GSK269962A HCl

Catalog No.S7687 Synonyms: GSK269962B, GSK269962, GSK 269962

GSK269962A HCl Chemical Structure

Molecular Weight(MW): 607.06

GSK269962 is a selective ROCK(Rho-associated protein kinase) inhibitor with IC50 values of 1.6 and 4 nM for ROCK1 and ROCK2, respectively.

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Purity & Quality Control

Choose Selective ROCK Inhibitors

Biological Activity

Description GSK269962 is a selective ROCK(Rho-associated protein kinase) inhibitor with IC50 values of 1.6 and 4 nM for ROCK1 and ROCK2, respectively.
Targets
ROCK1 [1]
(Cell-free assay)
ROCK2 [1]
(Cell-free assay)
MSK1 [1]
(Cell-free assay)
RSK1 [1]
(Cell-free assay)
1.6 nM 4 nM 49 nM 132 nM
In vitro

GSK269962A completely abolished the actin stress fiber formation induced by angiotensin II in human smooth muscles. Such suppressive effect on actin fiber formation was observed beginning at around 1 μM GSK269962A. GSK269962A induced vasorelaxation in preconstricted rat aorta(tissue baths) with an IC50 of 35 nM. the relaxation induced by GSK269962A is reversible. GSK269962A suppressed IL-6 mRNA transcription and reduced LPS-induced IL-6 and TNF-α protein production in macrophages[1].

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
NCI-H1581 NWO4[pN6T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NXPob|NLUW6qaXLpeIlwdiCxZjDoeY1idiCQQ1mtTFE2QDFiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1zOD64OFc4KM7:TR?= MWPTRW5ITVJ?
NCI-H1694 NXfrV49oT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MnO0TY5pcWKrdHnvckBw\iCqdX3hckBPS0lvSEG2PVQh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0zPC56N{S5JO69VQ>? M4nTR3NCVkeHUh?=
NCI-H1963 M1To[Gdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NHPx[o5KdmirYnn0bY9vKG:oIHj1cYFvKE6FST3INVk3OyClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTFwMke4N|kh|ryP NVv2OZRVW0GQR1XS
NCI-H2081 NXe0OFJwT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NFTWWGJKdmirYnn0bY9vKG:oIHj1cYFvKE6FST3INlA5OSClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTN2Lk[wOFQh|ryP M1LDTnNCVkeHUh?=
NCI-H209 M3vLUWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MV;Jcohq[mm2aX;uJI9nKGi3bXHuJG5EUS2KMkC5JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NlIvPjJ5MjFOwG0> MVvTRW5ITVJ?
NCI-H2107 NGq5VYpIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MXnJcohq[mm2aX;uJI9nKGi3bXHuJG5EUS2KMkGwO{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVI2NjZ3NkGg{txO NWK1SpZZW0GQR1XS
NCI-H2126 NGDBdWJIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MmHrTY5pcWKrdHnvckBw\iCqdX3hckBPS0lvSEKxNlYh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF03NjVyNEK2JO69VQ>? MnW4V2FPT0WU
NCI-H2171 Mn[4S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NWrlc|FQUW6qaXLpeIlwdiCxZjDoeY1idiCQQ1mtTFIyPzFiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1yLkm1PVM4KM7:TR?= M{KzRXNCVkeHUh?=
NCI-H2227 M1WySWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NYXRVW0yUW6qaXLpeIlwdiCxZjDoeY1idiCQQ1mtTFIzOjdiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD15Lki4OlE3KM7:TR?= NIfKPIRUSU6JRWK=
NCI-H524 Mk[2S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M1fu[mlvcGmkaYTpc44hd2ZiaIXtZY4hVkOLLVi1NlQh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0zOi56N{[zJO69VQ>? MVXTRW5ITVJ?
NCI-H526 NFvld2NIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MVrJcohq[mm2aX;uJI9nKGi3bXHuJG5EUS2KNUK2JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NVgvPTR|MTFOwG0> MkDFV2FPT0WU
NCI-H720 NXvZXWRjT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NF\UTJRKdmirYnn0bY9vKG:oIHj1cYFvKE6FST3IO|IxKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:Oi52NUG2NUDPxE1? NYPnTXlOW0GQR1XS
NMC-G1 M4flOWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M4LWTGlvcGmkaYTpc44hd2ZiaIXtZY4hVk2FLVexJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NVUvODV5ODFOwG0> NXXubVVtW0GQR1XS
NOS-1 cell NWTHWYNST3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NI\ndJJKdmirYnn0bY9vKG:oIHj1cYFvKE6RUz2xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9OU45OjJ7NDFOwG0> NEj2VotUSU6JRWK=
OCI-AML2 cell NX;YW3BkT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NXLmVXV{UW6qaXLpeIlwdiCxZjDoeY1idiCRQ1mtRW1NOiClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTFyLkm0PVYh|ryP M2HQcnNCVkeHUh?=
OCUB-M cell NUfpb25{T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NVvOVG5yUW6qaXLpeIlwdiCxZjDoeY1idiCRQ2XCMW0h[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yPy5{MEGg{txO MY\TRW5ITVJ?
ONS-76 cell NF3IWWFIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MlLvTY5pcWKrdHnvckBw\iCqdX3hckBQVlNvN{[gZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xN{46OTlzIN88US=> NYXJfW9nW0GQR1XS
OS-RC-2 cell M1qwemdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NXPaS4xTUW6qaXLpeIlwdiCxZjDoeY1idiCRUz3SR{0zKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:PDZwMUm1JO69VQ>? NHHXPJZUSU6JRWK=
OVCAR-4 cell MXnHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NEfsTnBKdmirYnn0bY9vKG:oIHj1cYFvKE:YQ1HSMVQh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF05NjdzOEC4JO69VQ>? MkDLV2FPT0WU
P30-OHK cell NFq4XYFIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MnfuTY5pcWKrdHnvckBw\iCqdX3hckBROzBvT1jLJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9O{43Ojh5NzFOwG0> M4D2ZXNCVkeHUh?=
P30-OHK cell MlPLS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NWCxV5lZUW6qaXLpeIlwdiCxZjDoeY1idiCSRj2zPFIh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF04NjB2OUW0JO69VQ>? NHHwcodUSU6JRWK=
PSN1 cell NVzPd|dxT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M{jKcGlvcGmkaYTpc44hd2ZiaIXtZY4hWFOQMTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPU[uNlIyOjZizszN NYn2bo1LW0GQR1XS
QIMR-WIL cell M2DERWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MmLhTY5pcWKrdHnvckBw\iCqdX3hckBSUU2ULWfJUEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVAvPDlyMESg{txO MVXTRW5ITVJ?
RCC10RGB cell M1ezNWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MU\Jcohq[mm2aX;uJI9nKGi3bXHuJHJESzFyUlfCJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NVgvQTB|NjFOwG0> NUGw[od{W0GQR1XS
RKO cell M3jIS2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NFLCPFlKdmirYnn0bY9vKG:oIHj1cYFvKFKNTzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGwMlU3PjJizszN NUPxOpB3W0GQR1XS
RL95-2 cell MlTVS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MkfGTY5pcWKrdHnvckBw\iCqdX3hckBTVDl3LUKgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xNE43PyEQvF2= NGHyUW5USU6JRWK=
RPMI-6666 cell NFXEV3hIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M2\5cGlvcGmkaYTpc44hd2ZiaIXtZY4hWlCPST22OlY3KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OThwNUKzOkDPxE1? MYPTRW5ITVJ?
RPMI-8402 cell NVGyNpk5T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NEH4fnVKdmirYnn0bY9vKG:oIHj1cYFvKFKSTVmtPFQxOiClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTRwNUi1OkDPxE1? MkjiV2FPT0WU
RXF393 cell NYXDUY9JT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= Ml25TY5pcWKrdHnvckBw\iCqdX3hckBTYEZ|OUOgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2wMlM6OyEQvF2= NHPaWHRUSU6JRWK=
Ramos-2G6-4C10 cell NFruXFRIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MYrJcohq[mm2aX;uJI9nKGi3bXHuJHJidW:|LULHOk01SzFyIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MT6zOVch|ryP MVrTRW5ITVJ?
SCLC-21H cell MWPHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M{PrfGlvcGmkaYTpc44hd2ZiaIXtZY4hW0OOQz2yNWgh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF04NjZzMUS5JO69VQ>? NXfzOYZXW0GQR1XS
SF126 cell M4e3[Gdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NFnKS3BKdmirYnn0bY9vKG:oIHj1cYFvKFOIMUK2JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NVEvQDN{Md88US=> M{jzfXNCVkeHUh?=
SF268 cell NWnYeIlIT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M{LSPGlvcGmkaYTpc44hd2ZiaIXtZY4hW0Z{NkigZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME22MlI{OTh|IN88US=> NVnUepdNW0GQR1XS
SF539 cell NY\nPHU1T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= Mnr5TY5pcWKrdHnvckBw\iCqdX3hckBUTjV|OTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGuNlg3PjFizszN NYLBbVlHW0GQR1XS
SH-4 cell MXXHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M4i0SGlvcGmkaYTpc44hd2ZiaIXtZY4hW0hvNDDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUWuO|U2ODhizszN Mln1V2FPT0WU
SIG-M5 cell NIr6Z49Iem:5dHigbY5pcWKrdHnvckBie3OjeR?= MljCTY5pcWKrdHnvckBw\iCqdX3hckBUUUdvTUWgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xNU44OjV7IN88US=> NVjMeXl1W0GQR1XS
SJSA-1 cell MoroS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MnLwTY5pcWKrdHnvckBw\iCqdX3hckBUUlODLUGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlA1PTJ4IN88US=> M2LqTHNCVkeHUh?=
SK-LMS-1 cell NX3o[GFiT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MkXuTY5pcWKrdHnvckBw\iCqdX3hckBUUy2OTWOtNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVMzNjV7NkWg{txO NIWxUFNUSU6JRWK=
SK-MM-2 cell NUfR[YViT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NECxdlVKdmirYnn0bY9vKG:oIHj1cYFvKFONLV3NMVIh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF01Oi5|NEC1JO69VQ>? M1TNSnNCVkeHUh?=
SK-N-DZ cell NXnWfG5ET3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= Mo\yTY5pcWKrdHnvckBw\iCqdX3hckBUUy2QLVTaJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9PU41QDNzNDFOwG0> MVLTRW5ITVJ?
SK-NEP-1 cell MYTHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M3zYUWlvcGmkaYTpc44hd2ZiaIXtZY4hW0tvTlXQMVEh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yPy53NEW2JO69VQ>? MmfMV2FPT0WU
SK-PN-DW cell M{G1U2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MmnnTY5pcWKrdHnvckBw\iCqdX3hckBUUy2STj3EW{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVI1Njl5M{[g{txO NY\nUpJoW0GQR1XS
SNB75 cell NFLrUmtIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MnG2TY5pcWKrdHnvckBw\iCqdX3hckBUVkJ5NTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUiuNFc4OzdizszN MUDTRW5ITVJ?
SR cell NV76bZI5T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MVLJcohq[mm2aX;uJI9nKGi3bXHuJHNTKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OC5yMECxN|ch|ryP NVG0fVdYW0GQR1XS
SU-DHL-1 cell Ml\4S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MWDJcohq[mm2aX;uJI9nKGi3bXHuJHNWNUSKTD2xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NVIvPzN|NjFOwG0> MVLTRW5ITVJ?
SW684 cell M4HBbGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NWizWIMzUW6qaXLpeIlwdiCxZjDoeY1idiCVV{[4OEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVM6NjBzMTFOwG0> NE\3[nlUSU6JRWK=
SW872 cell NF:5[JhIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NHPUR2RKdmirYnn0bY9vKG:oIHj1cYFvKFOZOEeyJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NE45QDZ3NjFOwG0> MonWV2FPT0WU
SW962 cell NHHEToFIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M2\XW2lvcGmkaYTpc44hd2ZiaIXtZY4hW1d7NkKgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xNk44PTJzIN88US=> MVXTRW5ITVJ?
697 cell NF;zTXdIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M1jjW2lvcGmkaYTpc44hd2ZiaIXtZY4hPjl5IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MD6yPVkyKM7:TR?= MY\TRW5ITVJ?
8-MG-BA cell M1XUd2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M{nzT2lvcGmkaYTpc44hd2ZiaIXtZY4hQC2PRz3CRUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVI{NjB5OUOg{txO M{[3VnNCVkeHUh?=
A101D cell M13ZZ2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NF\BT|JKdmirYnn0bY9vKG:oIHj1cYFvKEFzMEHEJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU45PzB|NDFOwG0> NHXTbGtUSU6JRWK=
ACN cell MWHHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MVLJcohq[mm2aX;uJI9nKGi3bXHuJGFEViClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTJzLkSzPFch|ryP NXXRZpNUW0GQR1XS
AM-38 cell MnnqS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NVPzcWFZUW6qaXLpeIlwdiCxZjDoeY1idiCDTT2zPEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVcvOjZ|Mkeg{txO M{LlfXNCVkeHUh?=
ATN-1 cell M2LMVGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M2jW[2lvcGmkaYTpc44hd2ZiaIXtZY4hSVSQLUGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yOE44PTV3IN88US=> MVPTRW5ITVJ?
BB30-HNC cell MoLtS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NVLveplyUW6qaXLpeIlwdiCxZjDoeY1idiCEQkOwMWhPSyClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTJ{LkK1N|Ih|ryP MVXTRW5ITVJ?
BB49-HNC cell NGS4UJlIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MnfNTY5pcWKrdHnvckBw\iCqdX3hckBDSjR7LVjOR{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVAvODB5OEmg{txO M1jKNXNCVkeHUh?=
human BC-1 cell MlHKS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NWjNSIhDUW6qaXLpeIlwdiCxZjDoeY1idiCEQz2xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9N{46PzFyNzFOwG0> MUXTRW5ITVJ?
BE-13 cell M4TKZmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MkPXTY5pcWKrdHnvckBw\iCqdX3hckBDTS1zMzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUCuNVQxQDIQvF2= M{P4TnNCVkeHUh?=
BL-70 cell NXrJUXVKT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M1zGcGlvcGmkaYTpc44hd2ZiaIXtZY4hSkxvN{CgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2zMlQxPzB|IN88US=> NHL6[|ZUSU6JRWK=
BV-173 cell M173dWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NUjNOYFwUW6qaXLpeIlwdiCxZjDoeY1idiCEVj2xO|Mh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yQC56OEW5JO69VQ>? M4fK[nNCVkeHUh?=
Becker cell M2f2NWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MkiwTY5pcWKrdHnvckBw\iCqdX3hckBD\WOtZYKgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xN{46PTR3IN88US=> NHrUOVRUSU6JRWK=
CAL-148 cell MV\Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MXjJcohq[mm2aX;uJI9nKGi3bXHuJGNCVC1zNEigZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2zOU43PTV5IN88US=> Mm\2V2FPT0WU
TE-10 cell M4rwWWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NWn1c4JkUW6qaXLpeIlwdiCxZjDoeY1idiCWRT2xNEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIzNjh2MkOg{txO M3z3RXNCVkeHUh?=
TE-12 cell NFP0NpBIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NGjYNpdKdmirYnn0bY9vKG:oIHj1cYFvKFSHLUGyJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9N|IvPDFzNDFOwG0> NF;vPINUSU6JRWK=
TE-8 cell M3rCe2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NU\0UGtEUW6qaXLpeIlwdiCxZjDoeY1idiCWRT24JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NVEvPjB6OTFOwG0> MmrmV2FPT0WU
TE-9 cell NXG2eVJxT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NIP2eWVKdmirYnn0bY9vKG:oIHj1cYFvKFSHLUmgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2zOk43OzhzIN88US=> MnnBV2FPT0WU
TGW cell NIi2coFIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NEjZNmpKdmirYnn0bY9vKG:oIHj1cYFvKFSJVzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUKzMlM2PzdizszN MnjrV2FPT0WU
UACC-257 cell MXTHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NIXPXGhKdmirYnn0bY9vKG:oIHj1cYFvKFWDQ1OtNlU4KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:QC55ME[yOUDPxE1? M4jNcHNCVkeHUh?=
WSU-NHL cell NXW1TYx3T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M3vpUmlvcGmkaYTpc44hd2ZiaIXtZY4hX1OXLV7IUEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVI4NjF7MEeg{txO MmLEV2FPT0WU
no-10 cell NUHiWW1ST3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M4f4bGlvcGmkaYTpc44hd2ZiaIXtZY4hdm9vMUCgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2wMlY3QDR4IN88US=> MmHSV2FPT0WU
no-11 cell MWLHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NVv2UGFGUW6qaXLpeIlwdiCxZjDoeY1idiCwbz2xNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVQ4NjB{NkOg{txO NXztfJpLW0GQR1XS
CAS-1 cell M4fMO2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NI\5XFVKdmirYnn0bY9vKG:oIHj1cYFvKEODUz2xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NE45PDdizszN NGDhT5hUSU6JRWK=
CCRF-CEM cell NFq0dFBIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MnrmTY5pcWKrdHnvckBw\iCqdX3hckBES1KILVPFUUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVgvPjV|OUKg{txO MnXPV2FPT0WU
CMK cell M3PodWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M4LD[WlvcGmkaYTpc44hd2ZiaIXtZY4hS02NIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MT6wNVMzOyEQvF2= M3uyd3NCVkeHUh?=
COLO-829 cell NFrmOlZIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MoL2TY5pcWKrdHnvckBw\iCqdX3hckBEV0yRLUiyPUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVMvOjR{Mk[g{txO MnTYV2FPT0WU
COR-L279 cell MXfHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NGW5[IdKdmirYnn0bY9vKG:oIHj1cYFvKEORUj3MNlc6KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:Oi5yN{O4JO69VQ>? MXHTRW5ITVJ?
CP66-MEL cell NYrrSWp4T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MkTqTY5pcWKrdHnvckBw\iCqdX3hckBEWDZ4LV3FUEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVM3NjV2OUeg{txO NED3eFdUSU6JRWK=
CRO-AP2 cell M1S3UWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NULvb4JMUW6qaXLpeIlwdiCxZjDoeY1idiCFUl:tRXAzKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:Oi5|NkC4PEDPxE1? M2XYS3NCVkeHUh?=
CTV-1 cell MXvHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M2rB[mlvcGmkaYTpc44hd2ZiaIXtZY4hS1SYLUGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yN{46OTR3IN88US=> MVTTRW5ITVJ?
Calu-6 cell MVHHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MnvFTY5pcWKrdHnvckBw\iCqdX3hckBE[Wy3LU[gZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME20O{42QDZizszN M1ywTnNCVkeHUh?=
D-247MG cell NHvwcJBIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MWjJcohq[mm2aX;uJI9nKGi3bXHuJGQuOjR5TVegZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2wMlYzQDF2IN88US=> NEL1RVRUSU6JRWK=
D-263MG cell MVPHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MU\Jcohq[mm2aX;uJI9nKGi3bXHuJGQuOjZ|TVegZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2wMlA5PTB7IN88US=> M3G3UnNCVkeHUh?=
D-336MG cell MWPHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NX\3eINIUW6qaXLpeIlwdiCxZjDoeY1idiCGLUOzOm1IKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OC54Mki1OEDPxE1? MVTTRW5ITVJ?
D-392MG cell NFL3T4FIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MknaTY5pcWKrdHnvckBw\iCqdX3hckBFNTN7Ml3HJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU41OzB|OTFOwG0> NXLufnptW0GQR1XS
D-502MG cell MYXHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MUPJcohq[mm2aX;uJI9nKGi3bXHuJGQuPTB{TVegZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME24MlU{PDl{IN88US=> MmrtV2FPT0WU
D-542MG cell Mlm1S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NVLkNIVvUW6qaXLpeIlwdiCxZjDoeY1idiCGLUW0Nm1IKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OTJwM{G1NkDPxE1? MUPTRW5ITVJ?
DB cell M4juVmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MoWyTY5pcWKrdHnvckBw\iCqdX3hckBFSiClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTR5LkG0NVch|ryP NXy4NpluW0GQR1XS
DEL cell NX76c2VDT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NV7HbHA1UW6qaXLpeIlwdiCxZjDoeY1idiCGRVygZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME23MlAyQDl6IN88US=> MYHTRW5ITVJ?
DMS-114 cell NXzEVVQ2T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MVrJcohq[mm2aX;uJI9nKGi3bXHuJGROWy1zMUSgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME20PU45PDZ6IN88US=> M1;4XXNCVkeHUh?=
DMS-153 cell NEXqV2JIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MojnTY5pcWKrdHnvckBw\iCqdX3hckBFVVNvMUWzJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9OFIvQTl{MzFOwG0> M2TORnNCVkeHUh?=
DOHH-2 cell Mln4S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NYC5emZ{UW6qaXLpeIlwdiCxZjDoeY1idiCGT1jIMVIh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF01NjJ{N{[0JO69VQ>? Mn;wV2FPT0WU
DSH1 cell MnPIS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MU\Jcohq[mm2aX;uJI9nKGi3bXHuJGRUUDFiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD16LkSzOlI{KM7:TR?= MYnTRW5ITVJ?
Daudi cell Ml7oS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MYDJcohq[mm2aX;uJI9nKGi3bXHuJGRifWSrIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Mj6wPVgxOiEQvF2= MnXkV2FPT0WU
EC-GI-10 cell M2\FTGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M2HB[2lvcGmkaYTpc44hd2ZiaIXtZY4hTUNvR1mtNVAh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF01PC5{NUi5JO69VQ>? MonmV2FPT0WU
ECC4 cell M3zV[mdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MojnTY5pcWKrdHnvckBw\iCqdX3hckBGS0N2IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;M{KuNVg6PiEQvF2= NIm4dYFUSU6JRWK=
EM-2 cell MkmzS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MkmyTY5pcWKrdHnvckBw\iCqdX3hckBGVS1{IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Mj60OVU6PCEQvF2= MXHTRW5ITVJ?
ES1 cell MYDHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NUPN[lVOUW6qaXLpeIlwdiCxZjDoeY1idiCHU{GgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME21MlU1ODh5IN88US=> NYDiOZVzW0GQR1XS
ES3 cell NULz[mhsT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M2fxTGlvcGmkaYTpc44hd2ZiaIXtZY4hTVN|IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;NEKuOFczQSEQvF2= NFznN2RUSU6JRWK=
ES4 cell NVjiRZV4T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NX\pSmRFUW6qaXLpeIlwdiCxZjDoeY1idiCHU{SgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2zOU4yQTVizszN M3jyVHNCVkeHUh?=
ES6 cell NELrTopIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M4rEN2lvcGmkaYTpc44hd2ZiaIXtZY4hTVN4IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MD6yOFc{OyEQvF2= M{jY[3NCVkeHUh?=
ES7 cell M1PVV2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M2HSV2lvcGmkaYTpc44hd2ZiaIXtZY4hTVN5IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;NT6yN|EzPCEQvF2= NWfjO4hLW0GQR1XS
ES8 cell MljLS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MX\Jcohq[mm2aX;uJI9nKGi3bXHuJGVUQCClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTBwOEG5NlQh|ryP MlfkV2FPT0WU
EW-18 cell M4LRbWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NG\rSnVKdmirYnn0bY9vKG:oIHj1cYFvKEWZLUG4JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NVMvPjd3OTFOwG0> M2DnPXNCVkeHUh?=
EW-22 cell M1j4SGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MnfjTY5pcWKrdHnvckBw\iCqdX3hckBGXy1{MjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUS3Mlc6PDdizszN Mn[zV2FPT0WU
GCIY cell NWjWRnhbT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M2jVbWlvcGmkaYTpc44hd2ZiaIXtZY4hT0OLWTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUmuPFA{QDlizszN MmXmV2FPT0WU
GDM-1 cell MVPHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MXnJcohq[mm2aX;uJI9nKGi3bXHuJGdFVS1zIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;OD6zPVE6PiEQvF2= NFO5UYhUSU6JRWK=
GI-1 cell NFnv[GlIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NH3rUnlKdmirYnn0bY9vKG:oIHj1cYFvKEeLLUGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2wMlAxPTJ|IN88US=> Ml\oV2FPT0WU
GI-ME-N cell Mny4S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NWn1fVdVUW6qaXLpeIlwdiCxZjDoeY1idiCJST3NSU1PKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OC5yNEm1NUDPxE1? MkTSV2FPT0WU
GR-ST cell MX7Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MWTJcohq[mm2aX;uJI9nKGi3bXHuJGdTNVOWIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MUOuO|kxOiEQvF2= NHS2dmZUSU6JRWK=
GT3TKB cell MYHHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M1PTXGlvcGmkaYTpc44hd2ZiaIXtZY4hT1R|VFvCJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU43ODN6OTFOwG0> MUXTRW5ITVJ?
HAL-01 cell Mo\5S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M{TtWmlvcGmkaYTpc44hd2ZiaIXtZY4hUEGOLUCxJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Ok43QTdzMjFOwG0> MVvTRW5ITVJ?
HCC1599 cell NFLnc49Iem:5dHigbY5pcWKrdHnvckBie3OjeR?= MXTJcohq[mm2aX;uJI9nKGi3bXHuJGhESzF3OUmgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2zO{43ODFzIN88US=> NFLsSIRUSU6JRWK=
HCC2218 cell M3PwNGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M2fm[GlvcGmkaYTpc44hd2ZiaIXtZY4hUEOFMkKxPEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVE{NjN6M{Sg{txO M3r5Z3NCVkeHUh?=
HD-MY-Z cell M{jCeGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NXz0eWVRUW6qaXLpeIlwdiCxZjDoeY1idiCKRD3NXU1bKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OjVwMkG0OkDPxE1? NFXOOZVUSU6JRWK=
HL-60 cell M1TsT2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NE\0UpFKdmirYnn0bY9vKG:oIHj1cYFvKEiOLU[wJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NVIvOjFzNDFOwG0> NHnsVphUSU6JRWK=
HOP-62 cell MU\Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MXXJcohq[mm2aX;uJI9nKGi3bXHuJGhQWC14MjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUKzMlk2OjdizszN NXfpSo5xW0GQR1XS
HT cell MlP6S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NHTmXnhKdmirYnn0bY9vKG:oIHj1cYFvKEiWIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;ND60OFMzOSEQvF2= MX3TRW5ITVJ?
HT-144 cell M{jQc2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MWfJcohq[mm2aX;uJI9nKGi3bXHuJGhVNTF2NDDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUSuPVA3QDZizszN M{jOUnNCVkeHUh?=
HUTU-80 cell NEfjfJJIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MUTJcohq[mm2aX;uJI9nKGi3bXHuJGhWXFVvOECgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2zMlc5QTh4IN88US=> NUjrW25pW0GQR1XS
IST-MEL1 cell MUXHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MmPhTY5pcWKrdHnvckBw\iCqdX3hckBKW1RvTVXMNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVMzNjlyOE[g{txO NF7oTXNUSU6JRWK=
IST-SL1 cell M1;hSmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MYrJcohq[mm2aX;uJI9nKGi3bXHuJGlUXC2VTEGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yMlE4ODd7IN88US=> MULTRW5ITVJ?
IST-SL2 cell NGn4WJhIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MV;Jcohq[mm2aX;uJI9nKGi3bXHuJGlUXC2VTEKgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2zMlI3PjB6IN88US=> MXTTRW5ITVJ?
K052 cell NInHNFlIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NGLkUWJKdmirYnn0bY9vKG:oIHj1cYFvKEtyNUKgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2wMlc2OzBzIN88US=> MYPTRW5ITVJ?
K5 cell MXTHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NYDR[IFZUW6qaXLpeIlwdiCxZjDoeY1idiCNNTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUOzMlU6OTVizszN MlfCV2FPT0WU
KALS-1 cell NIPZboxIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MoHFTY5pcWKrdHnvckBw\iCqdX3hckBMSUyVLUGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yPU4{QTZ7IN88US=> MofqV2FPT0WU
KARPAS-422 cell MV3Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MkXHTY5pcWKrdHnvckBw\iCqdX3hckBMSVKSQWOtOFIzKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:PDJwOUG0NkDPxE1? NIr3WodUSU6JRWK=
KARPAS-45 cell M1zl[mdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NXKybJhXUW6qaXLpeIlwdiCxZjDoeY1idiCNQWLQRXMuPDViY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD12LkGxNlQ4KM7:TR?= MXjTRW5ITVJ?
KE-37 cell NUHD[XVLT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MnO0TY5pcWKrdHnvckBw\iCqdX3hckBMTS1|NzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUmuPFM2KM7:TR?= MXjTRW5ITVJ?
KG-1 cell M3vVTGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 Mnv4TY5pcWKrdHnvckBw\iCqdX3hckBMTy1zIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MkOuPVc2PyEQvF2= NHu3c3lUSU6JRWK=
KGN cell MWTHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NYjRPHlsUW6qaXLpeIlwdiCxZjDoeY1idiCNR16gZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2wMlU3PzR{IN88US=> NYO5cWx{W0GQR1XS
KM12 cell Mki4S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M4PKe2lvcGmkaYTpc44hd2ZiaIXtZY4hU01zMjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUOuOVI6PjRizszN MUfTRW5ITVJ?
KMOE-2 cell MYPHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NYf0XW1WUW6qaXLpeIlwdiCxZjDoeY1idiCNTV;FMVIh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0{OC52NUS5JO69VQ>? NV7vVZVsW0GQR1XS
KNS-42 cell MXrHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NWL4c2pwUW6qaXLpeIlwdiCxZjDoeY1idiCNTmOtOFIh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF05NjhzOUG1JO69VQ>? M{fobHNCVkeHUh?=
KNS-81-FD cell NIfzfIZIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M3[3dmlvcGmkaYTpc44hd2ZiaIXtZY4hU06VLUixMWZFKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OzdwNEK2JO69VQ>? M3\nV3NCVkeHUh?=
KS-1 cell NHrEdXFIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MXLJcohq[mm2aX;uJI9nKGi3bXHuJGtUNTFiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1yLkCwOFYh|ryP MVjTRW5ITVJ?
KU812 cell M{T1UWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NWn0VZNCUW6qaXLpeIlwdiCxZjDoeY1idiCNVUixNkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVI{NjR6NDFOwG0> MW\TRW5ITVJ?
L-540 cell NIToNG5Iem:5dHigbY5pcWKrdHnvckBie3OjeR?= NUPtNXNQUW6qaXLpeIlwdiCxZjDoeY1idiCOLUW0NEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIxNjd2NEWg{txO NHO3epJUSU6JRWK=
LAMA-84 cell NYHldXdOT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NVf6UW5lUW6qaXLpeIlwdiCxZjDoeY1idiCOQV3BMVg1KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OTNwNke0NkDPxE1? NVi3VFRYW0GQR1XS
LB1047-RCC cell MXPHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MljoTY5pcWKrdHnvckBw\iCqdX3hckBNSjFyNEetVmNEKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OjhwM{i4N{DPxE1? NYfpTFBDW0GQR1XS
LB2241-RCC cell MnXwS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MkWyTY5pcWKrdHnvckBw\iCqdX3hckBNSjJ{NEGtVmNEKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OTBwNUWzOkDPxE1? MWPTRW5ITVJ?
LB2518-MEL cell MoTQS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M3q2cGlvcGmkaYTpc44hd2ZiaIXtZY4hVEJ{NUG4MW1GVCClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTFwN{G0PVbPxE1? NXjTSGg{W0GQR1XS
LB831-BLC cell MomwS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MWHJcohq[mm2aX;uJI9nKGi3bXHuJGxDQDNzLVLMR{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEyNjF5Mk[g{txO NEHtNJZUSU6JRWK=
LB996-RCC cell NITEboxIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NX7JZ5FuUW6qaXLpeIlwdiCxZjDoeY1idiCOQkm5Ok1TS0NiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1zMj63OFMyKM7:TR?= MVzTRW5ITVJ?
LC4-1 cell NEnHUJlIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NF3FZlVKdmirYnn0bY9vKG:oIHj1cYFvKEyFND2xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9N|IvQDN2MTFOwG0> M1u5WnNCVkeHUh?=
LOUCY cell MXHHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NGHxWIVKdmirYnn0bY9vKG:oIHj1cYFvKEyRVVPZJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU4yPTJ5NjFOwG0> NHfQSm5USU6JRWK=
LOXIMVI cell Mlu2S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NEXUZpJKdmirYnn0bY9vKG:oIHj1cYFvKEyRWFnNWmkh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0{OC5{MUKyJO69VQ>? Mn\EV2FPT0WU
LS-123 cell M3nQemdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M1qwVWlvcGmkaYTpc44hd2ZiaIXtZY4hVFNvMUKzJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9N|kvOjJ3ODFOwG0> NWLzOlVGW0GQR1XS
LU-134-A cell M4PYO2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MmPMTY5pcWKrdHnvckBw\iCqdX3hckBNXS1zM{StRUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVcvOTRyNkig{txO MoC4V2FPT0WU
LU-139 cell MWjHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NXn2NYJpUW6qaXLpeIlwdiCxZjDoeY1idiCOVT2xN|kh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0zOi5{MUig{txO MXLTRW5ITVJ?
LXF-289 cell MXTHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MWrJcohq[mm2aX;uJI9nKGi3bXHuJGxZTi1{OEmgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xO{41OzVzzszN NFfTSVlUSU6JRWK=
MC116 cell MXnHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MkLlTY5pcWKrdHnvckBw\iCqdX3hckBOSzFzNjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUS1MlA5PDFizszN MVjTRW5ITVJ?
MDA-MB-134-VI cell NFjweJFIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NVHiephLUW6qaXLpeIlwdiCxZjDoeY1idiCPRFGtUWIuOTN2LW\JJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9N|kvOjR6NjFOwG0> MnniV2FPT0WU
MFH-ino cell NE\BfoRIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MoOxTY5pcWKrdHnvckBw\iCqdX3hckBOTkhvaX7vJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NE43PDN6MzFOwG0> MVLTRW5ITVJ?
MHH-NB-11 cell MXvHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NVrhfpBIUW6qaXLpeIlwdiCxZjDoeY1idiCPSFitUmIuOTFiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1yLkC2Olkh|ryP NUX4eXZiW0GQR1XS
ML-2 cell MkLBS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NFTiS5lKdmirYnn0bY9vKG:oIHj1cYFvKE2OLUKgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2zMlQxOzB2IN88US=> M17xU3NCVkeHUh?=
MOLT-13 cell MV3Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MUHJcohq[mm2aX;uJI9nKGi3bXHuJG1QVFRvMUOgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME20MlQ{PjV|IN88US=> NGH1OYFUSU6JRWK=
MOLT-16 cell NHfjdnVIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M2HtdGlvcGmkaYTpc44hd2ZiaIXtZY4hVU:OVD2xOkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVQvOTFzNkOg{txO NVTPbVRXW0GQR1XS
MOLT-4 cell NVzrfVJOT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MWjJcohq[mm2aX;uJI9nKGi3bXHuJG1QVFRvNDDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUG0MlQyOjRizszN NYXFOlhPW0GQR1XS
MPP-89 cell NYrZNIpGT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NWnROldjUW6qaXLpeIlwdiCxZjDoeY1idiCPUGCtPFkh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yNjJ3OUKyJO69VQ>? NUfxSoN2W0GQR1XS
MRK-nu-1 cell NVLMXY9MT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NEmz[WVKdmirYnn0bY9vKG:oIHj1cYFvKE2USz3ueU0yKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OC53N{W3NkDPxE1? NFrqd4VUSU6JRWK=
MSTO-211H cell MX3Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NVSyTnhoUW6qaXLpeIlwdiCxZjDoeY1idiCPU2TPMVIyOUhiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1zMj64Olkh|ryP MXHTRW5ITVJ?
MV-4-11 cell M1jFOmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NUjB[HE2UW6qaXLpeIlwdiCxZjDoeY1idiCPVj20MVEyKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OC5zM{mxOUDPxE1? MVXTRW5ITVJ?
NALM-6 cell MYjHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NHHNd5JKdmirYnn0bY9vKG:oIHj1cYFvKE6DTF2tOkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEvPTZzMEmg{txO M{XzWnNCVkeHUh?=
NB1 cell NGPyNZRIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M3vpT2lvcGmkaYTpc44hd2ZiaIXtZY4hVkJzIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Mz64OFM3QSEQvF2= NVfiXlBGW0GQR1XS
NB10 cell MV;Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NYDPS3NlUW6qaXLpeIlwdiCxZjDoeY1idiCQQkGwJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NE4yOzlzNTFOwG0> NY\5XnBUW0GQR1XS
NB12 cell NEDCSFBIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NYLIT4J5UW6qaXLpeIlwdiCxZjDoeY1idiCQQkGyJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NVYvPTZ3NjFOwG0> M{G4VHNCVkeHUh?=
NB13 cell M3TxeGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M1rhbGlvcGmkaYTpc44hd2ZiaIXtZY4hVkJzMzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUKuN|EzPzhizszN M1jodnNCVkeHUh?=
NB17 cell NX;5bmJYT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= Mn;MTY5pcWKrdHnvckBw\iCqdX3hckBPSjF5IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Mz61PFA2OSEQvF2= MojSV2FPT0WU
NB6 cell MnT0S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NWGwUml5UW6qaXLpeIlwdiCxZjDoeY1idiCQQk[gZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2wMlU6OTF2IN88US=> NX\rR5l{W0GQR1XS
NCCIT cell MUHHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NIjBdotKdmirYnn0bY9vKG:oIHj1cYFvKE6FQ1nUJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9OFEvQDR3MzFOwG0> M3uzSnNCVkeHUh?=
NCI-H1155 cell NF[3dG5Iem:5dHigbY5pcWKrdHnvckBie3OjeR?= M4PVXWlvcGmkaYTpc44hd2ZiaIXtZY4hVkOLLVixNVU2KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OTRwM{SwPEDPxE1? MlXzV2FPT0WU
NCI-H1304 cell M4\JUmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MkHyTY5pcWKrdHnvckBw\iCqdX3hckBPS0lvSEGzNFQh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yOS56OUiyJO69VQ>? NHT6bmxUSU6JRWK=
NCI-H1355 cell NHvJcnpIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M4f4fWlvcGmkaYTpc44hd2ZiaIXtZY4hVkOLLVixN|U2KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:PC57NEGxJO69VQ>? NH2zUJJUSU6JRWK=
NCI-H1395 cell MYnHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MU\Jcohq[mm2aX;uJI9nKGi3bXHuJG5EUS2KMUO5OUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIzNjh5OUWg{txO NGPwOWNUSU6JRWK=
NCI-H1417 cell MUDHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MkHPTY5pcWKrdHnvckBw\iCqdX3hckBPS0lvSEG0NVch[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF02NjZ5NUKyJO69VQ>? M{fsPXNCVkeHUh?=
NCI-H1436 cell NVLSOJZuT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M4r1e2lvcGmkaYTpc44hd2ZiaIXtZY4hVkOLLVixOFM3KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:Oy56NEGwNUDPxE1? NH;tZ2hUSU6JRWK=
NTERA-S-cl-D1 cell NUjrS3pUT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NX7W[3ZqUW6qaXLpeIlwdiCxZjDoeY1idiCQVFXSRU1UNWOuLVSxJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NVIvQDl|NTFOwG0> NGi0enhUSU6JRWK=
JiyoyeP-2003 cell MoD1S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NWn0bolPUW6qaXLpeIlwdiCxZjDoeY1idiCMaYnvfYVRNTJyMEOgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2zOk43Ojh2IN88US=> M3PuTnNCVkeHUh?=

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In vivo Oral administration of GSK269962A produced a profound dose-dependent reduction of systemic blood pressure in spontaneously hypertensive rats. The reduction of blood pressure was acute and substantial. The maximal effect on blood pressure was observed approximately 2 h after oral gavages. The reduction of blood pressure was accompanied by an acute, dose-dependent increase in heart rate, presumably due to the activation of baroreflex mechanism[1]. ROCK inhibition with the use of GSK 269962 in the 10 mg/kg dose, in turn, triggered an increase in VV(voided volume), PVR(post-void residual), VT(volume threshold), VE(voiding efficiency), ICI(intercontraction interval), BC(bladder compliance), and VTNVC(volume threshold to elicit NVC). The inhibition of the ROCK pathway through GSK 269962 appeared to have no effect on either HR(heart rate), SBP(systolic blood pressure), MBP(systolic blood pressure), or DBP(diastolic blood pressure)[2]. NVC:nonvoiding contractions.

Protocol

Cell Research:[1]
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  • Cell lines: Human primary smooth muscle cells
  • Concentrations: 3 μM
  • Incubation Time: 150 min
  • Method: Human primary smooth muscle cells were serum-starved(cells were grown on coverslips, and at approximately 50% confluence, they were serum-starved overnight) and stimulated with AngII (100 nM) for 2 h. ROCK inhibitors (3 μM for SB-772077-B or GSK269962A) were added 30 min before AngII stimulation, and cells were fixed and stained with rhodamine phalloidin. Confocal images of actin stain were obtained.
    (Only for Reference)
Animal Research:[2]
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  • Animal Models: female Wistar rats
  • Formulation: saline
  • Dosages: 5 or 10 mg/kg
  • Administration: intra-arterially
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 100 mg/mL (164.72 mM)
Ethanol 6 mg/mL (9.88 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 607.06
Formula

C29H30N8O5.HCl

CAS No. 850664-21-0(free base)
Storage powder
in solvent
Synonyms GSK269962B, GSK269962, GSK 269962

Bio Calculators

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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ROCK Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID