Catalog No.S1662 Synonyms: PN 200-110

Isradipine Chemical Structure

Molecular Weight(MW): 371.39

Isradipine is a potent and selective L-type voltage-gated calcium channel blocker, used to treat high blood pressure.

Size Price Stock Quantity  
In DMSO USD 90 In stock
USD 70 In stock
USD 150 In stock
USD 270 In stock
Bulk Discount

Free Overnight Delivery on orders over $ 500
Next day delivery by 10:00 a.m. Order now.

Purity & Quality Control

Choose Selective Calcium Channel Inhibitors

Biological Activity

Description Isradipine is a potent and selective L-type voltage-gated calcium channel blocker, used to treat high blood pressure.
Calcium channel [1]
In vitro

Isradipine produces inhibition of both growth cultures and oxygen consumption on epimastigotes of Trypanosoma cruzi Tulahuen strain, at micromolar concentrations. Isradipine is found to be the most potent derivative in both, in growth cultures (I50 = 20.8 mM) and in vivo oxygen uptake (I50 = 31.1 mM). [1]

In vivo Isradipine reduces hypoxia-induced activation of calcium dependent xanthine oxidases, monoamine oxidases, cytosolic phospholipase A(2) and cyclooxygenases (COX-2) along with concomitant decrease in free radical generation and cytochrome c release. Isradipine prevents hypobaric hypoxia along with augmented neurodegeneration and memory impairment induced increased expression of calpain and caspase 3. [2] Isradipine (at the dose of 1 mg/kg three times a day) reduces ethanol intake by over 70% in ethanol-preferring rats, the reduction in ethanol intake is compensated by a proportional increase in water consumption and the inhibitory effect persisted throughout the 5 days of treatment. [3] Isradipine significantly reduces the arterial wall collagen contents in both strains, with marked increases in the elastin content in the carotid but not in the aortic wall in spontaneously hypertensive rats. [4] Isradipine suppresses the reinforcing properties of morphine and cocaine and may be an effective pharmacotherapy for treatment of cocaine and heroin abuse in mice. [5]


Solubility (25°C)

In vitro DMSO 74 mg/mL (199.25 mM)
Ethanol 74 mg/mL warmed (199.25 mM)
Water Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
2% DMSO+corn oil
For best results, use promptly after mixing.

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 371.39


CAS No. 75695-93-1
Storage powder
in solvent
Synonyms PN 200-110

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

  • Mass
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03083353 Suspended Nicotine Dependence University of Texas at Austin January 2020 Early Phase 1
NCT02168842 Active not recruiting Parkinson Disease University of Rochester|National Institute of Neurological Disorders and Stroke (NINDS)|Michael J. Fox Foundation for Parkinson''s Research|The Parkinson Study Group September 2014 Phase 3
NCT01895270 Completed Opioid Dependence University of Arkansas|National Institute on Drug Abuse (NIDA) October 2013 Phase 1|Phase 2
NCT01784666 Terminated Bipolar Disorder Massachusetts General Hospital February 2013 Phase 2
NCT01658150 Completed Schizophrenia|Schizoaffective Disorder Icahn School of Medicine at Mount Sinai|Brain & Behavior Research Foundation September 2012 Not Applicable
NCT01007994 Active not recruiting Hypertension Secondary to Kidney Transplant Northwell Health|Children''s Hospital of Philadelphia November 2009 Phase 2|Phase 3

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

Calcium Channel Signaling Pathway Map

Related Calcium Channel Products

Tags: buy Isradipine | Isradipine supplier | purchase Isradipine | Isradipine cost | Isradipine manufacturer | order Isradipine | Isradipine distributor
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID