BX-795

Catalog No.S1274

BX-795 Chemical Structure

Molecular Weight(MW): 591.47

BX795 is a potent and specific PDK1 inhibitor with IC50 of 6 nM, 140- and 1600-fold more selective for PDK1 than PKA and PKC in cell-free assays, respectively. Meanwhile, in comparison to GSK3β more than 100-fold selectivity observed for PDK1.

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3 Customer Reviews

  • Induction of basal p62 Ser403 phosphorylation in ULK1/2-deficient MEF was suppressed by BX-795, an inhibitor of TBK1. WT ( Ulk1 +/+/Ulk2 +/+) and Ulk1 -/- /Ulk2 -/-(KO) MEF were treated with NaCl/Pi (Con) or 10 uM BX-795 for 6 h, and subjected to immunoblotting with indicated antibodies.

    FEBS J 2014 281(17), 3816-27. BX-795 purchased from Selleck.

    Virology 2014 450-451, 182-95. BX-795 purchased from Selleck.

  • Western blot analysis of pPRAS40 (T246), pS6 (S240/S244), and pS6 (S235/S236) proteins in (A) HeyA8 cells and (B) SKOV3 cells treated with 3.33 μM or 10 μM inhibitors (BX795 or CCT128930) in three-dimensional cell culture for 24 hours. Ten percent fetal bovine serum was used in A and B.

    PLoS One, 2016, 11(5):e0155052. . BX-795 purchased from Selleck.

Purity & Quality Control

Choose Selective PDK Inhibitors

Biological Activity

Description BX795 is a potent and specific PDK1 inhibitor with IC50 of 6 nM, 140- and 1600-fold more selective for PDK1 than PKA and PKC in cell-free assays, respectively. Meanwhile, in comparison to GSK3β more than 100-fold selectivity observed for PDK1.
Targets
PDK-1 [1]
(Cell-free assay)
c-Kit [1]
(Cell-free assay)
CDK2/CyclinE [1]
(Cell-free assay)
Chk1 [1]
(Cell-free assay)
6 nM 320 nM 430 nM 510 nM
In vitro

BX-795 effectively blocks PDK1 activity in PC-3 cells, as shown by their ability to block phosphorylation of S6K1, Akt, PKCδ, and GSK3β. BX-795 potently inhibits tumor cell growth on plastic with IC50 of 1.6, 1.4, and 1.9 μM for MDA-468, HCT-116 and MiaPaca cells, respectively. In soft agar, BX-795 displays higher growth inhibition with IC50 of 0.72, and 0.25 μM for MDA-468, and PC-3 cells, respectively. [1] In addition, BX-795, as an inhibitor of the TBK1/IKKɛ, blocks TBK1- and IKKε-mediated activation of IRF3 and production of IFN-β. [2] In platelet physiological responses, BX795 produces inhibitory effect on 2-MeSADP-induced or collagen-induced aggregation, ATP secretion and thromboxane generation. [3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
human MV-4-11 cell M2DFRWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M1fwO2lvcGmkaYTpc44hd2ZiaIXtZY4hVVZvND2xNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVM3Njhibl2= NXPGNHB5W0GQR1XS
KRX cells MULGeY5kfGmxbjDhd5NigQ>? MkmxO{BucW6| NGP2[2hKdmirYnn0bY9vKG:oIGPVUW8ufGGpZ3XkJHVNUzFiKIXub45wf25ib4Lp[4lvMSCtaX7hd4Uh\G:vYXnuJIV5eHKnc4Pl[EBqdiCNUmigZ4VtdHNidYPpcochYzN{UG2t[4FudWFvQWTQJIFv\CCveXXsbY4h[mG|aXOgdJJwfGWrbjDzeYJ{fHKjdHWgbY5kfWKjdHXkJIZweiB5IH3pcpM> M3PPd|I3Ojd3Nkix
human NKM-1 cell NUfzT|l5T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NGXEcGNKdmirYnn0bY9vKG:oIHj1cYFvKE6NTT2xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NE4{PjF7NDFOwG0> NYr4SY1DW0GQR1XS
human P30-OHK cell NEPEWHBIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M{fi[2lvcGmkaYTpc44hd2ZiaIXtZY4hWDNyLV;IT{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7LDDJR|UxRTBwNEm2OUDPxE1? NF;mZ|VUSU6JRWK=
human YH-13 cell NHvD[WdIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M2XQfWlvcGmkaYTpc44hd2ZiaIXtZY4hYUhvMUOgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2wMlYzQDh6IN88US=> NEXFXoJUSU6JRWK=
human LXF-289 cell NGq5c5hIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NWD2eJBEUW6qaXLpeIlwdiCxZjDoeY1idiCOWF[tNlg6KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XlwIFnDOVA:OC54NU[5N{DPxE1? MluyV2FPT0WU
human BE-13 cell M3LXN2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NGnBZVNKdmirYnn0bY9vKG:oIHj1cYFvKEKHLUGzJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NE44ODR5NzFOwG0> MXPTRW5ITVJ?
human RS4-11 cell NFXWNGZIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NXv1dXhEUW6qaXLpeIlwdiCxZjDoeY1idiCUU{StNVEh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0xNjd{NUm0JO69VQ>? NXW3NmppW0GQR1XS
human A3-KAW cell NVnpW|hTT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= Ml\lTY5pcWKrdHnvckBw\iCqdX3hckBCOy2NQWegZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2wMlc{ODV3IN88US=> MmT0V2FPT0WU
human PA-1 cell NInXUVdIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MmS0TY5pcWKrdHnvckBw\iCqdX3hckBRSS1zIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MD64NFQzOiEQvF2= MoLSV2FPT0WU
human ES7 cell NVHTT4JYT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NYnLe5A3UW6qaXLpeIlwdiCxZjDoeY1idiCHU{egZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2wMlg{PTZ4IN88US=> MYTTRW5ITVJ?
human ES8 cell NVW1dnBKT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M3rNRmlvcGmkaYTpc44hd2ZiaIXtZY4hTVN6IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MD64OFM{PiEQvF2= NFnJTXNUSU6JRWK=
human SW982 cell NWHlRY1MT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MVzJcohq[mm2aX;uJI9nKGi3bXHuJHNYQTh{IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MD65OVEzPCEQvF2= MWjTRW5ITVJ?
human VA-ES-BJ cell NX\K[G0yT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NInOU4xKdmirYnn0bY9vKG:oIHj1cYFvKF[DLVXTMWJLKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OC57OES2O{DPxE1? MVrTRW5ITVJ?
human 697 cell MnL2S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NHfTVGVKdmirYnn0bY9vKG:oIHj1cYFvKDZ7NzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGuNFE3OjNizszN MXfTRW5ITVJ?
human MOLT-4 cell NFjYbpZIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MmLmTY5pcWKrdHnvckBw\iCqdX3hckBOV0yWLUSgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlA{OjR2IN88US=> MnL5V2FPT0WU
human D-283MED cell M3KwbGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MYfJcohq[mm2aX;uJI9nKGi3bXHuJGQuOjh|TVXEJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU4xOzl2ODFOoI0> M4PGUHNCVkeHUh?=
human ALL-PO cell MV3Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NGT3T5NKdmirYnn0bY9vKG:oIHj1cYFvKEGOTD3QU{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEvODZyN{Og{txO NH\aUlBUSU6JRWK=
human NB14 cell MnvDS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NU\5cm5KUW6qaXLpeIlwdiCxZjDoeY1idiCQQkG0JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU4xPjB6MTFOwG0> MnzWV2FPT0WU
human NTERA-S-cl-D1 cell NVPkXpA3T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M2fTVWlvcGmkaYTpc44hd2ZiaIXtZY4hVlSHUlGtV{1kdC2GMTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGuNFc4PzVizszN M3rLbnNCVkeHUh?=
human BFTC-905 cell NVHid49HT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MlvETY5pcWKrdHnvckBw\iCqdX3hckBDTlSFLUmwOUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEvODhzMEGg{txO NWrHTWNEW0GQR1XS
human H4 cell MorkS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? Mn7lTY5pcWKrdHnvckBw\iCqdX3hckBJPCClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTFwMUCyNFEh|ryP M3r4c3NCVkeHUh?=
human CHP-212 cell MnHQS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MULJcohq[mm2aX;uJI9nKGi3bXHuJGNJWC1{MUKgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlE1ODN5IN88US=> MVjTRW5ITVJ?
human A204 cell M2jZ[Gdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NX7YU2lXUW6qaXLpeIlwdiCxZjDoeY1idiCDMkC0JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU4yPTR4NzFOwG0> M4CwSXNCVkeHUh?=
human NB69 cell NYD6fFhxT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NHzrfmVKdmirYnn0bY9vKG:oIHj1cYFvKE6ENkmgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlE2QDZ3IN88US=> NXXIW4pnW0GQR1XS
human P12-ICHIKAWA cell NHmyUJJIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M1zXUmlvcGmkaYTpc44hd2ZiaIXtZY4hWDF{LVnDTGlMSVeDIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MT6xPFE4OSEQvF2= MYPTRW5ITVJ?
human L-363 cell NUm3UYRIT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= Mne4TY5pcWKrdHnvckBw\iCqdX3hckBNNTN4MzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGuNVgyQTdizszN NFL1WmNUSU6JRWK=
human ES5 cell NEnW[plIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MX3Jcohq[mm2aX;uJI9nKGi3bXHuJGVUPSClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTFwMUmzOVQh|ryP M3\yVnNCVkeHUh?=
human CAL-51 cell NYHHdlBUT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NWXCTFdzUW6qaXLpeIlwdiCxZjDoeY1idiCFQVytOVEh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yNjJ{MUW2JO69VQ>? NFjtUW9USU6JRWK=
human NBsusSR cell MXnHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MWDJcohq[mm2aX;uJI9nKGi3bXHuJG5De3W|U2KgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlI1PTd6IN88US=> NYLDZot4W0GQR1XS
human HOP-92 cell NGHhcW1Iem:5dHigbY5pcWKrdHnvckBie3OjeR?= M2r5O2lvcGmkaYTpc44hd2ZiaIXtZY4hUE:SLUmyJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU4zPzJ7MzFOwG0> NIG5dZlUSU6JRWK=
human DU-4475 cell M2rmc2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M1X4VWlvcGmkaYTpc44hd2ZiaIXtZY4hTFVvNES3OUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEvOjl{NEWg{txO NWjkNWFFW0GQR1XS
human LB1047-RCC cell MlnOS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M1XuU2lvcGmkaYTpc44hd2ZiaIXtZY4hVEJzMES3MXJESyClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTFwMkmyPFEh|ryP MlXQV2FPT0WU
human D-566MG cell NXnWcVJLT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NE[w[XZKdmirYnn0bY9vKG:oIHj1cYFvKERvNU[2UWch[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yNjNyNES4JO69VQ>? MXjTRW5ITVJ?
human A375 cell MVjHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NGrPVoJKdmirYnn0bY9vKG:oIHj1cYFvKEF|N{WgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlMxQDV6IN88US=> M2jLdXNCVkeHUh?=
human ATN-1 cell MWHHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MnT1TY5pcWKrdHnvckBw\iCqdX3hckBCXE5vMTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGuN|cyQDVizszN NV\BSWpkW0GQR1XS
human M059J cell NWDlOZIxT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MWTJcohq[mm2aX;uJI9nKGi3bXHuJG0xPTmMIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MT6zO|Y2OiEQvF2= MlTPV2FPT0WU
human HSC-3 cell M1jTUGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MknTTY5pcWKrdHnvckBw\iCqdX3hckBJW0NvMzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGuOFQzODhizszN MnzIV2FPT0WU
human DOHH-2 cell MVzHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NGrYb2pKdmirYnn0bY9vKG:oIHj1cYFvKESRSFitNkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEvPDV6MUSg{txO MmPMV2FPT0WU
human G-402 cell MWnHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NVfsRmNvUW6qaXLpeIlwdiCxZjDoeY1idiCJLUSwNkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEvPDZ3MkWg{txO NG[0ZVFUSU6JRWK=
human LC-2-ad cell Mo\XS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MX3Jcohq[mm2aX;uJI9nKGi3bXHuJGxENTJvYXSgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlQ4OTN{IN88US=> NGDuSG1USU6JRWK=
human LOXIMVI cell NXrHdnJLT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MmjKTY5pcWKrdHnvckBw\iCqdX3hckBNV1iLTW\JJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU42ODV3MjFOwG0> MmHOV2FPT0WU
human DK-MG cell M2jTVmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NILqUodKdmirYnn0bY9vKG:oIHj1cYFvKESNLV3HJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU42PzJ7ODFOwG0> Mn74V2FPT0WU
human HOS cell M{Dn[Gdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M37Ve2lvcGmkaYTpc44hd2ZiaIXtZY4hUE:VIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MT61O|MxQSEQvF2= NHf6Vo5USU6JRWK=
human BHT-101 cell NVHiZVkyT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NVvESXBJUW6qaXLpeIlwdiCxZjDoeY1idiCESGStNVAyKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OS53N{i3O{DPxE1? NWXUVGNTW0GQR1XS
human U-2-OS cell MXTHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M4rQT2lvcGmkaYTpc44hd2ZiaIXtZY4hXS1{LV;TJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU42QDhyNjFOwG0> Mly4V2FPT0WU
human D-423MG cell MXTHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MVLJcohq[mm2aX;uJI9nKGi3bXHuJGQuPDJ|TVegZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlYxQDB4IN88US=> MYjTRW5ITVJ?
human AN3-CA cell M4PBbWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M{XlUmlvcGmkaYTpc44hd2ZiaIXtZY4hSU5|LVPBJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU43Ozl7MTFOwG0> MlXTV2FPT0WU
human TE-11 cell NVnzb|luT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MoXDTY5pcWKrdHnvckBw\iCqdX3hckBVTS1zMTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGuOlUzQCEQvF2= NITpdFlUSU6JRWK=
human SK-NEP-1 cell MofQS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MlvkTY5pcWKrdHnvckBw\iCqdX3hckBUUy2QRWCtNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEvPjV|N{[g{txO M{W1[XNCVkeHUh?=
human MG-63 cell M4TmcWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NHz3[XdKdmirYnn0bY9vKG:oIHj1cYFvKE2JLU[zJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU43QDV4NzFOwG0> MYHTRW5ITVJ?
human RH-1 cell MUfHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MYHJcohq[mm2aX;uJI9nKGi3bXHuJHJJNTFiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1zLkewNlc1KM7:TR?= MlPHV2FPT0WU
human MDA-MB-157 cell MXzHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M2HsbmlvcGmkaYTpc44hd2ZiaIXtZY4hVUSDLV3CMVE2PyClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTFwN{G2O|Qh|ryP M4rGTXNCVkeHUh?=
human A427 cell NVnYR2gzT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M2L1U2lvcGmkaYTpc44hd2ZiaIXtZY4hSTR{NzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGuO|M2QDlizszN NYPYO4tLW0GQR1XS
human ES1 cell MYjHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NFL4WmxKdmirYnn0bY9vKG:oIHj1cYFvKEWVMTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGuO|U1PTFizszN MVnTRW5ITVJ?
human C32 cell NHHqRVRIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M1rGS2lvcGmkaYTpc44hd2ZiaIXtZY4hSzN{IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MT63OlM6KM7:TR?= M{HzbXNCVkeHUh?=
human LAMA-84 cell NGTJXndIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NIjPOVJKdmirYnn0bY9vKG:oIHj1cYFvKEyDTVGtPFQh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yNjd4OEeyJO69VQ>? M3nCfHNCVkeHUh?=
human YKG-1 cell MWLHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NX\1To5pUW6qaXLpeIlwdiCxZjDoeY1idiC\S1etNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEvPzdzMkSg{txO MXHTRW5ITVJ?
human NCI-H1048 cell NF;JSZBIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M2LmcGlvcGmkaYTpc44hd2ZiaIXtZY4hVkOLLVixNFQ5KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OS55OEWwPUDPxE1? NXjMZolbW0GQR1XS
human KS-1 cell MlmyS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NEO0V2pKdmirYnn0bY9vKG:oIHj1cYFvKEuVLUGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlgzQThizszN MVfTRW5ITVJ?
human JVM-3 cell MmfTS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NIHENWdKdmirYnn0bY9vKG:oIHj1cYFvKEqYTT2zJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU45PjR7MTFOwG0> NGXE[mtUSU6JRWK=
human GI-ME-N cell NUXPcYtPT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MlrMTY5pcWKrdHnvckBw\iCqdX3hckBIUS2PRT3OJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU45PjV|IN88US=> MX7TRW5ITVJ?
human GT3TKB cell MnmxS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? Mke2TY5pcWKrdHnvckBw\iCqdX3hckBIXDOWS1KgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlg6PjR{IN88US=> NWmxUIh3W0GQR1XS
human CHL-1 cell MmjWS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? Ml\UTY5pcWKrdHnvckBw\iCqdX3hckBEUExvMTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGuPVI{PzlizszN M2XqTXNCVkeHUh?=
human CHP-134 cell Mn[wS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MmDnTY5pcWKrdHnvckBw\iCqdX3hckBEUFBvMUO0JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU46PDR4NzFOwG0> NH\0T4tUSU6JRWK=
human 8-MG-BA cell MnjIS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MnS0TY5pcWKrdHnvckBw\iCqdX3hckA5NU2JLVLBJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU46PTd2NDFOwG0> NYDCW5VJW0GQR1XS
human HO-1-N-1 cell NV3zN2FTT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NEfzW21KdmirYnn0bY9vKG:oIHj1cYFvKEiRLUGtUk0yKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OS57N{GxO{DPxE1? NGTnTHBUSU6JRWK=
human SW1088 cell MkKzS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MoDwTY5pcWKrdHnvckBw\iCqdX3hckBUXzFyOEigZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlk6Pjd|IN88US=> NYnPN28{W0GQR1XS
human SW48 cell NYfnOnNQT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MmTyTY5pcWKrdHnvckBw\iCqdX3hckBUXzR6IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Mj6wNlA3PyEQvF2= MkDqV2FPT0WU
human VM-CUB-1 cell M4H3cWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MlnjTY5pcWKrdHnvckBw\iCqdX3hckBXVS2FVVKtNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIvODRzMUmg{txO MoDTV2FPT0WU
human COLO-800 cell NIDiemxIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NInYNnpKdmirYnn0bY9vKG:oIHj1cYFvKEORTF:tPFAxKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:Oi5yNUGzOkDPxE1? NV;MfZVWW0GQR1XS
human TI-73 cell MkjxS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M1;G[GlvcGmkaYTpc44hd2ZiaIXtZY4hXElvN{OgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yMlEyOzl7IN88US=> Mnz0V2FPT0WU
human HN cell NYfHVXo4T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NFXLRXFKdmirYnn0bY9vKG:oIHj1cYFvKEiQIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Mj6xNlE6QCEQvF2= NILH[GdUSU6JRWK=
human DB cell MUnHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? Mom0TY5pcWKrdHnvckBw\iCqdX3hckBFSiClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTJwMUK2N|Eh|ryP MVjTRW5ITVJ?
human Ca9-22 cell MlPNS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NH[1clZKdmirYnn0bY9vKG:oIHj1cYFvKEOjOT2yNkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIvOTJ6NEeg{txO M{PGTHNCVkeHUh?=
human A549 cell NX;Cb5NlT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MVPJcohq[mm2aX;uJI9nKGi3bXHuJGE2PDliY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1{LkGzPFA5KM7:TR?= NUnMdHh2W0GQR1XS
human KGN cell MVTHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NUDpSWNPUW6qaXLpeIlwdiCxZjDoeY1idiCNR16gZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yMlIzPTl3IN88US=> MkDpV2FPT0WU
human BCPAP cell MnjQS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NWLqdWMyUW6qaXLpeIlwdiCxZjDoeY1idiCEQ2DBVEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIvOjNzNUig{txO MlSyV2FPT0WU
human Ramos-2G6-4C10 cell NXfMNWtkT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NVvGbYJbUW6qaXLpeIlwdiCxZjDoeY1idiCUYX3vd{0zTzZvNFOxNEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIvOjN5NUmg{txO Ml3sV2FPT0WU
human OVCAR-5 cell NYfqfZdtT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MWXJcohq[mm2aX;uJI9nKGi3bXHuJG9XS0GULUWgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yMlI4PzN2IN88US=> NFfXS45USU6JRWK=
human KG-1 cell NXH0cYFyT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M2i5UWlvcGmkaYTpc44hd2ZiaIXtZY4hU0dvMTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUKuNlc4QTJizszN M4PVOXNCVkeHUh?=
human CAKI-1 cell MXfHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MonOTY5pcWKrdHnvckBw\iCqdX3hckBESUuLLUGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yMlI5ODV6IN88US=> MljqV2FPT0WU
human QIMR-WIL cell NVv3SWlCT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NWnNd49VUW6qaXLpeIlwdiCxZjDoeY1idiCTSV3SMXdKVCClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTJwMki3OFQh|ryP MnPFV2FPT0WU
human SW1710 cell MWHHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NXzWSXduUW6qaXLpeIlwdiCxZjDoeY1idiCVV{G3NVAh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0zNjJ7MUSyJO69VQ>? NEPyfGJUSU6JRWK=
human SK-UT-1 cell MYHHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M{OyUGlvcGmkaYTpc44hd2ZiaIXtZY4hW0tvVWStNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIvOjl|M{mg{txO MljqV2FPT0WU
human IST-SL1 cell MmLnS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NUi4W|MzUW6qaXLpeIlwdiCxZjDoeY1idiCLU2StV2wyKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:Oi5|MkG3OEDPxE1? NYXX[oRXW0GQR1XS
human SW962 cell MUPHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M3zDfmlvcGmkaYTpc44hd2ZiaIXtZY4hW1d7NkKgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yMlM{PzV5IN88US=> M1TwUnNCVkeHUh?=
human EM-2 cell M4r4N2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MYHJcohq[mm2aX;uJI9nKGi3bXHuJGVONTJiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1{LkO1N|M4KM7:TR?= NF3IUmlUSU6JRWK=
human D-263MG cell NF\HOlNIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NFvxVmJKdmirYnn0bY9vKG:oIHj1cYFvKERvMk[zUWch[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0zNjN6M{K3JO69VQ>? NFvZUWxUSU6JRWK=
human T98G cell MXXHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M2DEOGlvcGmkaYTpc44hd2ZiaIXtZY4hXDl6RzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUKuN|g5PTdizszN NFT6[ZpUSU6JRWK=
human CTB-1 cell NU\4bmRoT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MYDJcohq[mm2aX;uJI9nKGi3bXHuJGNVSi1zIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Mj6zPVc3OSEQvF2= MVTTRW5ITVJ?
human Hs-578-T cell MkTtS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MWLJcohq[mm2aX;uJI9nKGi3bXHuJGh{NTV5OD3UJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Nk41OTV6NzFOwG0> M2W3cnNCVkeHUh?=
human SF126 cell NVXOdnllT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M33mXmlvcGmkaYTpc44hd2ZiaIXtZY4hW0ZzMk[gZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yMlQ{PjJzIN88US=> M17NW3NCVkeHUh?=
human NCI-H460 cell MX3Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MWHJcohq[mm2aX;uJI9nKGi3bXHuJG5EUS2KNE[wJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Nk41Ozl3NTFOwG0> NF7o[mlUSU6JRWK=
human NCI-H1755 cell NV[5e5NbT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NFvMfIZKdmirYnn0bY9vKG:oIHj1cYFvKE6FST3INVc2PSClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTJwNUSwOFMh|ryP NELSO4xUSU6JRWK=
human HL-60 cell NXi1dHg1T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M4nxOWlvcGmkaYTpc44hd2ZiaIXtZY4hUExvNkCgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yMlU1OTV7IN88US=> NEnt[FVUSU6JRWK=
human G-401 cell MWTHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M1XNUGlvcGmkaYTpc44hd2ZiaIXtZY4hTy12MEGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yMlU3ODl7IN88US=> NEKzRZNUSU6JRWK=
human AGS cell NH7CNmpIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MUnJcohq[mm2aX;uJI9nKGi3bXHuJGFIWyClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTJwNU[yOVch|ryP NYTDS4g1W0GQR1XS
human HuO9 cell NXPHOolGT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MXrJcohq[mm2aX;uJI9nKGi3bXHuJGh2VzliY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1{LkW2OFU3KM7:TR?= NE\NRW5USU6JRWK=
human MFE-280 cell M3XxRWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MoXZTY5pcWKrdHnvckBw\iCqdX3hckBOTkVvMkiwJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Nk42PjZ6NjFOwG0> M2L4e3NCVkeHUh?=
human NCI-H292 cell MmLCS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NWPNcGpmUW6qaXLpeIlwdiCxZjDoeY1idiCQQ1mtTFI6OiClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTJwNUe3NlIh|ryP MofJV2FPT0WU
human HuO-3N1 cell MWDHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MYnJcohq[mm2aX;uJI9nKGi3bXHuJGh2Vy1|TkGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yMlYxOzB5IN88US=> MVXTRW5ITVJ?
human ES3 cell MVTHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NInLfXlKdmirYnn0bY9vKG:oIHj1cYFvKEWVMzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUKuOlIzQDVizszN NHrRR25USU6JRWK=
human LB2241-RCC cell NEjUbW5Iem:5dHigbY5pcWKrdHnvckBie3OjeR?= NFn6dGJKdmirYnn0bY9vKG:oIHj1cYFvKEyEMkK0NU1TS0NiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1{Lk[5NFc6KM7:TR?= NYrCXoNVW0GQR1XS
human NCI-H1155 cell NFjLZWNIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MnvHTY5pcWKrdHnvckBw\iCqdX3hckBPS0lvSEGxOVUh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0zNjZ7NEC1JO69VQ>? MVzTRW5ITVJ?
human SW872 cell NEPE[oxIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NEHFb5ZKdmirYnn0bY9vKG:oIHj1cYFvKFOZOEeyJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Nk44ODZ5NjFOwG0> NFjUTpBUSU6JRWK=
human MHH-ES-1 cell MnrnS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MYHJcohq[mm2aX;uJI9nKGi3bXHuJG1JUC2HUz2xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Nk44OjZ|MzFOwG0> MV3TRW5ITVJ?
human KYSE-150 cell M3;3PWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MYfJcohq[mm2aX;uJI9nKGi3bXHuJGt[W0VvMUWwJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Nk44Ojl5IN88US=> MofKV2FPT0WU
human MC-IXC cell NVjMV5Z1T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NEXYbItKdmirYnn0bY9vKG:oIHj1cYFvKE2FLVnYR{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIvQDl3MzFOwG0> NYrPXoRoW0GQR1XS
human HCC1187 cell M2Xqbmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M{PZfWlvcGmkaYTpc44hd2ZiaIXtZY4hUEOFMUG4O{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIvQDl4N{eg{txO MmPlV2FPT0WU
human UMC-11 cell NF:4eHhIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NXHLb3BGUW6qaXLpeIlwdiCxZjDoeY1idiCXTVOtNVEh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0zNjlyNEe3JO69VQ>? NEXPXIJUSU6JRWK=
human NB5 cell NEm5PVhIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NGTFTJpKdmirYnn0bY9vKG:oIHj1cYFvKE6ENTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUKuPVM4OTVizszN M{\2dnNCVkeHUh?=
human A2058 cell MlPXS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NEjldplKdmirYnn0bY9vKG:oIHj1cYFvKEF{MEW4JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Nk46Pzh2NDFOwG0> MlHUV2FPT0WU
human Becker cell M37TdWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MmfCTY5pcWKrdHnvckBw\iCqdX3hckBD\WOtZYKgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2zMlAyOTF{IN88US=> NIPK[nVUSU6JRWK=
human CAS-1 cell MVPHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NVK5cI9mUW6qaXLpeIlwdiCxZjDoeY1idiCFQWOtNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVMvODF3Nkmg{txO MYXTRW5ITVJ?
human SW780 cell NUXLRVljT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NGDkc3FKdmirYnn0bY9vKG:oIHj1cYFvKFOZN{iwJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9N{4zPTZyOTFOwG0> NFHl[ZJUSU6JRWK=
human KM12 cell NGLOZWZIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NHiwVWtKdmirYnn0bY9vKG:oIHj1cYFvKEuPMUKgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2zMlMxOTN{IN88US=> M4WyWHNCVkeHUh?=
human PC-3 cell NGrGb|lIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NES1emRKdmirYnn0bY9vKG:oIHj1cYFvKFCFLUOgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME20MlE4PDFzIN88US=> MVfTRW5ITVJ?
human A253 cell NI[0OlhIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NYnCeoxOUW6qaXLpeIlwdiCxZjDoeY1idiCDMkWzJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9OE4yQDh7MzFOwG0> NFz1fodUSU6JRWK=
human NB10 cell M{fOfGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MlPaTY5pcWKrdHnvckBw\iCqdX3hckBPSjFyIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;ND6yNlc4OyEQvF2= M3\v[nNCVkeHUh?=
human A172 cell Mo\RS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NHrhXZFKdmirYnn0bY9vKG:oIHj1cYFvKEFzN{KgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME20MlQ1PTdizszN MXTTRW5ITVJ?
human A498 cell MlrOS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MXLJcohq[mm2aX;uJI9nKGi3bXHuJGE1QThiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD12LkW2N|g{KM7:TR?= MUnTRW5ITVJ?
human SW1573 cell M1PRVWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M2rjVWlvcGmkaYTpc44hd2ZiaIXtZY4hW1dzNUezJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Ok46ODR7MTFOwG0> M1TNOXNCVkeHUh?=
human 5637 cell MmTMS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NVO4fHFTUW6qaXLpeIlwdiCxZjDoeY1idiB3NkO3JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9PE4xPzlyNDFOwG0> MUXTRW5ITVJ?
human A388 cell MWjHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NIjqcYZKdmirYnn0bY9vKG:oIHj1cYFvKEF|OEigZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yNU4yOzl6IN88US=> NULleY5yW0GQR1XS
human U251 cell Ml7GS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MUjJcohq[mm2aX;uJI9nKGi3bXHuJHUzPTFiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1{OD6xNVc2KM7:TR?= NIL1VGJUSU6JRWK=

... Click to View More Cell Line Experimental Data

Protocol

Kinase Assay:[1]
+ Expand

Kinase assays:

PDK1 is assayed in a direct kinase assay and a coupled assay format measuring PDK1- and PtdIns-3,4-P2-mediated activation of AKT2. For the coupled assay, the final assay mixture (60 μL) contained: 15 mM MOPS, pH 7.2, 1 mg/mL bovine serum albumin, 18 mM β-glycerol phosphate, 0.7 mM dithiothreitol, 3 mM EGTA, 10 mM MgOAc, 7.5 μM ATP, 0.2 μCi of [γ-33P]ATP, 7.5 μM biotinylated peptide substrate (biotin-ARRRDGGGAQPFRPRAATF), 0.5 μL of PtdIns-3,4-P2-containing phospholipid vesicles, 60 pg of purified recombinant human PDK1, and 172 ng of purified recombinant human AKT2. After incubation for 2 h at room temperature, the biotin-labeled peptide is captured from 10 μl of the assay mixture on streptavidin-coated SPA beads, and product formation is measured by scintillation proximity in a Wallac MicroBeta counter. The product formed is proportional to the time of incubation and to the amount of PDK1 and inactive AKT2 added. PDK1 is added at suboptimal levels so that the assay could sensitively detect inhibitors of AKT2 activation as well as direct inhibitors of PDK1 or AKT2. To measure PDK1 activity directly, the final assay mixture (60 μL) contained 50 mM Tris-HCl, pH 7.5, 0.1 mM EGTA, 0.1 mM EDTA, 0.1% β-mercaptoethanol, 1 mg/mL bovine serum albumin, 10 mM MgOAc, 10 μM ATP, 0.2 μCi of [γ-33P]ATP, 7.5 μM substrate peptide (H2N-ARRRGVTTKTFCGT), and 60 ng of purified recombinant human PDK1. After 4 h at room temperature, we add 25 mM EDTA and spotted a portion of the reaction mixture on Whatman P81 phosphocellulose paper. The filter paper is washed three times with 0.75% phosphoric acid and once with acetone. After drying, the filter-bound labeled peptide is quantified using a Fuji phosphorimager.
Cell Research:[1]
+ Expand
  • Cell lines: MDA-468, PC-3, HCT-116 and MiaPaca cells
  • Concentrations: ~10 μM
  • Incubation Time: 72 hours
  • Method: Cells seeded at a low density (1,500–3,000 cells/well, 0.1 mL/well, 96-well plates) are incubated overnight. Compound treatments are made by adding 10 μL/well of the compound in 1% dimethyl sulfoxide and growth medium (final concentration of dimethyl sulfoxide, 0.1%), followed by brief shaking. Treated cells are incubated for 72 hours, and viability is measured by the addition of 10 μL of the metabolic dye WST-1. The WST-1 signal is read in a plate reader at 450 nm, and a no cell, or zero time cell, background is subtracted to calculate the net signal. Results are reported as the average ± S.E. of two or more replicates.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 100 mg/mL (169.07 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
2% DMSO+30% PEG +2% Tween 80+ddH2O
For best results, use promptly after mixing.
4mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 591.47
Formula

C23H26IN7O2S

CAS No. 702675-74-9
Storage powder
in solvent
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

Frequently Asked Questions

  • Question 1:

    Can you suggest an in vivo formulation of S1274 for animal studies?

  • Answer:

    We recommend to use the vehicle 2% DMSO+30% PEG +2% Tween 80+ddH2O for in vivo study.

PDK Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID