Home Immunology & Inflammation Immunology & Inflammation related

Immunology & Inflammation related Modulators

Cat.No. Product Name Information Product Use Citations Product Validations
S3648 Amlexanox Amlexanox is an anti-inflammatory antiallergic immunomodulator and also an inhibitor of the protein kinases TBK1 and IKK-ε.
Biomed Pharmacother, 2025, 186:117991
Cell Death Discov, 2025, 11(1):286
Sci Adv, 2025, 11(4):eadq2395
S2787 Laquinimod Laquinimod (ABR-215062, LAQ) is a potent immunomodulator. Phase 3.
International Immunopharmacology, 2020, 106989
Int Immunopharmacol, 2020, 88:106989
J Neuroinflammation, 2018, 15(1):183
S7516 Y-320 Y-320 is an orally active immunomodulator, and inhibits IL-17 production by CD4 T cells stimulated with IL-15 with IC50 of 20 to 60 nM.
mBio, 2022, e0066422
J Virol, 2021, JVI0111921
Research Square, 2021, 10.21203/rs.3.rs-742937/v1
S3668 Thymopentin Thymopentin (TP5) has immuno-regulatory activities. The immuno-regulatory actions of thymopentin on peripheral T cells are mediated by intracellular cyclic GMP elevations in contrast to the intracellular cyclic AMP elevations induced in precursor T cells that trigger their further differentiation to T cells.
Frontiers in Oncology, 2021, 741403
Front Oncol, 2021, 11:741403
S5083 Lentinan Lentinan (A823605, Bromoduline), isolated and purified from a hot water extract of Lentinula edodes fruit bodies, is a fungal polysaccharide immunomodulator with anti-tumor effects.
Cell Commun Signal, 2024, 22(1):376
Iran J Basic Med Sci, 2023, 26(7):836-842
S7515 VGX-1027 VGX-1027 (GIT 27) is an orally active immunomodulator. Phase 1.
Eur J Pharmacol, 2019, 842:373-383
S2307 Roquinimex Roquinimex (FCF 89, Linomide, LS 2616) is a novel immunomodulator augmenting natural killer (NK) cell activity and T-lymphocyte related effector functions. This compound is a potent oral active tumor antiangiogenic agent. It inhibits the secretion of TNF-α.
iScience, 2024, 27(10):110862
S4842 Balsalazide Balsalazide (Colazal, Giazo), an aminosalicylate and oral prodrug, is enzymatically cleaved in the colon to produce the anti-inflammatory agent mesalazine. This compound suppresses colitis-associated carcinogenesis through modulation of the IL-6/STAT3 pathway.
E3816 Emilia Sonchifolia Extract Emilia Sonchifolia Extract is extracted from Emilia sonchifolia, which is a potent immune response modulator.
E3527 Glossy privet fruit Extract Glossy Privet Fruit Extract is extracted from the fruits of Ligustrum lucidum, which has immunomodulatory effects.
E3821 Alpinia Oxyphyllae Extract Alpinia Oxyphyllae Extract is extracted from Alpinia oxyphyllae, which has potent activities in modulating multiple signaling pathways associated with β-amyloid deposition, tau protein phosphorylation, chronic inflammation, oxidative stress.
E3540 Grapefruit Extract Grapefruit Extract is extracted from Citrus paradisi Macf., which can serve as immune modulators in the intestine and maintain intestinal macrophage homeostasis.
E4972 Efaproxiral Efaproxiral(RSR13) is a synthetic allosteric modifier of haemoglobin that reduces its oxygen binding affinity, facilitating oxygen release. This increases the whole blood P50 and tissue partial pressure of oxygen (Po2), enhancing oxygen delivery to tissues and improving oxygenation in hypoxic tumors.
E3082 Bupleurum Extract Bupleurum Extract is extracted from Bupleurum, which has been used in the treatment of inflammation.
E3270 Black Rice Extract Blackberry Extract is extracted from Rubus fruticosus, which has both anti-inflammatory and pro-inflammatory properties.
E2723New QS-21 QS-21 (QS-21-Api; Stimulon) is a natural saponin vaccine adjuvant derived from Quillaja saponaria bark that enhances both Th2 humoral and Th1 cell-mediated immune responses by acting on antigen-presenting cells (APCs) and T cells. It activates the NLRP3 inflammasome, leading to caspase-1-dependent release of IL-1β and IL-18 cytokines, which are critical for Th1 immunity and control of intracellular pathogens.
E8325New Quadrol Quadrol (N,N,N′,N′-Tetrakis(2-hydroxypropyl)ethylenediamine, EDTP) is an immunostimulant which is considered as a potentially useful active molecule for accelerating wound healing. Quadrol can form a complex with Ca²⁺, mediate the entry of Ca²⁺ into macrophages, and stimulate macrophage activation.
E7006 Taurocholic acid Taurocholic acid (N-Choloyltaurine), a taurine-conjugated form of cholic acid, is a major bile acid elevated in liver disease. It promotes by activating hepatic stellate cells via TLR4 upregulation and exhibits anti-inflammatory effects in gingival fibroblasts, oral squamous carcinoma cells, and macrophages in vitro.
S1737 Prednisolone Prednisolone is a synthetic glucocorticoid with anti-inflammatory and immunomodulating properties. This compound is widely used in the treatment of various inflammatory and autoimmune conditions. It works by suppressing the immune response and reducing inflammation in the body. The efficacy of this medication has been well-documented in clinical studies. Patients prescribed this drug should follow their healthcare provider's instructions carefully to minimize potential side effects.
Cancers (Basel), 2025, 17(12)2034
Front Oncol, 2025, 15:1520972
Molecules, 2024, 29(7)1546
Verified customer review of Prednisolone
S8760 Iberdomide (CC-220) Iberdomide (CC-220) is a novel oral immunomodulatory compound that targets cereblon, part of the CRL4CRBN E3 ubiquitin ligase complex, with an IC50 of 60 nM in a competitive TR-FRET assay. Iberdomide (CC-220) induces apoptosis with antitumor and immunostimulatory activities.
Cell Rep Med, 2025, S2666-3791(25)00102-8
J Med Virol, 2025, 97(8):e70537
Cancer Res, 2025, 10.1158/0008-5472.CAN-24-1136
S8301 Ossirene (AS101) A potent in vitro and in vivo immunomodulator, Ossirene (AS101) is a novel inhibitor of IL-1beta converting enzyme.
Mol Neurodegener, 2025, 20(1):5
Cell Biosci, 2025, 15(1):18
Stem Cell Rev Rep, 2025, none
S1733 Methylprednisolone Methylprednisolone is a synthetic glucocorticoid receptor agonist, used to achieve prompt suppression of inflammation. This compound activates ACE2 and reduces IL-6 levels, thus improves severe or critical COVID-19. It markedly reduces autophagy and apoptosis.
iScience, 2025, 114293
Food Chem Toxicol, 2024, 188:114665
Clinical Cancer Research, 2022, 4444-4455
Verified customer review of Methylprednisolone
S7892 Avadomide (CC-122) Avadomide (CC-122) is a new chemical entity termed pleiotropic pathway modifier and a novel agent for Diffuse large B-cell lymphoma (DLBCL) with antitumor and immunomodulatory activity. Its molecular target is the protein cereblon (CRBN), a substrate receptor of the cullin ring E3 ubiquitin ligase complex CRL4CRBN.
bioRxiv, 2024, 10.1101/2024.01.28.577572
Cell Chem Biol, 2022, S2451-9456(22)00204-5
Leukemia, 2021, 35(5):1330-1343
S5973 Methylprednisolone Acetate Methylprednisolone (NSC-19987, Medrol) acetate is a synthetic glucocorticoid receptor agonist, used to achieve prompt suppression of inflammation. Methylprednisolone activates ACE2 and reduces IL-6 levels, thus improves severe or critical COVID-19. Methylprednisolone markedly reduces autophagy and apoptosis.
S5969 Dicloxacillin Sodium hydrate Dicloxacillin Sodium hydrate (DLX, Dycill, Dynapen, Pathocil), a narrow-spectrum β-Lactam antibiotic of the penicillin class, induces drug-metabolizing CYP enzymes to a clinically relevant extent.