Osunprotafib (ABBV-CLS-484) Solubility in DMSO

In Vitro Solubility

Batch:

All in vitro solubility values are batch-tested experimental data (non-literature values).

Solvent	Solubility & Note
DMSO	77 mg/mL (199.76 mM) (Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water	Insoluble
Ethanol	Insoluble

FAQ

Q: Why does a DMSO stock precipitate in media/saline?

A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.

How to fix it?

Check the Osunprotafib (ABBV-CLS-484) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Concentration Volume Mass

Batch:

Administration Route	Formulation Type	Formulation Details	Solubility	Preparation Method
Oral Administration	Homogeneous suspensionCMC-NA	CMC-NA	≥5mg/mL	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Injection	Clear solution	5%DMSO 1 40%PEG300 2 5%Tween80 3 50%ddH2O Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.	3.850mg/mL (9.99mM)	Taking the 1 mL working solution as an example, add 50 μL of 77 mg/ml clarified DMSO stock solution to 400 μL of PEG300, mix evenly to clarify it; add 50 μL of Tween80 to the above system, mix evenly to clarify; then continue to add 500 μL of ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results.
Injection	Clear solution	5% DMSO 1 95% Corn oil Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.	0.960mg/mL (2.49mM)	Taking the 1 mL working solution as an example, add 50 μL of 19.2 mg/ml clear DMSO stock solution to 950 μL of corn oil and mix evenly. The mixed solution should be used immediately for optimal results.

Other Animals:

Dosage: mg/kg

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Avg Wt: g

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Vol/Animal: μL

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Animals:

% DMSO

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% PEG300

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% Tween 80

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% ddH₂O