfN[nZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NWW2RXpqUUN3ME2wMlg2OTRzIN88US=>M4LHZ3NCVkeHUh?=
NCI-H2009NFvKd5pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MoXETWM2OD1yLki1N|EyKM7:TR?=NXrDSYtpW0GQR1XS
NCI-H522NGixRnZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NWXlfG4yUUN3ME2wMlg4Pzh|IN88US=>NH\QTHBUSU6JRWK=
Saos-2MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M1K5VWlEPTB;MD64O|g4OSEQvF2=NHLJTYlUSU6JRWK=
NB17NIL2[FBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MV3JR|UxRTBwOEiwNlUh|ryPMmfXV2FPT0WU
D-392MGMn7XS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NVWxVWxTUUN3ME2wMlg6OzV4IN88US=>M1;NSnNCVkeHUh?=
SHP-77M1HwXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NYK1dFl2UUN3ME2wMlkxPDh3IN88US=>NWG3WXVbW0GQR1XS
SK-MEL-30MmfmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NVr3SVNRUUN3ME2wMlkyOTh3IN88US=>NVHNSZRRW0GQR1XS
GCIYNIDPTWJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NUTPWXlzUUN3ME2wMlkyQDR|IN88US=>M{TjOXNCVkeHUh?=
HCC70NYO1TnVMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NVzwVXRJUUN3ME2wMlkzODV7IN88US=>MU\TRW5ITVJ?
LU-65Ml7RS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MUXJR|UxRTBwOUK1PVEh|ryPMUjTRW5ITVJ?
NCI-H1563M4exU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7NFWwV|BKSzVyPUCuPVQ5PjVizszNM{X4UXNCVkeHUh?=
KURAMOCHIMmjwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NHXUcXRKSzVyPUCuPVUyQTJizszNMn6zV2FPT0WU
PA-1MnvyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MljJTWM2OD1yLkm1OFI1KM7:TR?=MUfTRW5ITVJ?
NOS-1M2rIZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MVPJR|UxRTBwOUe0PFkh|ryPNILDNpVUSU6JRWK=
NCI-H69MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MUDJR|UxRTBwOUe2N|Qh|ryPNYXXdIFIW0GQR1XS
KYSE-450NWX5SpZjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NGPSfGFKSzVyPUCuPVg3OjZizszNMUHTRW5ITVJ?
8505CNH[wNZhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NHXZ[ZpKSzVyPUCuPVk6QDJizszNNUXsRpU5W0GQR1XS
TGBC24TKBMkTPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M33vdmlEPTB;MT6wNFA5PCEQvF2=NUXjcVBNW0GQR1XS
PFSK-1M{[2Z2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7NV2yfoxUUUN3ME2xMlAyPDJ6IN88US=>NVzONoY2W0GQR1XS
EKVXNEnZUGJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NFvJTYtKSzVyPUGuNFMyOjFizszNM2TtOHNCVkeHUh?=
RCM-1NIDudVFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MYDJR|UxRTFwMEW1NFch|ryPMoHuV2FPT0WU
SW900MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MoXNTWM2OD1zLkC3PFMh|ryPMnjlV2FPT0WU
D-542MGNXrxPJhvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NV3Kb4xmUUN3ME2xMlA4QDV3IN88US=>MXzTRW5ITVJ?
SK-PN-DWMY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NGfNNJNKSzVyPUGuNVAxPTZizszNNX[0[YRrW0GQR1XS
NCI-H727MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NXf2Z5NLUUN3ME2xMlExOTV2IN88US=>MnrpV2FPT0WU
SW837MkDUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NHnXS|lKSzVyPUGuNVA6PTRizszNM{XVdHNCVkeHUh?=
BT-20NEPtbpBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=Mn7xTWM2OD1zLkGxNlA1KM7:TR?=Ml73V2FPT0WU
RH-18M17ZV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7M3:0Z2lEPTB;MT6xN|ExOyEQvF2=NFnrNVdUSU6JRWK=
TE-12MlXIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MkXxTWM2OD1zLkGzN|M{KM7:TR?=NGLO[FhUSU6JRWK=
NB10MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MYLJR|UxRTFwMUOzOFQh|ryPNVfnSZVHW0GQR1XS
AU565NHHnS5NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M1HpN2lEPTB;MT6xOVk4OyEQvF2=NUCyZY1GW0GQR1XS
OAW-42MnzqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MUTJR|UxRTFwMUizNFYh|ryPNGPIZ|dUSU6JRWK=
DJM-1MkPlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NHTjemZKSzVyPUGuNVk5QDFizszNMWjTRW5ITVJ?
HHNYDORnZST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MV7JR|UxRTFwMkO4N|Eh|ryPM4jGUXNCVkeHUh?=
LAMA-84MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NFHyVnRKSzVyPUGuNlc{QTRizszNMmrlV2FPT0WU
KNS-42MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M33w[GlEPTB;MT6zNFI6PiEQvF2=MnTFV2FPT0WU
NCI-H2052NIHkZ2pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NGLwVphKSzVyPUGuN|A2ODdizszNM{KwWHNCVkeHUh?=
MLMAMnHES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MWnJR|UxRTFwM{K0NFch|ryPMmPpV2FPT0WU
NB12Mnq4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M1G5SWlEPTB;MT6zOVY{PiEQvF2=MULTRW5ITVJ?
NCI-H1838NIjxcnRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NEXrcVlKSzVyPUGuN|Y{ODZizszNNXv3bHFIW0GQR1XS
NCI-H526M1fGSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NWHX[nN5UUN3ME2xMlM4QDV|IN88US=>M4nibXNCVkeHUh?=
LS-123MlziS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MV\JR|UxRTFwM{mwPVQh|ryPMXLTRW5ITVJ?
HDLM-2M13PWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NFP3SpdKSzVyPUGuN|kzPzFizszNMYrTRW5ITVJ?
MC-IXCNGLDO4FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M3LEOGlEPTB;MT60NlM4OSEQvF2=MXLTRW5ITVJ?
HCT-15M2O5W2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7NEDxdVJKSzVyPUGuOFMxPjhizszNM2jRPXNCVkeHUh?=
NCI-H596NWSwPJgzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NWj6fpVSUUN3ME2xMlQ2ODZzIN88US=>MV\TRW5ITVJ?
ZR-75-30M3mwXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MVnJR|UxRTFwNEewPFIh|ryPMn;tV2FPT0WU
A704M2jONWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NIPJNnNKSzVyPUGuOlY2PjNizszNM3G4fnNCVkeHUh?=
OVCAR-4MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MnPOTWM2OD1zLk[5OlA4KM7:TR?=NGS4OZBUSU6JRWK=
SW1417MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MkTITWM2OD1zLkeyPFQ6KM7:TR?=NF7JUWdUSU6JRWK=
CAS-1NISxS|VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MYXJR|UxRTFwN{O5N|Yh|ryPMWjTRW5ITVJ?
IST-SL1M3i2b2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7NVHPW2FLUUN3ME2xMlc6PzV7IN88US=>NI\nVmZUSU6JRWK=
A253MkP3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MojjTWM2OD1zLkiyNlM6KM7:TR?=NHLVZlNUSU6JRWK=
EW-16NHzYRoNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M4r6TGlEPTB;MT64Nlg4PSEQvF2=MlzSV2FPT0WU
SK-NEP-1NH7KXHJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=Mkf0TWM2OD1zLki2PVg5KM7:TR?=NUPZVoh{W0GQR1XS
NCI-H226NUDYU3JVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NEKzVVlKSzVyPUGuPFk{PTlizszNM3X2fnNCVkeHUh?=
HOP-92NWXQe41FT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MU\JR|UxRTFwOU[wPVkh|ryPM1\tR3NCVkeHUh?=
NCI-H441MkD6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NV[2VWd[UUN3ME2yMlAzOzN5IN88US=>NHGzT4FUSU6JRWK=
LU-139M2fneWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NXjIOFF3UUN3ME2yMlA{OTF2IN88US=>NX;nbXdQW0GQR1XS
SJRH30NYnTTGRjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=Mo\DTWM2OD1{LkC0NlU{KM7:TR?=NXiwTXNqW0GQR1XS
MG-63M1jt[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7MYTJR|UxRTJwMUSxNVEh|ryPMYnTRW5ITVJ?
NH-12Mk\WS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M2HBZmlEPTB;Mj6xOVAxPiEQvF2=Mk\kV2FPT0WU
NB7MkOyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NUHGT4xqUUN3ME2yMlE6Pjd|IN88US=>NEe0UYRUSU6JRWK=
LB771-HNCMXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MlrPTWM2OD1{LkKwOVk2KM7:TR?=M4PPZ3NCVkeHUh?=
HCC1569M{XTNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NUWxdHp5UUN3ME2yMlI1PTh|IN88US=>MmTVV2FPT0WU
D-283MEDMXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M4PZTmlEPTB;Mj6yOFc5OiEQvF2=MUDTRW5ITVJ?
J-RT3-T3-5M3TrbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M3OydGlEPTB;Mj6yOVM2OSEQvF2=M4XGW3NCVkeHUh?=
ATN-1MmXTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NYLZVm1pUUN3ME2yMlM{ODh{IN88US=>NWnRZot[W0GQR1XS
HCC1954NEXn[|hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NGP3bVVKSzVyPUKuN|Q1ODhizszNNGT2N5hUSU6JRWK=
SCC-15NYi4VGZzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MVjJR|UxRTJwM{mzNVIh|ryPNUDqcFZZW0GQR1XS
COLO-668MoPTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NHzpTmpKSzVyPUKuOFMzKM7:TR?=MWTTRW5ITVJ?
LB373-MEL-DM2DiPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7Mmr3TWM2OD1{LkW0Olc4KM7:TR?=NF7BV4FUSU6JRWK=
no-10MmrPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M4C2[2lEPTB;Mj61OFk1PyEQvF2=NVnDSWdMW0GQR1XS
HT-1197Mmq5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MofqTWM2OD1{Lk[zNVg5KM7:TR?=MkH4V2FPT0WU
DU-145NGPUZlRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MknuTWM2OD1{Lke5NVYzKM7:TR?=M3;MbHNCVkeHUh?=
SK-N-ASMnzhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M4X2VGlEPTB;Mj64OFY6OiEQvF2=M3jGV3NCVkeHUh?=
MOLT-4NUPvXWdrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MUPJR|UxRTJwOEWzNlIh|ryPMULTRW5ITVJ?
EW-22M1LvVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M3jxbGlEPTB;Mj65Nlg1OSEQvF2=NFeybIdUSU6JRWK=
DBMlfCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MmLhTWM2OD1{Lkm3O|U6KM7:TR?=NWS0PW9yW0GQR1XS
HL-60NXSyS4ZMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M4G3PGlEPTB;Mz6wOFM4PiEQvF2=MnuzV2FPT0WU
SK-N-DZM3TDdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NFXTZoxKSzVyPUOuNFUxPzVizszNMVfTRW5ITVJ?
NYMXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MXzJR|UxRTNwMEi1OFIh|ryPMXnTRW5ITVJ?
T47DNGDHN|VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=Mn;jTWM2OD1|LkGwOVU5KM7:TR?=M1vETHNCVkeHUh?=
NCI-H2029MmrFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M3fUfWlEPTB;Mz6yNlQ4PyEQvF2=MnfWV2FPT0WU
KARPAS-299M{WzPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M{XTcGlEPTB;Mz6yOlAzPyEQvF2=MUjTRW5ITVJ?
KM-H2NGfBRmhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NH7uSohKSzVyPUOuN|A3QCEQvF2=NGrib45USU6JRWK=
CHP-134NULtbWd4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MUjJR|UxRTNwNEezPUDPxE1?MoP1V2FPT0WU
22RV1NVXWclFQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M4D0ZmlEPTB;Mz60PVE3QCEQvF2=NVzSSFhpW0GQR1XS
NB5NYjC[GZ{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NXewdYZ3UUN3ME2zMlUxPjh7IN88US=>NFXTSotUSU6JRWK=
CW-2NW\FNmF4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M{XSSGlEPTB;Mz61OVMyPCEQvF2=MkTCV2FPT0WU
EFO-21M1W3bGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NESzc3dKSzVyPUOuOVY6PCEQvF2=NYnTRWhDW0GQR1XS
HuH-7NF;6OI9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M4fJSWlEPTB;Mz61PFQyPCEQvF2=NW[4OpRkW0GQR1XS
ALL-PONGTXcZNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M3zHVWlEPTB;Mz62NlM{PSEQvF2=MorLV2FPT0WU
EM-2M4O2OWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NXzrO21CUUN3ME2zMlY6ODFzIN88US=>NFHEeHdUSU6JRWK=
KLEM3rlemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MV\JR|UxRTNwN{OwNlkh|ryPMVfTRW5ITVJ?
NEC8MnzGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MlHHTWM2OD1|LkmxPFA5KM7:TR?=NGr3dHJUSU6JRWK=
KP-N-YNMkWxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MXzJR|UxRTNwOUO0O|Yh|ryPMo\hV2FPT0WU
SK-MEL-1M{fOO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7MYnJR|UxRTRwMEO1NVgh|ryPMkDsV2FPT0WU
CAL-54NWnVSodqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NXrVZo9{UUN3ME20MlA2QTFizszNM4fHSHNCVkeHUh?=
MS-1MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NGWweGJKSzVyPUSuNVYyPTVizszNMVrTRW5ITVJ?
NCI-H209MkHTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MXLJR|UxRTRwMkm5PVkh|ryPNF7jR2dUSU6JRWK=
NOMO-1NHHOZpNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MnnTTWM2OD12LkOyNVMyKM7:TR?=MYPTRW5ITVJ?
RPMI-2650MlTSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M{jtcmlEPTB;ND6zOlMzPyEQvF2=NXuzcHBjW0GQR1XS
NCI-H810NEOzOZFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NVjTSIdRUUN3ME20MlM6PzN4IN88US=>NXHwUHd6W0GQR1XS
Ca9-22M1PRb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7M{fTXmlEPTB;ND60OVY6OSEQvF2=MlvXV2FPT0WU
ES4MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MoXwTWM2OD12LkS3NFk2KM7:TR?=MWfTRW5ITVJ?
ES6NYLvUJQ3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NVTtfYp{UUN3ME20MlQ6PjV5IN88US=>NYL1UJlmW0GQR1XS
DMS-114Ml23S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NGPPd3lKSzVyPUSuOVQ3QTFizszNNX64[ZF[W0GQR1XS
ONS-76M1zVZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MWLJR|UxRTRwNUe5OUDPxE1?M33rUXNCVkeHUh?=
K-562M3n0e2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7MX7JR|UxRTRwN{O4NVQh|ryPMmT5V2FPT0WU
MHH-NB-11MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MVXJR|UxRTRwN{W0OlEh|ryPMXPTRW5ITVJ?
Calu-3MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M{H0emlEPTB;ND63PFU1QCEQvF2=NYroV2Q1W0GQR1XS
HT55MmTrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MlTtTWM2OD12Lki0OVQ2KM7:TR?=NHS1RnZUSU6JRWK=
SK-N-FIMVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NVTtZVdlUUN3ME20Mlg2ODB7IN88US=>MUXTRW5ITVJ?
ES1MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MWrJR|UxRTRwOE[wOVch|ryPNIW4ZlFUSU6JRWK=
SF126MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NVjvdWp7UUN3ME20Mlk{OTh2IN88US=>M3jqNXNCVkeHUh?=
ES5NUjoe2N6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M2T6XmlEPTB;NT6xNlQzPyEQvF2=MWHTRW5ITVJ?
LoVoMXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NFP4UHhKSzVyPUWuNVU5PzFizszNM4DWRnNCVkeHUh?=
SNU-387MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NV7yWYtUUUN3ME21MlMzOzN7IN88US=>NH:xVFBUSU6JRWK=
C8166NVzKNFh2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M3H3b2lEPTB;NT6zOlM{QSEQvF2=NXTJW45XW0GQR1XS
LS-1034NHzRS2lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NH\IcFJKSzVyPUWuOFI{ODdizszNNVnyZVFkW0GQR1XS
GR-STMmP5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NVTCXI1lUUN3ME21MlUzOjBzIN88US=>MYHTRW5ITVJ?
NCI-H1092NWnEb2o6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NInabINKSzVyPUWuO|I5PDNizszNNXzmN5AxW0GQR1XS
647-VMoTDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MXHJR|UxRTVwN{S3NFYh|ryPM{f0S3NCVkeHUh?=
EW-13NUjEWmM3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MoHvTWM2OD13Lke2OlI4KM7:TR?=M{\HWnNCVkeHUh?=
KGNNULOTWZqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MoPXTWM2OD14LkC5PVIyKM7:TR?=NEnWcG5USU6JRWK=
D-423MGMlLaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M4i2UGlEPTB;Nj60NFI5PCEQvF2=NVzxZnBIW0GQR1XS
ECC10NYLr[4Z5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MlPPTWM2OD15LkGwNVAyKM7:TR?=NEfTZVdUSU6JRWK=
TE-5NIrPOmhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NVnDUGRDUUN3ME23MlQyOjl6IN88US=>MXLTRW5ITVJ?
P12-ICHIKAWAMWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MVXJR|UxRTdwNEW1NlMh|ryPNYDIXnQ{W0GQR1XS
NCI-H82Mmm0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M1;sfmlEPTB;Nz60OVcxOSEQvF2=MnGyV2FPT0WU
NCI-H1993Mmr3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NYPkc4NmUUN3ME23Mlg{ODZ|IN88US=>MVjTRW5ITVJ?
RH-1NXL6RYdIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NW\BPHdDUUN3ME23Mlg2OjR2IN88US=>M3K5cXNCVkeHUh?=
SW948NUHLcJlGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NUe3Omt3UUN3ME23Mlk3ODR7IN88US=>MVnTRW5ITVJ?
CAL-33NV7NbJZMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MUDJR|UxRTdwOUm5N|gh|ryPMX\TRW5ITVJ?
U-266NI\QbXdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NIHrRo1KSzVyPUiuNVU4PzdizszNMWXTRW5ITVJ?
CAL-72MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MULJR|UxRThwMkCzNkDPxE1?NIjjXHdUSU6JRWK=
SNU-423MoDTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M17NZWlEPTB;OT6zOlY3PiEQvF2=NWPQWoh7W0GQR1XS
KG-1M4\Rfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M4rPRWlEPTB;OT61PFQ2PiEQvF2=MkTmV2FPT0WU
HCC1395NXfLXItIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MV7JR|UxRTlwOUKzOVIh|ryPNXPZ[nJnW0GQR1XS
BE-13MknaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NIDiO4VKSzVyPUGwMlg5QTJizszNMkS1V2FPT0WU
MKN7MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NVPGc4dSUUN3ME2xNE46PzZ3IN88US=>Ml3oV2FPT0WU
697MlWxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M1Xsc2lEPTB;MUGuNVQ4OiEQvF2=NHv2e2lUSU6JRWK=
LU-135Mkn1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NHvYPXJKSzVyPUGxMlI{ODdizszNMk[zV2FPT0WU
ES7M3;IZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NVLFPIhlUUN3ME2xNU4{OzF|IN88US=>M2rXWnNCVkeHUh?=
SK-HEP-1MnfDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NFX5[JdKSzVyPUGxMlc3PDZizszNMojJV2FPT0WU
BENMYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NFrEfFBKSzVyPUGxMlg2OSEQvF2=NW\2Um5iW0GQR1XS
NCI-H1770MoDES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MonKTWM2OD1zMj6xNlYh|ryPMV7TRW5ITVJ?
SW13NWrQTllPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NE\pNm5KSzVyPUGyMlE2PDFizszNMnfCV2FPT0WU
MZ1-PCMn\xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NHjabIRKSzVyPUGyMlU1PTJizszNNHnJRY1USU6JRWK=
Mo-TMWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M{iydmlEPTB;MUKuO|QzOSEQvF2=Mo[0V2FPT0WU
HLEMUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NXnudpdVUUN3ME2xNk45OjF3IN88US=>NULPcI1iW0GQR1XS
RCC10RGBNH7ETXVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NX;XeWllUUN3ME2xN{43PzFizszNNW\0cWtDW0GQR1XS
COLO-320-HSRMXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M{HNXmlEPTB;MUOuO|M5OSEQvF2=MUXTRW5ITVJ?
BHT-101MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NUjoe4RuUUN3ME2xN{45OzR3IN88US=>MlLiV2FPT0WU
OCUB-MNGfTfnFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NV;STIg1UUN3ME2xOE4yPjB{IN88US=>MXfTRW5ITVJ?
MEG-01NUTIfGEzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NX3CXZlIUUN3ME2xOE4{PzB6IN88US=>MVXTRW5ITVJ?
RS4-11MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MonETWM2OD1zND63OFIh|ryPNFHBZpVUSU6JRWK=
MN-60NGjwd5pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NILCdZpKSzVyPUG0Mlc5QTRizszNNXrEPI9SW0GQR1XS
NCI-H1304MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MVvJR|UxRTF3LkC0NlUh|ryPMn73V2FPT0WU
Ramos-2G6-4C10NYDCTJNKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MVfJR|UxRTF3LkC1PFEh|ryPNWL5UIp5W0GQR1XS
NCI-H2342NYHYU3VQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M33tSGlEPTB;MUWuNlA1PCEQvF2=NHiwZWdUSU6JRWK=
LAN-6M3fES2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7NEfofZZKSzVyPUG1MlQ1OTRizszNMUPTRW5ITVJ?
JVM-2M4jIWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MnSyTWM2OD1zNT61O|Q5KM7:TR?=M4fRPXNCVkeHUh?=
P30-OHKM2XpSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MXXJR|UxRTF4LkC2NVQh|ryPNGnl[YRUSU6JRWK=
C-33-ANVjvR5Y{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NVHIXohQUUN3ME2xOk43OjF2IN88US=>NELORm9USU6JRWK=
RPMI-8866MlzWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NWnRWYl6UUN3ME2xOk45PDl4IN88US=>NWfwWWpNW0GQR1XS
NCI-H630NE\vXYxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NWPjS4tmUUN3ME2xOk45PTN5IN88US=>MkHSV2FPT0WU
KYSE-140NVLwOFRbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MUHJR|UxRTF5LkKwNlgh|ryPNVn2dGw6W0GQR1XS
T84MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MVfJR|UxRTF6Lki2PVUh|ryPMXfTRW5ITVJ?
KU-19-19MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MUnJR|UxRTF6Lkm2NFgh|ryPMn:5V2FPT0WU
BALL-1MmjNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NWqzTWkzUUN3ME2xPU4{Ozl7IN88US=>M2nyUnNCVkeHUh?=
Calu-6M4C4eWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MWfJR|UxRTF7LkS5NkDPxE1?M2fHS3NCVkeHUh?=
EGI-1NGe4Z2lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NXXtN21QUUN3ME2xPU42QThizszNMkSyV2FPT0WU
MFH-inoNHHnSINIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NHm2VoVKSzVyPUG5Mlc1PTRizszNMnLRV2FPT0WU
GB-1NYjoUphlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NWPR[IJXUUN3ME2yNE4{PTN3IN88US=>NUWxUIV1W0GQR1XS
NCI-H1693M13UdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NWG3WIFRUUN3ME2yNE43PTB3IN88US=>NH\FNFRUSU6JRWK=
SW1116MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MV\JR|UxRTJyLkmzOlIh|ryPMl3lV2FPT0WU
H-EMC-SSMVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NWjLNZNOUUN3ME2yNk4xPDVizszNNHrrU4tUSU6JRWK=
D-502MGMojBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M4j5N2lEPTB;MkKuPFI3OSEQvF2=MX3TRW5ITVJ?
IA-LMMnLLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NVfmN41vUUN3ME2yN{4zPDl|IN88US=>NWe0N5hVW0GQR1XS
SW1463NXvNbWZwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M2jjWWlEPTB;MkOuO|kh|ryPNVO5eohCW0GQR1XS
JARMUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MX3JR|UxRTJ2LkOyPVMh|ryPNFf4UllUSU6JRWK=
HTMW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M3q2UmlEPTB;MkSuOFc2OyEQvF2=MoPEV2FPT0WU
LCLC-103HMmHWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NHPkSZNKSzVyPUK0Mlg1PDlizszNMV;TRW5ITVJ?
SNU-449NXzmS202T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MUnJR|UxRTJ2Lki3OFEh|ryPMWfTRW5ITVJ?
KE-37NH[zcphIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=Mn7DTWM2OD1{NT6wPVI5KM7:TR?=MoLZV2FPT0WU
NCI-H1623M1[5Zmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M3LC[2lEPTB;MkeuNVMxOyEQvF2=M33kVnNCVkeHUh?=
MOLT-13NF;IVplIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NXy2[Xh[UUN3ME2yO{4{PTF4IN88US=>M3j1ZnNCVkeHUh?=
COLO-741NWTXcmhrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NEnVT2xKSzVyPUOxMlM{OzNizszNNV\WZ3B7W0GQR1XS
NB6MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M3z4U2lEPTB;M{KuNlg4PiEQvF2=MWfTRW5ITVJ?
MOLT-16NYTMc4VWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MUHJR|UxRTN|LkCwOVUh|ryPMWnTRW5ITVJ?
IST-MES1NEexXYFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M17NU2lEPTB;M{SuNFU1OSEQvF2=MXfTRW5ITVJ?
A4-FukMX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NGe3PY1KSzVyPUO1MlA3PiEQvF2=NIGyeZhUSU6JRWK=
CAL-85-1NEnUZlJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MmfhTWM2OD1|NT6yPFE4KM7:TR?=NU[2emkxW0GQR1XS
CCRF-CEMNHrQcmVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M2qxbWlEPTB;M{euNVU{PiEQvF2=NVz0[ldUW0GQR1XS
HAL-01Ml[5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MYDJR|UxRTN6LkS4PFkh|ryPMoLGV2FPT0WU
HELMWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MYLJR|UxRTR|LkO0NFkh|ryPNHfYPYZUSU6JRWK=
EW-1MmPWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MnTOTWM2OD12Mz60O|Y5KM7:TR?=NX3XZWRqW0GQR1XS
MDA-MB-231Ml71S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MV7JR|UxRTR3LkGxPVkh|ryPM1r4RnNCVkeHUh?=
ABC-1MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MVfJR|UxRTR4Lki1N|gh|ryPMofmV2FPT0WU
NCI-H446NX3Qb3p3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NWj1elRqUUN3ME20PE42ODV6IN88US=>MlfvV2FPT0WU
MHH-PREB-1MlHaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NEf2NWNKSzVyPUS5MlYxODdizszNM3O1enNCVkeHUh?=
DOHH-2M4nPV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7NIO1Z3hKSzVyPUS5MlY3PTZizszNMnqzV2FPT0WU
GCTNYrhXVd4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NXTZfZhTUUN3ME20PU43QTd4IN88US=>MUjTRW5ITVJ?

... Click to View More Cell Line Experimental Data

In vivo 17-AAG displays significantly higher binding affinity for Hsp90 from 3T3-src, B16 or CT26 xenografts in nude mice with IC50 values of 8-35 nM as compared with that from the normal tissues with IC50 values of 200-600 nM. [1] Administration of 17-AAG (~50 mg/kg) causes significant decline in AR, HER2, HER3, and Akt expression in a dose-dependent manner with >50% decline at dose of 50 mg/kg, resulting in the dose-dependent inhibition of androgen-dependent (CWR22) and -independent (CWR22R and CWRSA6) prostate cancer xenografts growth by 67%, 80% and 68% at dose of 50 mg/kg, respectively. [2]
Features Displays very low toxicity toward normal cells.

Protocol(Only for Reference)

Kinase Assay: [1]

Hsp90 binding assays Purified native Hsp90 protein or cell lysates from HER-2-overexpressing cancer cells (BT474, N87, SKOV3 and SKBR3) or BT474 breast carcinoma cells in lysis buffer (20 mM HEPES, pH 7.3, 1 mM EDTA, 5 mM MgCl2, 100 mM KCl) are incubated with various concentrations of 17-AAG for 30 minutes at 4 °C, and then incubated with biotin-GM linked to BioMag streptavidin magnetic beads for 1 hour at 4 °C. Tubes are placed on a magnetic rack, and the unbound supernatant removed. The magnetic beads are washed three times in lysis buffer and heated for 5 minutes at 95 °C in SDS–PAGE sample buffer. Samples are analysed on SDS protein gels, and western blots done using indicated antibodies. Bands in the western blots are quantified using the Bio-rad Fluor-S MultiImager, and the percentage inhibition of binding of Hsp90 to the biotin-GM is calculated. The IC50 reported is the concentration of 17-AAG needed to cause half-maximal inhibition of binding.

Cell Assay: [1]

Cell lines BT474, SKBR3, N87, SKOV3, MCF7, MDA468, Hs578T, Hs578Bst, A549, HT29, U87, SKMG3, HT1080, RPTEC, NDF, HMVEC, HMEC, HUVEC, and PBMC cells
Concentrations Dissolved in DMSO, final concentrations ~10 μM
Incubation Time 5 days
Method Cells are seeded in 96-well plates at 2,000 cells per well in a final culture volume of 100 μL for 24 hours before the addition of increasing concentrations of 17-AAG that is incubated for 5 days. Viable cell number is determined using the Celltiter 96 AQueous Nonradioactive Cell Proliferation Assay. The value of the background absorbance at 490 nm (A490) of wells not containing cells is subtracted. Percentage of viable cells = (A490 of 17-AAG treated sample/A490 untreated cells) × 100. The IC50 is defined as the concentration that gave rise to 50% viable cell number.

Animal Study: [2]

Animal Models Male nu/nu athymic mice inoculated s.c. with androgen-dependent CWR22 xenograft, and female nu/nu athymic mice inoculated s.c. with androgen-independent xenografts CWR22R and CWRSA6
Formulation Dissolved in DMSO, and diluted in egg phospholipids (EPL) vehicle
Dosages ~50 mg/kg
Administration Injection i.p.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

SpeciesMouseRatRabbitGuinea pigHamsterDog
Weight (kg)0.020.151.80.40.0810
Body Surface Area (m2)0.0070.0250.150.050.020.5
Km factor36128520
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Rat dose (mg/kg) = mouse dose (22.4 mg/kg) ×  mouse Km(3)  = 11.2 mg/kg
rat Km(6)
1

References

[1] Kamal A, et al. Nature, 2003, 425(6956), 407-410.

[2] Solit DB, et al. Clin Cancer Res, 2002, 8(5), 986-993.

view more

Clinical Trial Information( data from http://clinicaltrials.gov, updated on 2016-07-30)

NCT Number Recruitment Conditions Sponsor
/Collaborators
Start Date Phases
NCT00577889 Completed Adenocarcinoma of the Pancreas|Recurrent Pancreatic Cancer|Stage IV Pancreatic Cancer National Cancer Institute (NCI) March 2008 Phase 2
NCT00546780 Completed Multiple Myeloma Bristol-Myers Squibb February 2008 Phase 3
NCT00093496 Completed Primary Peritoneal Cavity Cancer|Recurrent Ovarian Epithelial Cancer|Stage III Ovarian Epithelial Cancer|Stage IV Ovarian Epithelial Cancer National Cancer Institute (NCI) October 2007 Phase 2
NCT00514371 Completed Multiple Myeloma Bristol-Myers Squibb August 2007 Phase 2|Phase 3
NCT00779428 Completed Advanced Malignancies Bristol-Myers Squibb July 2006 Phase 2

view more

Chemical Information

Download 17-AAG (Tanespimycin) SDF
Molecular Weight (MW) 585.69
Formula

C31H43N3O8

CAS No. 75747-14-7
Storage 3 years -20℃powder
6 months-80℃in solvent
Synonyms CP127374,NSC-330507, KOS 953
Solubility (25°C) * In vitro DMSO 100 mg/mL (170.73 mM)
Ethanol 5 mg/mL (8.53 mM)
Water <1 mg/mL (<1 mM)
In vivo
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Chemical Name 17-demethoxy-17-(2-propenylamino)- [(3R,5R,6S,7R,8E,10R,11R,12Z,14E)-6-Hydroxy-5,11,21-trimethoxy-3,7,9,15-tetramethyl-16,20,22-trioxo-17-azabicyclo[16.3.1]docosa-1(21),8,12,14,18-pentaen-10-yl] carbamate

Frequently Asked Questions

  • Question 1
    What kind of subtypes does this compound inhibit? HSP90α or HSP90β ?

    Answer: 17-AAG can inhibit both HSP90α and HSP90β, but it is unclear how much are they affected respectively. You should note that Hsp90 derived from tumor cells has a 100-fold higher binding affinity for 17-AAG than that from normal cells according to this paper. http://www.nature.com.ezp-prod1.hul.harvard.edu/nature/journal/v425/n6956/full/nature01913.html

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

* Indicates a Required Field

Related HSP (e.g. HSP90) Products

  • PU-H71

    PU-H71 is a potent and selective inhibitor of HSP90 with IC50 of 51 nM. Phase 1.

  • KNK437

    KNK437 is a pan-HSP inhibitor, which inhibits the synthesis of inducible HSPs, including HSP105, HSP72, and HSP40.

  • VER155008

    VER-155008 is a potent Hsp70 family inhibitor with IC50 of 0.5 μM, 2.6 μM, and 2.6 μM in cell-free assays for HSP70, HSC70, and GRP78, respectively, >100-fold selectivity over HSP90.

  • Luminespib (AUY-922, NVP-AUY922)

    Luminespib (AUY-922, NVP-AUY922) is a highly potent HSP90 inhibitor for HSP90α/β with IC50 of 13 nM /21 nM in cell-free assays, weaker potency against the HSP90 family members GRP94 and TRAP-1, exhibits the tightest binding of any small-molecule HSP90 ligand. Phase 2.

  • Ganetespib (STA-9090)

    Ganetespib (STA-9090) is an HSP90 inhibitor with IC50 of 4 nM in OSA 8 cells, induces apoptosis of OSA cells while normal osteoblasts are not affected; active metabolite of STA-1474. Phase 3.

  • 17-DMAG (Alvespimycin) HCl

    17-DMAG (Alvespimycin) HCl is a potent HSP90 inhibitor with IC50 of 62 nM in a cell-free assay. Phase 2.

    Features:A synthetic derivative Geldanamycin, with lower hepatotoxicity than parent antibiotic & higher potency and bioavailability than the similar derivative 17-AAG.

  • Geldanamycin

    Geldanamycin is a natural existing HSP90 inhibitor with Kd of 1.2 μM, specifically disrupts glucocorticoid receptor (GR)/HSP association.

  • HSP990 (NVP-HSP990)

    NVP-HSP990 (HSP990) is a novel, potent and selective HSP90 inhibitor for HSP90α/β with IC50 of 0.6 nM/0.8 nM.

    Features:NVP-HSP990 is an orally available HSP90 inhibitor and is structurally distinct from other clinical HSP90 inhibitors.

  • Elesclomol (STA-4783)

    Elesclomol (STA-4783) is a novel potent oxidative stress inducer that elicits pro-apoptosis events among tumor cells. Phase 3.

  • Onalespib (AT13387)

    Onalespib (AT13387) is a selective potent Hsp90 inhibitor with IC50 of 18 nM in A375 cells, displays a long duration of anti-tumor activity. Phase 2.

Recently Viewed Items

Tags: buy 17-AAG (Tanespimycin) | 17-AAG (Tanespimycin) supplier | purchase 17-AAG (Tanespimycin) | 17-AAG (Tanespimycin) cost | 17-AAG (Tanespimycin) manufacturer | order 17-AAG (Tanespimycin) | 17-AAG (Tanespimycin) distributor
×
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
Contact Us