Home Metabolism PPAR agonist GW1929 For research use only.

GW1929

GW1929 is a potent and selective agonist of PPARγ with a pKi of 8.84 for human PPARγ and pEC50 of 8.56 and 8.27 in human and murine receptors, respectively. It exhibits potential clinical benefits in managing diabetic dyslipidemias and cardiovascular risk factors through its lipid-lowering effects and improved insulin sensitivity mediated by PPARγ activation.

GW1929 Chemical Structure

GW1929 Chemical Structure

CAS No. 196808-24-9

Purity & Quality Control

Batch: S802701 Ethanol]8 mg/mL]false]DMSO]Insoluble]false]Water]Insoluble]false Purity: 99.13%
99.13

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Biological Activity

Description GW1929 is a potent and selective agonist of PPARγ with a pKi of 8.84 for human PPARγ and pEC50 of 8.56 and 8.27 in human and murine receptors, respectively. It exhibits potential clinical benefits in managing diabetic dyslipidemias and cardiovascular risk factors through its lipid-lowering effects and improved insulin sensitivity mediated by PPARγ activation.
  • https://pubmed.ncbi.nlm.nih.gov/10389847/

Chemical Information & Solubility

Molecular Weight 495.57 Formula

C30H29N3O4
CAS No. 196808-24-9 SDF Download GW1929 SDF
Storage (From the date of receipt) 2 years -80 in solvent

In vitro
Batch:

Ethanol : 8 mg/mL

DMSO : Insoluble ( Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

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Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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