Osunprotafib (ABBV-CLS-484): Selectivity & Specificity
Osunprotafib (ABBV-CLS-484) is a potent inhibitor of PTP1B (1.84 ± 0.09 nM), PTPN2 (1.60 ± 0.06 nM), PTPN1 (2.5 nM). Osunprotafib (ABBV-CLS-484) exhibits the greatest inhibitory potency toward PTPN2 (IC50 = 1.60 ± 0.06 nM).