Nrf2 Activators

Cat.No.	Product Name	Information	Product Use Citations
S8078	Bardoxolone Methyl (RTA 402)	Bardoxolone Methyl (RTA 402, TP-155, NSC 713200, CDDO Methyl Ester, CDDO-Me) is an IKK inhibitor, showing potent proapoptotic and anti-inflammatory activities; Also a potent Nrf2 activator and nuclear factor-κB (NF-κB) inhibitor. Bardoxolone Methyl abrogates ferroptosis. Bardoxolone methyl induces apoptosis and autophagy in cancer cells.	J Clin Invest, 2025, 135(14)e176655 Redox Biol, 2025, 87:103885 Research (Wash D C), 2025, 8:0980
S5771	Sulforaphane	Sulforaphane is a naturally occurring isothiocyanate derived from the consumption of cruciferous vegetables, such as broccoli, cabbage, and kale. It is an inducer of Nrf2. This compound is also an inhibitor of histone deacetylase (HDAC) and NF-κB. It increases heme oxygenase-1 (HO-1) and reduces the levels of reactive oxygen species (ROS). It induces cell cycle arrest and apoptosis.	J Clin Invest, 2025, 135(14)e176655 Sci Rep, 2025, 15(1):21271 BMC Cancer, 2025, 25(1):1050
S4990	TBHQ	Tert-butylhydroquinone (TBHQ) is an antioxidant compound which is used to prevent lipid peroxidation and shows multiple cytoprotective actions. It is an activator of Nrf2.	Cancer Commun (Lond), 2025, 10.1002/cac2.70036 Mol Med, 2025, 31(1):1 J Zhejiang Univ Sci B, 2025, 26(9):881-896
S2586	DMF (Dimethyl Fumarate)	Dimethyl Fumarate (DMF), the methyl ester of fumaric acid, is used to treat people with relapsing forms of multiple sclerosis. It is a nuclear factor (erythroid-derived)-like 2 (Nrf2) pathway activator and induces upregulation of antioxidant gene expression.	J Clin Invest, 2025, 135(14)e176655 Neural Regen Res, 2025, 10.4103/NRR.NRR-D-24-01469 Chin Med, 2025, 20(1):61
S7864	Oltipraz	Oltipraz is a potent Nrf2 activator and a potent inducer of Phase II detoxification enzymes, most notably glutathione-S-transferase (GST). Phase 3.	Int Immunopharmacol, 2024, 143(Pt 1):113346 J Neuroinflammation, 2023, 20(1):212 PLoS Genet, 2022, 18(3):e1010128
S6647	Bardoxolone (CDDO)	Bardoxolone (CDDO), acts by releasing Nrf2 from KEAP1,is a highly potent activator of Nrf2 that induce programmed cell death (apoptosis) in cancer cells.	J Clin Invest, 2025, 135(14)e176655 Sci Rep, 2025, 15(1):21271 Int J Mol Sci, 2024, 25(15)8046
S5929	4-Octyl Itaconate	4-Octyl Itaconate activates Nrf2 signaling to inhibit the production of pro-inflammatory cytokines in human macrophages and systemic lupus erythematosus (SLE) patient-derived PBMCs.	Clin Transl Med, 2025, 15(7):e70419 Biochem Biophys Res Commun, 2025, 747:151292 Cell Death Dis, 2022, 13(6):521
S9723	CDDO-Im (RTA-403)	An activator of nuclear factor erythroid 2–related factor 2 (Nrf2) and peroxisome proliferator-activated receptor (PPAR), CDDO-Im (RTA-403) binds to PPARα and PPARγ with Ki of 232 nM and 344 nM, respectively. It inhibits inflammatory response and tumor growth in vivo.	Ecotoxicol Environ Saf, 2022, 241:113754 Int J Mol Sci, 2022, 23(19)11715
S3168	cis-Resveratrol	cis-Resveratrol (cis-RESV, cRes, (Z)-Resveratrol) is the Cis isomer of Resveratrol. Resveratrol is a natural phenolic compound with anti-oxidant, anti-inflammatory, cardioprotective, and anti-cancer properties. Resveratrol is an inhibitor of pregnane X receptor (PXR) and an activator of Nrf2 and SIRT1 and may induce apoptosis. Resveratrol also inhibits a wide spectrum of targets including 5-lipoxygenase (LOX), cyclooxygenase (COX), IKKβ, DNA polymerases α and δ with IC50 of 2.7 μM, <1 μM, 1 μM, 3.3 μM and 5 μM, respectively.	J Gerontol A Biol Sci Med Sci, 2022, 77-8:1485-1493
S3808	Mangiferin	Mangiferin (Alpizarin, Chinomin, Hedysarid) is a bioactive compound that demonstrates many health perspectives and has been used to prepare medicinal and food supplements. This compound is a Nrf2 activator. It suppresses nuclear translocation of the NF-κB subunits p65 and p50.	Front Pharmacol, 2022, 13:1028932
E0441	NK-252	NK-252 is an activator of Nrf2 and interacts with the Nrf2-binding site of Keap1.
E1220	CBR-470-1	CBR-470-1 is an inhibitor of the glycolytic enzyme phosphoglycerate kinase 1 (PGK1). This compound is also a non-covalent Nrf2 activator. It protects SH-SY5Y neuronal cells against MPP+-induced cytotoxicity through activation of the Keap1-Nrf2 cascade.
E0023	5,7-Dihydroxychromone	5,7-Dihydroxychromone (DHC), a natural antioxidant extracted from plants, is a potent activator of Nrf2/ARE signal. This compound also is a potent activator of PPARγ and LXRα. It may contributes to regulate blood glucose levels and shows anti-diabetic property.
E4007	L-Sulforaphane	L-Sulforaphane ((R)-Sulforaphane) is a highly potent inducer of the Keap1/Nrf2/ARE pathway. It is a more potent inducer of the carcinogen-detoxifying enzyme systems in rat liver and lung than the S-isomer.
S1848	Curcumin	Curcumin (Diferuloylmethane, Natural Yellow 3, Turmeric yellow) is the principal curcuminoid of the popular Indian spice turmeric, which is a member of the ginger family (Zingiberaceae). It is an inhibitor of p300 histone acetylatransferase（IC50~25 μM）and Histone deacetylase (HDAC); activates Nrf2 pathway and supresses the activation of NF-κB. Curcumin induces mitophagy, autophagy, apoptosis, and cell cycle arrest with antitumor activity. Curcumin reduces renal damage associated with rhabdomyolysis by decreasing ferroptosis-mediated cell death. Curcumin exhibits anti-infective properties against various human pathogens like the influenza virus, hepatitis C virus, HIV and so on.	J Biol Chem, 2025, 301(7):110305 Mol Pain, 2025, 21:17448069251323668 BMC Immunol, 2025, 26(1):67
S7672	Omaveloxolone (RTA-408)	Omaveloxolone (RTA-408) is a synthetic triterpenoid that activates the cytoprotective transcription factor Nrf2 and inhibits NF-κB signaling. Phase 2.	J Clin Invest, 2025, 135(14)e176655 Redox Biol, 2025, 87:103885 Front Pharmacol, 2025, 16:1539032
S3275	Senkyunolide I	Senkyunolide I (SEI, SENI) is an orally active compound isolated from Ligusticum chuanxiong with analgesic, anti-migraine, neuroprotective, anti-oxidation and anti-apoptosis activities. This compound up-regulates the phosphorylation of Erk1/2 and induces Nrf2 nuclear translocation with enhanced HO-1 and NQO1 expressions. It also promotes the ratio of Bcl-2/Bax and inhibits the expressions of cleaved caspase 3 and caspase 9.	Blood Sci, 2025, 7(3):e00246 iScience, 2024, 27(7):110367 World J Emerg Med, 2024, 15(3):206-213
S5144	Neferine	Neferine ((R)-1,2-Dimethoxyaporphine), a natural component of Nelumbo nucifera, has antitumor efficiency. It induces apoptosis in renal cancer cells. This compound prevents autophagy through activation of Akt/mTOR pathway and Nrf2 in muscle cells. It strongly inhibits NF-κB activation. It possesses a number of therapeutic effects such as anti-diabetic, anti-aging, anti-microbial, anti-thrombotic, anti-arrhythmic, anti-inflammatory and even anti-HIV.	J Cosmet Dermatol, 2024, 10.1111/jocd.16587 Bone Res, 2022, 10(1):27 Cell Death Dis, 2022, 13(11):1000
S3784	Obacunone (AI3-37934)	Obacunone (AI3-37934, CCRIS 8657), a natural compound present in citrus fruits, has been demonstrated for various biological activities including anti-cancer and anti-inflammatory properties. This compound significantly inhibits aromatase activity in an in vitro enzyme assay with an IC50 value of 28.04 μM; it is also a novel activator of Nrf2.	Int J Mol Sci, 2023, 24(14)11484 University of Valencia, 2023, Cell Mol Biol Lett, 2022, 27(1):29
S3301	Cynarin	Cynarin (Cynarine) is an artichoke phytochemical that possesses a variety of pharmacological features including free-radical scavenging, antioxidant, antihistamic and antiviral activities. This compound blocks the interaction between the CD28 of T-cell receptor and CD80 of antigen presenting cells. It triggers Nrf2 nuclear translocation, restores the balance of glutathione (GSH) and reactive oxygen species (ROS), and inhibits mitochondrial depolarization.	Int J Mol Med, 2025, 56(6)206
S3205	Perillaldehyde	Perillaldehyde (Perilladehyde, Perillal, PAE, PA), the main component of Perilla frutescens (a traditional medicinal antioxidant herb), inhibits BaP-induced AHR activation and ROS production, inhibits BaP/AHR-mediated release of the CCL2 chemokine, and activats the NRF2/HO1 antioxidant pathway.	Front Cell Dev Biol, 2025, 13:1598520
S4712	Diethylmaleate	Diethylmaleate (Diethyl ester, Maleic acid diethyl ester) is the diethyl ester of maleic acid and a glutathione-depleting compound that inhibits NF-κB.