IKK-16 (IKK Inhibitor VII)

Catalog No.S2882

IKK-16 (IKK Inhibitor VII) Chemical Structure

Molecular Weight(MW): 483.63

IKK-16 (IKK Inhibitor VII) is a selective IκB kinase (IKK) inhibitor for IKK-2, IKK complex and IKK-1 with IC50 of 40 nM, 70 nM and 200 nM in cell-free assays, respectively.

Size Price Stock Quantity  
In DMSO USD 220 In stock
USD 170 In stock
USD 670 In stock

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2 Customer Reviews

  • Reduction in IFN-g production in TcREG by IKK-16 coincides with decrease in T-bet and Eomes expression levels. Flow cytometry plots showing cellular analysis for T-bet and Eomes in CD45+CD3+CD8+ population.

    J Immunol, 2016, 197(3):726-35.. IKK-16 (IKK Inhibitor VII) purchased from Selleck.

    mBM-DCs were preincubated with the indicated inhibitors for 30 min and then treated with or without 20 mM dryocrassin. After 1 h of incubation, the cells were washed, followed by stimulation with 100 ng/ml LPS for 20 h. The detection of phosphorylated forms of IKK, JNK, and p38 MAPK by Western blot analysis with specific antibodies.

    Cell Transplant, 2014, 23(4-5): 641-56. IKK-16 (IKK Inhibitor VII) purchased from Selleck.

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Notes:

2. For more details, such as half maximal inhibitory concentrations (IC50s) and working concentrations of each inhibitor, please click on the link of the inhibitor of interest.
3. "+" indicates inhibitory effect. Increased inhibition is marked by a higher "+" designation.
4. Orange "√" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

Biological Activity

Description IKK-16 (IKK Inhibitor VII) is a selective IκB kinase (IKK) inhibitor for IKK-2, IKK complex and IKK-1 with IC50 of 40 nM, 70 nM and 200 nM in cell-free assays, respectively.
Targets
IKK2 [1]
(Cell-free assay)
IKK complex [1]
(Cell-free assay)
IKK1 [1]
(Cell-free assay)
40 nM 70 nM 200 nM
In vitro

IKK-16 inhibits TNFα-stimulated expression of the adhesion molecules E-selectin, ICAM-1, and VCAM-1 in HUVEC cells. Although IKK-16 shows activity in the IFNγ-induced expression of β2 microglobulin or HLA-DR, its potency in these assays is 4- to 10-fold weaker. [1]

In vivo IKK-16 is orally bio-available in rats and mice, and it inhibits LPS-induced TNF-α release in vivo and neutrophil extravasion in thioglycollate-induced peritonitis.[1]

Protocol

Solubility (25°C)

In vitro DMSO 97 mg/mL (200.56 mM)
Water <1 mg/mL
Ethanol <1 mg/mL
In vivo 30% PEG400+0.5% Tween80+5% propylene glycol 30 mg/mL

* 1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 483.63
Formula

C28H29N5OS

CAS No. 873225-46-8
Storage powder
in solvent
Synonyms N/A

Bio Calculators

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID