BX-795

Catalog No.S1274

BX-795 Chemical Structure

Molecular Weight(MW): 591.47

BX795 is a potent and specific PDK1 inhibitor with IC50 of 6 nM, 140- and 1600-fold more selective for PDK1 than PKA and PKC in cell-free assays, respectively. Meanwhile, in comparison to GSK3β more than 100-fold selectivity observed for PDK1.

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3 Customer Reviews

  • Induction of basal p62 Ser403 phosphorylation in ULK1/2-deficient MEF was suppressed by BX-795, an inhibitor of TBK1. WT ( Ulk1 +/+/Ulk2 +/+) and Ulk1 -/- /Ulk2 -/-(KO) MEF were treated with NaCl/Pi (Con) or 10 uM BX-795 for 6 h, and subjected to immunoblotting with indicated antibodies.

    FEBS J 2014 281(17), 3816-27. BX-795 purchased from Selleck.

    Virology 2014 450-451, 182-95. BX-795 purchased from Selleck.

  • Western blot analysis of pPRAS40 (T246), pS6 (S240/S244), and pS6 (S235/S236) proteins in (A) HeyA8 cells and (B) SKOV3 cells treated with 3.33 μM or 10 μM inhibitors (BX795 or CCT128930) in three-dimensional cell culture for 24 hours. Ten percent fetal bovine serum was used in A and B.

    PLoS One, 2016, 11(5):e0155052. . BX-795 purchased from Selleck.

Purity & Quality Control

Choose Selective PDK Inhibitors

Biological Activity

Description BX795 is a potent and specific PDK1 inhibitor with IC50 of 6 nM, 140- and 1600-fold more selective for PDK1 than PKA and PKC in cell-free assays, respectively. Meanwhile, in comparison to GSK3β more than 100-fold selectivity observed for PDK1.
Targets
PDK-1 [1]
(Cell-free assay)
c-Kit [1]
(Cell-free assay)
CDK2/CyclinE [1]
(Cell-free assay)
Chk1 [1]
(Cell-free assay)
6 nM 320 nM 430 nM 510 nM
In vitro

BX-795 effectively blocks PDK1 activity in PC-3 cells, as shown by their ability to block phosphorylation of S6K1, Akt, PKCδ, and GSK3β. BX-795 potently inhibits tumor cell growth on plastic with IC50 of 1.6, 1.4, and 1.9 μM for MDA-468, HCT-116 and MiaPaca cells, respectively. In soft agar, BX-795 displays higher growth inhibition with IC50 of 0.72, and 0.25 μM for MDA-468, and PC-3 cells, respectively. [1] In addition, BX-795, as an inhibitor of the TBK1/IKKɛ, blocks TBK1- and IKKε-mediated activation of IRF3 and production of IFN-β. [2] In platelet physiological responses, BX795 produces inhibitory effect on 2-MeSADP-induced or collagen-induced aggregation, ATP secretion and thromboxane generation. [3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
human MV-4-11 cell NUnxZlhoT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MoP2TY5pcWKrdHnvckBw\iCqdX3hckBOXi12LUGxJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9N|YvQCCwTR?= MUnTRW5ITVJ?
KRX cells MmfuSpVv[3Srb36gZZN{[Xl? NE\wZ2I4KG2rboO= Ml3qTY5pcWKrdHnvckBw\iCVVV3PMZRi\2enZDDVUGsyKCi3bnvuc5dvKG:{aXfpckkhc2mwYYPlJIRwdWGrbjDlfJBz\XO|ZXSgbY4hU1K[IHPlcIx{KHW|aX7nJHs{OlCfLXfhcY1iNUGWUDDhcoQhdXmnbHnuJIJie2mlIIDyc5RmcW5ic4Xid5Rz[XSnIHnuZ5Vj[XSnZDDmc5IhPyCvaX7z NEHGZVYzPjJ5NU[4NS=>
human NKM-1 cell NXTYephvT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MkT2TY5pcWKrdHnvckBw\iCqdX3hckBPU01vMTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUCuN|YyQTRizszN NX7JdplCW0GQR1XS
human P30-OHK cell NUDxNHYzT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MXHJcohq[mm2aX;uJI9nKGi3bXHuJHA{OC2RSFugZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSxiSVO1NF0xNjR7NkWg{txO M2fNVXNCVkeHUh?=
human YH-13 cell MXXHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NWDzfWJ4UW6qaXLpeIlwdiCxZjDoeY1idiC\SD2xN{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVAvPjJ6OEig{txO M1LjT3NCVkeHUh?=
human LXF-289 cell NELGSWlIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NFznfnZKdmirYnn0bY9vKG:oIHj1cYFvKEy[Rj2yPFkh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigS5iSVO1NF0xNjZ3NkmzJO69VQ>? MXTTRW5ITVJ?
human BE-13 cell MnLLS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MnK3TY5pcWKrdHnvckBw\iCqdX3hckBDTS1zMzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUCuO|A1PzdizszN NEHV[XJUSU6JRWK=
human RS4-11 cell MULHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MknxTY5pcWKrdHnvckBw\iCqdX3hckBTWzRvMUGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2wMlczPTl2IN88US=> NITNR2dUSU6JRWK=
human A3-KAW cell NYf3dJNNT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MUXJcohq[mm2aX;uJI9nKGi3bXHuJGE{NUuDVzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUCuO|MxPTVizszN NX\Nc2x7W0GQR1XS
human PA-1 cell M4nnTGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M2PyRmlvcGmkaYTpc44hd2ZiaIXtZY4hWEFvMTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUCuPFA1OjJizszN MojjV2FPT0WU
human ES7 cell MVzHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NU\YNpZ3UW6qaXLpeIlwdiCxZjDoeY1idiCHU{egZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2wMlg{PTZ4IN88US=> M3zEeXNCVkeHUh?=
human ES8 cell M1TOV2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M3e1VmlvcGmkaYTpc44hd2ZiaIXtZY4hTVN6IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MD64OFM{PiEQvF2= NXjadmpwW0GQR1XS
human SW982 cell NYDhPVl2T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NV30Z25qUW6qaXLpeIlwdiCxZjDoeY1idiCVV{m4NkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVAvQTVzMkSg{txO NX71NGU1W0GQR1XS
human VA-ES-BJ cell MVLHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M2XyOmlvcGmkaYTpc44hd2ZiaIXtZY4hXkFvRWOtRmoh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0xNjl6NE[3JO69VQ>? NF22PJNUSU6JRWK=
human 697 cell NFjjUWVIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MWDJcohq[mm2aX;uJI9nKGi3bXHuJFY6PyClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTFwMEG2NlMh|ryP NELQZY1USU6JRWK=
human MOLT-4 cell MYrHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MYHJcohq[mm2aX;uJI9nKGi3bXHuJG1QVFRvNDDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGuNFMzPDRizszN M16yb3NCVkeHUh?=
human D-283MED cell MVvHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NETaTWZKdmirYnn0bY9vKG:oIHj1cYFvKERvMkizUWVFKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OS5yM{m0PEDPpG1? NE\wXppUSU6JRWK=
human ALL-PO cell MVrHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MknDTY5pcWKrdHnvckBw\iCqdX3hckBCVExvUF:gZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlA3ODd|IN88US=> MXrTRW5ITVJ?
human NB14 cell MWrHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MnjwTY5pcWKrdHnvckBw\iCqdX3hckBPSjF2IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MT6wOlA5OSEQvF2= M373N3NCVkeHUh?=
human NTERA-S-cl-D1 cell NF7zdXJIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MUjJcohq[mm2aX;uJI9nKGi3bXHuJG5VTVKDLWOtZ4wuTDFiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1zLkC3O|c2KM7:TR?= M3fwdHNCVkeHUh?=
human BFTC-905 cell MVLHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NGW1fXRKdmirYnn0bY9vKG:oIHj1cYFvKEKIVFOtPVA2KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OS5yOEGwNUDPxE1? MmX4V2FPT0WU
human H4 cell M4qwd2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NIq1[3ZKdmirYnn0bY9vKG:oIHj1cYFvKEh2IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MT6xNFIxOSEQvF2= M3\IO3NCVkeHUh?=
human CHP-212 cell M2jwZ2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MUHJcohq[mm2aX;uJI9nKGi3bXHuJGNJWC1{MUKgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlE1ODN5IN88US=> M1PHW3NCVkeHUh?=
human A204 cell NX30dG5ST3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= Ml7hTY5pcWKrdHnvckBw\iCqdX3hckBCOjB2IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MT6xOVQ3PyEQvF2= NVnvVZcyW0GQR1XS
human NB69 cell MUXHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NF\FN4RKdmirYnn0bY9vKG:oIHj1cYFvKE6ENkmgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlE2QDZ3IN88US=> NGHWR|ZUSU6JRWK=
human P12-ICHIKAWA cell MVTHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NIDvW|lKdmirYnn0bY9vKG:oIHj1cYFvKFBzMj3JR2hKU0GZQTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGuNVgyPzFizszN NYHX[2dpW0GQR1XS
human L-363 cell NXn1OGFCT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M{\NcWlvcGmkaYTpc44hd2ZiaIXtZY4hVC1|NkOgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlE5OTl5IN88US=> M33HVXNCVkeHUh?=
human ES5 cell NFHyb5hIem:5dHigbY5pcWKrdHnvckBie3OjeR?= Mn3ZTY5pcWKrdHnvckBw\iCqdX3hckBGWzViY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1zLkG5N|U1KM7:TR?= MmfKV2FPT0WU
human CAL-51 cell NFjEXlZIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MoDxTY5pcWKrdHnvckBw\iCqdX3hckBESUxvNUGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlIzOTV4IN88US=> MmPzV2FPT0WU
human NBsusSR cell NFLNSGVIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MlfwTY5pcWKrdHnvckBw\iCqdX3hckBPSnO3c2PSJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU4zPDV5ODFOwG0> MmjnV2FPT0WU
human HOP-92 cell NXziTW5yT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MlroTY5pcWKrdHnvckBw\iCqdX3hckBJV1BvOUKgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlI4Ojl|IN88US=> Mn7LV2FPT0WU
human DU-4475 cell NXjERYd4T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= Ml[zTY5pcWKrdHnvckBw\iCqdX3hckBFXS12NEe1JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU4zQTJ2NTFOwG0> M3v5VHNCVkeHUh?=
human LB1047-RCC cell NYnlWI1CT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MYrJcohq[mm2aX;uJI9nKGi3bXHuJGxDOTB2Nz3SR2Mh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yNjJ7MkixJO69VQ>? NFnn[3pUSU6JRWK=
human D-566MG cell MVnHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MVfJcohq[mm2aX;uJI9nKGi3bXHuJGQuPTZ4TVegZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlMxPDR6IN88US=> M1\PNXNCVkeHUh?=
human A375 cell NG\V[JZIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MoftTY5pcWKrdHnvckBw\iCqdX3hckBCOzd3IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MT6zNFg2QCEQvF2= MkHkV2FPT0WU
human ATN-1 cell MYDHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NWjzXG9DUW6qaXLpeIlwdiCxZjDoeY1idiCDVF6tNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEvOzdzOEWg{txO NV7PO4MxW0GQR1XS
human M059J cell MYjHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MUHJcohq[mm2aX;uJI9nKGi3bXHuJG0xPTmMIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MT6zO|Y2OiEQvF2= MoHCV2FPT0WU
human HSC-3 cell MXrHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NVzqUHhSUW6qaXLpeIlwdiCxZjDoeY1idiCKU1OtN{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEvPDR{MEig{txO MlrmV2FPT0WU
human DOHH-2 cell Mlr5S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NUHZfXZJUW6qaXLpeIlwdiCxZjDoeY1idiCGT1jIMVIh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yNjR3OEG0JO69VQ>? MXvTRW5ITVJ?
human G-402 cell NWXveld{T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MlXkTY5pcWKrdHnvckBw\iCqdX3hckBINTRyMjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGuOFY2OjVizszN NGK0[2xUSU6JRWK=
human LC-2-ad cell NV;sdmR{T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= Ml3YTY5pcWKrdHnvckBw\iCqdX3hckBNSy1{LXHkJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU41PzF|MjFOwG0> NUWwNGg4W0GQR1XS
human LOXIMVI cell MkXoS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NVS2WYdpUW6qaXLpeIlwdiCxZjDoeY1idiCOT2jJUXZKKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OS53MEW1NkDPxE1? MYPTRW5ITVJ?
human DK-MG cell M3PTZ2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 Mor6TY5pcWKrdHnvckBw\iCqdX3hckBFUy2PRzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGuOVczQThizszN MVLTRW5ITVJ?
human HOS cell M4\tV2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MWjJcohq[mm2aX;uJI9nKGi3bXHuJGhQWyClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTFwNUezNFkh|ryP MUPTRW5ITVJ?
human BHT-101 cell MVrHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M37se2lvcGmkaYTpc44hd2ZiaIXtZY4hSkiWLUGwNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEvPTd6N{eg{txO M4\Uc3NCVkeHUh?=
human U-2-OS cell M363VGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MUfJcohq[mm2aX;uJI9nKGi3bXHuJHUuOi2RUzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGuOVg5ODZizszN MlfJV2FPT0WU
human D-423MG cell NVPiSXBMT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MmfkTY5pcWKrdHnvckBw\iCqdX3hckBFNTR{M13HJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU43ODhyNjFOwG0> NUDOWHdlW0GQR1XS
human AN3-CA cell NHi1OYVIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NYrsbo5YUW6qaXLpeIlwdiCxZjDoeY1idiCDTkOtR2Eh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yNjZ|OUmxJO69VQ>? MlXWV2FPT0WU
human TE-11 cell MVHHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MWnJcohq[mm2aX;uJI9nKGi3bXHuJHRGNTFzIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MT62OVI5KM7:TR?= MVjTRW5ITVJ?
human SK-NEP-1 cell MnfsS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MUjJcohq[mm2aX;uJI9nKGi3bXHuJHNMNU6HUD2xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU43PTN5NjFOwG0> NHX6Um1USU6JRWK=
human MG-63 cell NHLpNnJIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NYi4NVBXUW6qaXLpeIlwdiCxZjDoeY1idiCPRz22N{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEvPjh3Nkeg{txO NEi1c4VUSU6JRWK=
human RH-1 cell M2rBNWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NF\BN2hKdmirYnn0bY9vKG:oIHj1cYFvKFKKLUGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlcxOjd2IN88US=> MU\TRW5ITVJ?
human MDA-MB-157 cell M3u3eGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 Mo[zTY5pcWKrdHnvckBw\iCqdX3hckBOTEFvTVKtNVU4KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OS55MU[3OEDPxE1? M3vwU3NCVkeHUh?=
human A427 cell MVnHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? Mlz6TY5pcWKrdHnvckBw\iCqdX3hckBCPDJ5IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MT63N|U5QSEQvF2= NVPrToZvW0GQR1XS
human ES1 cell NVvocoxFT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M{fUdWlvcGmkaYTpc44hd2ZiaIXtZY4hTVNzIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MT63OVQ2OSEQvF2= MmHKV2FPT0WU
human C32 cell Ml:3S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M4rwXmlvcGmkaYTpc44hd2ZiaIXtZY4hSzN{IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MT63OlM6KM7:TR?= MV;TRW5ITVJ?
human LAMA-84 cell NEXDdnVIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NVjMTZp5UW6qaXLpeIlwdiCxZjDoeY1idiCOQV3BMVg1KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OS55Nki3NkDPxE1? M1XGenNCVkeHUh?=
human YKG-1 cell MYHHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? Mle4TY5pcWKrdHnvckBw\iCqdX3hckB[U0dvMTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGuO|cyOjRizszN M3XBe3NCVkeHUh?=
human NCI-H1048 cell NI[wXnBIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NWrGU2wxUW6qaXLpeIlwdiCxZjDoeY1idiCQQ1mtTFExPDhiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1zLke4OVA6KM7:TR?= Ml76V2FPT0WU
human KS-1 cell MVrHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MlvkTY5pcWKrdHnvckBw\iCqdX3hckBMWy1zIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MT64Nlk5KM7:TR?= NYH4cWdsW0GQR1XS
human JVM-3 cell MlLQS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MVrJcohq[mm2aX;uJI9nKGi3bXHuJGpXVS1|IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MT64OlQ6OSEQvF2= NUPHbmtxW0GQR1XS
human GI-ME-N cell MVLHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MXTJcohq[mm2aX;uJI9nKGi3bXHuJGdKNU2HLV6gZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlg3PTNizszN M3\idnNCVkeHUh?=
human GT3TKB cell M4nWcmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MY\Jcohq[mm2aX;uJI9nKGi3bXHuJGdVO1SNQjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGuPFk3PDJizszN M3v5bHNCVkeHUh?=
human CHL-1 cell MWLHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MV7Jcohq[mm2aX;uJI9nKGi3bXHuJGNJVC1zIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MT65NlM4QSEQvF2= NEfHZYtUSU6JRWK=
human CHP-134 cell M2ix[Gdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MljjTY5pcWKrdHnvckBw\iCqdX3hckBEUFBvMUO0JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU46PDR4NzFOwG0> MYPTRW5ITVJ?
human 8-MG-BA cell MXTHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M4\1U2lvcGmkaYTpc44hd2ZiaIXtZY4hQC2PRz3CRUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEvQTV5NESg{txO MoXrV2FPT0WU
human HO-1-N-1 cell NYrKbVB4T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M2PsNmlvcGmkaYTpc44hd2ZiaIXtZY4hUE9vMT3OMVEh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yNjl5MUG3JO69VQ>? NWjobFRvW0GQR1XS
human SW1088 cell NFX4cnVIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NF\IOmZKdmirYnn0bY9vKG:oIHj1cYFvKFOZMUC4PEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEvQTl4N{Og{txO M3;jNXNCVkeHUh?=
human SW48 cell NYfDOYRmT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NHPVWXdKdmirYnn0bY9vKG:oIHj1cYFvKFOZNEigZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yMlAzODZ5IN88US=> MlvjV2FPT0WU
human VM-CUB-1 cell M4Xj[2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 Moi5TY5pcWKrdHnvckBw\iCqdX3hckBXVS2FVVKtNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIvODRzMUmg{txO MlnVV2FPT0WU
human COLO-800 cell NEfXZXFIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MmC3TY5pcWKrdHnvckBw\iCqdX3hckBEV0yRLUiwNEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIvODVzM{[g{txO NH;jPWhUSU6JRWK=
human TI-73 cell MYLHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MnT0TY5pcWKrdHnvckBw\iCqdX3hckBVUS15MzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUKuNVE{QTlizszN M1LVWnNCVkeHUh?=
human HN cell NUK2TIFsT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NEDpTHdKdmirYnn0bY9vKG:oIHj1cYFvKEiQIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Mj6xNlE6QCEQvF2= MXrTRW5ITVJ?
human DB cell NH3KZXJIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NUP6T2dFUW6qaXLpeIlwdiCxZjDoeY1idiCGQjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUKuNVI3OzFizszN MoPMV2FPT0WU
human Ca9-22 cell NUD2SZVpT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NIPURWNKdmirYnn0bY9vKG:oIHj1cYFvKEOjOT2yNkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIvOTJ6NEeg{txO NYjRd5pvW0GQR1XS
human A549 cell MWHHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MkHzTY5pcWKrdHnvckBw\iCqdX3hckBCPTR7IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Mj6xN|gxQCEQvF2= NWi5UVQyW0GQR1XS
human KGN cell MlvHS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NVjBOZdIUW6qaXLpeIlwdiCxZjDoeY1idiCNR16gZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yMlIzPTl3IN88US=> NEPReppUSU6JRWK=
human BCPAP cell NYDDZYRZT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M4XQWmlvcGmkaYTpc44hd2ZiaIXtZY4hSkOSQWCgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yMlI{OTV6IN88US=> NV[zZ|ZRW0GQR1XS
human Ramos-2G6-4C10 cell MnPsS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NITuS2dKdmirYnn0bY9vKG:oIHj1cYFvKFKjbX;zMVJIPi12Q{GwJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Nk4zOzd3OTFOwG0> NWjq[HZEW0GQR1XS
human OVCAR-5 cell MUHHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MmXlTY5pcWKrdHnvckBw\iCqdX3hckBQXkODUj21JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Nk4zPzd|NDFOwG0> NIq1OFFUSU6JRWK=
human KG-1 cell MkjKS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NFzSemJKdmirYnn0bY9vKG:oIHj1cYFvKEuJLUGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yMlI4Pzl{IN88US=> NFXZfFhUSU6JRWK=
human CAKI-1 cell NXHiZYVWT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NXjodGxCUW6qaXLpeIlwdiCxZjDoeY1idiCFQVvJMVEh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0zNjJ6MEW4JO69VQ>? MmHmV2FPT0WU
human QIMR-WIL cell MYjHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NUnRUZhQUW6qaXLpeIlwdiCxZjDoeY1idiCTSV3SMXdKVCClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTJwMki3OFQh|ryP M4nhcHNCVkeHUh?=
human SW1710 cell M4nEcGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NYnSXJBFUW6qaXLpeIlwdiCxZjDoeY1idiCVV{G3NVAh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0zNjJ7MUSyJO69VQ>? MmPSV2FPT0WU
human SK-UT-1 cell MoexS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MYjJcohq[mm2aX;uJI9nKGi3bXHuJHNMNVWWLUGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yMlI6OzN7IN88US=> Mk\WV2FPT0WU
human IST-SL1 cell MmPFS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M4LGdGlvcGmkaYTpc44hd2ZiaIXtZY4hUVOWLWPMNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIvOzJzN{Sg{txO NV6yNmF6W0GQR1XS
human SW962 cell NHjMPItIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M1Gwd2lvcGmkaYTpc44hd2ZiaIXtZY4hW1d7NkKgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yMlM{PzV5IN88US=> MY\TRW5ITVJ?
human EM-2 cell MofGS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M2SxN2lvcGmkaYTpc44hd2ZiaIXtZY4hTU1vMjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUKuN|U{OzdizszN MXXTRW5ITVJ?
human D-263MG cell MX\Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M3e4VWlvcGmkaYTpc44hd2ZiaIXtZY4hTC1{NkPNS{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIvOzh|Mkeg{txO NEHUU3hUSU6JRWK=
human T98G cell MULHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NIDnc4xKdmirYnn0bY9vKG:oIHj1cYFvKFR7OFegZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yMlM5QDV5IN88US=> Ml3IV2FPT0WU
human CTB-1 cell M131eWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M4PhNGlvcGmkaYTpc44hd2ZiaIXtZY4hS1SELUGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yMlM6PzZzIN88US=> NXrGRVM2W0GQR1XS
human Hs-578-T cell NIDHbGJIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MoT2TY5pcWKrdHnvckBw\iCqdX3hckBJey13N{itWEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIvPDF3OEeg{txO M1v5N3NCVkeHUh?=
human SF126 cell NUnMToNOT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NIT6cZRKdmirYnn0bY9vKG:oIHj1cYFvKFOIMUK2JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Nk41OzZ{MTFOwG0> NXvqOlN{W0GQR1XS
human NCI-H460 cell MYDHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MoW5TY5pcWKrdHnvckBw\iCqdX3hckBPS0lvSES2NEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIvPDN7NUWg{txO MVfTRW5ITVJ?
human NCI-H1755 cell MV3Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NHvJeIlKdmirYnn0bY9vKG:oIHj1cYFvKE6FST3INVc2PSClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTJwNUSwOFMh|ryP M{m4cHNCVkeHUh?=
human HL-60 cell NFnmOWRIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M1rUOGlvcGmkaYTpc44hd2ZiaIXtZY4hUExvNkCgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yMlU1OTV7IN88US=> M4riXXNCVkeHUh?=
human G-401 cell MWfHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MkDMTY5pcWKrdHnvckBw\iCqdX3hckBINTRyMTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUKuOVYxQTlizszN NVLiVpo6W0GQR1XS
human AGS cell Mnu1S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MXzJcohq[mm2aX;uJI9nKGi3bXHuJGFIWyClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTJwNU[yOVch|ryP MoTXV2FPT0WU
human HuO9 cell NHr2c4pIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NXjWVo5lUW6qaXLpeIlwdiCxZjDoeY1idiCKdV:5JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Nk42PjR3NjFOwG0> NHm4WIhUSU6JRWK=
human MFE-280 cell NUG0[mhwT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NXThbmlMUW6qaXLpeIlwdiCxZjDoeY1idiCPRlWtNlgxKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:Oi53Nk[4OkDPxE1? NVTrVJBCW0GQR1XS
human NCI-H292 cell MYLHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M1LLTmlvcGmkaYTpc44hd2ZiaIXtZY4hVkOLLViyPVIh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0zNjV5N{KyJO69VQ>? MYDTRW5ITVJ?
human HuO-3N1 cell M{PhbWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MlzZTY5pcWKrdHnvckBw\iCqdX3hckBJfU9vM16xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Nk43ODNyNzFOwG0> NVT3[4ZHW0GQR1XS
human ES3 cell MlzaS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MnP5TY5pcWKrdHnvckBw\iCqdX3hckBGWzNiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1{Lk[yNlg2KM7:TR?= NULOeW1sW0GQR1XS
human LB2241-RCC cell NF;GfmRIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MXTJcohq[mm2aX;uJI9nKGi3bXHuJGxDOjJ2MT3SR2Mh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0zNjZ7MEe5JO69VQ>? NGPXNG9USU6JRWK=
human NCI-H1155 cell MXnHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? Ml7oTY5pcWKrdHnvckBw\iCqdX3hckBPS0lvSEGxOVUh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0zNjZ7NEC1JO69VQ>? MY\TRW5ITVJ?
human SW872 cell M1m5dmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NF;TOlNKdmirYnn0bY9vKG:oIHj1cYFvKFOZOEeyJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Nk44ODZ5NjFOwG0> Mmn3V2FPT0WU
human MHH-ES-1 cell NV6y[GJbT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MV;Jcohq[mm2aX;uJI9nKGi3bXHuJG1JUC2HUz2xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Nk44OjZ|MzFOwG0> MlnsV2FPT0WU
human KYSE-150 cell M3TPXGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M3H6UmlvcGmkaYTpc44hd2ZiaIXtZY4hU1mVRT2xOVAh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0zNjd{OUeg{txO NUj3XlFYW0GQR1XS
human MC-IXC cell M{L2[Wdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MkL5TY5pcWKrdHnvckBw\iCqdX3hckBOSy2LWFOgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yMlg6PTNizszN MkC5V2FPT0WU
human HCC1187 cell MVzHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M2HNd2lvcGmkaYTpc44hd2ZiaIXtZY4hUEOFMUG4O{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIvQDl4N{eg{txO NGjEWJpUSU6JRWK=
human UMC-11 cell M1LiXGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NHSwTVdKdmirYnn0bY9vKG:oIHj1cYFvKFWPQz2xNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIvQTB2N{eg{txO M{DIOHNCVkeHUh?=
human NB5 cell M1PROGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M17SbmlvcGmkaYTpc44hd2ZiaIXtZY4hVkJ3IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Mj65N|cyPSEQvF2= MVnTRW5ITVJ?
human A2058 cell MnvDS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MVzJcohq[mm2aX;uJI9nKGi3bXHuJGEzODV6IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Mj65O|g1PCEQvF2= NWfYRotpW0GQR1XS
human Becker cell MYrHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NETGVmlKdmirYnn0bY9vKG:oIHj1cYFvKEKnY3vldkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVMvODFzMUKg{txO NHG4NYZUSU6JRWK=
human CAS-1 cell MnTaS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MULJcohq[mm2aX;uJI9nKGi3bXHuJGNCWy1zIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Mz6wNVU3QSEQvF2= MXnTRW5ITVJ?
human SW780 cell M{DkPWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MUPJcohq[mm2aX;uJI9nKGi3bXHuJHNYPzhyIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Mz6yOVYxQSEQvF2= NILaepdUSU6JRWK=
human KM12 cell NUT5bno6T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MmrjTY5pcWKrdHnvckBw\iCqdX3hckBMVTF{IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Mz6zNFE{OiEQvF2= NVyyd|VQW0GQR1XS
human PC-3 cell MULHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NEjP[nJKdmirYnn0bY9vKG:oIHj1cYFvKFCFLUOgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME20MlE4PDFzIN88US=> Mn\6V2FPT0WU
human A253 cell MUPHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NH3sSmpKdmirYnn0bY9vKG:oIHj1cYFvKEF{NUOgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME20MlE5QDl|IN88US=> MmWxV2FPT0WU
human NB10 cell MmiwS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MojPTY5pcWKrdHnvckBw\iCqdX3hckBPSjFyIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;ND6yNlc4OyEQvF2= MVzTRW5ITVJ?
human A172 cell MU\Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MnT2TY5pcWKrdHnvckBw\iCqdX3hckBCOTd{IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;ND60OFU4KM7:TR?= MoO5V2FPT0WU
human A498 cell NX7BN5dvT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MoLJTY5pcWKrdHnvckBw\iCqdX3hckBCPDl6IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;ND61OlM5OyEQvF2= NG[3S5pUSU6JRWK=
human SW1573 cell NVGzbIFlT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NF\JUnJKdmirYnn0bY9vKG:oIHj1cYFvKFOZMUW3N{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVYvQTB2OUGg{txO NWfudnpVW0GQR1XS
human 5637 cell MUDHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M3vUVmlvcGmkaYTpc44hd2ZiaIXtZY4hPTZ|NzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUiuNFc6ODRizszN NX;6SXF5W0GQR1XS
human A388 cell MlvwS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MWjJcohq[mm2aX;uJI9nKGi3bXHuJGE{QDhiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1{MT6xN|k5KM7:TR?= M{fEc3NCVkeHUh?=
human U251 cell M4C1fGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MWrJcohq[mm2aX;uJI9nKGi3bXHuJHUzPTFiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1{OD6xNVc2KM7:TR?= MkHVV2FPT0WU

... Click to View More Cell Line Experimental Data

Protocol

Kinase Assay:[1]
+ Expand

Kinase assays:

PDK1 is assayed in a direct kinase assay and a coupled assay format measuring PDK1- and PtdIns-3,4-P2-mediated activation of AKT2. For the coupled assay, the final assay mixture (60 μL) contained: 15 mM MOPS, pH 7.2, 1 mg/mL bovine serum albumin, 18 mM β-glycerol phosphate, 0.7 mM dithiothreitol, 3 mM EGTA, 10 mM MgOAc, 7.5 μM ATP, 0.2 μCi of [γ-33P]ATP, 7.5 μM biotinylated peptide substrate (biotin-ARRRDGGGAQPFRPRAATF), 0.5 μL of PtdIns-3,4-P2-containing phospholipid vesicles, 60 pg of purified recombinant human PDK1, and 172 ng of purified recombinant human AKT2. After incubation for 2 h at room temperature, the biotin-labeled peptide is captured from 10 μl of the assay mixture on streptavidin-coated SPA beads, and product formation is measured by scintillation proximity in a Wallac MicroBeta counter. The product formed is proportional to the time of incubation and to the amount of PDK1 and inactive AKT2 added. PDK1 is added at suboptimal levels so that the assay could sensitively detect inhibitors of AKT2 activation as well as direct inhibitors of PDK1 or AKT2. To measure PDK1 activity directly, the final assay mixture (60 μL) contained 50 mM Tris-HCl, pH 7.5, 0.1 mM EGTA, 0.1 mM EDTA, 0.1% β-mercaptoethanol, 1 mg/mL bovine serum albumin, 10 mM MgOAc, 10 μM ATP, 0.2 μCi of [γ-33P]ATP, 7.5 μM substrate peptide (H2N-ARRRGVTTKTFCGT), and 60 ng of purified recombinant human PDK1. After 4 h at room temperature, we add 25 mM EDTA and spotted a portion of the reaction mixture on Whatman P81 phosphocellulose paper. The filter paper is washed three times with 0.75% phosphoric acid and once with acetone. After drying, the filter-bound labeled peptide is quantified using a Fuji phosphorimager.
Cell Research:[1]
+ Expand
  • Cell lines: MDA-468, PC-3, HCT-116 and MiaPaca cells
  • Concentrations: ~10 μM
  • Incubation Time: 72 hours
  • Method: Cells seeded at a low density (1,500–3,000 cells/well, 0.1 mL/well, 96-well plates) are incubated overnight. Compound treatments are made by adding 10 μL/well of the compound in 1% dimethyl sulfoxide and growth medium (final concentration of dimethyl sulfoxide, 0.1%), followed by brief shaking. Treated cells are incubated for 72 hours, and viability is measured by the addition of 10 μL of the metabolic dye WST-1. The WST-1 signal is read in a plate reader at 450 nm, and a no cell, or zero time cell, background is subtracted to calculate the net signal. Results are reported as the average ± S.E. of two or more replicates.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 100 mg/mL (169.07 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents individually and in order:
30% PEG400+0.5% Tween80+5% propylene glycol
30 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 591.47
Formula

C23H26IN7O2S

CAS No. 702675-74-9
Storage powder
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

  • Mass
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    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
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    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

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PDK Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID