Home Metabolism Antioxidant inhibitor Elamipretide (SS-31, MTP-131)

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Elamipretide (SS-31, MTP-131) Antioxidant peptide

Cat.No.S9803

Elamipretide (MTP-131, SS-31) is a cytochrome c peroxidase inhibitor. Elamipretide improves mitochondrial dysfunction, synaptic and memory impairment induced by lipopolysaccharide in mice.
Elamipretide (SS-31, MTP-131) Antioxidant inhibitor Chemical Structure

Chemical Structure

Molecular Weight: 639.79

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Quality Control

Batch: Purity: 99.37%
99.37

Solubility

In vitro
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Water : 100 mg/mL

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Chemical Information, Storage & Stability

Molecular Weight 639.79 Formula

C32H49N9O5

 Storage (From the date of receipt) 3 years -20°C powder
CAS No. 736992-21-5 -- Storage of Stock Solutions

Synonyms D-Arg-Dmt-Lys-Phe-NH2 Smiles CC1=C(CC(NC(=O)C(N)CCCNC(N)=N)C(=O)NC(CCCCN)C(=O)NC(CC2=CC=CC=C2)C(N)=O)C(=CC(=C1)O)C

Mechanism of Action

Targets/IC50/Ki
cytochrome c peroxidase
In vitro

Elamipretide (SS-31, MTP-131) binds with high affinity to cardiolipin, an anionic phospholipid expressed on the inner mitochondrial membrane that is required for cristae formation. In addition, the complex of this compound with cardiolipin inhibits cytochrome c peroxidase activity, which catalyzes cardiolipin peroxidation and results in mitochondrial damage during ischemia, by protecting its heme iron.
In vivo

Pretreatment of rats with Elamipretide (SS-31, MTP-131) protects cristae membranes during renal ischemia and prevents mitochondrial swelling. Prompt recovery of ATP on reperfusion leads to rapid repair of ATP-dependent processes, such as restoration of the actin cytoskeleton and cell polarity. Rapid recovery of ATP also inhibits apoptosis, protects tubular barrier function, and mitigates renal dysfunction.
References

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05194631 Recruiting
Diaphragm Injury|Mechanical Ventilation Complication
University Hospital Montpellier
 February 18 2022 Not Applicable
NCT02914665 Completed
Heart Failure
Stealth BioTherapeutics Inc.
 October 20 2016 Phase 2
NCT02848313 Completed
Age-Related Macular Degeneration
Stealth BioTherapeutics Inc.
 October 28 2016 Phase 1
NCT02814097 Completed
Chronic Heart Failure
Stealth BioTherapeutics Inc.|Charite University Berlin Germany|SCIRENT Clinical Research and Science d.o.o.
 September 2 2016 Phase 2
NCT02436447 Completed
Normal and Impaired Renal Function
Stealth BioTherapeutics Inc.
 May 2015 Phase 1

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