BX-795

Catalog No.S1274

BX-795 Chemical Structure

Molecular Weight(MW): 591.47

BX795 is a potent and specific PDK1 inhibitor with IC50 of 6 nM, 140- and 1600-fold more selective for PDK1 than PKA and PKC in cell-free assays, respectively. Meanwhile, in comparison to GSK3β more than 100-fold selectivity observed for PDK1.

Size Price Stock Quantity  
In DMSO USD 200 In stock
USD 150 In stock
USD 320 In stock
USD 570 In stock
USD 970 In stock
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3 Customer Reviews

  • Induction of basal p62 Ser403 phosphorylation in ULK1/2-deficient MEF was suppressed by BX-795, an inhibitor of TBK1. WT ( Ulk1 +/+/Ulk2 +/+) and Ulk1 -/- /Ulk2 -/-(KO) MEF were treated with NaCl/Pi (Con) or 10 uM BX-795 for 6 h, and subjected to immunoblotting with indicated antibodies.

    FEBS J 2014 281(17), 3816-27. BX-795 purchased from Selleck.

    Virology 2014 450-451, 182-95. BX-795 purchased from Selleck.

  • Western blot analysis of pPRAS40 (T246), pS6 (S240/S244), and pS6 (S235/S236) proteins in (A) HeyA8 cells and (B) SKOV3 cells treated with 3.33 μM or 10 μM inhibitors (BX795 or CCT128930) in three-dimensional cell culture for 24 hours. Ten percent fetal bovine serum was used in A and B.

    PLoS One, 2016, 11(5):e0155052. . BX-795 purchased from Selleck.

Purity & Quality Control

Choose Selective PDK Inhibitors

Biological Activity

Description BX795 is a potent and specific PDK1 inhibitor with IC50 of 6 nM, 140- and 1600-fold more selective for PDK1 than PKA and PKC in cell-free assays, respectively. Meanwhile, in comparison to GSK3β more than 100-fold selectivity observed for PDK1.
Targets
TBK1/IKKɛ [2]
(Cell-free assay)
PDK-1 [1]
(Cell-free assay)
c-Kit [1]
(Cell-free assay)
CDK2/CyclinE [1]
(Cell-free assay)
Chk1 [1]
(Cell-free assay)
6 nM 320 nM 430 nM 510 nM
In vitro

BX-795 effectively blocks PDK1 activity in PC-3 cells, as shown by their ability to block phosphorylation of S6K1, Akt, PKCδ, and GSK3β. BX-795 potently inhibits tumor cell growth on plastic with IC50 of 1.6, 1.4, and 1.9 μM for MDA-468, HCT-116 and MiaPaca cells, respectively. In soft agar, BX-795 displays higher growth inhibition with IC50 of 0.72, and 0.25 μM for MDA-468, and PC-3 cells, respectively. [1] In addition, BX-795, as an inhibitor of the TBK1/IKKɛ, blocks TBK1- and IKKε-mediated activation of IRF3 and production of IFN-β. [2] In platelet physiological responses, BX795 produces inhibitory effect on 2-MeSADP-induced or collagen-induced aggregation, ATP secretion and thromboxane generation. [3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
human MV-4-11 cell MnrNS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MmH0TY5pcWKrdHnvckBw\iCqdX3hckBOXi12LUGxJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9N|YvQCCwTR?= MleyV2FPT0WU
KRX cells MUTGeY5kfGmxbjDhd5NigQ>? MXu3JI1qdnN? NV\aeoVRUW6qaXLpeIlwdiCxZjDTWW1QNXSjZ3fl[EBWVEtzIDj1cotvd3ewIH;ybYdqdilia3nuZZNmKGSxbXHpckBmgHC{ZYPz[YQhcW5iS2LYJINmdGy|IIXzbY5oKFt|MmDdMYdidW2jLVHUVEBidmRibYnlcIlvKGKjc3njJJBzd3SnaX6gd5Vje3S{YYTlJIlv[3WkYYTl[EBnd3JiNzDtbY5{ NF:3R5ozPjJ5NU[4NS=>
human NKM-1 cell NHfidW5Iem:5dHigbY5pcWKrdHnvckBie3OjeR?= NWiybYJsUW6qaXLpeIlwdiCxZjDoeY1idiCQS12tNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVAvOzZzOUSg{txO M4e0UHNCVkeHUh?=
human P30-OHK cell NI\uSGNIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NHjZU3lKdmirYnn0bY9vKG:oIHj1cYFvKFB|MD3PTGsh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTygTWM2OD1yLkS5OlUh|ryP NXXmdWZMW0GQR1XS
human YH-13 cell NEHnXI1Iem:5dHigbY5pcWKrdHnvckBie3OjeR?= NF;6cHBKdmirYnn0bY9vKG:oIHj1cYFvKFmKLUGzJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NE43Ojh6ODFOwG0> MWPTRW5ITVJ?
human LXF-289 cell Ml;WS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NFi1enNKdmirYnn0bY9vKG:oIHj1cYFvKEy[Rj2yPFkh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigS5iSVO1NF0xNjZ3NkmzJO69VQ>? MlfsV2FPT0WU
human BE-13 cell NGrUWXVIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M1rSXmlvcGmkaYTpc44hd2ZiaIXtZY4hSkVvMUOgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2wMlcxPDd5IN88US=> M4XPWXNCVkeHUh?=
human RS4-11 cell NGDPXGxIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MX7Jcohq[mm2aX;uJI9nKGi3bXHuJHJUPC1zMTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUCuO|I2QTRizszN M3fvSXNCVkeHUh?=
human A3-KAW cell MY\Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M{O0TGlvcGmkaYTpc44hd2ZiaIXtZY4hSTNvS1HXJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NE44OzB3NTFOwG0> M{jXSnNCVkeHUh?=
human PA-1 cell MoTOS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M2nLOGlvcGmkaYTpc44hd2ZiaIXtZY4hWEFvMTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUCuPFA1OjJizszN M{WwZnNCVkeHUh?=
human ES7 cell MkLlS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? Mn3OTY5pcWKrdHnvckBw\iCqdX3hckBGWzdiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1yLkizOVY3KM7:TR?= NIXBSJVUSU6JRWK=
human ES8 cell MVvHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NFLsellKdmirYnn0bY9vKG:oIHj1cYFvKEWVODDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUCuPFQ{OzZizszN NHf0SWlUSU6JRWK=
human SW982 cell NGm1VWlIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MXXJcohq[mm2aX;uJI9nKGi3bXHuJHNYQTh{IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MD65OVEzPCEQvF2= MXTTRW5ITVJ?
human VA-ES-BJ cell NETZ[W9Iem:5dHigbY5pcWKrdHnvckBie3OjeR?= MV3Jcohq[mm2aX;uJI9nKGi3bXHuJHZCNUWVLVLKJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NE46QDR4NzFOwG0> MmDXV2FPT0WU
human 697 cell MoHDS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MlnzTY5pcWKrdHnvckBw\iCqdX3hckA3QTdiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1zLkCxOlI{KM7:TR?= NEnybnpUSU6JRWK=
human MOLT-4 cell MWTHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NUDr[YV{UW6qaXLpeIlwdiCxZjDoeY1idiCPT1zUMVQh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yNjB|MkS0JO69VQ>? NInjSlFUSU6JRWK=
human D-283MED cell MlHLS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NHHuN|dKdmirYnn0bY9vKG:oIHj1cYFvKERvMkizUWVFKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OS5yM{m0PEDPpG1? Moj2V2FPT0WU
human ALL-PO cell M1LwOWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M{\2NWlvcGmkaYTpc44hd2ZiaIXtZY4hSUyOLWDPJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU4xPjB5MzFOwG0> MnnjV2FPT0WU
human NB14 cell NWDifmgzT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M4rKUGlvcGmkaYTpc44hd2ZiaIXtZY4hVkJzNDDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGuNFYxQDFizszN M4nZWHNCVkeHUh?=
human NTERA-S-cl-D1 cell MV3Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MXzJcohq[mm2aX;uJI9nKGi3bXHuJG5VTVKDLWOtZ4wuTDFiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1zLkC3O|c2KM7:TR?= NHjlc5RUSU6JRWK=
human BFTC-905 cell NXnqTHhtT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NFzQOYRKdmirYnn0bY9vKG:oIHj1cYFvKEKIVFOtPVA2KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OS5yOEGwNUDPxE1? NUfPWYZoW0GQR1XS
human H4 cell MXLHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M1fZSmlvcGmkaYTpc44hd2ZiaIXtZY4hUDRiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1zLkGwNlAyKM7:TR?= Mm\FV2FPT0WU
human CHP-212 cell NYqyRmVkT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MUPJcohq[mm2aX;uJI9nKGi3bXHuJGNJWC1{MUKgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlE1ODN5IN88US=> MnPkV2FPT0WU
human A204 cell M2PWOGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NWjYVXh{UW6qaXLpeIlwdiCxZjDoeY1idiCDMkC0JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU4yPTR4NzFOwG0> NX33[ndpW0GQR1XS
human NB69 cell M13pZmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NHKzeVJKdmirYnn0bY9vKG:oIHj1cYFvKE6ENkmgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlE2QDZ3IN88US=> NWXHbZNYW0GQR1XS
human P12-ICHIKAWA cell Mke4S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NXrxeJJGUW6qaXLpeIlwdiCxZjDoeY1idiCSMUKtTWNJUUuDV1GgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlE5OTdzIN88US=> MYHTRW5ITVJ?
human L-363 cell NWLiPYJ5T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M1;wVmlvcGmkaYTpc44hd2ZiaIXtZY4hVC1|NkOgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlE5OTl5IN88US=> MXzTRW5ITVJ?
human ES5 cell M{H3Wmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MXLJcohq[mm2aX;uJI9nKGi3bXHuJGVUPSClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTFwMUmzOVQh|ryP MYfTRW5ITVJ?
human CAL-51 cell MXfHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NX\kcWhTUW6qaXLpeIlwdiCxZjDoeY1idiCFQVytOVEh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yNjJ{MUW2JO69VQ>? M2[5PHNCVkeHUh?=
human NBsusSR cell NFHqV|VIem:5dHigbY5pcWKrdHnvckBie3OjeR?= Mn[2TY5pcWKrdHnvckBw\iCqdX3hckBPSnO3c2PSJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU4zPDV5ODFOwG0> MmfiV2FPT0WU
human HOP-92 cell MlnUS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MX3Jcohq[mm2aX;uJI9nKGi3bXHuJGhQWC17MjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGuNlczQTNizszN MWXTRW5ITVJ?
human DU-4475 cell MVfHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MYLJcohq[mm2aX;uJI9nKGi3bXHuJGRWNTR2N{WgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlI6OjR3IN88US=> MWXTRW5ITVJ?
human LB1047-RCC cell NXu1bpNqT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NYm5bnRkUW6qaXLpeIlwdiCxZjDoeY1idiCOQkGwOFcuWkOFIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MT6yPVI5OSEQvF2= M4\2fHNCVkeHUh?=
human D-566MG cell MojBS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MWDJcohq[mm2aX;uJI9nKGi3bXHuJGQuPTZ4TVegZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlMxPDR6IN88US=> NHvyW2dUSU6JRWK=
human A375 cell NYCzNHQxT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MkjETY5pcWKrdHnvckBw\iCqdX3hckBCOzd3IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MT6zNFg2QCEQvF2= Mn\1V2FPT0WU
human ATN-1 cell MYXHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MUHJcohq[mm2aX;uJI9nKGi3bXHuJGFVVi1zIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MT6zO|E5PSEQvF2= Ml;MV2FPT0WU
human M059J cell MYrHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MYHJcohq[mm2aX;uJI9nKGi3bXHuJG0xPTmMIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MT6zO|Y2OiEQvF2= MkXUV2FPT0WU
human HSC-3 cell NH7B[JlIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MXHJcohq[mm2aX;uJI9nKGi3bXHuJGhUSy1|IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MT60OFIxQCEQvF2= M{nGUXNCVkeHUh?=
human DOHH-2 cell Mk\2S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NXf6fI9bUW6qaXLpeIlwdiCxZjDoeY1idiCGT1jIMVIh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yNjR3OEG0JO69VQ>? MnXWV2FPT0WU
human G-402 cell MUTHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NV3tWXBZUW6qaXLpeIlwdiCxZjDoeY1idiCJLUSwNkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEvPDZ3MkWg{txO MkezV2FPT0WU
human LC-2-ad cell NYL6dIxKT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NWP2[3hkUW6qaXLpeIlwdiCxZjDoeY1idiCOQz2yMYFlKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OS52N{GzNkDPxE1? M1H1SXNCVkeHUh?=
human LOXIMVI cell MkHhS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M3T2VWlvcGmkaYTpc44hd2ZiaIXtZY4hVE:[SV3WTUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEvPTB3NUKg{txO M2e4c3NCVkeHUh?=
human DK-MG cell M{HkXGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MYPJcohq[mm2aX;uJI9nKGi3bXHuJGRMNU2JIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MT61O|I6QCEQvF2= MUHTRW5ITVJ?
human HOS cell NF\hNJFIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NVPjSXB{UW6qaXLpeIlwdiCxZjDoeY1idiCKT2OgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlU4OzB7IN88US=> M4PlbnNCVkeHUh?=
human BHT-101 cell NV\YSlBuT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NULMR|R2UW6qaXLpeIlwdiCxZjDoeY1idiCESGStNVAyKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OS53N{i3O{DPxE1? MnfMV2FPT0WU
human U-2-OS cell MorDS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NHXReIpKdmirYnn0bY9vKG:oIHj1cYFvKFVvMj3PV{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEvPTh6ME[g{txO MXHTRW5ITVJ?
human D-423MG cell MVTHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M33HfWlvcGmkaYTpc44hd2ZiaIXtZY4hTC12MkPNS{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEvPjB6ME[g{txO MUDTRW5ITVJ?
human AN3-CA cell MWfHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MWfJcohq[mm2aX;uJI9nKGi3bXHuJGFPOy2FQTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGuOlM6QTFizszN MnTxV2FPT0WU
human TE-11 cell NWDDNFh[T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= Mm\JTY5pcWKrdHnvckBw\iCqdX3hckBVTS1zMTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGuOlUzQCEQvF2= MVrTRW5ITVJ?
human SK-NEP-1 cell NVy2UmNlT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NHzhRYZKdmirYnn0bY9vKG:oIHj1cYFvKFONLV7FVE0yKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OS54NUO3OkDPxE1? M1rHc3NCVkeHUh?=
human MG-63 cell MonzS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NVnneGM{UW6qaXLpeIlwdiCxZjDoeY1idiCPRz22N{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEvPjh3Nkeg{txO NH64UlBUSU6JRWK=
human RH-1 cell M2rTeWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MV7Jcohq[mm2aX;uJI9nKGi3bXHuJHJJNTFiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1zLkewNlc1KM7:TR?= M3XVOnNCVkeHUh?=
human MDA-MB-157 cell M1zLcGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NVXLcJpbUW6qaXLpeIlwdiCxZjDoeY1idiCPRFGtUWIuOTV5IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MT63NVY4PCEQvF2= MULTRW5ITVJ?
human A427 cell NHn6dI1Iem:5dHigbY5pcWKrdHnvckBie3OjeR?= MnS3TY5pcWKrdHnvckBw\iCqdX3hckBCPDJ5IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MT63N|U5QSEQvF2= MXfTRW5ITVJ?
human ES1 cell NHLmPWRIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NVrKVmNJUW6qaXLpeIlwdiCxZjDoeY1idiCHU{GgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlc2PDVzIN88US=> NF3wc|BUSU6JRWK=
human C32 cell NF[4W4RIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M3XF[WlvcGmkaYTpc44hd2ZiaIXtZY4hSzN{IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MT63OlM6KM7:TR?= NIL4eo5USU6JRWK=
human LAMA-84 cell NUTlUpBpT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MXHJcohq[mm2aX;uJI9nKGi3bXHuJGxCVUFvOESgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlc3QDd{IN88US=> NH3RXZNUSU6JRWK=
human YKG-1 cell MoW3S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MVfJcohq[mm2aX;uJI9nKGi3bXHuJHlMTy1zIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MT63O|EzPCEQvF2= NXnoeZVQW0GQR1XS
human NCI-H1048 cell MYPHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MX3Jcohq[mm2aX;uJI9nKGi3bXHuJG5EUS2KMUC0PEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEvPzh3MEmg{txO NVezU5NNW0GQR1XS
human KS-1 cell M3PCTWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MWjJcohq[mm2aX;uJI9nKGi3bXHuJGtUNTFiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1zLkiyPVgh|ryP MXzTRW5ITVJ?
human JVM-3 cell Ml6wS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NID5OXZKdmirYnn0bY9vKG:oIHj1cYFvKEqYTT2zJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU45PjR7MTFOwG0> M{noXXNCVkeHUh?=
human GI-ME-N cell MofmS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NY\VNJA2UW6qaXLpeIlwdiCxZjDoeY1idiCJST3NSU1PKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OS56NkWzJO69VQ>? NWO5WpZIW0GQR1XS
human GT3TKB cell M4HvWGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MXzJcohq[mm2aX;uJI9nKGi3bXHuJGdVO1SNQjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGuPFk3PDJizszN NHrtXJJUSU6JRWK=
human CHL-1 cell NFP1V|hIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NHnDN29KdmirYnn0bY9vKG:oIHj1cYFvKEOKTD2xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU46OjN5OTFOwG0> MlS1V2FPT0WU
human CHP-134 cell M3HIUmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NITaVGVKdmirYnn0bY9vKG:oIHj1cYFvKEOKUD2xN|Qh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yNjl2NE[3JO69VQ>? NWrafHJjW0GQR1XS
human 8-MG-BA cell NU[ydVhGT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NYe4bJpSUW6qaXLpeIlwdiCxZjDoeY1idiB6LV3HMWJCKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OS57NUe0OEDPxE1? M4XxU3NCVkeHUh?=
human HO-1-N-1 cell M2PWSmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NVXxdXplUW6qaXLpeIlwdiCxZjDoeY1idiCKTz2xMW4uOSClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTFwOUexNVch|ryP MX;TRW5ITVJ?
human SW1088 cell Mn\5S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MlroTY5pcWKrdHnvckBw\iCqdX3hckBUXzFyOEigZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlk6Pjd|IN88US=> NEPZfYtUSU6JRWK=
human SW48 cell MnfJS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M4S2WGlvcGmkaYTpc44hd2ZiaIXtZY4hW1d2ODDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUKuNFIxPjdizszN M3Lpb3NCVkeHUh?=
human VM-CUB-1 cell MlO4S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MorhTY5pcWKrdHnvckBw\iCqdX3hckBXVS2FVVKtNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIvODRzMUmg{txO M1nXVHNCVkeHUh?=
human COLO-800 cell Mn7nS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NXKxc5N4UW6qaXLpeIlwdiCxZjDoeY1idiCFT1zPMVgxOCClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTJwMEWxN|Yh|ryP Mn;PV2FPT0WU
human TI-73 cell M4nFS2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NF7GWYJKdmirYnn0bY9vKG:oIHj1cYFvKFSLLUezJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Nk4yOTN7OTFOwG0> M{n0XnNCVkeHUh?=
human HN cell NF\qZ|hIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M4PHTGlvcGmkaYTpc44hd2ZiaIXtZY4hUE5iY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1{LkGyNVk5KM7:TR?= M4jT[3NCVkeHUh?=
human DB cell Mn7GS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MXvJcohq[mm2aX;uJI9nKGi3bXHuJGRDKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:Oi5zMk[zNUDPxE1? NYPXO2NvW0GQR1XS
human Ca9-22 cell MX7Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? Mn3YTY5pcWKrdHnvckBw\iCqdX3hckBE[TlvMkKgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yMlEzQDR5IN88US=> MWLTRW5ITVJ?
human A549 cell NI\ubpVIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M{G0WWlvcGmkaYTpc44hd2ZiaIXtZY4hSTV2OTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUKuNVM5ODhizszN NVXQNG9CW0GQR1XS
human KGN cell MnHTS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MUfJcohq[mm2aX;uJI9nKGi3bXHuJGtIViClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTJwMkK1PVUh|ryP NEOwVVlUSU6JRWK=
human BCPAP cell MknqS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? Mmf6TY5pcWKrdHnvckBw\iCqdX3hckBDS1CDUDDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUKuNlMyPThizszN MnrvV2FPT0WU
human Ramos-2G6-4C10 cell MVfHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? Ml3RTY5pcWKrdHnvckBw\iCqdX3hckBT[W2xcz2yS|YuPENzMDDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUKuNlM4PTlizszN NF3OcpFUSU6JRWK=
human OVCAR-5 cell NE\zc45Iem:5dHigbY5pcWKrdHnvckBie3OjeR?= M1jmcGlvcGmkaYTpc44hd2ZiaIXtZY4hV1[FQWKtOUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIvOjd5M{Sg{txO M{L4cXNCVkeHUh?=
human KG-1 cell MUTHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NYHDVFh6UW6qaXLpeIlwdiCxZjDoeY1idiCNRz2xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Nk4zPzd7MjFOwG0> NWq5fZRHW0GQR1XS
human CAKI-1 cell NEf1NYdIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MV\Jcohq[mm2aX;uJI9nKGi3bXHuJGNCU0lvMTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUKuNlgxPThizszN MYDTRW5ITVJ?
human QIMR-WIL cell NFvBVFlIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NXPvPHBiUW6qaXLpeIlwdiCxZjDoeY1idiCTSV3SMXdKVCClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTJwMki3OFQh|ryP M2jSTHNCVkeHUh?=
human SW1710 cell NX3DOIJbT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MlvtTY5pcWKrdHnvckBw\iCqdX3hckBUXzF5MUCgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yMlI6OTR{IN88US=> M{XwNXNCVkeHUh?=
human SK-UT-1 cell MkCyS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MoS3TY5pcWKrdHnvckBw\iCqdX3hckBUUy2XVD2xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Nk4zQTN|OTFOwG0> MmfrV2FPT0WU
human IST-SL1 cell NHfMc3JIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MWHJcohq[mm2aX;uJI9nKGi3bXHuJGlUXC2VTEGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yMlMzOTd2IN88US=> MlP4V2FPT0WU
human SW962 cell MV;Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NHHuOXJKdmirYnn0bY9vKG:oIHj1cYFvKFOZOU[yJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Nk4{Ozd3NzFOwG0> MoPWV2FPT0WU
human EM-2 cell MYXHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NWfKZmRiUW6qaXLpeIlwdiCxZjDoeY1idiCHTT2yJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Nk4{PTN|NzFOwG0> NUjXUXB5W0GQR1XS
human D-263MG cell M2HMNGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NEjiPZNKdmirYnn0bY9vKG:oIHj1cYFvKERvMk[zUWch[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0zNjN6M{K3JO69VQ>? NYf1TJF4W0GQR1XS
human T98G cell M3TSPWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MVfJcohq[mm2aX;uJI9nKGi3bXHuJHQ6QEdiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1{LkO4PFU4KM7:TR?= MlXCV2FPT0WU
human CTB-1 cell MknnS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MoezTY5pcWKrdHnvckBw\iCqdX3hckBEXEJvMTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUKuN|k4PjFizszN MVvTRW5ITVJ?
human Hs-578-T cell NXLJSIhNT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NYexVlBmUW6qaXLpeIlwdiCxZjDoeY1idiCKcz21O|guXCClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTJwNEG1PFch|ryP MnHlV2FPT0WU
human SF126 cell NFXBWFdIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M1:5XWlvcGmkaYTpc44hd2ZiaIXtZY4hW0ZzMk[gZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yMlQ{PjJzIN88US=> MXPTRW5ITVJ?
human NCI-H460 cell NYTnOpQ3T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M3\lW2lvcGmkaYTpc44hd2ZiaIXtZY4hVkOLLVi0OlAh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0zNjR|OUW1JO69VQ>? MVfTRW5ITVJ?
human NCI-H1755 cell M1vUb2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MmLlTY5pcWKrdHnvckBw\iCqdX3hckBPS0lvSEG3OVUh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0zNjV2MESzJO69VQ>? M3rOSHNCVkeHUh?=
human HL-60 cell NW\lfXp6T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NVTCRYFqUW6qaXLpeIlwdiCxZjDoeY1idiCKTD22NEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIvPTRzNUmg{txO MnzVV2FPT0WU
human G-401 cell M2Lh[Wdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MVvJcohq[mm2aX;uJI9nKGi3bXHuJGcuPDBzIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Mj61OlA6QSEQvF2= MoK1V2FPT0WU
human AGS cell NUDEWXBUT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M1rLcWlvcGmkaYTpc44hd2ZiaIXtZY4hSUeVIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Mj61OlI2PyEQvF2= NG\zbZZUSU6JRWK=
human HuO9 cell Ml\XS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NHPT[|JKdmirYnn0bY9vKG:oIHj1cYFvKEi3T{mgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yMlU3PDV4IN88US=> M{XhZnNCVkeHUh?=
human MFE-280 cell MV3Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NUSxT295UW6qaXLpeIlwdiCxZjDoeY1idiCPRlWtNlgxKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:Oi53Nk[4OkDPxE1? NEfJTnRUSU6JRWK=
human NCI-H292 cell NWD0XlZ{T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NHLzOoRKdmirYnn0bY9vKG:oIHj1cYFvKE6FST3INlkzKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:Oi53N{eyNkDPxE1? MXPTRW5ITVJ?
human HuO-3N1 cell NWP5R4g{T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NF;rO3RKdmirYnn0bY9vKG:oIHj1cYFvKEi3Tz2zUlEh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0zNjZyM{C3JO69VQ>? NYPkbXRlW0GQR1XS
human ES3 cell MmLnS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MUjJcohq[mm2aX;uJI9nKGi3bXHuJGVUOyClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTJwNkKyPFUh|ryP NXrDb|dCW0GQR1XS
human LB2241-RCC cell NIDl[JFIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NX;OVmJoUW6qaXLpeIlwdiCxZjDoeY1idiCOQkKyOFEuWkOFIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Mj62PVA4QSEQvF2= MXnTRW5ITVJ?
human NCI-H1155 cell MVjHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NGi2T4lKdmirYnn0bY9vKG:oIHj1cYFvKE6FST3INVE2PSClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTJwNkm0NFUh|ryP MYLTRW5ITVJ?
human SW872 cell NVH5Z25TT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MmXUTY5pcWKrdHnvckBw\iCqdX3hckBUXzh5MjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUKuO|A3PzZizszN NVPoUG9wW0GQR1XS
human MHH-ES-1 cell MYjHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MmfyTY5pcWKrdHnvckBw\iCqdX3hckBOUEhvRWOtNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIvPzJ4M{Og{txO NYPZfm9nW0GQR1XS
human KYSE-150 cell M1PVeWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MnvETY5pcWKrdHnvckBw\iCqdX3hckBMYVOHLUG1NEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIvPzJ7NzFOwG0> NFvCbJRUSU6JRWK=
human MC-IXC cell MlfUS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M4HHNGlvcGmkaYTpc44hd2ZiaIXtZY4hVUNvSWjDJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Nk45QTV|IN88US=> NUnWOmRCW0GQR1XS
human HCC1187 cell NGfmXZlIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M{HqNmlvcGmkaYTpc44hd2ZiaIXtZY4hUEOFMUG4O{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIvQDl4N{eg{txO M1XpcnNCVkeHUh?=
human UMC-11 cell NUXSd5ROT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MXTJcohq[mm2aX;uJI9nKGi3bXHuJHVOSy1zMTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUKuPVA1PzdizszN Mk[0V2FPT0WU
human NB5 cell MULHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MXvJcohq[mm2aX;uJI9nKGi3bXHuJG5DPSClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTJwOUO3NVUh|ryP NI\yR5dUSU6JRWK=
human A2058 cell MUHHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M1v5XGlvcGmkaYTpc44hd2ZiaIXtZY4hSTJyNUigZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yMlk4QDR2IN88US=> M4TsV3NCVkeHUh?=
human Becker cell M4XuUWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M2nmUmlvcGmkaYTpc44hd2ZiaIXtZY4hSmWla3XyJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9N{4xOTFzMjFOwG0> NGLNW2FUSU6JRWK=
human CAS-1 cell MUHHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M4PLT2lvcGmkaYTpc44hd2ZiaIXtZY4hS0GVLUGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2zMlAyPTZ7IN88US=> NITkNIxUSU6JRWK=
human SW780 cell MYTHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M3fRO2lvcGmkaYTpc44hd2ZiaIXtZY4hW1d5OECgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2zMlI2PjB7IN88US=> NHHPe2FUSU6JRWK=
human KM12 cell MYfHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? Ml;STY5pcWKrdHnvckBw\iCqdX3hckBMVTF{IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Mz6zNFE{OiEQvF2= MV3TRW5ITVJ?
human PC-3 cell NYfE[3BuT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NVvKd2lNUW6qaXLpeIlwdiCxZjDoeY1idiCSQz2zJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9OE4yPzRzMTFOwG0> M2THbnNCVkeHUh?=
human A253 cell NYHWRYRTT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M4LicGlvcGmkaYTpc44hd2ZiaIXtZY4hSTJ3MzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUSuNVg5QTNizszN NXPy[HUyW0GQR1XS
human NB10 cell M3;TN2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NYT5b3M6UW6qaXLpeIlwdiCxZjDoeY1idiCQQkGwJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9OE4zOjd5MzFOwG0> MoXjV2FPT0WU
human A172 cell M2fQT2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M1TIUWlvcGmkaYTpc44hd2ZiaIXtZY4hSTF5MjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUSuOFQ2PyEQvF2= MlzuV2FPT0WU
human A498 cell M4jJUGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MV3Jcohq[mm2aX;uJI9nKGi3bXHuJGE1QThiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD12LkW2N|g{KM7:TR?= NGfGbGlUSU6JRWK=
human SW1573 cell NF7JOW9Iem:5dHigbY5pcWKrdHnvckBie3OjeR?= Ml3LTY5pcWKrdHnvckBw\iCqdX3hckBUXzF3N{OgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME22MlkxPDlzIN88US=> M4jYNXNCVkeHUh?=
human 5637 cell NF\oUGxIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NHXNO4FKdmirYnn0bY9vKG:oIHj1cYFvKDV4M{egZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME24MlA4QTB2IN88US=> Mo\sV2FPT0WU
human A388 cell M2ruVmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MY\Jcohq[mm2aX;uJI9nKGi3bXHuJGE{QDhiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1{MT6xN|k5KM7:TR?= NGjxNoxUSU6JRWK=
human U251 cell NVTCZmtjT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MmrtTY5pcWKrdHnvckBw\iCqdX3hckBWOjVzIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MkiuNVE4PSEQvF2= MV7TRW5ITVJ?

... Click to View More Cell Line Experimental Data

Protocol

Kinase Assay:[1]
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Kinase assays:

PDK1 is assayed in a direct kinase assay and a coupled assay format measuring PDK1- and PtdIns-3,4-P2-mediated activation of AKT2. For the coupled assay, the final assay mixture (60 μL) contained: 15 mM MOPS, pH 7.2, 1 mg/mL bovine serum albumin, 18 mM β-glycerol phosphate, 0.7 mM dithiothreitol, 3 mM EGTA, 10 mM MgOAc, 7.5 μM ATP, 0.2 μCi of [γ-33P]ATP, 7.5 μM biotinylated peptide substrate (biotin-ARRRDGGGAQPFRPRAATF), 0.5 μL of PtdIns-3,4-P2-containing phospholipid vesicles, 60 pg of purified recombinant human PDK1, and 172 ng of purified recombinant human AKT2. After incubation for 2 h at room temperature, the biotin-labeled peptide is captured from 10 μl of the assay mixture on streptavidin-coated SPA beads, and product formation is measured by scintillation proximity in a Wallac MicroBeta counter. The product formed is proportional to the time of incubation and to the amount of PDK1 and inactive AKT2 added. PDK1 is added at suboptimal levels so that the assay could sensitively detect inhibitors of AKT2 activation as well as direct inhibitors of PDK1 or AKT2. To measure PDK1 activity directly, the final assay mixture (60 μL) contained 50 mM Tris-HCl, pH 7.5, 0.1 mM EGTA, 0.1 mM EDTA, 0.1% β-mercaptoethanol, 1 mg/mL bovine serum albumin, 10 mM MgOAc, 10 μM ATP, 0.2 μCi of [γ-33P]ATP, 7.5 μM substrate peptide (H2N-ARRRGVTTKTFCGT), and 60 ng of purified recombinant human PDK1. After 4 h at room temperature, we add 25 mM EDTA and spotted a portion of the reaction mixture on Whatman P81 phosphocellulose paper. The filter paper is washed three times with 0.75% phosphoric acid and once with acetone. After drying, the filter-bound labeled peptide is quantified using a Fuji phosphorimager.
Cell Research:[1]
+ Expand
  • Cell lines: MDA-468, PC-3, HCT-116 and MiaPaca cells
  • Concentrations: ~10 μM
  • Incubation Time: 72 hours
  • Method: Cells seeded at a low density (1,500–3,000 cells/well, 0.1 mL/well, 96-well plates) are incubated overnight. Compound treatments are made by adding 10 μL/well of the compound in 1% dimethyl sulfoxide and growth medium (final concentration of dimethyl sulfoxide, 0.1%), followed by brief shaking. Treated cells are incubated for 72 hours, and viability is measured by the addition of 10 μL of the metabolic dye WST-1. The WST-1 signal is read in a plate reader at 450 nm, and a no cell, or zero time cell, background is subtracted to calculate the net signal. Results are reported as the average ± S.E. of two or more replicates.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 100 mg/mL (169.07 mM)
Water slightly soluble or insoluble
Ethanol slightly soluble or insoluble
In vivo Add solvents individually and in order:
30% PEG400+0.5% Tween80+5% propylene glycol
30 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 591.47
Formula

C23H26IN7O2S

CAS No. 702675-74-9
Storage powder
in solvent
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

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PDK Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID