BX-795

Catalog No.S1274

BX-795 Chemical Structure

Molecular Weight(MW): 591.47

BX795 is a potent and specific PDK1 inhibitor with IC50 of 6 nM, 140- and 1600-fold more selective for PDK1 than PKA and PKC in cell-free assays, respectively. Meanwhile, in comparison to GSK3β more than 100-fold selectivity observed for PDK1.

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3 Customer Reviews

  • Induction of basal p62 Ser403 phosphorylation in ULK1/2-deficient MEF was suppressed by BX-795, an inhibitor of TBK1. WT ( Ulk1 +/+/Ulk2 +/+) and Ulk1 -/- /Ulk2 -/-(KO) MEF were treated with NaCl/Pi (Con) or 10 uM BX-795 for 6 h, and subjected to immunoblotting with indicated antibodies.

    FEBS J 2014 281(17), 3816-27. BX-795 purchased from Selleck.

    Virology 2014 450-451, 182-95. BX-795 purchased from Selleck.

  • Western blot analysis of pPRAS40 (T246), pS6 (S240/S244), and pS6 (S235/S236) proteins in (A) HeyA8 cells and (B) SKOV3 cells treated with 3.33 μM or 10 μM inhibitors (BX795 or CCT128930) in three-dimensional cell culture for 24 hours. Ten percent fetal bovine serum was used in A and B.

    PLoS One, 2016, 11(5):e0155052. . BX-795 purchased from Selleck.

Purity & Quality Control

Choose Selective PDK Inhibitors

Biological Activity

Description BX795 is a potent and specific PDK1 inhibitor with IC50 of 6 nM, 140- and 1600-fold more selective for PDK1 than PKA and PKC in cell-free assays, respectively. Meanwhile, in comparison to GSK3β more than 100-fold selectivity observed for PDK1.
Targets
PDK-1 [1]
(Cell-free assay)
c-Kit [1]
(Cell-free assay)
CDK2/CyclinE [1]
(Cell-free assay)
Chk1 [1]
(Cell-free assay)
6 nM 320 nM 430 nM 510 nM
In vitro

BX-795 effectively blocks PDK1 activity in PC-3 cells, as shown by their ability to block phosphorylation of S6K1, Akt, PKCδ, and GSK3β. BX-795 potently inhibits tumor cell growth on plastic with IC50 of 1.6, 1.4, and 1.9 μM for MDA-468, HCT-116 and MiaPaca cells, respectively. In soft agar, BX-795 displays higher growth inhibition with IC50 of 0.72, and 0.25 μM for MDA-468, and PC-3 cells, respectively. [1] In addition, BX-795, as an inhibitor of the TBK1/IKKɛ, blocks TBK1- and IKKε-mediated activation of IRF3 and production of IFN-β. [2] In platelet physiological responses, BX795 produces inhibitory effect on 2-MeSADP-induced or collagen-induced aggregation, ATP secretion and thromboxane generation. [3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
human MV-4-11 cell MX;Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? Mmj6TY5pcWKrdHnvckBw\iCqdX3hckBOXi12LUGxJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9N|YvQCCwTR?= NWHDdlRxW0GQR1XS
KRX cells NWXoPG1sTnWwY4Tpc44h[XO|YYm= NFnSVG04KG2rboO= NH3pbVhKdmirYnn0bY9vKG:oIGPVUW8ufGGpZ3XkJHVNUzFiKIXub45wf25ib4Lp[4lvMSCtaX7hd4Uh\G:vYXnuJIV5eHKnc4Pl[EBqdiCNUmigZ4VtdHNidYPpcochYzN{UG2t[4FudWFvQWTQJIFv\CCveXXsbY4h[mG|aXOgdJJwfGWrbjDzeYJ{fHKjdHWgbY5kfWKjdHXkJIZweiB5IH3pcpM> NHvwUYgzPjJ5NU[4NS=>
human NKM-1 cell NGjMc4tIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NEjT[ZhKdmirYnn0bY9vKG:oIHj1cYFvKE6NTT2xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NE4{PjF7NDFOwG0> MmfWV2FPT0WU
human P30-OHK cell NHvHXoRIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NYLvSW5WUW6qaXLpeIlwdiCxZjDoeY1idiCSM{CtU2hMKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImsJGlEPTB;MD60PVY2KM7:TR?= MmXtV2FPT0WU
human YH-13 cell NIKybZNIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MnOxTY5pcWKrdHnvckBw\iCqdX3hckB[UC1zMzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUCuOlI5QDhizszN NUjKOplMW0GQR1XS
human LXF-289 cell NVjKSJZzT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M4LFdGlvcGmkaYTpc44hd2ZiaIXtZY4hVFiILUK4PUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NiCLQ{WwQVAvPjV4OUOg{txO NFLaeoFUSU6JRWK=
human BE-13 cell NXHsRZhvT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M3nHXWlvcGmkaYTpc44hd2ZiaIXtZY4hSkVvMUOgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2wMlcxPDd5IN88US=> MYnTRW5ITVJ?
human RS4-11 cell M2\s[mdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M4HH[mlvcGmkaYTpc44hd2ZiaIXtZY4hWlN2LUGxJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NE44OjV7NDFOwG0> Mki0V2FPT0WU
human A3-KAW cell M1XEUmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M2HQPGlvcGmkaYTpc44hd2ZiaIXtZY4hSTNvS1HXJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NE44OzB3NTFOwG0> MYLTRW5ITVJ?
human PA-1 cell NF:0TG5Iem:5dHigbY5pcWKrdHnvckBie3OjeR?= MUTJcohq[mm2aX;uJI9nKGi3bXHuJHBCNTFiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1yLkiwOFIzKM7:TR?= MkCzV2FPT0WU
human ES7 cell MkjjS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NYn0dItjUW6qaXLpeIlwdiCxZjDoeY1idiCHU{egZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2wMlg{PTZ4IN88US=> MnPhV2FPT0WU
human ES8 cell M{faWGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NVzFT2hbUW6qaXLpeIlwdiCxZjDoeY1idiCHU{igZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2wMlg1OzN4IN88US=> M1LQVnNCVkeHUh?=
human SW982 cell NWDsPXd5T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NFX5WYlKdmirYnn0bY9vKG:oIHj1cYFvKFOZOUiyJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NE46PTF{NDFOwG0> MoqyV2FPT0WU
human VA-ES-BJ cell M17TcGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NV2xUoZ{UW6qaXLpeIlwdiCxZjDoeY1idiCYQT3FV{1DUiClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTBwOUi0Olch|ryP MmrVV2FPT0WU
human 697 cell MULHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NHjheGhKdmirYnn0bY9vKG:oIHj1cYFvKDZ7NzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGuNFE3OjNizszN MUDTRW5ITVJ?
human MOLT-4 cell MlPxS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NInLPWlKdmirYnn0bY9vKG:oIHj1cYFvKE2RTGStOEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEvODN{NESg{txO MnjNV2FPT0WU
human D-283MED cell M{fYZ2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M1nJUGlvcGmkaYTpc44hd2ZiaIXtZY4hTC1{OEPNSWQh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yNjB|OUS4JO6ddQ>? M3HHSXNCVkeHUh?=
human ALL-PO cell NFfKXmxIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M4K5UGlvcGmkaYTpc44hd2ZiaIXtZY4hSUyOLWDPJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU4xPjB5MzFOwG0> MYLTRW5ITVJ?
human NB14 cell NHS0U2tIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MlfuTY5pcWKrdHnvckBw\iCqdX3hckBPSjF2IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MT6wOlA5OSEQvF2= MoLjV2FPT0WU
human NTERA-S-cl-D1 cell NWXBUYNVT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MmPHTY5pcWKrdHnvckBw\iCqdX3hckBPXEWUQT3TMYNtNURzIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MT6wO|c4PSEQvF2= NUHLVmY2W0GQR1XS
human BFTC-905 cell Mlj5S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MoDsTY5pcWKrdHnvckBw\iCqdX3hckBDTlSFLUmwOUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEvODhzMEGg{txO NX[3WGtCW0GQR1XS
human H4 cell M1nJWmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NFzycFdKdmirYnn0bY9vKG:oIHj1cYFvKEh2IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MT6xNFIxOSEQvF2= M1jEO3NCVkeHUh?=
human CHP-212 cell Ml3MS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NILWWYxKdmirYnn0bY9vKG:oIHj1cYFvKEOKUD2yNVIh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yNjF2MEO3JO69VQ>? MmTLV2FPT0WU
human A204 cell MV7Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M{D4VmlvcGmkaYTpc44hd2ZiaIXtZY4hSTJyNDDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGuNVU1PjdizszN NH7YXmxUSU6JRWK=
human NB69 cell NG[wfFhIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NHu5SG5KdmirYnn0bY9vKG:oIHj1cYFvKE6ENkmgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlE2QDZ3IN88US=> NVTZNohoW0GQR1XS
human P12-ICHIKAWA cell NVjLSWYyT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NF2yV3VKdmirYnn0bY9vKG:oIHj1cYFvKFBzMj3JR2hKU0GZQTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGuNVgyPzFizszN M4[4SHNCVkeHUh?=
human L-363 cell M{foeGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NET1XpZKdmirYnn0bY9vKG:oIHj1cYFvKExvM{[zJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU4yQDF7NzFOwG0> MkHzV2FPT0WU
human ES5 cell NG[2dGZIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NIjE[JFKdmirYnn0bY9vKG:oIHj1cYFvKEWVNTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGuNVk{PTRizszN NVL1Z|ZRW0GQR1XS
human CAL-51 cell NWi4c2hzT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NVXocJJDUW6qaXLpeIlwdiCxZjDoeY1idiCFQVytOVEh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yNjJ{MUW2JO69VQ>? NVy2UJpLW0GQR1XS
human NBsusSR cell MlfzS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NYDmcIgxUW6qaXLpeIlwdiCxZjDoeY1idiCQQoP1d3NTKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OS5{NEW3PEDPxE1? Ml\aV2FPT0WU
human HOP-92 cell MnO2S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NEjkUmlKdmirYnn0bY9vKG:oIHj1cYFvKEiRUD25NkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEvOjd{OUOg{txO NYPuOY9NW0GQR1XS
human DU-4475 cell MVrHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M{\5Z2lvcGmkaYTpc44hd2ZiaIXtZY4hTFVvNES3OUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEvOjl{NEWg{txO M2H2V3NCVkeHUh?=
human LB1047-RCC cell M{nyNGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MUnJcohq[mm2aX;uJI9nKGi3bXHuJGxDOTB2Nz3SR2Mh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yNjJ7MkixJO69VQ>? NVjPb4xPW0GQR1XS
human D-566MG cell NGXZU2ZIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MWDJcohq[mm2aX;uJI9nKGi3bXHuJGQuPTZ4TVegZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlMxPDR6IN88US=> MljWV2FPT0WU
human A375 cell MU\Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MoK3TY5pcWKrdHnvckBw\iCqdX3hckBCOzd3IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MT6zNFg2QCEQvF2= M2qzZnNCVkeHUh?=
human ATN-1 cell MYPHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MWjJcohq[mm2aX;uJI9nKGi3bXHuJGFVVi1zIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MT6zO|E5PSEQvF2= MljGV2FPT0WU
human M059J cell M4jXemdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 Mn:3TY5pcWKrdHnvckBw\iCqdX3hckBOODV7SjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGuN|c3PTJizszN MkW2V2FPT0WU
human HSC-3 cell MYfHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M3\UcWlvcGmkaYTpc44hd2ZiaIXtZY4hUFOFLUOgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlQ1OjB6IN88US=> NIC3XmZUSU6JRWK=
human DOHH-2 cell MX\Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MWjJcohq[mm2aX;uJI9nKGi3bXHuJGRQUEhvMjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGuOFU5OTRizszN NHfNOlJUSU6JRWK=
human G-402 cell MnfBS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NHizeodKdmirYnn0bY9vKG:oIHj1cYFvKEdvNECyJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU41PjV{NTFOwG0> MoDMV2FPT0WU
human LC-2-ad cell NHi2NWZIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MVjJcohq[mm2aX;uJI9nKGi3bXHuJGxENTJvYXSgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlQ4OTN{IN88US=> NV[zV2VOW0GQR1XS
human LOXIMVI cell MVvHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MYrJcohq[mm2aX;uJI9nKGi3bXHuJGxQYEmPVlmgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlUxPTV{IN88US=> MYPTRW5ITVJ?
human DK-MG cell NEeyfG5Iem:5dHigbY5pcWKrdHnvckBie3OjeR?= NVy2clVIUW6qaXLpeIlwdiCxZjDoeY1idiCGSz3NS{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEvPTd{OUig{txO NEXp[|ZUSU6JRWK=
human HOS cell NYr0fodtT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NITHZoFKdmirYnn0bY9vKG:oIHj1cYFvKEiRUzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGuOVc{ODlizszN M2SwdXNCVkeHUh?=
human BHT-101 cell MVvHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MVvJcohq[mm2aX;uJI9nKGi3bXHuJGJJXC1zMEGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlU4QDd5IN88US=> NWHobnNuW0GQR1XS
human U-2-OS cell MX7Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MVjJcohq[mm2aX;uJI9nKGi3bXHuJHUuOi2RUzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGuOVg5ODZizszN M4P3d3NCVkeHUh?=
human D-423MG cell NXq1SoFWT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M3juZ2lvcGmkaYTpc44hd2ZiaIXtZY4hTC12MkPNS{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEvPjB6ME[g{txO NHXocVBUSU6JRWK=
human AN3-CA cell NIDxTWhIem:5dHigbY5pcWKrdHnvckBie3OjeR?= Ml\xTY5pcWKrdHnvckBw\iCqdX3hckBCVjNvQ1GgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlY{QTlzIN88US=> MkTEV2FPT0WU
human TE-11 cell MUHHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MXvJcohq[mm2aX;uJI9nKGi3bXHuJHRGNTFzIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MT62OVI5KM7:TR?= NX\QTlNpW0GQR1XS
human SK-NEP-1 cell NUDZU49ET3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NFz0fGFKdmirYnn0bY9vKG:oIHj1cYFvKFONLV7FVE0yKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OS54NUO3OkDPxE1? M1GwV3NCVkeHUh?=
human MG-63 cell M2jkSGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NFLmTodKdmirYnn0bY9vKG:oIHj1cYFvKE2JLU[zJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU43QDV4NzFOwG0> MX;TRW5ITVJ?
human RH-1 cell M2fSe2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NETtNYVKdmirYnn0bY9vKG:oIHj1cYFvKFKKLUGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlcxOjd2IN88US=> NY\5VGNbW0GQR1XS
human MDA-MB-157 cell NGLTPIhIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NWHjZm9LUW6qaXLpeIlwdiCxZjDoeY1idiCPRFGtUWIuOTV5IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MT63NVY4PCEQvF2= M{LGdHNCVkeHUh?=
human A427 cell NXXkVIg6T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M4j5O2lvcGmkaYTpc44hd2ZiaIXtZY4hSTR{NzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGuO|M2QDlizszN M1;LcXNCVkeHUh?=
human ES1 cell MnjvS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MX3Jcohq[mm2aX;uJI9nKGi3bXHuJGVUOSClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTFwN{W0OVEh|ryP M3\2eXNCVkeHUh?=
human C32 cell MlXNS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NV30TYRZUW6qaXLpeIlwdiCxZjDoeY1idiCFM{KgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlc3OzlizszN MVfTRW5ITVJ?
human LAMA-84 cell NHHSPYhIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NVLYNJk6UW6qaXLpeIlwdiCxZjDoeY1idiCOQV3BMVg1KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OS55Nki3NkDPxE1? MnK4V2FPT0WU
human YKG-1 cell NHP1VYJIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NUfmXJZPUW6qaXLpeIlwdiCxZjDoeY1idiC\S1etNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEvPzdzMkSg{txO NFPpV4xUSU6JRWK=
human NCI-H1048 cell Mo\JS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MnLFTY5pcWKrdHnvckBw\iCqdX3hckBPS0lvSEGwOFgh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yNjd6NUC5JO69VQ>? M4TPcXNCVkeHUh?=
human KS-1 cell MXrHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MXrJcohq[mm2aX;uJI9nKGi3bXHuJGtUNTFiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1zLkiyPVgh|ryP MYTTRW5ITVJ?
human JVM-3 cell MorsS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MVrJcohq[mm2aX;uJI9nKGi3bXHuJGpXVS1|IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MT64OlQ6OSEQvF2= NUDTV3U3W0GQR1XS
human GI-ME-N cell M1W5RWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M4nK[mlvcGmkaYTpc44hd2ZiaIXtZY4hT0lvTVWtUkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEvQDZ3MzFOwG0> M4f6WnNCVkeHUh?=
human GT3TKB cell NX;WfWhuT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M4LGUWlvcGmkaYTpc44hd2ZiaIXtZY4hT1R|VFvCJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU45QTZ2MjFOwG0> Mm\KV2FPT0WU
human CHL-1 cell NFTGNYRIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NUmxcXQ1UW6qaXLpeIlwdiCxZjDoeY1idiCFSFytNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEvQTJ|N{mg{txO NFSxbZBUSU6JRWK=
human CHP-134 cell NEHvVpFIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MmL1TY5pcWKrdHnvckBw\iCqdX3hckBEUFBvMUO0JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU46PDR4NzFOwG0> NVnGOXk4W0GQR1XS
human 8-MG-BA cell M1:1UGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NVX6SVR6UW6qaXLpeIlwdiCxZjDoeY1idiB6LV3HMWJCKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OS57NUe0OEDPxE1? MWjTRW5ITVJ?
human HO-1-N-1 cell MV\Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MXPJcohq[mm2aX;uJI9nKGi3bXHuJGhQNTFvTj2xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU46PzFzNzFOwG0> M3Sx[3NCVkeHUh?=
human SW1088 cell NGHtS5lIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MoHwTY5pcWKrdHnvckBw\iCqdX3hckBUXzFyOEigZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlk6Pjd|IN88US=> NEnOTmFUSU6JRWK=
human SW48 cell M3LvOmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 Mmm1TY5pcWKrdHnvckBw\iCqdX3hckBUXzR6IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Mj6wNlA3PyEQvF2= NHnQWXJUSU6JRWK=
human VM-CUB-1 cell NXLFR2M4T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NWC1dFFOUW6qaXLpeIlwdiCxZjDoeY1idiCYTT3DWWIuOSClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTJwMESxNVkh|ryP M4DKd3NCVkeHUh?=
human COLO-800 cell NXzDcnNOT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NVX1O2xrUW6qaXLpeIlwdiCxZjDoeY1idiCFT1zPMVgxOCClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTJwMEWxN|Yh|ryP NF74[Y5USU6JRWK=
human TI-73 cell M1zwfmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M4HkbWlvcGmkaYTpc44hd2ZiaIXtZY4hXElvN{OgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yMlEyOzl7IN88US=> MVzTRW5ITVJ?
human HN cell NFv1WY5Iem:5dHigbY5pcWKrdHnvckBie3OjeR?= NXvCcWxOUW6qaXLpeIlwdiCxZjDoeY1idiCKTjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUKuNVIyQThizszN NHLsbFBUSU6JRWK=
human DB cell MWfHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MnWzTY5pcWKrdHnvckBw\iCqdX3hckBFSiClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTJwMUK2N|Eh|ryP NFH2U4JUSU6JRWK=
human Ca9-22 cell NFS1dVZIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MUnJcohq[mm2aX;uJI9nKGi3bXHuJGNiQS1{MjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUKuNVI5PDdizszN MWrTRW5ITVJ?
human A549 cell M4P2emdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NEfQO4tKdmirYnn0bY9vKG:oIHj1cYFvKEF3NEmgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yMlE{QDB6IN88US=> MmCxV2FPT0WU
human KGN cell NEL6WXVIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NEf6RoJKdmirYnn0bY9vKG:oIHj1cYFvKEuJTjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUKuNlI2QTVizszN MUXTRW5ITVJ?
human BCPAP cell NWmxfZI3T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MV;Jcohq[mm2aX;uJI9nKGi3bXHuJGJEWEGSIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Mj6yN|E2QCEQvF2= NEXrendUSU6JRWK=
human Ramos-2G6-4C10 cell NH7QW|dIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NWHhZpFNUW6qaXLpeIlwdiCxZjDoeY1idiCUYX3vd{0zTzZvNFOxNEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIvOjN5NUmg{txO MWfTRW5ITVJ?
human OVCAR-5 cell NU\BeldMT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MY\Jcohq[mm2aX;uJI9nKGi3bXHuJG9XS0GULUWgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yMlI4PzN2IN88US=> NEDyb5VUSU6JRWK=
human KG-1 cell M{fWfGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NWLhbGh5UW6qaXLpeIlwdiCxZjDoeY1idiCNRz2xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Nk4zPzd7MjFOwG0> Ml\HV2FPT0WU
human CAKI-1 cell MX;Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NXexXW9xUW6qaXLpeIlwdiCxZjDoeY1idiCFQVvJMVEh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0zNjJ6MEW4JO69VQ>? MUXTRW5ITVJ?
human QIMR-WIL cell M2\ufWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NEPGUFdKdmirYnn0bY9vKG:oIHj1cYFvKFGLTWKtW2lNKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:Oi5{OEe0OEDPxE1? NH\mWoZUSU6JRWK=
human SW1710 cell MVvHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M2LvU2lvcGmkaYTpc44hd2ZiaIXtZY4hW1dzN{GwJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Nk4zQTF2MjFOwG0> M1fXW3NCVkeHUh?=
human SK-UT-1 cell M4nxemdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M{fZRmlvcGmkaYTpc44hd2ZiaIXtZY4hW0tvVWStNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIvOjl|M{mg{txO MoOwV2FPT0WU
human IST-SL1 cell M1Pje2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MofuTY5pcWKrdHnvckBw\iCqdX3hckBKW1RvU1yxJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Nk4{OjF5NDFOwG0> NH3pSWlUSU6JRWK=
human SW962 cell M4DtbGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NGXQfmtKdmirYnn0bY9vKG:oIHj1cYFvKFOZOU[yJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Nk4{Ozd3NzFOwG0> M2n5c3NCVkeHUh?=
human EM-2 cell Mmn3S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NFy3NlhKdmirYnn0bY9vKG:oIHj1cYFvKEWPLUKgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yMlM2OzN5IN88US=> NXfFU3NYW0GQR1XS
human D-263MG cell MkjvS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NVL4RmJLUW6qaXLpeIlwdiCxZjDoeY1idiCGLUK2N21IKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:Oi5|OEOyO{DPxE1? MXHTRW5ITVJ?
human T98G cell M4DabGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M{WxeWlvcGmkaYTpc44hd2ZiaIXtZY4hXDl6RzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUKuN|g5PTdizszN NH\kUFVUSU6JRWK=
human CTB-1 cell MUPHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MoOxTY5pcWKrdHnvckBw\iCqdX3hckBEXEJvMTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUKuN|k4PjFizszN MnfsV2FPT0WU
human Hs-578-T cell M1;oN2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NYDiXmJ2UW6qaXLpeIlwdiCxZjDoeY1idiCKcz21O|guXCClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTJwNEG1PFch|ryP NXvwOWtuW0GQR1XS
human SF126 cell NUjzR4lQT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MWjJcohq[mm2aX;uJI9nKGi3bXHuJHNHOTJ4IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Mj60N|YzOSEQvF2= NHTwR4xUSU6JRWK=
human NCI-H460 cell M{fKcGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M{jDfWlvcGmkaYTpc44hd2ZiaIXtZY4hVkOLLVi0OlAh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0zNjR|OUW1JO69VQ>? NE\sTHRUSU6JRWK=
human NCI-H1755 cell MWnHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MVPJcohq[mm2aX;uJI9nKGi3bXHuJG5EUS2KMUe1OUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIvPTRyNEOg{txO MYjTRW5ITVJ?
human HL-60 cell NHLCTnNIem:5dHigbY5pcWKrdHnvckBie3OjeR?= Mm\GTY5pcWKrdHnvckBw\iCqdX3hckBJVC14MDDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUKuOVQyPTlizszN MWjTRW5ITVJ?
human G-401 cell M4jES2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NEDL[ZFKdmirYnn0bY9vKG:oIHj1cYFvKEdvNECxJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Nk42PjB7OTFOwG0> Mn\1V2FPT0WU
human AGS cell NIDDNWtIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NVXUXnJpUW6qaXLpeIlwdiCxZjDoeY1idiCDR2OgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yMlU3OjV5IN88US=> NH;QTWNUSU6JRWK=
human HuO9 cell NGLMXllIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M{XGeGlvcGmkaYTpc44hd2ZiaIXtZY4hUHWROTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUKuOVY1PTZizszN M2fXeXNCVkeHUh?=
human MFE-280 cell MmnFS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NG\ad|VKdmirYnn0bY9vKG:oIHj1cYFvKE2IRT2yPFAh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0zNjV4Nki2JO69VQ>? MVLTRW5ITVJ?
human NCI-H292 cell MnX0S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M{LrdGlvcGmkaYTpc44hd2ZiaIXtZY4hVkOLLViyPVIh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0zNjV5N{KyJO69VQ>? MlfHV2FPT0WU
human HuO-3N1 cell NV\0V3JCT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NF[1UGRKdmirYnn0bY9vKG:oIHj1cYFvKEi3Tz2zUlEh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0zNjZyM{C3JO69VQ>? MYLTRW5ITVJ?
human ES3 cell NHzZ[nVIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NILYcmpKdmirYnn0bY9vKG:oIHj1cYFvKEWVMzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUKuOlIzQDVizszN MmTFV2FPT0WU
human LB2241-RCC cell Mo[3S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M4XrNmlvcGmkaYTpc44hd2ZiaIXtZY4hVEJ{MkSxMXJESyClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTJwNkmwO|kh|ryP NXjofHVYW0GQR1XS
human NCI-H1155 cell MnjVS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MVrJcohq[mm2aX;uJI9nKGi3bXHuJG5EUS2KMUG1OUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIvPjl2MEWg{txO NHS4No5USU6JRWK=
human SW872 cell MnTXS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NWTKPYVlUW6qaXLpeIlwdiCxZjDoeY1idiCVV{i3NkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIvPzB4N{[g{txO M1XEUXNCVkeHUh?=
human MHH-ES-1 cell M2TFbGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NF6yUoZKdmirYnn0bY9vKG:oIHj1cYFvKE2KSD3FV{0yKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:Oi55Mk[zN{DPxE1? MljhV2FPT0WU
human KYSE-150 cell M{S4fWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NVfsepFZUW6qaXLpeIlwdiCxZjDoeY1idiCNWWPFMVE2OCClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTJwN{K5O{DPxE1? NYi3eIZZW0GQR1XS
human MC-IXC cell NInwfI9Iem:5dHigbY5pcWKrdHnvckBie3OjeR?= NI\yXIZKdmirYnn0bY9vKG:oIHj1cYFvKE2FLVnYR{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIvQDl3MzFOwG0> NFPyOGVUSU6JRWK=
human HCC1187 cell M2jvO2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MlzWTY5pcWKrdHnvckBw\iCqdX3hckBJS0NzMUi3JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Nk45QTZ5NzFOwG0> MWjTRW5ITVJ?
human UMC-11 cell NEDmXWZIem:5dHigbY5pcWKrdHnvckBie3OjeR?= Ml3LTY5pcWKrdHnvckBw\iCqdX3hckBWVUNvMUGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yMlkxPDd5IN88US=> MVvTRW5ITVJ?
human NB5 cell M2i2bWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NFjyVVBKdmirYnn0bY9vKG:oIHj1cYFvKE6ENTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUKuPVM4OTVizszN MlvWV2FPT0WU
human A2058 cell MnG4S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M121V2lvcGmkaYTpc44hd2ZiaIXtZY4hSTJyNUigZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yMlk4QDR2IN88US=> NUHUbZIxW0GQR1XS
human Becker cell M3TZNGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NIrHNnJKdmirYnn0bY9vKG:oIHj1cYFvKEKnY3vldkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVMvODFzMUKg{txO NID2PFdUSU6JRWK=
human CAS-1 cell MnvFS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NFHkTFVKdmirYnn0bY9vKG:oIHj1cYFvKEODUz2xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9N{4xOTV4OTFOwG0> M{jaRnNCVkeHUh?=
human SW780 cell Ml3RS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M3rH[mlvcGmkaYTpc44hd2ZiaIXtZY4hW1d5OECgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2zMlI2PjB7IN88US=> M{S4ZnNCVkeHUh?=
human KM12 cell M4jENGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M2q4W2lvcGmkaYTpc44hd2ZiaIXtZY4hU01zMjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUOuN|AyOzJizszN NFq2NFBUSU6JRWK=
human PC-3 cell M2LCS2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MmnQTY5pcWKrdHnvckBw\iCqdX3hckBRSy1|IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;ND6xO|QyOSEQvF2= NFnmTHlUSU6JRWK=
human A253 cell M2rJUWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M17N[2lvcGmkaYTpc44hd2ZiaIXtZY4hSTJ3MzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUSuNVg5QTNizszN MUDTRW5ITVJ?
human NB10 cell MWPHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M{PkeWlvcGmkaYTpc44hd2ZiaIXtZY4hVkJzMDDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUSuNlI4PzNizszN M4fIRXNCVkeHUh?=
human A172 cell Mmf0S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NFfKVWxKdmirYnn0bY9vKG:oIHj1cYFvKEFzN{KgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME20MlQ1PTdizszN NFHMdWtUSU6JRWK=
human A498 cell NFLPVYRIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MUDJcohq[mm2aX;uJI9nKGi3bXHuJGE1QThiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD12LkW2N|g{KM7:TR?= MWnTRW5ITVJ?
human SW1573 cell MVzHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MkHoTY5pcWKrdHnvckBw\iCqdX3hckBUXzF3N{OgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME22MlkxPDlzIN88US=> MVnTRW5ITVJ?
human 5637 cell NHL3S4ZIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NGTqNW5KdmirYnn0bY9vKG:oIHj1cYFvKDV4M{egZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME24MlA4QTB2IN88US=> NFPqeWlUSU6JRWK=
human A388 cell NEK5W|VIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NX7FW4lTUW6qaXLpeIlwdiCxZjDoeY1idiCDM{i4JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NlEvOTN7ODFOwG0> MnWwV2FPT0WU
human U251 cell NYPOOopXT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NI[yS25KdmirYnn0bY9vKG:oIHj1cYFvKFV{NUGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yPE4yOTd3IN88US=> NE\zeXBUSU6JRWK=

... Click to View More Cell Line Experimental Data

Protocol

Kinase Assay:[1]
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Kinase assays:

PDK1 is assayed in a direct kinase assay and a coupled assay format measuring PDK1- and PtdIns-3,4-P2-mediated activation of AKT2. For the coupled assay, the final assay mixture (60 μL) contained: 15 mM MOPS, pH 7.2, 1 mg/mL bovine serum albumin, 18 mM β-glycerol phosphate, 0.7 mM dithiothreitol, 3 mM EGTA, 10 mM MgOAc, 7.5 μM ATP, 0.2 μCi of [γ-33P]ATP, 7.5 μM biotinylated peptide substrate (biotin-ARRRDGGGAQPFRPRAATF), 0.5 μL of PtdIns-3,4-P2-containing phospholipid vesicles, 60 pg of purified recombinant human PDK1, and 172 ng of purified recombinant human AKT2. After incubation for 2 h at room temperature, the biotin-labeled peptide is captured from 10 μl of the assay mixture on streptavidin-coated SPA beads, and product formation is measured by scintillation proximity in a Wallac MicroBeta counter. The product formed is proportional to the time of incubation and to the amount of PDK1 and inactive AKT2 added. PDK1 is added at suboptimal levels so that the assay could sensitively detect inhibitors of AKT2 activation as well as direct inhibitors of PDK1 or AKT2. To measure PDK1 activity directly, the final assay mixture (60 μL) contained 50 mM Tris-HCl, pH 7.5, 0.1 mM EGTA, 0.1 mM EDTA, 0.1% β-mercaptoethanol, 1 mg/mL bovine serum albumin, 10 mM MgOAc, 10 μM ATP, 0.2 μCi of [γ-33P]ATP, 7.5 μM substrate peptide (H2N-ARRRGVTTKTFCGT), and 60 ng of purified recombinant human PDK1. After 4 h at room temperature, we add 25 mM EDTA and spotted a portion of the reaction mixture on Whatman P81 phosphocellulose paper. The filter paper is washed three times with 0.75% phosphoric acid and once with acetone. After drying, the filter-bound labeled peptide is quantified using a Fuji phosphorimager.
Cell Research:[1]
+ Expand
  • Cell lines: MDA-468, PC-3, HCT-116 and MiaPaca cells
  • Concentrations: ~10 μM
  • Incubation Time: 72 hours
  • Method: Cells seeded at a low density (1,500–3,000 cells/well, 0.1 mL/well, 96-well plates) are incubated overnight. Compound treatments are made by adding 10 μL/well of the compound in 1% dimethyl sulfoxide and growth medium (final concentration of dimethyl sulfoxide, 0.1%), followed by brief shaking. Treated cells are incubated for 72 hours, and viability is measured by the addition of 10 μL of the metabolic dye WST-1. The WST-1 signal is read in a plate reader at 450 nm, and a no cell, or zero time cell, background is subtracted to calculate the net signal. Results are reported as the average ± S.E. of two or more replicates.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 100 mg/mL (169.07 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents individually and in order:
30% PEG400+0.5% Tween80+5% propylene glycol
30 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 591.47
Formula

C23H26IN7O2S

CAS No. 702675-74-9
Storage powder
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

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PDK Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID