Immunology & Inflammation related Inhibitors

Cat.No.	Product Name	Information	Product Use Citations
S3032	Bindarit (AF 2838)	Bindarit exhibits selective inhibition against monocyte chemotactic proteins MCP-1/CCL2, MCP-3/CCL7 and MCP-2/CCL8.	Exp Mol Med, 2024, 56(2):408-421. PLoS Pathog, 2024, 20(11):e1012747 J Biol Chem, 2023, S0021-9258(23)02393-1
S1576	Sulfasalazine	Sulfasalazine is a sulfa derivative of mesalazine, used as an anti-inflammatory agent to treat bowel disease and rheumatoid arthritis. This compound is a potent and specific inhibitor of nuclear factor kappa B (NF-κB), TGF-β and COX-2. It induces ferroptosis, apoptosis and autophagy.	Med Oncol, 2024, 41(8):188 Adv Sci (Weinh), 2023, 10(20):e2300517 Proc Natl Acad Sci U S A, 2022, 119(36):e2117396119
S5004	Pimecrolimus	Pimecrolimus (Elidel,ASM 981,SDZ-ASM 981) is an immunophilin ligand, which binds specifically to the cytosolic receptor, immunophilin macrophilin-12 (FKBP-12); a calcineurin inhibitor.	iScience, 2024, 27(10):110862 J Pers Med, 2022, 12(2)258 Hum Cell, 2022, 10.1007/s13577-022-00671-y
S1591	Bestatin (Ubenimex)	Bestatin (Ubenimex) is a potent aminopeptidase-B and leukotriene (LT) A4 hydrolase inhibitor, used in the treatment of acute myelocytic leukemia.	Cell Rep, 2024, 43(4):114041 Cell Reports, 2024, 114041 iScience, 2024, 27(10):110862
S8660	GI254023X (GI4023)	GI254023X (GI 4023, SRI028594) is a selective inhibitor of ADAM10 with 100-fold selectivity for ADAM10 over ADAM17. The IC50 values for recombinant ADAM10 amd ADAM17 are 5.3 nM and 541 nM, respectively.GI254023X can inhibit MMP9.	Signal Transduct Target Ther, 2025, 10(1):387 Cell Death Dis, 2025, 16(1):34 Alzheimers Res Ther, 2024, 16(1):160
S1654	Phenylbutazone	Phenylbutazone (Butazolidine) is used as a non-steroidal anti-inflammatory agent for the treatment of chronic pain, including the symptoms of arthritis.	Communications Medicine, 2025, 420 iScience, 2024, 27(10):110862 J Pers Med, 2022, 12(2)258
S8291	Atractylenolide I	Atractylenolide I is the major sesquiterpenoid of the rhizome of A. macrocephala and shows a wide spectrum of pharmacological activities such as antiinflammatory, digestion promoting, and antioxidant effects.	Front Oncol, 2021, 11:738534 Mol Med Rep, 2021, 24(4)691 Front Pharmacol, 2020, 26;11:273
S9032	Sanguinarine	Sanguinarine (Pseudochelerythrine, Sanguinarin, Sanguinarium), a benzophenanthridine alkaloid known as an anti-inflammatory agent, is a potent inhibitor of NF-κB activation.	Cell Mol Life Sci, 2025, 82(1):311 J Clin Biochem Nutr, 2025, 77(1):37-44 Front Oncol, 2022, 12:732860
S6812	Z-Guggulsterone	Z-Guggulsterone, a constituent of Ayurvedic medicinal plant Commiphora mukul, inhibits angiogenesis in vitro and in vivo. This compound exhibits anti-inflammatory effects in microglia. It induces apoptosis in gastric cancer cells through the intrinsic mitochondria-dependent pathway.	Journal of Animal Science and Biotechnology, 2025, Article number: 16 International Journal of Biological Sciences, 2023, 3456-3471 Int J Biol Sci, 2023, 19(11):3456-3471
S3608	Demethylzeylasteral (T-96)	An active component isolated from Tripterygium wilfordii Hook F., Demethylzeylasteral (T-96) inhibits UDP-glucuronosyltransferase (UGT) isoforms UGT1A6 and UGT2B7 with immunosuppressive effects.	J Cancer, 2025, 16(1):227-240 J Cancer, 2021, 12(13):3967-3975 Front Biosci (Landmark Ed), 2020, 25:498-512
S4268	Flufenamic acid	Flufenamic Acid is an anti-inflammatory agent, and also acts as an ion channel modulator.	Theranostics, 2022, 12(18):7681-7698 Theranostics, 2022, 7681-7698 Biochim Biophys Acta Mol Cell Biol Lipids, 2020, 1865(12):158793
S6239	PMX-53	PMX-53 is a potent CD88 (C5aR) antagonist and inhibits C5a-induced neutrophil myeloperoxidase release and chemotaxis with IC50 values of 22 nM and 75 nM, respectively. This compound is also an agonist of Mas-related gene 2 (MrgX2).	Redox Biol, 2025, 86:103802 Biomolecules, 2025, 15(8)1106 Thromb J, 2022, 20(1):24
S3758	Sinomenine hydrochloride	Sinomenine (SN, Cucoline, Kukoline, Sabianine A), extracted from the Chinese medicinal plant, sinomenium acutum, is a potent anti-inflammatory and neuroprotective agent.	Biomed Res Int, 2022, 2022:4914005 Cancer Manag Res, 2021, 13:1189-1204 Bioorg Med Chem, 2020, 31:115986
S0836	TMN355	TMN355 (Compound 3i) is a potent inhibitor of cyclophilin A (CypA) with IC50 of 1.52 nM and reduces foam cell formation and cytokine secretion. This compound is used for the treatment of atherosclerosis.	Nat Cell Biol, 2024, 10.1038/s41556-024-01387-x Nature Cell Biology, 2024, 593–603 Cell Reports Medicine, 2021, 100186
S3622	Diammonium Glycyrrhizinate	Diammonium glycyrrhizinate (DG), a traditional Chinese medicine (TCM), is extracted and purified from liquorices (Radix glycyrrhizae). It is known for its anti-inflammatory effects, resistance to biologic oxidation and membranous protection. DG is able to reduce inflammatory injury via suppression of NF‑κB, TNF‑α and intercellular adhesion molecule 1.	Int J Mol Sci, 2025, 26(13)6334 International Journal of Molecular Sciences, 2025, 6334
E0365	Fucoidan	Fucoidan is an anionic sulfated polysaccharide extracted from marine brown algae with a large range of biological activities, including anti-inflammatory, anti-cancer, anti-viral, anti-oxidation, anticoagulant, antithrombotic, anti-angiogenic and anti-Helicobacter pylori, etc.	Signal Transduct Target Ther, 2025, 10(1):171 Int J Biol Macromol, 2024, 276(Pt 1):133792
E0206	Ginkgetin	Ginkgetin is a biflavone from Ginkgo biloba leaves with anti-cancer, anti-inflammatory, anti-microbial, anti-adipogenic, and neuroprotective activities.	Scientific Reports, 2025, 1542 Biomed Pharmacother, 2022, 154:113628
S5466	Saikosaponin A	Saikosaponin A is a triterpene saponin derived from the medicinal plant, Bupleurum chinensis DC. (Umbelliferae). It has a variety of pharmacological benefits, including anti-inﬂammatory, immunomodulatory, and anti-bacterial activities.	ACS Applied Materials & Interfaces, 2025, Online ahead of print Phytomedicine, 2024, 133:155944
S5661	Tiaprofenic acid	Tiaprofenic acid (Tiaprofensaeure, Acido tiaprofenico) is a non-steroidal anti-inflammatory drug used to treat pain, especially arthritic pain.	Antiviral Res, 2023, 216:105674
S9055	Salvianolic acid A	Salvianolic acid A (Dan Phenolic Acid A), a water-soluble compound extracted from Radix Salvia miltiorrhiza (Danshen), is an antioxidant and free radical scavenging compound that also acts as an inhibitor of the protein-protein interaction mediated by SH2 domains of Src-family kinases Src and Lck.	Clin Exp Pharmacol Physiol, 2021, 48(4):508-514
S9148	Peiminine	Peiminine (Verticinone, Zhebeinone, Raddeanine), a biologically active component extracted from Fritillaria walujewii Regel, has been reported to have potent anti-inflammatory, antitussive, and expectorant effects. It induces autophagic cell death thus represses colorectal carcinoma tumor growth.	Chem Biol Interact, 2025, 405:111312
S2512	Tenoxicam	Tenoxicam(Ro-12-0068) is a good HO. radicals scavenger with an IC50 of 56.7 μM.
S5361	Bendazac	Bendazac (bendazolic acid, AF-983) is a non-steroidal anti-inflammatory drug that delays the cataractogenic process. It may act by preventing protein denaturation.
E3530	Boat-fruited sterculia seed Extract	Boat-Fruited Sterculia Seed Extract is extracted from the seeds of boat-fruited sterculia, which has an inhibitive effect on acute inflammation.
E3824	Scepteridium Ternatum Extract	Scepteridium Ternatum Extract is extracted from Scepteridium ternatum, which is used for the treatment of asthma.
E3829	Epimedium Brevicornu Extract	Epimedium Brevicornu Extract is extracted from Epimedium brevicornu Maxim, which has anti-inflammatory effects.
E1519^New	DB2313	DB2313 is a potent inhibitor of the transcription factor PU.1, effectively blocking PU.1-dependent reporter gene transactivation with an IC50 of 5 μM. This compound demonstrated significant anti-leukemic activity by inducing apoptosis in acute myeloid leukemia (AML) cells. It also increases survival rates and reduces tumor burden in vivo.
E3834	Jasminum Nudiflorum Extract	Jasminum Nudiflorum Extract is extracted from Jasminum nudiflorum, which helps in treating dermatosis, coryza, nasal haemorrhage, infections, and wounds.
E3839	Houttuynia Cordata Extract	Houttuynia Cordata Extract is extracted from Houttuynia cordata, which ameliorates bladder damage and improves bladder symptoms via anti-inflammatory effects.
E3840	Ulmus Pumila Bark Extract	Ulmus Pumila Bark Extract is extracted from the bark of Ulmus pumila L., which prevents inflammatory diseases mediated by excessive production of nitric oxide.
E8285^New	Certepetide	Certepetide is a cyclic peptide that enhances delivery of coadministered anticancer drugs and modulates the tumor microenvironment. It binds αvβ3/5-integrins on tumor endothelium, undergoes proteolytic cleavage, and the resulting fragment binds neuropilin-1, triggering active tumor-specific drug transport. It also depletes immunosuppressive T cells, enhances cytotoxic T cells, and inhibits metastasis.
E3554	Rhizoma homalomenae Extract	Rhizoma Homalomenae Extract is extracted from Rhizoma Homalomenae, which has anti-inflammatory activity.
E3555	Acmella oleracea Extract	Acmella Oleracea Extract is extracted from Acmella Oleracea, which can decrease chymase activity, oxidative stress, and inflammation.
E7240	7,4'-Dihydroxyflavone	7,4'-Dihydroxyflavone (7,4'-DHF) is a flavonoid isolated from Glycyrrhiza uralensis that acts as a potent inhibitor of eotaxin/CCL11 and CBR1 with an IC50 of 0.28 μM. It consistently suppresses eotaxin production and dexamethasone paradoxical adverse effect on eotaxin production in human lung fibroblasts. It also decreases PMA-stimulated MUC5AC gene expression and mucus production in NCI-H292 human airway epithelial cells with an IC50 of 1.4 μM.
S9033	Incensole acetate	Incensole acetate, isolated from Boswellia Resin, is a novel anti-inflammatory compound that inhibits NF-κB activation.
E3074	Xanthium Sibiricum Extract	Xanthium Sibiricum Extract is extracted from Xanthium Sibiricum, which has anti-inflammatory activity.
E3559	Radix rubiae Extract	Radix Rubiae Extract is extracted from Rubia cordifolia, which has anti-tumor, anti-oxidative, anti-platelet aggregation, and anti-inflammatory effects.
E3852	Oenothera Biennis Extract	Oenothera Biennis Extract is extracted from Oenothera biennis L., which has high anti-inflammatory properties.
E3853	Blueberry Fruit Extract	Blueberry Fruit Extract is extracted from the fruits of Vaccinium, which helps in maintenance of blood sugar levels, reduction of oxidative stress, anti-inflammatory effect, prevention of cardiovascular diseases, antimicrobial and antitumoural activity.
E3854	Coriolus Versicolor Extract	Coriolus Versicolor Extract is extracted from Coriolus versicolor, which possesses cytotoxic activity against cancer cells and endothelial cells and has the ability to inhibit the expression of the pro-tumorigenic factors associated with inflammation.
E3564	Celery Extract	Celery Extract is extracted from Apium graveolens, which has suppressive effect on PMA/ionomycin mediated CD4+ T lymphocyte activation.
E3565	Celery seed Extract	Celery Seed Extract is extracted from the seed of Apium graveolens, which has suppressive effect on PMA/ionomycin mediated CD4+ T lymphocyte activation.
E3567	Ash bark Extract	Ash Bark Extract is extracted from the bark of Fraxinus chinensis, which has anti-Inflammatory effect.
E3860	Euphorbia Helioscopia Extract	Euphorbia Helioscopia Extract is extracted from Euphorbia helioscopia L., which has been used in the treatment of various diseases, including edema, phlegm and cough, malaria, dysentery, scab, tuberculous fistula, osteomyelitis, and cancer.
E3570	Artemisia annua Extract	Artemisia Annua Extract is extracted from Artemisia Annua, which has antimalarial and anticancer effects.
E5969^New	AZD2389	AZD2389 is a potent, orally active, and selective inhibitor of fibroblast activation protein (FAP) with the potential to treat metabolic dysfunction-associated steatohepatitis.
E3188	Cissus Quadrangularis Extract	Cissus Quadrangularis Extract is extracted from Cissus quadrangularis, which is used in the treatment of osteoporosis, asthma, haemorrhoids, and menstrual disorders.
E3867	Fritillariae Thunbergii Bulbus Extract	Fritillariae Thunbergii Bulbus Extract is extracted from Fritillariae thunbergii bulbus, which is used to treat symptoms of cough and airway congestion in the chest due to pathological colds and damp phlegm.
E3875	Unripe Bitter Orange Extract	Unripe Bitter Orange Extract is extracted from the bitter fruit of citrus unshiu, which is an effective anti-allergic functional food.
E3099	Fritillaria Cirrhosa Seed Extract	Fritillaria Cirrhosa Seed Extract is extracted from the seeds of Fritillaria Cirrhosa, which is famous for its antitussive, expectorant, anti-asthma and anti-inflammatory properties, and is widely used to treat respiratory diseases.
E3878	Stalactitum Extract	Stalactitum Extract is extracted from Stalactitum, which can be used as an anti-asthmatic.
E3879	Glabrous Sarcandra Herb Extract	Glabrous Sarcandra Herb Extract is extracted from Sarcandra glabra (Thunb.), which has been applied to treat sore throats, abscesses, and even tumors.
S8091	25-Hydroxycholesterol	25-Hydroxycholesterol is a side-chain oxysterol and a selective suppressor of IgA production by B cells with an EC50≈65 nM. It affects the immune system and has a key role in the pathogenesis of atherosclerosis.
E3890	Lithospermum Erythrorhizon Extract	Lithospermum Erythrorhizon Extract is extracted from Lithospermum erythrorhizon, which has an anti-inflammatory response in bronchial epithelial cells.
E3892	Viola Philphica Munda Extract	Viola Philphica Munda Extract is extracted from Viola philphica munda, which contains polysaccharide and anodyne (has pain-killing strength) and is a diuretic.
E3894	Ardisia Japonica Extract	Ardisia Japonica Extract is extracted from Ardisia japonica, which is used in the treatment of coughs and to stop uterine bleeding.
E0020	Lupenone	Lupenone (Lup-20(29)-en-3-one, lupeone) is an isolated compound exhibiting anti-oxidative, anti-inflammation, and anti-diabetic activities. This compound can protect SH-SY5y cells against METH-induced neuronal apoptosis through the PI3K/Akt pathway.
E3247	Hainan Nightshade Fruit Extract	Hainan Nightshade Fruit Extract is extracted from the fruit of Hainan Nightshade, which has immunity-boosting powers and pain-eliminating abilities since it reduces inflammation and swelling in the body.
S3501	Perflubron	Perflubron (1-Bromoperfluorooctane, Perfluorooctyl bromide, Oxygent, PFOB) exhibits anti-inflammatory activity thus decreases cytokine production in human alveolar macrophages. This compound also attenuates oxidative damage to both biological and nonbiological systems which is independent of its anti-inflammatory properties.
S3500	Pentosan Polysulfate Sodium	Pentosan Polysulfate Sodium (PPS, Elmiron) is an orally bioavailable, semi-synthetic medication with anti-inflammatory and pro-chondrogenic properties. This compound also exhibits anti-HIV-1 activity.
E3898	Radix Asteris Extract	Radix Asteris Extract is extracted from the root and rhizome of Aster tataricus L. f., which has been used to treat cough and asthma.
E3217	Penthorum Chinense Pursh Extract	Penthorum Chinense Pursh Extract is extrcated from Penthorum Chinense Pursh, which is used in the treatment of traumatic injury, edema, and liver diseases.
E3283	Red Bean Extract	Red Bean Extract is extracted from Red Beans, which possess various functional properties, such as anti-diabetes, anti-aging, anti-inflammatory, anticancer, and hepatoprotective activities.
E3358	Rhizoma Fagopyri Dibotryis Extract	Rhizoma Fagopyri Dibotryis Extract is extracted from Rhizoma Fagopyri Dibotryis, which is used in the treatment of acute lung injury.
E3288	Red Raspberry Extract	Red Raspberry Extract is extracted from Rubus idaeus, which is rich in bioactive components that plays a role in reduction oxidative stress.
E3289	Knoxia Valerianoides Extract	Knoxia Valerianoides Extract is extracted from Knoxia Valerianoides, which along with other herbs can be used for detoxification and treating cancer and inflammatory diseases.
E3366	Fineleaf Schizonepeta Herb Extract	Fineleaf Schizonepeta Herb Extract is extracted from the leaves of Schizonepeta, which is used as a traditional medicine with antipyretic, anti-inflammatory, analgesic, and hemostatic effects.
E3346	Oriental Paperbush flower Extract	Oriental Paperbush flower Extract is extracted from the flowers of Edgeworthia chrysantha, which might serve as a potential drug for osteolytic diseases such as osteoporosis.
E3294	Piper Nigrum Seed Extract	Piper Nigrum Seed Extract is extracted from Piper nigrum L., which has antimicrobial activity, antioxidant effects, antidiabetic activity, hypolipidemic activity, anti-inflammatory, analgesic, anticonvulsant, and neuroprotective effects.
E0119	LNP023 (Iptacopan) Hydrochloride	Iptacopan (LNP023) Hydrochloride is a first-in-class, orally administered, potent and highly selective factor B inhibitor with an IC50 of 12 nM and a Kd value of 7.9 nM. Iptacopan exhibits excellent selectivity over other proteases affording IC50s of >30 μM across a panel of 41 human proteases.
E3298	Viscum Coloratum Extract	Viscum Coloratum Extract is extracted from Viscum Coloratum, which is used in the therapy of inflammatory diseases.
E3352	Radix Tinosporae Extract	Radix Tinosporae Extract is extracted from Radix Tinosporae, which is a traditional Chinese medicine for the treatment of various inflammatory diseases.
E3574	Cyclocarya paliurus Extract	Cyclocarya Paliurus Extract is extracted from Cyclocarya Paliurus, which has anti-fibrotic activity.
E3382	Camu Camu fruit Extract	Camu Camu fruit Extract is extracted from the fruit of Myrciaria dubia McVaugh (Myrtaceae), which helps in preventing oxidative stress and skin inflammation induced by high glucose levels.
E3389	Sophora alopecuroides seed Extract	Sophora Alopecuroides Seed Extract is extracted from the seeds of Sophora alopecuroides, which has anti-inflammatory activities.
S9064	Trilobatin	Trilobatin (P-Phlorizin), a natural flavonoid lipid molecule, is an HIV-1 entry inhibitor targeting the HIV-1 Gp41 envelope and exihibits anti-oxidant and anti-inflammatory effect.
E3589	Evodia Lepta Bark Extract	Evodia Lepta Bark Extract is extracted from the bark of Melicope pteleifolia, which has anti-inflammatory activity.
E1134	ABR-238901	ABR-238901 is a novel S100A8/A9 blocker that potently inhibits S100A8/A9 interaction with its receptors RAGE (receptor for advanced glycation endproducts) and TLR4 (toll-like receptor 4).
E1386	KP-457	KP-457 (TNF-α-converting enzyme) is a selective inhibitor of ADAM17 with IC50 of 11.1 nM/L (cell-free assay). It also cleaves various molecules such as GPIbα, GPV, and TNF-α.
S9072	Sweroside	Sweroside, a bioactive herbal ingredient isolated from Fructus Corni, exhibits diverse biological activities, such as anti-fungal, anti-diabetic, anti-inflammatory, and anti-tumor effects.
E3596	Phellinus linteus Extract	Phellinus Linteus Extract is extracted from Phellinus Linteus, which has immunomodulatory effect.
E3658	Double coptis chinensis Extract	Double Coptis Chinensis Extract is extracted from Double Coptis Chinensis, which has antipyretic and anti-inflammatory mechanism.
E3578	Fringed pink Extract	Fringed Pink Extract is extracted from Dianthus superbus, which has anti-inflammatory activity.
E3418	Rhizoma Anemones Raddeanae Extract	Rhizoma Anemones Raddeanae Extract is extracted from the rhizome of Anemone raddeana Regel, which is used to treat wind and cold symptoms, hand-foot disease and spasms, joint pain, and ulcer pain.
S4753	Ganoderic acid A	Ganoderic Acid A (GAA) is an active triangle compound in Ganoderma Lucidum. It can inhibit the JAK-STAT3 signal pathway and inhibit cell proliferation, vitality, and ROS. Ganoderic Acid A has analgesic, antioxidant, cytotoxicity, protecting liver and anti -tumor activity.
E3426	Piper betle L. Extract	Piper Betle L. Extract is extracted from Piper betel l., which is a potential source of wound healing agents.
E3440	Tamarindus indica seed Extract	Tamarindus indica seed Extract is extracted from the seeds of Tamarindus indica, which helps to reduce inflammation and inflammation-induced cartilage degeneration.
E3149	Pheretima Extract	Pheretima Extract is extracted from Pheretima, which has effects on various inflammatory diseases such as asthma, cough, and fever.
E3445	Hibiscus sabdariffa flower Extract	Hibiscus sabdariffa flower Extract is extracted from the flowers of Hibiscus sabdariffa, which enhances anti-inflammatory effects by increasing expression of anti-inflammatory cytokines and decreasing pro-inflammatory cytokines.
E3446	Chinese Starjasmine stem Extract	Chinese Starjasmine Stem Extract is extracted from the stem of Trachelospermum jasminoides, which is used in the treatment of inflammation-related diseases.
E4781	OPN expression inhibitor 1	OPN Expression Inhibitor 1 (Compound 11) is a DHA ether derivative containing a 1,2,3-triazole ring that effectively inhibits osteopontin (OPN) expression. It exhibits significant potential as an anticancer agent by specifically targeting OPN, a key factor in breast cancer progression and metastasis.
E3157	Erycibes Caulis Extract	Erycibes Caulis Extract is extracted from Erycibes Caulis, which is used in the treatment of rheumatoid arthritis.
E3487	Ecliptae Herba Extract	Ecliptae Herba Extract is extracted from Eclipta, which has an anti-osteoporotic effect.
E3492	Vitex negundo seed Extract	Vitex Negundo Seed Extract is extracted from the fruits of Vitex negundo, which is used in the treatment of rheumatism and joint inflammation.
E3494	Oyster Shell Extract	Oyster Shell Extract is extracted from the shell of Ostreidae, which has an anti-inflammatory effect.
E0131	Luteolin-7-O-glucuronide	Luteolin-7-O-glucuronide (Luteolin 7-glucuronide) is a flavone glycoside found in plants. This compound possesses anti-microbial, antioxidant, anti-mutagenic, anti-genotoxic, anti-inflammatory, and anti-arthritic activities.
E3476	Myrrh Extract	Myrrh Extract is extracted from Commiphora myrrha, which is used in the therapy of inflammatory bowel diseases.
S5360	Diflorasone	Diflorasone acts as a corticosteroid hormone receptor agonist with anti-inflammatory and immunosuppressive properties.
S5412	Loxoprofen Sodium	Loxoprofen sodium is a non-steroidal anti-inflammatory drug.
E7425	Alagebrium chloride	Alagebrium chloride is a breaker of AGE-based cross-links that targets and cleaves preformed AGE-derived protein cross-links to reduce tissue stiffness and organ damage. It also inhibits neointimal proliferation in a streptozotocin (STZ)-induced diabetic rat carotid artery balloon injury model.
E0148	Linalyl Acetate	Linalyl Acetate (Bergamiol, Bergamol, Linalool acetate) is a naturally occurring phytochemical found in many flowers and spice plants. This compound is a potentially anti-inflammatory agent.
E0780	MNITMT	MNITMT is a more potent immunosuppressive agent without bone marrow toxicity.
S2286	Cyclosporin A	Cyclosporin A, a non-polar cyclic oligopeptide, is an immunosuppressive agent that binds to cyclophilin and then inhibits calcineurin with IC50 of 7 nM in a cell-free assay. Cyclosporin A is generally given following transplant surgery to prevent rejection and has been used to test its toxic effect on a perfused 3D proximal tubule model.Cyclosporin A (NSC 290193) can be used to induce animal models of Chronic Rejection of Liver Transplantation.	Signal Transduct Target Ther, 2025, 10(1):81 Signal Transduct Target Ther, 2025, 10(1):167 Adv Sci (Weinh), 2025, 12(36):e06150
S7434	TAPI-1	(S,S)-TAPI-1 is an isomer of TAPI-1. TAPI-1 is an ADAM17/TACE inhibitor, which blocks shedding of cytokine receptors. TAPI-1 is also an inhibitor of Matrix Metalloproteinase (MMP).	Nat Sci Sleep, 2025, 17:1915-1928 Br J Cancer, 2024, 10.1038/s41416-024-02576-z J Biol Chem, 2024, 300(12):107930
S1514	Cyclosporine	Cyclosporine is a calcineurin phosphatase pathway inhibitor, used as an immunosuppressant drug to prevent rejection in organ transplantation.	J Adv Res, 2024, S2090-1232(24)00499-5 Cells, 2023, 12(23)2696 Int J Mol Sci, 2023, 24(11)9708
S1622	Prednisone	Prednisone is a synthetic corticosteroid agent that is particularly effective as an immunosuppressant compound.	Chin Med, 2025, 20(1):135 Bangladesh Journal of Pharmacology, 2024, 73-80 Blood Cancer J, 2022, 12(3):36
S9920	GYY4137	GYY4137 is a novel, water-soluble hydrogen sulfide (H2S)–releasing molecule with vasodilator and antihypertensive activity. GYY4137 shows potent anti-hepatocellular carcinoma activity through blocking the STAT3 pathway. GYY4137 also shows anti-inflammatory activity.Stock solutions should be stored under nitrogen, sealed.	Redox Biol, 2025, 85:103736 Stem Cell Res Ther, 2025, 16(1):603 Life Metab, 2025, 4(3):loaf009
S9090	Corilagin	Corilagin, discovered in many medicinal plants such as Phyllanthus speices etc., has multiple activities including anti-oxidative, anti-inflammatory, anti-apoptotic, hepatoprotective and others. It is an inhibitor of TNF-α.	Int Immunopharmacol, 2025, 163:115245 Journal of Chemical Information and Modeling, 2021, 6094-6106
E0150	Carrageenan	Carrageenan (kappa-Carrageenan) is a natural carbohydrate (polysaccharide) obtained from edible red seaweeds. This compound shows anticoagulant activity, antithrombotic activity, antiviral activity, anti-tumour activity and immunomodulatory activity. It can be used to induce animal models of Prostatitis.
S0920	Ginkgolide J	Ginkgolide J is a minor constituent of terpene trilactone mixture of Ginkgo biloba leaves extract that inhibits GlyR-operated channels with IC50 of 2.0 μM. This compound also inhibits cell death of rodent hippocampal neurons caused by Aβ1–42. It exhibits anti‑inflammatory activity.
S0947	Cafestol	Cafestol is a natural diterpenes extracted from coffee beans. It induces apoptosis and regulates a variety of inflammatory mediators to reduce inflammation. This compound inhibits the PI3K/Akt pathway and can also reduce the production of ROS in the leukemia cell line HL60.
E0022	Ophiopogonin D	Ophiopogonin D (OJV-VI, Deacetylophiopogonin C) is a steroidal glycoside isolated from Chinese herb Radix ophiopogonis and shows anti-tumor property. This compound could suppress TGF-β1-mediated metastatic behavior of MDA-MB-231 cells by regulating ITGB1/FAK/Src/AKT/β-catenin/MMP-9 signaling axis. It also attenuates PM2.5-induced inflammation via suppressing the AMPK/NF-κB pathway in mouse pulmonary epithelial cells.
S9106	Eleutheroside E	Eleutheroside E, a principal component of Eleutherococcus senticosus (ES), has anti-inflammatory effects by inhibiting NF-κB and protecting against myocardial infarction.
S3892	Isopsoralen	Isopsoralen (Angelicin), also known as angelicin, is a constituent of roots and leaves of angelica with anti-inflammatory activity and regulates LPS-induced inflammation via inhibiting MAPK/NF-κB pathways. It also shows antiviral activity against gammaherpesviruses.
E0129	Oxysophocarpine	Oxysophocarpine (OSC) is an alkaloid extracted from Sophora alopecuroides. This compound inhibits the growth and metastasis of oral squamous cell carcinoma (OSCC) by targeting the Nrf2/HO-1 axis. It protects cells against apoptosis and inflammatory responses and compromised miR-155 activity by attenuating MAPK and NF-κB pathways.
E0226	Chebulagic acid	Chebulagic acid, isolated form Terminalia chebula Retz, is a reversible and non-competitive inhibitor of maltase with a Ki value of 6.6 μM. This compound shows potent anti-inflammatory effects in LPS-stimulated RAW 264.7 cells. It also shows potent COX–LOX dual inhibition activity with IC50 values of 15 μM, 0.92 μM and 2.1 μM for COX-1, COX-2 and 5-LOX respectively.