Isradipine

Catalog No.S1662 Synonyms: PN 200-110

Isradipine Chemical Structure

Molecular Weight(MW): 371.39

Isradipine is a potent and selective L-type voltage-gated calcium channel blocker, used to treat high blood pressure.

Size Price Stock Quantity  
In DMSO USD 90 In stock
USD 70 In stock
USD 150 In stock
USD 270 In stock
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Biological Activity

Description Isradipine is a potent and selective L-type voltage-gated calcium channel blocker, used to treat high blood pressure.
Targets
Calcium channel [1]
In vitro

Isradipine produces inhibition of both growth cultures and oxygen consumption on epimastigotes of Trypanosoma cruzi Tulahuen strain, at micromolar concentrations. Isradipine is found to be the most potent derivative in both, in growth cultures (I50 = 20.8 mM) and in vivo oxygen uptake (I50 = 31.1 mM). [1]

In vivo Isradipine reduces hypoxia-induced activation of calcium dependent xanthine oxidases, monoamine oxidases, cytosolic phospholipase A(2) and cyclooxygenases (COX-2) along with concomitant decrease in free radical generation and cytochrome c release. Isradipine prevents hypobaric hypoxia along with augmented neurodegeneration and memory impairment induced increased expression of calpain and caspase 3. [2] Isradipine (at the dose of 1 mg/kg three times a day) reduces ethanol intake by over 70% in ethanol-preferring rats, the reduction in ethanol intake is compensated by a proportional increase in water consumption and the inhibitory effect persisted throughout the 5 days of treatment. [3] Isradipine significantly reduces the arterial wall collagen contents in both strains, with marked increases in the elastin content in the carotid but not in the aortic wall in spontaneously hypertensive rats. [4] Isradipine suppresses the reinforcing properties of morphine and cocaine and may be an effective pharmacotherapy for treatment of cocaine and heroin abuse in mice. [5]

Protocol

Solubility (25°C)

In vitro DMSO 74 mg/mL (199.25 mM)
Ethanol 74 mg/mL warmed (199.25 mM)
Water Insoluble
In vivo Add solvents to the product individually and in order:
2% DMSO+corn oil
10mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 371.39
Formula

C19H21N3O5

CAS No. 75695-93-1
Storage powder
Synonyms PN 200-110

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02168842 Active, not recruiting Parkinson Disease University of Rochester|National Institute of Neurological Disorders and Stroke (NINDS)|Michael J. Fox Foundation for Parkinsons Research|The Parkinson Study Group September 2014 Phase 3
NCT01895270 Completed Opioid Dependence University of Arkansas|National Institute on Drug Abuse (NIDA) October 2013 Phase 1|Phase 2
NCT01784666 Unknown status Bipolar Disorder Massachusetts General Hospital February 2013 Phase 2
NCT01658150 Recruiting Schizophrenia|Schizoaffective Disorder Icahn School of Medicine at Mount Sinai|Brain & Behavior Research Foundation September 2012 --
NCT01007994 Completed Hypertension Secondary to Kidney Transplant Northwell Health|Childrens Hospital of Philadelphia November 2009 Phase 2|Phase 3
NCT00909545 Completed Parkinson Disease Northwestern University|Michael J. Fox Foundation for Parkinsons Research|Northwestern University Dixon Fund|The Parkinson Study Group July 2009 Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID