CAS No. 491-67-8
| IUPAC Name | 5,6,7-trihydroxy-2-phenylchromen-4-one | |
|---|---|---|
| CAS Number | 491-67-8 | |
| Molecular Formula |
C15H10O5 |
|
| Molecular Weight (MW) | 270.24 | |
| SMILES | C1=CC=C(C=C1)C2=CC(=O)C3=C(O2)C=C(C(=C3O)O)O | |
| InChIKey | FXNFHKRTJBSTCS-UHFFFAOYSA-N |
Baicalein is a natural flavone that functions as a selective inhibitor of cytochrome P450 2C9 (CYP2C9) and lipoxygenase enzymes, including platelet lipoxygenase. By inhibiting lipoxygenase activity and CYP2C9-mediated metabolism, baicalein modulates arachidonic acid signaling pathways and cellular metabolic processes. These mechanisms contribute to downstream cellular phenotypes including attenuation of inflammatory responses and suppression of cellular proliferation. [1][2]
|
Concentration
Volume
Mass
|
|---|
| Solvent | Solubility & Note |
|---|---|
| DMSO |
54 mg/mL
(199.82 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 5 mg/mL |
| Water | Insoluble |
| DMSO |
54 mg/mL
(199.82 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 1 mg/mL |
| Water | Insoluble |
| DMSO |
54 mg/mL
(199.82 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
200 mg/mL
(740.08 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
54 mg/mL
(199.82 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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