Netarsudil (AR-13324) 2HCl

Catalog No.S8226

Netarsudil (AR-13324) 2HCl Chemical Structure

Molecular Weight(MW): 526.45

Netarsudil (a.k.a. AR-13324) is ROCK inhibitor with Ki value of 0.2-10.3 nM. It is currently in clinical trials for the treatment of glaucoma and ocular hypertension.

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Biological Activity

Description Netarsudil (a.k.a. AR-13324) is ROCK inhibitor with Ki value of 0.2-10.3 nM. It is currently in clinical trials for the treatment of glaucoma and ocular hypertension.
Targets
norepinephrine transporter (NET) [3] ROCK [1]
2 nM(Ki)
In vivo Netarsudil primarily targets cells in the conventional outflow tract, efficiently decreasing IOP in both human and non-human primate eyes. In addition, netarsudil has been shown to increase outflow facility in non-human primate eyes and to decrease episcleral venous pressure in rabbit eyes[2].

Protocol

Solubility (25°C)

In vitro Water 54 mg/mL (102.57 mM)
DMSO 20 mg/mL (37.99 mM)
Ethanol 2 mg/mL (3.79 mM)

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 526.45
Formula

C28H27N3O3.2HCl

CAS No. 1253952-02-1
Storage powder
Synonyms N/A

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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Related Antibodies

ROCK Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID