BX-795

Catalog No.S1274

BX-795 Chemical Structure

Molecular Weight(MW): 591.47

BX795 is a potent and specific PDK1 inhibitor with IC50 of 6 nM, 140- and 1600-fold more selective for PDK1 than PKA and PKC in cell-free assays, respectively. Meanwhile, in comparison to GSK3β more than 100-fold selectivity observed for PDK1.

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3 Customer Reviews

  • Induction of basal p62 Ser403 phosphorylation in ULK1/2-deficient MEF was suppressed by BX-795, an inhibitor of TBK1. WT ( Ulk1 +/+/Ulk2 +/+) and Ulk1 -/- /Ulk2 -/-(KO) MEF were treated with NaCl/Pi (Con) or 10 uM BX-795 for 6 h, and subjected to immunoblotting with indicated antibodies.

    FEBS J 2014 281(17), 3816-27. BX-795 purchased from Selleck.

    Virology 2014 450-451, 182-95. BX-795 purchased from Selleck.

  • Western blot analysis of pPRAS40 (T246), pS6 (S240/S244), and pS6 (S235/S236) proteins in (A) HeyA8 cells and (B) SKOV3 cells treated with 3.33 μM or 10 μM inhibitors (BX795 or CCT128930) in three-dimensional cell culture for 24 hours. Ten percent fetal bovine serum was used in A and B.

    PLoS One, 2016, 11(5):e0155052. . BX-795 purchased from Selleck.

Purity & Quality Control

Choose Selective PDK Inhibitors

Biological Activity

Description BX795 is a potent and specific PDK1 inhibitor with IC50 of 6 nM, 140- and 1600-fold more selective for PDK1 than PKA and PKC in cell-free assays, respectively. Meanwhile, in comparison to GSK3β more than 100-fold selectivity observed for PDK1.
Targets
PDK-1 [1]
(Cell-free assay)
c-Kit [1]
(Cell-free assay)
CDK2/CyclinE [1]
(Cell-free assay)
Chk1 [1]
(Cell-free assay)
6 nM 320 nM 430 nM 510 nM
In vitro

BX-795 effectively blocks PDK1 activity in PC-3 cells, as shown by their ability to block phosphorylation of S6K1, Akt, PKCδ, and GSK3β. BX-795 potently inhibits tumor cell growth on plastic with IC50 of 1.6, 1.4, and 1.9 μM for MDA-468, HCT-116 and MiaPaca cells, respectively. In soft agar, BX-795 displays higher growth inhibition with IC50 of 0.72, and 0.25 μM for MDA-468, and PC-3 cells, respectively. [1] In addition, BX-795, as an inhibitor of the TBK1/IKKɛ, blocks TBK1- and IKKε-mediated activation of IRF3 and production of IFN-β. [2] In platelet physiological responses, BX795 produces inhibitory effect on 2-MeSADP-induced or collagen-induced aggregation, ATP secretion and thromboxane generation. [3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
human MV-4-11 cell M33lbWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NIq1RXNKdmirYnn0bY9vKG:oIHj1cYFvKE2YLUStNVEh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0{Pi56IH7N MmLRV2FPT0WU
KRX cells Ml25SpVv[3Srb36gZZN{[Xl? M{HJPFchdWmwcx?= MV7Jcohq[mm2aX;uJI9nKFOXTV:teIFo\2WmIGXMT|EhMHWwa37ve44hd3KrZ3nuLUBscW6jc3Wg[I9u[WmwIHX4dJJme3OnZDDpckBMWlhiY3XscJMhfXOrbnegX|MzWF1vZ3HtcYEuSVSSIHHu[EBugWWuaX6gZoF{cWNicILveIVqdiC|dXLzeJJifGViaX7jeYJifGWmIH\vdkA4KG2rboO= NVPaT3UxOjZ{N{W2PFE>
human NKM-1 cell MWLHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MWTJcohq[mm2aX;uJI9nKGi3bXHuJG5MVS1zIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MD6zOlE6PCEQvF2= NGLDVoFUSU6JRWK=
human P30-OHK cell M2P0Umdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M{HGcmlvcGmkaYTpc44hd2ZiaIXtZY4hWDNyLV;IT{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7LDDJR|UxRTBwNEm2OUDPxE1? Mk\1V2FPT0WU
human YH-13 cell MVTHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NH\ZNYVKdmirYnn0bY9vKG:oIHj1cYFvKFmKLUGzJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NE43Ojh6ODFOwG0> MVXTRW5ITVJ?
human LXF-289 cell NUX0bGVGT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M{KydWlvcGmkaYTpc44hd2ZiaIXtZY4hVFiILUK4PUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NiCLQ{WwQVAvPjV4OUOg{txO NYO4R3BmW0GQR1XS
human BE-13 cell MYDHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NE\odZdKdmirYnn0bY9vKG:oIHj1cYFvKEKHLUGzJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NE44ODR5NzFOwG0> NWX1dZlPW0GQR1XS
human RS4-11 cell MkXSS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MkLrTY5pcWKrdHnvckBw\iCqdX3hckBTWzRvMUGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2wMlczPTl2IN88US=> MUXTRW5ITVJ?
human A3-KAW cell MnTLS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NWLRVZVDUW6qaXLpeIlwdiCxZjDoeY1idiCDMz3LRXch[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0xNjd|MEW1JO69VQ>? Mn3HV2FPT0WU
human PA-1 cell M37MWWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MnrQTY5pcWKrdHnvckBw\iCqdX3hckBRSS1zIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MD64NFQzOiEQvF2= M1;TOHNCVkeHUh?=
human ES7 cell MlzCS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? Mlj4TY5pcWKrdHnvckBw\iCqdX3hckBGWzdiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1yLkizOVY3KM7:TR?= NV;nVm1xW0GQR1XS
human ES8 cell M2n5fWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NV\tbo1KUW6qaXLpeIlwdiCxZjDoeY1idiCHU{igZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2wMlg1OzN4IN88US=> NH\aeY9USU6JRWK=
human SW982 cell MljaS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NWXtRlZFUW6qaXLpeIlwdiCxZjDoeY1idiCVV{m4NkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVAvQTVzMkSg{txO NXfMWHV{W0GQR1XS
human VA-ES-BJ cell MWLHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NGDnclRKdmirYnn0bY9vKG:oIHj1cYFvKF[DLVXTMWJLKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OC57OES2O{DPxE1? NXPpeplPW0GQR1XS
human 697 cell NIjSVIZIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NVH1VHRlUW6qaXLpeIlwdiCxZjDoeY1idiB4OUegZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlAyPjJ|IN88US=> NGnn[HRUSU6JRWK=
human MOLT-4 cell M3TIOWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NW\udJYzUW6qaXLpeIlwdiCxZjDoeY1idiCPT1zUMVQh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yNjB|MkS0JO69VQ>? NFLXWVdUSU6JRWK=
human D-283MED cell MnjtS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MmjqTY5pcWKrdHnvckBw\iCqdX3hckBFNTJ6M13FSEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEvODN7NEig{rxu MnvYV2FPT0WU
human ALL-PO cell Ml6zS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MXrJcohq[mm2aX;uJI9nKGi3bXHuJGFNVC2STzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGuNFYxPzNizszN NIn1VmFUSU6JRWK=
human NB14 cell MVTHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MnPSTY5pcWKrdHnvckBw\iCqdX3hckBPSjF2IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MT6wOlA5OSEQvF2= NXzje4pOW0GQR1XS
human NTERA-S-cl-D1 cell MojCS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NXO3[XE{UW6qaXLpeIlwdiCxZjDoeY1idiCQVFXSRU1UNWOuLVSxJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU4xPzd5NTFOwG0> M2fpeXNCVkeHUh?=
human BFTC-905 cell NYPn[ZNXT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NEfjeXBKdmirYnn0bY9vKG:oIHj1cYFvKEKIVFOtPVA2KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OS5yOEGwNUDPxE1? M{HVd3NCVkeHUh?=
human H4 cell M{nZc2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NVTzO|NYUW6qaXLpeIlwdiCxZjDoeY1idiCKNDDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGuNVAzODFizszN NVnmdppGW0GQR1XS
human CHP-212 cell M3y2U2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MmPvTY5pcWKrdHnvckBw\iCqdX3hckBEUFBvMkGyJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU4yPDB|NzFOwG0> NILmfYhUSU6JRWK=
human A204 cell M2rjR2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MYfJcohq[mm2aX;uJI9nKGi3bXHuJGEzODRiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1zLkG1OFY4KM7:TR?= NYiybYFZW0GQR1XS
human NB69 cell MXTHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NVn4bHlLUW6qaXLpeIlwdiCxZjDoeY1idiCQQk[5JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU4yPTh4NTFOwG0> M1T1SHNCVkeHUh?=
human P12-ICHIKAWA cell NV7MW3BbT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NXnodGIxUW6qaXLpeIlwdiCxZjDoeY1idiCSMUKtTWNJUUuDV1GgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlE5OTdzIN88US=> MWnTRW5ITVJ?
human L-363 cell M{fMSGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MWXJcohq[mm2aX;uJI9nKGi3bXHuJGwuOzZ|IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MT6xPFE6PyEQvF2= MVnTRW5ITVJ?
human ES5 cell MWnHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? Ml\lTY5pcWKrdHnvckBw\iCqdX3hckBGWzViY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1zLkG5N|U1KM7:TR?= MXHTRW5ITVJ?
human CAL-51 cell MVXHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? Mn3kTY5pcWKrdHnvckBw\iCqdX3hckBESUxvNUGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlIzOTV4IN88US=> M3vtdXNCVkeHUh?=
human NBsusSR cell MXjHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? Ml;6TY5pcWKrdHnvckBw\iCqdX3hckBPSnO3c2PSJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU4zPDV5ODFOwG0> MnfIV2FPT0WU
human HOP-92 cell MYrHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MYHJcohq[mm2aX;uJI9nKGi3bXHuJGhQWC17MjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGuNlczQTNizszN NU\QWWNNW0GQR1XS
human DU-4475 cell NVnCeYZsT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M2njdGlvcGmkaYTpc44hd2ZiaIXtZY4hTFVvNES3OUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEvOjl{NEWg{txO M1TNRnNCVkeHUh?=
human LB1047-RCC cell Mm\4S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M4TrTWlvcGmkaYTpc44hd2ZiaIXtZY4hVEJzMES3MXJESyClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTFwMkmyPFEh|ryP M4fofHNCVkeHUh?=
human D-566MG cell M{HCfmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NXu1PWI6UW6qaXLpeIlwdiCxZjDoeY1idiCGLUW2Om1IKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OS5|MES0PEDPxE1? NXH2PVJ1W0GQR1XS
human A375 cell NIDiS3dIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M3PkeGlvcGmkaYTpc44hd2ZiaIXtZY4hSTN5NTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGuN|A5PThizszN NFrkO4ZUSU6JRWK=
human ATN-1 cell M1nEdmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NIC1ZpFKdmirYnn0bY9vKG:oIHj1cYFvKEGWTj2xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU4{PzF6NTFOwG0> NYTrc3pEW0GQR1XS
human M059J cell MmnwS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NFewTnZKdmirYnn0bY9vKG:oIHj1cYFvKE1yNUnKJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU4{PzZ3MjFOwG0> NGe3[2ZUSU6JRWK=
human HSC-3 cell NUfNbog6T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M4rNdGlvcGmkaYTpc44hd2ZiaIXtZY4hUFOFLUOgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlQ1OjB6IN88US=> MYTTRW5ITVJ?
human DOHH-2 cell M4LkWmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NET5OWZKdmirYnn0bY9vKG:oIHj1cYFvKESRSFitNkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEvPDV6MUSg{txO NEDkUo1USU6JRWK=
human G-402 cell MX3Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MVzJcohq[mm2aX;uJI9nKGi3bXHuJGcuPDB{IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MT60OlUzPSEQvF2= NHHMclBUSU6JRWK=
human LC-2-ad cell NXfyeY1IT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NWPtVodqUW6qaXLpeIlwdiCxZjDoeY1idiCOQz2yMYFlKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OS52N{GzNkDPxE1? NV;sUJV1W0GQR1XS
human LOXIMVI cell NXX0eJlkT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MorUTY5pcWKrdHnvckBw\iCqdX3hckBNV1iLTW\JJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU42ODV3MjFOwG0> Ml3NV2FPT0WU
human DK-MG cell NEf2TmlIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MXzJcohq[mm2aX;uJI9nKGi3bXHuJGRMNU2JIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MT61O|I6QCEQvF2= NY[zWZpuW0GQR1XS
human HOS cell M1\GNWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MoTFTY5pcWKrdHnvckBw\iCqdX3hckBJV1NiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1zLkW3N|A6KM7:TR?= NXTqR441W0GQR1XS
human BHT-101 cell M1Xxb2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MWDJcohq[mm2aX;uJI9nKGi3bXHuJGJJXC1zMEGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlU4QDd5IN88US=> NWLnOpc3W0GQR1XS
human U-2-OS cell MXnHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MYTJcohq[mm2aX;uJI9nKGi3bXHuJHUuOi2RUzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGuOVg5ODZizszN MVzTRW5ITVJ?
human D-423MG cell MXTHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NYr1ZYpYUW6qaXLpeIlwdiCxZjDoeY1idiCGLUSyN21IKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OS54MEiwOkDPxE1? M33KfHNCVkeHUh?=
human AN3-CA cell MkPiS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M4\oU2lvcGmkaYTpc44hd2ZiaIXtZY4hSU5|LVPBJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU43Ozl7MTFOwG0> M1q5[HNCVkeHUh?=
human TE-11 cell NHrkepFIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MXfJcohq[mm2aX;uJI9nKGi3bXHuJHRGNTFzIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MT62OVI5KM7:TR?= M4DsTHNCVkeHUh?=
human SK-NEP-1 cell NIrHZWpIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NH61epRKdmirYnn0bY9vKG:oIHj1cYFvKFONLV7FVE0yKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OS54NUO3OkDPxE1? M3HDTHNCVkeHUh?=
human MG-63 cell M2[5OGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MnPQTY5pcWKrdHnvckBw\iCqdX3hckBOTy14MzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGuOlg2PjdizszN NUHpdoJ3W0GQR1XS
human RH-1 cell NFrafpdIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MX3Jcohq[mm2aX;uJI9nKGi3bXHuJHJJNTFiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1zLkewNlc1KM7:TR?= MVvTRW5ITVJ?
human MDA-MB-157 cell NUToRZhXT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M2j2e2lvcGmkaYTpc44hd2ZiaIXtZY4hVUSDLV3CMVE2PyClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTFwN{G2O|Qh|ryP NHfkbldUSU6JRWK=
human A427 cell NYCzRWR4T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MlvRTY5pcWKrdHnvckBw\iCqdX3hckBCPDJ5IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MT63N|U5QSEQvF2= MoHEV2FPT0WU
human ES1 cell NHi1d3VIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NHzHVFVKdmirYnn0bY9vKG:oIHj1cYFvKEWVMTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGuO|U1PTFizszN NInWdmlUSU6JRWK=
human C32 cell M{O3Smdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NGHoW2JKdmirYnn0bY9vKG:oIHj1cYFvKEN|MjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGuO|Y{QSEQvF2= M1PTfnNCVkeHUh?=
human LAMA-84 cell MmrIS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M1XhNWlvcGmkaYTpc44hd2ZiaIXtZY4hVEGPQT24OEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEvPzZ6N{Kg{txO NEn0ZY5USU6JRWK=
human YKG-1 cell NYLCVFFJT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MXrJcohq[mm2aX;uJI9nKGi3bXHuJHlMTy1zIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MT63O|EzPCEQvF2= M3LWZXNCVkeHUh?=
human NCI-H1048 cell NXv6NVVFT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= Mln5TY5pcWKrdHnvckBw\iCqdX3hckBPS0lvSEGwOFgh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yNjd6NUC5JO69VQ>? MXPTRW5ITVJ?
human KS-1 cell MmXOS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M4fFSGlvcGmkaYTpc44hd2ZiaIXtZY4hU1NvMTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGuPFI6QCEQvF2= NV:3PY9UW0GQR1XS
human JVM-3 cell MXHHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MYLJcohq[mm2aX;uJI9nKGi3bXHuJGpXVS1|IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MT64OlQ6OSEQvF2= M{fZUXNCVkeHUh?=
human GI-ME-N cell MkL3S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NGHXfY1KdmirYnn0bY9vKG:oIHj1cYFvKEeLLV3FMW4h[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yNjh4NUOg{txO M{jOSXNCVkeHUh?=
human GT3TKB cell MmfsS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NUPxe3l7UW6qaXLpeIlwdiCxZjDoeY1idiCJVEPUT2Ih[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yNjh7NkSyJO69VQ>? NWnobohXW0GQR1XS
human CHL-1 cell Mn\GS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NUPKOXZFUW6qaXLpeIlwdiCxZjDoeY1idiCFSFytNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEvQTJ|N{mg{txO NXzU[ndvW0GQR1XS
human CHP-134 cell NH;RRW9Iem:5dHigbY5pcWKrdHnvckBie3OjeR?= MUfJcohq[mm2aX;uJI9nKGi3bXHuJGNJWC1zM{SgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlk1PDZ5IN88US=> M2nkXnNCVkeHUh?=
human 8-MG-BA cell NVvuSGdDT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NYHYWoRqUW6qaXLpeIlwdiCxZjDoeY1idiB6LV3HMWJCKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OS57NUe0OEDPxE1? MnXUV2FPT0WU
human HO-1-N-1 cell NULFcmdjT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MWXJcohq[mm2aX;uJI9nKGi3bXHuJGhQNTFvTj2xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU46PzFzNzFOwG0> MXPTRW5ITVJ?
human SW1088 cell MYjHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? Ml7RTY5pcWKrdHnvckBw\iCqdX3hckBUXzFyOEigZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlk6Pjd|IN88US=> MYPTRW5ITVJ?
human SW48 cell NX7EeGN3T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NW\EOW9nUW6qaXLpeIlwdiCxZjDoeY1idiCVV{S4JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Nk4xOjB4NzFOwG0> MYjTRW5ITVJ?
human VM-CUB-1 cell M4\oZWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NFqxUHpKdmirYnn0bY9vKG:oIHj1cYFvKF[PLVPVRk0yKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:Oi5yNEGxPUDPxE1? NIrPNWFUSU6JRWK=
human COLO-800 cell NHe5[JVIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M2Kzd2lvcGmkaYTpc44hd2ZiaIXtZY4hS0:OTz24NFAh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0zNjB3MUO2JO69VQ>? M{PHbnNCVkeHUh?=
human TI-73 cell MWXHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MYDJcohq[mm2aX;uJI9nKGi3bXHuJHRKNTd|IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Mj6xNVM6QSEQvF2= NEHjdVJUSU6JRWK=
human HN cell MmP5S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MV7Jcohq[mm2aX;uJI9nKGi3bXHuJGhPKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:Oi5zMkG5PEDPxE1? MmrqV2FPT0WU
human DB cell M4D3SGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M1Ww[mlvcGmkaYTpc44hd2ZiaIXtZY4hTEJiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1{LkGyOlMyKM7:TR?= NEfS[HdUSU6JRWK=
human Ca9-22 cell M1Hafmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M13ifmlvcGmkaYTpc44hd2ZiaIXtZY4hS2F7LUKyJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Nk4yOjh2NzFOwG0> NXLzZ2xDW0GQR1XS
human A549 cell NWjNcYdNT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NE\sRY1KdmirYnn0bY9vKG:oIHj1cYFvKEF3NEmgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yMlE{QDB6IN88US=> MV;TRW5ITVJ?
human KGN cell NWLYclhjT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NID4ZYtKdmirYnn0bY9vKG:oIHj1cYFvKEuJTjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUKuNlI2QTVizszN NECxeXhUSU6JRWK=
human BCPAP cell MmnKS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M1mx[mlvcGmkaYTpc44hd2ZiaIXtZY4hSkOSQWCgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yMlI{OTV6IN88US=> NVjXdXp{W0GQR1XS
human Ramos-2G6-4C10 cell M4PFOGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M4\qeGlvcGmkaYTpc44hd2ZiaIXtZY4hWmGvb4OtNmc3NTSFMUCgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yMlI{PzV7IN88US=> MWfTRW5ITVJ?
human OVCAR-5 cell M3LXcGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NU\IdIQ3UW6qaXLpeIlwdiCxZjDoeY1idiCRVlPBVk02KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:Oi5{N{ezOEDPxE1? MoDGV2FPT0WU
human KG-1 cell M{XLbmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MkfSTY5pcWKrdHnvckBw\iCqdX3hckBMTy1zIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Mj6yO|c6OiEQvF2= MWjTRW5ITVJ?
human CAKI-1 cell NHXpUpZIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NXPqW5lJUW6qaXLpeIlwdiCxZjDoeY1idiCFQVvJMVEh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0zNjJ6MEW4JO69VQ>? M3jVV3NCVkeHUh?=
human QIMR-WIL cell M2r2SGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MmLTTY5pcWKrdHnvckBw\iCqdX3hckBSUU2ULWfJUEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIvOjh5NESg{txO M2\6WnNCVkeHUh?=
human SW1710 cell NWfEcG1kT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MlnWTY5pcWKrdHnvckBw\iCqdX3hckBUXzF5MUCgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yMlI6OTR{IN88US=> MXTTRW5ITVJ?
human SK-UT-1 cell Moj3S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MmHpTY5pcWKrdHnvckBw\iCqdX3hckBUUy2XVD2xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Nk4zQTN|OTFOwG0> MYrTRW5ITVJ?
human IST-SL1 cell M2HOTGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MWDJcohq[mm2aX;uJI9nKGi3bXHuJGlUXC2VTEGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yMlMzOTd2IN88US=> NI\HXW5USU6JRWK=
human SW962 cell MmCzS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MXrJcohq[mm2aX;uJI9nKGi3bXHuJHNYQTZ{IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Mj6zN|c2PyEQvF2= MkW1V2FPT0WU
human EM-2 cell NYTKVFdKT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MWrJcohq[mm2aX;uJI9nKGi3bXHuJGVONTJiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1{LkO1N|M4KM7:TR?= M4\2VnNCVkeHUh?=
human D-263MG cell M3S0Tmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MXvJcohq[mm2aX;uJI9nKGi3bXHuJGQuOjZ|TVegZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yMlM5OzJ5IN88US=> Mn7YV2FPT0WU
human T98G cell Ml;mS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MVfJcohq[mm2aX;uJI9nKGi3bXHuJHQ6QEdiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1{LkO4PFU4KM7:TR?= NFLQd5dUSU6JRWK=
human CTB-1 cell Mm[3S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MlLLTY5pcWKrdHnvckBw\iCqdX3hckBEXEJvMTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUKuN|k4PjFizszN NGnmc3lUSU6JRWK=
human Hs-578-T cell NFOyXFJIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M33jTmlvcGmkaYTpc44hd2ZiaIXtZY4hUHNvNUe4MXQh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0zNjRzNUi3JO69VQ>? NYLRWZBiW0GQR1XS
human SF126 cell M3\ZfWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NXzTbFVrUW6qaXLpeIlwdiCxZjDoeY1idiCVRkGyOkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIvPDN4MkGg{txO Mkj1V2FPT0WU
human NCI-H460 cell M4X6cGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MULJcohq[mm2aX;uJI9nKGi3bXHuJG5EUS2KNE[wJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Nk41Ozl3NTFOwG0> NYHqbpYxW0GQR1XS
human NCI-H1755 cell NH\OeHhIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M3nlO2lvcGmkaYTpc44hd2ZiaIXtZY4hVkOLLVixO|U2KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:Oi53NEC0N{DPxE1? MoGxV2FPT0WU
human HL-60 cell MVXHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MXrJcohq[mm2aX;uJI9nKGi3bXHuJGhNNTZyIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Mj61OFE2QSEQvF2= Mln4V2FPT0WU
human G-401 cell M4\iRmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 Mo[yTY5pcWKrdHnvckBw\iCqdX3hckBINTRyMTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUKuOVYxQTlizszN MlXxV2FPT0WU
human AGS cell MWPHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NGP2cFdKdmirYnn0bY9vKG:oIHj1cYFvKEGJUzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUKuOVYzPTdizszN MmPoV2FPT0WU
human HuO9 cell NVf6eJlyT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MonrTY5pcWKrdHnvckBw\iCqdX3hckBJfU97IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Mj61OlQ2PiEQvF2= NF7kc3VUSU6JRWK=
human MFE-280 cell MVfHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M16zSGlvcGmkaYTpc44hd2ZiaIXtZY4hVU[HLUK4NEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIvPTZ4OE[g{txO MVzTRW5ITVJ?
human NCI-H292 cell Ml;pS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? Mn;uTY5pcWKrdHnvckBw\iCqdX3hckBPS0lvSEK5NkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIvPTd5MkKg{txO M4fhdnNCVkeHUh?=
human HuO-3N1 cell M2\tNmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NWXWZlR5UW6qaXLpeIlwdiCxZjDoeY1idiCKdV:tN24yKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:Oi54MEOwO{DPxE1? MofpV2FPT0WU
human ES3 cell M1W2bmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MoHkTY5pcWKrdHnvckBw\iCqdX3hckBGWzNiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1{Lk[yNlg2KM7:TR?= NEC4eFNUSU6JRWK=
human LB2241-RCC cell NHLFeIhIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M33zVGlvcGmkaYTpc44hd2ZiaIXtZY4hVEJ{MkSxMXJESyClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTJwNkmwO|kh|ryP MVzTRW5ITVJ?
human NCI-H1155 cell M3TuZWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M1HXTmlvcGmkaYTpc44hd2ZiaIXtZY4hVkOLLVixNVU2KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:Oi54OUSwOUDPxE1? Ml:yV2FPT0WU
human SW872 cell MkezS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MWPJcohq[mm2aX;uJI9nKGi3bXHuJHNYQDd{IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Mj63NFY4PiEQvF2= M1iyOXNCVkeHUh?=
human MHH-ES-1 cell NXvneXZjT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MUnJcohq[mm2aX;uJI9nKGi3bXHuJG1JUC2HUz2xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Nk44OjZ|MzFOwG0> M1PsUHNCVkeHUh?=
human KYSE-150 cell Ml3xS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NGnjfXlKdmirYnn0bY9vKG:oIHj1cYFvKEu\U1WtNVUxKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:Oi55Mkm3JO69VQ>? NIS0SmhUSU6JRWK=
human MC-IXC cell MlGyS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NFLjemNKdmirYnn0bY9vKG:oIHj1cYFvKE2FLVnYR{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIvQDl3MzFOwG0> MY\TRW5ITVJ?
human HCC1187 cell M2ntOWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MoXlTY5pcWKrdHnvckBw\iCqdX3hckBJS0NzMUi3JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Nk45QTZ5NzFOwG0> M1PVUnNCVkeHUh?=
human UMC-11 cell MV3Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MnTITY5pcWKrdHnvckBw\iCqdX3hckBWVUNvMUGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yMlkxPDd5IN88US=> NETKW5pUSU6JRWK=
human NB5 cell NVKyXpMzT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NV[zOFdLUW6qaXLpeIlwdiCxZjDoeY1idiCQQkWgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yMlk{PzF3IN88US=> MWXTRW5ITVJ?
human A2058 cell NH7qZ2ZIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M{Lm[2lvcGmkaYTpc44hd2ZiaIXtZY4hSTJyNUigZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yMlk4QDR2IN88US=> NFXvTFBUSU6JRWK=
human Becker cell MnT1S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NFzKPWVKdmirYnn0bY9vKG:oIHj1cYFvKEKnY3vldkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVMvODFzMUKg{txO M1voUnNCVkeHUh?=
human CAS-1 cell NU\w[m5RT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NV\CSZozUW6qaXLpeIlwdiCxZjDoeY1idiCFQWOtNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVMvODF3Nkmg{txO NHH4fVFUSU6JRWK=
human SW780 cell Ml\QS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M1PSbGlvcGmkaYTpc44hd2ZiaIXtZY4hW1d5OECgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2zMlI2PjB7IN88US=> NUD3XJMzW0GQR1XS
human KM12 cell M1fZTmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 Ml3QTY5pcWKrdHnvckBw\iCqdX3hckBMVTF{IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Mz6zNFE{OiEQvF2= M2LiSXNCVkeHUh?=
human PC-3 cell M2nhcWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MnTjTY5pcWKrdHnvckBw\iCqdX3hckBRSy1|IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;ND6xO|QyOSEQvF2= NXfkVmd4W0GQR1XS
human A253 cell NHnwfmtIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NUjDcZJVUW6qaXLpeIlwdiCxZjDoeY1idiCDMkWzJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9OE4yQDh7MzFOwG0> MWPTRW5ITVJ?
human NB10 cell NV3mWXltT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NIjlR|JKdmirYnn0bY9vKG:oIHj1cYFvKE6EMUCgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME20MlIzPzd|IN88US=> NHjzTHdUSU6JRWK=
human A172 cell M{Xufmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MUXJcohq[mm2aX;uJI9nKGi3bXHuJGEyPzJiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD12LkS0OVch|ryP MoXrV2FPT0WU
human A498 cell NXHQNWw1T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NUPST2trUW6qaXLpeIlwdiCxZjDoeY1idiCDNEm4JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9OE42PjN6MzFOwG0> NUS1TGt4W0GQR1XS
human SW1573 cell M3\3[Gdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NEjaUHdKdmirYnn0bY9vKG:oIHj1cYFvKFOZMUW3N{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVYvQTB2OUGg{txO NXfPd5JJW0GQR1XS
human 5637 cell MkntS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NXHOVWtsUW6qaXLpeIlwdiCxZjDoeY1idiB3NkO3JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9PE4xPzlyNDFOwG0> M3XlR3NCVkeHUh?=
human A388 cell MVvHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MV\Jcohq[mm2aX;uJI9nKGi3bXHuJGE{QDhiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1{MT6xN|k5KM7:TR?= M{LvcXNCVkeHUh?=
human U251 cell NVvic5FoT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M{SxbGlvcGmkaYTpc44hd2ZiaIXtZY4hXTJ3MTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUK4MlEyPzVizszN MlzTV2FPT0WU

... Click to View More Cell Line Experimental Data

Protocol

Kinase Assay:[1]
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Kinase assays:

PDK1 is assayed in a direct kinase assay and a coupled assay format measuring PDK1- and PtdIns-3,4-P2-mediated activation of AKT2. For the coupled assay, the final assay mixture (60 μL) contained: 15 mM MOPS, pH 7.2, 1 mg/mL bovine serum albumin, 18 mM β-glycerol phosphate, 0.7 mM dithiothreitol, 3 mM EGTA, 10 mM MgOAc, 7.5 μM ATP, 0.2 μCi of [γ-33P]ATP, 7.5 μM biotinylated peptide substrate (biotin-ARRRDGGGAQPFRPRAATF), 0.5 μL of PtdIns-3,4-P2-containing phospholipid vesicles, 60 pg of purified recombinant human PDK1, and 172 ng of purified recombinant human AKT2. After incubation for 2 h at room temperature, the biotin-labeled peptide is captured from 10 μl of the assay mixture on streptavidin-coated SPA beads, and product formation is measured by scintillation proximity in a Wallac MicroBeta counter. The product formed is proportional to the time of incubation and to the amount of PDK1 and inactive AKT2 added. PDK1 is added at suboptimal levels so that the assay could sensitively detect inhibitors of AKT2 activation as well as direct inhibitors of PDK1 or AKT2. To measure PDK1 activity directly, the final assay mixture (60 μL) contained 50 mM Tris-HCl, pH 7.5, 0.1 mM EGTA, 0.1 mM EDTA, 0.1% β-mercaptoethanol, 1 mg/mL bovine serum albumin, 10 mM MgOAc, 10 μM ATP, 0.2 μCi of [γ-33P]ATP, 7.5 μM substrate peptide (H2N-ARRRGVTTKTFCGT), and 60 ng of purified recombinant human PDK1. After 4 h at room temperature, we add 25 mM EDTA and spotted a portion of the reaction mixture on Whatman P81 phosphocellulose paper. The filter paper is washed three times with 0.75% phosphoric acid and once with acetone. After drying, the filter-bound labeled peptide is quantified using a Fuji phosphorimager.
Cell Research:[1]
+ Expand
  • Cell lines: MDA-468, PC-3, HCT-116 and MiaPaca cells
  • Concentrations: ~10 μM
  • Incubation Time: 72 hours
  • Method: Cells seeded at a low density (1,500–3,000 cells/well, 0.1 mL/well, 96-well plates) are incubated overnight. Compound treatments are made by adding 10 μL/well of the compound in 1% dimethyl sulfoxide and growth medium (final concentration of dimethyl sulfoxide, 0.1%), followed by brief shaking. Treated cells are incubated for 72 hours, and viability is measured by the addition of 10 μL of the metabolic dye WST-1. The WST-1 signal is read in a plate reader at 450 nm, and a no cell, or zero time cell, background is subtracted to calculate the net signal. Results are reported as the average ± S.E. of two or more replicates.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 100 mg/mL (169.07 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents to the product individually and in order:
2% DMSO+30% PEG +2% Tween 80+ddH2O
For best results, use promptly after mixing.
4mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 591.47
Formula

C23H26IN7O2S

CAS No. 702675-74-9
Storage powder
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

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PDK Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID