| S2863 |
Nodinitib-1 (ML130)
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Nodinitib-1 (ML130) is a potent and selective inhibitor of NOD1 with IC50 of 0.56 μM. It inhibits NF-κB activation and exhibits 36-fold selectivity over NOD2.
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Cells, 2023, 12(5)696
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J Neuroinflammation, 2020, 17(1):364
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J Immunol, 2020, 205(3):811-821
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| S0004 |
NOD-IN-1
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NOD-IN-1 (MDK19922, Compound 4) is a potent mixed inhibitor of nucleotide-binding oligomerization domain (NOD)-like receptor 1 (NOD1) and NOD2 with IC50 of 5.74 μM and 6.45 μM, respectively.
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PLoS Pathog, 2023, 19(6):e1011455
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| S0349 |
Inarigivir soproxil
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Inarigivir soproxil (GS 9992, SB 9200) is an oral agonist of innate immunity that is believed to act via the activation of the RIG-I and NOD2 pathways. This compound has broad-spectrum antiviral activity against RNA viruses with EC50 of 2.2 μM and 1.0 μM for HCV 1a and HCV 1b.
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Transl Oncol, 2025, 51:102230
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