CAS No. 24868-20-0
Batch:
Purity:99.33
Chemical Structure
Check the
Dantrolene sodium hemiheptahydrate
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | disodium;bis(3-[(E)-[5-(4-nitrophenyl)furan-2-yl]methylideneamino]-2-oxo-4H-imidazol-5-olate);heptahydrate | |
|---|---|---|
| CAS Number | 24868-20-0 | |
| Molecular Formula |
C14H9N4O5.7/2H2O.Na |
|
| Molecular Weight (MW) | 399.29 | |
| SMILES | C1C(=NC(=O)N1N=CC2=CC=C(O2)C3=CC=C(C=C3)[N+](=O)[O-])[O-].C1C(=NC(=O)N1N=CC2=CC=C(O2)C3=CC=C(C=C3)[N+](=O)[O-])[O-].O.O.O.O.O.O.O.[Na+].[Na+] | |
| InChIKey | LTWQNYPDAUSXBC-CDJGKPBYSA-L |
Dantrolene sodium hemiheptahydrate is a skeletal muscle relaxant that acts as a ryanodine receptor (RyR) antagonist. It interferes with muscle excitation-contraction coupling by selectively inhibiting calcium release from the sarcoplasmic reticulum into the cytoplasm. This blockade attenuates muscle fiber contraction without directly impairing neuromuscular transmission, suppressing intracellular calcium overload and downstream hypermetabolic responses. [1][2]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
14 mg/mL
(35.06 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
- Dantrolene sodium hemiheptahydrate Solubility in DMSO
- Dantrolene sodium hemiheptahydrate Stock Solution
- Dantrolene sodium hemiheptahydrate Storage
- Dantrolene sodium hemiheptahydrate Stability
- Dantrolene sodium hemiheptahydrate Molecular Weight
- Dantrolene sodium hemiheptahydrate SMILES
- Dantrolene sodium hemiheptahydrate Chemical Structure (2D and 3D)
- Dantrolene sodium hemiheptahydrate SDS｜MSDS
Note: Technical data last updated: Sep 1, 2026.