GSK269962 HCl

Catalog No.S7687 Synonyms: GSK269962A, GSK269962B

GSK269962 HCl Chemical Structure

Molecular Weight(MW): 607.06

GSK269962 is a selective ROCK(Rho-associated protein kinase) inhibitor with IC50 values of 1.6 and 4 nM for ROCK1 and ROCK2, respectively.

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Purity & Quality Control

Choose Selective ROCK Inhibitors

Biological Activity

Description GSK269962 is a selective ROCK(Rho-associated protein kinase) inhibitor with IC50 values of 1.6 and 4 nM for ROCK1 and ROCK2, respectively.
Targets
ROCK1 [1]
(Cell-free assay)
ROCK2 [1]
(Cell-free assay)
MSK1 [1]
(Cell-free assay)
RSK1 [1]
(Cell-free assay)
1.6 nM 4 nM 49 nM 132 nM
In vitro

GSK269962A completely abolished the actin stress fiber formation induced by angiotensin II in human smooth muscles. Such suppressive effect on actin fiber formation was observed beginning at around 1 μM GSK269962A. GSK269962A induced vasorelaxation in preconstricted rat aorta(tissue baths) with an IC50 of 35 nM. the relaxation induced by GSK269962A is reversible. GSK269962A suppressed IL-6 mRNA transcription and reduced LPS-induced IL-6 and TNF-α protein production in macrophages[1].

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
NCI-H1581 M4PH[mdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NIXVPGxKdmirYnn0bY9vKG:oIHj1cYFvKE6FST3INVU5OSClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTF6Lki0O|ch|ryP M2D1b3NCVkeHUh?=
NCI-H1694 NFnp[ZRIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NIrqVHFKdmirYnn0bY9vKG:oIHj1cYFvKE6FST3INVY6PCClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTJ2Lki3OFkh|ryP NGW3T5ZUSU6JRWK=
NCI-H1963 MkL1S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NHnSd|FKdmirYnn0bY9vKG:oIHj1cYFvKE6FST3INVk3OyClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTFwMke4N|kh|ryP NFXLdIdUSU6JRWK=
NCI-H2081 MXnHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MmjXTY5pcWKrdHnvckBw\iCqdX3hckBPS0lvSEKwPFEh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0{PC54MES0JO69VQ>? M{CwU3NCVkeHUh?=
NCI-H209 M4npVWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MVHJcohq[mm2aX;uJI9nKGi3bXHuJG5EUS2KMkC5JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NlIvPjJ5MjFOwG0> MWHTRW5ITVJ?
NCI-H2107 MV;Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MmrXTY5pcWKrdHnvckBw\iCqdX3hckBPS0lvSEKxNFch[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0zPS54NU[xJO69VQ>? NYnNbnFRW0GQR1XS
NCI-H2126 M2X3cmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M4fEUmlvcGmkaYTpc44hd2ZiaIXtZY4hVkOLLViyNVI3KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:Pi53MESyOkDPxE1? Mo\tV2FPT0WU
NCI-H2171 NGDMbm9Iem:5dHigbY5pcWKrdHnvckBie3OjeR?= MmXoTY5pcWKrdHnvckBw\iCqdX3hckBPS0lvSEKxO|Eh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0xNjl3OUO3JO69VQ>? MYXTRW5ITVJ?
NCI-H2227 MUjHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MonqTY5pcWKrdHnvckBw\iCqdX3hckBPS0lvSEKyNlch[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF04Njh6NkG2JO69VQ>? NEDPOWdUSU6JRWK=
NCI-H524 NG[xbIpIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NUPaeHV6UW6qaXLpeIlwdiCxZjDoeY1idiCQQ1mtTFUzPCClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTJ{Lki3OlMh|ryP NFe4S2VUSU6JRWK=
NCI-H526 M1f2RWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M{XrdmlvcGmkaYTpc44hd2ZiaIXtZY4hVkOLLVi1NlYh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yQC53NEOxJO69VQ>? M3;DfHNCVkeHUh?=
NCI-H720 MXHHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NXjTdVJmUW6qaXLpeIlwdiCxZjDoeY1idiCQQ1mtTFczOCClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTJwNEWxOlEh|ryP NFnNbZVUSU6JRWK=
NMC-G1 NF;aSpZIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NHfHSWJKdmirYnn0bY9vKG:oIHj1cYFvKE6PQz3HNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVE2NjB3N{ig{txO M1PISXNCVkeHUh?=
NOS-1 cell M13wdGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MmjSTY5pcWKrdHnvckBw\iCqdX3hckBPV1NvMTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUWuPFIzQTRizszN MXjTRW5ITVJ?
OCI-AML2 cell MkfSS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M2\qVmlvcGmkaYTpc44hd2ZiaIXtZY4hV0OLLVHNUFIh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yOC57NEm2JO69VQ>? NU\QcoYyW0GQR1XS
OCUB-M cell M1TSU2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MVvJcohq[mm2aX;uJI9nKGi3bXHuJG9EXUJvTTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUG3MlIxOSEQvF2= NXnPbo1{W0GQR1XS
ONS-76 cell M2HBO2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NGP1b4pKdmirYnn0bY9vKG:oIHj1cYFvKE:QUz23OkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVE{NjlzOUGg{txO NHTZXZJUSU6JRWK=
OS-RC-2 cell NG\FNIJIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NXrZ[ZhOUW6qaXLpeIlwdiCxZjDoeY1idiCRUz3SR{0zKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:PDZwMUm1JO69VQ>? NVfBSYV4W0GQR1XS
OVCAR-4 cell M{LvOmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NFr3S2JKdmirYnn0bY9vKG:oIHj1cYFvKE:YQ1HSMVQh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF05NjdzOEC4JO69VQ>? MmnHV2FPT0WU
P30-OHK cell NX;LfVBCT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MnrwTY5pcWKrdHnvckBw\iCqdX3hckBROzBvT1jLJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9O{43Ojh5NzFOwG0> M2fPOXNCVkeHUh?=
P30-OHK cell MUXHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MUXJcohq[mm2aX;uJI9nKGi3bXHuJHBHNTN6MjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUeuNFQ6PTRizszN M4TjWnNCVkeHUh?=
PSN1 cell MUnHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NYq4eIhFUW6qaXLpeIlwdiCxZjDoeY1idiCSU16xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Ok4zOjF{NjFOwG0> NXviNllsW0GQR1XS
QIMR-WIL cell MXTHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NWL6b2hXUW6qaXLpeIlwdiCxZjDoeY1idiCTSV3SMXdKVCClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTBwNEmwNFQh|ryP MV3TRW5ITVJ?
RCC10RGB cell MnH5S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MnHCTY5pcWKrdHnvckBw\iCqdX3hckBTS0NzMGLHRkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVE5NjlyM{[g{txO NF7E[YZUSU6JRWK=
RKO cell NYnzXHgzT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M1TBR2lvcGmkaYTpc44hd2ZiaIXtZY4hWkuRIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MUCuOVY3OiEQvF2= NGOxTFBUSU6JRWK=
RL95-2 cell MX7Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MXvJcohq[mm2aX;uJI9nKGi3bXHuJHJNQTVvMjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGwMlY4KM7:TR?= MmPEV2FPT0WU
RPMI-6666 cell MkDnS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MnT3TY5pcWKrdHnvckBw\iCqdX3hckBTWE2LLU[2OlYh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yQC53MkO2JO69VQ>? M{DBWXNCVkeHUh?=
RPMI-8402 cell M4my[2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M{ewNGlvcGmkaYTpc44hd2ZiaIXtZY4hWlCPST24OFAzKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:PC53OEW2JO69VQ>? NFu1epJUSU6JRWK=
RXF393 cell Mk\mS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MX7Jcohq[mm2aX;uJI9nKGi3bXHuJHJZTjN7MzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUCuN|k{KM7:TR?= NHrLeW9USU6JRWK=
Ramos-2G6-4C10 cell NHq3TI9Iem:5dHigbY5pcWKrdHnvckBie3OjeR?= NGWzZXZKdmirYnn0bY9vKG:oIHj1cYFvKFKjbX;zMVJIPi12Q{GwJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU4{PTdizszN MXLTRW5ITVJ?
SCLC-21H cell NFL4S2JIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NXvKcINRUW6qaXLpeIlwdiCxZjDoeY1idiCVQ1zDMVIyUCClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTdwNkGxOFkh|ryP M4PlTnNCVkeHUh?=
SF126 cell NYTvSJpbT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MoPmTY5pcWKrdHnvckBw\iCqdX3hckBUTjF{NjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGxMlg{OjIQvF2= NV7lUXc{W0GQR1XS
SF268 cell M{T1XGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MVnJcohq[mm2aX;uJI9nKGi3bXHuJHNHOjZ6IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Nj6yN|E5OyEQvF2= NEDvSJlUSU6JRWK=
SF539 cell NYrsVmRnT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NYLtTnlIUW6qaXLpeIlwdiCxZjDoeY1idiCVRkWzPUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEvOjh4NkGg{txO NIPTcGNUSU6JRWK=
SH-4 cell NVjrO3p1T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NF36b5lKdmirYnn0bY9vKG:oIHj1cYFvKFOKLUSgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME21Mlc2PTB6IN88US=> MYHTRW5ITVJ?
SIG-M5 cell NEXLcplIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MXfJcohq[mm2aX;uJI9nKGi3bXHuJHNKTy2PNTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGxMlczPTlizszN M4Pm[HNCVkeHUh?=
SJSA-1 cell MUnHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NGjISlRKdmirYnn0bY9vKG:oIHj1cYFvKFOMU1GtNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEvODR3Mk[g{txO MXrTRW5ITVJ?
SK-LMS-1 cell MkLMS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NGGzbVBKdmirYnn0bY9vKG:oIHj1cYFvKFONLVzNV{0yKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OzJwNUm2OUDPxE1? MWTTRW5ITVJ?
SK-MM-2 cell MlvrS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MojpTY5pcWKrdHnvckBw\iCqdX3hckBUUy2PTT2yJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9OFIvOzRyNTFOwG0> NXHyc5FEW0GQR1XS
SK-N-DZ cell MlvHS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MXzJcohq[mm2aX;uJI9nKGi3bXHuJHNMNU5vRGqgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME25MlQ5OzF2IN88US=> NYHke5V4W0GQR1XS
SK-NEP-1 cell M3;tNWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M{nsZ2lvcGmkaYTpc44hd2ZiaIXtZY4hW0tvTlXQMVEh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yPy53NEW2JO69VQ>? M3W2eXNCVkeHUh?=
SK-PN-DW cell MmLsS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NV3DXIV2UW6qaXLpeIlwdiCxZjDoeY1idiCVSz3QUk1FXyClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTJ2Lkm3N|Yh|ryP NVG4V2FVW0GQR1XS
SNB75 cell MY\Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MoG3TY5pcWKrdHnvckBw\iCqdX3hckBUVkJ5NTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUiuNFc4OzdizszN M4n6SXNCVkeHUh?=
SR cell MoP1S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MkTKTY5pcWKrdHnvckBw\iCqdX3hckBUWiClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTBwMECwNVM4KM7:TR?= M3\DXXNCVkeHUh?=
SU-DHL-1 cell Mn\iS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MXjJcohq[mm2aX;uJI9nKGi3bXHuJHNWNUSKTD2xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NVIvPzN|NjFOwG0> NYLv[HliW0GQR1XS
SW684 cell NFXjVoNIem:5dHigbY5pcWKrdHnvckBie3OjeR?= Mn7GTY5pcWKrdHnvckBw\iCqdX3hckBUXzZ6NDDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUO5MlAyOSEQvF2= Mn;EV2FPT0WU
SW872 cell NFq3PYxIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M4ixb2lvcGmkaYTpc44hd2ZiaIXtZY4hW1d6N{KgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2wMlg5PjV4IN88US=> MXvTRW5ITVJ?
SW962 cell MnGzS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MVLJcohq[mm2aX;uJI9nKGi3bXHuJHNYQTZ{IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MUKuO|UzOSEQvF2= M{[2RXNCVkeHUh?=
697 cell NFi2RZhIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MVXJcohq[mm2aX;uJI9nKGi3bXHuJFY6PyClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTBwMkm5NUDPxE1? NGfR[IxUSU6JRWK=
8-MG-BA cell NIP2[YZIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M3jrSGlvcGmkaYTpc44hd2ZiaIXtZY4hQC2PRz3CRUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVI{NjB5OUOg{txO MXzTRW5ITVJ?
A101D cell NGLV[YZIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NVnjSFY2UW6qaXLpeIlwdiCxZjDoeY1idiCDMUCxSEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEvQDdyM{Sg{txO M4XJenNCVkeHUh?=
ACN cell M{P0VWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NFHqUoVKdmirYnn0bY9vKG:oIHj1cYFvKEGFTjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUKxMlQ{QDdizszN NIixPI5USU6JRWK=
AM-38 cell MWTHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MlH6TY5pcWKrdHnvckBw\iCqdX3hckBCVS1|ODDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUeuNlY{OjdizszN NX;4NY9oW0GQR1XS
ATN-1 cell NYjyeodPT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NGLjRmpKdmirYnn0bY9vKG:oIHj1cYFvKEGWTj2xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NlQvPzV3NTFOwG0> NVjnW4MzW0GQR1XS
BB30-HNC cell MkPlS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NV7WcFFHUW6qaXLpeIlwdiCxZjDoeY1idiCEQkOwMWhPSyClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTJ{LkK1N|Ih|ryP M2PiWHNCVkeHUh?=
BB49-HNC cell M4OxUmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NWfqO|U4UW6qaXLpeIlwdiCxZjDoeY1idiCEQkS5MWhPSyClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTBwMEC3PFkh|ryP NFL3eXFUSU6JRWK=
human BC-1 cell MkjJS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NFXvdWpKdmirYnn0bY9vKG:oIHj1cYFvKEKFLUGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2zMlk4OTB5IN88US=> MnGwV2FPT0WU
BE-13 cell MoWzS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MoHYTY5pcWKrdHnvckBw\iCqdX3hckBDTS1zMzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUCuNVQxQDIQvF2= NWrmWnVqW0GQR1XS
BL-70 cell MYnHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NIL5eodKdmirYnn0bY9vKG:oIHj1cYFvKEKOLUewJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9N{41ODdyMzFOwG0> MkLCV2FPT0WU
BV-173 cell NF3yTWhIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MXTJcohq[mm2aX;uJI9nKGi3bXHuJGJXNTF5MzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUG4Mlg5PTlizszN NGPrTVdUSU6JRWK=
Becker cell MW\Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NEHVTpVKdmirYnn0bY9vKG:oIHj1cYFvKEKnY3vldkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVE{Njl3NEWg{txO MXjTRW5ITVJ?
CAL-148 cell Mo[1S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MnT1TY5pcWKrdHnvckBw\iCqdX3hckBESUxvMUS4JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9N|UvPjV3NzFOwG0> MoLTV2FPT0WU
TE-10 cell NEHXS3dIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MVPJcohq[mm2aX;uJI9nKGi3bXHuJHRGNTFyIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MkKuPFQzOyEQvF2= M3HtRXNCVkeHUh?=
TE-12 cell MX7Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MnLqTY5pcWKrdHnvckBw\iCqdX3hckBVTS1zMjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUOyMlQyOTRizszN M37ZPXNCVkeHUh?=
TE-8 cell MXzHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NY\LeWFrUW6qaXLpeIlwdiCxZjDoeY1idiCWRT24JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NVEvPjB6OTFOwG0> NYjaVW9XW0GQR1XS
TE-9 cell M2T6RWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M3\5XmlvcGmkaYTpc44hd2ZiaIXtZY4hXEVvOTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUO2MlY{QDFizszN MmryV2FPT0WU
TGW cell MnrkS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MV\Jcohq[mm2aX;uJI9nKGi3bXHuJHRIXyClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTJ|LkO1O|ch|ryP MXPTRW5ITVJ?
UACC-257 cell MWjHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M3;6OmlvcGmkaYTpc44hd2ZiaIXtZY4hXUGFQz2yOVch[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF05NjdyNkK1JO69VQ>? NEnXVpVUSU6JRWK=
WSU-NHL cell MX3Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M{GyUGlvcGmkaYTpc44hd2ZiaIXtZY4hX1OXLV7IUEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVI4NjF7MEeg{txO NUPwTGdiW0GQR1XS
no-10 cell NILiWGFIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M1HYdmlvcGmkaYTpc44hd2ZiaIXtZY4hdm9vMUCgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2wMlY3QDR4IN88US=> NELW[5NUSU6JRWK=
no-11 cell NEfxSZRIem:5dHigbY5pcWKrdHnvckBie3OjeR?= Mlq5TY5pcWKrdHnvckBw\iCqdX3hckBvdy1zMTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUS3MlAzPjNizszN Mlr4V2FPT0WU
CAS-1 cell NHy1cHZIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MoHWTY5pcWKrdHnvckBw\iCqdX3hckBESVNvMTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUCuPFQ4KM7:TR?= NFHiZotUSU6JRWK=
CCRF-CEM cell MUHHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MWXJcohq[mm2aX;uJI9nKGi3bXHuJGNEWkZvQ1XNJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9PE43PTN7MjFOwG0> MULTRW5ITVJ?
CMK cell NGnJRW9Iem:5dHigbY5pcWKrdHnvckBie3OjeR?= M1nmUGlvcGmkaYTpc44hd2ZiaIXtZY4hS02NIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MT6wNVMzOyEQvF2= NGX3UZJUSU6JRWK=
COLO-829 cell MXfHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MX;Jcohq[mm2aX;uJI9nKGi3bXHuJGNQVE9vOEK5JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9N{4zPDJ{NjFOwG0> NVuxO5lKW0GQR1XS
COR-L279 cell NXf4UJNqT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NFLNT5NKdmirYnn0bY9vKG:oIHj1cYFvKEORUj3MNlc6KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:Oi5yN{O4JO69VQ>? M4npe3NCVkeHUh?=
CP66-MEL cell Ml2wS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MWnJcohq[mm2aX;uJI9nKGi3bXHuJGNRPjZvTVXMJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9N|YvPTR7NzFOwG0> NF6yTXBUSU6JRWK=
CRO-AP2 cell MWrHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M3vCWmlvcGmkaYTpc44hd2ZiaIXtZY4hS1KRLVHQNkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIvOzZyOEig{txO M4HzfnNCVkeHUh?=
CTV-1 cell M4TiNGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MUXJcohq[mm2aX;uJI9nKGi3bXHuJGNVXi1zIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MkOuPVE1PSEQvF2= NXjjRmd1W0GQR1XS
Calu-6 cell NIH1b|ZIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MYfJcohq[mm2aX;uJI9nKGi3bXHuJGNidHVvNjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUS3MlU5PiEQvF2= NXL1e3Y2W0GQR1XS
D-247MG cell NYXzfFR6T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= Ml\kTY5pcWKrdHnvckBw\iCqdX3hckBFNTJ2N13HJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NE43OjhzNDFOwG0> NE\SSFBUSU6JRWK=
D-263MG cell MVHHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M4Tic2lvcGmkaYTpc44hd2ZiaIXtZY4hTC1{NkPNS{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVAvODh3MEmg{txO NUnBOJZoW0GQR1XS
D-336MG cell NXS3[3Z5T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NYHyeoJUUW6qaXLpeIlwdiCxZjDoeY1idiCGLUOzOm1IKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OC54Mki1OEDPxE1? NVjUUFRUW0GQR1XS
D-392MG cell Mn\tS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MWDJcohq[mm2aX;uJI9nKGi3bXHuJGQuOzl{TVegZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlQ{ODN7IN88US=> NHvNVm9USU6JRWK=
D-502MG cell MXnHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MXjJcohq[mm2aX;uJI9nKGi3bXHuJGQuPTB{TVegZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME24MlU{PDl{IN88US=> M1P4TnNCVkeHUh?=
D-542MG cell MW\Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NWrnWWVRUW6qaXLpeIlwdiCxZjDoeY1idiCGLUW0Nm1IKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OTJwM{G1NkDPxE1? Mn[0V2FPT0WU
DB cell M1vHSGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MYjJcohq[mm2aX;uJI9nKGi3bXHuJGRDKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:PDdwMUSxO{DPxE1? M2PaUXNCVkeHUh?=
DEL cell NGji[lRIem:5dHigbY5pcWKrdHnvckBie3OjeR?= Ml7CTY5pcWKrdHnvckBw\iCqdX3hckBFTUxiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD15LkCxPFk5KM7:TR?= M3W2THNCVkeHUh?=
DMS-114 cell M3rsdGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M2ftPWlvcGmkaYTpc44hd2ZiaIXtZY4hTE2VLUGxOEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVQ6Njh2Nkig{txO MYjTRW5ITVJ?
DMS-153 cell MVfHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MX7Jcohq[mm2aX;uJI9nKGi3bXHuJGROWy1zNUOgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME20Nk46QTJ|IN88US=> NGTONIdUSU6JRWK=
DOHH-2 cell M2DDeGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MXPJcohq[mm2aX;uJI9nKGi3bXHuJGRQUEhvMjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUSuNlI4PjRizszN MX7TRW5ITVJ?
DSH1 cell M4rRVmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NF21ZY5KdmirYnn0bY9vKG:oIHj1cYFvKESVSEGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME24MlQ{PjJ|IN88US=> M4rlVnNCVkeHUh?=
Daudi cell MXPHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NGXxfWVKdmirYnn0bY9vKG:oIHj1cYFvKESjdXTpJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Nk4xQThyMjFOwG0> M1fNZ3NCVkeHUh?=
EC-GI-10 cell MX;Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MVXJcohq[mm2aX;uJI9nKGi3bXHuJGVENUeLLUGwJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9OFQvOjV6OTFOwG0> NXr6dXR7W0GQR1XS
ECC4 cell NH3vPFRIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NU\Vc20xUW6qaXLpeIlwdiCxZjDoeY1idiCHQ1O0JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9N|IvOTh7NjFOwG0> NGT4VJFUSU6JRWK=
EM-2 cell MWfHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MUjJcohq[mm2aX;uJI9nKGi3bXHuJGVONTJiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1{LkS1OVk1KM7:TR?= MXjTRW5ITVJ?
ES1 cell MXfHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NIHWN3BKdmirYnn0bY9vKG:oIHj1cYFvKEWVMTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUWuOVQxQDdizszN M3vhbXNCVkeHUh?=
ES3 cell M1\mU2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M3KySGlvcGmkaYTpc44hd2ZiaIXtZY4hTVN|IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;NEKuOFczQSEQvF2= MoLlV2FPT0WU
ES4 cell MkW2S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M1\ITmlvcGmkaYTpc44hd2ZiaIXtZY4hTVN2IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;M{WuNVk2KM7:TR?= NULMU2h7W0GQR1XS
ES6 cell MXTHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M4q4PGlvcGmkaYTpc44hd2ZiaIXtZY4hTVN4IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MD6yOFc{OyEQvF2= M3vZfHNCVkeHUh?=
ES7 cell NFrKfXNIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NYfqWFN3UW6qaXLpeIlwdiCxZjDoeY1idiCHU{egZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME21MlI{OTJ2IN88US=> NXLnWmoyW0GQR1XS
ES8 cell MoCyS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MYLJcohq[mm2aX;uJI9nKGi3bXHuJGVUQCClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTBwOEG5NlQh|ryP M{HJRnNCVkeHUh?=
EW-18 cell NHj3d5NIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NILDfm5KdmirYnn0bY9vKG:oIHj1cYFvKEWZLUG4JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NVMvPjd3OTFOwG0> NIfNVGhUSU6JRWK=
EW-22 cell NWLrTmhjT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= Mn7ETY5pcWKrdHnvckBw\iCqdX3hckBGXy1{MjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUS3Mlc6PDdizszN NFjtOJNUSU6JRWK=
GCIY cell NVX5bmJ7T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MWHJcohq[mm2aX;uJI9nKGi3bXHuJGdEUVliY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD17LkiwN|g6KM7:TR?= MVrTRW5ITVJ?
GDM-1 cell MWLHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MmroTY5pcWKrdHnvckBw\iCqdX3hckBITE1vMTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUiuN|kyQTZizszN MWDTRW5ITVJ?
GI-1 cell M1Lu[2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NFzQTWFKdmirYnn0bY9vKG:oIHj1cYFvKEeLLUGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2wMlAxPTJ|IN88US=> M2DiTXNCVkeHUh?=
GI-ME-N cell NXPTZpVyT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M1r2W2lvcGmkaYTpc44hd2ZiaIXtZY4hT0lvTVWtUkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVAvODR7NUGg{txO MkTTV2FPT0WU
GR-ST cell M3jYPGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MVrJcohq[mm2aX;uJI9nKGi3bXHuJGdTNVOWIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MUOuO|kxOiEQvF2= MUHTRW5ITVJ?
GT3TKB cell MVvHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MXfJcohq[mm2aX;uJI9nKGi3bXHuJGdVO1SNQjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGuOlA{QDlizszN M3HidHNCVkeHUh?=
HAL-01 cell NFXidIxIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NULrbVEyUW6qaXLpeIlwdiCxZjDoeY1idiCKQVytNFEh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF03NjZ7N{GyJO69VQ>? NW[1UXNyW0GQR1XS
HCC1599 cell NFTpcplIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NF;WeW5KdmirYnn0bY9vKG:oIHj1cYFvKEiFQ{G1PVkh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0{Py54MEGxJO69VQ>? NWm0OFBxW0GQR1XS
HCC2218 cell MYHHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NHjpRXBKdmirYnn0bY9vKG:oIHj1cYFvKEiFQ{KyNVgh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yOy5|OEO0JO69VQ>? NInVRo9USU6JRWK=
HD-MY-Z cell NI\3U2ZIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NG[zXGtKdmirYnn0bY9vKG:oIHj1cYFvKEiGLV3ZMXoh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0zPS5{MUS2JO69VQ>? NGLMW29USU6JRWK=
HL-60 cell NH:4dnpIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MnnuTY5pcWKrdHnvckBw\iCqdX3hckBJVC14MDDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGyMlIyOTRizszN MkLTV2FPT0WU
HOP-62 cell NVjqOm9{T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= Mmf1TY5pcWKrdHnvckBw\iCqdX3hckBJV1BvNkKgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yN{46PTJ5IN88US=> NUnTS3VuW0GQR1XS
HT cell M2C5emdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NVPnVJQ{UW6qaXLpeIlwdiCxZjDoeY1idiCKVDDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUSuOFQ{OjFizszN NGLDO4tUSU6JRWK=
HT-144 cell NGO2RVdIem:5dHigbY5pcWKrdHnvckBie3OjeR?= Mli5TY5pcWKrdHnvckBw\iCqdX3hckBJXC1zNESgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME20MlkxPjh4IN88US=> MkXUV2FPT0WU
HUTU-80 cell Ml;zS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MorPTY5pcWKrdHnvckBw\iCqdX3hckBJXVSXLUiwJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9N{44QDl6NjFOwG0> NYr5fm5tW0GQR1XS
IST-MEL1 cell M4\KVmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NWDNPHRHUW6qaXLpeIlwdiCxZjDoeY1idiCLU2StUWVNOSClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTN{LkmwPFYh|ryP NWDJS|RSW0GQR1XS
IST-SL1 cell MlyzS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M4D1OmlvcGmkaYTpc44hd2ZiaIXtZY4hUVOWLWPMNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIvOTdyN{mg{txO MkHKV2FPT0WU
IST-SL2 cell MUDHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NHrkO5hKdmirYnn0bY9vKG:oIHj1cYFvKEmVVD3TUFIh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0{NjJ4NkC4JO69VQ>? NYTE[5ZiW0GQR1XS
K052 cell MoPjS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MVTJcohq[mm2aX;uJI9nKGi3bXHuJGsxPTJiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1yLke1N|AyKM7:TR?= M33hZXNCVkeHUh?=
K5 cell MXjHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M4PnZWlvcGmkaYTpc44hd2ZiaIXtZY4hUzViY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1|Mz61PVE2KM7:TR?= M32w[HNCVkeHUh?=
KALS-1 cell Ml3yS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NUXIUJR[UW6qaXLpeIlwdiCxZjDoeY1idiCNQVzTMVEh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0zQS5|OU[5JO69VQ>? MojYV2FPT0WU
KARPAS-422 cell NWnmNI1YT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MVLJcohq[mm2aX;uJI9nKGi3bXHuJGtCWlCDUz20NlIh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF01Oi57MUSyJO69VQ>? NYrK[lFEW0GQR1XS
KARPAS-45 cell NGHpVlJIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NILNWVRKdmirYnn0bY9vKG:oIHj1cYFvKEuDUmDBV{01PSClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTRwMUGyOFch|ryP NWfqPYp6W0GQR1XS
KE-37 cell NYnJemlQT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MVHJcohq[mm2aX;uJI9nKGi3bXHuJGtGNTN5IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;OT64N|Uh|ryP MWTTRW5ITVJ?
KG-1 cell MYXHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NEPRcoJKdmirYnn0bY9vKG:oIHj1cYFvKEuJLUGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yN{46PzV5IN88US=> MWnTRW5ITVJ?
KGN cell Mm\RS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M4rOb2lvcGmkaYTpc44hd2ZiaIXtZY4hU0eQIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MD61Olc1OiEQvF2= NWr0WWJUW0GQR1XS
KM12 cell NHqyNmdIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NVzsOIJ{UW6qaXLpeIlwdiCxZjDoeY1idiCNTUGyJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9N{42Ojl4NDFOwG0> NYXEcpk4W0GQR1XS
KMOE-2 cell MkjJS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M2DHdGlvcGmkaYTpc44hd2ZiaIXtZY4hU02RRT2yJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9N|AvPDV2OTFOwG0> MnvSV2FPT0WU
KNS-42 cell MUXHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MYDJcohq[mm2aX;uJI9nKGi3bXHuJGtPWy12MjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUiuPFE6OTVizszN M1HsdHNCVkeHUh?=
KNS-81-FD cell MmjKS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MkHhTY5pcWKrdHnvckBw\iCqdX3hckBMVlNvOEGtSmQh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0{Py52Mk[g{txO M2O0V3NCVkeHUh?=
KS-1 cell Mo\BS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NWDKdo03UW6qaXLpeIlwdiCxZjDoeY1idiCNUz2xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NE4xODR4IN88US=> MVzTRW5ITVJ?
KU812 cell MXnHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NF[yZYZKdmirYnn0bY9vKG:oIHj1cYFvKEuXOEGyJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NlMvPDh2IN88US=> M1uxZnNCVkeHUh?=
L-540 cell MnPWS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NUPjW4FMUW6qaXLpeIlwdiCxZjDoeY1idiCOLUW0NEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIxNjd2NEWg{txO NVnN[WQxW0GQR1XS
LAMA-84 cell M3\yWGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MX;Jcohq[mm2aX;uJI9nKGi3bXHuJGxCVUFvOESgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xN{43PzR{IN88US=> NGTMbWhUSU6JRWK=
LB1047-RCC cell NYnSW4ZXT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NIX2OpVKdmirYnn0bY9vKG:oIHj1cYFvKEyEMUC0O{1TS0NiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1{OD6zPFg{KM7:TR?= NX\OZZZ[W0GQR1XS
LB2241-RCC cell NV2yWG44T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MWTJcohq[mm2aX;uJI9nKGi3bXHuJGxDOjJ2MT3SR2Mh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yOC53NUO2JO69VQ>? NYK4OmFYW0GQR1XS
LB2518-MEL cell M4SzU2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MWXJcohq[mm2aX;uJI9nKGi3bXHuJGxDOjVzOD3NSWwh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yNjdzNEm2{txO NV;M[IpxW0GQR1XS
LB831-BLC cell M4XBc2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MUfJcohq[mm2aX;uJI9nKGi3bXHuJGxDQDNzLVLMR{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEyNjF5Mk[g{txO MlToV2FPT0WU
LB996-RCC cell NYTPdo44T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M3HFTGlvcGmkaYTpc44hd2ZiaIXtZY4hVEJ7OU[tVmNEKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OTJwN{SzNUDPxE1? M3Hyb3NCVkeHUh?=
LC4-1 cell MnLhS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M3Li[WlvcGmkaYTpc44hd2ZiaIXtZY4hVEN2LUGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2zNk45OzRzIN88US=> NHXUNHlUSU6JRWK=
LOUCY cell NE\XZYpIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NUK5d4dtUW6qaXLpeIlwdiCxZjDoeY1idiCOT2XDXUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEvOTV{N{[g{txO M{PqNHNCVkeHUh?=
LOXIMVI cell MXfHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M3TCZmlvcGmkaYTpc44hd2ZiaIXtZY4hVE:[SV3WTUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVMxNjJzMkKg{txO NH32cVdUSU6JRWK=
LS-123 cell MnX6S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NIDBfGlKdmirYnn0bY9vKG:oIHj1cYFvKEyVLUGyN{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVM6NjJ{NUig{txO MmXxV2FPT0WU
LU-134-A cell M3TqbWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NIL2d4pKdmirYnn0bY9vKG:oIHj1cYFvKEyXLUGzOE1CKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:Py5zNEC2PEDPxE1? MY\TRW5ITVJ?
LU-139 cell NWrRNmpNT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NIn4UWpKdmirYnn0bY9vKG:oIHj1cYFvKEyXLUGzPUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIzNjJzODFOwG0> NVv2Tm1FW0GQR1XS
LXF-289 cell NWH1[XU6T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= Mni3TY5pcWKrdHnvckBw\iCqdX3hckBNYEZvMki5JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NVcvPDN3Md88US=> MXnTRW5ITVJ?
MC116 cell M{ixbGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M2\iUGlvcGmkaYTpc44hd2ZiaIXtZY4hVUNzMU[gZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME20OU4xQDRzIN88US=> M1vIW3NCVkeHUh?=
MDA-MB-134-VI cell NUPrfpZYT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MXnJcohq[mm2aX;uJI9nKGi3bXHuJG1FSS2PQj2xN|QuXkliY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1|OT6yOFg3KM7:TR?= MWHTRW5ITVJ?
MFH-ino cell NIn4bYZIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MVjJcohq[mm2aX;uJI9nKGi3bXHuJG1HUC2rbn:gZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2wMlY1Ozh|IN88US=> NUXaNoRoW0GQR1XS
MHH-NB-11 cell M33VWGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MU\Jcohq[mm2aX;uJI9nKGi3bXHuJG1JUC2QQj2xNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVAvODZ4OTFOwG0> NUHrcoZTW0GQR1XS
ML-2 cell MVHHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NWDGdFVXUW6qaXLpeIlwdiCxZjDoeY1idiCPTD2yJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9N{41ODNyNDFOwG0> NFHZUIZUSU6JRWK=
MOLT-13 cell MorxS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NYXpSmFOUW6qaXLpeIlwdiCxZjDoeY1idiCPT1zUMVE{KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:PC52M{[1N{DPxE1? MlnvV2FPT0WU
MOLT-16 cell MmnnS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NWH4WHVnUW6qaXLpeIlwdiCxZjDoeY1idiCPT1zUMVE3KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:PC5zMUG2N{DPxE1? Moq5V2FPT0WU
MOLT-4 cell NIXqVoxIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NHTI[|ZKdmirYnn0bY9vKG:oIHj1cYFvKE2RTGStOEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVE1NjRzMkSg{txO MXnTRW5ITVJ?
MPP-89 cell Ml\5S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NUfNUplqUW6qaXLpeIlwdiCxZjDoeY1idiCPUGCtPFkh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yNjJ3OUKyJO69VQ>? NE\JcmRUSU6JRWK=
MRK-nu-1 cell NFvuNndIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M1fjeGlvcGmkaYTpc44hd2ZiaIXtZY4hVVKNLX71MVEh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0xNjV5NUeyJO69VQ>? Mm\HV2FPT0WU
MSTO-211H cell MkC5S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MWHJcohq[mm2aX;uJI9nKGi3bXHuJG1UXE9vMkGxTEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEzNjh4OTFOwG0> MUTTRW5ITVJ?
MV-4-11 cell M3zBb2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MlzVTY5pcWKrdHnvckBw\iCqdX3hckBOXi12LUGxJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NE4yOzlzNTFOwG0> MonsV2FPT0WU
NALM-6 cell NE\tRZBIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NVrYUZVOUW6qaXLpeIlwdiCxZjDoeY1idiCQQVzNMVYh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yNjV4MUC5JO69VQ>? MW\TRW5ITVJ?
NB1 cell M2PmeWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NFvwXJBKdmirYnn0bY9vKG:oIHj1cYFvKE6EMTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUOuPFQ{PjlizszN MknKV2FPT0WU
NB10 cell NXvx[|BRT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MlrYTY5pcWKrdHnvckBw\iCqdX3hckBPSjFyIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MD6xN|kyPSEQvF2= NYTS[HhjW0GQR1XS
NB12 cell M1;Femdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NYHsSlk1UW6qaXLpeIlwdiCxZjDoeY1idiCQQkGyJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NVYvPTZ3NjFOwG0> NH7ab4pUSU6JRWK=
NB13 cell MYnHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NIHzfnFKdmirYnn0bY9vKG:oIHj1cYFvKE6EMUOgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yMlMyOjd6IN88US=> NH32eIJUSU6JRWK=
NB17 cell NUPFcWp1T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NF;qOJJKdmirYnn0bY9vKG:oIHj1cYFvKE6EMUegZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2zMlU5ODVzIN88US=> NIHHdlRUSU6JRWK=
NB6 cell MYXHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NGnSVlZKdmirYnn0bY9vKG:oIHj1cYFvKE6ENjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUCuOVkyOTRizszN NXv2N2pvW0GQR1XS
NCCIT cell MlXqS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NIPJVXpKdmirYnn0bY9vKG:oIHj1cYFvKE6FQ1nUJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9OFEvQDR3MzFOwG0> NF75T5RUSU6JRWK=
NCI-H1155 cell NUSxOYxUT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M1fybGlvcGmkaYTpc44hd2ZiaIXtZY4hVkOLLVixNVU2KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OTRwM{SwPEDPxE1? Ml3lV2FPT0WU
NCI-H1304 cell NYHBXnBPT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M{K0eWlvcGmkaYTpc44hd2ZiaIXtZY4hVkOLLVixN|A1KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OTFwOEm4NkDPxE1? NW\EO5lwW0GQR1XS
NCI-H1355 cell NFzRR|NIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M3zueGlvcGmkaYTpc44hd2ZiaIXtZY4hVkOLLVixN|U2KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:PC57NEGxJO69VQ>? MV\TRW5ITVJ?
NCI-H1395 cell MXrHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MWHJcohq[mm2aX;uJI9nKGi3bXHuJG5EUS2KMUO5OUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIzNjh5OUWg{txO NFXxb3BUSU6JRWK=
NCI-H1417 cell MWXHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NYDKR|lJUW6qaXLpeIlwdiCxZjDoeY1idiCQQ1mtTFE1OTdiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD13Lk[3OVIzKM7:TR?= NGTofodUSU6JRWK=
NCI-H1436 cell NYTTO3pjT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MXTJcohq[mm2aX;uJI9nKGi3bXHuJG5EUS2KMUSzOkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVMvQDRzMEGg{txO M1[4U3NCVkeHUh?=
NTERA-S-cl-D1 cell MlfmS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MUjJcohq[mm2aX;uJI9nKGi3bXHuJG5VTVKDLWOtZ4wuTDFiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1zMj64PVM2KM7:TR?= MknkV2FPT0WU
JiyoyeP-2003 cell Mn7hS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NHr5TWdKdmirYnn0bY9vKG:oIHj1cYFvKEqreX;5[XAuOjByMzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUO2MlYzQDRizszN M1zUNnNCVkeHUh?=

... Click to View More Cell Line Experimental Data

In vivo Oral administration of GSK269962A produced a profound dose-dependent reduction of systemic blood pressure in spontaneously hypertensive rats. The reduction of blood pressure was acute and substantial. The maximal effect on blood pressure was observed approximately 2 h after oral gavages. The reduction of blood pressure was accompanied by an acute, dose-dependent increase in heart rate, presumably due to the activation of baroreflex mechanism[1]. ROCK inhibition with the use of GSK 269962 in the 10 mg/kg dose, in turn, triggered an increase in VV(voided volume), PVR(post-void residual), VT(volume threshold), VE(voiding efficiency), ICI(intercontraction interval), BC(bladder compliance), and VTNVC(volume threshold to elicit NVC). The inhibition of the ROCK pathway through GSK 269962 appeared to have no effect on either HR(heart rate), SBP(systolic blood pressure), MBP(systolic blood pressure), or DBP(diastolic blood pressure)[2]. NVC:nonvoiding contractions.

Protocol

Cell Research:[1]
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  • Cell lines: Human primary smooth muscle cells
  • Concentrations: 3 μM
  • Incubation Time: 150 min
  • Method: Human primary smooth muscle cells were serum-starved(cells were grown on coverslips, and at approximately 50% confluence, they were serum-starved overnight) and stimulated with AngII (100 nM) for 2 h. ROCK inhibitors (3 μM for SB-772077-B or GSK269962A) were added 30 min before AngII stimulation, and cells were fixed and stained with rhodamine phalloidin. Confocal images of actin stain were obtained.
    (Only for Reference)
Animal Research:[2]
+ Expand
  • Animal Models: female Wistar rats
  • Formulation: saline
  • Dosages: 5 or 10 mg/kg
  • Administration: intra-arterially
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 100 mg/mL (164.72 mM)
Ethanol 6 mg/mL (9.88 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 607.06
Formula

C29H30N8O5.HCl

CAS No. 850664-21-0(free base)
Storage powder
Synonyms GSK269962A, GSK269962B

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

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ROCK Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID