CAS No. 6385-02-0

Batch: Purity:99.93
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Meclofenamate Sodium Chemical Structure
Chemical Structure
Check the Meclofenamate Sodium product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name sodium 2-(2,6-dichloro-3-methylanilino)benzoate
CAS Number 6385-02-0
Molecular Formula

C14H11Cl2NO2.Na
Molecular Weight (MW) 318.13
SMILES CC1=C(C(=C(C=C1)Cl)NC2=CC=CC=C2C(=O)[O-])Cl.[Na+]
InChIKey OGPIIGMUPMPMNT-UHFFFAOYSA-M

Ordering Information

Biological Activity

Meclofenamate Sodium is a dual cyclooxygenase (COX-1/COX-2) inhibitor and a selective inhibitor of fat mass and obesity-associated protein (FTO) demethylase. It competes with single-stranded RNA for FTO binding, selectively inhibiting N6-methyladenosine (m6A) demethylation without affecting ALKBH5 activity. This targeted inhibition modulates m6A RNA modification pathways, impairing downstream oncogenic gene expression and cell proliferation. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 63 mg/mL (198.03 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water 63 mg/mL
Ethanol 63 mg/mL
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.