DNA alkylator Inhibitors

Cat.No.	Product Name	Information	Product Use Citations
S4447	Pipobroman	Pipobroman (PB, Vercyte), a neutral amide of piperazine, acts as an alkylating agent with antiproliferative activity.
E4754	Semustine	Semustine is a member of the chloroethyl nitrosourea (CENU) family that induces DNA alkylation at the major groove, forming interstrand cross-links between guanine and cytosine bases (dG-dC). It exerts antitumor activity by inducing these DNA cross-links and is used as an antineoplastic alkylating agent for treating Lewis lung carcinoma, leukemia, and metastatic brain tumors.
S6958	Treosulfan	Treosulfan (NSC 39069, Treosulphan) is an alkylating agent used for conventional and high-dose chemotherapy regimens. This compound is potently cytotoxic against pancreatic cancer cell lines.
S5840	Palifosfamide	Palifosfamide (ZIO-201, Isophosphamide mustard) is a novel DNA alkylator and the active metabolite of ifosfamide with potential antineoplastic activity.
S1312	Streptozotocin (STZ)	Streptozotocin (STZ) is a glucosamine-nitrosourea compound derived from Streptomyces achromogenes, which is a DNA-methylating, carcinogenic, antibiotic and diabetes inducing agent. It induces autophagy and apoptosis. This compound can be used to induce animal models of diabetes. Solutions are unstable and should be fresh-prepared.	Cell Rep Med, 2025, 6(8):102249 J Nanobiotechnology, 2025, 23(1):588 Int J Biol Macromol, 2025, 321(Pt 2):146174
S1302	Ifosfamide	Ifosfamide is a nitrogen mustard alkylating agent used in the treatment of cancer. This compound is typically administered intravenously and undergoes metabolic activation in the liver to produce its active alkylating species. The primary mechanism of action of this agent involves cross-linking DNA strands, thereby inhibiting DNA replication and transcription, which leads to cell death. Due to its potential for causing hemorrhagic cystitis, this medication is often used in combination with mesna, a uroprotectant agent. The clinical use of this chemical includes treatment of various cancers, such as germ cell tumors, soft tissue sarcomas, and lymphomas. Despite its efficacy, this drug is associated with several side effects, including myelos	iScience, 2024, 27(10):110862 Cancers (Basel), 2024, 16(21)3565 Cancer Res, 2023, 83(16):2750-2762