Immunology & Inflammation related Modulators

Cat.No.	Product Name	Information	Product Use Citations
S3648	Amlexanox	Amlexanox is an anti-inflammatory antiallergic immunomodulator and also an inhibitor of the protein kinases TBK1 and IKK-ε.	Biomed Pharmacother, 2025, 186:117991 Cell Death Discov, 2025, 11(1):286 Sci Adv, 2025, 11(4):eadq2395
S2787	Laquinimod	Laquinimod (ABR-215062, LAQ) is a potent immunomodulator. Phase 3.	Journal of Neuroinflammation, June 14, 2018, 183 Int Immunopharmacol, 2020, 88:106989 International Immunopharmacology, 2020, 106989
S7516	Y-320	Y-320 is an orally active immunomodulator, and inhibits IL-17 production by CD4 T cells stimulated with IL-15 with IC50 of 20 to 60 nM.	mBio, 2022, e00664-22 mBio, 2022, e0066422 J Virol, 2021, JVI0111921
S7515	VGX-1027	VGX-1027 (GIT 27) is an orally active immunomodulator. Phase 1.	Eur J Pharmacol, 2019, 842:373-383 Chinese Pharmacological Bulletin, 2019, 35(4): 545-550.
S5083	Lentinan	Lentinan (A823605, Bromoduline), isolated and purified from a hot water extract of Lentinula edodes fruit bodies, is a fungal polysaccharide immunomodulator with anti-tumor effects.	Cell Commun Signal, 2024, 22(1):376 Iran J Basic Med Sci, 2023, 26(7):836-842
S3668	Thymopentin	Thymopentin (TP5) has immuno-regulatory activities. The immuno-regulatory actions of thymopentin on peripheral T cells are mediated by intracellular cyclic GMP elevations in contrast to the intracellular cyclic AMP elevations induced in precursor T cells that trigger their further differentiation to T cells.	Frontiers in Oncology, October 19, 2021, 741403 Frontiers in Oncology, 2021, 741403 Front Oncol, 2021, 11:741403
S2307	Roquinimex	Roquinimex (FCF 89, Linomide, LS 2616) is a novel immunomodulator augmenting natural killer (NK) cell activity and T-lymphocyte related effector functions. This compound is a potent oral active tumor antiangiogenic agent. It inhibits the secretion of TNF-α.	iScience, 2024, 27(10):110862
S4842	Balsalazide	Balsalazide (Colazal, Giazo), an aminosalicylate and oral prodrug, is enzymatically cleaved in the colon to produce the anti-inflammatory agent mesalazine. This compound suppresses colitis-associated carcinogenesis through modulation of the IL-6/STAT3 pathway.
E3816	Emilia Sonchifolia Extract	Emilia Sonchifolia Extract is extracted from Emilia sonchifolia, which is a potent immune response modulator.
E3527	Glossy privet fruit Extract	Glossy Privet Fruit Extract is extracted from the fruits of Ligustrum lucidum, which has immunomodulatory effects.
E3821	Alpinia Oxyphyllae Extract	Alpinia Oxyphyllae Extract is extracted from Alpinia oxyphyllae, which has potent activities in modulating multiple signaling pathways associated with β-amyloid deposition, tau protein phosphorylation, chronic inflammation, oxidative stress.
E3540	Grapefruit Extract	Grapefruit Extract is extracted from Citrus paradisi Macf., which can serve as immune modulators in the intestine and maintain intestinal macrophage homeostasis.
E7026	OVA Peptide (323-339)	OVA peptide (323–339) is an immunodominant T‑ and B‑cell epitope of ovalbumin that drives anti‑OVA IgE and immediate hypersensitivity responses in BALB/c mice.
E4972	Efaproxiral	Efaproxiral(RSR13) is a synthetic allosteric modifier of haemoglobin that reduces its oxygen binding affinity, facilitating oxygen release. This increases the whole blood P50 and tissue partial pressure of oxygen (Po2), enhancing oxygen delivery to tissues and improving oxygenation in hypoxic tumors.
E3082	Bupleurum Extract	Bupleurum Extract is extracted from Bupleurum, which has been used in the treatment of inflammation.
E3270	Black Rice Extract	Blackberry Extract is extracted from Rubus fruticosus, which has both anti-inflammatory and pro-inflammatory properties.
E8325^New	Quadrol	Quadrol (N,N,N′,N′-Tetrakis(2-hydroxypropyl)ethylenediamine, EDTP) is an immunostimulant which is considered as a potentially useful active molecule for accelerating wound healing. Quadrol can form a complex with Ca²⁺, mediate the entry of Ca²⁺ into macrophages, and stimulate macrophage activation.
E7006	Taurocholic acid	Taurocholic acid (N-Choloyltaurine), a taurine-conjugated form of cholic acid, is a major bile acid elevated in liver disease. It promotes by activating hepatic stellate cells via TLR4 upregulation and exhibits anti-inflammatory effects in gingival fibroblasts, oral squamous carcinoma cells, and macrophages in vitro.
S1737	Prednisolone	Prednisolone is a synthetic glucocorticoid with anti-inflammatory and immunomodulating properties. This compound is widely used in the treatment of various inflammatory and autoimmune conditions. It works by suppressing the immune response and reducing inflammation in the body. The efficacy of this medication has been well-documented in clinical studies. Patients prescribed this drug should follow their healthcare provider's instructions carefully to minimize potential side effects.	International Journal of Molecular Sciences, November 30, 2019, 6036 eLife, November 19, 2019, e50036 OncoImmunology, March 12, 2026, 2643494
S8301	Ossirene (AS101)	A potent in vitro and in vivo immunomodulator, Ossirene (AS101) is a novel inhibitor of IL-1beta converting enzyme.	International Journal of Oncology, May 21, 2019, 69-80 Journal of Inflammation Research, January 25, 2025, 1191-1205 Mol Neurodegener, 2025, 20(1):5
S8760	Iberdomide (CC-220)	Iberdomide (CC-220) is a novel oral immunomodulatory compound that targets cereblon, part of the CRL4CRBN E3 ubiquitin ligase complex, with an IC50 of 60 nM in a competitive TR-FRET assay. Iberdomide (CC-220) induces apoptosis with antitumor and immunostimulatory activities.	Cell Rep Med, 2025, S2666-3791(25)00102-8 J Med Virol, 2025, 97(8):e70537 Cancer Res, 2025, 10.1158/0008-5472.CAN-24-1136
S7892	Avadomide (CC-122)	Avadomide (CC-122) is a new chemical entity termed pleiotropic pathway modifier and a novel agent for Diffuse large B-cell lymphoma (DLBCL) with antitumor and immunomodulatory activity. Its molecular target is the protein cereblon (CRBN), a substrate receptor of the cullin ring E3 ubiquitin ligase complex CRL4^CRBN.	Molecular Therapy - Oncolytics, June 23, 2020, 215-225 bioRxiv, June 08, 2025, nan Blood Advances, July 23, 2019, 2105-2117
S1733	Methylprednisolone	Methylprednisolone is a synthetic glucocorticoid receptor agonist, used to achieve prompt suppression of inflammation. This compound activates ACE2 and reduces IL-6 levels, thus improves severe or critical COVID-19. It markedly reduces autophagy and apoptosis.	iScience, 2025, 114293 Food Chem Toxicol, 2024, 188:114665 Clinical Cancer Research, 2022, 4444-4455
S5973	Methylprednisolone Acetate	Methylprednisolone (NSC-19987, Medrol) acetate is a synthetic glucocorticoid receptor agonist, used to achieve prompt suppression of inflammation. Methylprednisolone activates ACE2 and reduces IL-6 levels, thus improves severe or critical COVID-19. Methylprednisolone markedly reduces autophagy and apoptosis.	Current Issues in Molecular Biology, 2022, 1046-1061
S5969	Dicloxacillin Sodium hydrate	Dicloxacillin Sodium hydrate (DLX, Dycill, Dynapen, Pathocil), a narrow-spectrum β-Lactam antibiotic of the penicillin class, induces drug-metabolizing CYP enzymes to a clinically relevant extent.