BX-795

Catalog No.S1274

BX-795 Chemical Structure

Molecular Weight(MW): 591.47

BX795 is a potent and specific PDK1 inhibitor with IC50 of 6 nM, 140- and 1600-fold more selective for PDK1 than PKA and PKC in cell-free assays, respectively. Meanwhile, in comparison to GSK3β more than 100-fold selectivity observed for PDK1.

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3 Customer Reviews

  • Induction of basal p62 Ser403 phosphorylation in ULK1/2-deficient MEF was suppressed by BX-795, an inhibitor of TBK1. WT ( Ulk1 +/+/Ulk2 +/+) and Ulk1 -/- /Ulk2 -/-(KO) MEF were treated with NaCl/Pi (Con) or 10 uM BX-795 for 6 h, and subjected to immunoblotting with indicated antibodies.

    FEBS J 2014 281(17), 3816-27. BX-795 purchased from Selleck.

    Virology 2014 450-451, 182-95. BX-795 purchased from Selleck.

  • Western blot analysis of pPRAS40 (T246), pS6 (S240/S244), and pS6 (S235/S236) proteins in (A) HeyA8 cells and (B) SKOV3 cells treated with 3.33 μM or 10 μM inhibitors (BX795 or CCT128930) in three-dimensional cell culture for 24 hours. Ten percent fetal bovine serum was used in A and B.

    PLoS One, 2016, 11(5):e0155052. . BX-795 purchased from Selleck.

Purity & Quality Control

Choose Selective PDK Inhibitors

Biological Activity

Description BX795 is a potent and specific PDK1 inhibitor with IC50 of 6 nM, 140- and 1600-fold more selective for PDK1 than PKA and PKC in cell-free assays, respectively. Meanwhile, in comparison to GSK3β more than 100-fold selectivity observed for PDK1.
Targets
PDK-1 [1]
(Cell-free assay)
c-Kit [1]
(Cell-free assay)
CDK2/CyclinE [1]
(Cell-free assay)
Chk1 [1]
(Cell-free assay)
6 nM 320 nM 430 nM 510 nM
In vitro

BX-795 effectively blocks PDK1 activity in PC-3 cells, as shown by their ability to block phosphorylation of S6K1, Akt, PKCδ, and GSK3β. BX-795 potently inhibits tumor cell growth on plastic with IC50 of 1.6, 1.4, and 1.9 μM for MDA-468, HCT-116 and MiaPaca cells, respectively. In soft agar, BX-795 displays higher growth inhibition with IC50 of 0.72, and 0.25 μM for MDA-468, and PC-3 cells, respectively. [1] In addition, BX-795, as an inhibitor of the TBK1/IKKɛ, blocks TBK1- and IKKε-mediated activation of IRF3 and production of IFN-β. [2] In platelet physiological responses, BX795 produces inhibitory effect on 2-MeSADP-induced or collagen-induced aggregation, ATP secretion and thromboxane generation. [3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
human MV-4-11 cell Mn3GS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NUnqVHI4UW6qaXLpeIlwdiCxZjDoeY1idiCPVj20MVEyKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OzZwODDuUS=> MknVV2FPT0WU
KRX cells MoLrSpVv[3Srb36gZZN{[Xl? MmLPO{BucW6| NYCyeGN3UW6qaXLpeIlwdiCxZjDTWW1QNXSjZ3fl[EBWVEtzIDj1cotvd3ewIH;ybYdqdilia3nuZZNmKGSxbXHpckBmgHC{ZYPz[YQhcW5iS2LYJINmdGy|IIXzbY5oKFt|MmDdMYdidW2jLVHUVEBidmRibYnlcIlvKGKjc3njJJBzd3SnaX6gd5Vje3S{YYTlJIlv[3WkYYTl[EBnd3JiNzDtbY5{ M4Tr[FI3Ojd3Nkix
human NKM-1 cell NUe0[5VyT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NVO5fnhSUW6qaXLpeIlwdiCxZjDoeY1idiCQS12tNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVAvOzZzOUSg{txO M4\ac3NCVkeHUh?=
human P30-OHK cell NYLjPFB2T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M1jLc2lvcGmkaYTpc44hd2ZiaIXtZY4hWDNyLV;IT{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7LDDJR|UxRTBwNEm2OUDPxE1? M{T4Z3NCVkeHUh?=
human YH-13 cell MkC1S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MXTJcohq[mm2aX;uJI9nKGi3bXHuJHlJNTF|IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MD62Nlg5QCEQvF2= NXnhR5ZDW0GQR1XS
human LXF-289 cell M1TYRWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MlrGTY5pcWKrdHnvckBw\iCqdX3hckBNYEZvMki5JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZkvKEmFNUC9NE43PTZ7MzFOwG0> MlO5V2FPT0WU
human BE-13 cell MnziS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MnvJTY5pcWKrdHnvckBw\iCqdX3hckBDTS1zMzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUCuO|A1PzdizszN MmjrV2FPT0WU
human RS4-11 cell MmD0S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NX3PTWE1UW6qaXLpeIlwdiCxZjDoeY1idiCUU{StNVEh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0xNjd{NUm0JO69VQ>? MUDTRW5ITVJ?
human A3-KAW cell M4fkU2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MWXJcohq[mm2aX;uJI9nKGi3bXHuJGE{NUuDVzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUCuO|MxPTVizszN NFP1RVdUSU6JRWK=
human PA-1 cell MX3Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MnLZTY5pcWKrdHnvckBw\iCqdX3hckBRSS1zIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MD64NFQzOiEQvF2= MU\TRW5ITVJ?
human ES7 cell MYTHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MWTJcohq[mm2aX;uJI9nKGi3bXHuJGVUPyClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTBwOEO1OlYh|ryP MX;TRW5ITVJ?
human ES8 cell NUPsRYVOT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M4f3OGlvcGmkaYTpc44hd2ZiaIXtZY4hTVN6IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MD64OFM{PiEQvF2= NG\x[oNUSU6JRWK=
human SW982 cell NYrLVXVbT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NXfVSFN4UW6qaXLpeIlwdiCxZjDoeY1idiCVV{m4NkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVAvQTVzMkSg{txO M4C5c3NCVkeHUh?=
human VA-ES-BJ cell MV\Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MWLJcohq[mm2aX;uJI9nKGi3bXHuJHZCNUWVLVLKJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NE46QDR4NzFOwG0> MWDTRW5ITVJ?
human 697 cell M1PkU2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M3;pZmlvcGmkaYTpc44hd2ZiaIXtZY4hPjl5IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MT6wNVYzOyEQvF2= MnXUV2FPT0WU
human MOLT-4 cell NUfOd|hUT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NWOye2tyUW6qaXLpeIlwdiCxZjDoeY1idiCPT1zUMVQh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yNjB|MkS0JO69VQ>? M4nFZXNCVkeHUh?=
human D-283MED cell NFSzTnBIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MoTBTY5pcWKrdHnvckBw\iCqdX3hckBFNTJ6M13FSEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEvODN7NEig{rxu NG\G[m5USU6JRWK=
human ALL-PO cell MVLHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MmjMTY5pcWKrdHnvckBw\iCqdX3hckBCVExvUF:gZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlA3ODd|IN88US=> M1\oOnNCVkeHUh?=
human NB14 cell MkLyS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MUfJcohq[mm2aX;uJI9nKGi3bXHuJG5DOTRiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1zLkC2NFgyKM7:TR?= MmXnV2FPT0WU
human NTERA-S-cl-D1 cell NGnPeHVIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M2LsPGlvcGmkaYTpc44hd2ZiaIXtZY4hVlSHUlGtV{1kdC2GMTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGuNFc4PzVizszN MXfTRW5ITVJ?
human BFTC-905 cell Mn7YS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NHH3W5JKdmirYnn0bY9vKG:oIHj1cYFvKEKIVFOtPVA2KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OS5yOEGwNUDPxE1? MVrTRW5ITVJ?
human H4 cell NWriXmg2T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M{D0dmlvcGmkaYTpc44hd2ZiaIXtZY4hUDRiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1zLkGwNlAyKM7:TR?= MYHTRW5ITVJ?
human CHP-212 cell NXvjR3pRT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MmLlTY5pcWKrdHnvckBw\iCqdX3hckBEUFBvMkGyJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU4yPDB|NzFOwG0> M4PuN3NCVkeHUh?=
human A204 cell MkLwS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NHfTfVJKdmirYnn0bY9vKG:oIHj1cYFvKEF{MESgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlE2PDZ5IN88US=> M{TLfnNCVkeHUh?=
human NB69 cell MUnHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NUfnWY1LUW6qaXLpeIlwdiCxZjDoeY1idiCQQk[5JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU4yPTh4NTFOwG0> NWLZdYdqW0GQR1XS
human P12-ICHIKAWA cell Ml3WS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MljuTY5pcWKrdHnvckBw\iCqdX3hckBROTJvSVPITWtCX0FiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1zLkG4NVcyKM7:TR?= M1e2U3NCVkeHUh?=
human L-363 cell NV62boE{T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M{HT[WlvcGmkaYTpc44hd2ZiaIXtZY4hVC1|NkOgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlE5OTl5IN88US=> MonxV2FPT0WU
human ES5 cell MWXHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MkPGTY5pcWKrdHnvckBw\iCqdX3hckBGWzViY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1zLkG5N|U1KM7:TR?= MYfTRW5ITVJ?
human CAL-51 cell NFHGZ4NIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MUDJcohq[mm2aX;uJI9nKGi3bXHuJGNCVC13MTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGuNlIyPTZizszN MWPTRW5ITVJ?
human NBsusSR cell M2rtfGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M1O3T2lvcGmkaYTpc44hd2ZiaIXtZY4hVkK|dYPTVkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEvOjR3N{ig{txO NXrocmhkW0GQR1XS
human HOP-92 cell MnfDS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NXrmNFQxUW6qaXLpeIlwdiCxZjDoeY1idiCKT2CtPVIh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yNjJ5MkmzJO69VQ>? MYfTRW5ITVJ?
human DU-4475 cell MmL1S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NE[3N29KdmirYnn0bY9vKG:oIHj1cYFvKESXLUS0O|Uh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yNjJ7MkS1JO69VQ>? MUfTRW5ITVJ?
human LB1047-RCC cell MY\Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MYnJcohq[mm2aX;uJI9nKGi3bXHuJGxDOTB2Nz3SR2Mh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yNjJ7MkixJO69VQ>? M2D2TnNCVkeHUh?=
human D-566MG cell NF3PWYdIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MmPTTY5pcWKrdHnvckBw\iCqdX3hckBFNTV4Nl3HJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU4{ODR2ODFOwG0> MkiwV2FPT0WU
human A375 cell NH;5blBIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M4KxemlvcGmkaYTpc44hd2ZiaIXtZY4hSTN5NTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGuN|A5PThizszN NUDDbWd6W0GQR1XS
human ATN-1 cell M{nI[Gdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M33uNWlvcGmkaYTpc44hd2ZiaIXtZY4hSVSQLUGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlM4OTh3IN88US=> NXvkPJhWW0GQR1XS
human M059J cell MnK0S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MoD5TY5pcWKrdHnvckBw\iCqdX3hckBOODV7SjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGuN|c3PTJizszN NYPmd5ZqW0GQR1XS
human HSC-3 cell NETKZ4JIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MWPJcohq[mm2aX;uJI9nKGi3bXHuJGhUSy1|IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MT60OFIxQCEQvF2= MVnTRW5ITVJ?
human DOHH-2 cell MkXRS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NUPBWpJjUW6qaXLpeIlwdiCxZjDoeY1idiCGT1jIMVIh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yNjR3OEG0JO69VQ>? NIj4RZBUSU6JRWK=
human G-402 cell Mn7aS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NWTiT21sUW6qaXLpeIlwdiCxZjDoeY1idiCJLUSwNkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEvPDZ3MkWg{txO NWi2W3ZmW0GQR1XS
human LC-2-ad cell M4\PcWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MYfJcohq[mm2aX;uJI9nKGi3bXHuJGxENTJvYXSgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlQ4OTN{IN88US=> MYLTRW5ITVJ?
human LOXIMVI cell MXrHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? Mn;NTY5pcWKrdHnvckBw\iCqdX3hckBNV1iLTW\JJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU42ODV3MjFOwG0> M1SxeHNCVkeHUh?=
human DK-MG cell MlPJS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M2\KWGlvcGmkaYTpc44hd2ZiaIXtZY4hTEtvTVegZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlU4Ojl6IN88US=> MXjTRW5ITVJ?
human HOS cell M1HZcWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M13RVGlvcGmkaYTpc44hd2ZiaIXtZY4hUE:VIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MT61O|MxQSEQvF2= M37OVnNCVkeHUh?=
human BHT-101 cell NH[0XnVIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MlLPTY5pcWKrdHnvckBw\iCqdX3hckBDUFRvMUCxJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU42Pzh5NzFOwG0> NVHUUHptW0GQR1XS
human U-2-OS cell Mk\LS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NX\yeHBUUW6qaXLpeIlwdiCxZjDoeY1idiCXLUKtU3Mh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yNjV6OEC2JO69VQ>? M1L3WnNCVkeHUh?=
human D-423MG cell NH;vOoxIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NYnRXGc4UW6qaXLpeIlwdiCxZjDoeY1idiCGLUSyN21IKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OS54MEiwOkDPxE1? M33uWXNCVkeHUh?=
human AN3-CA cell NVz5fIZoT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NGDxNnlKdmirYnn0bY9vKG:oIHj1cYFvKEGQMz3DRUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEvPjN7OUGg{txO M4DwUHNCVkeHUh?=
human TE-11 cell NYf6fYFjT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= Mnu1TY5pcWKrdHnvckBw\iCqdX3hckBVTS1zMTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGuOlUzQCEQvF2= MmXSV2FPT0WU
human SK-NEP-1 cell MlzKS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NVLFUHF[UW6qaXLpeIlwdiCxZjDoeY1idiCVSz3OSXAuOSClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTFwNkWzO|Yh|ryP M3nZ[3NCVkeHUh?=
human MG-63 cell MmX4S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M{K4R2lvcGmkaYTpc44hd2ZiaIXtZY4hVUdvNkOgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlY5PTZ5IN88US=> MlnUV2FPT0WU
human RH-1 cell MXLHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NGq4c4JKdmirYnn0bY9vKG:oIHj1cYFvKFKKLUGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlcxOjd2IN88US=> MVzTRW5ITVJ?
human MDA-MB-157 cell M1yzNGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MkP5TY5pcWKrdHnvckBw\iCqdX3hckBOTEFvTVKtNVU4KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OS55MU[3OEDPxE1? M3L4RXNCVkeHUh?=
human A427 cell NV35[oE4T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NW[x[WRjUW6qaXLpeIlwdiCxZjDoeY1idiCDNEK3JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU44OzV6OTFOwG0> MlrZV2FPT0WU
human ES1 cell MWHHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M33SV2lvcGmkaYTpc44hd2ZiaIXtZY4hTVNzIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MT63OVQ2OSEQvF2= NFfkTZpUSU6JRWK=
human C32 cell NUWyXplFT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MVrJcohq[mm2aX;uJI9nKGi3bXHuJGM{OiClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTFwN{[zPUDPxE1? MVPTRW5ITVJ?
human LAMA-84 cell MlrpS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NIH0R3FKdmirYnn0bY9vKG:oIHj1cYFvKEyDTVGtPFQh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yNjd4OEeyJO69VQ>? Mo\iV2FPT0WU
human YKG-1 cell M3fHOmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M4D4U2lvcGmkaYTpc44hd2ZiaIXtZY4hYUuJLUGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlc4OTJ2IN88US=> MVzTRW5ITVJ?
human NCI-H1048 cell NVrxXYZLT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MXzJcohq[mm2aX;uJI9nKGi3bXHuJG5EUS2KMUC0PEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEvPzh3MEmg{txO MUPTRW5ITVJ?
human KS-1 cell NGrEVYVIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M4DZVmlvcGmkaYTpc44hd2ZiaIXtZY4hU1NvMTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGuPFI6QCEQvF2= MnnaV2FPT0WU
human JVM-3 cell M2W0[mdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NHjZSGVKdmirYnn0bY9vKG:oIHj1cYFvKEqYTT2zJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU45PjR7MTFOwG0> NUWxbmJnW0GQR1XS
human GI-ME-N cell MYjHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MYjJcohq[mm2aX;uJI9nKGi3bXHuJGdKNU2HLV6gZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlg3PTNizszN MlLBV2FPT0WU
human GT3TKB cell Mn:zS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MlW3TY5pcWKrdHnvckBw\iCqdX3hckBIXDOWS1KgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlg6PjR{IN88US=> MXPTRW5ITVJ?
human CHL-1 cell MYrHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M4HnUGlvcGmkaYTpc44hd2ZiaIXtZY4hS0iOLUGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlkzOzd7IN88US=> NW\kclE5W0GQR1XS
human CHP-134 cell MWXHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NIKzepZKdmirYnn0bY9vKG:oIHj1cYFvKEOKUD2xN|Qh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yNjl2NE[3JO69VQ>? NV3abHZUW0GQR1XS
human 8-MG-BA cell NEO2fJNIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M373SmlvcGmkaYTpc44hd2ZiaIXtZY4hQC2PRz3CRUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEvQTV5NESg{txO MmTTV2FPT0WU
human HO-1-N-1 cell NEG4cnZIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MVHJcohq[mm2aX;uJI9nKGi3bXHuJGhQNTFvTj2xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU46PzFzNzFOwG0> NETneolUSU6JRWK=
human SW1088 cell NV;KXINTT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MWXJcohq[mm2aX;uJI9nKGi3bXHuJHNYOTB6ODDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGuPVk3PzNizszN NVPVRVJkW0GQR1XS
human SW48 cell MVnHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MYXJcohq[mm2aX;uJI9nKGi3bXHuJHNYPDhiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1{LkCyNFY4KM7:TR?= M3vTPHNCVkeHUh?=
human VM-CUB-1 cell NGjKVmxIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NXzqRVZ4UW6qaXLpeIlwdiCxZjDoeY1idiCYTT3DWWIuOSClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTJwMESxNVkh|ryP NFThN5ZUSU6JRWK=
human COLO-800 cell MoXJS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M33TWWlvcGmkaYTpc44hd2ZiaIXtZY4hS0:OTz24NFAh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0zNjB3MUO2JO69VQ>? M3L6fnNCVkeHUh?=
human TI-73 cell NVTL[HRzT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MW\Jcohq[mm2aX;uJI9nKGi3bXHuJHRKNTd|IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Mj6xNVM6QSEQvF2= NH36eIpUSU6JRWK=
human HN cell NYW0UJhsT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NIKwcJRKdmirYnn0bY9vKG:oIHj1cYFvKEiQIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Mj6xNlE6QCEQvF2= MX;TRW5ITVJ?
human DB cell NFjWW|NIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NI\uZ2RKdmirYnn0bY9vKG:oIHj1cYFvKESEIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Mj6xNlY{OSEQvF2= M3zER3NCVkeHUh?=
human Ca9-22 cell MU\Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NUjTV2dQUW6qaXLpeIlwdiCxZjDoeY1idiCFYUmtNlIh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0zNjF{OES3JO69VQ>? MknZV2FPT0WU
human A549 cell MlLlS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MU\Jcohq[mm2aX;uJI9nKGi3bXHuJGE2PDliY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1{LkGzPFA5KM7:TR?= MoixV2FPT0WU
human KGN cell NF65c2hIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NETZcZJKdmirYnn0bY9vKG:oIHj1cYFvKEuJTjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUKuNlI2QTVizszN NWD0Z5I2W0GQR1XS
human BCPAP cell NHLFeIdIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NXTRPIJ{UW6qaXLpeIlwdiCxZjDoeY1idiCEQ2DBVEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIvOjNzNUig{txO MoDuV2FPT0WU
human Ramos-2G6-4C10 cell NH\6bZpIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NFvObpZKdmirYnn0bY9vKG:oIHj1cYFvKFKjbX;zMVJIPi12Q{GwJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Nk4zOzd3OTFOwG0> NUHBRoRFW0GQR1XS
human OVCAR-5 cell NIjyfpNIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NULqeId3UW6qaXLpeIlwdiCxZjDoeY1idiCRVlPBVk02KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:Oi5{N{ezOEDPxE1? MX\TRW5ITVJ?
human KG-1 cell M{DTUmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NXLJfZZ4UW6qaXLpeIlwdiCxZjDoeY1idiCNRz2xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Nk4zPzd7MjFOwG0> MUTTRW5ITVJ?
human CAKI-1 cell NFe1cIJIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NWfWfIZ2UW6qaXLpeIlwdiCxZjDoeY1idiCFQVvJMVEh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0zNjJ6MEW4JO69VQ>? M1PiT3NCVkeHUh?=
human QIMR-WIL cell MXrHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NYTOPHFIUW6qaXLpeIlwdiCxZjDoeY1idiCTSV3SMXdKVCClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTJwMki3OFQh|ryP MnHhV2FPT0WU
human SW1710 cell MV7Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NX;yeINOUW6qaXLpeIlwdiCxZjDoeY1idiCVV{G3NVAh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0zNjJ7MUSyJO69VQ>? NYTSRpJRW0GQR1XS
human SK-UT-1 cell MnnvS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MUnJcohq[mm2aX;uJI9nKGi3bXHuJHNMNVWWLUGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yMlI6OzN7IN88US=> M{fDU3NCVkeHUh?=
human IST-SL1 cell NFPVTG9Iem:5dHigbY5pcWKrdHnvckBie3OjeR?= MlHpTY5pcWKrdHnvckBw\iCqdX3hckBKW1RvU1yxJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Nk4{OjF5NDFOwG0> MW\TRW5ITVJ?
human SW962 cell MWTHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MY\Jcohq[mm2aX;uJI9nKGi3bXHuJHNYQTZ{IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Mj6zN|c2PyEQvF2= MWfTRW5ITVJ?
human EM-2 cell NIXUO|RIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NGLhcFRKdmirYnn0bY9vKG:oIHj1cYFvKEWPLUKgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yMlM2OzN5IN88US=> MUTTRW5ITVJ?
human D-263MG cell MWHHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NWfDTGhkUW6qaXLpeIlwdiCxZjDoeY1idiCGLUK2N21IKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:Oi5|OEOyO{DPxE1? MlrZV2FPT0WU
human T98G cell M1\2bWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NIfpc4RKdmirYnn0bY9vKG:oIHj1cYFvKFR7OFegZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yMlM5QDV5IN88US=> NGTscIlUSU6JRWK=
human CTB-1 cell NH3DdVdIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M4rWW2lvcGmkaYTpc44hd2ZiaIXtZY4hS1SELUGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yMlM6PzZzIN88US=> NXq2cpltW0GQR1XS
human Hs-578-T cell M2PnPWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NWX0ZWNuUW6qaXLpeIlwdiCxZjDoeY1idiCKcz21O|guXCClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTJwNEG1PFch|ryP NF\LNFJUSU6JRWK=
human SF126 cell NFGxdXNIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MkPFTY5pcWKrdHnvckBw\iCqdX3hckBUTjF{NjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUKuOFM3OjFizszN NIrjPVZUSU6JRWK=
human NCI-H460 cell NX75V3dmT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NW\HWGhsUW6qaXLpeIlwdiCxZjDoeY1idiCQQ1mtTFQ3OCClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTJwNEO5OVUh|ryP MkS0V2FPT0WU
human NCI-H1755 cell NG\VTI5Iem:5dHigbY5pcWKrdHnvckBie3OjeR?= M16xfWlvcGmkaYTpc44hd2ZiaIXtZY4hVkOLLVixO|U2KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:Oi53NEC0N{DPxE1? Mnj3V2FPT0WU
human HL-60 cell MUPHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NITWZW9KdmirYnn0bY9vKG:oIHj1cYFvKEiOLU[wJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Nk42PDF3OTFOwG0> M{LNOnNCVkeHUh?=
human G-401 cell MWDHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NELSc21KdmirYnn0bY9vKG:oIHj1cYFvKEdvNECxJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Nk42PjB7OTFOwG0> M3PDeHNCVkeHUh?=
human AGS cell MYXHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NELhdFJKdmirYnn0bY9vKG:oIHj1cYFvKEGJUzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUKuOVYzPTdizszN NFexVohUSU6JRWK=
human HuO9 cell NHvDWHdIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MlLzTY5pcWKrdHnvckBw\iCqdX3hckBJfU97IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Mj61OlQ2PiEQvF2= MVLTRW5ITVJ?
human MFE-280 cell M3zPWWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NFe0RXFKdmirYnn0bY9vKG:oIHj1cYFvKE2IRT2yPFAh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0zNjV4Nki2JO69VQ>? NGq3WWZUSU6JRWK=
human NCI-H292 cell M{mx[2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M2TEWmlvcGmkaYTpc44hd2ZiaIXtZY4hVkOLLViyPVIh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0zNjV5N{KyJO69VQ>? NGric2NUSU6JRWK=
human HuO-3N1 cell NYLEdpZNT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= Mn\CTY5pcWKrdHnvckBw\iCqdX3hckBJfU9vM16xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Nk43ODNyNzFOwG0> M2H3NnNCVkeHUh?=
human ES3 cell NXnyRXJHT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MW\Jcohq[mm2aX;uJI9nKGi3bXHuJGVUOyClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTJwNkKyPFUh|ryP MmXuV2FPT0WU
human LB2241-RCC cell NUHhU3JuT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NHTSNGtKdmirYnn0bY9vKG:oIHj1cYFvKEyEMkK0NU1TS0NiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1{Lk[5NFc6KM7:TR?= MkTlV2FPT0WU
human NCI-H1155 cell NYXo[XlzT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M1TOcmlvcGmkaYTpc44hd2ZiaIXtZY4hVkOLLVixNVU2KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:Oi54OUSwOUDPxE1? NV\MXFhPW0GQR1XS
human SW872 cell MXTHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MXXJcohq[mm2aX;uJI9nKGi3bXHuJHNYQDd{IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Mj63NFY4PiEQvF2= MULTRW5ITVJ?
human MHH-ES-1 cell M1X5UWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MV7Jcohq[mm2aX;uJI9nKGi3bXHuJG1JUC2HUz2xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Nk44OjZ|MzFOwG0> MmK3V2FPT0WU
human KYSE-150 cell NV3DZ|hsT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NXWw[JJYUW6qaXLpeIlwdiCxZjDoeY1idiCNWWPFMVE2OCClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTJwN{K5O{DPxE1? M2\mZXNCVkeHUh?=
human MC-IXC cell M4HES2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NGG0R5NKdmirYnn0bY9vKG:oIHj1cYFvKE2FLVnYR{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIvQDl3MzFOwG0> MUPTRW5ITVJ?
human HCC1187 cell MmLFS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MkHnTY5pcWKrdHnvckBw\iCqdX3hckBJS0NzMUi3JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Nk45QTZ5NzFOwG0> M3y2UnNCVkeHUh?=
human UMC-11 cell MonCS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M1zuNGlvcGmkaYTpc44hd2ZiaIXtZY4hXU2FLUGxJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Nk46ODR5NzFOwG0> M17EWHNCVkeHUh?=
human NB5 cell MWLHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M1HDfmlvcGmkaYTpc44hd2ZiaIXtZY4hVkJ3IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Mj65N|cyPSEQvF2= MlLkV2FPT0WU
human A2058 cell MlnvS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NIO3RXpKdmirYnn0bY9vKG:oIHj1cYFvKEF{MEW4JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Nk46Pzh2NDFOwG0> MmLzV2FPT0WU
human Becker cell Ml\jS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NX\EfotsUW6qaXLpeIlwdiCxZjDoeY1idiCEZXPr[ZIh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0{NjBzMUGyJO69VQ>? NFLkc2FUSU6JRWK=
human CAS-1 cell NULmfpo5T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= Mki1TY5pcWKrdHnvckBw\iCqdX3hckBESVNvMTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUOuNFE2PjlizszN NWr2O49mW0GQR1XS
human SW780 cell Mnj0S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M2T1c2lvcGmkaYTpc44hd2ZiaIXtZY4hW1d5OECgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2zMlI2PjB7IN88US=> MonlV2FPT0WU
human KM12 cell NEj6TnJIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MnT1TY5pcWKrdHnvckBw\iCqdX3hckBMVTF{IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Mz6zNFE{OiEQvF2= NFXQUWtUSU6JRWK=
human PC-3 cell MlXGS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MmSyTY5pcWKrdHnvckBw\iCqdX3hckBRSy1|IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;ND6xO|QyOSEQvF2= MlvKV2FPT0WU
human A253 cell NY\wfIlLT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MmnnTY5pcWKrdHnvckBw\iCqdX3hckBCOjV|IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;ND6xPFg6OyEQvF2= NEnMRZFUSU6JRWK=
human NB10 cell M3\NT2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 Mn;hTY5pcWKrdHnvckBw\iCqdX3hckBPSjFyIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;ND6yNlc4OyEQvF2= Mkf3V2FPT0WU
human A172 cell MmXtS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NYH4enE3UW6qaXLpeIlwdiCxZjDoeY1idiCDMUeyJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9OE41PDV5IN88US=> MYXTRW5ITVJ?
human A498 cell NGq4OZdIem:5dHigbY5pcWKrdHnvckBie3OjeR?= Mn[2TY5pcWKrdHnvckBw\iCqdX3hckBCPDl6IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;ND61OlM5OyEQvF2= MWPTRW5ITVJ?
human SW1573 cell M3;Lb2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NV3IcVhWUW6qaXLpeIlwdiCxZjDoeY1idiCVV{G1O|Mh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF03NjlyNEmxJO69VQ>? MVzTRW5ITVJ?
human 5637 cell M3XBb2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NVrTW3VkUW6qaXLpeIlwdiCxZjDoeY1idiB3NkO3JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9PE4xPzlyNDFOwG0> NHXp[GFUSU6JRWK=
human A388 cell NG[zZWVIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NYj5Sm9RUW6qaXLpeIlwdiCxZjDoeY1idiCDM{i4JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NlEvOTN7ODFOwG0> MlHLV2FPT0WU
human U251 cell MVnHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MWHJcohq[mm2aX;uJI9nKGi3bXHuJHUzPTFiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1{OD6xNVc2KM7:TR?= MWPTRW5ITVJ?

... Click to View More Cell Line Experimental Data

Protocol

Kinase Assay:[1]
+ Expand

Kinase assays:

PDK1 is assayed in a direct kinase assay and a coupled assay format measuring PDK1- and PtdIns-3,4-P2-mediated activation of AKT2. For the coupled assay, the final assay mixture (60 μL) contained: 15 mM MOPS, pH 7.2, 1 mg/mL bovine serum albumin, 18 mM β-glycerol phosphate, 0.7 mM dithiothreitol, 3 mM EGTA, 10 mM MgOAc, 7.5 μM ATP, 0.2 μCi of [γ-33P]ATP, 7.5 μM biotinylated peptide substrate (biotin-ARRRDGGGAQPFRPRAATF), 0.5 μL of PtdIns-3,4-P2-containing phospholipid vesicles, 60 pg of purified recombinant human PDK1, and 172 ng of purified recombinant human AKT2. After incubation for 2 h at room temperature, the biotin-labeled peptide is captured from 10 μl of the assay mixture on streptavidin-coated SPA beads, and product formation is measured by scintillation proximity in a Wallac MicroBeta counter. The product formed is proportional to the time of incubation and to the amount of PDK1 and inactive AKT2 added. PDK1 is added at suboptimal levels so that the assay could sensitively detect inhibitors of AKT2 activation as well as direct inhibitors of PDK1 or AKT2. To measure PDK1 activity directly, the final assay mixture (60 μL) contained 50 mM Tris-HCl, pH 7.5, 0.1 mM EGTA, 0.1 mM EDTA, 0.1% β-mercaptoethanol, 1 mg/mL bovine serum albumin, 10 mM MgOAc, 10 μM ATP, 0.2 μCi of [γ-33P]ATP, 7.5 μM substrate peptide (H2N-ARRRGVTTKTFCGT), and 60 ng of purified recombinant human PDK1. After 4 h at room temperature, we add 25 mM EDTA and spotted a portion of the reaction mixture on Whatman P81 phosphocellulose paper. The filter paper is washed three times with 0.75% phosphoric acid and once with acetone. After drying, the filter-bound labeled peptide is quantified using a Fuji phosphorimager.
Cell Research:[1]
+ Expand
  • Cell lines: MDA-468, PC-3, HCT-116 and MiaPaca cells
  • Concentrations: ~10 μM
  • Incubation Time: 72 hours
  • Method: Cells seeded at a low density (1,500–3,000 cells/well, 0.1 mL/well, 96-well plates) are incubated overnight. Compound treatments are made by adding 10 μL/well of the compound in 1% dimethyl sulfoxide and growth medium (final concentration of dimethyl sulfoxide, 0.1%), followed by brief shaking. Treated cells are incubated for 72 hours, and viability is measured by the addition of 10 μL of the metabolic dye WST-1. The WST-1 signal is read in a plate reader at 450 nm, and a no cell, or zero time cell, background is subtracted to calculate the net signal. Results are reported as the average ± S.E. of two or more replicates.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 100 mg/mL (169.07 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents to the product individually and in order:
2% DMSO+30% PEG +2% Tween 80+ddH2O
For best results, use promptly after mixing.
4mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 591.47
Formula

C23H26IN7O2S

CAS No. 702675-74-9
Storage powder
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

Frequently Asked Questions

  • Question 1:

    Can you suggest an in vivo formulation of S1274 for animal studies?

  • Answer:

    We recommend to use the vehicle 2% DMSO+30% PEG +2% Tween 80+ddH2O for in vivo study.

PDK Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID