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Elamipretide (SS-31, MTP-131)

Elamipretide (SS-31, MTP-131) is a cytochrome c peroxidase inhibitor that improves mitochondrial dysfunction, synaptic and memory impairment induced by lipopolysaccharide in mice.

Amino-acid Sequence

Elamipretide (SS-31, MTP-131) Amino-acid Sequence

CAS No. 736992-21-5

Selleck's Elamipretide (SS-31, MTP-131) Has Been Cited by 16 Publications

Purity & Quality Control

Batch: Purity: 99.37%
99.37

Chemical Information & Solubility

Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

Water : 100 mg/mL


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In vivo
Batch:

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Biological Activity

Description Elamipretide (SS-31, MTP-131) is a cytochrome c peroxidase inhibitor that improves mitochondrial dysfunction, synaptic and memory impairment induced by lipopolysaccharide in mice.
Targets
cytochrome c peroxidase

In vitro
In vitro

Elamipretide (SS-31, MTP-131) binds with high affinity to cardiolipin, an anionic phospholipid expressed on the inner mitochondrial membrane that is required for cristae formation. In addition, the complex formed with cardiolipin inhibits cytochrome c peroxidase activity, which catalyzes cardiolipin peroxidation and results in mitochondrial damage during ischemia, by protecting its heme iron.[1]
Cell Research Cell lines feline kidney cells
Concentrations 0.1-10 μM
Incubation Time 1 hour
Method

Intracellular targeting of Elamipretide (SS-31, MTP-131) is determined by incubating feline kidney cells, grown in biotin-free media for 24 hours, with biotinylated SS-31 for 1 hour. Cells are then fixed with 4% paraformaldehyde, permeabilized with 0.1% triton, and treated with Streptavidin-AlexaFluor594 for 30 minutes at room temperature. Fluorescence staining is observed by wide-field fluorescent microscope.

In Vivo
In vivo

Pretreatment of rats with Elamipretide (SS-31, MTP-131) protects cristae membranes during renal ischemia and prevents mitochondrial swelling. Prompt recovery of ATP on reperfusion leads to rapid repair of ATP-dependent processes, such as restoration of the actin cytoskeleton and cell polarity. Rapid recovery of ATP also inhibits apoptosis, protects tubular barrier function, and mitigates renal dysfunction.[1]
Animal Research Animal Models male Sprague–Dawley rats
Dosages 2.0 mg/kg
Administration SC

References
  • https://pubmed.ncbi.nlm.nih.gov/23813215/
  • https://pubmed.ncbi.nlm.nih.gov/31747905/

Product Information

Molecular Formula:

C32H49N9O5
Molecular Weight: 639.79
CAS No.: 736992-21-5
Storage
(From the date of receipt):		 3 years -20°C powder
Shipping: Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)