Ascomycin (FK520)

Catalog No.S7411 Synonyms: FR 900520, Immunomycin

Ascomycin (FK520) Chemical Structure

Molecular Weight(MW): 792.01

Ascomycin (FK520), an FK-506 analog, is a neutral macrolide immunosuppressant, which prevents rejection after an organ transplant. Phase 3.

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Biological Activity

Description Ascomycin (FK520), an FK-506 analog, is a neutral macrolide immunosuppressant, which prevents rejection after an organ transplant. Phase 3.
Targets
calcineurin phosphatase [2]
49 nM
In vitro

Ascomycin, isolated from Streptomyces, suppresses immune response in vitro with IC50 of 0.55 nM for mouse mixed lymphocyte. [1] Ascomycin inhibits calcineurin phosphatase with IC50 of 49 nM through formation of an FKBP12-FK520-calcineurin ternary complex. FK520 also accelerate the rate of nerve regeneration, and promotes neurite outgrowth. [2] Ascomycin shows antimalarial effects via inhibition of the chaperone activity of this bifunctional protein. [3]

In vivo Ascomycin (3.2 mg/kg, i.m.) clearly prolongs skin allograft survival in rats. [1] Ascomycin, at 50 or 100 μM, produces anticonvulsant effect against picrotoxin-induced seizures when infused into the rat hippocampus. [4]

Protocol

Animal Research:[1]
+ Expand
  • Animal Models: Recipient WKA rats transplanted with F344 skin allografts.
  • Formulation: Olive oil
  • Dosages: ~32 mg/kg 5 days a week.
  • Administration: i.m.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 100 mg/mL (126.26 mM)
Ethanol 100 mg/mL (126.26 mM)
Water slightly soluble or insoluble
In vivo Add solvents individually and in order:

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 792.01
Formula

C43H69NO12

CAS No. 104987-12-4
Storage powder
in solvent
Synonyms FR 900520, Immunomycin

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID