CAS No. 1713240-67-5

Batch: Purity:99.99
Check CoA
Zegocractin (CM-4620) Chemical Structure
Chemical Structure
Check the Zegocractin (CM-4620) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name N-[5-(6-chloro-2,2-difluoro-1,3-benzodioxol-5-yl)pyrazin-2-yl]-2-fluoro-6-methylbenzamide
CAS Number 1713240-67-5
Molecular Formula

C19H11ClF3N3O3
Molecular Weight (MW) 421.76
SMILES CC1=C(C(=CC=C1)F)C(=O)NC2=NC=C(N=C2)C3=CC4=C(C=C3Cl)OC(O4)(F)F
InChIKey QQMKTHUGOQDEIL-UHFFFAOYSA-N

Ordering Information

Biological Activity

Zegocractin (CM-4620) is a small-molecule inhibitor of calcium-release activated calcium (CRAC) channels that selectively blocks Orai1/STIM1-mediated and Orai2/STIM1-mediated calcium currents. By inhibiting CRAC channel-mediated store-operated calcium entry, it attenuates intracellular calcium influx and downstream calcineurin/NFAT signaling pathways. This inhibition subsequently suppresses pro-inflammatory cytokine expression and cellular activation phenotypes associated with hyperactivated calcium signaling. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
🧮 Molarity Calculator

Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 100 mg/mL (237.1 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Aliquotting Service

Free Aliquotting Service

Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.

Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.

Jump to

Note: Technical data last updated: Sep 1, 2026.