BX-795

Catalog No.S1274

BX-795 Chemical Structure

Molecular Weight(MW): 591.47

BX795 is a potent and specific PDK1 inhibitor with IC50 of 6 nM, 140- and 1600-fold more selective for PDK1 than PKA and PKC in cell-free assays, respectively. Meanwhile, in comparison to GSK3β more than 100-fold selectivity observed for PDK1.

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3 Customer Reviews

  • Induction of basal p62 Ser403 phosphorylation in ULK1/2-deficient MEF was suppressed by BX-795, an inhibitor of TBK1. WT ( Ulk1 +/+/Ulk2 +/+) and Ulk1 -/- /Ulk2 -/-(KO) MEF were treated with NaCl/Pi (Con) or 10 uM BX-795 for 6 h, and subjected to immunoblotting with indicated antibodies.

    FEBS J 2014 281(17), 3816-27. BX-795 purchased from Selleck.

    Virology 2014 450-451, 182-95. BX-795 purchased from Selleck.

  • Western blot analysis of pPRAS40 (T246), pS6 (S240/S244), and pS6 (S235/S236) proteins in (A) HeyA8 cells and (B) SKOV3 cells treated with 3.33 μM or 10 μM inhibitors (BX795 or CCT128930) in three-dimensional cell culture for 24 hours. Ten percent fetal bovine serum was used in A and B.

    PLoS One, 2016, 11(5):e0155052. . BX-795 purchased from Selleck.

Purity & Quality Control

Choose Selective PDK Inhibitors

Biological Activity

Description BX795 is a potent and specific PDK1 inhibitor with IC50 of 6 nM, 140- and 1600-fold more selective for PDK1 than PKA and PKC in cell-free assays, respectively. Meanwhile, in comparison to GSK3β more than 100-fold selectivity observed for PDK1.
Targets
PDK-1 [1]
(Cell-free assay)
c-Kit [1]
(Cell-free assay)
CDK2/CyclinE [1]
(Cell-free assay)
Chk1 [1]
(Cell-free assay)
6 nM 320 nM 430 nM 510 nM
In vitro

BX-795 effectively blocks PDK1 activity in PC-3 cells, as shown by their ability to block phosphorylation of S6K1, Akt, PKCδ, and GSK3β. BX-795 potently inhibits tumor cell growth on plastic with IC50 of 1.6, 1.4, and 1.9 μM for MDA-468, HCT-116 and MiaPaca cells, respectively. In soft agar, BX-795 displays higher growth inhibition with IC50 of 0.72, and 0.25 μM for MDA-468, and PC-3 cells, respectively. [1] In addition, BX-795, as an inhibitor of the TBK1/IKKɛ, blocks TBK1- and IKKε-mediated activation of IRF3 and production of IFN-β. [2] In platelet physiological responses, BX795 produces inhibitory effect on 2-MeSADP-induced or collagen-induced aggregation, ATP secretion and thromboxane generation. [3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
human MV-4-11 cell MVTHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MlK3TY5pcWKrdHnvckBw\iCqdX3hckBOXi12LUGxJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9N|YvQCCwTR?= M32zR3NCVkeHUh?=
KRX cells NI\oOmRHfW6ldHnvckBie3OjeR?= M1juW|chdWmwcx?= MX\Jcohq[mm2aX;uJI9nKFOXTV:teIFo\2WmIGXMT|EhMHWwa37ve44hd3KrZ3nuLUBscW6jc3Wg[I9u[WmwIHX4dJJme3OnZDDpckBMWlhiY3XscJMhfXOrbnegX|MzWF1vZ3HtcYEuSVSSIHHu[EBugWWuaX6gZoF{cWNicILveIVqdiC|dXLzeJJifGViaX7jeYJifGWmIH\vdkA4KG2rboO= MYiyOlI4PTZ6MR?=
human NKM-1 cell NFvhU49Iem:5dHigbY5pcWKrdHnvckBie3OjeR?= M4TZ[mlvcGmkaYTpc44hd2ZiaIXtZY4hVkuPLUGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2wMlM3OTl2IN88US=> NEn4WolUSU6JRWK=
human P30-OHK cell NI\QS4RIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M2P5fGlvcGmkaYTpc44hd2ZiaIXtZY4hWDNyLV;IT{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7LDDJR|UxRTBwNEm2OUDPxE1? M{Oz[nNCVkeHUh?=
human YH-13 cell M2rvO2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NE\WTItKdmirYnn0bY9vKG:oIHj1cYFvKFmKLUGzJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NE43Ojh6ODFOwG0> Mm\TV2FPT0WU
human LXF-289 cell NHm0cGlIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NUfobYZjUW6qaXLpeIlwdiCxZjDoeY1idiCOWF[tNlg6KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XlwIFnDOVA:OC54NU[5N{DPxE1? M2\oenNCVkeHUh?=
human BE-13 cell NX;qdoRuT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NWfOb4FvUW6qaXLpeIlwdiCxZjDoeY1idiCERT2xN{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVAvPzB2N{eg{txO MVzTRW5ITVJ?
human RS4-11 cell MmHJS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NFTHZoZKdmirYnn0bY9vKG:oIHj1cYFvKFKVND2xNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVAvPzJ3OUSg{txO MYHTRW5ITVJ?
human A3-KAW cell NYnne3VvT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M1H3[WlvcGmkaYTpc44hd2ZiaIXtZY4hSTNvS1HXJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NE44OzB3NTFOwG0> M3rsVnNCVkeHUh?=
human PA-1 cell NH;pOZBIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NGrP[ZJKdmirYnn0bY9vKG:oIHj1cYFvKFCDLUGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2wMlgxPDJ{IN88US=> MnWzV2FPT0WU
human ES7 cell MnTGS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NXXBRXNZUW6qaXLpeIlwdiCxZjDoeY1idiCHU{egZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2wMlg{PTZ4IN88US=> NEDVSVhUSU6JRWK=
human ES8 cell MmfUS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MlXQTY5pcWKrdHnvckBw\iCqdX3hckBGWzhiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1yLki0N|M3KM7:TR?= MmjZV2FPT0WU
human SW982 cell MWfHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NIXIfWhKdmirYnn0bY9vKG:oIHj1cYFvKFOZOUiyJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NE46PTF{NDFOwG0> M1LuXHNCVkeHUh?=
human VA-ES-BJ cell MkPwS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MXfJcohq[mm2aX;uJI9nKGi3bXHuJHZCNUWVLVLKJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NE46QDR4NzFOwG0> Mm[4V2FPT0WU
human 697 cell NGDFdXRIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M2HhSWlvcGmkaYTpc44hd2ZiaIXtZY4hPjl5IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MT6wNVYzOyEQvF2= NG[4NFlUSU6JRWK=
human MOLT-4 cell M4\pcWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M{D6emlvcGmkaYTpc44hd2ZiaIXtZY4hVU:OVD20JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU4xOzJ2NDFOwG0> Mn71V2FPT0WU
human D-283MED cell M1\4cmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MX\Jcohq[mm2aX;uJI9nKGi3bXHuJGQuOjh|TVXEJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU4xOzl2ODFOoI0> Ml;IV2FPT0WU
human ALL-PO cell MlvoS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NXrvbYdnUW6qaXLpeIlwdiCxZjDoeY1idiCDTFytVG8h[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yNjB4MEezJO69VQ>? M{K3ZnNCVkeHUh?=
human NB14 cell MUnHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M{Pr[2lvcGmkaYTpc44hd2ZiaIXtZY4hVkJzNDDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGuNFYxQDFizszN MkjvV2FPT0WU
human NTERA-S-cl-D1 cell MVHHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NX[4[2xYUW6qaXLpeIlwdiCxZjDoeY1idiCQVFXSRU1UNWOuLVSxJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU4xPzd5NTFOwG0> MWjTRW5ITVJ?
human BFTC-905 cell NEDPSopIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MUXJcohq[mm2aX;uJI9nKGi3bXHuJGJHXENvOUC1JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU4xQDFyMTFOwG0> NFXNO4lUSU6JRWK=
human H4 cell NHLyOFVIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MkHoTY5pcWKrdHnvckBw\iCqdX3hckBJPCClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTFwMUCyNFEh|ryP NFztNVNUSU6JRWK=
human CHP-212 cell MlXtS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NYPwd41HUW6qaXLpeIlwdiCxZjDoeY1idiCFSGCtNlEzKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OS5zNECzO{DPxE1? Mo\WV2FPT0WU
human A204 cell NWLSTXBuT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MnW4TY5pcWKrdHnvckBw\iCqdX3hckBCOjB2IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MT6xOVQ3PyEQvF2= MorHV2FPT0WU
human NB69 cell NUW1dJNDT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NWThRWV7UW6qaXLpeIlwdiCxZjDoeY1idiCQQk[5JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU4yPTh4NTFOwG0> NI\XfHhUSU6JRWK=
human P12-ICHIKAWA cell NUTaUnpGT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MnLNTY5pcWKrdHnvckBw\iCqdX3hckBROTJvSVPITWtCX0FiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1zLkG4NVcyKM7:TR?= MknCV2FPT0WU
human L-363 cell M3f4NGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MYjJcohq[mm2aX;uJI9nKGi3bXHuJGwuOzZ|IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MT6xPFE6PyEQvF2= M1j0bHNCVkeHUh?=
human ES5 cell M{fKN2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NUe5c4lpUW6qaXLpeIlwdiCxZjDoeY1idiCHU{WgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlE6OzV2IN88US=> NHf3SoJUSU6JRWK=
human CAL-51 cell NIf4cYxIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M1TWdGlvcGmkaYTpc44hd2ZiaIXtZY4hS0GOLUWxJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU4zOjF3NjFOwG0> M{LZfnNCVkeHUh?=
human NBsusSR cell NF3HcldIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MlruTY5pcWKrdHnvckBw\iCqdX3hckBPSnO3c2PSJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU4zPDV5ODFOwG0> M3vBXXNCVkeHUh?=
human HOP-92 cell MlvPS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M1[5SGlvcGmkaYTpc44hd2ZiaIXtZY4hUE:SLUmyJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU4zPzJ7MzFOwG0> MUfTRW5ITVJ?
human DU-4475 cell NWrX[Ys4T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NVfnOYwyUW6qaXLpeIlwdiCxZjDoeY1idiCGVT20OFc2KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OS5{OUK0OUDPxE1? NGL6elZUSU6JRWK=
human LB1047-RCC cell NUO3bm1sT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NVXzOWVGUW6qaXLpeIlwdiCxZjDoeY1idiCOQkGwOFcuWkOFIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MT6yPVI5OSEQvF2= M2rnWnNCVkeHUh?=
human D-566MG cell MV3Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NHzLe25KdmirYnn0bY9vKG:oIHj1cYFvKERvNU[2UWch[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yNjNyNES4JO69VQ>? NVPuNnJYW0GQR1XS
human A375 cell MmTxS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MlTCTY5pcWKrdHnvckBw\iCqdX3hckBCOzd3IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MT6zNFg2QCEQvF2= NFvOXppUSU6JRWK=
human ATN-1 cell MUnHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? Mnn6TY5pcWKrdHnvckBw\iCqdX3hckBCXE5vMTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGuN|cyQDVizszN MYHTRW5ITVJ?
human M059J cell Mlv2S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MYHJcohq[mm2aX;uJI9nKGi3bXHuJG0xPTmMIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MT6zO|Y2OiEQvF2= Mnj6V2FPT0WU
human HSC-3 cell MUjHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? Ml3QTY5pcWKrdHnvckBw\iCqdX3hckBJW0NvMzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGuOFQzODhizszN MU\TRW5ITVJ?
human DOHH-2 cell NHL6d5NIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NXmzRnlWUW6qaXLpeIlwdiCxZjDoeY1idiCGT1jIMVIh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yNjR3OEG0JO69VQ>? NH74TmZUSU6JRWK=
human G-402 cell NHvud2xIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MXPJcohq[mm2aX;uJI9nKGi3bXHuJGcuPDB{IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MT60OlUzPSEQvF2= NGPXS|FUSU6JRWK=
human LC-2-ad cell MlfNS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NXv6PGlvUW6qaXLpeIlwdiCxZjDoeY1idiCOQz2yMYFlKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OS52N{GzNkDPxE1? MYTTRW5ITVJ?
human LOXIMVI cell Mn62S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NF3FeFZKdmirYnn0bY9vKG:oIHj1cYFvKEyRWFnNWmkh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yNjVyNUWyJO69VQ>? NGfDR4NUSU6JRWK=
human DK-MG cell M4f6[Gdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NFPzR|ZKdmirYnn0bY9vKG:oIHj1cYFvKESNLV3HJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU42PzJ7ODFOwG0> NFzYVFZUSU6JRWK=
human HOS cell MmfoS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NUnKbJZIUW6qaXLpeIlwdiCxZjDoeY1idiCKT2OgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlU4OzB7IN88US=> M2DObXNCVkeHUh?=
human BHT-101 cell M2LLOWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MUfJcohq[mm2aX;uJI9nKGi3bXHuJGJJXC1zMEGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlU4QDd5IN88US=> M{HVcXNCVkeHUh?=
human U-2-OS cell MkjaS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MoTuTY5pcWKrdHnvckBw\iCqdX3hckBWNTJvT2OgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlU5QDB4IN88US=> NIjrbW5USU6JRWK=
human D-423MG cell M4fwXGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MnrLTY5pcWKrdHnvckBw\iCqdX3hckBFNTR{M13HJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU43ODhyNjFOwG0> MmnNV2FPT0WU
human AN3-CA cell MWrHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NGLCT|dKdmirYnn0bY9vKG:oIHj1cYFvKEGQMz3DRUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEvPjN7OUGg{txO M2nofnNCVkeHUh?=
human TE-11 cell NELSTXhIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NILzUVRKdmirYnn0bY9vKG:oIHj1cYFvKFSHLUGxJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU43PTJ6IN88US=> Mk\lV2FPT0WU
human SK-NEP-1 cell NGjlcnpIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NHX0c3JKdmirYnn0bY9vKG:oIHj1cYFvKFONLV7FVE0yKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OS54NUO3OkDPxE1? NUPObmJpW0GQR1XS
human MG-63 cell NXzoPWhQT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NWS5WXpqUW6qaXLpeIlwdiCxZjDoeY1idiCPRz22N{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEvPjh3Nkeg{txO M3j4fHNCVkeHUh?=
human RH-1 cell NF;BbJpIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NW\BWFdEUW6qaXLpeIlwdiCxZjDoeY1idiCUSD2xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU44ODJ5NDFOwG0> M1\FdHNCVkeHUh?=
human MDA-MB-157 cell NITmT5JIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M1;NVWlvcGmkaYTpc44hd2ZiaIXtZY4hVUSDLV3CMVE2PyClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTFwN{G2O|Qh|ryP MnnBV2FPT0WU
human A427 cell MYLHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MWjJcohq[mm2aX;uJI9nKGi3bXHuJGE1OjdiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1zLkezOVg6KM7:TR?= MVHTRW5ITVJ?
human ES1 cell MXzHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M{XZSmlvcGmkaYTpc44hd2ZiaIXtZY4hTVNzIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MT63OVQ2OSEQvF2= M2LMd3NCVkeHUh?=
human C32 cell NUH1eZZVT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MWPJcohq[mm2aX;uJI9nKGi3bXHuJGM{OiClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTFwN{[zPUDPxE1? NWLvRm1{W0GQR1XS
human LAMA-84 cell NVH2SllzT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NV;BUo1KUW6qaXLpeIlwdiCxZjDoeY1idiCOQV3BMVg1KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OS55Nki3NkDPxE1? MWTTRW5ITVJ?
human YKG-1 cell NYm2emZuT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MVLJcohq[mm2aX;uJI9nKGi3bXHuJHlMTy1zIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MT63O|EzPCEQvF2= M2OyUXNCVkeHUh?=
human NCI-H1048 cell M{LUOWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NY\jWIJPUW6qaXLpeIlwdiCxZjDoeY1idiCQQ1mtTFExPDhiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1zLke4OVA6KM7:TR?= NUfLbGJyW0GQR1XS
human KS-1 cell NETafZVIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MX;Jcohq[mm2aX;uJI9nKGi3bXHuJGtUNTFiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1zLkiyPVgh|ryP MnrPV2FPT0WU
human JVM-3 cell MXXHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MYTJcohq[mm2aX;uJI9nKGi3bXHuJGpXVS1|IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MT64OlQ6OSEQvF2= NYraTZB[W0GQR1XS
human GI-ME-N cell NFzhN3ZIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NUnoc|VxUW6qaXLpeIlwdiCxZjDoeY1idiCJST3NSU1PKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OS56NkWzJO69VQ>? M1[wPXNCVkeHUh?=
human GT3TKB cell M4TyOWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M{PLU2lvcGmkaYTpc44hd2ZiaIXtZY4hT1R|VFvCJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU45QTZ2MjFOwG0> MXvTRW5ITVJ?
human CHL-1 cell MYPHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MknETY5pcWKrdHnvckBw\iCqdX3hckBEUExvMTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGuPVI{PzlizszN MoPpV2FPT0WU
human CHP-134 cell NFXldFRIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MX;Jcohq[mm2aX;uJI9nKGi3bXHuJGNJWC1zM{SgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlk1PDZ5IN88US=> NEWzVW9USU6JRWK=
human 8-MG-BA cell NEXKephIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NHzsTmVKdmirYnn0bY9vKG:oIHj1cYFvKDhvTVetRmEh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yNjl3N{S0JO69VQ>? NXzoRplnW0GQR1XS
human HO-1-N-1 cell MnTjS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NWPqR2Y1UW6qaXLpeIlwdiCxZjDoeY1idiCKTz2xMW4uOSClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTFwOUexNVch|ryP NIPGdWtUSU6JRWK=
human SW1088 cell NH3iTJJIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NGTtW3lKdmirYnn0bY9vKG:oIHj1cYFvKFOZMUC4PEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEvQTl4N{Og{txO M2[wTHNCVkeHUh?=
human SW48 cell NHPFRmZIem:5dHigbY5pcWKrdHnvckBie3OjeR?= Mn7HTY5pcWKrdHnvckBw\iCqdX3hckBUXzR6IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Mj6wNlA3PyEQvF2= M1\4SHNCVkeHUh?=
human VM-CUB-1 cell M{\ZU2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 Mk\ETY5pcWKrdHnvckBw\iCqdX3hckBXVS2FVVKtNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIvODRzMUmg{txO MkLoV2FPT0WU
human COLO-800 cell NWWzXHJNT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NH:5[XNKdmirYnn0bY9vKG:oIHj1cYFvKEORTF:tPFAxKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:Oi5yNUGzOkDPxE1? M2XKTXNCVkeHUh?=
human TI-73 cell MlG4S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NGTwNpBKdmirYnn0bY9vKG:oIHj1cYFvKFSLLUezJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Nk4yOTN7OTFOwG0> MUfTRW5ITVJ?
human HN cell NYP1UWp6T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MlTDTY5pcWKrdHnvckBw\iCqdX3hckBJViClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTJwMUKxPVgh|ryP MWrTRW5ITVJ?
human DB cell MoHES5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MnLhTY5pcWKrdHnvckBw\iCqdX3hckBFSiClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTJwMUK2N|Eh|ryP NGDRPWZUSU6JRWK=
human Ca9-22 cell NVLNUY9YT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MoPVTY5pcWKrdHnvckBw\iCqdX3hckBE[TlvMkKgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yMlEzQDR5IN88US=> M{PaPHNCVkeHUh?=
human A549 cell NVvxZmU1T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M3rJemlvcGmkaYTpc44hd2ZiaIXtZY4hSTV2OTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUKuNVM5ODhizszN MoDOV2FPT0WU
human KGN cell NX36PZE4T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NWfPfoZzUW6qaXLpeIlwdiCxZjDoeY1idiCNR16gZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yMlIzPTl3IN88US=> NUXjcnB7W0GQR1XS
human BCPAP cell M3;0UWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 Mm[3TY5pcWKrdHnvckBw\iCqdX3hckBDS1CDUDDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUKuNlMyPThizszN NWHJPHYxW0GQR1XS
human Ramos-2G6-4C10 cell Mo[xS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M3\HfmlvcGmkaYTpc44hd2ZiaIXtZY4hWmGvb4OtNmc3NTSFMUCgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yMlI{PzV7IN88US=> M4KyNnNCVkeHUh?=
human OVCAR-5 cell NGfXfZlIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MoDUTY5pcWKrdHnvckBw\iCqdX3hckBQXkODUj21JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Nk4zPzd|NDFOwG0> MVzTRW5ITVJ?
human KG-1 cell NYLHenE2T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M2ftN2lvcGmkaYTpc44hd2ZiaIXtZY4hU0dvMTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUKuNlc4QTJizszN M3nZNHNCVkeHUh?=
human CAKI-1 cell M{izcGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MXrJcohq[mm2aX;uJI9nKGi3bXHuJGNCU0lvMTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUKuNlgxPThizszN MXXTRW5ITVJ?
human QIMR-WIL cell MULHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NITCV2lKdmirYnn0bY9vKG:oIHj1cYFvKFGLTWKtW2lNKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:Oi5{OEe0OEDPxE1? NFvFRWxUSU6JRWK=
human SW1710 cell MYLHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M2TDUGlvcGmkaYTpc44hd2ZiaIXtZY4hW1dzN{GwJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Nk4zQTF2MjFOwG0> MmX1V2FPT0WU
human SK-UT-1 cell NUW0NWpkT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MYjJcohq[mm2aX;uJI9nKGi3bXHuJHNMNVWWLUGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yMlI6OzN7IN88US=> NIT3TJRUSU6JRWK=
human IST-SL1 cell NX\sWYJWT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NWjLPG9qUW6qaXLpeIlwdiCxZjDoeY1idiCLU2StV2wyKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:Oi5|MkG3OEDPxE1? NVWxdYJKW0GQR1XS
human SW962 cell MVvHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NInNU4dKdmirYnn0bY9vKG:oIHj1cYFvKFOZOU[yJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Nk4{Ozd3NzFOwG0> NF62b3NUSU6JRWK=
human EM-2 cell NH7QdpNIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NYTQ[2dXUW6qaXLpeIlwdiCxZjDoeY1idiCHTT2yJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Nk4{PTN|NzFOwG0> MmPaV2FPT0WU
human D-263MG cell M{nub2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M{Hkb2lvcGmkaYTpc44hd2ZiaIXtZY4hTC1{NkPNS{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIvOzh|Mkeg{txO M2TKNHNCVkeHUh?=
human T98G cell NFnFPHhIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MXfJcohq[mm2aX;uJI9nKGi3bXHuJHQ6QEdiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1{LkO4PFU4KM7:TR?= MX3TRW5ITVJ?
human CTB-1 cell NF\FU4hIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MVzJcohq[mm2aX;uJI9nKGi3bXHuJGNVSi1zIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Mj6zPVc3OSEQvF2= MUDTRW5ITVJ?
human Hs-578-T cell MYrHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NYe0[21{UW6qaXLpeIlwdiCxZjDoeY1idiCKcz21O|guXCClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTJwNEG1PFch|ryP M{TNfnNCVkeHUh?=
human SF126 cell MWnHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MW\Jcohq[mm2aX;uJI9nKGi3bXHuJHNHOTJ4IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Mj60N|YzOSEQvF2= NV;MTnR5W0GQR1XS
human NCI-H460 cell NYfn[JYyT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M1zJOWlvcGmkaYTpc44hd2ZiaIXtZY4hVkOLLVi0OlAh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0zNjR|OUW1JO69VQ>? NYnvbm1oW0GQR1XS
human NCI-H1755 cell NXGxTGF7T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MUXJcohq[mm2aX;uJI9nKGi3bXHuJG5EUS2KMUe1OUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIvPTRyNEOg{txO NX;mdG1NW0GQR1XS
human HL-60 cell MofTS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M2jteGlvcGmkaYTpc44hd2ZiaIXtZY4hUExvNkCgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yMlU1OTV7IN88US=> MkTUV2FPT0WU
human G-401 cell M2fCeWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M2WwfWlvcGmkaYTpc44hd2ZiaIXtZY4hTy12MEGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yMlU3ODl7IN88US=> M4WzdXNCVkeHUh?=
human AGS cell MkfMS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M2e5NWlvcGmkaYTpc44hd2ZiaIXtZY4hSUeVIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Mj61OlI2PyEQvF2= NF;0c3lUSU6JRWK=
human HuO9 cell M3PpOWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M4\ubGlvcGmkaYTpc44hd2ZiaIXtZY4hUHWROTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUKuOVY1PTZizszN NVvtXIdxW0GQR1XS
human MFE-280 cell M1TETGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M4fyfGlvcGmkaYTpc44hd2ZiaIXtZY4hVU[HLUK4NEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIvPTZ4OE[g{txO M3qwTXNCVkeHUh?=
human NCI-H292 cell M3vsNWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M37NbGlvcGmkaYTpc44hd2ZiaIXtZY4hVkOLLViyPVIh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0zNjV5N{KyJO69VQ>? MUTTRW5ITVJ?
human HuO-3N1 cell MYXHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M1\DXWlvcGmkaYTpc44hd2ZiaIXtZY4hUHWRLUPONUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIvPjB|MEeg{txO MUjTRW5ITVJ?
human ES3 cell NYjPN29oT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NXzac2JWUW6qaXLpeIlwdiCxZjDoeY1idiCHU{OgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yMlYzOjh3IN88US=> Mm\uV2FPT0WU
human LB2241-RCC cell NVTJO2ZMT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NITyWJpKdmirYnn0bY9vKG:oIHj1cYFvKEyEMkK0NU1TS0NiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1{Lk[5NFc6KM7:TR?= MmPlV2FPT0WU
human NCI-H1155 cell MV;Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M3i4NGlvcGmkaYTpc44hd2ZiaIXtZY4hVkOLLVixNVU2KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:Oi54OUSwOUDPxE1? NX;PVW17W0GQR1XS
human SW872 cell M4DD[mdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NWG4cHV[UW6qaXLpeIlwdiCxZjDoeY1idiCVV{i3NkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIvPzB4N{[g{txO MYnTRW5ITVJ?
human MHH-ES-1 cell NXHQUXZxT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MWDJcohq[mm2aX;uJI9nKGi3bXHuJG1JUC2HUz2xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Nk44OjZ|MzFOwG0> MX;TRW5ITVJ?
human KYSE-150 cell MWjHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NUT4VGVKUW6qaXLpeIlwdiCxZjDoeY1idiCNWWPFMVE2OCClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTJwN{K5O{DPxE1? MV\TRW5ITVJ?
human MC-IXC cell NYO0dYlNT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M1z1VGlvcGmkaYTpc44hd2ZiaIXtZY4hVUNvSWjDJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Nk45QTV|IN88US=> M3ny[XNCVkeHUh?=
human HCC1187 cell MYjHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MYrJcohq[mm2aX;uJI9nKGi3bXHuJGhESzFzOEegZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yMlg6Pjd5IN88US=> NUHKfphnW0GQR1XS
human UMC-11 cell MWfHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NXXJcok2UW6qaXLpeIlwdiCxZjDoeY1idiCXTVOtNVEh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0zNjlyNEe3JO69VQ>? NUPXTYsyW0GQR1XS
human NB5 cell NIL2eolIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NFjqVmhKdmirYnn0bY9vKG:oIHj1cYFvKE6ENTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUKuPVM4OTVizszN NHzuOXJUSU6JRWK=
human A2058 cell MlixS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NFvNfmtKdmirYnn0bY9vKG:oIHj1cYFvKEF{MEW4JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Nk46Pzh2NDFOwG0> NET6e2hUSU6JRWK=
human Becker cell NXv0bGc{T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NWqzTmdkUW6qaXLpeIlwdiCxZjDoeY1idiCEZXPr[ZIh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0{NjBzMUGyJO69VQ>? MoLxV2FPT0WU
human CAS-1 cell NHW0U|lIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MlO2TY5pcWKrdHnvckBw\iCqdX3hckBESVNvMTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUOuNFE2PjlizszN NV\mbGd[W0GQR1XS
human SW780 cell NF\jbHlIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M4\VXGlvcGmkaYTpc44hd2ZiaIXtZY4hW1d5OECgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2zMlI2PjB7IN88US=> MnHkV2FPT0WU
human KM12 cell MnTrS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MUDJcohq[mm2aX;uJI9nKGi3bXHuJGtOOTJiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1|LkOwNVMzKM7:TR?= NYLHTlVrW0GQR1XS
human PC-3 cell NFjTWVFIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NUCzOZZvUW6qaXLpeIlwdiCxZjDoeY1idiCSQz2zJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9OE4yPzRzMTFOwG0> MVPTRW5ITVJ?
human A253 cell MnPrS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NV23do5uUW6qaXLpeIlwdiCxZjDoeY1idiCDMkWzJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9OE4yQDh7MzFOwG0> M1rHcnNCVkeHUh?=
human NB10 cell Moj4S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NYrkenZ[UW6qaXLpeIlwdiCxZjDoeY1idiCQQkGwJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9OE4zOjd5MzFOwG0> MkK4V2FPT0WU
human A172 cell NY[5fHNET3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M4n6dGlvcGmkaYTpc44hd2ZiaIXtZY4hSTF5MjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUSuOFQ2PyEQvF2= Ml\LV2FPT0WU
human A498 cell NVTN[GNWT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MluzTY5pcWKrdHnvckBw\iCqdX3hckBCPDl6IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;ND61OlM5OyEQvF2= M1nMRnNCVkeHUh?=
human SW1573 cell MkX3S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MYnJcohq[mm2aX;uJI9nKGi3bXHuJHNYOTV5MzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPU[uPVA1QTFizszN MoGyV2FPT0WU
human 5637 cell MlfIS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NF7EfZlKdmirYnn0bY9vKG:oIHj1cYFvKDV4M{egZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME24MlA4QTB2IN88US=> M4DVfHNCVkeHUh?=
human A388 cell NXPCZWI{T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NHTOcFlKdmirYnn0bY9vKG:oIHj1cYFvKEF|OEigZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yNU4yOzl6IN88US=> NWLm[XN6W0GQR1XS
human U251 cell MnXRS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NI[wXJdKdmirYnn0bY9vKG:oIHj1cYFvKFV{NUGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yPE4yOTd3IN88US=> MX3TRW5ITVJ?

... Click to View More Cell Line Experimental Data

Protocol

Kinase Assay:[1]
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Kinase assays:

PDK1 is assayed in a direct kinase assay and a coupled assay format measuring PDK1- and PtdIns-3,4-P2-mediated activation of AKT2. For the coupled assay, the final assay mixture (60 μL) contained: 15 mM MOPS, pH 7.2, 1 mg/mL bovine serum albumin, 18 mM β-glycerol phosphate, 0.7 mM dithiothreitol, 3 mM EGTA, 10 mM MgOAc, 7.5 μM ATP, 0.2 μCi of [γ-33P]ATP, 7.5 μM biotinylated peptide substrate (biotin-ARRRDGGGAQPFRPRAATF), 0.5 μL of PtdIns-3,4-P2-containing phospholipid vesicles, 60 pg of purified recombinant human PDK1, and 172 ng of purified recombinant human AKT2. After incubation for 2 h at room temperature, the biotin-labeled peptide is captured from 10 μl of the assay mixture on streptavidin-coated SPA beads, and product formation is measured by scintillation proximity in a Wallac MicroBeta counter. The product formed is proportional to the time of incubation and to the amount of PDK1 and inactive AKT2 added. PDK1 is added at suboptimal levels so that the assay could sensitively detect inhibitors of AKT2 activation as well as direct inhibitors of PDK1 or AKT2. To measure PDK1 activity directly, the final assay mixture (60 μL) contained 50 mM Tris-HCl, pH 7.5, 0.1 mM EGTA, 0.1 mM EDTA, 0.1% β-mercaptoethanol, 1 mg/mL bovine serum albumin, 10 mM MgOAc, 10 μM ATP, 0.2 μCi of [γ-33P]ATP, 7.5 μM substrate peptide (H2N-ARRRGVTTKTFCGT), and 60 ng of purified recombinant human PDK1. After 4 h at room temperature, we add 25 mM EDTA and spotted a portion of the reaction mixture on Whatman P81 phosphocellulose paper. The filter paper is washed three times with 0.75% phosphoric acid and once with acetone. After drying, the filter-bound labeled peptide is quantified using a Fuji phosphorimager.
Cell Research:[1]
+ Expand
  • Cell lines: MDA-468, PC-3, HCT-116 and MiaPaca cells
  • Concentrations: ~10 μM
  • Incubation Time: 72 hours
  • Method: Cells seeded at a low density (1,500–3,000 cells/well, 0.1 mL/well, 96-well plates) are incubated overnight. Compound treatments are made by adding 10 μL/well of the compound in 1% dimethyl sulfoxide and growth medium (final concentration of dimethyl sulfoxide, 0.1%), followed by brief shaking. Treated cells are incubated for 72 hours, and viability is measured by the addition of 10 μL of the metabolic dye WST-1. The WST-1 signal is read in a plate reader at 450 nm, and a no cell, or zero time cell, background is subtracted to calculate the net signal. Results are reported as the average ± S.E. of two or more replicates.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 100 mg/mL (169.07 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents individually and in order:
30% PEG400+0.5% Tween80+5% propylene glycol
30 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 591.47
Formula

C23H26IN7O2S

CAS No. 702675-74-9
Storage powder
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

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PDK Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID