Tanespimycin (17-AAG)

Catalog No.S1141 Synonyms: CP127374,NSC-330507, KOS 953

Tanespimycin (17-AAG) Chemical Structure

Molecular Weight(MW): 585.69

Tanespimycin (17-AAG) is a potent HSP90 inhibitor with IC50 of 5 nM in a cell-free assay, having a 100-fold higher binding affinity for HSP90 derived from tumour cells than HSP90 from normal cells. Phase 2.

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In DMSO USD 195 In stock
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8 Customer Reviews

  • (A) Cell lines were seeded in 96-well plates and treated with 10 nM of 17-AAG for 72 h. Cell survival was analyzed using CellTiter-Glo. Both parental H3122 cells (red bar) and H3122 CR cells (blue bar) show sensitivity to 17-AAG. (B) Suppression of ALK signaling by 17-AAG in resistant H3122 CR cells. H3122 parental and resistant cells were exposed to increasing concentrations of 17-AAG for 6 h.

    PNAS, 2011, 108: 7535-40. Tanespimycin (17-AAG) purchased from Selleck.

    Four types of the colon cancer cells with indicated K-Ras phenotype were incubated with indicated concentration of 17-AAG for 24 h, which were then analyzed for protein expression by WB.

    Oncotarget 2014 5, 4269-82. Tanespimycin (17-AAG) purchased from Selleck.

  • Western blot analysis of immunoprecipitated Hsp90/BIP complexes in MOLT-4 (T-ALL) and RS4;11 (B-ALL) treated for 22 h with CX-4945 (5 μM) and bortezomib (2.5 nM) either alone or in combination. 500 μg of protein lysates were immunoprecipitated with anti-Hsp90 antibody. Relative Induction values (Rel.Ind.) were obtained by normalizing to Hsp90 bands density. 17-AAG: tanespimycin.

    Oncotarget, 2015, 51: S659-S660. Tanespimycin (17-AAG) purchased from Selleck.

    Co-IP analyses of direct interaction between HSP90 and HIF-1α in 17-AAG (5 μM)-treated HSCs using antibodies against HSP90, HIF-1α or IgG (n = 2).

    Br J Pharmacol, 2017, 174(5):409-423. Tanespimycin (17-AAG) purchased from Selleck.

  • UPR modulators destabilize mSmoM2. NIH 3T3 cells expressing mSmoM2 protein were treated with HSP90 inhibitors 17-AAG (50 uM and 100 uM) and SNX-2112 (25 uM and 50 uM) and the proteasome inhibitor bortezomib (25 uM and 50 uM) for 4 h prior to lysis. DMSO was the vehicle control. Western blotting of whole-cell lysates revealed mSmoM2 protein to be destabilized in response to HSP-90 inhibitors but not in response to bortezomib. Tubulin was the loading control. CHOP results indicate ER stress.

    Mol Cell Biol 2013 33(12), 2375-87. Tanespimycin (17-AAG) purchased from Selleck.

    Treatment with an Hsp90 inhibitor results in a dose-dependent decrease in complex IV activity. A, because Hsp90 levels were reduced by 80%, in PINK1 null dopaminergic neuronal cells, the effects of specific inhibition of Hsp90 using 17-AAG were analyzed in wild-type neuronal cells. Both complex IV activity and Hsp60 levels were decreased significantly in 17-AAG-treated cells in a dose-dependent manner. B, in contrast, 17-AAG treatment did not affect expression of Hsp90 and LRPPRC.

    J Biol Chem 2012 287, 44109-20. Tanespimycin (17-AAG) purchased from Selleck.

  • SKBR3 cells were treated with FW-04-806 at 10, 20, 40 uM for 24 h; 17AAG was used as a positive control at 1 and 2 uM. Hsp70, Hsp90, and Cdc37 protein level were analyzed with western blotting using relevant antibodies.

    Mol Cancer 2014 13, 150. Tanespimycin (17-AAG) purchased from Selleck.

    Hsp90 is up-regulated during aging. Whole-cell extracts were prepared from young (PD 20) and old (PD 40) HFSN1 cells. c HFSN1 cells (PD 40) were treated with different concentration of the Hsp90 inhibitor (17-AAG) and then re-incubated for 24 h. Whole-cell extracts were prepared and analyzed by western blot using the indicated antibodies.

    Age 2013 35, 549-62. Tanespimycin (17-AAG) purchased from Selleck.

Purity & Quality Control

Choose Selective HSP (e.g. HSP90) Inhibitors

Biological Activity

Description Tanespimycin (17-AAG) is a potent HSP90 inhibitor with IC50 of 5 nM in a cell-free assay, having a 100-fold higher binding affinity for HSP90 derived from tumour cells than HSP90 from normal cells. Phase 2.
Features Displays very low toxicity toward normal cells.
Targets
HSP90 [1]
(Cell-free assay)
5 nM
In vitro

17-AAG, an analog of geldanamycin, exhibits greater than 100 times higher binding affinity for Hsp90 derived from HER-2-overexpressing cancer cells (BT474, N87, SKOV3 and SKBR3) or BT474 breast carcinoma cells with IC50 values of 5-6 nM. [1] 17-AAG causes the degradation of HER2, HER3, Akt, and both mutant and wild-type androgen receptor (AR), leading to the RB-dependent G1 growth arrest of prostate cancer cells such as LNCaP, LAPC-4, DU-145, and PC-3 with IC50 values of 25-45 nM. [2] In addition to inducing apoptosis of Ba/F3 cells transformed with wild-type BCR-ABL with an IC50 of 5.2 μM, 17-AAG has the ability to induce apoptosis of cells transformed with imatinib mesylate-resistant T315I and E255K BCR-ABL mutants with IC50 values of 2.3 μM and 1.0 μM, respectively, by inducing the degradation of both wild-type BCR-ABL protein and mutants. [3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
A549 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVzXV|RHUUN3ME2wMlAxODNyMzFOwG0> MUnTRW5ITVJ?
IST-MEL1 M3z4PWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFqycolKSzVyPUCuNFAxPDB5IN88US=> NG\NPYVUSU6JRWK=
NCI-SNU-1 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFLWeHpKSzVyPUCuNFAzODdizszN MX7TRW5ITVJ?
FADU NEX6OJNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1TSd2lEPTB;MD6wNFIxQSEQvF2= MUnTRW5ITVJ?
C32 MmHuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MorVTWM2OD1yLkCwN|A1KM7:TR?= NYXMTJdsW0GQR1XS
D-566MG NUPoXlN6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVjnWnV4UUN3ME2wMlAxOzlizszN MYfTRW5ITVJ?
LXF-289 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGnPcW9KSzVyPUCuNFA1OTlizszN NIjZdIpUSU6JRWK=
HGC-27 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnLyTWM2OD1yLkCwOVEh|ryP MoHmV2FPT0WU
RPMI-7951 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH74e3JKSzVyPUCuNFA4OTdizszN MY\TRW5ITVJ?
HSC-3 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3rTOGlEPTB;MD6wNFkzQSEQvF2= MlrnV2FPT0WU
MIA-PaCa-2 NVTLbHk{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2\NfGlEPTB;MD6wNVAxQSEQvF2= Mn;mV2FPT0WU
KS-1 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1nJN2lEPTB;MD6wNVM2PSEQvF2= M4S3bHNCVkeHUh?=
CAL-51 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3PlRWlEPTB;MD6wNVQxPSEQvF2= NVu2[49lW0GQR1XS
MDA-MB-361 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2q4[2lEPTB;MD6wNVQ6PSEQvF2= MVvTRW5ITVJ?
TI-73 MofDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXnob|NPUUN3ME2wMlAyPzl4IN88US=> M2K0NXNCVkeHUh?=
AGS NXTCRm5JT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH\KemRKSzVyPUCuNFE6OzhizszN M4PSWXNCVkeHUh?=
NCI-H460 NF\rXmZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXvJR|UxRTBwMEG5O|Qh|ryP NH\H[pFUSU6JRWK=
A204 MnPLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXLJR|UxRTBwMEKyOFkh|ryP M{\GO3NCVkeHUh?=
CHL-1 NILFfm5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGDlb2FKSzVyPUCuNFIzPTFizszN NFLvfGtUSU6JRWK=
DU-4475 M4DiUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml7GTWM2OD1yLkCyNlYyKM7:TR?= NWf5b|FTW0GQR1XS
CGTH-W-1 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVXlc4VPUUN3ME2wMlAzOzR7IN88US=> MluxV2FPT0WU
HCC2218 NIP1ZWJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mo\LTWM2OD1yLkCyOFk1KM7:TR?= Mnq0V2FPT0WU
A2780 M1W0b2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWrJR|UxRTBwMEK1N|Eh|ryP MnjQV2FPT0WU
NCI-H720 Mk\5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NELxNWhKSzVyPUCuNFI2PDZizszN M36xcHNCVkeHUh?=
NCI-N87 NGXyeFZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWW2Ulk6UUN3ME2wMlAzPTl|IN88US=> NWLQcJFvW0GQR1XS
CHP-212 Ml;4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2X2VWlEPTB;MD6wNlYzQCEQvF2= NF;KNolUSU6JRWK=
NCI-H23 MlTwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWjhUJpsUUN3ME2wMlAzPjZ3IN88US=> NXzxcWJ{W0GQR1XS
D-263MG NH3TcXNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXLJR|UxRTBwMEK3PFYh|ryP NU\D[JdmW0GQR1XS
ME-180 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVzSOJF4UUN3ME2wMlAzQDlzIN88US=> NH\PV5pUSU6JRWK=
SW982 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmD1TWM2OD1yLkCyPVk6KM7:TR?= NULad3N4W0GQR1XS
OE19 M1zYOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4DyUWlEPTB;MD6wN|A4PyEQvF2= M4X6WnNCVkeHUh?=
SK-LU-1 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnLMTWM2OD1yLkCzNFgzKM7:TR?= NYTEeIFEW0GQR1XS
H4 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWrJR|UxRTBwMEOwPUDPxE1? MVPTRW5ITVJ?
HT-144 M{KyTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWfEcIcyUUN3ME2wMlA{ODl|IN88US=> Ml\nV2FPT0WU
SK-UT-1 NIG3XpFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{DMUmlEPTB;MD6wN|E4QCEQvF2= NFLkTJRUSU6JRWK=
D-336MG MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIP2UJVKSzVyPUCuNFM{ODlizszN M3jqO3NCVkeHUh?=
MDA-MB-175-VII NX7V[HhFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIjkU4JKSzVyPUCuNFM{PTRizszN MmjZV2FPT0WU
GAMG M4TqN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3\CeWlEPTB;MD6wN|Q{PSEQvF2= NUPDSVA5W0GQR1XS
CP50-MEL-B Moq1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3PCTmlEPTB;MD6wN|Q2KM7:TR?= NWPOdFY2W0GQR1XS
OVCAR-5 M4HYdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXzJR|UxRTBwMEO0PEDPxE1? M2LhNXNCVkeHUh?=
SK-MES-1 M{[5NWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoPJTWM2OD1yLkCzOlA3KM7:TR?= NYrBUIpzW0GQR1XS
VM-CUB-1 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4PhfmlEPTB;MD6wN|Y2PyEQvF2= NY\5OmtZW0GQR1XS
WM-115 M1nlW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NY\DUoxMUUN3ME2wMlA{PzZ{IN88US=> NF\wemdUSU6JRWK=
DSH1 NX;QXGJqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVrJR|UxRTBwMEO4NFch|ryP NYDzXWhmW0GQR1XS
Becker NWKwNVRjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3fOUmlEPTB;MD6wN|g5PSEQvF2= NV;rd4hHW0GQR1XS
SW962 M{LMO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUPlN4NHUUN3ME2wMlA{QTR3IN88US=> MmDZV2FPT0WU
TYK-nu NEnwXIxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn;1TWM2OD1yLkCzPVg2KM7:TR?= Mk\wV2FPT0WU
HO-1-N-1 M17ybWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXHJR|UxRTBwMESwNlEh|ryP NWnkdoxjW0GQR1XS
T98G MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3OwfmlEPTB;MD6wOFExOyEQvF2= NXnyZldyW0GQR1XS
ACN NUC4TJVPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mo\BTWM2OD1yLkC0NVYzKM7:TR?= NGjHRW1USU6JRWK=
SW780 M1ezbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MULJR|UxRTBwMESyNFMh|ryP M1j0NXNCVkeHUh?=
Detroit562 M{L3W2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml3rTWM2OD1yLkC0NlM6KM7:TR?= NET4PXlUSU6JRWK=
BB49-HNC NWDUR5ExT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3u1TGlEPTB;MD6wOFI1OyEQvF2= NG\kb3dUSU6JRWK=
HN MoXLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml3DTWM2OD1yLkC0NlczKM7:TR?= MnfyV2FPT0WU
H9 M4TpSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYHkXYF{UUN3ME2wMlA1OzdzIN88US=> Ml3CV2FPT0WU
VA-ES-BJ NHL5WXVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnT4TWM2OD1yLkC0OFQ4KM7:TR?= NYf5RlhUW0GQR1XS
MEL-JUSO MlT0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2nLR2lEPTB;MD6wOFQ4PSEQvF2= NWPSU45vW0GQR1XS
BT-474 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2nFeWlEPTB;MD6wOFUh|ryP NFzPTXNUSU6JRWK=
CaR-1 NI\6b3dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXrocXJyUUN3ME2wMlA1PTR7IN88US=> MXfTRW5ITVJ?
PSN1 NELzPXZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mo\wTWM2OD1yLkC0OlA{KM7:TR?= NV3wTotNW0GQR1XS
KYSE-510 NYfycGpTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWLJR|UxRTBwMES2OFkh|ryP MoDMV2FPT0WU
KP-4 Ml7tS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mly4TWM2OD1yLkC0O|U{KM7:TR?= MWHTRW5ITVJ?
KYSE-410 MnrRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV\aVpViUUN3ME2wMlA1Pzd{IN88US=> MWPTRW5ITVJ?
G-402 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3XVUWlEPTB;MD6wOFc5QSEQvF2= M1z1SXNCVkeHUh?=
DOK NFS3bm1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHXsdmRKSzVyPUCuNFQ6ODJizszN NGntR45USU6JRWK=
COR-L88 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1j5WWlEPTB;MD6wOFkyOiEQvF2= MX;TRW5ITVJ?
SKG-IIIa NHyyPHVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3r6b2lEPTB;MD6wOFk5PiEQvF2= NUjONFBLW0GQR1XS
AN3-CA MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlrJTWM2OD1yLkC1JO69VQ>? NUHUbmRIW0GQR1XS
SW48 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoHpTWM2OD1yLkC1NFM6KM7:TR?= MX3TRW5ITVJ?
YKG-1 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmXNTWM2OD1yLkC1NFcyKM7:TR?= NYjoUld3W0GQR1XS
KYSE-150 Mn3SS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWXJR|UxRTBwMEWyN|Uh|ryP MVnTRW5ITVJ?
HuO-3N1 NEDEdYVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M33EcmlEPTB;MD6wOVI{PyEQvF2= MU\TRW5ITVJ?
LB1047-RCC NUDmc3F5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUfXVFg3UUN3ME2wMlA2Ojl4IN88US=> M{X4VnNCVkeHUh?=
NCI-H2030 NYn2V|l4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXixTWxtUUN3ME2wMlA2PDF2IN88US=> MXvTRW5ITVJ?
YH-13 NYT6RZJKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWXJR|UxRTBwMEW3NlIh|ryP NXn5d|FoW0GQR1XS
5637 NVe0T5ZrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX\JR|UxRTBwMEW3OEDPxE1? M2jkdHNCVkeHUh?=
LOXIMVI NW\IPJBVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4fzV2lEPTB;MD6wOVg4OiEQvF2= NUjjfogyW0GQR1XS
GT3TKB NX;IV4V[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUDJR|UxRTBwMEW5OFIh|ryP MXrTRW5ITVJ?
TCCSUP MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXTJR|UxRTBwMEW5OlQh|ryP M2GwNXNCVkeHUh?=
EPLC-272H NWXNNYNxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1fQ[2lEPTB;MD6wOlIxPSEQvF2= NXXxepZvW0GQR1XS
LU-99A M160Wmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX;IOWUxUUN3ME2wMlA3OjN5IN88US=> M1nvVXNCVkeHUh?=
NCI-H1755 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVOwSHl5UUN3ME2wMlA3OzRzIN88US=> NXnrTmM{W0GQR1XS
KM12 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MULJR|UxRTBwME[zOFgh|ryP MXHTRW5ITVJ?
SF295 M2rIcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NITqR3NKSzVyPUCuNFY1PTJizszN Mm\iV2FPT0WU
MZ2-MEL NHvrRZlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWnJR|UxRTBwME[1OVMh|ryP NH3xbGVUSU6JRWK=
HEC-1 Mn7ZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnOzTWM2OD1yLkC2OVg5KM7:TR?= M2fRe3NCVkeHUh?=
SW684 NFPqW3pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnH3TWM2OD1yLkC2OVkyKM7:TR?= NE\rSoxUSU6JRWK=
SF539 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXnaZ2F7UUN3ME2wMlA3PjhzIN88US=> MlrnV2FPT0WU
GMS-10 MmHSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYrJR|UxRTBwME[2PVkh|ryP NH7CXnNUSU6JRWK=
MV-4-11 NYDXcFJIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF3qTpJKSzVyPUCuNFY5ODNizszN NYOzSlc1W0GQR1XS
HT-29 Mo\GS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYrJR|UxRTBwME[5NVkh|ryP NFnPXm5USU6JRWK=
23132-87 NUPWPHZTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYnPfpRuUUN3ME2wMlA3QTVizszN NIPQelJUSU6JRWK=
SW620 Ml3rS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn[yTWM2OD1yLkC3NFI3KM7:TR?= M1f6[HNCVkeHUh?=
HCC1806 M1nJSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1\p[WlEPTB;MD6wO|E{OSEQvF2= NGnTdGNUSU6JRWK=
Hs-578-T M2qw[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIHvblFKSzVyPUCuNFczODhizszN M3u1b3NCVkeHUh?=
A2058 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWKxcHlNUUN3ME2wMlA4OjJ6IN88US=> M{PpdHNCVkeHUh?=
MEL-HO MlXuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1;VO2lEPTB;MD6wO|I2PSEQvF2= M{HWNXNCVkeHUh?=
HCC2998 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVfJR|UxRTBwMEezOFch|ryP NVHheYU2W0GQR1XS
HuO9 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWfJR|UxRTBwMEe1PFkh|ryP MonWV2FPT0WU
CAL-39 NH\JZoJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkD5TWM2OD1yLkC3O|Y3KM7:TR?= M3HvfXNCVkeHUh?=
M14 NF3Gb4lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3TNVmlEPTB;MD6wO|kyOyEQvF2= NEHReFRUSU6JRWK=
BFTC-909 Mm\TS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVvJR|UxRTBwMEe5Olkh|ryP NUn4Uo9ZW0GQR1XS
TE-11 NIXEfFhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXXJR|UxRTBwMEe5PVYh|ryP NXfzOWpbW0GQR1XS
TGBC1TKB NVjRSI42T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1r2dmlEPTB;MD6wPFA1OyEQvF2= NGfHT|RUSU6JRWK=
L-363 M4GzcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYPJR|UxRTBwMEiyNFYh|ryP MoH2V2FPT0WU
A431 NIPOb5ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3K3O2lEPTB;MD6wPFIyKM7:TR?= MUTTRW5ITVJ?
MKN45 NYPmemdWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYjF[3dGUUN3ME2wMlA5OjF7IN88US=> MWPTRW5ITVJ?
HT-1080 NGf1eZZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYrreVhYUUN3ME2wMlA5PDN7IN88US=> NUe1d3hWW0GQR1XS
OVCAR-8 NGKyZ2ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGflfGlKSzVyPUCuNFg3OjJizszN NEXidHFUSU6JRWK=
LCLC-97TM1 M3XVXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWnhT|J{UUN3ME2wMlA5PzJ6IN88US=> NUnwbmR2W0GQR1XS
M059J NX\reY9ET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYPJR|UxRTBwMEmwNlch|ryP NYfUSnY1W0GQR1XS
SK-MEL-2 MkjLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV\JR|UxRTBwMEmwOkDPxE1? M3fDXHNCVkeHUh?=
TE-1 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUjkfXhSUUN3ME2wMlA6OjB2IN88US=> NF\D[FVUSU6JRWK=
KYSE-180 M2L2OWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mnq3TWM2OD1yLkC5NlYzKM7:TR?= MknTV2FPT0WU
D-247MG MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX7JR|UxRTBwMEm0OVUh|ryP Mme0V2FPT0WU
8-MG-BA MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnryTWM2OD1yLkC5OFczKM7:TR?= NYTxNGJJW0GQR1XS
NCI-H1792 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{Lvd2lEPTB;MD6wPVYyQCEQvF2= NHT4d3VUSU6JRWK=
MCF7 NHLN[mZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHX6VYNKSzVyPUCuNFk3PzdizszN MX3TRW5ITVJ?
NCI-H2122 Mon5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUfJR|UxRTBwMEm3OFUh|ryP MUXTRW5ITVJ?
EFO-27 NUG0b5kxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEj2[o1KSzVyPUCuNFk6QTdizszN Mk[yV2FPT0WU
LB2241-RCC MkizS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3fuZ2lEPTB;MD6xNFA2PCEQvF2= M3nBUXNCVkeHUh?=
SN12C MmLOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MU\JR|UxRTBwMUCxNFch|ryP NITj[4VUSU6JRWK=
A498 M2LxbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoPjTWM2OD1yLkGwNVgh|ryP MVvTRW5ITVJ?
PANC-03-27 NVPObVdnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1q5d2lEPTB;MD6xNFI5PiEQvF2= NVPiV5F7W0GQR1XS
NCI-H1581 NE\rZlRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEHmSIFKSzVyPUCuNVAzQSEQvF2= Ml3jV2FPT0WU
U-87-MG NH3ROGFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYDJR|UxRTBwMUCzNFch|ryP MUTTRW5ITVJ?
G-401 M{PLSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEDXZ5pKSzVyPUCuNVA{PTNizszN NWjWUo5ZW0GQR1XS
SiHa M{j5Omdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NU\xVndkUUN3ME2wMlExPDh4IN88US=> MXTTRW5ITVJ?
U251 NXnIbo1zT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mm\LTWM2OD1yLkGwOVI2KM7:TR?= MYLTRW5ITVJ?
MMAC-SF NHLYcIJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWLJR|UxRTBwMUC1N|Eh|ryP MmL1V2FPT0WU
BB65-RCC MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnW3TWM2OD1yLkGwOVU1KM7:TR?= MoT6V2FPT0WU
NKM-1 Ml6zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWfCfJQ1UUN3ME2wMlExPjZ4IN88US=> NVrySYxXW0GQR1XS
HD-MY-Z MlWxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2nNdWlEPTB;MD6xNFg4OyEQvF2= NHqzfWNUSU6JRWK=
TGBC11TKB MnK3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH[xc5FKSzVyPUCuNVA6ODNizszN M{HnW3NCVkeHUh?=
COLO-679 M1rP[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlfDTWM2OD1yLkGxNlEyKM7:TR?= NGTBNIxUSU6JRWK=
TE-8 NVThcmpwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUfmPWM4UUN3ME2wMlEyOjZ2IN88US=> MUDTRW5ITVJ?
SK-MEL-28 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3ToZmlEPTB;MD6xNVMzOSEQvF2= MVHTRW5ITVJ?
SH-4 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFPXcJJKSzVyPUCuNVE{PTZizszN MYTTRW5ITVJ?
KALS-1 NIPRcGNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2DpUWlEPTB;MD6xNVM6OyEQvF2= MXTTRW5ITVJ?
RKO NXj4U2VGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX\iZolpUUN3ME2wMlEyPzZ2IN88US=> NYLtXJNFW0GQR1XS
OMC-1 NXjZcphpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYS3N3g3UUN3ME2wMlEyPzl5IN88US=> NG\tfYtUSU6JRWK=
BT-549 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{HIXGlEPTB;MD6xNVc6QSEQvF2= M4TCZXNCVkeHUh?=
NCI-H28 M{PGOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWm3bGVUUUN3ME2wMlEyQDF5IN88US=> MUfTRW5ITVJ?
RXF393 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWnJR|UxRTBwMUG5PFIh|ryP MVnTRW5ITVJ?
COLO-829 NIHEbllIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX7JR|UxRTBwMUKwNFUh|ryP MnTQV2FPT0WU
HMV-II NFu0[IZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXrJR|UxRTBwMUKwNkDPxE1? MUjTRW5ITVJ?
SW1990 NHOzOY1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUXJR|UxRTBwMUKxOVch|ryP MX7TRW5ITVJ?
NCI-H1437 NWLufFZYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXrEZmp1UUN3ME2wMlEzOTV5IN88US=> NIT1XlRUSU6JRWK=
SNB75 Mmj4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYLJR|UxRTBwMUKxOlkh|ryP MonHV2FPT0WU
EW-3 NG\adVRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWXJR|UxRTBwMUK2OlEh|ryP NE\GS2tUSU6JRWK=
SAS MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWfJR|UxRTBwMUK2PUDPxE1? NHO3bFdUSU6JRWK=
NCI-H1666 MnHMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NILvdW1KSzVyPUCuNVI4PzRizszN M4r4bXNCVkeHUh?=
A375 M{XWOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3TSTGlEPTB;MD6xNlc4QCEQvF2= M33SOHNCVkeHUh?=
CAMA-1 NYG3Z45LT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3XJbGlEPTB;MD6xNlkzPCEQvF2= MlnJV2FPT0WU
HuP-T4 MmjiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHPq[nNKSzVyPUCuNVI6PDNizszN NWP0fXdZW0GQR1XS
NCI-H292 NF3mdnNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVrLU4hYUUN3ME2wMlE{OTFizszN MlvxV2FPT0WU
PC-14 MmXkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVrWZo5HUUN3ME2wMlE{OjFzIN88US=> NGfOeIpUSU6JRWK=
BPH-1 NI\nN3pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGLaSoJKSzVyPUCuNVM1OSEQvF2= MVLTRW5ITVJ?
GAK NVf4N5VCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3\udWlEPTB;MD6xN|U3PyEQvF2= M3P6c3NCVkeHUh?=
VMRC-RCZ NEPVbmdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1vsOGlEPTB;MD6xN|c3OiEQvF2= M1jwWXNCVkeHUh?=
SK-MEL-24 M3vKSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3LrS2lEPTB;MD6xN|g4KM7:TR?= MoPOV2FPT0WU
LB831-BLC NXi4U4VnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWPJR|UxRTBwMUO4PFMh|ryP NGLIRXZUSU6JRWK=
NCI-H2452 M4LabWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXvJR|UxRTBwMUO5OVYh|ryP MVLTRW5ITVJ?
RT-112 NHe0Zm5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV;JR|UxRTBwMUSwN|Uh|ryP NIXJSVFUSU6JRWK=
GP5d MkS4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{nOTWlEPTB;MD6xOFExPCEQvF2= NWPFcYlkW0GQR1XS
LC-2-ad MlXyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXXJR|UxRTBwMUSxNlEh|ryP NYXGNXpnW0GQR1XS
MPP-89 Mm\GS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NE\1RZZKSzVyPUCuNVQyOjVizszN MnfZV2FPT0WU
NUGC-3 M4HKSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXHJR|UxRTBwMUS0O|gh|ryP NVTBS4ZlW0GQR1XS
GI-1 Mn22S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXrafHFiUUN3ME2wMlE1PTV6IN88US=> NUntboE4W0GQR1XS
HCC1419 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1ezWWlEPTB;MD6xOFU4PiEQvF2= NFnmbVFUSU6JRWK=
SW1573 MoTUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIrLT2pKSzVyPUCuNVQ4PThizszN M3LMdnNCVkeHUh?=
NCI-H2347 MnXoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmrDTWM2OD1yLkG0PFM6KM7:TR?= NIjI[VJUSU6JRWK=
Mewo NF;U[3ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVjJR|UxRTBwMUS4PFkh|ryP MoTiV2FPT0WU
639-V MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUPJR|UxRTBwMUWwNVMh|ryP MXTTRW5ITVJ?
AsPC-1 MoTYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVLJR|UxRTBwMUWyNlUh|ryP MWnTRW5ITVJ?
NCI-H1648 Mn2wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml7UTWM2OD1yLkG1NlMzKM7:TR?= MVXTRW5ITVJ?
786-0 M2nXU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn7OTWM2OD1yLkG1N|gyKM7:TR?= MnS2V2FPT0WU
ETK-1 M3zKfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYG5NW1oUUN3ME2wMlE2QSEQvF2= MWPTRW5ITVJ?
BxPC-3 NEDzd29Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mm\qTWM2OD1yLkG1PVY3KM7:TR?= MoS1V2FPT0WU
CAL-62 M{PZfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF;CWGRKSzVyPUCuNVYyPjlizszN M{PITXNCVkeHUh?=
HCC1937 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnzBTWM2OD1yLkG2Nlc2KM7:TR?= M3;NfnNCVkeHUh?=
NCI-H1299 M37ZT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{j5bmlEPTB;MD6xOlI5PSEQvF2= NXSxVY9JW0GQR1XS
SW1088 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mnu4TWM2OD1yLkG2OFE{KM7:TR?= MlX3V2FPT0WU
FTC-133 M2fGTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmnTTWM2OD1yLkG2OVQh|ryP M1;vfXNCVkeHUh?=
OC-314 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEi1fIZKSzVyPUCuNVY3QSEQvF2= MlvNV2FPT0WU
SCC-9 NWW4PGtZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MY\JR|UxRTBwMU[3NVYh|ryP M3\BPHNCVkeHUh?=
HT-1376 NFTOfotIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVHJR|UxRTBwMU[5N|Yh|ryP M17IRXNCVkeHUh?=
U-2-OS MmXUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWHzdZZ7UUN3ME2wMlE4OTd|IN88US=> Mn3iV2FPT0WU
COLO-824 M2XnNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV3RTXdqUUN3ME2wMlE4Ojl2IN88US=> Mnn5V2FPT0WU
BB30-HNC NFvyVJlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnTXTWM2OD1yLkG3N|Mh|ryP M3LMNHNCVkeHUh?=
NCI-H2087 NW\ndXc3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlPvTWM2OD1yLkG3N|Y5KM7:TR?= M{jOcnNCVkeHUh?=
NCI-H2170 NXOwXppuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVXJR|UxRTBwMUe1N|Yh|ryP MoD6V2FPT0WU
SK-OV-3 MkDZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mnf5TWM2OD1yLkG3OVcyKM7:TR?= NHXheJpUSU6JRWK=
MZ7-mel MmjIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV6yS2dmUUN3ME2wMlE4PjR7IN88US=> NIrXOGFUSU6JRWK=
NCI-H650 MmC2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH61SGJKSzVyPUCuNVc3QDJizszN NEG5N3BUSU6JRWK=
KOSC-2 M2fEOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml2wTWM2OD1yLkG3O|M1KM7:TR?= NWHJSWl{W0GQR1XS
SCC-4 M1rJd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUX3SVQ{UUN3ME2wMlE4Pzd5IN88US=> NGPhb5RUSU6JRWK=
MDA-MB-157 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXjpcJhbUUN3ME2wMlE5ODh{IN88US=> MlS4V2FPT0WU
KYSE-520 M{TLT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFP2XZlKSzVyPUCuNVgzKM7:TR?= NVe1NWJmW0GQR1XS
LK-2 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXvJR|UxRTBwMUizNFMh|ryP NYnrSYtuW0GQR1XS
KNS-81-FD NXy0VoZVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4r3cWlEPTB;MD6xPFM6PCEQvF2= MlfQV2FPT0WU
IGROV-1 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NU\Ofog5UUN3ME2wMlE5PDR|IN88US=> NGS3Z5FUSU6JRWK=
DEL NGf6WYVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVHzWWs3UUN3ME2wMlE5PDVizszN M2WzdXNCVkeHUh?=
NCI-H1395 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml3pTWM2OD1yLkG4OlgzKM7:TR?= M2jJVnNCVkeHUh?=
JEG-3 MlSwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWrJR|UxRTBwMUi3NFUh|ryP M1jpeXNCVkeHUh?=
BCPAP NX7udWJsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFHVXXdKSzVyPUCuNVg5PzJizszN NIXa[4pUSU6JRWK=
CAL-27 NIrIZoNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkjMTWM2OD1yLkG5NFIzKM7:TR?= M1ftPHNCVkeHUh?=
RD MoTnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUHJR|UxRTBwMUmxNVMh|ryP NUnhW5NLW0GQR1XS
RVH-421 M1;vVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkHJTWM2OD1yLkG5NVE3KM7:TR?= NV7kcYprW0GQR1XS
Capan-2 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mo\zTWM2OD1yLkG5NlU3KM7:TR?= MVvTRW5ITVJ?
COLO-680N MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoLFTWM2OD1yLkG5N|Y1KM7:TR?= MX3TRW5ITVJ?
NCI-H1650 NXThdlhkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIDvO5lKSzVyPUCuNlAxPTdizszN NGTHSo9USU6JRWK=
SBC-5 NVPqOYtST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWjJR|UxRTBwMkCxNVgh|ryP MnTnV2FPT0WU
U031 NWLK[ZVpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHjiZohKSzVyPUCuNlA2PDdizszN MVzTRW5ITVJ?
S-117 NYf0N45wT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{XPSmlEPTB;MD6yNFU3PCEQvF2= Ml3PV2FPT0WU
DoTc2-4510 MomwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWPkUGZqUUN3ME2wMlIxPzZ7IN88US=> MUDTRW5ITVJ?
AM-38 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXnDVmRmUUN3ME2wMlIxQDR6IN88US=> MVrTRW5ITVJ?
A172 NVX0[W53T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{HHTWlEPTB;MD6yNVAzOiEQvF2= MnS4V2FPT0WU
HPAF-II MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXLJVpNxUUN3ME2wMlIyOjZ2IN88US=> MYHTRW5ITVJ?
769-P NHHybYhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXHJR|UxRTBwMkGyPEDPxE1? M164VXNCVkeHUh?=
MFE-280 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHLFSnZKSzVyPUCuNlEzQThizszN M3jFRXNCVkeHUh?=
TE-9 MkLYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{nlbmlEPTB;MD6yNVc5PiEQvF2= Ml:2V2FPT0WU
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EoL-1-cell M2LLU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NETZS2pKSzVyPUCuNlIzODNizszN MlPYV2FPT0WU
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BEN NH3OWFlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M13kdmlEPTB;MUGuPFUyKM7:TR?= NVu2UVA2W0GQR1XS
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HLE MlXUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWfJR|UxRTF{LkiyNVUh|ryP M4DQOnNCVkeHUh?=
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COLO-320-HSR MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX;JR|UxRTF|LkezPFEh|ryP MnnWV2FPT0WU
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MEG-01 NEjNS4ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3SzSGlEPTB;MUSuN|cxQCEQvF2= NXn5O29vW0GQR1XS
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NCI-H1304 Mk\PS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4D2fmlEPTB;MUWuNFQzPSEQvF2= MX7TRW5ITVJ?
Ramos-2G6-4C10 NV\1VWJQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3P1UWlEPTB;MUWuNFU5OSEQvF2= MkP4V2FPT0WU
NCI-H2342 NXWyTFdiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVn6WI5WUUN3ME2xOU4zODR2IN88US=> NEDJUllUSU6JRWK=
LAN-6 Mkj5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVLJR|UxRTF3LkS0NVQh|ryP NWnCcWJjW0GQR1XS
JVM-2 NXvDOpJQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUTJR|UxRTF3LkW3OFgh|ryP NGPYWoVUSU6JRWK=
P30-OHK MkLlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{LYVGlEPTB;MU[uNFYyPCEQvF2= MoHqV2FPT0WU
C-33-A MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV3JR|UxRTF4Lk[yNVQh|ryP NUnTRW9RW0GQR1XS
RPMI-8866 Mn7OS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEiwNXlKSzVyPUG2Mlg1QTZizszN MoHVV2FPT0WU
NCI-H630 NU\LS4hMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIHHXW5KSzVyPUG2Mlg2OzdizszN NGG5enNUSU6JRWK=
KYSE-140 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWrJR|UxRTF5LkKwNlgh|ryP MVXTRW5ITVJ?
T84 MoLYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH3lOIFKSzVyPUG4Mlg3QTVizszN NG\PNlRUSU6JRWK=
KU-19-19 MmDTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWnORYFEUUN3ME2xPE46PjB6IN88US=> NFPEU|BUSU6JRWK=
BALL-1 NUj1OmNDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV3H[VBkUUN3ME2xPU4{Ozl7IN88US=> MnnCV2FPT0WU
Calu-6 MlrTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml\ZTWM2OD1zOT60PVIh|ryP MnnKV2FPT0WU
EGI-1 M{L3bGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUnMW4d{UUN3ME2xPU42QThizszN MljWV2FPT0WU
MFH-ino MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkLTTWM2OD1zOT63OFU1KM7:TR?= NIC3SJVUSU6JRWK=
GB-1 M4X6[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MofaTWM2OD1{MD6zOVM2KM7:TR?= M2n5[3NCVkeHUh?=
NCI-H1693 NGfrZVJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFvJXXVKSzVyPUKwMlY2ODVizszN MYXTRW5ITVJ?
SW1116 M3nLV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUjYOok2UUN3ME2yNE46OzZ{IN88US=> MVrTRW5ITVJ?
H-EMC-SS NG[xTlhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXu3OmpkUUN3ME2yNk4xPDVizszN M1rTWnNCVkeHUh?=
D-502MG NUCwO2lYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXnJR|UxRTJ{LkiyOlEh|ryP MnfUV2FPT0WU
IA-LM MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV;JR|UxRTJ|LkK0PVMh|ryP MV;TRW5ITVJ?
SW1463 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlHxTWM2OD1{Mz63PUDPxE1? NVH6SWlqW0GQR1XS
JAR NF3MNG9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXPJR|UxRTJ2LkOyPVMh|ryP M3fLPHNCVkeHUh?=
HT NVPrbJhST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYnJR|UxRTJ2LkS3OVMh|ryP MVrTRW5ITVJ?
LCLC-103H M3;NXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEf4VZFKSzVyPUK0Mlg1PDlizszN MX3TRW5ITVJ?
SNU-449 NFjMbVNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnrCTWM2OD1{ND64O|QyKM7:TR?= MlvsV2FPT0WU
KE-37 M2j6VWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV7JR|UxRTJ3LkC5Nlgh|ryP MlHiV2FPT0WU
NCI-H1623 NGnVb3NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFTIOJNKSzVyPUK3MlE{ODNizszN MmrHV2FPT0WU
MOLT-13 M3vWdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVq3[nRYUUN3ME2yO{4{PTF4IN88US=> NVX0TIpvW0GQR1XS
COLO-741 MkXaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NITDcJhKSzVyPUOxMlM{OzNizszN NILDOIxUSU6JRWK=
NB6 M4XEXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX7JR|UxRTN{LkK4O|Yh|ryP NGfPOpdUSU6JRWK=
MOLT-16 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVXJR|UxRTN|LkCwOVUh|ryP MXfTRW5ITVJ?
IST-MES1 NFfacHpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2POfGlEPTB;M{SuNFU1OSEQvF2= MXjTRW5ITVJ?
A4-Fuk MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYPJR|UxRTN3LkC2OkDPxE1? NHm4bHRUSU6JRWK=
CAL-85-1 NUfRNJlDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUHEeW5OUUN3ME2zOU4zQDF5IN88US=> MVTTRW5ITVJ?
CCRF-CEM MkXhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3HCfWlEPTB;M{euNVU{PiEQvF2= Mlv3V2FPT0WU
HAL-01 M4HQZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXnET4xnUUN3ME2zPE41QDh7IN88US=> Mnq4V2FPT0WU
HEL MnvYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2mxZWlEPTB;NEOuN|QxQSEQvF2= M1\SR3NCVkeHUh?=
EW-1 MonWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlXjTWM2OD12Mz60O|Y5KM7:TR?= MlHPV2FPT0WU
MDA-MB-231 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYC4U4lLUUN3ME20OU4yOTl7IN88US=> MlzRV2FPT0WU
ABC-1 NWTI[oJZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFn3UJNKSzVyPUS2Mlg2OzhizszN M3TOfHNCVkeHUh?=
NCI-H446 M1my[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXHiNlRyUUN3ME20PE42ODV6IN88US=> M3rhWnNCVkeHUh?=
MHH-PREB-1 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlLkTWM2OD12OT62NFA4KM7:TR?= NYnsdI8yW0GQR1XS
DOHH-2 M4[yfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlvHTWM2OD12OT62OlU3KM7:TR?= NFjKXWZUSU6JRWK=
GCT MnP0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGGzd2JKSzVyPUS5MlY6PzZizszN M1PRXnNCVkeHUh?=

... Click to View More Cell Line Experimental Data

In vivo 17-AAG displays significantly higher binding affinity for Hsp90 from 3T3-src, B16 or CT26 xenografts in nude mice with IC50 values of 8-35 nM as compared with that from the normal tissues with IC50 values of 200-600 nM. [1] Administration of 17-AAG (~50 mg/kg) causes significant decline in AR, HER2, HER3, and Akt expression in a dose-dependent manner with >50% decline at dose of 50 mg/kg, resulting in the dose-dependent inhibition of androgen-dependent (CWR22) and -independent (CWR22R and CWRSA6) prostate cancer xenografts growth by 67%, 80% and 68% at dose of 50 mg/kg, respectively. [2]

Protocol

Kinase Assay:[1]
+ Expand

Hsp90 binding assays:

Purified native Hsp90 protein or cell lysates from HER-2-overexpressing cancer cells (BT474, N87, SKOV3 and SKBR3) or BT474 breast carcinoma cells in lysis buffer (20 mM HEPES, pH 7.3, 1 mM EDTA, 5 mM MgCl2, 100 mM KCl) are incubated with various concentrations of 17-AAG for 30 minutes at 4 °C, and then incubated with biotin-GM linked to BioMag streptavidin magnetic beads for 1 hour at 4 °C. Tubes are placed on a magnetic rack, and the unbound supernatant removed. The magnetic beads are washed three times in lysis buffer and heated for 5 minutes at 95 °C in SDS–PAGE sample buffer. Samples are analysed on SDS protein gels, and western blots done using indicated antibodies. Bands in the western blots are quantified using the Bio-rad Fluor-S MultiImager, and the percentage inhibition of binding of Hsp90 to the biotin-GM is calculated. The IC50 reported is the concentration of 17-AAG needed to cause half-maximal inhibition of binding.
Cell Research:[1]
+ Expand
  • Cell lines: BT474, SKBR3, N87, SKOV3, MCF7, MDA468, Hs578T, Hs578Bst, A549, HT29, U87, SKMG3, HT1080, RPTEC, NDF, HMVEC, HMEC, HUVEC, and PBMC cells
  • Concentrations: Dissolved in DMSO, final concentrations ~10 μM
  • Incubation Time: 5 days
  • Method: Cells are seeded in 96-well plates at 2,000 cells per well in a final culture volume of 100 μL for 24 hours before the addition of increasing concentrations of 17-AAG that is incubated for 5 days. Viable cell number is determined using the Celltiter 96 AQueous Nonradioactive Cell Proliferation Assay. The value of the background absorbance at 490 nm (A490) of wells not containing cells is subtracted. Percentage of viable cells = (A490 of 17-AAG treated sample/A490 untreated cells) × 100. The IC50 is defined as the concentration that gave rise to 50% viable cell number.
    (Only for Reference)
Animal Research:[2]
+ Expand
  • Animal Models: Male nu/nu athymic mice inoculated s.c. with androgen-dependent CWR22 xenograft, and female nu/nu athymic mice inoculated s.c. with androgen-independent xenografts CWR22R and CWRSA6
  • Formulation: Dissolved in DMSO, and diluted in egg phospholipids (EPL) vehicle
  • Dosages: ~50 mg/kg
  • Administration: Injection i.p.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 100 mg/mL (170.73 mM)
Ethanol 5 mg/mL (8.53 mM)
Water slightly soluble or insoluble
In vivo Add solvents individually and in order:
5%DMSO+corn oil
10mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 585.69
Formula

C31H43N3O8

CAS No. 75747-14-7
Storage powder
in solvent
Synonyms CP127374,NSC-330507, KOS 953

Bio Calculators

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT00577889 Completed Adenocarcinoma of the Pancreas|Recurrent Pancreatic Cancer|Stage IV Pancreatic Cancer National Cancer Institute (NCI) March 2008 Phase 2
NCT00546780 Completed Multiple Myeloma Bristol-Myers Squibb February 2008 Phase 3
NCT00093496 Completed Primary Peritoneal Cavity Cancer|Recurrent Ovarian Epithelial Cancer|Stage III Ovarian Epithelial Cancer|Stage IV Ovarian Epithelial Cancer National Cancer Institute (NCI) October 2007 Phase 2
NCT00514371 Completed Multiple Myeloma Bristol-Myers Squibb August 2007 Phase 2|Phase 3
NCT00779428 Completed Advanced Malignancies Bristol-Myers Squibb July 2006 Phase 2
NCT00354185 Terminated Adult Nasal Type Extranodal NK/T-cell Lymphoma|Anaplastic Large Cell Lymphoma|Angioimmunoblastic T-cell Lymphoma|Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue|Intraocular Lymphoma|Nodal Marginal Zone B-cell Lymphoma|Post-transplant Lymphoproliferative Disorder|Recurrent Adult Burkitt Lymphoma|Recurrent Adult Diffuse Large Cell Lymphoma|Recurrent Adult Diffuse Mixed Cell Lymphoma|Recurrent Adult Diffuse Small Cleaved Cell Lymphoma|Recurrent Adult Grade III Lymphomatoid Granulomatosis|Recurrent Adult Hodgkin Lymphoma|Recurrent Adult Immunoblastic Large Cell Lymphoma|Recurrent Adult Lymphoblastic Lymphoma|Recurrent Adult T-cell Leukemia/Lymphoma|Recurrent Cutaneous T-cell Non-Hodgkin Lymphoma|Recurrent Grade 1 Follicular Lymphoma|Recurrent Grade 2 Follicular Lymphoma|Recurrent Grade 3 Follicular Lymphoma|Recurrent Mantle Cell Lymphoma|Recurrent Marginal Zone Lymphoma|Recurrent Mycosis Fungoides/Sezary Syndrome|Recurrent Small Lymphocytic Lymphoma|Small Intestine Lymphoma|Splenic Marginal Zone Lymphoma|Stage III Adult Burkitt Lymphoma|Stage III Adult Diffuse Large Cell Lymphoma|Stage III Adult Diffuse Mixed Cell Lymphoma|Stage III Adult Diffuse Small Cleaved Cell Lymphoma|Stage III Adult Hodgkin Lymphoma|Stage III Adult Immunoblastic Large Cell Lymphoma|Stage III Adult Lymphoblastic Lymphoma|Stage III Adult T-cell Leukemia/Lymphoma|Stage III Cutaneous T-cell Non-Hodgkin Lymphoma|Stage III Grade 1 Follicular Lymphoma|Stage III Grade 2 Follicular Lymphoma|Stage III Grade 3 Follicular Lymphoma|Stage III Mantle Cell Lymphoma|Stage III Marginal Zone Lymphoma|Stage III Mycosis Fungoides/Sezary Syndrome|Stage III Small Lymphocytic Lymphoma|Stage IV Adult Burkitt Lymphoma|Stage IV Adult Diffuse Large Cell Lymphoma|Stage IV Adult Diffuse Mixed Cell Lymphoma|Stage IV Adult Diffuse Small Cleaved Cell Lymphoma|Stage IV Adult Hodgkin Lymphoma|Stage IV Adult Immunoblastic Large Cell Lymphoma|Stage IV Adult Lymphoblastic Lymphoma|Stage IV Adult T-cell Leukemia/Lymphoma|Stage IV Cutaneous T-cell Non-Hodgkin Lymphoma|Stage IV Grade 1 Follicular Lymphoma|Stage IV Grade 2 Follicular Lymphoma|Stage IV Grade 3 Follicular Lymphoma|Stage IV Mantle Cell Lymphoma|Stage IV Marginal Zone Lymphoma|Stage IV Mycosis Fungoides/Sezary Syndrome|Stage IV Small Lymphocytic Lymphoma|Unspecified Adult Solid Tumor, Protocol Specific|Waldenström Macroglobulinemia National Cancer Institute (NCI) May 2006 Phase 1

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID