Target Selectivity of Osunprotafib (ABBV-CLS-484)
| Key Target | IC50 | Description | Reference |
|---|---|---|---|
| PTPN2 | 1.6 nM | PTP kinetic assay using 6,8-Di fluoro-4-Methylumbelliferyl Phosphate (DiFMUP) as a substrate | PM37500611 |
| PTP1B | 1.84 nM | PTP kinetic assay using 6,8-Di fluoro-4-Methylumbelliferyl Phosphate (DiFMUP) as a substrate | PM37500611 |
| PTPN1 | 2.5 nM | Mobility shift assay, Fluorescence assay (DiFMUP substrate) | PM37794185 |
Check the
Osunprotafib (ABBV-CLS-484)
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Cell-free Assays (IC50/Ki) for Osunprotafib (ABBV-CLS-484)
| Key Target | IC50 (Cell-free) | Description | Reference |
|---|---|---|---|
| No published data available. | |||
Cell-based Assay (IC50) for Osunprotafib (ABBV-CLS-484)
| Cell Type | IC50 (Cell-based) | Description | Reference |
|---|---|---|---|
| B16 cells | 176 nM | Phospho-STAT1 (Tyr701) Cellular HTRF kit | PM37794185 |
| B16 cells | 0.064 μM (with IFNγ) | IncuCyte S3 Live-Cell Analysis system (confluence) | PM37794185 |
Jump to
- Osunprotafib (ABBV-CLS-484) Mechanism of Action: PTPN2 Inhibition in T Cell Research
- Osunprotafib (ABBV-CLS-484) Clinical Trials
- Osunprotafib (ABBV-CLS-484) Working Concentration | Cell Culture | Treatment
- Osunprotafib (ABBV-CLS-484) Solubility in DMSO
- Osunprotafib (ABBV-CLS-484) Stock Solution
- Osunprotafib (ABBV-CLS-484) Storage
- Osunprotafib (ABBV-CLS-484) Stability
- Osunprotafib (ABBV-CLS-484) Combination Database
- Osunprotafib (ABBV-CLS-484) Molecular Weight
- Osunprotafib (ABBV-CLS-484) CAS Number
- Osunprotafib (ABBV-CLS-484) Chemical Structure (2D and 3D)
- Osunprotafib (ABBV-CLS-484) IC50 for Cell-based and Cell-free Assays
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- Osunprotafib (ABBV-CLS-484) SDS｜MSDS