GSK269962 HCl

Catalog No.S7687 Synonyms: GSK269962A, GSK269962B

GSK269962 HCl Chemical Structure

Molecular Weight(MW): 607.06

GSK269962 is a selective ROCK(Rho-associated protein kinase) inhibitor with IC50 values of 1.6 and 4 nM for ROCK1 and ROCK2, respectively.

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Purity & Quality Control

Choose Selective ROCK Inhibitors

Biological Activity

Description GSK269962 is a selective ROCK(Rho-associated protein kinase) inhibitor with IC50 values of 1.6 and 4 nM for ROCK1 and ROCK2, respectively.
Targets
ROCK1 [1]
(Cell-free assay)
ROCK2 [1]
(Cell-free assay)
MSK1 [1]
(Cell-free assay)
RSK1 [1]
(Cell-free assay)
1.6 nM 4 nM 49 nM 132 nM
In vitro

GSK269962A completely abolished the actin stress fiber formation induced by angiotensin II in human smooth muscles. Such suppressive effect on actin fiber formation was observed beginning at around 1 μM GSK269962A. GSK269962A induced vasorelaxation in preconstricted rat aorta(tissue baths) with an IC50 of 35 nM. the relaxation induced by GSK269962A is reversible. GSK269962A suppressed IL-6 mRNA transcription and reduced LPS-induced IL-6 and TNF-α protein production in macrophages[1].

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
NCI-H1581 NITtcIRIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MVjJcohq[mm2aX;uJI9nKGi3bXHuJG5EUS2KMUW4NUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVE5Njh2N{eg{txO NV;YcmFXW0GQR1XS
NCI-H1694 MWfHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M4jOdGlvcGmkaYTpc44hd2ZiaIXtZY4hVkOLLVixOlk1KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OjRwOEe0PUDPxE1? MoP2V2FPT0WU
NCI-H1963 NW\uTFc{T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MV;Jcohq[mm2aX;uJI9nKGi3bXHuJG5EUS2KMUm2N{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEvOjd6M{mg{txO MUfTRW5ITVJ?
NCI-H2081 M33Vd2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NIP0V45KdmirYnn0bY9vKG:oIHj1cYFvKE6FST3INlA5OSClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTN2Lk[wOFQh|ryP M1W3RXNCVkeHUh?=
NCI-H209 M{nOcGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MWDJcohq[mm2aX;uJI9nKGi3bXHuJG5EUS2KMkC5JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NlIvPjJ5MjFOwG0> NFLIOZVUSU6JRWK=
NCI-H2107 M3TIfGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M37MR2lvcGmkaYTpc44hd2ZiaIXtZY4hVkOLLViyNVA4KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OjVwNkW2NUDPxE1? MUfTRW5ITVJ?
NCI-H2126 MULHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MoDMTY5pcWKrdHnvckBw\iCqdX3hckBPS0lvSEKxNlYh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF03NjVyNEK2JO69VQ>? Mmi0V2FPT0WU
NCI-H2171 MU\Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NYnab5N7UW6qaXLpeIlwdiCxZjDoeY1idiCQQ1mtTFIyPzFiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1yLkm1PVM4KM7:TR?= NIHufHhUSU6JRWK=
NCI-H2227 NUDDfXNPT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MUDJcohq[mm2aX;uJI9nKGi3bXHuJG5EUS2KMkKyO{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVcvQDh4MU[g{txO NGTYNmRUSU6JRWK=
NCI-H524 MmrTS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MVvJcohq[mm2aX;uJI9nKGi3bXHuJG5EUS2KNUK0JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NlIvQDd4MzFOwG0> MUnTRW5ITVJ?
NCI-H526 NXzaO|ZiT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NH\HOFBKdmirYnn0bY9vKG:oIHj1cYFvKE6FST3IOVI3KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OThwNUSzNUDPxE1? Mmj3V2FPT0WU
NCI-H720 M4nE[Wdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NHu3cZJKdmirYnn0bY9vKG:oIHj1cYFvKE6FST3IO|IxKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:Oi52NUG2NUDPxE1? M3uxRnNCVkeHUh?=
NMC-G1 MmX4S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NFfmcIJKdmirYnn0bY9vKG:oIHj1cYFvKE6PQz3HNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVE2NjB3N{ig{txO MXHTRW5ITVJ?
NOS-1 cell NYK4[W1zT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M4nKPWlvcGmkaYTpc44hd2ZiaIXtZY4hVk:VLUGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME21MlgzOjl2IN88US=> NXSwXldoW0GQR1XS
OCI-AML2 cell MWnHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MX\Jcohq[mm2aX;uJI9nKGi3bXHuJG9EUS2DTVyyJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NVAvQTR7NjFOwG0> M1jze3NCVkeHUh?=
OCUB-M cell MVjHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MkfFTY5pcWKrdHnvckBw\iCqdX3hckBQS1WELV2gZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xO{4zODFizszN MUPTRW5ITVJ?
ONS-76 cell NV7Gd|FyT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= Ml3LTY5pcWKrdHnvckBw\iCqdX3hckBQVlNvN{[gZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xN{46OTlzIN88US=> NEG0[VNUSU6JRWK=
OS-RC-2 cell MoDOS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? Mne2TY5pcWKrdHnvckBw\iCqdX3hckBQWy2UQz2yJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9OFYvOTl3IN88US=> NVv3PIdiW0GQR1XS
OVCAR-4 cell M3TQOmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NWHRSmR[UW6qaXLpeIlwdiCxZjDoeY1idiCRVlPBVk01KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:QC55MUiwPEDPxE1? Mm\iV2FPT0WU
P30-OHK cell MonuS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NIfKOWhKdmirYnn0bY9vKG:oIHj1cYFvKFB|MD3PTGsh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF04NjZ{OEe3JO69VQ>? NV\PeXc3W0GQR1XS
P30-OHK cell M1r1[Gdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M2XST2lvcGmkaYTpc44hd2ZiaIXtZY4hWEZvM{iyJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9O{4xPDl3NDFOwG0> NYjUd2JxW0GQR1XS
PSN1 cell MUjHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MlLtTY5pcWKrdHnvckBw\iCqdX3hckBRW05zIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Nj6yNlEzPiEQvF2= NXjHTFZlW0GQR1XS
QIMR-WIL cell MX\Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M3\RVmlvcGmkaYTpc44hd2ZiaIXtZY4hWUmPUj3XTWwh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0xNjR7MEC0JO69VQ>? NVzpZZBsW0GQR1XS
RCC10RGB cell NIDHWHNIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NYPvdnc1UW6qaXLpeIlwdiCxZjDoeY1idiCUQ1OxNHJISiClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTF6LkmwN|Yh|ryP NEnFbWFUSU6JRWK=
RKO cell NHPHe5ZIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MmiwTY5pcWKrdHnvckBw\iCqdX3hckBTU09iY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1zMD61OlYzKM7:TR?= NEXoRmNUSU6JRWK=
RL95-2 cell MmXuS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MWHJcohq[mm2aX;uJI9nKGi3bXHuJHJNQTVvMjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGwMlY4KM7:TR?= M4L1[3NCVkeHUh?=
RPMI-6666 cell MYPHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NH7BTYVKdmirYnn0bY9vKG:oIHj1cYFvKFKSTVmtOlY3PiClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTF6LkWyN|Yh|ryP M3fkZnNCVkeHUh?=
RPMI-8402 cell MYTHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? Mnr6TY5pcWKrdHnvckBw\iCqdX3hckBTWE2LLUi0NFIh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF01NjV6NU[g{txO M2TC[3NCVkeHUh?=
RXF393 cell NXTWcWR3T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MY\Jcohq[mm2aX;uJI9nKGi3bXHuJHJZTjN7MzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUCuN|k{KM7:TR?= MX7TRW5ITVJ?
Ramos-2G6-4C10 cell NIfJem9Iem:5dHigbY5pcWKrdHnvckBie3OjeR?= MkXFTY5pcWKrdHnvckBw\iCqdX3hckBT[W2xcz2yS|YuPENzMDDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGuN|U4KM7:TR?= M3nKfnNCVkeHUh?=
SCLC-21H cell M1XPR2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NH3kcoZKdmirYnn0bY9vKG:oIHj1cYFvKFOFTFOtNlFJKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:Py54MUG0PUDPxE1? MoTlV2FPT0WU
SF126 cell NXPxVWNuT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MnLHTY5pcWKrdHnvckBw\iCqdX3hckBUTjF{NjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGxMlg{OjIQvF2= Ml\LV2FPT0WU
SF268 cell MmLzS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M3jNN2lvcGmkaYTpc44hd2ZiaIXtZY4hW0Z{NkigZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME22MlI{OTh|IN88US=> MWfTRW5ITVJ?
SF539 cell NXHkZpZiT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M{C5XmlvcGmkaYTpc44hd2ZiaIXtZY4hW0Z3M{mgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlI5PjZzIN88US=> MkjGV2FPT0WU
SH-4 cell M2Xic2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MmrCTY5pcWKrdHnvckBw\iCqdX3hckBUUC12IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;NT63OVUxQCEQvF2= M1i4e3NCVkeHUh?=
SIG-M5 cell NFTofHBIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MkT1TY5pcWKrdHnvckBw\iCqdX3hckBUUUdvTUWgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xNU44OjV7IN88US=> MlXCV2FPT0WU
SJSA-1 cell NGDMTolIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MXrJcohq[mm2aX;uJI9nKGi3bXHuJHNLW0FvMTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGuNFQ2OjZizszN NFe3OJVUSU6JRWK=
SK-LMS-1 cell M1H6Z2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NX6yT5hLUW6qaXLpeIlwdiCxZjDoeY1idiCVSz3MUXMuOSClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTN{LkW5OlUh|ryP NV71UIxIW0GQR1XS
SK-MM-2 cell NYP4NlFtT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MXjJcohq[mm2aX;uJI9nKGi3bXHuJHNMNU2PLUKgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME20Nk4{PDB3IN88US=> NUDJZ|VCW0GQR1XS
SK-N-DZ cell M2Syfmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MVfJcohq[mm2aX;uJI9nKGi3bXHuJHNMNU5vRGqgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME25MlQ5OzF2IN88US=> NFjzV|dUSU6JRWK=
SK-NEP-1 cell NXfQRnBvT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NWjKbJlsUW6qaXLpeIlwdiCxZjDoeY1idiCVSz3OSXAuOSClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTF5LkW0OVYh|ryP NETHUoVUSU6JRWK=
SK-PN-DW cell MVPHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NWHTWYdCUW6qaXLpeIlwdiCxZjDoeY1idiCVSz3QUk1FXyClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTJ2Lkm3N|Yh|ryP MV7TRW5ITVJ?
SNB75 cell NGHqVmRIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M1zXeGlvcGmkaYTpc44hd2ZiaIXtZY4hW06EN{WgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME24MlA4PzN5IN88US=> Mn\CV2FPT0WU
SR cell MnnXS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M174XmlvcGmkaYTpc44hd2ZiaIXtZY4hW1JiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1yLkCwNFE{PyEQvF2= NGKxRYpUSU6JRWK=
SU-DHL-1 cell MorxS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MYrJcohq[mm2aX;uJI9nKGi3bXHuJHNWNUSKTD2xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NVIvPzN|NjFOwG0> NX;XT|RDW0GQR1XS
SW684 cell M4nUVGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MoHBTY5pcWKrdHnvckBw\iCqdX3hckBUXzZ6NDDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUO5MlAyOSEQvF2= Mke1V2FPT0WU
SW872 cell NYjB[49oT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= Mom1TY5pcWKrdHnvckBw\iCqdX3hckBUXzh5MjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUCuPFg3PTZizszN NHLzV21USU6JRWK=
SW962 cell MVPHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NXnyW4xqUW6qaXLpeIlwdiCxZjDoeY1idiCVV{m2NkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEzNjd3MkGg{txO NFzue2xUSU6JRWK=
697 cell MW\Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MV\Jcohq[mm2aX;uJI9nKGi3bXHuJFY6PyClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTBwMkm5NUDPxE1? NWTBWlI3W0GQR1XS
8-MG-BA cell MWPHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NFHp[GRKdmirYnn0bY9vKG:oIHj1cYFvKDhvTVetRmEh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0zOy5yN{mzJO69VQ>? M2XDWHNCVkeHUh?=
A101D cell MmjLS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MXPJcohq[mm2aX;uJI9nKGi3bXHuJGEyODGGIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MT64O|A{PCEQvF2= M1uxWHNCVkeHUh?=
ACN cell NF\sWXFIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MnnFTY5pcWKrdHnvckBw\iCqdX3hckBCS05iY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1{MT60N|g4KM7:TR?= NHPkPZhUSU6JRWK=
AM-38 cell M2TPdWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NIXKbG5KdmirYnn0bY9vKG:oIHj1cYFvKEGPLUO4JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9O{4zPjN{NzFOwG0> NIrDc2pUSU6JRWK=
ATN-1 cell MV3Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M2q4OGlvcGmkaYTpc44hd2ZiaIXtZY4hSVSQLUGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yOE44PTV3IN88US=> MlL6V2FPT0WU
BB30-HNC cell NV\sSoxWT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NVPJSHBCUW6qaXLpeIlwdiCxZjDoeY1idiCEQkOwMWhPSyClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTJ{LkK1N|Ih|ryP NEnYToZUSU6JRWK=
BB49-HNC cell NEi0PJJIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MmnITY5pcWKrdHnvckBw\iCqdX3hckBDSjR7LVjOR{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVAvODB5OEmg{txO NEmxV2pUSU6JRWK=
human BC-1 cell NX;M[|FKT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NFfZ[lVKdmirYnn0bY9vKG:oIHj1cYFvKEKFLUGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2zMlk4OTB5IN88US=> MnjMV2FPT0WU
BE-13 cell M{Xwc2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NH[wPHJKdmirYnn0bY9vKG:oIHj1cYFvKEKHLUGzJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NE4yPDB6Md88US=> NF3mc4NUSU6JRWK=
BL-70 cell MmW4S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? Mk\tTY5pcWKrdHnvckBw\iCqdX3hckBDVC15MDDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUOuOFA4ODNizszN NViwSlF5W0GQR1XS
BV-173 cell MYDHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NFzE[pVKdmirYnn0bY9vKG:oIHj1cYFvKEKYLUG3N{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVE5Njh6NUmg{txO M{Wy[nNCVkeHUh?=
Becker cell MXfHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NYP0SVg1UW6qaXLpeIlwdiCxZjDoeY1idiCEZXPr[ZIh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yOy57NUS1JO69VQ>? NGLOdlJUSU6JRWK=
CAL-148 cell NUW1O3V[T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NFrndJBKdmirYnn0bY9vKG:oIHj1cYFvKEODTD2xOFgh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0{PS54NUW3JO69VQ>? MlTzV2FPT0WU
TE-10 cell NVnJS4N6T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NVTzbYlIUW6qaXLpeIlwdiCxZjDoeY1idiCWRT2xNEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIzNjh2MkOg{txO NV7RdWYxW0GQR1XS
TE-12 cell M1PRfGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NI\zcphKdmirYnn0bY9vKG:oIHj1cYFvKFSHLUGyJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9N|IvPDFzNDFOwG0> M2nnenNCVkeHUh?=
TE-8 cell MmjiS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MkG4TY5pcWKrdHnvckBw\iCqdX3hckBVTS16IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MUGuOlA5QSEQvF2= Mo\yV2FPT0WU
TE-9 cell M2DSVmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NHPTdmhKdmirYnn0bY9vKG:oIHj1cYFvKFSHLUmgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2zOk43OzhzIN88US=> MmXkV2FPT0WU
TGW cell NWS0S4JGT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M4q3O2lvcGmkaYTpc44hd2ZiaIXtZY4hXEeZIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MkOuN|U4PyEQvF2= NGn2O4xUSU6JRWK=
UACC-257 cell NUDrWo5oT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M3fLV2lvcGmkaYTpc44hd2ZiaIXtZY4hXUGFQz2yOVch[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF05NjdyNkK1JO69VQ>? MXnTRW5ITVJ?
WSU-NHL cell MWrHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NIrRcoNKdmirYnn0bY9vKG:oIHj1cYFvKFeVVT3OTGwh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0zPy5zOUC3JO69VQ>? NVGwcWRMW0GQR1XS
no-10 cell Ml3ZS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NGfme|lKdmirYnn0bY9vKG:oIHj1cYFvKG6xLUGwJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NE43Pjh2NjFOwG0> M1;JV3NCVkeHUh?=
no-11 cell MnjTS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NG\LbGZKdmirYnn0bY9vKG:oIHj1cYFvKG6xLUGxJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9OFcvODJ4MzFOwG0> NFTHeFJUSU6JRWK=
CAS-1 cell M2XZVmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MXvJcohq[mm2aX;uJI9nKGi3bXHuJGNCWy1zIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MD64OFch|ryP M4XBOHNCVkeHUh?=
CCRF-CEM cell MVXHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NIjkTlRKdmirYnn0bY9vKG:oIHj1cYFvKEOFUl[tR2VOKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:QC54NUO5NkDPxE1? M1LGdnNCVkeHUh?=
CMK cell M1myVGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MWDJcohq[mm2aX;uJI9nKGi3bXHuJGNOUyClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTFwMEGzNlMh|ryP NH25UWhUSU6JRWK=
COLO-829 cell MVLHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M3G0[mlvcGmkaYTpc44hd2ZiaIXtZY4hS0:OTz24Nlkh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0{NjJ2MkK2JO69VQ>? NVfNZZVVW0GQR1XS
COR-L279 cell NG\RXZJIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M2rJVGlvcGmkaYTpc44hd2ZiaIXtZY4hS0:ULVyyO|kh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0zNjB5M{ig{txO M{jFSXNCVkeHUh?=
CP66-MEL cell MX7Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NIfse5hKdmirYnn0bY9vKG:oIHj1cYFvKEOSNk[tUWVNKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OzZwNUS5O{DPxE1? M13oeXNCVkeHUh?=
CRO-AP2 cell MoLTS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NYrTT2FvUW6qaXLpeIlwdiCxZjDoeY1idiCFUl:tRXAzKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:Oi5|NkC4PEDPxE1? MXPTRW5ITVJ?
CTV-1 cell MUPHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NHXBNW5KdmirYnn0bY9vKG:oIHj1cYFvKEOWVj2xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NlMvQTF2NTFOwG0> NHLBNnBUSU6JRWK=
Calu-6 cell NFuzUZpIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M1qx[GlvcGmkaYTpc44hd2ZiaIXtZY4hS2GudT22JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9OFcvPTh4IN88US=> M4ryNnNCVkeHUh?=
D-247MG cell NHfmVHpIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M37KVWlvcGmkaYTpc44hd2ZiaIXtZY4hTC1{NEfNS{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVAvPjJ6MUSg{txO M{DlOHNCVkeHUh?=
D-263MG cell MVTHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MVHJcohq[mm2aX;uJI9nKGi3bXHuJGQuOjZ|TVegZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2wMlA5PTB7IN88US=> M{jWUXNCVkeHUh?=
D-336MG cell MWrHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NXrpXVZVUW6qaXLpeIlwdiCxZjDoeY1idiCGLUOzOm1IKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OC54Mki1OEDPxE1? M4jrPXNCVkeHUh?=
D-392MG cell NXLWc|VbT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MVHJcohq[mm2aX;uJI9nKGi3bXHuJGQuOzl{TVegZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlQ{ODN7IN88US=> NWjYbYRFW0GQR1XS
D-502MG cell MnXWS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M4TKZWlvcGmkaYTpc44hd2ZiaIXtZY4hTC13MELNS{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVgvPTN2OUKg{txO NID3dY5USU6JRWK=
D-542MG cell NX\0N2hUT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NHLXcJZKdmirYnn0bY9vKG:oIHj1cYFvKERvNUSyUWch[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yOi5|MUWyJO69VQ>? NV\0cZVJW0GQR1XS
DB cell MV3Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NIfpSlZKdmirYnn0bY9vKG:oIHj1cYFvKESEIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;NEeuNVQyPyEQvF2= Mn;LV2FPT0WU
DEL cell M3[4V2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M4\1c2lvcGmkaYTpc44hd2ZiaIXtZY4hTEWOIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Nz6wNVg6QCEQvF2= NITrcnpUSU6JRWK=
DMS-114 cell MmPvS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MYTJcohq[mm2aX;uJI9nKGi3bXHuJGROWy1zMUSgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME20PU45PDZ6IN88US=> M4LpZ3NCVkeHUh?=
DMS-153 cell MY\Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M2HvbWlvcGmkaYTpc44hd2ZiaIXtZY4hTE2VLUG1N{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVQzNjl7MkOg{txO NYnDPIwyW0GQR1XS
DOHH-2 cell M4f2bGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MlnHTY5pcWKrdHnvckBw\iCqdX3hckBFV0iKLUKgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME20MlIzPzZ2IN88US=> NGW1fIpUSU6JRWK=
DSH1 cell NF\4bZdIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MX3Jcohq[mm2aX;uJI9nKGi3bXHuJGRUUDFiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD16LkSzOlI{KM7:TR?= M2XiWXNCVkeHUh?=
Daudi cell M{TyOGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 Mon1TY5pcWKrdHnvckBw\iCqdX3hckBF[XWmaTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUKuNFk5ODJizszN MnfkV2FPT0WU
EC-GI-10 cell M3\qfWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MonNTY5pcWKrdHnvckBw\iCqdX3hckBGSy2JST2xNEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVQ1NjJ3OEmg{txO M373W3NCVkeHUh?=
ECC4 cell M{nR[Gdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MUfJcohq[mm2aX;uJI9nKGi3bXHuJGVESzRiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1|Mj6xPFk3KM7:TR?= M1WyPHNCVkeHUh?=
EM-2 cell MWLHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NGrUdmZKdmirYnn0bY9vKG:oIHj1cYFvKEWPLUKgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yMlQ2PTl2IN88US=> MXvTRW5ITVJ?
ES1 cell MkfpS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MmiyTY5pcWKrdHnvckBw\iCqdX3hckBGWzFiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD13LkW0NFg4KM7:TR?= M4L4[3NCVkeHUh?=
ES3 cell M2ize2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M3;kTmlvcGmkaYTpc44hd2ZiaIXtZY4hTVN|IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;NEKuOFczQSEQvF2= NYPqZ5k3W0GQR1XS
ES4 cell M{n6U2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NH7afHNKdmirYnn0bY9vKG:oIHj1cYFvKEWVNDDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUO1MlE6PSEQvF2= Mof2V2FPT0WU
ES6 cell M2\QT2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MUTJcohq[mm2aX;uJI9nKGi3bXHuJGVUPiClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTBwMkS3N|Mh|ryP NWLm[ZhJW0GQR1XS
ES7 cell NW\G[oloT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NIrNd4pKdmirYnn0bY9vKG:oIHj1cYFvKEWVNzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUWuNlMyOjRizszN NH64eGVUSU6JRWK=
ES8 cell MoDiS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? Ml;sTY5pcWKrdHnvckBw\iCqdX3hckBGWzhiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1yLkixPVI1KM7:TR?= Mn;aV2FPT0WU
EW-18 cell NYnDTopWT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NI\JOVBKdmirYnn0bY9vKG:oIHj1cYFvKEWZLUG4JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NVMvPjd3OTFOwG0> MVXTRW5ITVJ?
EW-22 cell NHzl[HdIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M3zBNWlvcGmkaYTpc44hd2ZiaIXtZY4hTVdvMkKgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME20O{44QTR5IN88US=> NEDZ[oJUSU6JRWK=
GCIY cell MVvHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NWjsV|d{UW6qaXLpeIlwdiCxZjDoeY1idiCJQ1nZJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9PU45ODN6OTFOwG0> MoXBV2FPT0WU
GDM-1 cell MoLxS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MnPNTY5pcWKrdHnvckBw\iCqdX3hckBITE1vMTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUiuN|kyQTZizszN NF64Z5BUSU6JRWK=
GI-1 cell NGLPdYFIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MU\Jcohq[mm2aX;uJI9nKGi3bXHuJGdKNTFiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1yLkCwOVI{KM7:TR?= M1vt[nNCVkeHUh?=
GI-ME-N cell NIj3emxIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M{\IOWlvcGmkaYTpc44hd2ZiaIXtZY4hT0lvTVWtUkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVAvODR7NUGg{txO NGPMfpZUSU6JRWK=
GR-ST cell NUjxO2RYT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M{HCO2lvcGmkaYTpc44hd2ZiaIXtZY4hT1JvU2SgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xN{44QTB{IN88US=> NVTodHkzW0GQR1XS
GT3TKB cell MmTJS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MnHTTY5pcWKrdHnvckBw\iCqdX3hckBIXDOWS1KgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlYxOzh7IN88US=> M1H0d3NCVkeHUh?=
HAL-01 cell NHjLZYhIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NYjL[JpMUW6qaXLpeIlwdiCxZjDoeY1idiCKQVytNFEh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF03NjZ7N{GyJO69VQ>? MmjUV2FPT0WU
HCC1599 cell Mof1S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NUHB[ZQ{UW6qaXLpeIlwdiCxZjDoeY1idiCKQ1OxOVk6KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OzdwNkCxNUDPxE1? NXXjbY03W0GQR1XS
HCC2218 cell NYT1TWdNT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M3nTOWlvcGmkaYTpc44hd2ZiaIXtZY4hUEOFMkKxPEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVE{NjN6M{Sg{txO NWHFb|dPW0GQR1XS
HD-MY-Z cell MXzHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NXnPU4R7UW6qaXLpeIlwdiCxZjDoeY1idiCKRD3NXU1bKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OjVwMkG0OkDPxE1? M4ezT3NCVkeHUh?=
HL-60 cell NVXy[5RET3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M4\ZSWlvcGmkaYTpc44hd2ZiaIXtZY4hUExvNkCgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xNk4zOTF2IN88US=> Mom2V2FPT0WU
HOP-62 cell NGjtPW1Iem:5dHigbY5pcWKrdHnvckBie3OjeR?= MoTpTY5pcWKrdHnvckBw\iCqdX3hckBJV1BvNkKgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yN{46PTJ5IN88US=> M2\POnNCVkeHUh?=
HT cell Ml;qS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MY\Jcohq[mm2aX;uJI9nKGi3bXHuJGhVKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:PC52NEOyNUDPxE1? NEfHU49USU6JRWK=
HT-144 cell MVrHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M2L1eGlvcGmkaYTpc44hd2ZiaIXtZY4hUFRvMUS0JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9OE46ODZ6NjFOwG0> NGDsPWlUSU6JRWK=
HUTU-80 cell NHHqSYVIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NFnJSlVKdmirYnn0bY9vKG:oIHj1cYFvKEiXVGWtPFAh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0{Njd6OUi2JO69VQ>? M{DwbXNCVkeHUh?=
IST-MEL1 cell MYnHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NH6ycVJKdmirYnn0bY9vKG:oIHj1cYFvKEmVVD3NSWwyKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OzJwOUC4OkDPxE1? NUjqfJRkW0GQR1XS
IST-SL1 cell M2jIbmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M3XOc2lvcGmkaYTpc44hd2ZiaIXtZY4hUVOWLWPMNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIvOTdyN{mg{txO NHjjZXhUSU6JRWK=
IST-SL2 cell NXS3UnZzT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NH;TcnlKdmirYnn0bY9vKG:oIHj1cYFvKEmVVD3TUFIh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0{NjJ4NkC4JO69VQ>? MknaV2FPT0WU
K052 cell MX7Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MnzZTY5pcWKrdHnvckBw\iCqdX3hckBMODV{IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MD63OVMxOSEQvF2= MXTTRW5ITVJ?
K5 cell NEHsV5FIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MVTJcohq[mm2aX;uJI9nKGi3bXHuJGs2KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OzNwNUmxOUDPxE1? NHXhOodUSU6JRWK=
KALS-1 cell M1HN[Gdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NXnwXI1pUW6qaXLpeIlwdiCxZjDoeY1idiCNQVzTMVEh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0zQS5|OU[5JO69VQ>? M3TGNnNCVkeHUh?=
KARPAS-422 cell M2m0SWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NIrmfXpKdmirYnn0bY9vKG:oIHj1cYFvKEuDUmDBV{01OjJiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD12Mj65NVQzKM7:TR?= MYnTRW5ITVJ?
KARPAS-45 cell NEjsdI1Iem:5dHigbY5pcWKrdHnvckBie3OjeR?= MljxTY5pcWKrdHnvckBw\iCqdX3hckBMSVKSQWOtOFUh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF01NjFzMkS3JO69VQ>? NV36UYRvW0GQR1XS
KE-37 cell NHH2[4tIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MUjJcohq[mm2aX;uJI9nKGi3bXHuJGtGNTN5IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;OT64N|Uh|ryP M4TaN3NCVkeHUh?=
KG-1 cell MVPHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MVTJcohq[mm2aX;uJI9nKGi3bXHuJGtINTFiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1{Mz65O|U4KM7:TR?= M3HDXHNCVkeHUh?=
KGN cell MVvHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? Mm\aTY5pcWKrdHnvckBw\iCqdX3hckBMT05iY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1yLkW2O|QzKM7:TR?= M1HnZXNCVkeHUh?=
KM12 cell NGfE[4VIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M3PPfmlvcGmkaYTpc44hd2ZiaIXtZY4hU01zMjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUOuOVI6PjRizszN MVzTRW5ITVJ?
KMOE-2 cell MVrHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? Mnj3TY5pcWKrdHnvckBw\iCqdX3hckBMVU:HLUKgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2zNE41PTR7IN88US=> M1\EUHNCVkeHUh?=
KNS-42 cell NVf2TmEyT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MnPNTY5pcWKrdHnvckBw\iCqdX3hckBMVlNvNEKgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME24MlgyQTF3IN88US=> NVj0TZhVW0GQR1XS
KNS-81-FD cell NGHKcmpIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M1K2NmlvcGmkaYTpc44hd2ZiaIXtZY4hU06VLUixMWZFKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OzdwNEK2JO69VQ>? NWDCXWF3W0GQR1XS
KS-1 cell MnfOS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MoWzTY5pcWKrdHnvckBw\iCqdX3hckBMWy1zIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MD6wNFQ3KM7:TR?= NI\mOmhUSU6JRWK=
KU812 cell NXfHe4h5T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MYPJcohq[mm2aX;uJI9nKGi3bXHuJGtWQDF{IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MkOuOFg1KM7:TR?= MX7TRW5ITVJ?
L-540 cell MWTHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MWXJcohq[mm2aX;uJI9nKGi3bXHuJGwuPTRyIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MkCuO|Q1PSEQvF2= NEPyTXJUSU6JRWK=
LAMA-84 cell M1PiTGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M1LFcWlvcGmkaYTpc44hd2ZiaIXtZY4hVEGPQT24OEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVE{NjZ5NEKg{txO NXzLbmFlW0GQR1XS
LB1047-RCC cell NYnyc4NlT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NV3VVoZCUW6qaXLpeIlwdiCxZjDoeY1idiCOQkGwOFcuWkOFIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MkiuN|g5OyEQvF2= NUe0VZlPW0GQR1XS
LB2241-RCC cell MmTpS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? Ml7RTY5pcWKrdHnvckBw\iCqdX3hckBNSjJ{NEGtVmNEKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OTBwNUWzOkDPxE1? MnflV2FPT0WU
LB2518-MEL cell NHLFWnRIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MnO4TY5pcWKrdHnvckBw\iCqdX3hckBNSjJ3MUitUWVNKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OS55MUS5Ou69VQ>? M4DKTHNCVkeHUh?=
LB831-BLC cell MnLsS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MULJcohq[mm2aX;uJI9nKGi3bXHuJGxDQDNzLVLMR{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEyNjF5Mk[g{txO NFj2TYxUSU6JRWK=
LB996-RCC cell NY\nVlVDT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NVSyNW9xUW6qaXLpeIlwdiCxZjDoeY1idiCOQkm5Ok1TS0NiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1zMj63OFMyKM7:TR?= NXG3UGdMW0GQR1XS
LC4-1 cell NVvIXYFOT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NFjN[WdKdmirYnn0bY9vKG:oIHj1cYFvKEyFND2xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9N|IvQDN2MTFOwG0> MYPTRW5ITVJ?
LOUCY cell NF3WWYJIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M3S0WGlvcGmkaYTpc44hd2ZiaIXtZY4hVE:XQ2mgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlE2Ojd4IN88US=> NFuwWoFUSU6JRWK=
LOXIMVI cell M33JbGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MlWwTY5pcWKrdHnvckBw\iCqdX3hckBNV1iLTW\JJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9N|AvOjF{MjFOwG0> NYf3ZW82W0GQR1XS
LS-123 cell NFzLS4tIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MlnoTY5pcWKrdHnvckBw\iCqdX3hckBNWy1zMkOgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2zPU4zOjV6IN88US=> MXTTRW5ITVJ?
LU-134-A cell M3f2bWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MkXiTY5pcWKrdHnvckBw\iCqdX3hckBNXS1zM{StRUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVcvOTRyNkig{txO MlLtV2FPT0WU
LU-139 cell Mni3S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M2XkOGlvcGmkaYTpc44hd2ZiaIXtZY4hVFVvMUO5JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NlIvOjF6IN88US=> MW\TRW5ITVJ?
LXF-289 cell M4jWdWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MYnJcohq[mm2aX;uJI9nKGi3bXHuJGxZTi1{OEmgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xO{41OzVzzszN Mm\kV2FPT0WU
MC116 cell NYnjNog3T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M2TZfGlvcGmkaYTpc44hd2ZiaIXtZY4hVUNzMU[gZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME20OU4xQDRzIN88US=> NFnTUFVUSU6JRWK=
MDA-MB-134-VI cell MoLLS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NVTTPIpDUW6qaXLpeIlwdiCxZjDoeY1idiCPRFGtUWIuOTN2LW\JJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9N|kvOjR6NjFOwG0> MXPTRW5ITVJ?
MFH-ino cell MV3Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MVzJcohq[mm2aX;uJI9nKGi3bXHuJG1HUC2rbn:gZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2wMlY1Ozh|IN88US=> NVXo[FlSW0GQR1XS
MHH-NB-11 cell NYL3[5k5T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= Mn\0TY5pcWKrdHnvckBw\iCqdX3hckBOUEhvTlKtNVEh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0xNjB4Nkmg{txO MmDiV2FPT0WU
ML-2 cell NVm1ZWdJT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M4G1S2lvcGmkaYTpc44hd2ZiaIXtZY4hVUxvMjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUOuOFA{ODRizszN MoPVV2FPT0WU
MOLT-13 cell NVWyTINUT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NHTmeopKdmirYnn0bY9vKG:oIHj1cYFvKE2RTGStNVMh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF01NjR|NkWzJO69VQ>? M3vlUXNCVkeHUh?=
MOLT-16 cell NEL1ZZRIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NWDCTYl1UW6qaXLpeIlwdiCxZjDoeY1idiCPT1zUMVE3KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:PC5zMUG2N{DPxE1? MV;TRW5ITVJ?
MOLT-4 cell NWr4eo9MT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MXvJcohq[mm2aX;uJI9nKGi3bXHuJG1QVFRvNDDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUG0MlQyOjRizszN MV\TRW5ITVJ?
MPP-89 cell MXLHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MlTjTY5pcWKrdHnvckBw\iCqdX3hckBOWFBvOEmgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlI2QTJ{IN88US=> MkHWV2FPT0WU
MRK-nu-1 cell M3T0O2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MWDJcohq[mm2aX;uJI9nKGi3bXHuJG1TUy2wdT2xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NE42PzV5MjFOwG0> NILqNFdUSU6JRWK=
MSTO-211H cell M1PpNWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MnPYTY5pcWKrdHnvckBw\iCqdX3hckBOW1SRLUKxNWgh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yOi56Nkmg{txO NXPVWWpOW0GQR1XS
MV-4-11 cell NYDCbVZKT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M3LweGlvcGmkaYTpc44hd2ZiaIXtZY4hVVZvND2xNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVAvOTN7MUWg{txO NHzOb|VUSU6JRWK=
NALM-6 cell NEO2b25Iem:5dHigbY5pcWKrdHnvckBie3OjeR?= MVPJcohq[mm2aX;uJI9nKGi3bXHuJG5CVE1vNjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGuOVYyODlizszN NELDW3FUSU6JRWK=
NB1 cell MV\Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NUXCe2d5UW6qaXLpeIlwdiCxZjDoeY1idiCQQkGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2zMlg1OzZ7IN88US=> NF7zeZVUSU6JRWK=
NB10 cell MkLXS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MXvJcohq[mm2aX;uJI9nKGi3bXHuJG5DOTBiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1yLkGzPVE2KM7:TR?= NFnWTWVUSU6JRWK=
NB12 cell NHzN[mVIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NIPMdVVKdmirYnn0bY9vKG:oIHj1cYFvKE6EMUKgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xOk42PjV4IN88US=> M4TWO3NCVkeHUh?=
NB13 cell Mo[zS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MkjUTY5pcWKrdHnvckBw\iCqdX3hckBPSjF|IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Mj6zNVI4QCEQvF2= MXLTRW5ITVJ?
NB17 cell NYjOXIFyT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MonSTY5pcWKrdHnvckBw\iCqdX3hckBPSjF5IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Mz61PFA2OSEQvF2= MVHTRW5ITVJ?
NB6 cell NV:0bIJVT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MUTJcohq[mm2aX;uJI9nKGi3bXHuJG5DPiClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTBwNUmxNVQh|ryP M1zvUHNCVkeHUh?=
NCCIT cell NEHHeG9Iem:5dHigbY5pcWKrdHnvckBie3OjeR?= MYXJcohq[mm2aX;uJI9nKGi3bXHuJG5ES0mWIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;NEGuPFQ2OyEQvF2= NIrHc2VUSU6JRWK=
NCI-H1155 cell NIS1NWRIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NWmzUI9MUW6qaXLpeIlwdiCxZjDoeY1idiCQQ1mtTFEyPTViY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1zND6zOFA5KM7:TR?= MVHTRW5ITVJ?
NCI-H1304 cell NH;re4hIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M33uTWlvcGmkaYTpc44hd2ZiaIXtZY4hVkOLLVixN|A1KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OTFwOEm4NkDPxE1? NYD2PGpUW0GQR1XS
NCI-H1355 cell MX\Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MXLJcohq[mm2aX;uJI9nKGi3bXHuJG5EUS2KMUO1OUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVQvQTRzMTFOwG0> NHzHV29USU6JRWK=
NCI-H1395 cell NUPteXg3T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MU\Jcohq[mm2aX;uJI9nKGi3bXHuJG5EUS2KMUO5OUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIzNjh5OUWg{txO MX7TRW5ITVJ?
NCI-H1417 cell NYruT5F2T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NFfqO3dKdmirYnn0bY9vKG:oIHj1cYFvKE6FST3INVQyPyClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTVwNke1NlIh|ryP MXLTRW5ITVJ?
NCI-H1436 cell NEPGZZFIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NEPNepBKdmirYnn0bY9vKG:oIHj1cYFvKE6FST3INVQ{PiClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTNwOESxNFEh|ryP M4PDbHNCVkeHUh?=
NTERA-S-cl-D1 cell MX3Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M3fUWGlvcGmkaYTpc44hd2ZiaIXtZY4hVlSHUlGtV{1kdC2GMTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGyMlg6OzVizszN NEX6TnJUSU6JRWK=
JiyoyeP-2003 cell MWHHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NUPSSJdSUW6qaXLpeIlwdiCxZjDoeY1idiCMaYnvfYVRNTJyMEOgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2zOk43Ojh2IN88US=> NVj1dJVtW0GQR1XS

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In vivo Oral administration of GSK269962A produced a profound dose-dependent reduction of systemic blood pressure in spontaneously hypertensive rats. The reduction of blood pressure was acute and substantial. The maximal effect on blood pressure was observed approximately 2 h after oral gavages. The reduction of blood pressure was accompanied by an acute, dose-dependent increase in heart rate, presumably due to the activation of baroreflex mechanism[1]. ROCK inhibition with the use of GSK 269962 in the 10 mg/kg dose, in turn, triggered an increase in VV(voided volume), PVR(post-void residual), VT(volume threshold), VE(voiding efficiency), ICI(intercontraction interval), BC(bladder compliance), and VTNVC(volume threshold to elicit NVC). The inhibition of the ROCK pathway through GSK 269962 appeared to have no effect on either HR(heart rate), SBP(systolic blood pressure), MBP(systolic blood pressure), or DBP(diastolic blood pressure)[2]. NVC:nonvoiding contractions.

Protocol

Cell Research:[1]
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  • Cell lines: Human primary smooth muscle cells
  • Concentrations: 3 μM
  • Incubation Time: 150 min
  • Method: Human primary smooth muscle cells were serum-starved(cells were grown on coverslips, and at approximately 50% confluence, they were serum-starved overnight) and stimulated with AngII (100 nM) for 2 h. ROCK inhibitors (3 μM for SB-772077-B or GSK269962A) were added 30 min before AngII stimulation, and cells were fixed and stained with rhodamine phalloidin. Confocal images of actin stain were obtained.
    (Only for Reference)
Animal Research:[2]
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  • Animal Models: female Wistar rats
  • Formulation: saline
  • Dosages: 5 or 10 mg/kg
  • Administration: intra-arterially
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 100 mg/mL (164.72 mM)
Ethanol 6 mg/mL (9.88 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 607.06
Formula

C29H30N8O5.HCl

CAS No. 850664-21-0(free base)
Storage powder
Synonyms GSK269962A, GSK269962B

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

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Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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ROCK Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID