Tanespimycin (17-AAG)

Catalog No.S1141 Synonyms: CP127374,NSC-330507, KOS 953

Tanespimycin (17-AAG) Chemical Structure

Molecular Weight(MW): 585.69

Tanespimycin (17-AAG) is a potent HSP90 inhibitor with IC50 of 5 nM in a cell-free assay, having a 100-fold higher binding affinity for HSP90 derived from tumour cells than HSP90 from normal cells. Phase 2.

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9 Customer Reviews

  • (A) Cell lines were seeded in 96-well plates and treated with 10 nM of 17-AAG for 72 h. Cell survival was analyzed using CellTiter-Glo. Both parental H3122 cells (red bar) and H3122 CR cells (blue bar) show sensitivity to 17-AAG. (B) Suppression of ALK signaling by 17-AAG in resistant H3122 CR cells. H3122 parental and resistant cells were exposed to increasing concentrations of 17-AAG for 6 h.

    PNAS, 2011, 108: 7535-40. Tanespimycin (17-AAG) purchased from Selleck.

    (A) Treatment of DIPG cells with an HSP90 inhibitor, 17-AAG, resulted in decreased invasion toward SVZ hNPC CM at high doses. (B) Cell viability of DIPG cells treated with increasing doses of 17-AAG, by the CellTiter-Glo assay.

    Cell, 2017, 170(5):845-859.e19. Tanespimycin (17-AAG) purchased from Selleck.

  • Four types of the colon cancer cells with indicated K-Ras phenotype were incubated with indicated concentration of 17-AAG for 24 h, which were then analyzed for protein expression by WB.

    Oncotarget 2014 5, 4269-82. Tanespimycin (17-AAG) purchased from Selleck.

    Western blot analysis of immunoprecipitated Hsp90/BIP complexes in MOLT-4 (T-ALL) and RS4;11 (B-ALL) treated for 22 h with CX-4945 (5 μM) and bortezomib (2.5 nM) either alone or in combination. 500 μg of protein lysates were immunoprecipitated with anti-Hsp90 antibody. Relative Induction values (Rel.Ind.) were obtained by normalizing to Hsp90 bands density. 17-AAG: tanespimycin.

    Oncotarget, 2015, 51: S659-S660. Tanespimycin (17-AAG) purchased from Selleck.

  • Co-IP analyses of direct interaction between HSP90 and HIF-1α in 17-AAG (5 μM)-treated HSCs using antibodies against HSP90, HIF-1α or IgG (n = 2).

    Br J Pharmacol, 2017, 174(5):409-423. Tanespimycin (17-AAG) purchased from Selleck.

    UPR modulators destabilize mSmoM2. NIH 3T3 cells expressing mSmoM2 protein were treated with HSP90 inhibitors 17-AAG (50 uM and 100 uM) and SNX-2112 (25 uM and 50 uM) and the proteasome inhibitor bortezomib (25 uM and 50 uM) for 4 h prior to lysis. DMSO was the vehicle control. Western blotting of whole-cell lysates revealed mSmoM2 protein to be destabilized in response to HSP-90 inhibitors but not in response to bortezomib. Tubulin was the loading control. CHOP results indicate ER stress.

    Mol Cell Biol 2013 33(12), 2375-87. Tanespimycin (17-AAG) purchased from Selleck.

  • Treatment with an Hsp90 inhibitor results in a dose-dependent decrease in complex IV activity. A, because Hsp90 levels were reduced by 80%, in PINK1 null dopaminergic neuronal cells, the effects of specific inhibition of Hsp90 using 17-AAG were analyzed in wild-type neuronal cells. Both complex IV activity and Hsp60 levels were decreased significantly in 17-AAG-treated cells in a dose-dependent manner. B, in contrast, 17-AAG treatment did not affect expression of Hsp90 and LRPPRC.

    J Biol Chem 2012 287, 44109-20. Tanespimycin (17-AAG) purchased from Selleck.

    SKBR3 cells were treated with FW-04-806 at 10, 20, 40 uM for 24 h; 17AAG was used as a positive control at 1 and 2 uM. Hsp70, Hsp90, and Cdc37 protein level were analyzed with western blotting using relevant antibodies.

    Mol Cancer 2014 13, 150. Tanespimycin (17-AAG) purchased from Selleck.

  • Hsp90 is up-regulated during aging. Whole-cell extracts were prepared from young (PD 20) and old (PD 40) HFSN1 cells. c HFSN1 cells (PD 40) were treated with different concentration of the Hsp90 inhibitor (17-AAG) and then re-incubated for 24 h. Whole-cell extracts were prepared and analyzed by western blot using the indicated antibodies.

    Age 2013 35, 549-62. Tanespimycin (17-AAG) purchased from Selleck.

Purity & Quality Control

Choose Selective HSP (e.g. HSP90) Inhibitors

Biological Activity

Description Tanespimycin (17-AAG) is a potent HSP90 inhibitor with IC50 of 5 nM in a cell-free assay, having a 100-fold higher binding affinity for HSP90 derived from tumour cells than HSP90 from normal cells. Phase 2.
Features Displays very low toxicity toward normal cells.
Targets
HSP90 [1]
(Cell-free assay)
5 nM
In vitro

17-AAG, an analog of geldanamycin, exhibits greater than 100 times higher binding affinity for Hsp90 derived from HER-2-overexpressing cancer cells (BT474, N87, SKOV3 and SKBR3) or BT474 breast carcinoma cells with IC50 values of 5-6 nM. [1] 17-AAG causes the degradation of HER2, HER3, Akt, and both mutant and wild-type androgen receptor (AR), leading to the RB-dependent G1 growth arrest of prostate cancer cells such as LNCaP, LAPC-4, DU-145, and PC-3 with IC50 values of 25-45 nM. [2] In addition to inducing apoptosis of Ba/F3 cells transformed with wild-type BCR-ABL with an IC50 of 5.2 μM, 17-AAG has the ability to induce apoptosis of cells transformed with imatinib mesylate-resistant T315I and E255K BCR-ABL mutants with IC50 values of 2.3 μM and 1.0 μM, respectively, by inducing the degradation of both wild-type BCR-ABL protein and mutants. [3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
A549 MlXNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV\JR|UxRTBwMECwN|A{KM7:TR?= MYLTRW5ITVJ?
IST-MEL1 M3jGNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV;JR|UxRTBwMECwOFA4KM7:TR?= M3nIW3NCVkeHUh?=
NCI-SNU-1 M3vUNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYTJR|UxRTBwMECyNFch|ryP MXfTRW5ITVJ?
FADU M3rmcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFzTTm9KSzVyPUCuNFAzODlizszN NH7xOGZUSU6JRWK=
C32 MlfTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkPCTWM2OD1yLkCwN|A1KM7:TR?= M3vTVnNCVkeHUh?=
D-566MG NX7jWVNZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4mwcmlEPTB;MD6wNFM6KM7:TR?= Mnn4V2FPT0WU
LXF-289 M3vjdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGDqRYxKSzVyPUCuNFA1OTlizszN NFjuNFRUSU6JRWK=
HGC-27 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVHJR|UxRTBwMEC1NUDPxE1? MmLZV2FPT0WU
RPMI-7951 Mk\FS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1u2OmlEPTB;MD6wNFcyPyEQvF2= MWXTRW5ITVJ?
HSC-3 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWDySZJHUUN3ME2wMlAxQTJ7IN88US=> NEeyXYxUSU6JRWK=
MIA-PaCa-2 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHrnSJpKSzVyPUCuNFExODlizszN MoDrV2FPT0WU
KS-1 Ml3SS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MonSTWM2OD1yLkCxN|U2KM7:TR?= NF3S[4JUSU6JRWK=
CAL-51 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWTiRWFEUUN3ME2wMlAyPDB3IN88US=> MX\TRW5ITVJ?
MDA-MB-361 NHPY[YtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mle3TWM2OD1yLkCxOFk2KM7:TR?= MlLXV2FPT0WU
TI-73 M{[2Xmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkfuTWM2OD1yLkCxO|k3KM7:TR?= MlLvV2FPT0WU
AGS NHXP[IdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVfCbW0zUUN3ME2wMlAyQTN6IN88US=> NXHqZo1SW0GQR1XS
NCI-H460 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFrLWHZKSzVyPUCuNFE6PzRizszN NI\6d4lUSU6JRWK=
A204 NUfHSWQxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHzvbYxKSzVyPUCuNFIzPDlizszN NH7MXmtUSU6JRWK=
CHL-1 M4TGcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4rGRmlEPTB;MD6wNlI2OSEQvF2= NV;qTHZ4W0GQR1XS
DU-4475 NEO4NHVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXzmc3V{UUN3ME2wMlAzOjZzIN88US=> NYXxWoJpW0GQR1XS
CGTH-W-1 M1G1Umdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NY\xTIRSUUN3ME2wMlAzOzR7IN88US=> NGnkToRUSU6JRWK=
HCC2218 NF3ocnFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlTxTWM2OD1yLkCyOFk1KM7:TR?= MmO2V2FPT0WU
A2780 NXL3dmI{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1PNd2lEPTB;MD6wNlU{OSEQvF2= NFH3TFJUSU6JRWK=
NCI-H720 MkDlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVzJR|UxRTBwMEK1OFYh|ryP NGLaT4VUSU6JRWK=
NCI-N87 MoPIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnnHTWM2OD1yLkCyOVk{KM7:TR?= NVnwOld7W0GQR1XS
CHP-212 NUDnV5BtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWTJR|UxRTBwMEK2Nlgh|ryP M2\aN3NCVkeHUh?=
NCI-H23 M13tS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVfnR|lnUUN3ME2wMlAzPjZ3IN88US=> NUfJT25tW0GQR1XS
D-263MG M4fITWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NImwVIxKSzVyPUCuNFI4QDZizszN M1fkOXNCVkeHUh?=
ME-180 M{LlXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVPJR|UxRTBwMEK4PVEh|ryP M{jpdnNCVkeHUh?=
SW982 M{XWSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NViwOGx2UUN3ME2wMlAzQTl7IN88US=> MYPTRW5ITVJ?
OE19 NWfHdopUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2j5SWlEPTB;MD6wN|A4PyEQvF2= M2SwWHNCVkeHUh?=
SK-LU-1 NGrCSWtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEC0TY1KSzVyPUCuNFMxQDJizszN M{\X[3NCVkeHUh?=
H4 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX62TVdEUUN3ME2wMlA{ODlizszN NGqzT5pUSU6JRWK=
HT-144 M{jDSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUPJR|UxRTBwMEOwPVMh|ryP NFXZXlJUSU6JRWK=
SK-UT-1 NF:3WXVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoLpTWM2OD1yLkCzNVc5KM7:TR?= NYfPW2lsW0GQR1XS
D-336MG NXXIdWFNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIPqe3JKSzVyPUCuNFM{ODlizszN NXrwSXd6W0GQR1XS
MDA-MB-175-VII NUe5eIE{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIPucG1KSzVyPUCuNFM{PTRizszN NGjaSoFUSU6JRWK=
GAMG NIT4fHdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXPJR|UxRTBwMEO0N|Uh|ryP NYTkUZBmW0GQR1XS
CP50-MEL-B NU[5SoY1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NETIRYdKSzVyPUCuNFM1PSEQvF2= NXzWVZpCW0GQR1XS
OVCAR-5 NXTqVlF7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYrJR|UxRTBwMEO0PEDPxE1? Mny5V2FPT0WU
SK-MES-1 NVy1c4pqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{P4eWlEPTB;MD6wN|YxPiEQvF2= MmniV2FPT0WU
VM-CUB-1 NIjEZZZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4jnWGlEPTB;MD6wN|Y2PyEQvF2= MmW3V2FPT0WU
WM-115 NHHDW5RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3HEdGlEPTB;MD6wN|c3OiEQvF2= NYj3SndpW0GQR1XS
DSH1 NInpUohIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M121N2lEPTB;MD6wN|gxPyEQvF2= MV3TRW5ITVJ?
Becker NYWxclhOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXznbm42UUN3ME2wMlA{QDh3IN88US=> M3K1SHNCVkeHUh?=
SW962 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGXwPWJKSzVyPUCuNFM6PDVizszN MmHiV2FPT0WU
TYK-nu M3PFUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2i2S2lEPTB;MD6wN|k5PSEQvF2= NFnBZohUSU6JRWK=
HO-1-N-1 NIn3SFJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYTvUos5UUN3ME2wMlA1ODJzIN88US=> MlnLV2FPT0WU
T98G MoXkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYj1VJJtUUN3ME2wMlA1OTB|IN88US=> MWTTRW5ITVJ?
ACN Mn7BS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M125VWlEPTB;MD6wOFE3OiEQvF2= M4nHe3NCVkeHUh?=
SW780 NFfGPXdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV;JR|UxRTBwMESyNFMh|ryP Mlj0V2FPT0WU
Detroit562 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4fYbmlEPTB;MD6wOFI{QSEQvF2= NHH5dnhUSU6JRWK=
BB49-HNC M4\FVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{HUeWlEPTB;MD6wOFI1OyEQvF2= NHHwW|hUSU6JRWK=
HN NGS5WIdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFPJW|RKSzVyPUCuNFQzPzJizszN MmPNV2FPT0WU
H9 Mle2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXjESGlCUUN3ME2wMlA1OzdzIN88US=> M2nlU3NCVkeHUh?=
VA-ES-BJ MoHVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX\oeVhNUUN3ME2wMlA1PDR5IN88US=> M3OyUHNCVkeHUh?=
MEL-JUSO MljGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUnJR|UxRTBwMES0O|Uh|ryP MlK0V2FPT0WU
BT-474 MkizS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3vLeGlEPTB;MD6wOFUh|ryP MXvTRW5ITVJ?
CaR-1 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M330PGlEPTB;MD6wOFU1QSEQvF2= MXfTRW5ITVJ?
PSN1 NFP6[|NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mk\4TWM2OD1yLkC0OlA{KM7:TR?= M32yNHNCVkeHUh?=
KYSE-510 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV7zOJhYUUN3ME2wMlA1PjR7IN88US=> MUPTRW5ITVJ?
KP-4 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIr1NWtKSzVyPUCuNFQ4PTNizszN NEDaZYVUSU6JRWK=
KYSE-410 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV;JR|UxRTBwMES3O|Ih|ryP Ml;uV2FPT0WU
G-402 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoLzTWM2OD1yLkC0O|g6KM7:TR?= NFWwTZdUSU6JRWK=
DOK MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWjCdnpPUUN3ME2wMlA1QTB{IN88US=> MVjTRW5ITVJ?
COR-L88 NHrmZXZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MULJR|UxRTBwMES5NVIh|ryP MWnTRW5ITVJ?
SKG-IIIa MkOxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlL2TWM2OD1yLkC0PVg3KM7:TR?= NVfiT29jW0GQR1XS
AN3-CA M1fs[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWHJR|UxRTBwMEWg{txO MXPTRW5ITVJ?
SW48 NHqxfZpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXzP[IdTUUN3ME2wMlA2ODN7IN88US=> MnHEV2FPT0WU
YKG-1 Mn;lS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoPZTWM2OD1yLkC1NFcyKM7:TR?= NW\SU|c6W0GQR1XS
KYSE-150 MoSxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2m4SWlEPTB;MD6wOVI{PSEQvF2= MmLEV2FPT0WU
HuO-3N1 M{e5U2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWnJR|UxRTBwMEWyN|ch|ryP M4O4W3NCVkeHUh?=
LB1047-RCC MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUTJR|UxRTBwMEWyPVYh|ryP NWHqdY5tW0GQR1XS
NCI-H2030 MoHtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2HnXWlEPTB;MD6wOVQyPCEQvF2= NIXFbGJUSU6JRWK=
YH-13 NXTWeYFpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVnJR|UxRTBwMEW3NlIh|ryP NEHUR21USU6JRWK=
5637 NXjkO2VRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYjmTlNOUUN3ME2wMlA2PzRizszN M3LkNnNCVkeHUh?=
LOXIMVI NXrVPI5KT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV7pW5VVUUN3ME2wMlA2QDd{IN88US=> NY[1bJZDW0GQR1XS
GT3TKB MmfaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1TNemlEPTB;MD6wOVk1OiEQvF2= NHL5UWVUSU6JRWK=
TCCSUP MmPaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVHJR|UxRTBwMEW5OlQh|ryP M2H6NnNCVkeHUh?=
EPLC-272H MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFzZeZhKSzVyPUCuNFYzODVizszN NUO0d4dSW0GQR1XS
LU-99A M1HSPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2Tle2lEPTB;MD6wOlI{PyEQvF2= NWKySlVoW0GQR1XS
NCI-H1755 NXrudY55T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYPJR|UxRTBwME[zOFEh|ryP NHXJd4RUSU6JRWK=
KM12 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{XKeGlEPTB;MD6wOlM1QCEQvF2= MWHTRW5ITVJ?
SF295 NFPQXGdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYD1SlE2UUN3ME2wMlA3PDV{IN88US=> NVX3WG5UW0GQR1XS
MZ2-MEL MnvDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3vi[WlEPTB;MD6wOlU2OyEQvF2= MXfTRW5ITVJ?
HEC-1 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoXSTWM2OD1yLkC2OVg5KM7:TR?= NX7ucYRIW0GQR1XS
SW684 M3riUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoO3TWM2OD1yLkC2OVkyKM7:TR?= NUDxdItKW0GQR1XS
SF539 M3fuWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXrJR|UxRTBwME[2PFEh|ryP NWXMW21YW0GQR1XS
GMS-10 NFvQcI9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF3WUYNKSzVyPUCuNFY3QTlizszN M{nydHNCVkeHUh?=
MV-4-11 NHTaZ3BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlLDTWM2OD1yLkC2PFA{KM7:TR?= MV7TRW5ITVJ?
HT-29 NWLKZpBOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFnhVHJKSzVyPUCuNFY6OTlizszN MX;TRW5ITVJ?
23132-87 NUT0VGd4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHHUflRKSzVyPUCuNFY6PSEQvF2= MkXrV2FPT0WU
SW620 MnXkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWjGb5JIUUN3ME2wMlA4ODJ4IN88US=> M3v6fXNCVkeHUh?=
HCC1806 MmXBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mle3TWM2OD1yLkC3NVMyKM7:TR?= NF\G[lhUSU6JRWK=
Hs-578-T NFS3VpBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIrvOppKSzVyPUCuNFczODhizszN MWnTRW5ITVJ?
A2058 NULWeIJDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlmzTWM2OD1yLkC3NlI5KM7:TR?= M3\0c3NCVkeHUh?=
MEL-HO NVTLeJpHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF;yd25KSzVyPUCuNFczPTVizszN NULLe4p1W0GQR1XS
HCC2998 M4DadWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2r0SWlEPTB;MD6wO|M1PyEQvF2= MY\TRW5ITVJ?
HuO9 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFnDZphKSzVyPUCuNFc2QDlizszN NFLOfppUSU6JRWK=
CAL-39 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYHkeVhGUUN3ME2wMlA4PzZ4IN88US=> MoLqV2FPT0WU
M14 NITqeYJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVHJR|UxRTBwMEe5NVMh|ryP NFnTdlBUSU6JRWK=
BFTC-909 M1HBUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXnJR|UxRTBwMEe5Olkh|ryP MknZV2FPT0WU
TE-11 NEn4WlZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MorxTWM2OD1yLkC3PVk3KM7:TR?= MknhV2FPT0WU
TGBC1TKB NFPBRlhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXvy[pIxUUN3ME2wMlA5ODR|IN88US=> NVLnd3hYW0GQR1XS
L-363 NV6xW|c5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWDT[mFGUUN3ME2wMlA5OjB4IN88US=> MmDBV2FPT0WU
A431 NW\WdVkyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFO5eo9KSzVyPUCuNFgzOSEQvF2= M37VfnNCVkeHUh?=
MKN45 NX7pdI8yT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mnr2TWM2OD1yLkC4NlE6KM7:TR?= NX3HOll7W0GQR1XS
HT-1080 NWTnb3JmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWrJR|UxRTBwMEi0N|kh|ryP NGjqWWRUSU6JRWK=
OVCAR-8 NGHtXZFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX;6XFNlUUN3ME2wMlA5PjJ{IN88US=> NFrj[2VUSU6JRWK=
LCLC-97TM1 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFf6SXBKSzVyPUCuNFg4OjhizszN M3SxRXNCVkeHUh?=
M059J MlvPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmPDTWM2OD1yLkC5NFI4KM7:TR?= M3LpWnNCVkeHUh?=
SK-MEL-2 Mn\WS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3HLeGlEPTB;MD6wPVA3KM7:TR?= MnTEV2FPT0WU
TE-1 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXnJR|UxRTBwMEmyNFQh|ryP MkjtV2FPT0WU
KYSE-180 MmPyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVfJR|UxRTBwMEmyOlIh|ryP Mn\wV2FPT0WU
D-247MG NYDOdpRXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M17X[WlEPTB;MD6wPVQ2PSEQvF2= M4e2Z3NCVkeHUh?=
8-MG-BA M336R2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mlr4TWM2OD1yLkC5OFczKM7:TR?= NFLIZpRUSU6JRWK=
NCI-H1792 NV7CNVdJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXPGbW1MUUN3ME2wMlA6PjF6IN88US=> M4\k[HNCVkeHUh?=
MCF7 NXHlSVVxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVfJR|UxRTBwMEm2O|ch|ryP NUDIdJI5W0GQR1XS
NCI-H2122 MnfCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4Tn[2lEPTB;MD6wPVc1PSEQvF2= NHjobnZUSU6JRWK=
EFO-27 M3q5bWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHXnd45KSzVyPUCuNFk6QTdizszN NHLrS|FUSU6JRWK=
LB2241-RCC NX;3SYc{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV3JR|UxRTBwMUCwOVQh|ryP MYDTRW5ITVJ?
SN12C MmrGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoL6TWM2OD1yLkGwNVA4KM7:TR?= M4f1fnNCVkeHUh?=
A498 M{n5[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkjYTWM2OD1yLkGwNVgh|ryP NETQW2JUSU6JRWK=
PANC-03-27 M2Hh[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFiwWXhKSzVyPUCuNVAzQDZizszN Moe2V2FPT0WU
NCI-H1581 NVvVelhOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUXJR|UxRTBwMUCyPUDPxE1? MX3TRW5ITVJ?
U-87-MG MonlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmD0TWM2OD1yLkGwN|A4KM7:TR?= M4HKXnNCVkeHUh?=
G-401 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MW\JR|UxRTBwMUCzOVMh|ryP MWHTRW5ITVJ?
SiHa NYHuW5diT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1flUGlEPTB;MD6xNFQ5PiEQvF2= NYTySJNbW0GQR1XS
U251 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnHsTWM2OD1yLkGwOVI2KM7:TR?= Mmm1V2FPT0WU
MMAC-SF Mk\GS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUnJR|UxRTBwMUC1N|Eh|ryP M1nlNXNCVkeHUh?=
BB65-RCC MnjJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mle1TWM2OD1yLkGwOVU1KM7:TR?= NEDNRYVUSU6JRWK=
NKM-1 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXzwWnd1UUN3ME2wMlExPjZ4IN88US=> MUnTRW5ITVJ?
HD-MY-Z NUD6TW1jT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkfwTWM2OD1yLkGwPFc{KM7:TR?= NXm2UXVrW0GQR1XS
TGBC11TKB NELXZXFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXHJR|UxRTBwMUC5NFMh|ryP MX7TRW5ITVJ?
COLO-679 NFTt[WdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVLyWIxlUUN3ME2wMlEyOjFzIN88US=> MmXEV2FPT0WU
TE-8 MnjmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmHzTWM2OD1yLkGxNlY1KM7:TR?= MkTlV2FPT0WU
SK-MEL-28 MnPmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVHJR|UxRTBwMUGzNlEh|ryP MXTTRW5ITVJ?
SH-4 NULoSJM6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mkj3TWM2OD1yLkGxN|U3KM7:TR?= MUTTRW5ITVJ?
KALS-1 M3S5U2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnroTWM2OD1yLkGxN|k{KM7:TR?= M{nRdnNCVkeHUh?=
RKO MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUftZ|A6UUN3ME2wMlEyPzZ2IN88US=> MkXsV2FPT0WU
OMC-1 NUXLfZBbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXTtd3N5UUN3ME2wMlEyPzl5IN88US=> NH7rZ5ZUSU6JRWK=
BT-549 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MonBTWM2OD1yLkGxO|k6KM7:TR?= NEfHfVhUSU6JRWK=
NCI-H28 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGLVdmtKSzVyPUCuNVE5OTdizszN M1\mT3NCVkeHUh?=
RXF393 NH;Vc|VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUfodXY2UUN3ME2wMlEyQTh{IN88US=> MV;TRW5ITVJ?
COLO-829 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXPFRVJHUUN3ME2wMlEzODB3IN88US=> NWrMNXdLW0GQR1XS
HMV-II NXyySoh3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXnJR|UxRTBwMUKwNkDPxE1? MXnTRW5ITVJ?
SW1990 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX;pR|V6UUN3ME2wMlEzOTV5IN88US=> NXrkSZd3W0GQR1XS
NCI-H1437 NIP4b3hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUfJR|UxRTBwMUKxOVch|ryP MmruV2FPT0WU
SNB75 NYnuVZJvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX7lc5VbUUN3ME2wMlEzOTZ7IN88US=> NX:4eox6W0GQR1XS
EW-3 NHTVPWpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MomwTWM2OD1yLkGyOlYyKM7:TR?= NV7VR|NEW0GQR1XS
SAS MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF\seoFKSzVyPUCuNVI3QSEQvF2= NIDxbopUSU6JRWK=
NCI-H1666 NW\aUGN5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3vkdmlEPTB;MD6xNlc4PCEQvF2= M1T5SXNCVkeHUh?=
A375 NGTmTJNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{DSTWlEPTB;MD6xNlc4QCEQvF2= MknTV2FPT0WU
CAMA-1 NUHV[Y5ZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXHJR|UxRTBwMUK5NlQh|ryP Mn\vV2FPT0WU
HuP-T4 NVTiUWx3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmDFTWM2OD1yLkGyPVQ{KM7:TR?= MoPEV2FPT0WU
NCI-H292 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFLrPYhKSzVyPUCuNVMyOSEQvF2= M3j1UnNCVkeHUh?=
PC-14 NW\ONnY6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2H5b2lEPTB;MD6xN|IyOSEQvF2= MVjTRW5ITVJ?
BPH-1 NFT3bHZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mo[2TWM2OD1yLkGzOFEh|ryP M2fkdnNCVkeHUh?=
GAK MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGrIfGlKSzVyPUCuNVM2PjdizszN NF7aSpRUSU6JRWK=
VMRC-RCZ NH6xdGVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2LSWmlEPTB;MD6xN|c3OiEQvF2= NEDt[nZUSU6JRWK=
SK-MEL-24 NIC3R|ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGjzeldKSzVyPUCuNVM5PyEQvF2= MVPTRW5ITVJ?
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NCI-H2452 NGHFWWdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1PFfGlEPTB;MD6xN|k2PiEQvF2= MmPTV2FPT0WU
RT-112 Mm\QS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NES0NGNKSzVyPUCuNVQxOzVizszN M3LhbHNCVkeHUh?=
GP5d M4nMfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH\Ecm9KSzVyPUCuNVQyODRizszN NF3CTZlUSU6JRWK=
LC-2-ad M2juR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoXpTWM2OD1yLkG0NVIyKM7:TR?= MnmzV2FPT0WU
MPP-89 NX6xTZhiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGP6XopKSzVyPUCuNVQyOjVizszN NGTpUZBUSU6JRWK=
NUGC-3 NFjQVJRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH:4N|BKSzVyPUCuNVQ1PzhizszN NELrUGxUSU6JRWK=
GI-1 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4\TbGlEPTB;MD6xOFU2QCEQvF2= NUfJXYR1W0GQR1XS
HCC1419 MkjrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWCxOGZbUUN3ME2wMlE1PTd4IN88US=> M{HHdnNCVkeHUh?=
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NCI-H2347 NGTGXWpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnW2TWM2OD1yLkG0PFM6KM7:TR?= M4\kfXNCVkeHUh?=
Mewo MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUDJR|UxRTBwMUS4PFkh|ryP NHy3fXhUSU6JRWK=
639-V M4C5PWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MW\JR|UxRTBwMUWwNVMh|ryP MoLBV2FPT0WU
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NCI-H1648 NEXqdFBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXPoR2NlUUN3ME2wMlE2OjN{IN88US=> NYDWdmIzW0GQR1XS
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ETK-1 NHPoOWdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1yw[mlEPTB;MD6xOVkh|ryP MkXoV2FPT0WU
BxPC-3 M125[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnzrTWM2OD1yLkG1PVY3KM7:TR?= M4Swc3NCVkeHUh?=
CAL-62 NV;ucFFQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnzyTWM2OD1yLkG2NVY6KM7:TR?= MV;TRW5ITVJ?
HCC1937 NFHWelNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXfJR|UxRTBwMU[yO|Uh|ryP MnXyV2FPT0WU
NCI-H1299 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXTJR|UxRTBwMU[yPFUh|ryP M1rZSXNCVkeHUh?=
SW1088 NWP2SIpZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF3TSHFKSzVyPUCuNVY1OTNizszN NGjpPG5USU6JRWK=
FTC-133 Mle4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV3vZ3N5UUN3ME2wMlE3PTRizszN MnfxV2FPT0WU
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SCC-9 NGLTUY5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYnGO4Z[UUN3ME2wMlE3PzF4IN88US=> M4fXOHNCVkeHUh?=
HT-1376 M{fn[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUfJR|UxRTBwMU[5N|Yh|ryP NHvndm9USU6JRWK=
U-2-OS M2rzfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NY\iVmtQUUN3ME2wMlE4OTd|IN88US=> M4LTSHNCVkeHUh?=
COLO-824 MnvnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUT4TnY5UUN3ME2wMlE4Ojl2IN88US=> Ml24V2FPT0WU
BB30-HNC MkDCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmrwTWM2OD1yLkG3N|Mh|ryP M2\NR3NCVkeHUh?=
NCI-H2087 NHH4bnVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn7KTWM2OD1yLkG3N|Y5KM7:TR?= MXTTRW5ITVJ?
NCI-H2170 M1ewXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFnFTZJKSzVyPUCuNVc2OzZizszN NFLQS2NUSU6JRWK=
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MZ7-mel M1;uPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV;JR|UxRTBwMUe2OFkh|ryP NYT2S2RDW0GQR1XS
NCI-H650 M{HGNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MofaTWM2OD1yLkG3OlgzKM7:TR?= M2i4W3NCVkeHUh?=
KOSC-2 M3K2T2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHjvNWJKSzVyPUCuNVc4OzRizszN M3TKRnNCVkeHUh?=
SCC-4 NVzzUWc1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUDJR|UxRTBwMUe3O|ch|ryP NHzhTlNUSU6JRWK=
MDA-MB-157 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1;4UmlEPTB;MD6xPFA5OiEQvF2= MV3TRW5ITVJ?
KYSE-520 NVzj[|hOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2rKOWlEPTB;MD6xPFIh|ryP NWfvRlA{W0GQR1XS
LK-2 NFL6[lJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUXYWW9sUUN3ME2wMlE5OzB|IN88US=> MXTTRW5ITVJ?
KNS-81-FD NYHCTmFrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmXWTWM2OD1yLkG4N|k1KM7:TR?= MYXTRW5ITVJ?
IGROV-1 M1zxPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV;Oc4VwUUN3ME2wMlE5PDR|IN88US=> M3TVenNCVkeHUh?=
DEL Mlm4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGDW[oNKSzVyPUCuNVg1PSEQvF2= NGj3bGNUSU6JRWK=
NCI-H1395 M2rPXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2ezdmlEPTB;MD6xPFY5OiEQvF2= NGXTU5dUSU6JRWK=
JEG-3 NFW2U5BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnrDTWM2OD1yLkG4O|A2KM7:TR?= MVjTRW5ITVJ?
BCPAP M{jmUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkDmTWM2OD1yLkG4PFczKM7:TR?= NVS5VXdLW0GQR1XS
CAL-27 NUnnXlR3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV;ReVd1UUN3ME2wMlE6ODJ{IN88US=> NG[y[4ZUSU6JRWK=
RD MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{O5RmlEPTB;MD6xPVEyOyEQvF2= NHPBboxUSU6JRWK=
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COLO-680N MkDlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml7YTWM2OD1yLkG5N|Y1KM7:TR?= MVPTRW5ITVJ?
NCI-H1650 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXXJR|UxRTBwMkCwOVch|ryP NXzuXJdnW0GQR1XS
SBC-5 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1LON2lEPTB;MD6yNFEyQCEQvF2= MXzTRW5ITVJ?
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S-117 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoHOTWM2OD1yLkKwOVY1KM7:TR?= NXHq[YxxW0GQR1XS
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AM-38 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXXCVZVIUUN3ME2wMlIxQDR6IN88US=> NX;KSYtGW0GQR1XS
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HPAF-II M2rQdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYjJR|UxRTBwMkGyOlQh|ryP M{fqcHNCVkeHUh?=
769-P NXnzPHQyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MULJR|UxRTBwMkGyPEDPxE1? NEn5RpBUSU6JRWK=
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SCC-25 Mn3vS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWLYWo9EUUN3ME2wMlI1PTZ|IN88US=> M1TOUHNCVkeHUh?=
CAPAN-1 MnLQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYnJR|UxRTBwMkS3PFMh|ryP NH3ESGdUSU6JRWK=
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TE-6 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX;JR|UxRTBwMkW3OUDPxE1? MlPJV2FPT0WU
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NCI-H1155 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYf2cGIxUUN3ME2wMlI3OTZ{IN88US=> M4PUbXNCVkeHUh?=
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HTC-C3 MnT2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVXzdHdvUUN3ME2wMlI3PTB4IN88US=> NUD3cnlHW0GQR1XS
HCT-116 MmOxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{DUc2lEPTB;MD6yOlU6QSEQvF2= Mn:zV2FPT0WU
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NB69 MlGxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHm4OpdKSzVyPUCuNlcxQDdizszN NYfjSolYW0GQR1XS
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NCI-H1355 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXjJR|UxRTBwMkiwO|Qh|ryP MWLTRW5ITVJ?
NCI-H1048 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1P4eWlEPTB;MD6yPFk2PiEQvF2= MVHTRW5ITVJ?
SW954 NGDmV3lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mlm5TWM2OD1yLkK5NlI4KM7:TR?= MXTTRW5ITVJ?
NMC-G1 Ml3TS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MljoTWM2OD1yLkK5Nlc4KM7:TR?= MkfXV2FPT0WU
SW1710 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmXBTWM2OD1yLkK5OFk1KM7:TR?= MojMV2FPT0WU
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BFTC-905 M2Dtbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnjETWM2OD1yLkOxOVIyKM7:TR?= M{jl[HNCVkeHUh?=
ChaGo-K-1 NHzJVpFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHL0cXJKSzVyPUCuN|E4OTVizszN MV\TRW5ITVJ?
Daoy MlniS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn;YTWM2OD1yLkOxO|I{KM7:TR?= NXH6e|dQW0GQR1XS
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KNS-62 M4HEe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUnkZZVEUUN3ME2wMlMzODh6IN88US=> MkPwV2FPT0WU
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UACC-62 M{K5XGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mk\STWM2OD1yLkOyNlI4KM7:TR?= NHWyU21USU6JRWK=
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CTB-1 NGXPcolIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYjJR|UxRTBwM{K3OVMh|ryP NW[3[5ZKW0GQR1XS
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T-24 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NInkPWFKSzVyPUCuN|MyPTlizszN MWrTRW5ITVJ?
KYSE-70 MmfSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnTaTWM2OD1yLkOzNlg{KM7:TR?= M2TacXNCVkeHUh?=
SW626 MnW2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYfJR|UxRTBwM{O1N|Ih|ryP MlXkV2FPT0WU
LB996-RCC MnHZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX3GNVU3UUN3ME2wMlM{PjF7IN88US=> NXLDUm1wW0GQR1XS
DMS-273 MkOwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYLpPIhUUUN3ME2wMlM{QTF4IN88US=> MYXTRW5ITVJ?
SW1783 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{n2PGlEPTB;MD6zN|k6PyEQvF2= MlfFV2FPT0WU
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HSC-2 M1\xS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4T1b2lEPTB;MD6zOFA2OyEQvF2= NVPROnV7W0GQR1XS
A3-KAW MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3;hV2lEPTB;MD6zOFE3OiEQvF2= M4HPdHNCVkeHUh?=
COLO-684 MkXWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF\YT|NKSzVyPUCuN|Q2ODFizszN M4PWOnNCVkeHUh?=
NCI-H2405 M3fu[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlLvTWM2OD1yLkO0OlMyKM7:TR?= NEXoSXZUSU6JRWK=
NCI-H2228 MnHPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUDJNXk4UUN3ME2wMlM2OzV5IN88US=> MYDTRW5ITVJ?
NB13 NYTaeVBnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{PJRmlEPTB;MD6zOlgzQSEQvF2= M3nFc3NCVkeHUh?=
no-11 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnG3TWM2OD1yLkO2PVUh|ryP NHyxc2VUSU6JRWK=
DK-MG MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{\4U2lEPTB;MD6zO|E5QCEQvF2= Mn\jV2FPT0WU
NBsusSR NF\l[2lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1;rS2lEPTB;MD6zO|I5PSEQvF2= M3TyRnNCVkeHUh?=
KP-N-YS NV3wfItbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUXPcpBmUUN3ME2wMlM4PDZ|IN88US=> MUTTRW5ITVJ?
CFPAC-1 NWD0Z3JnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUHoZoxnUUN3ME2wMlM4PTF6IN88US=> MnX5V2FPT0WU
KARPAS-45 M4fGOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MW\JR|UxRTBwM{e4OlIh|ryP NFXnPG1USU6JRWK=
NCI-H1793 M{f0SGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mk\CTWM2OD1yLkO4OVEh|ryP NH\Ve5dUSU6JRWK=
HCE-T NYT3enhPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYrBPJNlUUN3ME2wMlM5PjB|IN88US=> M3;YPXNCVkeHUh?=
NCI-H520 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3[5eGlEPTB;MD6zPFcxOyEQvF2= NXq4OYJPW0GQR1XS
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EW-18 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUnG[VduUUN3ME2wMlM5QTRzIN88US=> M2\ieXNCVkeHUh?=
RO82-W-1 NH6wZnlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2e1R2lEPTB;MD6zPVY6QSEQvF2= NV7vb5ZnW0GQR1XS
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PANC-10-05 MnnxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHPibYpKSzVyPUCuOFEyPyEQvF2= MVrTRW5ITVJ?
NCI-H1703 M{\5Smdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXGxNYZFUUN3ME2wMlQyPDR4IN88US=> MUfTRW5ITVJ?
TE-10 NWfacndKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHO0OmhKSzVyPUCuOFE1PDdizszN NE\zeYVUSU6JRWK=
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LN-405 NXP1eVlmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV:0WXZQUUN3ME2wMlQyPjh5IN88US=> MnfSV2FPT0WU
A427 NGH5U4tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUHpZoxIUUN3ME2wMlQyQThzIN88US=> MWTTRW5ITVJ?
CAL-12T M4DlOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mk\WTWM2OD1yLkSyO|gh|ryP M2jFSXNCVkeHUh?=
SW756 NInEW2hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWDJR|UxRTBwNESxPFMh|ryP Moi0V2FPT0WU
YAPC NVXXe497T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoKxTWM2OD1yLkS1NFgh|ryP Mkm4V2FPT0WU
GOTO MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml;TTWM2OD1yLkS1NVYh|ryP MW\TRW5ITVJ?
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UM-UC-3 NFLVWm9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFXIUVVKSzVyPUCuOFU1PyEQvF2= NF3USZBUSU6JRWK=
NCI-H1573 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWTme3VEUUN3ME2wMlQ2PTZ7IN88US=> MUXTRW5ITVJ?
LS-411N NHK0S3ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MU\JR|UxRTBwNE[1Nlch|ryP NIDaeVFUSU6JRWK=
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HCE-4 NV7OU5lvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{SzemlEPTB;MD60O|Q1PiEQvF2= Mn[yV2FPT0WU
NCI-H2291 Mm\NS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUHnSldsUUN3ME2wMlQ4QDl4IN88US=> MWHTRW5ITVJ?
A101D M3nXN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4[3ZWlEPTB;MD60PFA2OyEQvF2= M{PGc3NCVkeHUh?=
HT-3 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmrLTWM2OD1yLkS4NlE4KM7:TR?= MXzTRW5ITVJ?
HOP-62 M1HlUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF7rNWNKSzVyPUCuOFk5PjVizszN MYPTRW5ITVJ?
PC-3 NEHNcZRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUfJR|UxRTBwNUG1NFch|ryP MnzpV2FPT0WU
CTV-1 M2TFNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3q5WWlEPTB;MD61NlY3QSEQvF2= NHTQTYxUSU6JRWK=
PANC-08-13 NGHhdYFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoqyTWM2OD1yLkWzNVc4KM7:TR?= NYTuRnpRW0GQR1XS
CAL-120 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmX2TWM2OD1yLkWzN|k6KM7:TR?= MYnTRW5ITVJ?
UMC-11 M3nybWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV\UXlhQUUN3ME2wMlU2OjN2IN88US=> NYf3XHVPW0GQR1XS
MSTO-211H M1vGUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV31[5B{UUN3ME2wMlU2PzZ{IN88US=> M1PEUHNCVkeHUh?=
NCI-H2126 M3jQVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUnJR|UxRTBwNU[4NVUh|ryP M3m2N3NCVkeHUh?=
SNU-C2B MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUnJR|UxRTBwNUe5O|ch|ryP NULKUZljW0GQR1XS
DBTRG-05MG MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3XabWlEPTB;MD61PFA2OyEQvF2= NUfje4MyW0GQR1XS
MKN1 NIDzTG1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV34N4lvUUN3ME2wMlU5Pzh|IN88US=> M{\aN3NCVkeHUh?=
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OVCAR-3 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFXxTIZKSzVyPUCuOVk{PDFizszN MorDV2FPT0WU
ACHN NHfvfWdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUPJR|UxRTBwNkC1Olkh|ryP Mm\OV2FPT0WU
SW872 Ml3OS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUn0Wop3UUN3ME2wMlYxPzZ|IN88US=> M1fFeHNCVkeHUh?=
CP66-MEL NV;qPHB[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoTYTWM2OD1yLk[wPVY6KM7:TR?= NXPSWWVoW0GQR1XS
NCI-H661 NXm3NZZvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUjHVo1MUUN3ME2wMlYyOTB2IN88US=> Ml7MV2FPT0WU
UACC-893 M3\uZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnTqTWM2OD1yLk[zOlgyKM7:TR?= M1XXcHNCVkeHUh?=
JVM-3 NGj0VYxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkfGTWM2OD1yLk[zPFA1KM7:TR?= NX\VbVh4W0GQR1XS
SF268 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmLWTWM2OD1yLk[0N|Q6KM7:TR?= NXjpOpNCW0GQR1XS
OCI-AML2 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlLjTWM2OD1yLk[1N|k4KM7:TR?= MYfTRW5ITVJ?
RPMI-8226 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVm1c2l6UUN3ME2wMlY3OzJ|IN88US=> MmLTV2FPT0WU
MKN28 MknMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmW1TWM2OD1yLk[2OlI1KM7:TR?= NGTLSG9USU6JRWK=
MDA-MB-453 NFrxSVlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYPJR|UxRTBwNkexPEDPxE1? M37QWHNCVkeHUh?=
BV-173 NEG2XoZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NG\vbZBKSzVyPUCuOlg3PzlizszN MojGV2FPT0WU
NCI-H358 NIe4V2FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3rJfmlEPTB;MD62PFczPiEQvF2= MXLTRW5ITVJ?
NCI-H1651 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmTnTWM2OD1yLkeg{txO MXrTRW5ITVJ?
MDA-MB-415 NHnjUVRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4i4cGlEPTB;MD63NFgzQSEQvF2= M2PEb3NCVkeHUh?=
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MKN7 M{Lkd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWLJR|UxRTFyLkm3OlUh|ryP Mn:3V2FPT0WU
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ES7 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NE\xRVhKSzVyPUGxMlM{OTNizszN MXHTRW5ITVJ?
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BEN M3jMTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXvJR|UxRTFzLki1NUDPxE1? M3\US3NCVkeHUh?=
NCI-H1770 MmWyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIrlPVZKSzVyPUGyMlEzPiEQvF2= M4fNU3NCVkeHUh?=
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Mo-T MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUHJR|UxRTF{Lke0NlEh|ryP MVLTRW5ITVJ?
HLE MnnNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFXnNGZKSzVyPUGyMlgzOTVizszN MXfTRW5ITVJ?
RCC10RGB MoLwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWHSdYxuUUN3ME2xN{43PzFizszN MoPiV2FPT0WU
COLO-320-HSR M3v4XGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NELESWFKSzVyPUGzMlc{QDFizszN NEXNNpJUSU6JRWK=
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OCUB-M MlywS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXHJR|UxRTF2LkG2NFIh|ryP MUjTRW5ITVJ?
MEG-01 M4HLXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnfwTWM2OD1zND6zO|A5KM7:TR?= NYHxVJVWW0GQR1XS
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NCI-H1304 M{fZWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NELRZ5JKSzVyPUG1MlA1OjVizszN NIm5VIRUSU6JRWK=
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NCI-H2342 NVrFXYU6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml20TWM2OD1zNT6yNFQ1KM7:TR?= NH[0TFFUSU6JRWK=
LAN-6 NUfRfXROT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXjJR|UxRTF3LkS0NVQh|ryP NYLST5VXW0GQR1XS
JVM-2 NYLYS5VNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXL0[FltUUN3ME2xOU42PzR6IN88US=> MoXXV2FPT0WU
P30-OHK M3ftfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn\iTWM2OD1zNj6wOlE1KM7:TR?= NHvqfZlUSU6JRWK=
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RPMI-8866 NY\W[WM{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mm\lTWM2OD1zNj64OFk3KM7:TR?= NWG2e4VuW0GQR1XS
NCI-H630 NGWwV5pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M33pb2lEPTB;MU[uPFU{PyEQvF2= NW\yeppkW0GQR1XS
KYSE-140 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV21bJZ7UUN3ME2xO{4zODJ6IN88US=> NHrHc3dUSU6JRWK=
T84 M3;aTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFnWdIJKSzVyPUG4Mlg3QTVizszN MWLTRW5ITVJ?
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BALL-1 NIPWRVVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVLJR|UxRTF7LkOzPVkh|ryP MmK1V2FPT0WU
Calu-6 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkXwTWM2OD1zOT60PVIh|ryP MoG4V2FPT0WU
EGI-1 MoXBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoDHTWM2OD1zOT61PVgh|ryP NUHHUnEyW0GQR1XS
MFH-ino NH6zUZdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUG3eGJGUUN3ME2xPU44PDV2IN88US=> NH3KbplUSU6JRWK=
GB-1 M1zKRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUjJR|UxRTJyLkO1N|Uh|ryP NVO5dFBiW0GQR1XS
NCI-H1693 MkTWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFnS[5JKSzVyPUKwMlY2ODVizszN MXnTRW5ITVJ?
SW1116 M4facmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWG0fndoUUN3ME2yNE46OzZ{IN88US=> NUHTfmNJW0GQR1XS
H-EMC-SS NXfkZlhiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoOxTWM2OD1{Mj6wOFUh|ryP NE[4d4VUSU6JRWK=
D-502MG NEn3SHNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NU\EZ3pJUUN3ME2yNk45OjZzIN88US=> NHnW[3ZUSU6JRWK=
IA-LM M4PD[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoTGTWM2OD1{Mz6yOFk{KM7:TR?= NF;sNmlUSU6JRWK=
SW1463 NIfCSo5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlTRTWM2OD1{Mz63PUDPxE1? NHq0c4pUSU6JRWK=
JAR MkLnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUfyRWpjUUN3ME2yOE4{Ojl|IN88US=> NWHZWXdrW0GQR1XS
HT MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NW\pWXFCUUN3ME2yOE41PzV|IN88US=> MlLmV2FPT0WU
LCLC-103H NH[yV4hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWnJR|UxRTJ2Lki0OFkh|ryP NVGzc49MW0GQR1XS
SNU-449 NEftcYVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mlv6TWM2OD1{ND64O|QyKM7:TR?= MVrTRW5ITVJ?
KE-37 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX7JR|UxRTJ3LkC5Nlgh|ryP NHT0[ZhUSU6JRWK=
NCI-H1623 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVLJR|UxRTJ5LkGzNFMh|ryP MX7TRW5ITVJ?
MOLT-13 NF\YSmFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoXvTWM2OD1{Nz6zOVE3KM7:TR?= M2PwUXNCVkeHUh?=
COLO-741 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXPJR|UxRTNzLkOzN|Mh|ryP MV;TRW5ITVJ?
NB6 NWnZUGc1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX72foY6UUN3ME2zNk4zQDd4IN88US=> M2LaNnNCVkeHUh?=
MOLT-16 NHzUTXNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkLXTWM2OD1|Mz6wNFU2KM7:TR?= Mn\QV2FPT0WU
IST-MES1 M3vXeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{fMXmlEPTB;M{SuNFU1OSEQvF2= Moe1V2FPT0WU
A4-Fuk MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVfJR|UxRTN3LkC2OkDPxE1? NYewb|VYW0GQR1XS
CAL-85-1 NGK4VGdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mof4TWM2OD1|NT6yPFE4KM7:TR?= NV\FRohYW0GQR1XS
CCRF-CEM M{DL[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXfCWlhYUUN3ME2zO{4yPTN4IN88US=> M2nWZ3NCVkeHUh?=
HAL-01 NULiNlVCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH3BfZhKSzVyPUO4MlQ5QDlizszN M17vZnNCVkeHUh?=
HEL NEm1WWhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYTJR|UxRTR|LkO0NFkh|ryP MoO3V2FPT0WU
EW-1 MoTWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MU\JR|UxRTR|LkS3Olgh|ryP NGW5VXJUSU6JRWK=
MDA-MB-231 M2HZWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn\NTWM2OD12NT6xNVk6KM7:TR?= MX;TRW5ITVJ?
ABC-1 NILmXpJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWHJR|UxRTR4Lki1N|gh|ryP NX\ieohuW0GQR1XS
NCI-H446 MnP5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkfuTWM2OD12OD61NFU5KM7:TR?= MX3TRW5ITVJ?
MHH-PREB-1 NXXD[ZpKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYPQ[5ZHUUN3ME20PU43ODB5IN88US=> MmfGV2FPT0WU
DOHH-2 NI\UTZhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{\2bmlEPTB;NEmuOlY2PiEQvF2= NXzT[HM2W0GQR1XS
GCT NXjte|BXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXnJR|UxRTR7Lk[5O|Yh|ryP NHrj[VVUSU6JRWK=

... Click to View More Cell Line Experimental Data

In vivo 17-AAG displays significantly higher binding affinity for Hsp90 from 3T3-src, B16 or CT26 xenografts in nude mice with IC50 values of 8-35 nM as compared with that from the normal tissues with IC50 values of 200-600 nM. [1] Administration of 17-AAG (~50 mg/kg) causes significant decline in AR, HER2, HER3, and Akt expression in a dose-dependent manner with >50% decline at dose of 50 mg/kg, resulting in the dose-dependent inhibition of androgen-dependent (CWR22) and -independent (CWR22R and CWRSA6) prostate cancer xenografts growth by 67%, 80% and 68% at dose of 50 mg/kg, respectively. [2]

Protocol

Kinase Assay:[1]
+ Expand

Hsp90 binding assays:

Purified native Hsp90 protein or cell lysates from HER-2-overexpressing cancer cells (BT474, N87, SKOV3 and SKBR3) or BT474 breast carcinoma cells in lysis buffer (20 mM HEPES, pH 7.3, 1 mM EDTA, 5 mM MgCl2, 100 mM KCl) are incubated with various concentrations of 17-AAG for 30 minutes at 4 °C, and then incubated with biotin-GM linked to BioMag streptavidin magnetic beads for 1 hour at 4 °C. Tubes are placed on a magnetic rack, and the unbound supernatant removed. The magnetic beads are washed three times in lysis buffer and heated for 5 minutes at 95 °C in SDS–PAGE sample buffer. Samples are analysed on SDS protein gels, and western blots done using indicated antibodies. Bands in the western blots are quantified using the Bio-rad Fluor-S MultiImager, and the percentage inhibition of binding of Hsp90 to the biotin-GM is calculated. The IC50 reported is the concentration of 17-AAG needed to cause half-maximal inhibition of binding.
Cell Research:[1]
+ Expand
  • Cell lines: BT474, SKBR3, N87, SKOV3, MCF7, MDA468, Hs578T, Hs578Bst, A549, HT29, U87, SKMG3, HT1080, RPTEC, NDF, HMVEC, HMEC, HUVEC, and PBMC cells
  • Concentrations: Dissolved in DMSO, final concentrations ~10 μM
  • Incubation Time: 5 days
  • Method: Cells are seeded in 96-well plates at 2,000 cells per well in a final culture volume of 100 μL for 24 hours before the addition of increasing concentrations of 17-AAG that is incubated for 5 days. Viable cell number is determined using the Celltiter 96 AQueous Nonradioactive Cell Proliferation Assay. The value of the background absorbance at 490 nm (A490) of wells not containing cells is subtracted. Percentage of viable cells = (A490 of 17-AAG treated sample/A490 untreated cells) × 100. The IC50 is defined as the concentration that gave rise to 50% viable cell number.
    (Only for Reference)
Animal Research:[2]
+ Expand
  • Animal Models: Male nu/nu athymic mice inoculated s.c. with androgen-dependent CWR22 xenograft, and female nu/nu athymic mice inoculated s.c. with androgen-independent xenografts CWR22R and CWRSA6
  • Formulation: Dissolved in DMSO, and diluted in egg phospholipids (EPL) vehicle
  • Dosages: ~50 mg/kg
  • Administration: Injection i.p.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 100 mg/mL (170.73 mM)
Ethanol 5 mg/mL (8.53 mM)
Water Insoluble
In vivo Add solvents to the product individually and in order:
5%DMSO+corn oil
For best results, use promptly after mixing.
10mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 585.69
Formula

C31H43N3O8

CAS No. 75747-14-7
Storage powder
Synonyms CP127374,NSC-330507, KOS 953

Bio Calculators

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT00577889 Completed Adenocarcinoma of the Pancreas|Recurrent Pancreatic Cancer|Stage IV Pancreatic Cancer National Cancer Institute (NCI) March 2008 Phase 2
NCT00546780 Completed Multiple Myeloma Bristol-Myers Squibb February 2008 Phase 3
NCT00093496 Completed Primary Peritoneal Cavity Cancer|Recurrent Ovarian Epithelial Cancer|Stage III Ovarian Epithelial Cancer|Stage IV Ovarian Epithelial Cancer National Cancer Institute (NCI) October 2007 Phase 2
NCT00514371 Completed Multiple Myeloma Bristol-Myers Squibb August 2007 Phase 2|Phase 3
NCT00779428 Completed Advanced Malignancies Bristol-Myers Squibb July 2006 Phase 2
NCT00354185 Terminated Adult Nasal Type Extranodal NK/T-cell Lymphoma|Anaplastic Large Cell Lymphoma|Angioimmunoblastic T-cell Lymphoma|Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue|Intraocular Lymphoma|Nodal Marginal Zone B-cell Lymphoma|Post-transplant Lymphoproliferative Disorder|Recurrent Adult Burkitt Lymphoma|Recurrent Adult Diffuse Large Cell Lymphoma|Recurrent Adult Diffuse Mixed Cell Lymphoma|Recurrent Adult Diffuse Small Cleaved Cell Lymphoma|Recurrent Adult Grade III Lymphomatoid Granulomatosis|Recurrent Adult Hodgkin Lymphoma|Recurrent Adult Immunoblastic Large Cell Lymphoma|Recurrent Adult Lymphoblastic Lymphoma|Recurrent Adult T-cell Leukemia/Lymphoma|Recurrent Cutaneous T-cell Non-Hodgkin Lymphoma|Recurrent Grade 1 Follicular Lymphoma|Recurrent Grade 2 Follicular Lymphoma|Recurrent Grade 3 Follicular Lymphoma|Recurrent Mantle Cell Lymphoma|Recurrent Marginal Zone Lymphoma|Recurrent Mycosis Fungoides/Sezary Syndrome|Recurrent Small Lymphocytic Lymphoma|Small Intestine Lymphoma|Splenic Marginal Zone Lymphoma|Stage III Adult Burkitt Lymphoma|Stage III Adult Diffuse Large Cell Lymphoma|Stage III Adult Diffuse Mixed Cell Lymphoma|Stage III Adult Diffuse Small Cleaved Cell Lymphoma|Stage III Adult Hodgkin Lymphoma|Stage III Adult Immunoblastic Large Cell Lymphoma|Stage III Adult Lymphoblastic Lymphoma|Stage III Adult T-cell Leukemia/Lymphoma|Stage III Cutaneous T-cell Non-Hodgkin Lymphoma|Stage III Grade 1 Follicular Lymphoma|Stage III Grade 2 Follicular Lymphoma|Stage III Grade 3 Follicular Lymphoma|Stage III Mantle Cell Lymphoma|Stage III Marginal Zone Lymphoma|Stage III Mycosis Fungoides/Sezary Syndrome|Stage III Small Lymphocytic Lymphoma|Stage IV Adult Burkitt Lymphoma|Stage IV Adult Diffuse Large Cell Lymphoma|Stage IV Adult Diffuse Mixed Cell Lymphoma|Stage IV Adult Diffuse Small Cleaved Cell Lymphoma|Stage IV Adult Hodgkin Lymphoma|Stage IV Adult Immunoblastic Large Cell Lymphoma|Stage IV Adult Lymphoblastic Lymphoma|Stage IV Adult T-cell Leukemia/Lymphoma|Stage IV Cutaneous T-cell Non-Hodgkin Lymphoma|Stage IV Grade 1 Follicular Lymphoma|Stage IV Grade 2 Follicular Lymphoma|Stage IV Grade 3 Follicular Lymphoma|Stage IV Mantle Cell Lymphoma|Stage IV Marginal Zone Lymphoma|Stage IV Mycosis Fungoides/Sezary Syndrome|Stage IV Small Lymphocytic Lymphoma|Unspecified Adult Solid Tumor, Protocol Specific|Waldenström Macroglobulinemia National Cancer Institute (NCI) May 2006 Phase 1

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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Frequently Asked Questions

  • Question 1:

    What kind of subtypes does this compound inhibit? HSP90α or HSP90β ?

  • Answer:

    17-AAG can inhibit both HSP90α and HSP90β, but it is unclear how much are they affected respectively. You should note that Hsp90 derived from tumor cells has a 100-fold higher binding affinity for 17-AAG than that from normal cells according to this paper. http://www.nature.com.ezp-prod1.hul.harvard.edu/nature/journal/v425/n6956/full/nature01913.html

HSP (e.g. HSP90) Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID