Chlorquinaldol Chemical Structure

Chlorquinaldol Chemical Structure
Molecular Weight: 228.07

Validation & Quality Control

Quality Control & MSDS

Product Information

Product Description

Biological Activity

Description Chlorquinaldol is an antimicrobial agent used for local antisepsy.
In vitro Chlorquinaldol is a derivative of hydroxy-8-quinolein. For 0.1 to 0.2% (W/V) chlorquinaldol concentrations, a reduction of about 104 organisms is obtained after 60 minutes for N. gonorrhoeae and C. trachomatis. However, for technical problems, the concentrations tested are 10 to 100 times lower than the doses usually recommended for this antiseptic. [1] Chlorquinaldol displays enhanced bactericidal activity in duodeno-pancreatic secretions. [2]
In vivo
Features

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

SpeciesMouseRatRabbitGuinea pigHamsterDog
Weight (kg)0.020.151.80.40.0810
Body Surface Area (m2)0.0070.0250.150.050.020.5
Km factor36128520
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Rat dose (mg/kg) = mouse dose (22.4 mg/kg) ×  mouse Km(3)  = 11.2 mg/kg
rat Km(6)
1

References

[1] Corrihons I, et al. Pathol Biol (Paris), 1991, 39(2), 136-139.

[2] Mett H, et al. Antimicrob Agents Chemother, 1984, 26(1), 35-38.

Chemical Information

Download Chlorquinaldol SDF
Molecular Weight (MW) 228.07
Formula

C10H7Cl2NO

CAS No. 72-80-0
Storage 3 years -20℃powder
6 months-80℃in solvent
Synonyms N/A
Solubility (25°C) * In vitro DMSO 46 mg/mL (201.69 mM)
Ethanol 6 mg/mL (26.3 mM)
Water <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Chemical Name 8-Quinolinol, 5,7-dichloro-2-methyl-

Tech Support & FAQs

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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