BX-795

Catalog No.S1274

BX-795 Chemical Structure

Molecular Weight(MW): 591.47

BX795 is a potent and specific PDK1 inhibitor with IC50 of 6 nM, 140- and 1600-fold more selective for PDK1 than PKA and PKC in cell-free assays, respectively. Meanwhile, in comparison to GSK3β more than 100-fold selectivity observed for PDK1.

Size Price Stock Quantity  
In DMSO USD 200 In stock
USD 150 In stock
USD 320 In stock
USD 570 In stock
USD 970 In stock
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3 Customer Reviews

  • Induction of basal p62 Ser403 phosphorylation in ULK1/2-deficient MEF was suppressed by BX-795, an inhibitor of TBK1. WT ( Ulk1 +/+/Ulk2 +/+) and Ulk1 -/- /Ulk2 -/-(KO) MEF were treated with NaCl/Pi (Con) or 10 uM BX-795 for 6 h, and subjected to immunoblotting with indicated antibodies.

    FEBS J 2014 281(17), 3816-27. BX-795 purchased from Selleck.

    Virology 2014 450-451, 182-95. BX-795 purchased from Selleck.

  • Western blot analysis of pPRAS40 (T246), pS6 (S240/S244), and pS6 (S235/S236) proteins in (A) HeyA8 cells and (B) SKOV3 cells treated with 3.33 μM or 10 μM inhibitors (BX795 or CCT128930) in three-dimensional cell culture for 24 hours. Ten percent fetal bovine serum was used in A and B.

    PLoS One, 2016, 11(5):e0155052. . BX-795 purchased from Selleck.

Purity & Quality Control

Choose Selective PDK Inhibitors

Biological Activity

Description BX795 is a potent and specific PDK1 inhibitor with IC50 of 6 nM, 140- and 1600-fold more selective for PDK1 than PKA and PKC in cell-free assays, respectively. Meanwhile, in comparison to GSK3β more than 100-fold selectivity observed for PDK1.
Targets
TBK1/IKKɛ [2]
(Cell-free assay)
PDK-1 [1]
(Cell-free assay)
c-Kit [1]
(Cell-free assay)
CDK2/CyclinE [1]
(Cell-free assay)
Chk1 [1]
(Cell-free assay)
6 nM 320 nM 430 nM 510 nM
In vitro

BX-795 effectively blocks PDK1 activity in PC-3 cells, as shown by their ability to block phosphorylation of S6K1, Akt, PKCδ, and GSK3β. BX-795 potently inhibits tumor cell growth on plastic with IC50 of 1.6, 1.4, and 1.9 μM for MDA-468, HCT-116 and MiaPaca cells, respectively. In soft agar, BX-795 displays higher growth inhibition with IC50 of 0.72, and 0.25 μM for MDA-468, and PC-3 cells, respectively. [1] In addition, BX-795, as an inhibitor of the TBK1/IKKɛ, blocks TBK1- and IKKε-mediated activation of IRF3 and production of IFN-β. [2] In platelet physiological responses, BX795 produces inhibitory effect on 2-MeSADP-induced or collagen-induced aggregation, ATP secretion and thromboxane generation. [3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
human MV-4-11 cell MYfHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NFLkV49KdmirYnn0bY9vKG:oIHj1cYFvKE2YLUStNVEh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0{Pi56IH7N NIiye3lUSU6JRWK=
KRX cells M1f1[2Z2dmO2aX;uJIF{e2G7 MknIO{BucW6| MlnSTY5pcWKrdHnvckBw\iCVVV3PMZRi\2enZDDVUGsyKCi3bnvuc5dvKG:{aXfpckkhc2mwYYPlJIRwdWGrbjDlfJBz\XO|ZXSgbY4hU1K[IHPlcIx{KHW|aX7nJHs{OlCfLXfhcY1iNUGWUDDhcoQhdXmnbHnuJIJie2mlIIDyc5RmcW5ic4Xid5Rz[XSnIHnuZ5Vj[XSnZDDmc5IhPyCvaX7z Mn\QNlYzPzV4OEG=
human NKM-1 cell MXvHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MVXJcohq[mm2aX;uJI9nKGi3bXHuJG5MVS1zIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MD6zOlE6PCEQvF2= MkPTV2FPT0WU
human P30-OHK cell NXfkcXl{T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MlHzTY5pcWKrdHnvckBw\iCqdX3hckBROzBvT1jLJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHluIFnDOVA:OC52OU[1JO69VQ>? MXPTRW5ITVJ?
human YH-13 cell Mn3DS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NX7oNm5TUW6qaXLpeIlwdiCxZjDoeY1idiC\SD2xN{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVAvPjJ6OEig{txO NYHOOVVoW0GQR1XS
human LXF-289 cell MYfHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MV;Jcohq[mm2aX;uJI9nKGi3bXHuJGxZTi1{OEmgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfU4hUUN3ME2wMlY2Pjl|IN88US=> M336ZXNCVkeHUh?=
human BE-13 cell MYnHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NILtd29KdmirYnn0bY9vKG:oIHj1cYFvKEKHLUGzJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NE44ODR5NzFOwG0> M33rbHNCVkeHUh?=
human RS4-11 cell NYL3WFlwT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MoHQTY5pcWKrdHnvckBw\iCqdX3hckBTWzRvMUGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2wMlczPTl2IN88US=> M36xXXNCVkeHUh?=
human A3-KAW cell MULHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NVnwV3o{UW6qaXLpeIlwdiCxZjDoeY1idiCDMz3LRXch[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0xNjd|MEW1JO69VQ>? MYjTRW5ITVJ?
human PA-1 cell M4jLfGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M3i0XWlvcGmkaYTpc44hd2ZiaIXtZY4hWEFvMTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUCuPFA1OjJizszN M1;2WHNCVkeHUh?=
human ES7 cell NFq3dm9Iem:5dHigbY5pcWKrdHnvckBie3OjeR?= MYrJcohq[mm2aX;uJI9nKGi3bXHuJGVUPyClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTBwOEO1OlYh|ryP NV\JWWtKW0GQR1XS
human ES8 cell NFXMN3ZIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M3LKWWlvcGmkaYTpc44hd2ZiaIXtZY4hTVN6IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MD64OFM{PiEQvF2= NVLrRZQxW0GQR1XS
human SW982 cell MlvWS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NWLlbVdvUW6qaXLpeIlwdiCxZjDoeY1idiCVV{m4NkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVAvQTVzMkSg{txO NX3FTnViW0GQR1XS
human VA-ES-BJ cell NULx[2VOT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NEjGVHFKdmirYnn0bY9vKG:oIHj1cYFvKF[DLVXTMWJLKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OC57OES2O{DPxE1? Mmi2V2FPT0WU
human 697 cell NXnxT4tqT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NGjBUItKdmirYnn0bY9vKG:oIHj1cYFvKDZ7NzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGuNFE3OjNizszN NELZfHJUSU6JRWK=
human MOLT-4 cell NH3PSYRIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M4DJd2lvcGmkaYTpc44hd2ZiaIXtZY4hVU:OVD20JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU4xOzJ2NDFOwG0> MVfTRW5ITVJ?
human D-283MED cell M13SS2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MoHDTY5pcWKrdHnvckBw\iCqdX3hckBFNTJ6M13FSEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEvODN7NEig{rxu NFLUWY5USU6JRWK=
human ALL-PO cell MVzHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NV[1UIhmUW6qaXLpeIlwdiCxZjDoeY1idiCDTFytVG8h[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yNjB4MEezJO69VQ>? NEXZUGlUSU6JRWK=
human NB14 cell NUexTmpwT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M{e4bGlvcGmkaYTpc44hd2ZiaIXtZY4hVkJzNDDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGuNFYxQDFizszN MYXTRW5ITVJ?
human NTERA-S-cl-D1 cell M2O3Vmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M2m0UmlvcGmkaYTpc44hd2ZiaIXtZY4hVlSHUlGtV{1kdC2GMTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGuNFc4PzVizszN M1PyOnNCVkeHUh?=
human BFTC-905 cell Mnu5S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MVfJcohq[mm2aX;uJI9nKGi3bXHuJGJHXENvOUC1JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU4xQDFyMTFOwG0> NH22e5lUSU6JRWK=
human H4 cell NWLSTJZ6T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M4n0[2lvcGmkaYTpc44hd2ZiaIXtZY4hUDRiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1zLkGwNlAyKM7:TR?= M3:zSXNCVkeHUh?=
human CHP-212 cell NYHoOlFZT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M{n2dGlvcGmkaYTpc44hd2ZiaIXtZY4hS0iSLUKxNkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEvOTRyM{eg{txO NGX6eXhUSU6JRWK=
human A204 cell M4\NVmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MUfJcohq[mm2aX;uJI9nKGi3bXHuJGEzODRiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1zLkG1OFY4KM7:TR?= MUfTRW5ITVJ?
human NB69 cell NEnhZ|JIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M{DqO2lvcGmkaYTpc44hd2ZiaIXtZY4hVkJ4OTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGuNVU5PjVizszN NGXGNpNUSU6JRWK=
human P12-ICHIKAWA cell MmXlS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MmfRTY5pcWKrdHnvckBw\iCqdX3hckBROTJvSVPITWtCX0FiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1zLkG4NVcyKM7:TR?= M3zse3NCVkeHUh?=
human L-363 cell M3\sOmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M3f1T2lvcGmkaYTpc44hd2ZiaIXtZY4hVC1|NkOgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlE5OTl5IN88US=> MX3TRW5ITVJ?
human ES5 cell MY\Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? Mn;YTY5pcWKrdHnvckBw\iCqdX3hckBGWzViY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1zLkG5N|U1KM7:TR?= NXrKZmR3W0GQR1XS
human CAL-51 cell MW\Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NX33TXlvUW6qaXLpeIlwdiCxZjDoeY1idiCFQVytOVEh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yNjJ{MUW2JO69VQ>? M4\abHNCVkeHUh?=
human NBsusSR cell M1TOXWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M2TITGlvcGmkaYTpc44hd2ZiaIXtZY4hVkK|dYPTVkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEvOjR3N{ig{txO M1rWTXNCVkeHUh?=
human HOP-92 cell M1vjUmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MYHJcohq[mm2aX;uJI9nKGi3bXHuJGhQWC17MjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGuNlczQTNizszN MlPhV2FPT0WU
human DU-4475 cell M1zTVGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MoDFTY5pcWKrdHnvckBw\iCqdX3hckBFXS12NEe1JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU4zQTJ2NTFOwG0> MmnYV2FPT0WU
human LB1047-RCC cell M1HOWmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MoThTY5pcWKrdHnvckBw\iCqdX3hckBNSjFyNEetVmNEKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OS5{OUK4NUDPxE1? NXvuO3kyW0GQR1XS
human D-566MG cell NUnmR3FOT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MUjJcohq[mm2aX;uJI9nKGi3bXHuJGQuPTZ4TVegZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlMxPDR6IN88US=> NV\tN4ZsW0GQR1XS
human A375 cell MlvwS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NYXUNpk6UW6qaXLpeIlwdiCxZjDoeY1idiCDM{e1JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU4{ODh3ODFOwG0> NF3yNWxUSU6JRWK=
human ATN-1 cell NH;seXVIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M172XWlvcGmkaYTpc44hd2ZiaIXtZY4hSVSQLUGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlM4OTh3IN88US=> NGLmUJpUSU6JRWK=
human M059J cell MVzHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MYDJcohq[mm2aX;uJI9nKGi3bXHuJG0xPTmMIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MT6zO|Y2OiEQvF2= MYrTRW5ITVJ?
human HSC-3 cell MnvDS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MmO5TY5pcWKrdHnvckBw\iCqdX3hckBJW0NvMzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGuOFQzODhizszN NFu2Z4FUSU6JRWK=
human DOHH-2 cell NHThXldIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NXvYRpVIUW6qaXLpeIlwdiCxZjDoeY1idiCGT1jIMVIh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yNjR3OEG0JO69VQ>? M1jCRXNCVkeHUh?=
human G-402 cell MU\Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NUm5fIlzUW6qaXLpeIlwdiCxZjDoeY1idiCJLUSwNkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEvPDZ3MkWg{txO M4HCXHNCVkeHUh?=
human LC-2-ad cell M4PrZWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 Mm\rTY5pcWKrdHnvckBw\iCqdX3hckBNSy1{LXHkJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU41PzF|MjFOwG0> MXHTRW5ITVJ?
human LOXIMVI cell MmTuS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NGm0[mxKdmirYnn0bY9vKG:oIHj1cYFvKEyRWFnNWmkh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yNjVyNUWyJO69VQ>? MY\TRW5ITVJ?
human DK-MG cell NFHVT|NIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NELCR3pKdmirYnn0bY9vKG:oIHj1cYFvKESNLV3HJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU42PzJ7ODFOwG0> MYLTRW5ITVJ?
human HOS cell MVTHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MkHYTY5pcWKrdHnvckBw\iCqdX3hckBJV1NiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1zLkW3N|A6KM7:TR?= NXHGPZNFW0GQR1XS
human BHT-101 cell NUTaWZB3T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M2jHZWlvcGmkaYTpc44hd2ZiaIXtZY4hSkiWLUGwNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEvPTd6N{eg{txO NG[0RVlUSU6JRWK=
human U-2-OS cell MmWwS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MV;Jcohq[mm2aX;uJI9nKGi3bXHuJHUuOi2RUzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGuOVg5ODZizszN NWHmRmoxW0GQR1XS
human D-423MG cell NYH6dFNFT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MU\Jcohq[mm2aX;uJI9nKGi3bXHuJGQuPDJ|TVegZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlYxQDB4IN88US=> NWfLco5kW0GQR1XS
human AN3-CA cell NVvye3l4T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MWrJcohq[mm2aX;uJI9nKGi3bXHuJGFPOy2FQTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGuOlM6QTFizszN NVPrVHVxW0GQR1XS
human TE-11 cell NGjEfVhIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M3G2emlvcGmkaYTpc44hd2ZiaIXtZY4hXEVvMUGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlY2OjhizszN MoXpV2FPT0WU
human SK-NEP-1 cell Mm\GS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MV3Jcohq[mm2aX;uJI9nKGi3bXHuJHNMNU6HUD2xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU43PTN5NjFOwG0> NFu4W|FUSU6JRWK=
human MG-63 cell Mn75S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M3TEXmlvcGmkaYTpc44hd2ZiaIXtZY4hVUdvNkOgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlY5PTZ5IN88US=> MlP5V2FPT0WU
human RH-1 cell MnHLS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MUDJcohq[mm2aX;uJI9nKGi3bXHuJHJJNTFiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1zLkewNlc1KM7:TR?= M2q5enNCVkeHUh?=
human MDA-MB-157 cell MWrHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NGDiWJZKdmirYnn0bY9vKG:oIHj1cYFvKE2GQT3NRk0yPTdiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1zLkexOlc1KM7:TR?= MlrJV2FPT0WU
human A427 cell MnLwS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M1jFPWlvcGmkaYTpc44hd2ZiaIXtZY4hSTR{NzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGuO|M2QDlizszN M2nCOXNCVkeHUh?=
human ES1 cell NX3ne3NFT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NYXVO5VTUW6qaXLpeIlwdiCxZjDoeY1idiCHU{GgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlc2PDVzIN88US=> M4L6XHNCVkeHUh?=
human C32 cell NHHT[49Iem:5dHigbY5pcWKrdHnvckBie3OjeR?= M4H5T2lvcGmkaYTpc44hd2ZiaIXtZY4hSzN{IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MT63OlM6KM7:TR?= MWDTRW5ITVJ?
human LAMA-84 cell MoPCS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M3ixRWlvcGmkaYTpc44hd2ZiaIXtZY4hVEGPQT24OEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEvPzZ6N{Kg{txO NHzDZm5USU6JRWK=
human YKG-1 cell MnnhS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MWLJcohq[mm2aX;uJI9nKGi3bXHuJHlMTy1zIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MT63O|EzPCEQvF2= MUXTRW5ITVJ?
human NCI-H1048 cell MVzHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NVLJT4M3UW6qaXLpeIlwdiCxZjDoeY1idiCQQ1mtTFExPDhiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1zLke4OVA6KM7:TR?= MVPTRW5ITVJ?
human KS-1 cell NFrW[pBIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M4rDfGlvcGmkaYTpc44hd2ZiaIXtZY4hU1NvMTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGuPFI6QCEQvF2= NWPCOndnW0GQR1XS
human JVM-3 cell M3Sxemdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M3vW[WlvcGmkaYTpc44hd2ZiaIXtZY4hUl[PLUOgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlg3PDlzIN88US=> M2PYO3NCVkeHUh?=
human GI-ME-N cell NXTnU4JHT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MUHJcohq[mm2aX;uJI9nKGi3bXHuJGdKNU2HLV6gZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlg3PTNizszN MoX2V2FPT0WU
human GT3TKB cell M4n5XGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NF33dmtKdmirYnn0bY9vKG:oIHj1cYFvKEeWM2TLRkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEvQDl4NEKg{txO M4jEOnNCVkeHUh?=
human CHL-1 cell NUfSSYJbT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MnG4TY5pcWKrdHnvckBw\iCqdX3hckBEUExvMTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGuPVI{PzlizszN MWjTRW5ITVJ?
human CHP-134 cell NVLMb2NrT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NV;3Nm1uUW6qaXLpeIlwdiCxZjDoeY1idiCFSGCtNVM1KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OS57NES2O{DPxE1? MlPHV2FPT0WU
human 8-MG-BA cell MWLHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M1O1dmlvcGmkaYTpc44hd2ZiaIXtZY4hQC2PRz3CRUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEvQTV5NESg{txO Mn;HV2FPT0WU
human HO-1-N-1 cell MYHHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MYXJcohq[mm2aX;uJI9nKGi3bXHuJGhQNTFvTj2xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU46PzFzNzFOwG0> NEK4RWJUSU6JRWK=
human SW1088 cell NFyzSGlIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NH;ZTpdKdmirYnn0bY9vKG:oIHj1cYFvKFOZMUC4PEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEvQTl4N{Og{txO MYHTRW5ITVJ?
human SW48 cell NWfhT5lxT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MmG5TY5pcWKrdHnvckBw\iCqdX3hckBUXzR6IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Mj6wNlA3PyEQvF2= MkT1V2FPT0WU
human VM-CUB-1 cell MYDHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MYXJcohq[mm2aX;uJI9nKGi3bXHuJHZONUOXQj2xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Nk4xPDFzOTFOwG0> NH3ZTYRUSU6JRWK=
human COLO-800 cell MWXHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MkXzTY5pcWKrdHnvckBw\iCqdX3hckBEV0yRLUiwNEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIvODVzM{[g{txO M1HFPXNCVkeHUh?=
human TI-73 cell NEP6R3FIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M1zZS2lvcGmkaYTpc44hd2ZiaIXtZY4hXElvN{OgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yMlEyOzl7IN88US=> NELpO2JUSU6JRWK=
human HN cell MmDQS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NVS4eFFiUW6qaXLpeIlwdiCxZjDoeY1idiCKTjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUKuNVIyQThizszN NG\OcJBUSU6JRWK=
human DB cell M3PhU2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MnroTY5pcWKrdHnvckBw\iCqdX3hckBFSiClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTJwMUK2N|Eh|ryP NFz2dWhUSU6JRWK=
human Ca9-22 cell NXnxWnJQT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NGKzW2JKdmirYnn0bY9vKG:oIHj1cYFvKEOjOT2yNkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIvOTJ6NEeg{txO Ml;xV2FPT0WU
human A549 cell MXfHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MY\Jcohq[mm2aX;uJI9nKGi3bXHuJGE2PDliY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1{LkGzPFA5KM7:TR?= NH7ic2RUSU6JRWK=
human KGN cell NEnQVWJIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NG\MN2ZKdmirYnn0bY9vKG:oIHj1cYFvKEuJTjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUKuNlI2QTVizszN Mn7tV2FPT0WU
human BCPAP cell MWHHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NFnOTFdKdmirYnn0bY9vKG:oIHj1cYFvKEKFUFHQJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Nk4zOzF3ODFOwG0> MkPJV2FPT0WU
human Ramos-2G6-4C10 cell MlLwS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M3Tm[GlvcGmkaYTpc44hd2ZiaIXtZY4hWmGvb4OtNmc3NTSFMUCgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yMlI{PzV7IN88US=> NXvQVIVkW0GQR1XS
human OVCAR-5 cell Mo[2S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MXzJcohq[mm2aX;uJI9nKGi3bXHuJG9XS0GULUWgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yMlI4PzN2IN88US=> MojTV2FPT0WU
human KG-1 cell MUHHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NYr2SVFZUW6qaXLpeIlwdiCxZjDoeY1idiCNRz2xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Nk4zPzd7MjFOwG0> NGXrOVdUSU6JRWK=
human CAKI-1 cell MWnHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NYrDWmFOUW6qaXLpeIlwdiCxZjDoeY1idiCFQVvJMVEh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0zNjJ6MEW4JO69VQ>? NWPNSohwW0GQR1XS
human QIMR-WIL cell Ml71S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MYrJcohq[mm2aX;uJI9nKGi3bXHuJHFKVVJvV1nMJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Nk4zQDd2NDFOwG0> MXLTRW5ITVJ?
human SW1710 cell NF35NoZIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MomxTY5pcWKrdHnvckBw\iCqdX3hckBUXzF5MUCgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yMlI6OTR{IN88US=> NHXRdJVUSU6JRWK=
human SK-UT-1 cell NVvYXnFoT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NVHwNWxsUW6qaXLpeIlwdiCxZjDoeY1idiCVSz3VWE0yKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:Oi5{OUOzPUDPxE1? Moe1V2FPT0WU
human IST-SL1 cell MYjHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M3z2fGlvcGmkaYTpc44hd2ZiaIXtZY4hUVOWLWPMNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIvOzJzN{Sg{txO NXXhV4NNW0GQR1XS
human SW962 cell MVHHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NVP2VGV4UW6qaXLpeIlwdiCxZjDoeY1idiCVV{m2NkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIvOzN5NUeg{txO NELNT|FUSU6JRWK=
human EM-2 cell M1TRO2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 Mn\pTY5pcWKrdHnvckBw\iCqdX3hckBGVS1{IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Mj6zOVM{PyEQvF2= NH3BUGhUSU6JRWK=
human D-263MG cell MUXHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MUjJcohq[mm2aX;uJI9nKGi3bXHuJGQuOjZ|TVegZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yMlM5OzJ5IN88US=> MmnmV2FPT0WU
human T98G cell MWjHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NGPP[YpKdmirYnn0bY9vKG:oIHj1cYFvKFR7OFegZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yMlM5QDV5IN88US=> NWTwc3pWW0GQR1XS
human CTB-1 cell MlrVS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NYPhNm0zUW6qaXLpeIlwdiCxZjDoeY1idiCFVFKtNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIvOzl5NkGg{txO NIi1e4dUSU6JRWK=
human Hs-578-T cell NXXkTZRST3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NFizVmhKdmirYnn0bY9vKG:oIHj1cYFvKEi|LUW3PE1VKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:Oi52MUW4O{DPxE1? MUfTRW5ITVJ?
human SF126 cell NUe4e|h5T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NX7acXBtUW6qaXLpeIlwdiCxZjDoeY1idiCVRkGyOkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIvPDN4MkGg{txO MV7TRW5ITVJ?
human NCI-H460 cell Mn3hS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NWXDeWhsUW6qaXLpeIlwdiCxZjDoeY1idiCQQ1mtTFQ3OCClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTJwNEO5OVUh|ryP MoTmV2FPT0WU
human NCI-H1755 cell NVu4PHdOT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MnPMTY5pcWKrdHnvckBw\iCqdX3hckBPS0lvSEG3OVUh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0zNjV2MESzJO69VQ>? MULTRW5ITVJ?
human HL-60 cell Mn3jS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M2HZUmlvcGmkaYTpc44hd2ZiaIXtZY4hUExvNkCgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yMlU1OTV7IN88US=> MVjTRW5ITVJ?
human G-401 cell M{PXe2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NFXPb|dKdmirYnn0bY9vKG:oIHj1cYFvKEdvNECxJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Nk42PjB7OTFOwG0> NFnZ[nFUSU6JRWK=
human AGS cell MmPJS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NULkW|VuUW6qaXLpeIlwdiCxZjDoeY1idiCDR2OgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yMlU3OjV5IN88US=> NVfHRVNPW0GQR1XS
human HuO9 cell MWjHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MXLJcohq[mm2aX;uJI9nKGi3bXHuJGh2VzliY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1{LkW2OFU3KM7:TR?= NWDvV3lxW0GQR1XS
human MFE-280 cell NYfzS3ZPT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NHLrVGxKdmirYnn0bY9vKG:oIHj1cYFvKE2IRT2yPFAh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0zNjV4Nki2JO69VQ>? NEXmV|RUSU6JRWK=
human NCI-H292 cell NXvpS|F3T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M37TSmlvcGmkaYTpc44hd2ZiaIXtZY4hVkOLLViyPVIh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0zNjV5N{KyJO69VQ>? MWjTRW5ITVJ?
human HuO-3N1 cell NYfMUpk4T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NXTLT3pKUW6qaXLpeIlwdiCxZjDoeY1idiCKdV:tN24yKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:Oi54MEOwO{DPxE1? Mke2V2FPT0WU
human ES3 cell MlPHS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NHPTR3RKdmirYnn0bY9vKG:oIHj1cYFvKEWVMzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUKuOlIzQDVizszN MojFV2FPT0WU
human LB2241-RCC cell NIPZU5JIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NIHOZYxKdmirYnn0bY9vKG:oIHj1cYFvKEyEMkK0NU1TS0NiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1{Lk[5NFc6KM7:TR?= NF7QfolUSU6JRWK=
human NCI-H1155 cell MmnKS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NH7zdmNKdmirYnn0bY9vKG:oIHj1cYFvKE6FST3INVE2PSClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTJwNkm0NFUh|ryP NVv3[YpuW0GQR1XS
human SW872 cell MoD4S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NUTveG9jUW6qaXLpeIlwdiCxZjDoeY1idiCVV{i3NkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIvPzB4N{[g{txO NXjDOYlpW0GQR1XS
human MHH-ES-1 cell NFjVcHZIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MlP6TY5pcWKrdHnvckBw\iCqdX3hckBOUEhvRWOtNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIvPzJ4M{Og{txO MVHTRW5ITVJ?
human KYSE-150 cell NIPGfJFIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MlHLTY5pcWKrdHnvckBw\iCqdX3hckBMYVOHLUG1NEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIvPzJ7NzFOwG0> MmTIV2FPT0WU
human MC-IXC cell MVjHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MnfuTY5pcWKrdHnvckBw\iCqdX3hckBOSy2LWFOgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yMlg6PTNizszN MmnCV2FPT0WU
human HCC1187 cell MXjHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MYjJcohq[mm2aX;uJI9nKGi3bXHuJGhESzFzOEegZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yMlg6Pjd5IN88US=> MUjTRW5ITVJ?
human UMC-11 cell NXPzd5Z3T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M2fDW2lvcGmkaYTpc44hd2ZiaIXtZY4hXU2FLUGxJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Nk46ODR5NzFOwG0> M3P1R3NCVkeHUh?=
human NB5 cell MYjHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MnPaTY5pcWKrdHnvckBw\iCqdX3hckBPSjViY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1{LkmzO|E2KM7:TR?= NGj0VmxUSU6JRWK=
human A2058 cell MlTzS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M1rXZWlvcGmkaYTpc44hd2ZiaIXtZY4hSTJyNUigZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yMlk4QDR2IN88US=> M2HMWHNCVkeHUh?=
human Becker cell M3rBOWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MYXJcohq[mm2aX;uJI9nKGi3bXHuJGJm[2uncjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUOuNFEyOTJizszN NH3mbmhUSU6JRWK=
human CAS-1 cell NUD1UGFJT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M1XSNGlvcGmkaYTpc44hd2ZiaIXtZY4hS0GVLUGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2zMlAyPTZ7IN88US=> NILQN5JUSU6JRWK=
human SW780 cell NVXiOFZLT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MlLLTY5pcWKrdHnvckBw\iCqdX3hckBUXzd6MDDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUOuNlU3ODlizszN NGjIRo9USU6JRWK=
human KM12 cell M1TpN2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M16xT2lvcGmkaYTpc44hd2ZiaIXtZY4hU01zMjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUOuN|AyOzJizszN M4KxUnNCVkeHUh?=
human PC-3 cell M{HsUWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MYDJcohq[mm2aX;uJI9nKGi3bXHuJHBENTNiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD12LkG3OFEyKM7:TR?= M3K3R3NCVkeHUh?=
human A253 cell NWrpe3FRT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NYXN[ZhvUW6qaXLpeIlwdiCxZjDoeY1idiCDMkWzJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9OE4yQDh7MzFOwG0> MorBV2FPT0WU
human NB10 cell MlrtS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MljGTY5pcWKrdHnvckBw\iCqdX3hckBPSjFyIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;ND6yNlc4OyEQvF2= NHrLb5dUSU6JRWK=
human A172 cell MVHHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M2rDRWlvcGmkaYTpc44hd2ZiaIXtZY4hSTF5MjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUSuOFQ2PyEQvF2= NVrieGljW0GQR1XS
human A498 cell M3n3bGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NUfGbYxHUW6qaXLpeIlwdiCxZjDoeY1idiCDNEm4JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9OE42PjN6MzFOwG0> NWi0TmJOW0GQR1XS
human SW1573 cell MXXHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NI\xe|dKdmirYnn0bY9vKG:oIHj1cYFvKFOZMUW3N{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVYvQTB2OUGg{txO Mle5V2FPT0WU
human 5637 cell NHLLd5FIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NVzBXlg1UW6qaXLpeIlwdiCxZjDoeY1idiB3NkO3JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9PE4xPzlyNDFOwG0> NELxSnNUSU6JRWK=
human A388 cell NWD5T2NnT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MYTJcohq[mm2aX;uJI9nKGi3bXHuJGE{QDhiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1{MT6xN|k5KM7:TR?= NYHvRndUW0GQR1XS
human U251 cell NV7Bc4dKT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= Mn\LTY5pcWKrdHnvckBw\iCqdX3hckBWOjVzIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MkiuNVE4PSEQvF2= NHHwTmFUSU6JRWK=

... Click to View More Cell Line Experimental Data

Protocol

Kinase Assay:[1]
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Kinase assays:

PDK1 is assayed in a direct kinase assay and a coupled assay format measuring PDK1- and PtdIns-3,4-P2-mediated activation of AKT2. For the coupled assay, the final assay mixture (60 μL) contained: 15 mM MOPS, pH 7.2, 1 mg/mL bovine serum albumin, 18 mM β-glycerol phosphate, 0.7 mM dithiothreitol, 3 mM EGTA, 10 mM MgOAc, 7.5 μM ATP, 0.2 μCi of [γ-33P]ATP, 7.5 μM biotinylated peptide substrate (biotin-ARRRDGGGAQPFRPRAATF), 0.5 μL of PtdIns-3,4-P2-containing phospholipid vesicles, 60 pg of purified recombinant human PDK1, and 172 ng of purified recombinant human AKT2. After incubation for 2 h at room temperature, the biotin-labeled peptide is captured from 10 μl of the assay mixture on streptavidin-coated SPA beads, and product formation is measured by scintillation proximity in a Wallac MicroBeta counter. The product formed is proportional to the time of incubation and to the amount of PDK1 and inactive AKT2 added. PDK1 is added at suboptimal levels so that the assay could sensitively detect inhibitors of AKT2 activation as well as direct inhibitors of PDK1 or AKT2. To measure PDK1 activity directly, the final assay mixture (60 μL) contained 50 mM Tris-HCl, pH 7.5, 0.1 mM EGTA, 0.1 mM EDTA, 0.1% β-mercaptoethanol, 1 mg/mL bovine serum albumin, 10 mM MgOAc, 10 μM ATP, 0.2 μCi of [γ-33P]ATP, 7.5 μM substrate peptide (H2N-ARRRGVTTKTFCGT), and 60 ng of purified recombinant human PDK1. After 4 h at room temperature, we add 25 mM EDTA and spotted a portion of the reaction mixture on Whatman P81 phosphocellulose paper. The filter paper is washed three times with 0.75% phosphoric acid and once with acetone. After drying, the filter-bound labeled peptide is quantified using a Fuji phosphorimager.
Cell Research:[1]
+ Expand
  • Cell lines: MDA-468, PC-3, HCT-116 and MiaPaca cells
  • Concentrations: ~10 μM
  • Incubation Time: 72 hours
  • Method: Cells seeded at a low density (1,500–3,000 cells/well, 0.1 mL/well, 96-well plates) are incubated overnight. Compound treatments are made by adding 10 μL/well of the compound in 1% dimethyl sulfoxide and growth medium (final concentration of dimethyl sulfoxide, 0.1%), followed by brief shaking. Treated cells are incubated for 72 hours, and viability is measured by the addition of 10 μL of the metabolic dye WST-1. The WST-1 signal is read in a plate reader at 450 nm, and a no cell, or zero time cell, background is subtracted to calculate the net signal. Results are reported as the average ± S.E. of two or more replicates.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 100 mg/mL (169.07 mM)
Water <1 mg/mL
Ethanol <1 mg/mL
In vivo 30% PEG400+0.5% Tween80+5% propylene glycol 30 mg/mL

* 1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 591.47
Formula

C23H26IN7O2S

CAS No. 702675-74-9
Storage powder
in solvent
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

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PDK Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID