Baicalein

Catalog No.S2268 Batch:S226806

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Technical Data

Formula

C15H10O5

Molecular Weight 270.24 CAS No. 491-67-8
Solubility (25°C)* In vitro DMSO 54 mg/mL (199.82 mM)
Water Insoluble
Ethanol Insoluble
In vivo (Add solvents to the product individually and in order)
Clear solution
5%DMSO 45%PEG300 50%ddH2O
10.0mg/ml Taking the 1 mL working solution as an example, add 50 μL of 200 mg/ml clarified DMSO stock solution to 450 μL of PEG 300, mix evenly to clarify it; then continue to add 500 μL of ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results. 
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description Baicalein is a CYP2C9 and prolyl endopeptidase inhibitor.
Targets
CYP2C9 [1]
In vitro

Baicalein robustly inhibits stress-induced hypertrophy, by attenuating p38 signaling and PKD phosphorylation at serine 744/748 (S744/748), and downregulating signal transducer and activator of transcription 3 (STAT3).[2]
In vivo

Baicalein exhibits a protective effect against LPS/D-gal-induced acute liver injury via suppressing NLRP3-mediated pro-inflammatory cytokines production.[3]

Protocol (from reference)

Cell Assay:

[2]
  • Cell lines

    Neonatal rat ventricular myocytes (NRVMs)

  • Concentrations

    10 μM

  • Incubation Time

    48 h

  • Method

    Neonatal rat ventricular myocytes (NRVMs) are stimulated to hypertrophy with phenylephrine (PE;10 M) in the absence or presence of vehicle control (Veh) or phytochemicals (apigenin (Api), baicalein (Bac), berberine hydrochloride (BHCl), emodin (Emod); All compounds are used at 10 μM) for 48 h. RNA is isolated and qPCR performed to analyze the natriuretic peptides (ANP and BNP), interleukins (IL-6, IL-1α, and IL-1β, CXC chemokine ligands (CXCL2 and CXCL6) and CC Chemokine ligands (CCL3 and CCL6).
Animal Study:

[3]
  • Animal Models

    Nlrp3-/- (021302) mice, Gsdmd-/- (032410) mice, C57BL/6J WT mice

  • Dosages

    30 mg/kg

  • Administration

    --

Customer Product Validation

, , Mol Cell Biochem, 2015, 406:111–119.

, , Biochem Biophys Res Commun, 2016, 473(4):775-80.

Data from [Data independently produced by , , Chem Biol Interact, 2018, 285:48-58]

Data from [Data independently produced by , , Int J Biochem Cell Biol, 2018, 94:107-118]

Selleck's Baicalein has been cited by 29 publications

Activity and inhibition of the SARS-CoV-2 Omicron nsp13 R392C variant using RNA duplex unwinding assays [ SLAS Discov, 2024, S2472-5552(24)00007-8] PubMed: 38301954
Glutathione metabolism rewiring protects renal tubule cells against cisplatin-induced apoptosis and ferroptosis [ Redox Rep, 2023, 28(1):2152607] PubMed: 36692085
Baicalein Resensitizes Multidrug-Resistant Gram-Negative Pathogens to Doxycycline [ Microbiol Spectr, 2023, 11(3):e0470222] PubMed: 37070985
Serum myoglobin modulates kidney injury via inducing ferroptosis after exertional heatstroke [ J Transl Int Med, 2023, 11(2):178-188] PubMed: 37408574
Integrative analysis of drug response and clinical outcome in acute myeloid leukemia [ Cancer Cell, 2022, S1535-6108(22)00312-9] PubMed: 35868306
Nao Tan Qing ameliorates Alzheimer's disease-like pathology by regulating glycolipid metabolism and neuroinflammation: A network pharmacology analysis and biological validation [ Pharmacol Res, 2022, 185:106489] PubMed: 36228869
Baicalein modulates mitochondrial function by upregulating mitochondrial uncoupling protein-1 (UCP1) expression in brown adipocytes, cytotoxicity, and computational studies [ Int J Biol Macromol, 2022, S0141-8130(22)02224-3] PubMed: 36252624
Multifocal Organoid Capturing of Colon Cancer Reveals Pervasive Intratumoral Heterogenous Drug Responses [ Adv Sci (Weinh), 2021, e2103360] PubMed: 34918496
pH-dependent rearrangement determines the iron-activation and antitumor activity of artemisinins [ Free Radic Biol Med, 2021, 163:234-242] PubMed: 33359684
Divergent and Overlapping Roles for Selected Phytochemicals in the Regulation of Pathological Cardiac Hypertrophy [ Molecules, 2021, 26(5)1210] PubMed: 33668293

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.