CAS No. 116686-15-8
Batch:
Purity:98.69
Chemical Structure
Check the
FK-3311
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | N-[4-acetyl-2-(2,4-difluorophenoxy)phenyl]methanesulfonamide | |
|---|---|---|
| CAS Number | 116686-15-8 | |
| Molecular Formula |
C15H13F2NO4S |
|
| Molecular Weight (MW) | 341.33 | |
| SMILES | CC(=O)C1=CC(=C(C=C1)NS(=O)(=O)C)OC2=C(C=C(C=C2)F)F | |
| InChIKey | DIIYLGZNZGPXRR-UHFFFAOYSA-N |
FK-3311 is a cell-permeable, orally available inhibitor of cyclooxygenase-2 (COX-2) with potent anti-inflammatory activity. By selectively targeting COX-2, it suppresses prostaglandin synthesis and attenuates downstream inflammatory signaling pathways. Consequently, FK-3311 exerts protective effects against hepatic warm ischemia-reperfusion injury through the marked inhibition of thromboxane A2 production, thereby preserving tissue perfusion and reducing inflammation. [1][2]
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Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
68 mg/mL
(199.22 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 8 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.