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Elamipretide (SS-31, MTP-131)

Cat.No.S9803

Elamipretide (MTP-131, SS-31) is a cytochrome c peroxidase inhibitor. Elamipretide improves mitochondrial dysfunction, synaptic and memory impairment induced by lipopolysaccharide in mice.

Amino-acid Sequence

Elamipretide (SS-31, MTP-131) Amino-acid Sequence

CAS No. 736992-21-5

Selleck's Elamipretide (SS-31, MTP-131) Has Been Cited by 16 Publications

Quality Control

Batch: Purity: 99.37%
99.37

Chemical Information & Solubility

Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

Water : 100 mg/mL


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In vivo
Batch:

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Biological Activity

Description Elamipretide (MTP-131, SS-31) is a cytochrome c peroxidase inhibitor. Elamipretide improves mitochondrial dysfunction, synaptic and memory impairment induced by lipopolysaccharide in mice.
Targets/IC50/Ki
cytochrome c peroxidase

In vitro
In vitro

Elamipretide (SS-31, MTP-131) binds with high affinity to cardiolipin, an anionic phospholipid expressed on the inner mitochondrial membrane that is required for cristae formation. In addition, the complex of this compound with cardiolipin inhibits cytochrome c peroxidase activity, which catalyzes cardiolipin peroxidation and results in mitochondrial damage during ischemia, by protecting its heme iron.
Cell Research Cell lines feline kidney cells
Concentrations 0.1-10 μM
Incubation Time 1 hour
Method

Intracellular targeting of Elamipretide (SS-31, MTP-131) is determined by incubating feline kidney cells, grown in biotin-free media for 24 hours, with biotinylated compound for 1 hour. Cells are then fixed with 4% paraformaldehyde, permeabilized with 0.1% triton, and treated with Streptavidin-AlexaFluor594 for 30 minutes at room temperature. Fluorescence staining is observed by wide-field fluorescent microscope.

In Vivo
In vivo

Pretreatment of rats with Elamipretide (SS-31, MTP-131) protects cristae membranes during renal ischemia and prevents mitochondrial swelling. Prompt recovery of ATP on reperfusion leads to rapid repair of ATP-dependent processes, such as restoration of the actin cytoskeleton and cell polarity. Rapid recovery of ATP also inhibits apoptosis, protects tubular barrier function, and mitigates renal dysfunction.
Animal Research Animal Models male Sprague–Dawley rats
Dosages 2.0 mg/kg
Administration SC

References
  • https://pubmed.ncbi.nlm.nih.gov/23813215/
  • https://pubmed.ncbi.nlm.nih.gov/31747905/

Product Information

Molecular Formula

C32H49N9O5
Molecular Weight 639.79
CAS No. 736992-21-5
Storage
(From the date of receipt)		 3 years -20°C powder
Shipping Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)