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p-Coumaric Acid

Name: p-Coumaric Acid
Brand: Selleck Chemicals
SKU: S4759
Rating: 5 (2 reviews)

Synonyms: 4-Hydroxycinnamic acid, P-Hydroxycinnamic acid, 4-Coumaric acid, Trans-p-Coumaric acid, para-Coumaric Acid

Catalog No.S4759 Purity: 99.76%

p-Coumaric acid (4-Hydroxycinnamic acid, P-Hydroxycinnamic acid, 4-Coumaric acid, Trans-p-Coumaric acid, para-Coumaric Acid) is a hydroxy derivative of cinnamic acid found in a variety of edible plants and is reported to have antioxidant, anti-inflammatory, and antimicrobial activity.

p-Coumaric Acid Chemical Structure

CAS: 501-98-4

Selleck's p-Coumaric Acid has been cited by 2 publications

Purity & Quality Control

Batch: Purity: 99.76%

99.76

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Biological Activity

Description	p-Coumaric acid (4-Hydroxycinnamic acid, P-Hydroxycinnamic acid, 4-Coumaric acid, Trans-p-Coumaric acid, para-Coumaric Acid) is a hydroxy derivative of cinnamic acid found in a variety of edible plants and is reported to have antioxidant, anti-inflammatory, and antimicrobial activity.

In vitro
In vitro	p-Coumaric acid is the most abundant isomer in natureand is biosynthesized from cinnamic acid by the action ofthe P450-dependent enzyme 4-cinnamic acid hydroxylase. p-Coumaric acid possesses antioxidant properties that reduce the risk of stomachcancer by suppressing the formation of carcinogenic nitrosamines. p-coumaric acid effectively suppressed endo-thelial cell migration, tube formation, and rat aorta ring sprouting. It reduces intracellular andmitochondrial reactive oxygen species production^[1].
Cell Research	Cell lines	ECV304 cells
	Concentrations	0-5 mM
	Incubation Time	24 h
	Method	ECV304 cells were seededat a concentration of 6.0 ×10⁴ cells/cm₂ onto 24-well plates. After specific treatment for 24 h, a ﬁnal concentration of 0.5 mg/mL MTT reagent was added directly toeach well. After 2 h, the medium was removed, the formazan crystals in ECV304 cells were dissolved in dimethylsulfoxide, and the absorbance of the formazan solutionwas measured by an ELISA reader at 540 nm.

In Vivo
In vivo	p-coumaric acid signif-icantly suppressed tumor growth in vivo by blockingangiogenesis^[1].
Animal Research	Animal Models	Male BALB/c mice
	Dosages	150 mg/kg
	Administration	i.p.

References

[1] Kong CS, et al. Phytother Res. 2013, 27(3):317-23.

Chemical Information & Solubility

Molecular Weight	164.16	Formula	C₉H₈O₃
CAS No.	501-98-4	SDF	Download p-Coumaric Acid SDF
Smiles	C1=CC(=CC=C1C=CC(=O)O)O
Storage (From the date of receipt)	3 years-20°Cpowder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years-20°Cpowder		1 month-20°Cin solvent

In vitro
Batch:

DMSO : 32 mg/mL ( (194.93 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 32 mg/mL

Water : Insoluble

Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.

In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

Dilution Calculator Molecular Weight Calculator

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg Average weight of animals: g Dosing volume per animal:μL Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO + % + % Tween 80 + % ddH₂O

%DMSO+ %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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