CAS No. 2489404-97-7
Batch:
Purity:99.84
Chemical Structure
Check the
Osunprotafib (ABBV-CLS-484)
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 5-[(7R)-1-fluoro-3-hydroxy-7-(3-methylbutylamino)-5,6,7,8-tetrahydronaphthalen-2-yl]-1,1-dioxo-1,2,5-thiadiazolidin-3-one | |
|---|---|---|
| CAS Number | 2489404-97-7 | |
| Molecular Formula |
C17H24FN3O4S |
|
| Molecular Weight (MW) | 385.46 | |
| InChIKey | DVFCRTGTEXUFIN-GFCCVEGCSA-N |
Osunprotafib (ABBV-CLS-484) is an orally bioavailable, active-site inhibitor of protein tyrosine phosphatases PTPN2 and PTPN1 with sub-nanomolar activity. Inhibition of PTPN2 and PTPN1 amplifies cellular responses to interferon and enhances downstream JAK-STAT signaling. This activation promotes natural killer cell and CD8+ T cell function, reduces T cell dysfunction, and generates potent anti-tumor immunity within resistant tumor microenvironments. [1]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
77 mg/mL
(199.76 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
- Osunprotafib (ABBV-CLS-484) Mechanism of Action: PTPN2 Inhibition in T Cell Research
- Osunprotafib (ABBV-CLS-484) Clinical Trials
- Osunprotafib (ABBV-CLS-484): Selectivity & Specificity
- Osunprotafib (ABBV-CLS-484) Working Concentration | Cell Culture | Treatment
- Osunprotafib (ABBV-CLS-484) Solubility in DMSO
- Osunprotafib (ABBV-CLS-484) Stock Solution
- Osunprotafib (ABBV-CLS-484) Storage
- Osunprotafib (ABBV-CLS-484) Stability
- Osunprotafib (ABBV-CLS-484) Combination Database
- Osunprotafib (ABBV-CLS-484) Molecular Weight
- Osunprotafib (ABBV-CLS-484) Chemical Structure (2D and 3D)
- Osunprotafib (ABBV-CLS-484) IC50 for Cell-based and Cell-free Assays
- Osunprotafib (ABBV-CLS-484) Sigma (TA9H998A2E17)? Try a better option.
- Osunprotafib (ABBV-CLS-484) MedChemExpress (HY-145923)? Try a better option.
- Osunprotafib (ABBV-CLS-484) Cayman (40169)? Try a better option.
- Osunprotafib (ABBV-CLS-484) Axonmedchem (Axon 3729)? Try a better option.
- Osunprotafib (ABBV-CLS-484) AbMole (M11444)? Try a better option.
- Osunprotafib (ABBV-CLS-484) SDS｜MSDS
Note: Technical data last updated: Sep 1, 2026.