DNA alkylator Inhibitors

Cat.No.	Product Name	Information	Product Use Citations
S6984	Dianhydrogalactitol (VAL-083)	Dianhydrogalactitol (VAL-083, Dianhydrodulcitol, Dulcitol Diepoxide) is a bi-functional alkylating agent that readily crosses the blood-brain barrier and creates N7 methylation on DNA. It shows antitumor activity.
S4447	Pipobroman	Pipobroman (PB, Vercyte), a neutral amide of piperazine, acts as an alkylating agent with antiproliferative activity.
E4754	Semustine	Semustine is a member of the chloroethyl nitrosourea (CENU) family that induces DNA alkylation at the major groove, forming interstrand cross-links between guanine and cytosine bases (dG-dC). It exerts antitumor activity by inducing these DNA cross-links and is used as an antineoplastic alkylating agent for treating Lewis lung carcinoma, leukemia, and metastatic brain tumors.
S6958	Treosulfan	Treosulfan (NSC 39069, Treosulphan) is an alkylating agent used for conventional and high-dose chemotherapy regimens. This compound is potently cytotoxic against pancreatic cancer cell lines.
E1454^New	Phosphoramide mustard cyclohexanamine	Phosphoramide mustard cyclohexanamine is the stabilized and biologically active cytotoxic metabolite of the prodrug cyclophosphamide that acts as a potent DNA alkylator. It selectively binds the N-7 position of guanine residues to generate cytotoxic mono- and bi-functional DNA adducts. These cross-links physically stall replication forks and trigger the ATM/gammaH2AX DNA damage response pathway, effectively driving malignant cells into apoptosis.
S1312	Streptozotocin (STZ)	Streptozotocin (STZ) is a glucosamine-nitrosourea compound derived from Streptomyces achromogenes, which is a DNA-methylating, carcinogenic, antibiotic and diabetes inducing agent. It induces autophagy and apoptosis. This compound can be used to induce animal models of diabetes. Solutions are unstable and should be fresh-prepared.	Cell Rep Med, 2025, 6(8):102249 J Nanobiotechnology, 2025, 23(1):588 Int J Biol Macromol, 2025, 321(Pt 2):146174
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