BX-795

Catalog No.S1274

BX-795 Chemical Structure

Molecular Weight(MW): 591.47

BX795 is a potent and specific PDK1 inhibitor with IC50 of 6 nM, 140- and 1600-fold more selective for PDK1 than PKA and PKC in cell-free assays, respectively. Meanwhile, in comparison to GSK3β more than 100-fold selectivity observed for PDK1.

Size Price Stock Quantity  
In DMSO USD 200 In stock
USD 150 In stock
USD 320 In stock
USD 570 In stock
USD 970 In stock

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3 Customer Reviews

  • Induction of basal p62 Ser403 phosphorylation in ULK1/2-deficient MEF was suppressed by BX-795, an inhibitor of TBK1. WT ( Ulk1 +/+/Ulk2 +/+) and Ulk1 -/- /Ulk2 -/-(KO) MEF were treated with NaCl/Pi (Con) or 10 uM BX-795 for 6 h, and subjected to immunoblotting with indicated antibodies.

    FEBS J 2014 281(17), 3816-27. BX-795 purchased from Selleck.

    Virology 2014 450-451, 182-95. BX-795 purchased from Selleck.

  • Western blot analysis of pPRAS40 (T246), pS6 (S240/S244), and pS6 (S235/S236) proteins in (A) HeyA8 cells and (B) SKOV3 cells treated with 3.33 μM or 10 μM inhibitors (BX795 or CCT128930) in three-dimensional cell culture for 24 hours. Ten percent fetal bovine serum was used in A and B.

    PLoS One, 2016, 11(5):e0155052. . BX-795 purchased from Selleck.

Purity & Quality Control

Choose Selective PDK Inhibitors

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Notes:

2. For more details, such as half maximal inhibitory concentrations (IC50s) and working concentrations of each inhibitor, please click on the link of the inhibitor of interest.
3. "+" indicates inhibitory effect. Increased inhibition is marked by a higher "+" designation.
4. Orange "√" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

Biological Activity

Description BX795 is a potent and specific PDK1 inhibitor with IC50 of 6 nM, 140- and 1600-fold more selective for PDK1 than PKA and PKC in cell-free assays, respectively. Meanwhile, in comparison to GSK3β more than 100-fold selectivity observed for PDK1.
Targets
TBK1/IKKɛ [2]
(Cell-free assay)
PDK-1 [1]
(Cell-free assay)
c-Kit [1]
(Cell-free assay)
CDK2/CyclinE [1]
(Cell-free assay)
Chk1 [1]
(Cell-free assay)
6 nM 320 nM 430 nM 510 nM
In vitro

BX-795 effectively blocks PDK1 activity in PC-3 cells, as shown by their ability to block phosphorylation of S6K1, Akt, PKCδ, and GSK3β. BX-795 potently inhibits tumor cell growth on plastic with IC50 of 1.6, 1.4, and 1.9 μM for MDA-468, HCT-116 and MiaPaca cells, respectively. In soft agar, BX-795 displays higher growth inhibition with IC50 of 0.72, and 0.25 μM for MDA-468, and PC-3 cells, respectively. [1] In addition, BX-795, as an inhibitor of the TBK1/IKKɛ, blocks TBK1- and IKKε-mediated activation of IRF3 and production of IFN-β. [2] In platelet physiological responses, BX795 produces inhibitory effect on 2-MeSADP-induced or collagen-induced aggregation, ATP secretion and thromboxane generation. [3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
human MV-4-11 cell M3\PfWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MXXJcohq[mm2aX;uJI9nKGi3bXHuJG1XNTRvMUGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2zOk45KG6P NUjBV5RzW0GQR1XS
KRX cells MYTGeY5kfGmxbjDhd5NigQ>? M1LaelchdWmwcx?= MYHJcohq[mm2aX;uJI9nKFOXTV:teIFo\2WmIGXMT|EhMHWwa37ve44hd3KrZ3nuLUBscW6jc3Wg[I9u[WmwIHX4dJJme3OnZDDpckBMWlhiY3XscJMhfXOrbnegX|MzWF1vZ3HtcYEuSVSSIHHu[EBugWWuaX6gZoF{cWNicILveIVqdiC|dXLzeJJifGViaX7jeYJifGWmIH\vdkA4KG2rboO= MnvxNlYzPzV4OEG=
human NKM-1 cell NIn1UmhIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MYrJcohq[mm2aX;uJI9nKGi3bXHuJG5MVS1zIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MD6zOlE6PCEQvF2= NITkUIZUSU6JRWK=
human P30-OHK cell NXHQTFhkT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MXnJcohq[mm2aX;uJI9nKGi3bXHuJHA{OC2RSFugZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSxiSVO1NF0xNjR7NkWg{txO NH;IV2pUSU6JRWK=
human YH-13 cell M364V2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MnixTY5pcWKrdHnvckBw\iCqdX3hckB[UC1zMzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUCuOlI5QDhizszN M3\ienNCVkeHUh?=
human LXF-289 cell Mnf6S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NW\IZZljUW6qaXLpeIlwdiCxZjDoeY1idiCOWF[tNlg6KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XlwIFnDOVA:OC54NU[5N{DPxE1? NInVTGhUSU6JRWK=
human BE-13 cell NWW2SFhXT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NVLpVlZ4UW6qaXLpeIlwdiCxZjDoeY1idiCERT2xN{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVAvPzB2N{eg{txO M2Kw[nNCVkeHUh?=
human RS4-11 cell MVrHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M3TuN2lvcGmkaYTpc44hd2ZiaIXtZY4hWlN2LUGxJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NE44OjV7NDFOwG0> NGO2XHlUSU6JRWK=
human A3-KAW cell MkTtS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NXTHSGtHUW6qaXLpeIlwdiCxZjDoeY1idiCDMz3LRXch[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0xNjd|MEW1JO69VQ>? MofXV2FPT0WU
human PA-1 cell NFHqXYhIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NX3hTFVjUW6qaXLpeIlwdiCxZjDoeY1idiCSQT2xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NE45ODR{MjFOwG0> MXrTRW5ITVJ?
human ES7 cell MWXHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MX;Jcohq[mm2aX;uJI9nKGi3bXHuJGVUPyClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTBwOEO1OlYh|ryP MUPTRW5ITVJ?
human ES8 cell NYHQTGhmT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NH:3U4pKdmirYnn0bY9vKG:oIHj1cYFvKEWVODDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUCuPFQ{OzZizszN MlTmV2FPT0WU
human SW982 cell MYHHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NVK2Sm9bUW6qaXLpeIlwdiCxZjDoeY1idiCVV{m4NkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVAvQTVzMkSg{txO NYXBUYU6W0GQR1XS
human VA-ES-BJ cell MnjoS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M3zsfGlvcGmkaYTpc44hd2ZiaIXtZY4hXkFvRWOtRmoh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0xNjl6NE[3JO69VQ>? NF;ITZVUSU6JRWK=
human 697 cell MljpS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MVHJcohq[mm2aX;uJI9nKGi3bXHuJFY6PyClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTFwMEG2NlMh|ryP MoXiV2FPT0WU
human MOLT-4 cell NETxNG9Iem:5dHigbY5pcWKrdHnvckBie3OjeR?= MkHTTY5pcWKrdHnvckBw\iCqdX3hckBOV0yWLUSgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlA{OjR2IN88US=> M3X5d3NCVkeHUh?=
human D-283MED cell MXHHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NUnCUVJwUW6qaXLpeIlwdiCxZjDoeY1idiCGLUK4N21GTCClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTFwMEO5OFgh|pyv Mn:yV2FPT0WU
human ALL-PO cell MlrGS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NEPlOFlKdmirYnn0bY9vKG:oIHj1cYFvKEGOTD3QU{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEvODZyN{Og{txO NY\ZeotnW0GQR1XS
human NB14 cell MULHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NHXt[41KdmirYnn0bY9vKG:oIHj1cYFvKE6EMUSgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlA3ODhzIN88US=> NEPwRodUSU6JRWK=
human NTERA-S-cl-D1 cell MmjpS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MoX5TY5pcWKrdHnvckBw\iCqdX3hckBPXEWUQT3TMYNtNURzIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MT6wO|c4PSEQvF2= NXfLVFRIW0GQR1XS
human BFTC-905 cell NUKzTI5HT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= Mn3ETY5pcWKrdHnvckBw\iCqdX3hckBDTlSFLUmwOUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEvODhzMEGg{txO MX\TRW5ITVJ?
human H4 cell Ml;zS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NHXvbFVKdmirYnn0bY9vKG:oIHj1cYFvKEh2IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MT6xNFIxOSEQvF2= NUfJW3RzW0GQR1XS
human CHP-212 cell M2nmRmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MnfuTY5pcWKrdHnvckBw\iCqdX3hckBEUFBvMkGyJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU4yPDB|NzFOwG0> NFnKbWlUSU6JRWK=
human A204 cell MVXHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MlrHTY5pcWKrdHnvckBw\iCqdX3hckBCOjB2IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MT6xOVQ3PyEQvF2= MYrTRW5ITVJ?
human NB69 cell NFvUTWpIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MXHJcohq[mm2aX;uJI9nKGi3bXHuJG5DPjliY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1zLkG1PFY2KM7:TR?= NW\WVZBCW0GQR1XS
human P12-ICHIKAWA cell NVjqZXVrT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= Mn3qTY5pcWKrdHnvckBw\iCqdX3hckBROTJvSVPITWtCX0FiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1zLkG4NVcyKM7:TR?= M3HKdXNCVkeHUh?=
human L-363 cell M4DHbWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MmK0TY5pcWKrdHnvckBw\iCqdX3hckBNNTN4MzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGuNVgyQTdizszN MnHpV2FPT0WU
human ES5 cell MoHiS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NYHPVWNsUW6qaXLpeIlwdiCxZjDoeY1idiCHU{WgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlE6OzV2IN88US=> M2\HUHNCVkeHUh?=
human CAL-51 cell NFj3OI1Iem:5dHigbY5pcWKrdHnvckBie3OjeR?= NH7Q[ZdKdmirYnn0bY9vKG:oIHj1cYFvKEODTD21NUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEvOjJzNU[g{txO NXiyN4lDW0GQR1XS
human NBsusSR cell NEDtfmdIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MUXJcohq[mm2aX;uJI9nKGi3bXHuJG5De3W|U2KgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlI1PTd6IN88US=> MlTBV2FPT0WU
human HOP-92 cell NETNNJZIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M2LSbGlvcGmkaYTpc44hd2ZiaIXtZY4hUE:SLUmyJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU4zPzJ7MzFOwG0> NYPKc4R7W0GQR1XS
human DU-4475 cell NHftdG9Iem:5dHigbY5pcWKrdHnvckBie3OjeR?= Ml\wTY5pcWKrdHnvckBw\iCqdX3hckBFXS12NEe1JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU4zQTJ2NTFOwG0> NYnmO2hLW0GQR1XS
human LB1047-RCC cell M3rvRWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NELyZY5KdmirYnn0bY9vKG:oIHj1cYFvKEyEMUC0O{1TS0NiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1zLkK5NlgyKM7:TR?= MX\TRW5ITVJ?
human D-566MG cell MWfHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M1rpdmlvcGmkaYTpc44hd2ZiaIXtZY4hTC13Nk\NS{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEvOzB2NEig{txO MmD3V2FPT0WU
human A375 cell Mn7xS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MXfJcohq[mm2aX;uJI9nKGi3bXHuJGE{PzViY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1zLkOwPFU5KM7:TR?= M1u1eXNCVkeHUh?=
human ATN-1 cell M{DMWmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NYiycmxIUW6qaXLpeIlwdiCxZjDoeY1idiCDVF6tNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEvOzdzOEWg{txO MXPTRW5ITVJ?
human M059J cell MkH0S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M33QUmlvcGmkaYTpc44hd2ZiaIXtZY4hVTB3OVqgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlM4PjV{IN88US=> MULTRW5ITVJ?
human HSC-3 cell Mn3JS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NWDkZZFSUW6qaXLpeIlwdiCxZjDoeY1idiCKU1OtN{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEvPDR{MEig{txO MX3TRW5ITVJ?
human DOHH-2 cell M3joZWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NHrId|JKdmirYnn0bY9vKG:oIHj1cYFvKESRSFitNkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEvPDV6MUSg{txO MUjTRW5ITVJ?
human G-402 cell MV\Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MoXyTY5pcWKrdHnvckBw\iCqdX3hckBINTRyMjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGuOFY2OjVizszN Mk\WV2FPT0WU
human LC-2-ad cell MlTOS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NYT2e21TUW6qaXLpeIlwdiCxZjDoeY1idiCOQz2yMYFlKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OS52N{GzNkDPxE1? NWC3WFBpW0GQR1XS
human LOXIMVI cell NUHBd45LT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MmqyTY5pcWKrdHnvckBw\iCqdX3hckBNV1iLTW\JJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU42ODV3MjFOwG0> NGf2NWtUSU6JRWK=
human DK-MG cell NW\jdnh[T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NIGzOJJKdmirYnn0bY9vKG:oIHj1cYFvKESNLV3HJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU42PzJ7ODFOwG0> M{PSUnNCVkeHUh?=
human HOS cell MWjHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? Mo\nTY5pcWKrdHnvckBw\iCqdX3hckBJV1NiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1zLkW3N|A6KM7:TR?= M{LuRXNCVkeHUh?=
human BHT-101 cell M3;ZU2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NVXic4w2UW6qaXLpeIlwdiCxZjDoeY1idiCESGStNVAyKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OS53N{i3O{DPxE1? NFvtXm9USU6JRWK=
human U-2-OS cell NWTvNJcyT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MVvJcohq[mm2aX;uJI9nKGi3bXHuJHUuOi2RUzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGuOVg5ODZizszN MXPTRW5ITVJ?
human D-423MG cell M1zrZWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MmnWTY5pcWKrdHnvckBw\iCqdX3hckBFNTR{M13HJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU43ODhyNjFOwG0> MoPkV2FPT0WU
human AN3-CA cell NHfqO4JIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NIDmZWtKdmirYnn0bY9vKG:oIHj1cYFvKEGQMz3DRUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEvPjN7OUGg{txO NV\V[5g{W0GQR1XS
human TE-11 cell M{f6NWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NUPPT25qUW6qaXLpeIlwdiCxZjDoeY1idiCWRT2xNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEvPjV{ODFOwG0> NILxUIxUSU6JRWK=
human SK-NEP-1 cell NWXre3pHT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NGrEdW9KdmirYnn0bY9vKG:oIHj1cYFvKFONLV7FVE0yKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OS54NUO3OkDPxE1? MoTuV2FPT0WU
human MG-63 cell NFj5fHZIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M1fIWWlvcGmkaYTpc44hd2ZiaIXtZY4hVUdvNkOgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlY5PTZ5IN88US=> MYnTRW5ITVJ?
human RH-1 cell M4nufmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MlPzTY5pcWKrdHnvckBw\iCqdX3hckBTUC1zIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MT63NFI4PCEQvF2= NGrvXI5USU6JRWK=
human MDA-MB-157 cell NXPpeZplT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NGPuR4xKdmirYnn0bY9vKG:oIHj1cYFvKE2GQT3NRk0yPTdiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1zLkexOlc1KM7:TR?= MUTTRW5ITVJ?
human A427 cell M3HmPGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NG\BdGJKdmirYnn0bY9vKG:oIHj1cYFvKEF2MkegZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlc{PTh7IN88US=> NVXrb5JDW0GQR1XS
human ES1 cell Mnq0S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NXXrRWFwUW6qaXLpeIlwdiCxZjDoeY1idiCHU{GgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlc2PDVzIN88US=> MlWzV2FPT0WU
human C32 cell M4m0fWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NG\lO4pKdmirYnn0bY9vKG:oIHj1cYFvKEN|MjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGuO|Y{QSEQvF2= NH7RWJNUSU6JRWK=
human LAMA-84 cell M2rXO2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NGHKdVJKdmirYnn0bY9vKG:oIHj1cYFvKEyDTVGtPFQh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yNjd4OEeyJO69VQ>? NV;1UphFW0GQR1XS
human YKG-1 cell MoDzS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MmfCTY5pcWKrdHnvckBw\iCqdX3hckB[U0dvMTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGuO|cyOjRizszN M4LHWHNCVkeHUh?=
human NCI-H1048 cell M4rDNGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 Mn3VTY5pcWKrdHnvckBw\iCqdX3hckBPS0lvSEGwOFgh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yNjd6NUC5JO69VQ>? M2Ha[XNCVkeHUh?=
human KS-1 cell NF3rOWNIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MUjJcohq[mm2aX;uJI9nKGi3bXHuJGtUNTFiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1zLkiyPVgh|ryP NV;VVmVlW0GQR1XS
human JVM-3 cell NUXXUZdrT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M3rIb2lvcGmkaYTpc44hd2ZiaIXtZY4hUl[PLUOgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlg3PDlzIN88US=> NFi5cXRUSU6JRWK=
human GI-ME-N cell MXTHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NYnwVppIUW6qaXLpeIlwdiCxZjDoeY1idiCJST3NSU1PKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OS56NkWzJO69VQ>? MYfTRW5ITVJ?
human GT3TKB cell NFjjeZlIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MXTJcohq[mm2aX;uJI9nKGi3bXHuJGdVO1SNQjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGuPFk3PDJizszN NGHHR|FUSU6JRWK=
human CHL-1 cell NG\hdZhIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NVjxN4JWUW6qaXLpeIlwdiCxZjDoeY1idiCFSFytNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEvQTJ|N{mg{txO NEnJ[21USU6JRWK=
human CHP-134 cell MXLHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MnrQTY5pcWKrdHnvckBw\iCqdX3hckBEUFBvMUO0JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU46PDR4NzFOwG0> M3;IdnNCVkeHUh?=
human 8-MG-BA cell M3TPfmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MXnJcohq[mm2aX;uJI9nKGi3bXHuJFguVUdvQlGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlk2PzR2IN88US=> NIjIW3lUSU6JRWK=
human HO-1-N-1 cell NHTi[mxIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MnvlTY5pcWKrdHnvckBw\iCqdX3hckBJVy1zLV6tNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEvQTdzMUeg{txO MnL4V2FPT0WU
human SW1088 cell MnXyS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NGjMcWVKdmirYnn0bY9vKG:oIHj1cYFvKFOZMUC4PEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEvQTl4N{Og{txO NUTx[o5{W0GQR1XS
human SW48 cell NXW2cXltT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NIjWN2FKdmirYnn0bY9vKG:oIHj1cYFvKFOZNEigZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yMlAzODZ5IN88US=> M1\Kc3NCVkeHUh?=
human VM-CUB-1 cell MVLHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NFz5fJpKdmirYnn0bY9vKG:oIHj1cYFvKF[PLVPVRk0yKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:Oi5yNEGxPUDPxE1? NX[wV2xlW0GQR1XS
human COLO-800 cell NYC1cZVXT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NWDuTHoyUW6qaXLpeIlwdiCxZjDoeY1idiCFT1zPMVgxOCClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTJwMEWxN|Yh|ryP MXnTRW5ITVJ?
human TI-73 cell M37WU2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NGnSc2hKdmirYnn0bY9vKG:oIHj1cYFvKFSLLUezJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Nk4yOTN7OTFOwG0> MnjVV2FPT0WU
human HN cell NGq2OFlIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NH\pW3VKdmirYnn0bY9vKG:oIHj1cYFvKEiQIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Mj6xNlE6QCEQvF2= NIfnemhUSU6JRWK=
human DB cell NVq2OXprT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M2G5S2lvcGmkaYTpc44hd2ZiaIXtZY4hTEJiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1{LkGyOlMyKM7:TR?= MWfTRW5ITVJ?
human Ca9-22 cell NGT6NYxIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M1jrWWlvcGmkaYTpc44hd2ZiaIXtZY4hS2F7LUKyJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Nk4yOjh2NzFOwG0> NGDN[2tUSU6JRWK=
human A549 cell MVnHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NUPBNlBlUW6qaXLpeIlwdiCxZjDoeY1idiCDNUS5JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Nk4yOzhyODFOwG0> M4LG[nNCVkeHUh?=
human KGN cell NVLTdHEzT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= Moi5TY5pcWKrdHnvckBw\iCqdX3hckBMT05iY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1{LkKyOVk2KM7:TR?= M4fON3NCVkeHUh?=
human BCPAP cell MnfaS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NUfZXJBRUW6qaXLpeIlwdiCxZjDoeY1idiCEQ2DBVEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIvOjNzNUig{txO M3vyUXNCVkeHUh?=
human Ramos-2G6-4C10 cell MYDHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MlTlTY5pcWKrdHnvckBw\iCqdX3hckBT[W2xcz2yS|YuPENzMDDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUKuNlM4PTlizszN MoXsV2FPT0WU
human OVCAR-5 cell NInrWoRIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M{PSN2lvcGmkaYTpc44hd2ZiaIXtZY4hV1[FQWKtOUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIvOjd5M{Sg{txO MoO3V2FPT0WU
human KG-1 cell NVjidXRZT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MoLKTY5pcWKrdHnvckBw\iCqdX3hckBMTy1zIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Mj6yO|c6OiEQvF2= M3vN[3NCVkeHUh?=
human CAKI-1 cell MU\Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NFLWRnlKdmirYnn0bY9vKG:oIHj1cYFvKEODS1mtNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIvOjhyNUig{txO NGTKWmNUSU6JRWK=
human QIMR-WIL cell MWLHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M{iwWWlvcGmkaYTpc44hd2ZiaIXtZY4hWUmPUj3XTWwh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0zNjJ6N{S0JO69VQ>? MnLTV2FPT0WU
human SW1710 cell MXrHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M{LldGlvcGmkaYTpc44hd2ZiaIXtZY4hW1dzN{GwJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Nk4zQTF2MjFOwG0> MVjTRW5ITVJ?
human SK-UT-1 cell MljoS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MVzJcohq[mm2aX;uJI9nKGi3bXHuJHNMNVWWLUGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yMlI6OzN7IN88US=> NHPoeFZUSU6JRWK=
human IST-SL1 cell NH\iWoRIem:5dHigbY5pcWKrdHnvckBie3OjeR?= Mn7iTY5pcWKrdHnvckBw\iCqdX3hckBKW1RvU1yxJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Nk4{OjF5NDFOwG0> NHfWeZRUSU6JRWK=
human SW962 cell M4HoZmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MoLOTY5pcWKrdHnvckBw\iCqdX3hckBUXzl4MjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUKuN|M4PTdizszN NGPPXVFUSU6JRWK=
human EM-2 cell NU\wOpVZT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MmT5TY5pcWKrdHnvckBw\iCqdX3hckBGVS1{IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Mj6zOVM{PyEQvF2= NXmyVHB1W0GQR1XS
human D-263MG cell MkXZS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NXzW[G42UW6qaXLpeIlwdiCxZjDoeY1idiCGLUK2N21IKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:Oi5|OEOyO{DPxE1? NHvjZpRUSU6JRWK=
human T98G cell MWLHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NWXnSYdLUW6qaXLpeIlwdiCxZjDoeY1idiCWOUjHJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Nk4{QDh3NzFOwG0> NWr3dVA3W0GQR1XS
human CTB-1 cell MX;Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NIXnb4RKdmirYnn0bY9vKG:oIHj1cYFvKEOWQj2xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Nk4{QTd4MTFOwG0> MYDTRW5ITVJ?
human Hs-578-T cell M1:zRmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 Mnr6TY5pcWKrdHnvckBw\iCqdX3hckBJey13N{itWEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIvPDF3OEeg{txO NFf2T2xUSU6JRWK=
human SF126 cell M1HJU2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MofMTY5pcWKrdHnvckBw\iCqdX3hckBUTjF{NjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUKuOFM3OjFizszN MoD6V2FPT0WU
human NCI-H460 cell MlrmS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NXrVO|VLUW6qaXLpeIlwdiCxZjDoeY1idiCQQ1mtTFQ3OCClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTJwNEO5OVUh|ryP MkP1V2FPT0WU
human NCI-H1755 cell M2rZNWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NEjKc4tKdmirYnn0bY9vKG:oIHj1cYFvKE6FST3INVc2PSClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTJwNUSwOFMh|ryP MXnTRW5ITVJ?
human HL-60 cell MmDDS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NITOe5dKdmirYnn0bY9vKG:oIHj1cYFvKEiOLU[wJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Nk42PDF3OTFOwG0> NWrpVJhtW0GQR1XS
human G-401 cell MmTIS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MW\Jcohq[mm2aX;uJI9nKGi3bXHuJGcuPDBzIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Mj61OlA6QSEQvF2= NXfKXJd3W0GQR1XS
human AGS cell M{D6emdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NHrMUZdKdmirYnn0bY9vKG:oIHj1cYFvKEGJUzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUKuOVYzPTdizszN NEDJWnVUSU6JRWK=
human HuO9 cell MWnHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MWLJcohq[mm2aX;uJI9nKGi3bXHuJGh2VzliY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1{LkW2OFU3KM7:TR?= NFrtO2tUSU6JRWK=
human MFE-280 cell NH\YXohIem:5dHigbY5pcWKrdHnvckBie3OjeR?= Mn\uTY5pcWKrdHnvckBw\iCqdX3hckBOTkVvMkiwJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Nk42PjZ6NjFOwG0> NEL5VZJUSU6JRWK=
human NCI-H292 cell M4nPfGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NWK3W|dzUW6qaXLpeIlwdiCxZjDoeY1idiCQQ1mtTFI6OiClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTJwNUe3NlIh|ryP Mo\IV2FPT0WU
human HuO-3N1 cell MWfHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MlzKTY5pcWKrdHnvckBw\iCqdX3hckBJfU9vM16xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Nk43ODNyNzFOwG0> M3qzV3NCVkeHUh?=
human ES3 cell M3S3Tmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M2jibWlvcGmkaYTpc44hd2ZiaIXtZY4hTVN|IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Mj62NlI5PSEQvF2= M4[0c3NCVkeHUh?=
human LB2241-RCC cell NIC5NnhIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NWDlOoxyUW6qaXLpeIlwdiCxZjDoeY1idiCOQkKyOFEuWkOFIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Mj62PVA4QSEQvF2= M1zPNHNCVkeHUh?=
human NCI-H1155 cell M3TYT2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M3TGN2lvcGmkaYTpc44hd2ZiaIXtZY4hVkOLLVixNVU2KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:Oi54OUSwOUDPxE1? NHjsTFZUSU6JRWK=
human SW872 cell MWfHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NEPVTJBKdmirYnn0bY9vKG:oIHj1cYFvKFOZOEeyJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Nk44ODZ5NjFOwG0> MUjTRW5ITVJ?
human MHH-ES-1 cell NUDsc|BmT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MXPJcohq[mm2aX;uJI9nKGi3bXHuJG1JUC2HUz2xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Nk44OjZ|MzFOwG0> NVzKb2RyW0GQR1XS
human KYSE-150 cell NGC5ZnRIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NEHrRWJKdmirYnn0bY9vKG:oIHj1cYFvKEu\U1WtNVUxKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:Oi55Mkm3JO69VQ>? NFfqV5ZUSU6JRWK=
human MC-IXC cell MoHZS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NV\oVXNDUW6qaXLpeIlwdiCxZjDoeY1idiCPQz3JXGMh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0zNjh7NUOg{txO MlXlV2FPT0WU
human HCC1187 cell MVLHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NIXBS4xKdmirYnn0bY9vKG:oIHj1cYFvKEiFQ{GxPFch[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0zNjh7Nke3JO69VQ>? MonlV2FPT0WU
human UMC-11 cell NGWyWFZIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MlXjTY5pcWKrdHnvckBw\iCqdX3hckBWVUNvMUGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yMlkxPDd5IN88US=> MYPTRW5ITVJ?
human NB5 cell NGTFbopIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MoTWTY5pcWKrdHnvckBw\iCqdX3hckBPSjViY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1{LkmzO|E2KM7:TR?= NFP2XFJUSU6JRWK=
human A2058 cell MljrS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MoDMTY5pcWKrdHnvckBw\iCqdX3hckBCOjB3ODDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUKuPVc5PDRizszN MX3TRW5ITVJ?
human Becker cell MoPDS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MULJcohq[mm2aX;uJI9nKGi3bXHuJGJm[2uncjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUOuNFEyOTJizszN NHXubGxUSU6JRWK=
human CAS-1 cell NUe2SGZUT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MXrJcohq[mm2aX;uJI9nKGi3bXHuJGNCWy1zIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Mz6wNVU3QSEQvF2= MoTBV2FPT0WU
human SW780 cell NH\ZV5ZIem:5dHigbY5pcWKrdHnvckBie3OjeR?= Mmj4TY5pcWKrdHnvckBw\iCqdX3hckBUXzd6MDDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUOuNlU3ODlizszN M3LJT3NCVkeHUh?=
human KM12 cell M{G4NWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NG\Hb|lKdmirYnn0bY9vKG:oIHj1cYFvKEuPMUKgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2zMlMxOTN{IN88US=> NYe2OpY1W0GQR1XS
human PC-3 cell NYriNndXT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MWjJcohq[mm2aX;uJI9nKGi3bXHuJHBENTNiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD12LkG3OFEyKM7:TR?= MofIV2FPT0WU
human A253 cell M4[1UWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M3jFVWlvcGmkaYTpc44hd2ZiaIXtZY4hSTJ3MzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUSuNVg5QTNizszN M3PyN3NCVkeHUh?=
human NB10 cell NWGzZ5hET3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M1PSZWlvcGmkaYTpc44hd2ZiaIXtZY4hVkJzMDDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUSuNlI4PzNizszN Mm\3V2FPT0WU
human A172 cell M3vu[Gdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M{jtZmlvcGmkaYTpc44hd2ZiaIXtZY4hSTF5MjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUSuOFQ2PyEQvF2= MWnTRW5ITVJ?
human A498 cell MYjHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NH[x[oxKdmirYnn0bY9vKG:oIHj1cYFvKEF2OUigZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME20MlU3Ozh|IN88US=> MnviV2FPT0WU
human SW1573 cell NGjiR4lIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NFLNZ5pKdmirYnn0bY9vKG:oIHj1cYFvKFOZMUW3N{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVYvQTB2OUGg{txO NGfGZ5ZUSU6JRWK=
human 5637 cell NFjwNYhIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NVHCVVhRUW6qaXLpeIlwdiCxZjDoeY1idiB3NkO3JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9PE4xPzlyNDFOwG0> NITEUlBUSU6JRWK=
human A388 cell NHTHOJBIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MlrDTY5pcWKrdHnvckBw\iCqdX3hckBCOzh6IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MkGuNVM6QCEQvF2= MnOxV2FPT0WU
human U251 cell M2XK[mdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MlLnTY5pcWKrdHnvckBw\iCqdX3hckBWOjVzIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MkiuNVE4PSEQvF2= M2OwZ3NCVkeHUh?=

... Click to View More Cell Line Experimental Data

Protocol

Kinase Assay:[1]
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Kinase assays:

PDK1 is assayed in a direct kinase assay and a coupled assay format measuring PDK1- and PtdIns-3,4-P2-mediated activation of AKT2. For the coupled assay, the final assay mixture (60 μL) contained: 15 mM MOPS, pH 7.2, 1 mg/mL bovine serum albumin, 18 mM β-glycerol phosphate, 0.7 mM dithiothreitol, 3 mM EGTA, 10 mM MgOAc, 7.5 μM ATP, 0.2 μCi of [γ-33P]ATP, 7.5 μM biotinylated peptide substrate (biotin-ARRRDGGGAQPFRPRAATF), 0.5 μL of PtdIns-3,4-P2-containing phospholipid vesicles, 60 pg of purified recombinant human PDK1, and 172 ng of purified recombinant human AKT2. After incubation for 2 h at room temperature, the biotin-labeled peptide is captured from 10 μl of the assay mixture on streptavidin-coated SPA beads, and product formation is measured by scintillation proximity in a Wallac MicroBeta counter. The product formed is proportional to the time of incubation and to the amount of PDK1 and inactive AKT2 added. PDK1 is added at suboptimal levels so that the assay could sensitively detect inhibitors of AKT2 activation as well as direct inhibitors of PDK1 or AKT2. To measure PDK1 activity directly, the final assay mixture (60 μL) contained 50 mM Tris-HCl, pH 7.5, 0.1 mM EGTA, 0.1 mM EDTA, 0.1% β-mercaptoethanol, 1 mg/mL bovine serum albumin, 10 mM MgOAc, 10 μM ATP, 0.2 μCi of [γ-33P]ATP, 7.5 μM substrate peptide (H2N-ARRRGVTTKTFCGT), and 60 ng of purified recombinant human PDK1. After 4 h at room temperature, we add 25 mM EDTA and spotted a portion of the reaction mixture on Whatman P81 phosphocellulose paper. The filter paper is washed three times with 0.75% phosphoric acid and once with acetone. After drying, the filter-bound labeled peptide is quantified using a Fuji phosphorimager.
Cell Research:[1]
+ Expand
  • Cell lines: MDA-468, PC-3, HCT-116 and MiaPaca cells
  • Concentrations: ~10 μM
  • Incubation Time: 72 hours
  • Method: Cells seeded at a low density (1,500–3,000 cells/well, 0.1 mL/well, 96-well plates) are incubated overnight. Compound treatments are made by adding 10 μL/well of the compound in 1% dimethyl sulfoxide and growth medium (final concentration of dimethyl sulfoxide, 0.1%), followed by brief shaking. Treated cells are incubated for 72 hours, and viability is measured by the addition of 10 μL of the metabolic dye WST-1. The WST-1 signal is read in a plate reader at 450 nm, and a no cell, or zero time cell, background is subtracted to calculate the net signal. Results are reported as the average ± S.E. of two or more replicates.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 100 mg/mL (169.07 mM)
Water <1 mg/mL
Ethanol <1 mg/mL
In vivo 30% PEG400+0.5% Tween80+5% propylene glycol 30 mg/mL

* 1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 591.47
Formula

C23H26IN7O2S

CAS No. 702675-74-9
Storage powder
in solvent
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

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PDK Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID