Nitrofural

Catalog No.S1644

Nitrofural is a topical anti-infective agent with an IC50 of 22.83 ± 1.2 μM. (Rat LD50 = 590 mg/kg)

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In DMSO USD 190 In stock
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USD 370 In stock
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Nitrofural Chemical Structure

Nitrofural Chemical Structure
Molecular Weight: 198.14

Validation & Quality Control

Quality Control & MSDS

Related Compound Libraries

Nitrofural is available in the following compound libraries:

Product Information

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Product Description

Biological Activity

Nitrofurazone is a topical anti-infective agent with an IC50 of 22.83 ± 1.2 µM, and effective against gram-negative and gram-positive bacteria. (Rat LD50 = 590 mg/kg)[1] Nitrofurazone (NF) and its derivative, hydroxymethylnitrofurazone (NFOH), have presented antichagasic activity. In vitro cruzain inhibition tests were performed for both compounds, and the 50% inhibitory concentration (IC50) for NF and NFOH presented values of 22.83 ± 1.2 µM and 10.55 ± 0.81 µM, respectively. AM1 semi-empirical molecular modeling studies were performed to understand the activity of the compounds, corroborating the observed cruzain inhibitory activity. [2]

Clinical Trial Information( data from http://clinicaltrials.gov)

NCT Number Recruitment Conditions Sponsor
/Collaborators
Start Date Phases
NCT00192985 Active, not recruiting Trauma|Urinary Tract Infections Rigshospitalet, Denmark 2003-05 Phase 3
NCT00669747 Recruiting Ductal Carcinoma In Situ Windy Hill Medical, Inc. 2008-05 Phase 2
NCT02099240 Not yet recruiting Osteomyelitis University of Louisville|Julio Ramirez|James Graham Brown Cancer Center 2014-04 Phase 0

Chemical Information

Download Nitrofural SDF
Molecular Weight (MW) 198.14
Formula

C6H6N4O4

CAS No. 59-87-0
Storage 3 years -20℃Powder
6 months-80℃in DMSO
Synonyms Nitrofurazone
Solubility (25°C) * In vitro DMSO 40 mg/mL (201 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Research Area

Tech Support & FAQs

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