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ROCK Inhibitors (5)


Cat.No. Product Name Information Product Citations Customer Reviews
S1049 Y-27632 2HCl Y-27632 2HCl is a selective ROCK1 (p160ROCK) inhibitor with Ki of 140 nM, exhibits >200-fold selectivity over other kinases, including PKC, cAMP-dependent protein kinase, MLCK and PAK.
  • Cell Res, 2013, 23(10):1187-200
  • Proc Natl Acad Sci U S A, 2013, 110(52):E5039-48
  • Proc Natl Acad Sci U S A, 2014, 10.1073/pnas.1319738111
S1459 Thiazovivin Thiazovivin (Tzv) is a novel ROCK inhibitor with IC50 of 0.5 μM, promotes hESC survival after single-cell dissociation.
  • Cell Res, 2013, 23(10):1187-200
  • Arch Toxicol, 2013, 87(12):2215-31
  • Cell Reprogram, 2012, 14(6):485-96
S1573 Fasudil (HA-1077) HCl Fasudil (HA-1077) is a potent inhibitor of ROCK-II, PKA, PKG, PKC, and MLCK with Ki of 0.33 μM, 1.6 μM, 1.6 μM, 3.3 μM and 36 μM, respectively.
  • J Clin Invest, 2014, 124(4):1646-59
  • Diabetes, 2013, 62(5):1697-708
  • FEBS Lett, 2014, 10.1016/j.febslet.2014.02.041
S1474 GSK429286A GSK429286A is a selective inhibitor of ROCK1 and ROCK2 with IC50 of 14 nM and 63 nM, respectively.
  • Proc Natl Acad Sci U S A, 2014, 10.1073/pnas.1402515111
S7195 RKI-1447 RKI-1447 is a potent inhibitor of ROCK1 and ROCK2, with IC50 of 14.5 nM and 6.2 nM, respectively, has anti-invasive and antitumor activities.