Nrf2 Inhibitors

Cat.No.	Product Name	Information	Product Use Citations
S8790	ML385	ML385 is a novel and specific NRF2 inhibitor with an IC50 of 1.9 μM. It inhibits the downstream target gene expression of NRF2. This compound regulates the activity of several ferroptosis and lipid peroxidation-related proteins.	Signal Transduct Target Ther, 2025, 10(1):323 Redox Biol, 2025, 84:103657 EMBO Mol Med, 2025, 10.1038/s44321-025-00293-5
S7956	Brusatol	Brusatol (NSC 172924), isolated from the fruit of B. javanica, is a NRF2 inhibitor.	EMBO Mol Med, 2025, 17(7):1794-1824 J Zhejiang Univ Sci B, 2025, 26(9):881-896 Neurochem Int, 2025, 188:106004
E1141	KI696	KI696 is a potent and selective inhibitor of KEAP1/NRF2 interaction. This compound induces the expression of each of the Nqo1, Ho-1, Txnrd1, Srxn1, Gsta3, Gclc genes in a dose-dependent manner.	Clin Mol Hepatol, 2025, 10.3350/cmh.2024.0948 Chin Med J (Engl), 2025, 138(13):1607-1620 Redox Biol, 2024, 72:103137
E1973	R16	R16(NSC29869, Nrf2-IN-3) is an inhibitor of NRF2 (nuclear factor erythroid 2-related factor 2) that selectively binds KEAP1 mutants and restores their NRF2-inhibitory function by repairing the disrupted KEAP1/NRF2 interactions. It significantly enhances the sensitivity of KEAP1-mutated tumor cells to cisplatin and gefitinib.
E0129	Oxysophocarpine	Oxysophocarpine (OSC) is an alkaloid extracted from Sophora alopecuroides. This compound inhibits the growth and metastasis of oral squamous cell carcinoma (OSCC) by targeting the Nrf2/HO-1 axis. It protects cells against apoptosis and inflammatory responses and compromised miR-155 activity by attenuating MAPK and NF-κB pathways.