Research Area
Product Type
United States ( Change Country )
17-DMAG HCl (Alvespimycin) Chemical Structure
Elesclomol
HSP-70 Inducer
AUY922 (NVP-AUY922)
NVP-AUY922 (VER-52296) is a highly potent HSP90 inhibitor to HSP90α and HSP90β with IC50 of 13 nM and 21 nM, respectively.
17-AAG (Geldanamycin)
17-AAG (Geldanamycin) is a less toxic analogue of the geldanamycin which binds to Hsp90 and alters its function.
Ganetespib (STA-9090)
Ganetespib is a unique triazolone-containing Hsp90 inhibitor with an IC50 of 4 nM for OSA 8 cells.
AT13387
AT13387 is a selective potent small molecule heat shock protein 90 (Hsp90) inhibitor for A375, MV4-11, NCI-H1975 and SKBr3 cell lines with IC50 of 18 nM, 12 nM, 22 nM and 55 nM, respectively.
BIIB021
BIIB021 is an inhibitor of Hsp90(Ki=1.7nM).
MPC-3100
MPC-3100 is a fully synthetic potent small-molecule Hsp90 inhibitor with an IC50 of 60 nM.
NVP-BEP800
NVP-BEP800 is a novel, fully synthetic, oral Hsp90 inhibitor with an IC50 of 0.058 ± 0.006 μM.
SNX-2112
SNX-2112 is a potent synthetic heat shock protein 90 inhibitor with an IC50 of 0.92 μM for K562 cells.
PF-04929113 (SNX-5422)
PF-04929113 (SNX-5422) is a potent and selective Hsp90 inhibitor with an IC50 of median 50 nM.
Biological Activity
17-DMAG HCl (Alvespimycin), a watersoluble geldanamycin analog belonging to the class of benzoquinones, is a selective Hsp90 inhibitor. 17-DMAG HCl binds to the N-terminal domain ATP binding site of Hsp90, inhibiting Hsp90 chaperone activity. 17-DMAG HCl demonstrates greater potency and water solubility than other geldanamycin analogs such as 17-AAG (mean GI50 values are 53 and 123 nM for 17-DMAG HCl and 17-AAG respectively), while demonstrating anti-tumor activity and offering excellent oral bioavailability. [1]
References on 17-DMAG HCl (Alvespimycin)
- [1] Cancer Chemother Pharmacol 2005;56: 126–137
Product Information
| Molecular Weight (WM): | 653.21 |
|---|---|
| Formula: | C32H48N4O8•HCl |
| CAS No.: | 467214-21-7 |
| Synonyms: |
NSC 707545
|
| Dissolve in (25°C): | DMSO ≥131mg/mL |
| Water ≥3mg/mL | |
| Ethanol <1mg/mL | |
| Storage: | 2 years-20°CPowder |
| 1 week-4°Cin DMSO | |
| 1 month-80°in DMSO |
Quality Control & MSDS
Research Area
Related Inhibitors
Recommended Screening Libraries
Chemical Library
A collection of 864 bioactive compounds
Inhibitor Library
A collection of 481 inhibitors
Kinase Inhibitor Library
A collection of 194 kinase inhibitors
Tyrosine Kinase Inhibitor Library
A collection of 85 tyrosine kinase inhibitors.
FDA Approved Drug Library
A collection of 426 FDA approved drugs
Natural Product Library
A collection of 139 natural products
Chemotherapeutic Agent Library
A collection of 40 chemotherapeutic agents
Epigenetics Compound library
A unique collection of 17 small molecule modulators
Stem Cell Compound library
A unique collection of 47 small molecule inhibitors
GPCR Compound library
A unique collection of 63 GPCR small molecules
Keywords:buy 17-DMAG HCl (Alvespimycin) | 17-DMAG HCl (Alvespimycin) supplier | purchase 17-DMAG HCl (Alvespimycin) | 17-DMAG HCl (Alvespimycin) cost | 17-DMAG HCl (Alvespimycin) manufacturer | order 17-DMAG HCl (Alvespimycin) | 17-DMAG HCl (Alvespimycin) distributor