Nitrofural

Catalog No.S1644

Nitrofural is a topical anti-infective agent with an IC50 of 22.83 ± 1.2 μM. (Rat LD50 = 590 mg/kg)

Price Stock Quantity  
In DMSO USD 190 In stock
USD 97 In stock
USD 370 In stock
Bulk Inquiry

Massive Discount Available

Free Overnight Delivery on all orders over $ 500.

Nitrofural Chemical Structure

Nitrofural Chemical Structure
Molecular Weight: 198.14

Validation & Quality Control

Quality Control & MSDS

Related Compound Libraries

Nitrofural is available in the following compound libraries:

Product Information

Product Description

Biological Activity

Nitrofurazone is a topical anti-infective agent with an IC50 of 22.83 ± 1.2 µM, and effective against gram-negative and gram-positive bacteria. (Rat LD50 = 590 mg/kg)[1] Nitrofurazone (NF) and its derivative, hydroxymethylnitrofurazone (NFOH), have presented antichagasic activity. In vitro cruzain inhibition tests were performed for both compounds, and the 50% inhibitory concentration (IC50) for NF and NFOH presented values of 22.83 ± 1.2 µM and 10.55 ± 0.81 µM, respectively. AM1 semi-empirical molecular modeling studies were performed to understand the activity of the compounds, corroborating the observed cruzain inhibitory activity. [2]

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

SpeciesMouseRatRabbitGuinea pigHamsterDogMonkeyBaboon
Weight (kg)0.020.151.80.40.0810312
Body Surface Area (m2)0.0070.0250.150.050.020.50.240.6
Km factor361285201220
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Rat dose (mg/kg) = mouse dose (22.4 mg/kg) ×  mouse Km(3)  = 11.2 mg/kg
rat Km(6)

Chemical Information

Download Nitrofural SDF
Molecular Weight (MW) 198.14
Formula

C6H6N4O4

CAS No. 59-87-0
Storage 3 years -20℃powder
6 months-80℃in solvent
Synonyms Nitrofurazone
Solubility (25°C) * In vitro DMSO 40 mg/mL (201.87 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Chemical Name 2-​[(5-​nitro-​2-​furanyl)​methylene]​-hydrazinecarboxamide

Research Area

Tech Support & FAQs

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

* Indicates a Required Field

Related Others Products

  • Puromycin 2HCl

    Puromycin 2HCl is an aminonucleoside antibiotic, which acts as a protein synthesis inhibitor.

  • BAPTA-AM

    BAPTA-AM is a selective, membrane-permeable calcium chelator.

  • Pepstatin A

    Pepstatin A is a potent aspartic protease inhibitor, and also inhibits HIV replication.

  • CX-4945 (Silmitasertib)

    CX-4945 (Silmitasertib) is a potent and selective inhibitor of CK2 (casein kinase 2) with IC50 of 1 nM, less potent to Flt3, Pim1 and CDK1 (inactive in cell-based assay). Phase 1/2.

    Features:First clinical inhibitor of CK2.

  • Cyclosporin A

    Cyclosporin A is an immunosuppressive agent, binds to the cyclophilin and then inhibits calcineurin with IC50 of 7 nM, widely used in organ transplantation to prevent rejection.

  • Ganciclovir

    Ganciclovir is an antiviral drug for feline herpesvirus type-1 with IC50 of 5.2 μM.

  • Cyclophosphamide Monohydrate

    Cyclophosphamide Monohydrate is a nitrogen mustard alkylating agent, it attaches the alkyl group to the guanine base of DNA.

  • Calcitriol

    Calcitriol is the hormonally active form of vitamin D.

  • 4μ8C

    4μ8C is a potent and selective IRE1 Rnase inhibitor with IC50 of 76 nM.

  • (-)-Epigallocatechin Gallate

    (-)-Epigallocatechin Gallate is the main catechin extraction of green tea, which shows multiple bioactivity.

Recently Viewed Items

Tags: buy Nitrofural | Nitrofural ic50 | Nitrofural price | Nitrofural cost | Nitrofural solubility dmso | Nitrofural purchase | Nitrofural manufacturer | Nitrofural research buy | Nitrofural order | Nitrofural mouse | Nitrofural chemical structure | Nitrofural mw | Nitrofural molecular weight | Nitrofural datasheet | Nitrofural supplier | Nitrofural in vitro | Nitrofural cell line | Nitrofural concentration | Nitrofural nmr
Contact Us