ROCK

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ROCK Inhibitors (6)

water-soluble

Cat.No. Product Name Information Product Use Citation Customer Product Validation
S1049 Y-27632 2HCl Y-27632 2HCl is a selective ROCK1 (p160ROCK) inhibitor with Ki of 140 nM, exhibits >200-fold selectivity over other kinases, including PKC, cAMP-dependent protein kinase, MLCK and PAK.
  • Cell Res, 2013, 23(10):1187-200
  • Proc Natl Acad Sci U S A, 2014, 111(12):4484-9
  • Proc Natl Acad Sci U S A, 2013, 110(52):E5039-48
S1459 Thiazovivin Thiazovivin is a novel ROCK inhibitor with IC50 of 0.5 μM, promotes hESC survival after single-cell dissociation.
  • Cell Res, 2013, 23(10):1187-200
  • Arch Toxicol, 2013, 87(12):2215-31
  • Am J Cancer Res, 2014, 6(6):724-735
S1573 Fasudil (HA-1077) HCl Fasudil (HA-1077) is a potent inhibitor of ROCK-II, PKA, PKG, PKC, and MLCK with Ki of 0.33 μM, 1.6 μM, 1.6 μM, 3.3 μM and 36 μM, respectively.
  • J Clin Invest, 2014, 124(9):3757-66
  • J Clin Invest, 2014, 124(4):1646-59
  • Diabetes, 2013, 62(5):1697-708
S1474 GSK429286A GSK429286A is a selective inhibitor of ROCK1 and ROCK2 with IC50 of 14 nM and 63 nM, respectively.
  • Proc Natl Acad Sci U S A, 2014, 111(12):E1140-8
  • Am J Respir Cell Mol Biol, 2014, 50(1):170-9
  • PLoS One, 2014, 9(1):e87281
S7195 RKI-1447 RKI-1447 is a potent inhibitor of ROCK1 and ROCK2, with IC50 of 14.5 nM and 6.2 nM, respectively, has anti-invasive and antitumor activities.
S7563 AT13148 AT13148 is an oral, ATP-competitive, multi-AGC kinase inhibitor with IC50 of 38 nM/402 nM/50 nM, 8 nM, 3 nM, and 6 nM/4 nM for Akt1/2/3, p70S6K, PKA, and ROCKI/II, respectively. Phase 1.

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Cat.No. Product Name Solubility (25°C)
Water DMSO Ethanol
S1049 Y-27632 2HCl 32 mg/mL 64 mg/mL <1 mg/mL
S1459 Thiazovivin <1 mg/mL 15 mg/mL <1 mg/mL
S1573 Fasudil (HA-1077) HCl 65 mg/mL 5 mg/mL <1 mg/mL
S1474 GSK429286A <1 mg/mL 87 mg/mL 4 mg/mL
S7195 RKI-1447 <1 mg/mL 65 mg/mL <1 mg/mL
S7563 AT13148 <1 mg/mL 62 mg/mL <1 mg/mL
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